-- dump date 20140619_073348 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1045856000001 DnaA N-terminal domain; Region: DnaA_N; pfam11638 1045856000002 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 1045856000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1045856000004 Walker A motif; other site 1045856000005 ATP binding site [chemical binding]; other site 1045856000006 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1045856000007 Walker B motif; other site 1045856000008 arginine finger; other site 1045856000009 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1045856000010 DnaA box-binding interface [nucleotide binding]; other site 1045856000011 DNA polymerase III subunit beta; Validated; Region: PRK05643 1045856000012 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1045856000013 putative DNA binding surface [nucleotide binding]; other site 1045856000014 dimer interface [polypeptide binding]; other site 1045856000015 beta-clamp/clamp loader binding surface; other site 1045856000016 beta-clamp/translesion DNA polymerase binding surface; other site 1045856000017 recF protein; Region: recf; TIGR00611 1045856000018 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1045856000019 Walker A/P-loop; other site 1045856000020 ATP binding site [chemical binding]; other site 1045856000021 Q-loop/lid; other site 1045856000022 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1045856000023 ABC transporter signature motif; other site 1045856000024 Walker B; other site 1045856000025 D-loop; other site 1045856000026 H-loop/switch region; other site 1045856000027 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 1045856000028 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1045856000029 Mg2+ binding site [ion binding]; other site 1045856000030 G-X-G motif; other site 1045856000031 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1045856000032 anchoring element; other site 1045856000033 dimer interface [polypeptide binding]; other site 1045856000034 ATP binding site [chemical binding]; other site 1045856000035 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1045856000036 active site 1045856000037 putative metal-binding site [ion binding]; other site 1045856000038 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1045856000039 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1045856000040 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1045856000041 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_6; cd08475 1045856000042 putative effector binding pocket; other site 1045856000043 putative dimerization interface [polypeptide binding]; other site 1045856000044 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276 1045856000045 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1045856000046 putative NAD(P) binding site [chemical binding]; other site 1045856000047 sugar phosphate phosphatase; Provisional; Region: PRK10513 1045856000048 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1045856000049 active site 1045856000050 motif I; other site 1045856000051 motif II; other site 1045856000052 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1045856000053 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1045856000054 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1045856000055 DNA-binding site [nucleotide binding]; DNA binding site 1045856000056 FCD domain; Region: FCD; pfam07729 1045856000057 2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734 1045856000058 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 1045856000059 2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140 1045856000060 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 1045856000061 active site 1045856000062 intersubunit interface [polypeptide binding]; other site 1045856000063 catalytic residue [active] 1045856000064 galactonate dehydratase; Provisional; Region: PRK14017 1045856000065 D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325 1045856000066 putative active site pocket [active] 1045856000067 putative metal binding site [ion binding]; other site 1045856000068 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1045856000069 D-galactonate transporter; Region: 2A0114; TIGR00893 1045856000070 putative substrate translocation pore; other site 1045856000071 Protein of unknown function (DUF3748); Region: DUF3748; pfam12566 1045856000072 hypothetical protein; Provisional; Region: PRK11616 1045856000073 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1045856000074 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 1045856000075 putative dimer interface [polypeptide binding]; other site 1045856000076 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1045856000077 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 1045856000078 putative dimer interface [polypeptide binding]; other site 1045856000079 putative transporter; Validated; Region: PRK03818 1045856000080 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 1045856000081 TrkA-C domain; Region: TrkA_C; pfam02080 1045856000082 TrkA-C domain; Region: TrkA_C; pfam02080 1045856000083 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 1045856000084 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1045856000085 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1045856000086 DNA-binding site [nucleotide binding]; DNA binding site 1045856000087 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 1045856000088 PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005 1045856000089 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 1045856000090 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1045856000091 active site turn [active] 1045856000092 phosphorylation site [posttranslational modification] 1045856000093 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 1045856000094 Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298 1045856000095 NAD binding site [chemical binding]; other site 1045856000096 sugar binding site [chemical binding]; other site 1045856000097 divalent metal binding site [ion binding]; other site 1045856000098 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 1045856000099 dimer interface [polypeptide binding]; other site 1045856000100 Predicted membrane protein [Function unknown]; Region: COG2149 1045856000101 Domain of unknown function (DUF202); Region: DUF202; pfam02656 1045856000102 D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine to pyruvate and ammonia. D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447 1045856000103 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 1045856000104 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1045856000105 catalytic residue [active] 1045856000106 permease DsdX; Provisional; Region: PRK09921 1045856000107 gluconate transporter; Region: gntP; TIGR00791 1045856000108 DNA-binding transcriptional regulator DsdC; Provisional; Region: PRK10086 1045856000109 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1045856000110 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 1045856000111 dimerization interface [polypeptide binding]; other site 1045856000112 substrate binding pocket [chemical binding]; other site 1045856000113 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 1045856000114 multidrug resistance protein D; Provisional; Region: emrD; PRK11652 1045856000115 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1045856000116 putative substrate translocation pore; other site 1045856000117 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 1045856000118 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1045856000119 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1045856000120 Coenzyme A binding pocket [chemical binding]; other site 1045856000121 acetolactate synthase catalytic subunit; Validated; Region: PRK08155 1045856000122 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1045856000123 PYR/PP interface [polypeptide binding]; other site 1045856000124 dimer interface [polypeptide binding]; other site 1045856000125 TPP binding site [chemical binding]; other site 1045856000126 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1045856000127 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1045856000128 TPP-binding site [chemical binding]; other site 1045856000129 dimer interface [polypeptide binding]; other site 1045856000130 Acetolactate synthase, small (regulatory) subunit [Amino acid transport and metabolism]; Region: IlvH; COG0440 1045856000131 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 1045856000132 putative valine binding site [chemical binding]; other site 1045856000133 dimer interface [polypeptide binding]; other site 1045856000134 DNA-binding transcriptional activator UhpA; Provisional; Region: PRK10360 1045856000135 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1045856000136 active site 1045856000137 phosphorylation site [posttranslational modification] 1045856000138 intermolecular recognition site; other site 1045856000139 dimerization interface [polypeptide binding]; other site 1045856000140 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1045856000141 DNA binding residues [nucleotide binding] 1045856000142 dimerization interface [polypeptide binding]; other site 1045856000143 sensory histidine kinase UhpB; Provisional; Region: PRK11644 1045856000144 MASE1; Region: MASE1; pfam05231 1045856000145 Histidine kinase; Region: HisKA_3; pfam07730 1045856000146 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1045856000147 ATP binding site [chemical binding]; other site 1045856000148 Mg2+ binding site [ion binding]; other site 1045856000149 G-X-G motif; other site 1045856000150 regulatory protein UhpC; Provisional; Region: PRK11663 1045856000151 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1045856000152 putative substrate translocation pore; other site 1045856000153 sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556 1045856000154 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1045856000155 putative substrate translocation pore; other site 1045856000156 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1045856000157 Alpha/beta hydrolase of unknown function (DUF1057); Region: DUF1057; pfam06342 1045856000158 Protein of unknown function (DUF1198); Region: DUF1198; pfam06711 1045856000159 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1045856000160 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1045856000161 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1045856000162 dimerization interface [polypeptide binding]; other site 1045856000163 substrate binding pocket [chemical binding]; other site 1045856000164 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1045856000165 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1045856000166 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1045856000167 putative substrate translocation pore; other site 1045856000168 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 1045856000169 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 1045856000170 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 1045856000171 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1045856000172 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1045856000173 active site 1045856000174 catalytic tetrad [active] 1045856000175 ribonucleoside transporter; Reviewed; Region: nepI; PRK10213 1045856000176 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1045856000177 putative substrate translocation pore; other site 1045856000178 EamA-like transporter family; Region: EamA; pfam00892 1045856000179 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1045856000180 EamA-like transporter family; Region: EamA; pfam00892 1045856000181 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1045856000182 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 1045856000183 methionine cluster; other site 1045856000184 active site 1045856000185 phosphorylation site [posttranslational modification] 1045856000186 metal binding site [ion binding]; metal-binding site 1045856000187 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 1045856000188 beta-galactosidase; Region: BGL; TIGR03356 1045856000189 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1045856000190 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 1045856000191 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 1045856000192 active site 1045856000193 P-loop; other site 1045856000194 phosphorylation site [posttranslational modification] 1045856000195 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1045856000196 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1045856000197 DNA binding site [nucleotide binding] 1045856000198 domain linker motif; other site 1045856000199 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1045856000200 ligand binding site [chemical binding]; other site 1045856000201 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 1045856000202 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 1045856000203 Protein export membrane protein; Region: SecD_SecF; cl14618 1045856000204 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 1045856000205 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1045856000206 HlyD family secretion protein; Region: HlyD_3; pfam13437 1045856000207 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1045856000208 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1045856000209 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1045856000210 Coenzyme A binding pocket [chemical binding]; other site 1045856000211 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1045856000212 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1045856000213 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1045856000214 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1045856000215 putative substrate translocation pore; other site 1045856000216 cytoplasmic membrane lipoprotein-28; Provisional; Region: PRK09861 1045856000217 lipoprotein, YaeC family; Region: TIGR00363 1045856000218 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 1045856000219 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1045856000220 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1045856000221 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1045856000222 putative substrate translocation pore; other site 1045856000223 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1045856000224 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1045856000225 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 1045856000226 putative effector binding pocket; other site 1045856000227 putative dimerization interface [polypeptide binding]; other site 1045856000228 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1045856000229 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 1045856000230 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 1045856000231 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 1045856000232 conserved cys residue [active] 1045856000233 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1045856000234 Predicted ATPase [General function prediction only]; Region: COG4637 1045856000235 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1045856000236 Walker A/P-loop; other site 1045856000237 ATP binding site [chemical binding]; other site 1045856000238 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1045856000239 ABC transporter signature motif; other site 1045856000240 Walker B; other site 1045856000241 D-loop; other site 1045856000242 H-loop/switch region; other site 1045856000243 Protein of unknown function (DUF523); Region: DUF523; pfam04463 1045856000244 Uncharacterized conserved protein [Function unknown]; Region: COG3272 1045856000245 Protein of unknown function (DUF1722); Region: DUF1722; cl01284 1045856000246 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 1045856000247 active site 1045856000248 homotetramer interface [polypeptide binding]; other site 1045856000249 transcriptional regulator MirA; Provisional; Region: PRK15043 1045856000250 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 1045856000251 DNA binding residues [nucleotide binding] 1045856000252 outer membrane lipoprotein Blc; Provisional; Region: PRK10477 1045856000253 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 1045856000254 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1045856000255 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1045856000256 Coenzyme A binding pocket [chemical binding]; other site 1045856000257 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 1045856000258 putative transporter; Provisional; Region: PRK11462 1045856000259 putative alpha-glucosidase; Provisional; Region: PRK10658 1045856000260 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 1045856000261 YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593 1045856000262 active site 1045856000263 homotrimer interface [polypeptide binding]; other site 1045856000264 catalytic site [active] 1045856000265 homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site 1045856000266 AsmA family; Region: AsmA; pfam05170 1045856000267 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 1045856000268 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 1045856000269 sodium--glutamate symport carrier (gltS); Region: gltS; TIGR00210 1045856000270 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 1045856000271 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1045856000272 generic binding surface II; other site 1045856000273 ssDNA binding site; other site 1045856000274 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1045856000275 ATP binding site [chemical binding]; other site 1045856000276 putative Mg++ binding site [ion binding]; other site 1045856000277 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1045856000278 nucleotide binding region [chemical binding]; other site 1045856000279 ATP-binding site [chemical binding]; other site 1045856000280 tRNA guanosine-2'-O-methyltransferase; Provisional; Region: PRK11081 1045856000281 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1045856000282 SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105 1045856000283 bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092 1045856000284 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1045856000285 Zn2+ binding site [ion binding]; other site 1045856000286 Mg2+ binding site [ion binding]; other site 1045856000287 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1045856000288 synthetase active site [active] 1045856000289 NTP binding site [chemical binding]; other site 1045856000290 metal binding site [ion binding]; metal-binding site 1045856000291 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1045856000292 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1045856000293 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 1045856000294 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1045856000295 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1045856000296 catalytic site [active] 1045856000297 G-X2-G-X-G-K; other site 1045856000298 NAD-dependent DNA ligase LigB; Reviewed; Region: ligB; PRK08097 1045856000299 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295 1045856000300 nucleotide binding pocket [chemical binding]; other site 1045856000301 K-X-D-G motif; other site 1045856000302 catalytic site [active] 1045856000303 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1045856000304 Predicted membrane protein [Function unknown]; Region: COG2860 1045856000305 UPF0126 domain; Region: UPF0126; pfam03458 1045856000306 UPF0126 domain; Region: UPF0126; pfam03458 1045856000307 hypothetical protein; Provisional; Region: PRK11820 1045856000308 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 1045856000309 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 1045856000310 ribonuclease PH; Reviewed; Region: rph; PRK00173 1045856000311 Ribonuclease PH; Region: RNase_PH_bact; cd11362 1045856000312 hexamer interface [polypeptide binding]; other site 1045856000313 active site 1045856000314 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1045856000315 active site 1045856000316 division inhibitor protein; Provisional; Region: slmA; PRK09480 1045856000317 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1045856000318 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1045856000319 trimer interface [polypeptide binding]; other site 1045856000320 active site 1045856000321 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 1045856000322 Flavoprotein; Region: Flavoprotein; pfam02441 1045856000323 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 1045856000324 hypothetical protein; Reviewed; Region: PRK00024 1045856000325 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 1045856000326 MPN+ (JAMM) motif; other site 1045856000327 Zinc-binding site [ion binding]; other site 1045856000328 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1045856000329 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 1045856000330 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 1045856000331 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 1045856000332 DNA binding site [nucleotide binding] 1045856000333 catalytic residue [active] 1045856000334 H2TH interface [polypeptide binding]; other site 1045856000335 putative catalytic residues [active] 1045856000336 turnover-facilitating residue; other site 1045856000337 intercalation triad [nucleotide binding]; other site 1045856000338 8OG recognition residue [nucleotide binding]; other site 1045856000339 putative reading head residues; other site 1045856000340 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1045856000341 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1045856000342 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1045856000343 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1045856000344 active site 1045856000345 (T/H)XGH motif; other site 1045856000346 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1045856000347 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 1045856000348 putative metal binding site; other site 1045856000349 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 1045856000350 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 1045856000351 Glycosyl transferases group 1; Region: Glycos_transf_1; pfam00534 1045856000352 putative glycosyl transferase; Provisional; Region: PRK10073 1045856000353 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1045856000354 active site 1045856000355 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1045856000356 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 1045856000357 putative ADP-binding pocket [chemical binding]; other site 1045856000358 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1045856000359 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1045856000360 lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK10422 1045856000361 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1045856000362 putative active site [active] 1045856000363 Putative catalytic domain of lipopolysaccharide biosynthesis protein WalW and its bacterial homologs; Region: CE4_WalW; cd10935 1045856000364 putative active site [active] 1045856000365 putative catalytic site [active] 1045856000366 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 1045856000367 O-Antigen ligase; Region: Wzy_C; pfam04932 1045856000368 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1045856000369 active site 1045856000370 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1045856000371 Glycosyltransferase family 9 (heptosyltransferase); Region: Glyco_transf_9; pfam01075 1045856000372 putative active site [active] 1045856000373 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1045856000374 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1045856000375 putative active site [active] 1045856000376 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1045856000377 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1045856000378 putative active site [active] 1045856000379 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 1045856000380 ADP-L-glycero-D-mannoheptose-6-epimerase; Provisional; Region: rfaD; PRK11150 1045856000381 NADP binding site [chemical binding]; other site 1045856000382 homopentamer interface [polypeptide binding]; other site 1045856000383 substrate binding site [chemical binding]; other site 1045856000384 active site 1045856000385 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1045856000386 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 1045856000387 substrate-cofactor binding pocket; other site 1045856000388 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1045856000389 catalytic residue [active] 1045856000390 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 1045856000391 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1045856000392 NAD(P) binding site [chemical binding]; other site 1045856000393 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1045856000394 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 1045856000395 putative ADP-binding pocket [chemical binding]; other site 1045856000396 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 1045856000397 NodB motif; other site 1045856000398 putative active site [active] 1045856000399 putative catalytic site [active] 1045856000400 Zn binding site [ion binding]; other site 1045856000401 AmiB activator; Provisional; Region: PRK11637 1045856000402 Peptidase family M23; Region: Peptidase_M23; pfam01551 1045856000403 phosphoglyceromutase; Provisional; Region: PRK05434 1045856000404 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: pgm_bpd_ind; TIGR01307 1045856000405 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1045856000406 active site residue [active] 1045856000407 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 1045856000408 GSH binding site [chemical binding]; other site 1045856000409 catalytic residues [active] 1045856000410 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557 1045856000411 SecA binding site; other site 1045856000412 Preprotein binding site; other site 1045856000413 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 1045856000414 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1045856000415 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1045856000416 serine acetyltransferase; Provisional; Region: cysE; PRK11132 1045856000417 Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426 1045856000418 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1045856000419 trimer interface [polypeptide binding]; other site 1045856000420 active site 1045856000421 substrate binding site [chemical binding]; other site 1045856000422 CoA binding site [chemical binding]; other site 1045856000423 putative rRNA methylase; Provisional; Region: PRK10358 1045856000424 benzoate transport; Region: 2A0115; TIGR00895 1045856000425 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1045856000426 putative substrate translocation pore; other site 1045856000427 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1045856000428 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 1045856000429 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 1045856000430 active site 1045856000431 substrate binding site [chemical binding]; other site 1045856000432 FMN binding site [chemical binding]; other site 1045856000433 putative catalytic residues [active] 1045856000434 DNA-binding transcriptional repressor LldR; Provisional; Region: PRK10421 1045856000435 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1045856000436 DNA-binding site [nucleotide binding]; DNA binding site 1045856000437 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1045856000438 L-lactate permease; Provisional; Region: PRK10420 1045856000439 glycolate transporter; Provisional; Region: PRK09695 1045856000440 hypothetical protein; Provisional; Region: PRK11020 1045856000441 Transcriptional regulator [Transcription]; Region: MtlR; COG3722 1045856000442 mannitol repressor protein; Provisional; Region: mtlR; PRK11001 1045856000443 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 1045856000444 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1045856000445 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1045856000446 PTS system mannitol-specific transporter subunit IICBA; Provisional; Region: PRK15083 1045856000447 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 1045856000448 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 1045856000449 active site 1045856000450 P-loop; other site 1045856000451 phosphorylation site [posttranslational modification] 1045856000452 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1045856000453 active site 1045856000454 phosphorylation site [posttranslational modification] 1045856000455 Protein of unknown function (DUF3302); Region: DUF3302; pfam11742 1045856000456 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 1045856000457 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1045856000458 HlyD family secretion protein; Region: HlyD_3; pfam13437 1045856000459 putative glutathione S-transferase; Provisional; Region: PRK10357 1045856000460 GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049 1045856000461 putative C-terminal domain interface [polypeptide binding]; other site 1045856000462 putative GSH binding site (G-site) [chemical binding]; other site 1045856000463 putative dimer interface [polypeptide binding]; other site 1045856000464 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 1045856000465 dimer interface [polypeptide binding]; other site 1045856000466 N-terminal domain interface [polypeptide binding]; other site 1045856000467 putative substrate binding pocket (H-site) [chemical binding]; other site 1045856000468 selenocysteine synthase; Provisional; Region: PRK04311 1045856000469 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390 1045856000470 Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921 1045856000471 selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512 1045856000472 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 1045856000473 G1 box; other site 1045856000474 putative GEF interaction site [polypeptide binding]; other site 1045856000475 GTP/Mg2+ binding site [chemical binding]; other site 1045856000476 Switch I region; other site 1045856000477 G2 box; other site 1045856000478 G3 box; other site 1045856000479 Switch II region; other site 1045856000480 G4 box; other site 1045856000481 G5 box; other site 1045856000482 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 1045856000483 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094 1045856000484 Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106 1045856000485 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 1045856000486 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 1045856000487 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1045856000488 NAD(P) binding site [chemical binding]; other site 1045856000489 catalytic residues [active] 1045856000490 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1045856000491 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1045856000492 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1045856000493 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 1045856000494 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 1045856000495 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 1045856000496 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 1045856000497 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 1045856000498 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1045856000499 Helix-turn-helix domain; Region: HTH_18; pfam12833 1045856000500 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1045856000501 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 1045856000502 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 1045856000503 intersubunit interface [polypeptide binding]; other site 1045856000504 active site 1045856000505 Zn2+ binding site [ion binding]; other site 1045856000506 putative L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13210 1045856000507 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 1045856000508 AP (apurinic/apyrimidinic) site pocket; other site 1045856000509 DNA interaction; other site 1045856000510 Metal-binding active site; metal-binding site 1045856000511 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 1045856000512 active site 1045856000513 dimer interface [polypeptide binding]; other site 1045856000514 magnesium binding site [ion binding]; other site 1045856000515 L-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802 1045856000516 putative N- and C-terminal domain interface [polypeptide binding]; other site 1045856000517 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 1045856000518 putative active site [active] 1045856000519 MgATP binding site [chemical binding]; other site 1045856000520 catalytic site [active] 1045856000521 metal binding site [ion binding]; metal-binding site 1045856000522 putative xylulose binding site [chemical binding]; other site 1045856000523 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1045856000524 D-galactonate transporter; Region: 2A0114; TIGR00893 1045856000525 putative substrate translocation pore; other site 1045856000526 Domain of unknown function (DUF386); Region: DUF386; pfam04074 1045856000527 2,3-diketo-L-gulonate reductase; Provisional; Region: PRK13260 1045856000528 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1045856000529 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1045856000530 Bacterial transcriptional regulator; Region: IclR; pfam01614 1045856000531 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 1045856000532 valine--pyruvate transaminase; Provisional; Region: avtA; PRK09440 1045856000533 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1045856000534 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1045856000535 homodimer interface [polypeptide binding]; other site 1045856000536 catalytic residue [active] 1045856000537 alpha-amylase; Reviewed; Region: malS; PRK09505 1045856000538 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 1045856000539 active site 1045856000540 catalytic site [active] 1045856000541 hypothetical protein; Provisional; Region: PRK10356 1045856000542 Uncharacterized FlgJ-related protein [General function prediction only]; Region: Bax; COG2992 1045856000543 Ligand-binding domain of DNA transcription repressor specific for xylose (XylR); Region: PBP1_XylR; cd01543 1045856000544 putative dimerization interface [polypeptide binding]; other site 1045856000545 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1045856000546 putative ligand binding site [chemical binding]; other site 1045856000547 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1045856000548 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1045856000549 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1045856000550 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1045856000551 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1045856000552 TM-ABC transporter signature motif; other site 1045856000553 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 1045856000554 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1045856000555 Walker A/P-loop; other site 1045856000556 ATP binding site [chemical binding]; other site 1045856000557 Q-loop/lid; other site 1045856000558 ABC transporter signature motif; other site 1045856000559 Walker B; other site 1045856000560 D-loop; other site 1045856000561 H-loop/switch region; other site 1045856000562 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1045856000563 D-xylose transporter subunit XylF; Provisional; Region: xylF; PRK10355 1045856000564 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 1045856000565 putative ligand binding site [chemical binding]; other site 1045856000566 xylose isomerase; Provisional; Region: PRK05474 1045856000567 xylose isomerase; Region: xylose_isom_A; TIGR02630 1045856000568 xylulokinase; Provisional; Region: PRK15027 1045856000569 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 1045856000570 N- and C-terminal domain interface [polypeptide binding]; other site 1045856000571 active site 1045856000572 MgATP binding site [chemical binding]; other site 1045856000573 catalytic site [active] 1045856000574 metal binding site [ion binding]; metal-binding site 1045856000575 xylulose binding site [chemical binding]; other site 1045856000576 homodimer interface [polypeptide binding]; other site 1045856000577 Isochorismatase family; Region: Isochorismatase; pfam00857 1045856000578 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 1045856000579 catalytic triad [active] 1045856000580 conserved cis-peptide bond; other site 1045856000581 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1045856000582 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 1045856000583 conserved cys residue [active] 1045856000584 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1045856000585 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 1045856000586 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1045856000587 Protein of unknown function (DUF1471); Region: DUF1471; cl11507 1045856000588 YsaB-like lipoprotein; Region: YsaB; pfam13983 1045856000589 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 1045856000590 dimer interface [polypeptide binding]; other site 1045856000591 motif 1; other site 1045856000592 active site 1045856000593 motif 2; other site 1045856000594 motif 3; other site 1045856000595 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 1045856000596 DALR anticodon binding domain; Region: DALR_1; pfam05746 1045856000597 anticodon binding site; other site 1045856000598 tRNA binding surface [nucleotide binding]; other site 1045856000599 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1045856000600 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1045856000601 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1045856000602 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1045856000603 salt bridge; other site 1045856000604 non-specific DNA binding site [nucleotide binding]; other site 1045856000605 sequence-specific DNA binding site [nucleotide binding]; other site 1045856000606 Protein of unknown function (DUF3053); Region: DUF3053; pfam11254 1045856000607 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1045856000608 DNA-binding site [nucleotide binding]; DNA binding site 1045856000609 RNA-binding motif; other site 1045856000610 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 1045856000611 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 1045856000612 dimerization interface [polypeptide binding]; other site 1045856000613 ligand binding site [chemical binding]; other site 1045856000614 NADP binding site [chemical binding]; other site 1045856000615 catalytic site [active] 1045856000616 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1045856000617 D-galactonate transporter; Region: 2A0114; TIGR00893 1045856000618 putative substrate translocation pore; other site 1045856000619 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1045856000620 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1045856000621 substrate binding site [chemical binding]; other site 1045856000622 ATP binding site [chemical binding]; other site 1045856000623 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1045856000624 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1045856000625 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1045856000626 DNA binding site [nucleotide binding] 1045856000627 domain linker motif; other site 1045856000628 Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283 1045856000629 putative dimerization interface [polypeptide binding]; other site 1045856000630 putative ligand binding site [chemical binding]; other site 1045856000631 putative outer membrane lipoprotein; Provisional; Region: PRK10510 1045856000632 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1045856000633 ligand binding site [chemical binding]; other site 1045856000634 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 1045856000635 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 1045856000636 molybdopterin cofactor binding site [chemical binding]; other site 1045856000637 substrate binding site [chemical binding]; other site 1045856000638 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 1045856000639 molybdopterin cofactor binding site; other site 1045856000640 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1045856000641 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1045856000642 Coenzyme A binding pocket [chemical binding]; other site 1045856000643 3-methyl-adenine DNA glycosylase I; Provisional; Region: PRK10353 1045856000644 Autotransporter beta-domain; Region: Autotransporter; cl17461 1045856000645 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 1045856000646 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1045856000647 putative substrate translocation pore; other site 1045856000648 phosphoethanolamine transferase; Provisional; Region: PRK11560 1045856000649 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 1045856000650 Sulfatase; Region: Sulfatase; pfam00884 1045856000651 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1045856000652 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 1045856000653 peptide binding site [polypeptide binding]; other site 1045856000654 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1045856000655 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1045856000656 dimer interface [polypeptide binding]; other site 1045856000657 conserved gate region; other site 1045856000658 putative PBP binding loops; other site 1045856000659 ABC-ATPase subunit interface; other site 1045856000660 dipeptide transporter; Provisional; Region: PRK10913 1045856000661 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1045856000662 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1045856000663 putative PBP binding loops; other site 1045856000664 dimer interface [polypeptide binding]; other site 1045856000665 ABC-ATPase subunit interface; other site 1045856000666 dipeptide transporter ATP-binding subunit; Provisional; Region: dppD; PRK11022 1045856000667 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1045856000668 Walker A/P-loop; other site 1045856000669 ATP binding site [chemical binding]; other site 1045856000670 Q-loop/lid; other site 1045856000671 ABC transporter signature motif; other site 1045856000672 Walker B; other site 1045856000673 D-loop; other site 1045856000674 H-loop/switch region; other site 1045856000675 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1045856000676 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 1045856000677 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1045856000678 Walker A/P-loop; other site 1045856000679 ATP binding site [chemical binding]; other site 1045856000680 Q-loop/lid; other site 1045856000681 ABC transporter signature motif; other site 1045856000682 Walker B; other site 1045856000683 D-loop; other site 1045856000684 H-loop/switch region; other site 1045856000685 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1045856000686 pantothenate kinase; Provisional; Region: PRK05439 1045856000687 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 1045856000688 ATP-binding site [chemical binding]; other site 1045856000689 CoA-binding site [chemical binding]; other site 1045856000690 Mg2+-binding site [ion binding]; other site 1045856000691 elongation factor Tu; Reviewed; Region: PRK00049 1045856000692 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1045856000693 G1 box; other site 1045856000694 GEF interaction site [polypeptide binding]; other site 1045856000695 GTP/Mg2+ binding site [chemical binding]; other site 1045856000696 Switch I region; other site 1045856000697 G2 box; other site 1045856000698 G3 box; other site 1045856000699 Switch II region; other site 1045856000700 G4 box; other site 1045856000701 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1045856000702 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1045856000703 Antibiotic Binding Site [chemical binding]; other site 1045856000704 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 1045856000705 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1045856000706 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1045856000707 putative homodimer interface [polypeptide binding]; other site 1045856000708 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1045856000709 heterodimer interface [polypeptide binding]; other site 1045856000710 homodimer interface [polypeptide binding]; other site 1045856000711 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1045856000712 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1045856000713 23S rRNA interface [nucleotide binding]; other site 1045856000714 L7/L12 interface [polypeptide binding]; other site 1045856000715 putative thiostrepton binding site; other site 1045856000716 L25 interface [polypeptide binding]; other site 1045856000717 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1045856000718 mRNA/rRNA interface [nucleotide binding]; other site 1045856000719 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1045856000720 23S rRNA interface [nucleotide binding]; other site 1045856000721 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1045856000722 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1045856000723 core dimer interface [polypeptide binding]; other site 1045856000724 peripheral dimer interface [polypeptide binding]; other site 1045856000725 L10 interface [polypeptide binding]; other site 1045856000726 L11 interface [polypeptide binding]; other site 1045856000727 putative EF-Tu interaction site [polypeptide binding]; other site 1045856000728 putative EF-G interaction site [polypeptide binding]; other site 1045856000729 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 1045856000730 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1045856000731 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 1045856000732 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1045856000733 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 1045856000734 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1045856000735 RPB3 interaction site [polypeptide binding]; other site 1045856000736 RPB1 interaction site [polypeptide binding]; other site 1045856000737 RPB11 interaction site [polypeptide binding]; other site 1045856000738 RPB10 interaction site [polypeptide binding]; other site 1045856000739 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1045856000740 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 1045856000741 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 1045856000742 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1045856000743 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1045856000744 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 1045856000745 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 1045856000746 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 1045856000747 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 1045856000748 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1045856000749 DNA binding site [nucleotide binding] 1045856000750 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1045856000751 methionine cluster; other site 1045856000752 PTS system, Lactose/Cellobiose specific IIA subunit; Region: PTS_IIA; pfam02255 1045856000753 active site 1045856000754 phosphorylation site [posttranslational modification] 1045856000755 metal binding site [ion binding]; metal-binding site 1045856000756 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 1045856000757 active site 1045856000758 P-loop; other site 1045856000759 phosphorylation site [posttranslational modification] 1045856000760 Cache domain; Region: Cache_1; pfam02743 1045856000761 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1045856000762 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1045856000763 metal binding site [ion binding]; metal-binding site 1045856000764 active site 1045856000765 I-site; other site 1045856000766 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240 1045856000767 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1045856000768 FeS/SAM binding site; other site 1045856000769 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 1045856000770 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 1045856000771 ThiS interaction site; other site 1045856000772 putative active site [active] 1045856000773 tetramer interface [polypeptide binding]; other site 1045856000774 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 1045856000775 thiS-thiF/thiG interaction site; other site 1045856000776 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1045856000777 thiazole biosynthesis adenylyltransferase ThiF, E. coli subfamily; Region: adenyl_thiF; TIGR02356 1045856000778 ATP binding site [chemical binding]; other site 1045856000779 substrate interface [chemical binding]; other site 1045856000780 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1045856000781 thiamine phosphate binding site [chemical binding]; other site 1045856000782 active site 1045856000783 pyrophosphate binding site [ion binding]; other site 1045856000784 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 1045856000785 ThiC-associated domain; Region: ThiC-associated; pfam13667 1045856000786 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 1045856000787 anti-RNA polymerase sigma 70 factor; Provisional; Region: PRK11718 1045856000788 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 1045856000789 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 1045856000790 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 1045856000791 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 1045856000792 putative NADH binding site [chemical binding]; other site 1045856000793 putative active site [active] 1045856000794 nudix motif; other site 1045856000795 putative metal binding site [ion binding]; other site 1045856000796 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 1045856000797 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 1045856000798 substrate binding site [chemical binding]; other site 1045856000799 active site 1045856000800 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 1045856000801 Active_site [active] 1045856000802 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3068 1045856000803 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1045856000804 IHF dimer interface [polypeptide binding]; other site 1045856000805 IHF - DNA interface [nucleotide binding]; other site 1045856000806 Protein of unknown function (DUF1481); Region: DUF1481; pfam07356 1045856000807 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 1045856000808 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1045856000809 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 1045856000810 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 1045856000811 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 1045856000812 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1045856000813 purine monophosphate binding site [chemical binding]; other site 1045856000814 dimer interface [polypeptide binding]; other site 1045856000815 putative catalytic residues [active] 1045856000816 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 1045856000817 homoserine O-succinyltransferase; Provisional; Region: PRK05368 1045856000818 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 1045856000819 proposed active site lysine [active] 1045856000820 conserved cys residue [active] 1045856000821 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 1045856000822 malate synthase A; Region: malate_syn_A; TIGR01344 1045856000823 active site 1045856000824 isocitrate lyase; Provisional; Region: PRK15063 1045856000825 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1045856000826 tetramer interface [polypeptide binding]; other site 1045856000827 active site 1045856000828 Mg2+/Mn2+ binding site [ion binding]; other site 1045856000829 bifunctional isocitrate dehydrogenase kinase/phosphatase protein; Validated; Region: aceK; PRK02946 1045856000830 Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579 1045856000831 transcriptional repressor IclR; Provisional; Region: PRK11569 1045856000832 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1045856000833 Bacterial transcriptional regulator; Region: IclR; pfam01614 1045856000834 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 1045856000835 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 1045856000836 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 1045856000837 substrate binding pocket [chemical binding]; other site 1045856000838 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 1045856000839 B12 binding site [chemical binding]; other site 1045856000840 cobalt ligand [ion binding]; other site 1045856000841 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 1045856000842 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 1045856000843 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 1045856000844 23S rRNA pseudouridine synthase F; Provisional; Region: PRK10475 1045856000845 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1045856000846 RNA binding surface [nucleotide binding]; other site 1045856000847 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 1045856000848 probable active site [active] 1045856000849 hypothetical protein; Provisional; Region: PRK10515 1045856000850 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 1045856000851 Sodium Bile acid symporter family; Region: SBF; cl17470 1045856000852 aspartate kinase III; Validated; Region: PRK09084 1045856000853 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 1045856000854 nucleotide binding site [chemical binding]; other site 1045856000855 substrate binding site [chemical binding]; other site 1045856000856 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1045856000857 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_2; cd04917 1045856000858 dimer interface [polypeptide binding]; other site 1045856000859 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 1045856000860 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1045856000861 active site 1045856000862 dimer interface [polypeptide binding]; other site 1045856000863 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1045856000864 dimer interface [polypeptide binding]; other site 1045856000865 active site 1045856000866 Protein of unknown function (DUF2886); Region: DUF2886; pfam11102 1045856000867 Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251 1045856000868 Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082 1045856000869 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 1045856000870 putative trimer interface [polypeptide binding]; other site 1045856000871 putative active site [active] 1045856000872 putative substrate binding site [chemical binding]; other site 1045856000873 putative CoA binding site [chemical binding]; other site 1045856000874 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1045856000875 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1045856000876 Coenzyme A binding pocket [chemical binding]; other site 1045856000877 phosphate-starvation-inducible protein PsiE; Provisional; Region: PRK02833 1045856000878 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1045856000879 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1045856000880 dimer interface [polypeptide binding]; other site 1045856000881 conserved gate region; other site 1045856000882 putative PBP binding loops; other site 1045856000883 ABC-ATPase subunit interface; other site 1045856000884 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1045856000885 dimer interface [polypeptide binding]; other site 1045856000886 conserved gate region; other site 1045856000887 putative PBP binding loops; other site 1045856000888 ABC-ATPase subunit interface; other site 1045856000889 maltose ABC transporter periplasmic protein; Reviewed; Region: malE; PRK09474 1045856000890 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1045856000891 maltose/maltodextrin transporter ATP-binding protein; Provisional; Region: PRK11000 1045856000892 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1045856000893 Walker A/P-loop; other site 1045856000894 ATP binding site [chemical binding]; other site 1045856000895 Q-loop/lid; other site 1045856000896 ABC transporter signature motif; other site 1045856000897 Walker B; other site 1045856000898 D-loop; other site 1045856000899 H-loop/switch region; other site 1045856000900 TOBE domain; Region: TOBE_2; pfam08402 1045856000901 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 1045856000902 trimer interface; other site 1045856000903 sugar binding site [chemical binding]; other site 1045856000904 maltose regulon periplasmic protein; Provisional; Region: PRK10564 1045856000905 chorismate pyruvate lyase; Provisional; Region: ubiC; PRK11655 1045856000906 4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848 1045856000907 UbiA prenyltransferase family; Region: UbiA; pfam01040 1045856000908 glycerol-3-phosphate O-acyltransferase; Region: plsB; TIGR03703 1045856000909 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 1045856000910 putative acyl-acceptor binding pocket; other site 1045856000911 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 1045856000912 LexA repressor; Validated; Region: PRK00215 1045856000913 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 1045856000914 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1045856000915 Catalytic site [active] 1045856000916 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 1045856000917 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 1045856000918 hypothetical protein; Provisional; Region: PRK10428 1045856000919 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1045856000920 metal binding site 2 [ion binding]; metal-binding site 1045856000921 putative DNA binding helix; other site 1045856000922 metal binding site 1 [ion binding]; metal-binding site 1045856000923 dimer interface [polypeptide binding]; other site 1045856000924 structural Zn2+ binding site [ion binding]; other site 1045856000925 Cupin domain; Region: Cupin_2; cl17218 1045856000926 F plasmid transfer operon, TraF, protein; Region: TraF_2; pfam13729 1045856000927 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 1045856000928 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1045856000929 FMN binding site [chemical binding]; other site 1045856000930 active site 1045856000931 catalytic residues [active] 1045856000932 substrate binding site [chemical binding]; other site 1045856000933 phage shock protein G; Reviewed; Region: pspG; PRK09459 1045856000934 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 1045856000935 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 1045856000936 NADP binding site [chemical binding]; other site 1045856000937 dimer interface [polypeptide binding]; other site 1045856000938 replicative DNA helicase; Provisional; Region: PRK08006 1045856000939 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1045856000940 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1045856000941 Walker A motif; other site 1045856000942 ATP binding site [chemical binding]; other site 1045856000943 Walker B motif; other site 1045856000944 DNA binding loops [nucleotide binding] 1045856000945 alanine racemase; Reviewed; Region: alr; PRK00053 1045856000946 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 1045856000947 active site 1045856000948 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1045856000949 substrate binding site [chemical binding]; other site 1045856000950 catalytic residues [active] 1045856000951 dimer interface [polypeptide binding]; other site 1045856000952 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 1045856000953 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1045856000954 active site 1045856000955 nucleotide binding site [chemical binding]; other site 1045856000956 HIGH motif; other site 1045856000957 KMSKS motif; other site 1045856000958 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 1045856000959 AAA domain; Region: AAA_28; pfam13521 1045856000960 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 1045856000961 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1045856000962 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1045856000963 homodimer interface [polypeptide binding]; other site 1045856000964 catalytic residue [active] 1045856000965 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1045856000966 active site 1045856000967 motif I; other site 1045856000968 motif II; other site 1045856000969 Uncharacterized conserved protein [Function unknown]; Region: COG0432 1045856000970 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 1045856000971 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1045856000972 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1045856000973 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1045856000974 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1045856000975 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1045856000976 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1045856000977 dimer interface [polypeptide binding]; other site 1045856000978 ssDNA binding site [nucleotide binding]; other site 1045856000979 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1045856000980 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 1045856000981 PAS domain S-box; Region: sensory_box; TIGR00229 1045856000982 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1045856000983 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1045856000984 metal binding site [ion binding]; metal-binding site 1045856000985 active site 1045856000986 I-site; other site 1045856000987 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 1045856000988 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 1045856000989 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1045856000990 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 1045856000991 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1045856000992 redox-sensitivie transcriptional activator SoxR; Provisional; Region: PRK15002 1045856000993 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 1045856000994 DNA binding residues [nucleotide binding] 1045856000995 dimer interface [polypeptide binding]; other site 1045856000996 [2Fe-2S] cluster binding site [ion binding]; other site 1045856000997 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1045856000998 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 1045856000999 putative C-terminal domain interface [polypeptide binding]; other site 1045856001000 putative GSH binding site (G-site) [chemical binding]; other site 1045856001001 putative dimer interface [polypeptide binding]; other site 1045856001002 C-terminal, alpha helical domain of GTT1-like Glutathione S-transferases; Region: GST_C_GTT1_like; cd03189 1045856001003 putative N-terminal domain interface [polypeptide binding]; other site 1045856001004 putative dimer interface [polypeptide binding]; other site 1045856001005 putative substrate binding pocket (H-site) [chemical binding]; other site 1045856001006 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1045856001007 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 1045856001008 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 1045856001009 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1045856001010 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1045856001011 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 1045856001012 putative dimerization interface [polypeptide binding]; other site 1045856001013 Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380 1045856001014 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 1045856001015 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 1045856001016 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 1045856001017 Na binding site [ion binding]; other site 1045856001018 Predicted membrane protein [Function unknown]; Region: COG3162 1045856001019 acetyl-CoA synthetase; Provisional; Region: PRK00174 1045856001020 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 1045856001021 active site 1045856001022 CoA binding site [chemical binding]; other site 1045856001023 acyl-activating enzyme (AAE) consensus motif; other site 1045856001024 AMP binding site [chemical binding]; other site 1045856001025 acetate binding site [chemical binding]; other site 1045856001026 glutamate/aspartate:proton symporter; Provisional; Region: gltP; PRK11283 1045856001027 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1045856001028 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1045856001029 Sel1-like repeats; Region: SEL1; smart00671 1045856001030 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1045856001031 molybdopterin cofactor binding site; other site 1045856001032 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790 1045856001033 molybdopterin cofactor binding site; other site 1045856001034 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1045856001035 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1045856001036 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1045856001037 active site 1045856001038 phosphorylation site [posttranslational modification] 1045856001039 intermolecular recognition site; other site 1045856001040 dimerization interface [polypeptide binding]; other site 1045856001041 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1045856001042 DNA binding site [nucleotide binding] 1045856001043 Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168 1045856001044 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1045856001045 substrate binding site [chemical binding]; other site 1045856001046 ATP binding site [chemical binding]; other site 1045856001047 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1045856001048 intersubunit interface [polypeptide binding]; other site 1045856001049 active site 1045856001050 zinc binding site [ion binding]; other site 1045856001051 Na+ binding site [ion binding]; other site 1045856001052 Protein of unknown function (DUF1498); Region: DUF1498; cl17840 1045856001053 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 1045856001054 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_11; cd06321 1045856001055 putative ligand binding site [chemical binding]; other site 1045856001056 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1045856001057 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1045856001058 TM-ABC transporter signature motif; other site 1045856001059 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1045856001060 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1045856001061 Walker A/P-loop; other site 1045856001062 ATP binding site [chemical binding]; other site 1045856001063 Q-loop/lid; other site 1045856001064 ABC transporter signature motif; other site 1045856001065 Walker B; other site 1045856001066 D-loop; other site 1045856001067 H-loop/switch region; other site 1045856001068 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1045856001069 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1045856001070 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1045856001071 dimerization interface [polypeptide binding]; other site 1045856001072 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1045856001073 dimer interface [polypeptide binding]; other site 1045856001074 phosphorylation site [posttranslational modification] 1045856001075 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1045856001076 ATP binding site [chemical binding]; other site 1045856001077 Mg2+ binding site [ion binding]; other site 1045856001078 G-X-G motif; other site 1045856001079 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1045856001080 Response regulator receiver domain; Region: Response_reg; pfam00072 1045856001081 active site 1045856001082 phosphorylation site [posttranslational modification] 1045856001083 intermolecular recognition site; other site 1045856001084 dimerization interface [polypeptide binding]; other site 1045856001085 D-allose kinase; Provisional; Region: PRK09698 1045856001086 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1045856001087 nucleotide binding site [chemical binding]; other site 1045856001088 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1045856001089 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 1045856001090 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1045856001091 substrate binding site [chemical binding]; other site 1045856001092 hexamer interface [polypeptide binding]; other site 1045856001093 metal binding site [ion binding]; metal-binding site 1045856001094 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1045856001095 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1045856001096 TM-ABC transporter signature motif; other site 1045856001097 D-allose transporter ATP-binding protein; Provisional; Region: PRK09700 1045856001098 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1045856001099 Walker A/P-loop; other site 1045856001100 ATP binding site [chemical binding]; other site 1045856001101 Q-loop/lid; other site 1045856001102 ABC transporter signature motif; other site 1045856001103 Walker B; other site 1045856001104 D-loop; other site 1045856001105 H-loop/switch region; other site 1045856001106 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1045856001107 D-allose transporter subunit; Provisional; Region: PRK09701 1045856001108 Periplasmic allose-binding domain of bacterial transport systems that function as a primary receptor of active transport and chemotaxis; Region: PBP1_allose_binding; cd06320 1045856001109 ligand binding site [chemical binding]; other site 1045856001110 dimerization interface [polypeptide binding]; other site 1045856001111 zinc binding site [ion binding]; other site 1045856001112 DNA-binding transcriptional repressor RpiR; Provisional; Region: PRK11337 1045856001113 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1045856001114 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1045856001115 putative active site [active] 1045856001116 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 1045856001117 putative hydrolase; Provisional; Region: PRK02113 1045856001118 carbon-phosphorus lyase complex accessory protein; Provisional; Region: phnP; PRK11244 1045856001119 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1045856001120 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1045856001121 Coenzyme A binding pocket [chemical binding]; other site 1045856001122 ribose 1,5-bisphosphokinase; Provisional; Region: PRK10078 1045856001123 AAA domain; Region: AAA_18; pfam13238 1045856001124 active site 1045856001125 phosphonate metabolism protein PhnM; Provisional; Region: PRK15446 1045856001126 PhnM is believed to be a subunit of the membrane associated C-P lyase complex. C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage...; Region: PhnM; cd01306 1045856001127 active site 1045856001128 ABC-type phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PhnL; COG4778 1045856001129 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1045856001130 Walker A/P-loop; other site 1045856001131 ATP binding site [chemical binding]; other site 1045856001132 Q-loop/lid; other site 1045856001133 ABC transporter signature motif; other site 1045856001134 Walker B; other site 1045856001135 D-loop; other site 1045856001136 H-loop/switch region; other site 1045856001137 phosphonate C-P lyase system protein PhnK; Provisional; Region: phnK; PRK11701 1045856001138 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1045856001139 Walker A/P-loop; other site 1045856001140 ATP binding site [chemical binding]; other site 1045856001141 Q-loop/lid; other site 1045856001142 ABC transporter signature motif; other site 1045856001143 Walker B; other site 1045856001144 D-loop; other site 1045856001145 H-loop/switch region; other site 1045856001146 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1045856001147 Phosphonate metabolism protein PhnJ; Region: PhnJ; pfam06007 1045856001148 Bacterial phosphonate metabolism protein (PhnI); Region: PhnI; pfam05861 1045856001149 carbon-phosphorus lyase complex subunit; Validated; Region: phnH; PRK10147 1045856001150 Phosphonate metabolism protein PhnG; Region: PhnG; pfam06754 1045856001151 phosphonate metabolism transcriptional regulator PhnF; Provisional; Region: PRK10079 1045856001152 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1045856001153 DNA-binding site [nucleotide binding]; DNA binding site 1045856001154 UTRA domain; Region: UTRA; pfam07702 1045856001155 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 1045856001156 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1045856001157 dimer interface [polypeptide binding]; other site 1045856001158 conserved gate region; other site 1045856001159 putative PBP binding loops; other site 1045856001160 ABC-ATPase subunit interface; other site 1045856001161 phosphonate ABC transporter, periplasmic phosphonate binding protein; Region: PhnD; TIGR03431 1045856001162 phosphonate/organophosphate ester transporter subunit; Provisional; Region: PRK09984 1045856001163 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 1045856001164 Walker A/P-loop; other site 1045856001165 ATP binding site [chemical binding]; other site 1045856001166 Q-loop/lid; other site 1045856001167 ABC transporter signature motif; other site 1045856001168 Walker B; other site 1045856001169 D-loop; other site 1045856001170 H-loop/switch region; other site 1045856001171 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1045856001172 dimer interface [polypeptide binding]; other site 1045856001173 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1045856001174 hypothetical protein; Provisional; Region: PRK10220 1045856001175 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 1045856001176 PhnA protein; Region: PhnA; pfam03831 1045856001177 hypothetical protein; Provisional; Region: PRK09866 1045856001178 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1045856001179 G1 box; other site 1045856001180 GTP/Mg2+ binding site [chemical binding]; other site 1045856001181 G2 box; other site 1045856001182 Switch I region; other site 1045856001183 G3 box; other site 1045856001184 Switch II region; other site 1045856001185 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 1045856001186 G2 box; other site 1045856001187 Switch I region; other site 1045856001188 G3 box; other site 1045856001189 Switch II region; other site 1045856001190 G4 box; other site 1045856001191 G5 box; other site 1045856001192 YjcZ-like protein; Region: YjcZ; pfam13990 1045856001193 2-keto-3-deoxygluconate permease; Region: KdgT; cl14653 1045856001194 proline/glycine betaine transporter; Provisional; Region: PRK10642 1045856001195 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1045856001196 putative substrate translocation pore; other site 1045856001197 Osmosensory transporter coiled coil; Region: Osmo_CC; pfam08946 1045856001198 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG2215 1045856001199 putative transcriptional regulator; Provisional; Region: PRK11640 1045856001200 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 1045856001201 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 1045856001202 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1045856001203 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 1045856001204 DsbD alpha interface [polypeptide binding]; other site 1045856001205 catalytic residues [active] 1045856001206 divalent-cation tolerance protein CutA; Provisional; Region: PRK10645 1045856001207 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 1045856001208 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 1045856001209 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 1045856001210 Aspartase; Region: Aspartase; cd01357 1045856001211 active sites [active] 1045856001212 tetramer interface [polypeptide binding]; other site 1045856001213 Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030 1045856001214 putative transporter; Provisional; Region: PRK11021 1045856001215 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1045856001216 oligomerisation interface [polypeptide binding]; other site 1045856001217 mobile loop; other site 1045856001218 roof hairpin; other site 1045856001219 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1045856001220 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1045856001221 ring oligomerisation interface [polypeptide binding]; other site 1045856001222 ATP/Mg binding site [chemical binding]; other site 1045856001223 stacking interactions; other site 1045856001224 hinge regions; other site 1045856001225 Domain of unknown function (DUF4156); Region: DUF4156; pfam13698 1045856001226 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 1045856001227 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1045856001228 FeS/SAM binding site; other site 1045856001229 elongation factor P; Validated; Region: PRK00529 1045856001230 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1045856001231 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1045856001232 RNA binding site [nucleotide binding]; other site 1045856001233 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1045856001234 RNA binding site [nucleotide binding]; other site 1045856001235 Predicted small secreted protein [Function unknown]; Region: COG5510 1045856001236 entericidin B membrane lipoprotein; Provisional; Region: PRK10081 1045856001237 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1045856001238 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1045856001239 DNA binding residues [nucleotide binding] 1045856001240 dimerization interface [polypeptide binding]; other site 1045856001241 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 1045856001242 outer membrane lipoprotein Blc; Provisional; Region: PRK10477 1045856001243 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 1045856001244 beta-lactamase/D-alanine carboxypeptidase; Provisional; Region: ampC; PRK11289 1045856001245 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1045856001246 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1045856001247 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1045856001248 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1045856001249 dimerization interface [polypeptide binding]; other site 1045856001250 Quinol:fumarate reductase (QFR) Type D subfamily, 13kD hydrophobic subunit D; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitD; cd00547 1045856001251 Iron-sulfur protein interface; other site 1045856001252 proximal quinone binding site [chemical binding]; other site 1045856001253 C-subunit interface; other site 1045856001254 distal quinone binding site; other site 1045856001255 Quinol:fumarate reductase (QFR) Type D subfamily, 15kD hydrophobic subunit C; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitC; cd00546 1045856001256 D-subunit interface [polypeptide binding]; other site 1045856001257 Iron-sulfur protein interface; other site 1045856001258 proximal quinone binding site [chemical binding]; other site 1045856001259 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12385 1045856001260 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1045856001261 fumarate reductase flavoprotein subunit; Validated; Region: PRK09231 1045856001262 L-aspartate oxidase; Provisional; Region: PRK06175 1045856001263 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1045856001264 poxB regulator PoxA; Provisional; Region: PRK09350 1045856001265 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1045856001266 motif 1; other site 1045856001267 dimer interface [polypeptide binding]; other site 1045856001268 active site 1045856001269 motif 2; other site 1045856001270 motif 3; other site 1045856001271 inner membrane transporter YjeM; Provisional; Region: PRK15238 1045856001272 putative mechanosensitive channel protein; Provisional; Region: PRK10929 1045856001273 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 1045856001274 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 1045856001275 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1045856001276 phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044 1045856001277 GTPase RsgA; Reviewed; Region: PRK12288 1045856001278 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1045856001279 RNA binding site [nucleotide binding]; other site 1045856001280 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1045856001281 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1045856001282 GTP/Mg2+ binding site [chemical binding]; other site 1045856001283 G4 box; other site 1045856001284 G5 box; other site 1045856001285 G1 box; other site 1045856001286 Switch I region; other site 1045856001287 G2 box; other site 1045856001288 G3 box; other site 1045856001289 Switch II region; other site 1045856001290 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 1045856001291 catalytic site [active] 1045856001292 putative active site [active] 1045856001293 putative substrate binding site [chemical binding]; other site 1045856001294 dimer interface [polypeptide binding]; other site 1045856001295 epoxyqueuosine reductase; Region: TIGR00276 1045856001296 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 1045856001297 putative carbohydrate kinase; Provisional; Region: PRK10565 1045856001298 Uncharacterized conserved protein [Function unknown]; Region: COG0062 1045856001299 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 1045856001300 putative substrate binding site [chemical binding]; other site 1045856001301 putative ATP binding site [chemical binding]; other site 1045856001302 ADP-binding protein; Provisional; Region: PRK10646 1045856001303 N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431 1045856001304 AMIN domain; Region: AMIN; pfam11741 1045856001305 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1045856001306 active site 1045856001307 metal binding site [ion binding]; metal-binding site 1045856001308 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 1045856001309 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1045856001310 ATP binding site [chemical binding]; other site 1045856001311 Mg2+ binding site [ion binding]; other site 1045856001312 G-X-G motif; other site 1045856001313 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 1045856001314 ATP binding site [chemical binding]; other site 1045856001315 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 1045856001316 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 1045856001317 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1045856001318 bacterial Hfq-like; Region: Hfq; cd01716 1045856001319 hexamer interface [polypeptide binding]; other site 1045856001320 Sm1 motif; other site 1045856001321 RNA binding site [nucleotide binding]; other site 1045856001322 Sm2 motif; other site 1045856001323 GTPase HflX; Provisional; Region: PRK11058 1045856001324 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1045856001325 HflX GTPase family; Region: HflX; cd01878 1045856001326 G1 box; other site 1045856001327 GTP/Mg2+ binding site [chemical binding]; other site 1045856001328 Switch I region; other site 1045856001329 G2 box; other site 1045856001330 G3 box; other site 1045856001331 Switch II region; other site 1045856001332 G4 box; other site 1045856001333 G5 box; other site 1045856001334 FtsH protease regulator HflK; Provisional; Region: PRK10930 1045856001335 Bacterial membrane protein N terminal; Region: HflK_N; pfam12221 1045856001336 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 1045856001337 FtsH protease regulator HflC; Provisional; Region: PRK11029 1045856001338 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 1045856001339 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3242 1045856001340 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1045856001341 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1045856001342 GDP-binding site [chemical binding]; other site 1045856001343 ACT binding site; other site 1045856001344 IMP binding site; other site 1045856001345 Predicted transcriptional regulator [Transcription]; Region: COG1959 1045856001346 transcriptional repressor NsrR; Provisional; Region: PRK11014 1045856001347 exoribonuclease R; Provisional; Region: PRK11642 1045856001348 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 1045856001349 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1045856001350 RNB domain; Region: RNB; pfam00773 1045856001351 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 1045856001352 RNA binding site [nucleotide binding]; other site 1045856001353 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 1045856001354 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 1045856001355 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1045856001356 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1045856001357 metabolite-proton symporter; Region: 2A0106; TIGR00883 1045856001358 putative substrate translocation pore; other site 1045856001359 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 1045856001360 Proteins involved in DNA damage response, similar to the AidB gene product; Region: AidB; cd01154 1045856001361 FAD binding site [chemical binding]; other site 1045856001362 substrate binding site [chemical binding]; other site 1045856001363 catalytic residues [active] 1045856001364 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1045856001365 dimerization interface [polypeptide binding]; other site 1045856001366 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1045856001367 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1045856001368 dimer interface [polypeptide binding]; other site 1045856001369 putative CheW interface [polypeptide binding]; other site 1045856001370 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1045856001371 putative biofilm stress and motility protein A; Provisional; Region: PRK14864 1045856001372 esterase; Provisional; Region: PRK10566 1045856001373 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1045856001374 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1045856001375 transcriptional repressor UlaR; Provisional; Region: PRK13509 1045856001376 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1045856001377 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1045856001378 putative L-ascorbate 6-phosphate lactonase; Provisional; Region: PRK11709 1045856001379 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1045856001380 Uncharacterized protein conserved in bacteria [Function unknown]; Region: SgaT; COG3037 1045856001381 PTS system ascorbate-specific transporter subunits IICB; Provisional; Region: PRK09548 1045856001382 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 1045856001383 active site 1045856001384 P-loop; other site 1045856001385 phosphorylation site [posttranslational modification] 1045856001386 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1045856001387 active site 1045856001388 phosphorylation site [posttranslational modification] 1045856001389 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 1045856001390 active site 1045856001391 dimer interface [polypeptide binding]; other site 1045856001392 magnesium binding site [ion binding]; other site 1045856001393 L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13209 1045856001394 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 1045856001395 AP (apurinic/apyrimidinic) site pocket; other site 1045856001396 DNA interaction; other site 1045856001397 Metal-binding active site; metal-binding site 1045856001398 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 1045856001399 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 1045856001400 intersubunit interface [polypeptide binding]; other site 1045856001401 active site 1045856001402 Zn2+ binding site [ion binding]; other site 1045856001403 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 1045856001404 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 1045856001405 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1045856001406 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1045856001407 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1045856001408 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1045856001409 EamA-like transporter family; Region: EamA; pfam00892 1045856001410 EamA-like transporter family; Region: EamA; pfam00892 1045856001411 Cell envelope opacity-associated protein A [Cell envelope biogenesis, outer membrane]; Region: OapA; COG3061 1045856001412 Opacity-associated protein A N-terminal motif; Region: OapA_N; pfam08525 1045856001413 Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225 1045856001414 peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK11570 1045856001415 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 1045856001416 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1045856001417 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 1045856001418 iron-sulfur cluster repair di-iron protein; Provisional; Region: PRK10992 1045856001419 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 1045856001420 Hemerythrin-like domain; Region: Hr-like; cd12108 1045856001421 Fe binding site [ion binding]; other site 1045856001422 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 1045856001423 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 1045856001424 dimer interface [polypeptide binding]; other site 1045856001425 ligand binding site [chemical binding]; other site 1045856001426 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1045856001427 dimerization interface [polypeptide binding]; other site 1045856001428 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1045856001429 dimer interface [polypeptide binding]; other site 1045856001430 putative CheW interface [polypeptide binding]; other site 1045856001431 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1045856001432 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1045856001433 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1045856001434 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1045856001435 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1045856001436 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1045856001437 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 1045856001438 NADP binding site [chemical binding]; other site 1045856001439 Predicted transcriptional regulators [Transcription]; Region: COG1733 1045856001440 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1045856001441 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420 1045856001442 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 1045856001443 active site 1045856001444 metal binding site [ion binding]; metal-binding site 1045856001445 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1045856001446 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 1045856001447 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1045856001448 active site 1045856001449 Bacterial protein of unknown function (YtfJ_HI0045); Region: YtfJ_HI0045; cl17398 1045856001450 Protein of unknown function (DUF1107); Region: DUF1107; pfam06526 1045856001451 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1045856001452 Domain of unknown function DUF21; Region: DUF21; pfam01595 1045856001453 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1045856001454 Transporter associated domain; Region: CorC_HlyC; smart01091 1045856001455 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 1045856001456 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 1045856001457 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1045856001458 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1045856001459 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1045856001460 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1045856001461 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1045856001462 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1045856001463 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1045856001464 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1045856001465 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1045856001466 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1045856001467 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1045856001468 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1045856001469 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1045856001470 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1045856001471 DNA binding site [nucleotide binding] 1045856001472 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1045856001473 ligand binding site [chemical binding]; other site 1045856001474 dimerization interface [polypeptide binding]; other site 1045856001475 methionine sulfoxide reductase A; Provisional; Region: PRK00058 1045856001476 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 1045856001477 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1045856001478 Surface antigen; Region: Bac_surface_Ag; pfam01103 1045856001479 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 1045856001480 Family of unknown function (DUF490); Region: DUF490; pfam04357 1045856001481 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1045856001482 putative active site pocket [active] 1045856001483 dimerization interface [polypeptide binding]; other site 1045856001484 putative catalytic residue [active] 1045856001485 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 1045856001486 dimer interface [polypeptide binding]; other site 1045856001487 substrate binding site [chemical binding]; other site 1045856001488 metal binding sites [ion binding]; metal-binding site 1045856001489 Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309 1045856001490 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1045856001491 putative ligand binding site [chemical binding]; other site 1045856001492 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1045856001493 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1045856001494 Walker A/P-loop; other site 1045856001495 ATP binding site [chemical binding]; other site 1045856001496 Q-loop/lid; other site 1045856001497 ABC transporter signature motif; other site 1045856001498 Walker B; other site 1045856001499 D-loop; other site 1045856001500 H-loop/switch region; other site 1045856001501 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1045856001502 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1045856001503 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1045856001504 TM-ABC transporter signature motif; other site 1045856001505 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1045856001506 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1045856001507 TM-ABC transporter signature motif; other site 1045856001508 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 1045856001509 dimer interface [polypeptide binding]; other site 1045856001510 ligand binding site [chemical binding]; other site 1045856001511 HAMP domain; Region: HAMP; pfam00672 1045856001512 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1045856001513 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1045856001514 dimer interface [polypeptide binding]; other site 1045856001515 putative CheW interface [polypeptide binding]; other site 1045856001516 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1045856001517 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1045856001518 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 1045856001519 AMP binding site [chemical binding]; other site 1045856001520 metal binding site [ion binding]; metal-binding site 1045856001521 active site 1045856001522 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 1045856001523 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1045856001524 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1045856001525 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1045856001526 hypothetical protein; Provisional; Region: PRK05255 1045856001527 peptidase PmbA; Provisional; Region: PRK11040 1045856001528 cytochrome b562; Provisional; Region: PRK15058 1045856001529 PRD domain protein EF_0829/AHA_3910; Region: EF_0829; TIGR03582 1045856001530 Glycine-rich SFCGS; Region: Gly_rich_SFCGS; pfam14272 1045856001531 conserved hypothetical protein EF_0831/AHA_3912; Region: EF_0831; TIGR03578 1045856001532 conserved hypothetical protein EF_0832/AHA_3913; Region: EF_0832; TIGR03580 1045856001533 conserved hypothetical protein EF_0833/AHA_3914; Region: EF_0833; TIGR03579 1045856001534 dihydroorotase; Provisional; Region: PRK09237 1045856001535 Metallo-dependent hydrolases, subgroup B is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_B; cd01307 1045856001536 active site 1045856001537 uncharacterized pyridoxal phosphate-dependent enzyme; Region: selA_rel; TIGR01437 1045856001538 conserved hypothetical protein EF_0839/AHA_3917; Region: EF_0839; TIGR03581 1045856001539 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 1045856001540 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1045856001541 HTH domain; Region: HTH_11; pfam08279 1045856001542 Mga helix-turn-helix domain; Region: Mga; pfam05043 1045856001543 PRD domain; Region: PRD; pfam00874 1045856001544 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1045856001545 active site 1045856001546 P-loop; other site 1045856001547 phosphorylation site [posttranslational modification] 1045856001548 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1045856001549 active site 1045856001550 phosphorylation site [posttranslational modification] 1045856001551 bifunctional antitoxin/transcriptional repressor RelB; Provisional; Region: PRK11235 1045856001552 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491 1045856001553 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1045856001554 FeS/SAM binding site; other site 1045856001555 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 1045856001556 ATP cone domain; Region: ATP-cone; pfam03477 1045856001557 Class III ribonucleotide reductase; Region: RNR_III; cd01675 1045856001558 effector binding site; other site 1045856001559 active site 1045856001560 Zn binding site [ion binding]; other site 1045856001561 glycine loop; other site 1045856001562 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1045856001563 active site 1045856001564 phosphorylation site [posttranslational modification] 1045856001565 alpha-mannosidase; Provisional; Region: PRK09819 1045856001566 N-terminal catalytic domain of Escherichia coli alpha-mannosidase MngB and its bacterial homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_EcMngB_like; cd10815 1045856001567 active site 1045856001568 metal binding site [ion binding]; metal-binding site 1045856001569 catalytic site [active] 1045856001570 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; cl08536 1045856001571 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 1045856001572 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1045856001573 active site 1045856001574 P-loop; other site 1045856001575 phosphorylation site [posttranslational modification] 1045856001576 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 1045856001577 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1045856001578 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1045856001579 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1045856001580 putative active site [active] 1045856001581 Oligogalacturonate-specific porin protein (KdgM); Region: KdgM; cl11629 1045856001582 trehalose-6-phosphate hydrolase; Provisional; Region: PRK10933 1045856001583 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1045856001584 Ca binding site [ion binding]; other site 1045856001585 active site 1045856001586 catalytic site [active] 1045856001587 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 1045856001588 PTS system trehalose(maltose)-specific transporter subunits IIBC; Provisional; Region: PRK11007 1045856001589 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1045856001590 active site turn [active] 1045856001591 phosphorylation site [posttranslational modification] 1045856001592 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1045856001593 trehalose repressor; Provisional; Region: treR; PRK09492 1045856001594 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1045856001595 DNA binding site [nucleotide binding] 1045856001596 domain linker motif; other site 1045856001597 Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542 1045856001598 dimerization interface [polypeptide binding]; other site 1045856001599 ligand binding site [chemical binding]; other site 1045856001600 magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517 1045856001601 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 1045856001602 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1045856001603 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1045856001604 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 1045856001605 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1045856001606 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1045856001607 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 1045856001608 Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides; Region: GH20_hexosaminidase; cl02948 1045856001609 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 1045856001610 active site 1045856001611 Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides; Region: GH20_hexosaminidase; cl02948 1045856001612 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1045856001613 homotrimer interaction site [polypeptide binding]; other site 1045856001614 putative active site [active] 1045856001615 aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893 1045856001616 Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948 1045856001617 Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748 1045856001618 Aspartate carbamoyltransferase, catalytic chain [Nucleotide transport and metabolism]; Region: PyrB; COG0540 1045856001619 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1045856001620 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1045856001621 Arginine repressor [Transcription]; Region: ArgR; COG1438 1045856001622 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1045856001623 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1045856001624 Predicted membrane protein [Function unknown]; Region: COG1288 1045856001625 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 1045856001626 ornithine carbamoyltransferase; Validated; Region: PRK02102 1045856001627 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1045856001628 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1045856001629 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1045856001630 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 1045856001631 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 1045856001632 putative substrate binding site [chemical binding]; other site 1045856001633 nucleotide binding site [chemical binding]; other site 1045856001634 nucleotide binding site [chemical binding]; other site 1045856001635 homodimer interface [polypeptide binding]; other site 1045856001636 arginine deiminase; Provisional; Region: PRK01388 1045856001637 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 1045856001638 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1045856001639 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 1045856001640 inhibitor site; inhibition site 1045856001641 active site 1045856001642 dimer interface [polypeptide binding]; other site 1045856001643 catalytic residue [active] 1045856001644 putative dehydratase; Provisional; Region: PRK08211 1045856001645 Dehydratase family; Region: ILVD_EDD; cl00340 1045856001646 putative symporter YagG; Provisional; Region: PRK09669 1045856001647 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 1045856001648 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 1045856001649 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 1045856001650 inhibitor binding site; inhibition site 1045856001651 active site 1045856001652 Protein of unknown function (DUF1349); Region: DUF1349; cl01397 1045856001653 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1045856001654 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1045856001655 Bacterial transcriptional regulator; Region: IclR; pfam01614 1045856001656 ornithine carbamoyltransferase subunit I; Provisional; Region: PRK03515 1045856001657 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1045856001658 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1045856001659 RNase E inhibitor protein; Provisional; Region: PRK11191 1045856001660 MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910 1045856001661 active site 1045856001662 dinuclear metal binding site [ion binding]; other site 1045856001663 dimerization interface [polypeptide binding]; other site 1045856001664 integrase; Provisional; Region: PRK09692 1045856001665 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 1045856001666 active site 1045856001667 Int/Topo IB signature motif; other site 1045856001668 Protein of unknown function (DUF511); Region: DUF511; pfam04373 1045856001669 Restriction endonuclease; Region: Mrr_cat; pfam04471 1045856001670 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 1045856001671 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 1045856001672 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1045856001673 ATP binding site [chemical binding]; other site 1045856001674 putative Mg++ binding site [ion binding]; other site 1045856001675 AAA domain; Region: AAA_13; pfam13166 1045856001676 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1045856001677 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 1045856001678 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1045856001679 type I restriction system adenine methylase (hsdM); Region: hsdM; TIGR00497 1045856001680 HsdM N-terminal domain; Region: HsdM_N; pfam12161 1045856001681 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1045856001682 S-adenosylmethionine binding site [chemical binding]; other site 1045856001683 Methyltransferase domain; Region: Methyltransf_27; pfam13708 1045856001684 Predicted restriction endonuclease [Defense mechanisms]; Region: COG3440 1045856001685 HNH endonuclease; Region: HNH_2; pfam13391 1045856001686 Toxin SymE, type I toxin-antitoxin system; Region: SymE_toxin; cl07446 1045856001687 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 1045856001688 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1045856001689 S-adenosylmethionine binding site [chemical binding]; other site 1045856001690 hypothetical protein; Provisional; Region: PRK13687 1045856001691 Protein of unknown function (DUF1349); Region: DUF1349; pfam07081 1045856001692 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1045856001693 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1045856001694 DNA binding site [nucleotide binding] 1045856001695 domain linker motif; other site 1045856001696 Ligand-binding domain of DNA-binding regulatory proteins specific to sucrose that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_sucrose_transcription_regulator; cd06288 1045856001697 putative dimerization interface [polypeptide binding]; other site 1045856001698 putative ligand binding site [chemical binding]; other site 1045856001699 galactoside permease; Reviewed; Region: lacY; PRK09528 1045856001700 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1045856001701 putative substrate translocation pore; other site 1045856001702 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 1045856001703 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 1045856001704 substrate binding [chemical binding]; other site 1045856001705 active site 1045856001706 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 1045856001707 Glycosyl hydrolase family 32; Region: GH32_Aec43_like; cd08995 1045856001708 active site 1045856001709 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1045856001710 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 1045856001711 putative substrate binding site [chemical binding]; other site 1045856001712 putative ATP binding site [chemical binding]; other site 1045856001713 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1045856001714 guanine deaminase; Region: guan_deamin; TIGR02967 1045856001715 active site 1045856001716 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1045856001717 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1045856001718 active site 1045856001719 HIGH motif; other site 1045856001720 dimer interface [polypeptide binding]; other site 1045856001721 KMSKS motif; other site 1045856001722 fosfomycin resistance protein FosB; Provisional; Region: PRK04101 1045856001723 FosA, a Fosfomycin resistance protein, catalyzes the addition of glutathione to the antibiotic fosfomycin, making it inactive; Region: FosA; cd07244 1045856001724 dimer interface [polypeptide binding]; other site 1045856001725 Mn binding site [ion binding]; other site 1045856001726 K binding site [ion binding]; other site 1045856001727 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1045856001728 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1045856001729 DNA binding site [nucleotide binding] 1045856001730 domain linker motif; other site 1045856001731 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1045856001732 Sugar-binding cellulase-like; Region: Cellulase-like; pfam12876 1045856001733 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 1045856001734 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 1045856001735 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1045856001736 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1045856001737 active site 1045856001738 metal binding site [ion binding]; metal-binding site 1045856001739 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1045856001740 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1045856001741 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1045856001742 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 1045856001743 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1045856001744 oligomer interface [polypeptide binding]; other site 1045856001745 active site residues [active] 1045856001746 Uncharacterized conserved protein [Function unknown]; Region: COG2850 1045856001747 Helix-turn-helix domain; Region: HTH_18; pfam12833 1045856001748 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 1045856001749 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1045856001750 N-terminal plug; other site 1045856001751 ligand-binding site [chemical binding]; other site 1045856001752 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1045856001753 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1045856001754 DNA-binding site [nucleotide binding]; DNA binding site 1045856001755 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1045856001756 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1045856001757 homodimer interface [polypeptide binding]; other site 1045856001758 catalytic residue [active] 1045856001759 Uncharacterized conserved small protein [Function unknown]; Region: COG5457 1045856001760 Domain of unknown function (DUF4282); Region: DUF4282; pfam14110 1045856001761 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1045856001762 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1045856001763 DNA-binding site [nucleotide binding]; DNA binding site 1045856001764 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1045856001765 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1045856001766 homodimer interface [polypeptide binding]; other site 1045856001767 catalytic residue [active] 1045856001768 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1045856001769 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1045856001770 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1045856001771 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1045856001772 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 1045856001773 putative effector binding pocket; other site 1045856001774 putative dimerization interface [polypeptide binding]; other site 1045856001775 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 1045856001776 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1045856001777 NAD binding site [chemical binding]; other site 1045856001778 catalytic residues [active] 1045856001779 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 1045856001780 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1045856001781 dimerization interface [polypeptide binding]; other site 1045856001782 putative DNA binding site [nucleotide binding]; other site 1045856001783 putative Zn2+ binding site [ion binding]; other site 1045856001784 transcriptional regulator SlyA; Provisional; Region: PRK03573 1045856001785 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 1045856001786 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 1045856001787 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1045856001788 Protein of unknown function (DUF2955); Region: DUF2955; pfam11168 1045856001789 Protein of unknown function (DUF445); Region: DUF445; pfam04286 1045856001790 LysE type translocator; Region: LysE; cl00565 1045856001791 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1045856001792 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1045856001793 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1045856001794 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 1045856001795 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 1045856001796 NAD(P) binding site [chemical binding]; other site 1045856001797 catalytic residues [active] 1045856001798 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cl00304 1045856001799 YfaZ precursor; Region: YfaZ; pfam07437 1045856001800 outer membrane protein; Region: OMP_w_GlyGly; TIGR04219 1045856001801 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 1045856001802 putative GTP-binding protein YjiA; Provisional; Region: PRK11537 1045856001803 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 1045856001804 P-loop, Walker A motif; other site 1045856001805 Base recognition motif; other site 1045856001806 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 1045856001807 Uncharacterized small protein [Function unknown]; Region: COG2879 1045856001808 carbon starvation protein A; Provisional; Region: PRK15015 1045856001809 Carbon starvation protein CstA; Region: CstA; pfam02554 1045856001810 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 1045856001811 Predicted transcriptional regulator [Transcription]; Region: COG2378 1045856001812 HTH domain; Region: HTH_11; cl17392 1045856001813 WYL domain; Region: WYL; pfam13280 1045856001814 Flavin Reductases; Region: FlaRed; cl00801 1045856001815 4-hydroxyphenylacetate 3-monooxygenase, oxygenase component; Region: HpaB-2; TIGR02310 1045856001816 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 1045856001817 4-hydroxyphenylacetate catabolism regulatory protein HpaA; Region: HpaA; TIGR02297 1045856001818 Cupin domain; Region: Cupin_2; pfam07883 1045856001819 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1045856001820 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 1045856001821 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1045856001822 putative substrate translocation pore; other site 1045856001823 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 1045856001824 2-oxo-hepta-3-ene-1,7-dioic acid hydratase; Region: HpaH; TIGR02312 1045856001825 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580 1045856001826 putative substrate binding pocket [chemical binding]; other site 1045856001827 trimer interface [polypeptide binding]; other site 1045856001828 The Class III extradiol dioxygenase, homoprotocatechuate 2,3-dioxygenase, catalyzes the key ring cleavage step in the metabolism of homoprotocatechuate; Region: HPCD; cd07370 1045856001829 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 1045856001830 putative active site [active] 1045856001831 putative metal binding site [ion binding]; other site 1045856001832 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase; Region: HpaE; TIGR02299 1045856001833 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 1045856001834 NAD binding site [chemical binding]; other site 1045856001835 catalytic residues [active] 1045856001836 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase; Provisional; Region: PRK15203 1045856001837 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 1045856001838 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1045856001839 homoprotocatechuate degradation operon regulator, HpaR; Region: HpaR; TIGR02337 1045856001840 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1045856001841 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 1045856001842 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 1045856001843 dimer interface [polypeptide binding]; other site 1045856001844 ligand binding site [chemical binding]; other site 1045856001845 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1045856001846 dimerization interface [polypeptide binding]; other site 1045856001847 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1045856001848 dimer interface [polypeptide binding]; other site 1045856001849 putative CheW interface [polypeptide binding]; other site 1045856001850 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1045856001851 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1045856001852 Coenzyme A binding pocket [chemical binding]; other site 1045856001853 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 1045856001854 DNA binding site [nucleotide binding] 1045856001855 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1045856001856 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1045856001857 DNA binding residues [nucleotide binding] 1045856001858 dimerization interface [polypeptide binding]; other site 1045856001859 phosphoglycerol transferase I; Provisional; Region: PRK03776 1045856001860 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 1045856001861 hypothetical protein; Provisional; Region: PRK11667 1045856001862 DNA replication protein DnaC; Validated; Region: PRK07952 1045856001863 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1045856001864 Walker A motif; other site 1045856001865 ATP binding site [chemical binding]; other site 1045856001866 Walker B motif; other site 1045856001867 primosomal protein DnaI; Provisional; Region: PRK02854 1045856001868 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 1045856001869 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1045856001870 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1045856001871 putative Zn2+ binding site [ion binding]; other site 1045856001872 putative DNA binding site [nucleotide binding]; other site 1045856001873 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 1045856001874 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1045856001875 hypothetical protein; Provisional; Region: PRK09917 1045856001876 Uncharacterized conserved protein [Function unknown]; Region: COG2966 1045856001877 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 1045856001878 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1045856001879 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1045856001880 DNA binding residues [nucleotide binding] 1045856001881 dimerization interface [polypeptide binding]; other site 1045856001882 DNA-binding transcriptional activator BglJ; Provisional; Region: PRK11475 1045856001883 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1045856001884 DNA binding residues [nucleotide binding] 1045856001885 dimerization interface [polypeptide binding]; other site 1045856001886 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 1045856001887 putative deacylase active site [active] 1045856001888 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 1045856001889 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1045856001890 ferric iron reductase involved in ferric hydroximate transport; Provisional; Region: PRK10647 1045856001891 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 1045856001892 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 1045856001893 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1045856001894 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1045856001895 metal binding site [ion binding]; metal-binding site 1045856001896 active site 1045856001897 I-site; other site 1045856001898 Protein of unknown function (DUF1435); Region: DUF1435; pfam07256 1045856001899 16S ribosomal RNA m2G1207 methyltransferase; Provisional; Region: rsmC; PRK09489 1045856001900 Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468 1045856001901 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1045856001902 S-adenosylmethionine binding site [chemical binding]; other site 1045856001903 DNA polymerase III subunit psi; Validated; Region: PRK06856 1045856001904 ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491 1045856001905 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1045856001906 dUMP phosphatase; Provisional; Region: PRK09449 1045856001907 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1045856001908 motif II; other site 1045856001909 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 1045856001910 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 1045856001911 G1 box; other site 1045856001912 putative GEF interaction site [polypeptide binding]; other site 1045856001913 GTP/Mg2+ binding site [chemical binding]; other site 1045856001914 Switch I region; other site 1045856001915 G2 box; other site 1045856001916 G3 box; other site 1045856001917 Switch II region; other site 1045856001918 G4 box; other site 1045856001919 G5 box; other site 1045856001920 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 1045856001921 periplasmic protein; Provisional; Region: PRK10568 1045856001922 BON domain; Region: BON; pfam04972 1045856001923 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 1045856001924 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 1045856001925 active site 1045856001926 nucleophile elbow; other site 1045856001927 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1045856001928 active site 1045856001929 glycine radical enzyme activase, YjjW family; Region: activase_YjjW; TIGR04041 1045856001930 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804 1045856001931 hypothetical protein; Provisional; Region: PRK10977 1045856001932 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 1045856001933 intersubunit interface [polypeptide binding]; other site 1045856001934 active site 1045856001935 catalytic residue [active] 1045856001936 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 1045856001937 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1045856001938 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1045856001939 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 1045856001940 phosphopentomutase; Provisional; Region: PRK05362 1045856001941 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 1045856001942 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 1045856001943 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 1045856001944 Protein of unknown function (DUF1120); Region: DUF1120; cl05856 1045856001945 hypothetical protein; Provisional; Region: PRK15301 1045856001946 putative fimbrial outer membrane usher protein; Provisional; Region: PRK15304 1045856001947 PapC N-terminal domain; Region: PapC_N; pfam13954 1045856001948 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1045856001949 PapC C-terminal domain; Region: PapC_C; pfam13953 1045856001950 putative fimbrial chaperone protein; Provisional; Region: PRK09918 1045856001951 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1045856001952 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1045856001953 Protein of unknown function (DUF1120); Region: DUF1120; cl05856 1045856001954 Protein of unknown function (DUF1120); Region: DUF1120; cl05856 1045856001955 Protein of unknown function (DUF1120); Region: DUF1120; cl05856 1045856001956 lipoate-protein ligase A; Provisional; Region: lplA; PRK03822 1045856001957 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1045856001958 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 1045856001959 hypothetical protein; Provisional; Region: PRK11246 1045856001960 phosphoserine phosphatase; Provisional; Region: serB; PRK11133 1045856001961 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1045856001962 motif II; other site 1045856001963 DNA repair protein RadA; Region: sms; TIGR00416 1045856001964 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 1045856001965 Walker A motif/ATP binding site; other site 1045856001966 ATP binding site [chemical binding]; other site 1045856001967 Walker B motif; other site 1045856001968 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1045856001969 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1045856001970 non-specific DNA binding site [nucleotide binding]; other site 1045856001971 salt bridge; other site 1045856001972 bifunctional DNA-binding transcriptional repressor/ NMN adenylyltransferase; Provisional; Region: PRK08099 1045856001973 sequence-specific DNA binding site [nucleotide binding]; other site 1045856001974 Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional NadR-like proteins; Region: NMNAT_NadR; cd02167 1045856001975 active site 1045856001976 (T/H)XGH motif; other site 1045856001977 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 1045856001978 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 1045856001979 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 1045856001980 putative NAD(P) binding site [chemical binding]; other site 1045856001981 dimer interface [polypeptide binding]; other site 1045856001982 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1045856001983 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1045856001984 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1045856001985 putative effector binding pocket; other site 1045856001986 dimerization interface [polypeptide binding]; other site 1045856001987 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 1045856001988 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1045856001989 Walker A/P-loop; other site 1045856001990 ATP binding site [chemical binding]; other site 1045856001991 Q-loop/lid; other site 1045856001992 ABC transporter signature motif; other site 1045856001993 Walker B; other site 1045856001994 D-loop; other site 1045856001995 H-loop/switch region; other site 1045856001996 ABC transporter; Region: ABC_tran_2; pfam12848 1045856001997 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1045856001998 lytic murein transglycosylase; Provisional; Region: PRK11619 1045856001999 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1045856002000 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1045856002001 catalytic residue [active] 1045856002002 Trp operon repressor; Provisional; Region: PRK01381 1045856002003 inosine/xanthosine triphosphatase; Reviewed; Region: PRK05074 1045856002004 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1045856002005 catalytic core [active] 1045856002006 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 1045856002007 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1045856002008 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 1045856002009 hypothetical protein; Provisional; Region: PRK10756 1045856002010 CreA protein; Region: CreA; pfam05981 1045856002011 DNA-binding response regulator CreB; Provisional; Region: PRK11083 1045856002012 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1045856002013 active site 1045856002014 phosphorylation site [posttranslational modification] 1045856002015 intermolecular recognition site; other site 1045856002016 dimerization interface [polypeptide binding]; other site 1045856002017 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1045856002018 DNA binding site [nucleotide binding] 1045856002019 sensory histidine kinase CreC; Provisional; Region: PRK11100 1045856002020 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1045856002021 dimerization interface [polypeptide binding]; other site 1045856002022 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1045856002023 dimer interface [polypeptide binding]; other site 1045856002024 phosphorylation site [posttranslational modification] 1045856002025 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1045856002026 ATP binding site [chemical binding]; other site 1045856002027 Mg2+ binding site [ion binding]; other site 1045856002028 G-X-G motif; other site 1045856002029 Inner membrane protein CreD; Region: CreD; cl01844 1045856002030 two-component response regulator; Provisional; Region: PRK11173 1045856002031 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1045856002032 active site 1045856002033 phosphorylation site [posttranslational modification] 1045856002034 intermolecular recognition site; other site 1045856002035 dimerization interface [polypeptide binding]; other site 1045856002036 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1045856002037 DNA binding site [nucleotide binding] 1045856002038 putative RNA methyltransferase; Provisional; Region: PRK10433 1045856002039 RNA methyltransferase, TrmH family, group 1; Region: rRNA_methyl_1; TIGR00050 1045856002040 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 1045856002041 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 1045856002042 putative catalytic residues [active] 1045856002043 putative nucleotide binding site [chemical binding]; other site 1045856002044 putative aspartate binding site [chemical binding]; other site 1045856002045 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 1045856002046 dimer interface [polypeptide binding]; other site 1045856002047 putative threonine allosteric regulatory site; other site 1045856002048 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922 1045856002049 putative threonine allosteric regulatory site; other site 1045856002050 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1045856002051 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1045856002052 homoserine kinase; Provisional; Region: PRK01212 1045856002053 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1045856002054 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1045856002055 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 1045856002056 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 1045856002057 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1045856002058 catalytic residue [active] 1045856002059 Protein of unknown function (DUF2502); Region: DUF2502; pfam10697 1045856002060 hypothetical protein; Validated; Region: PRK02101 1045856002061 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1045856002062 Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235 1045856002063 transaldolase-like protein; Provisional; Region: PTZ00411 1045856002064 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 1045856002065 active site 1045856002066 dimer interface [polypeptide binding]; other site 1045856002067 catalytic residue [active] 1045856002068 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1045856002069 MPT binding site; other site 1045856002070 trimer interface [polypeptide binding]; other site 1045856002071 metabolite-proton symporter; Region: 2A0106; TIGR00883 1045856002072 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1045856002073 putative substrate translocation pore; other site 1045856002074 hypothetical protein; Provisional; Region: PRK10659 1045856002075 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1045856002076 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1045856002077 nucleotide binding site [chemical binding]; other site 1045856002078 chaperone protein DnaJ; Provisional; Region: PRK10767 1045856002079 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1045856002080 HSP70 interaction site [polypeptide binding]; other site 1045856002081 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 1045856002082 substrate binding site [polypeptide binding]; other site 1045856002083 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1045856002084 Zn binding sites [ion binding]; other site 1045856002085 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1045856002086 dimer interface [polypeptide binding]; other site 1045856002087 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09561 1045856002088 transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062 1045856002089 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1045856002090 The C-terminal substrate binding domain of LysR-type transcriptional activator of the nhaA gene, encoding Na+/H+ antiporter, contains the type 2 periplasmic binding fold; Region: PBP2_NhaR; cd08429 1045856002091 putative dimerization interface [polypeptide binding]; other site 1045856002092 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 1045856002093 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 1045856002094 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1045856002095 active site 1045856002096 Riboflavin kinase; Region: Flavokinase; smart00904 1045856002097 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 1045856002098 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1045856002099 active site 1045856002100 HIGH motif; other site 1045856002101 nucleotide binding site [chemical binding]; other site 1045856002102 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1045856002103 active site 1045856002104 KMSKS motif; other site 1045856002105 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 1045856002106 tRNA binding surface [nucleotide binding]; other site 1045856002107 anticodon binding site; other site 1045856002108 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1045856002109 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 1045856002110 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 1045856002111 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1045856002112 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 1045856002113 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 1045856002114 glucose-6-phosphate isomerase; Provisional; Region: PRK04190 1045856002115 Glucose-6-phosphate isomerase (GPI); Region: GPI; pfam06560 1045856002116 Glucose-6-phosphate isomerase (GPI); Region: GPI; pfam06560 1045856002117 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 1045856002118 PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609 1045856002119 PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830 1045856002120 active site 1045856002121 phosphorylation site [posttranslational modification] 1045856002122 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 1045856002123 active pocket/dimerization site; other site 1045856002124 active site 1045856002125 phosphorylation site [posttranslational modification] 1045856002126 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 1045856002127 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 1045856002128 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1045856002129 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1045856002130 DNA binding site [nucleotide binding] 1045856002131 domain linker motif; other site 1045856002132 Ligand-binding domain of MalI, a transcription regulator of the maltose system of Escherichia coli and its close homologs from other bacteria; Region: PBP1_MalI_like; cd06289 1045856002133 putative ligand binding site [chemical binding]; other site 1045856002134 putative dimerization interface [polypeptide binding]; other site 1045856002135 dihydrodipicolinate reductase; Provisional; Region: PRK00048 1045856002136 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1045856002137 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 1045856002138 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1045856002139 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 1045856002140 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1045856002141 catalytic site [active] 1045856002142 subunit interface [polypeptide binding]; other site 1045856002143 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1045856002144 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1045856002145 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1045856002146 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1045856002147 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1045856002148 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1045856002149 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 1045856002150 IMP binding site; other site 1045856002151 dimer interface [polypeptide binding]; other site 1045856002152 interdomain contacts; other site 1045856002153 partial ornithine binding site; other site 1045856002154 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 1045856002155 glutathione-regulated potassium-efflux system ancillary protein KefF; Provisional; Region: PRK00871 1045856002156 glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562 1045856002157 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 1045856002158 TrkA-N domain; Region: TrkA_N; pfam02254 1045856002159 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1045856002160 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1045856002161 folate binding site [chemical binding]; other site 1045856002162 NADP+ binding site [chemical binding]; other site 1045856002163 bis(5'-nucleosyl)-tetraphosphatase (symmetrical); Region: apaH; TIGR00668 1045856002164 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 1045856002165 active site 1045856002166 metal binding site [ion binding]; metal-binding site 1045856002167 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 1045856002168 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 1045856002169 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 1045856002170 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 1045856002171 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 1045856002172 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 1045856002173 SurA N-terminal domain; Region: SurA_N; pfam09312 1045856002174 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1045856002175 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1045856002176 LPS assembly outer membrane complex protein LptD; Provisional; Region: PRK03761 1045856002177 OstA-like protein; Region: OstA; pfam03968 1045856002178 Organic solvent tolerance protein; Region: OstA_C; pfam04453 1045856002179 Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430 1045856002180 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 1045856002181 putative metal binding site [ion binding]; other site 1045856002182 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1045856002183 HSP70 interaction site [polypeptide binding]; other site 1045856002184 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1045856002185 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1045856002186 active site 1045856002187 ATP-dependent helicase HepA; Validated; Region: PRK04914 1045856002188 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1045856002189 ATP binding site [chemical binding]; other site 1045856002190 putative Mg++ binding site [ion binding]; other site 1045856002191 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1045856002192 nucleotide binding region [chemical binding]; other site 1045856002193 ATP-binding site [chemical binding]; other site 1045856002194 DNA polymerase II; Reviewed; Region: PRK05762 1045856002195 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase II and similar bacterial family-B DNA polymerases; Region: DNA_polB_II_exo; cd05784 1045856002196 active site 1045856002197 catalytic site [active] 1045856002198 substrate binding site [chemical binding]; other site 1045856002199 DNA polymerase type-II subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II; cd05537 1045856002200 active site 1045856002201 metal-binding site 1045856002202 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 1045856002203 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 1045856002204 intersubunit interface [polypeptide binding]; other site 1045856002205 active site 1045856002206 Zn2+ binding site [ion binding]; other site 1045856002207 L-arabinose isomerase; Provisional; Region: PRK02929 1045856002208 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 1045856002209 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 1045856002210 trimer interface [polypeptide binding]; other site 1045856002211 putative substrate binding site [chemical binding]; other site 1045856002212 putative metal binding site [ion binding]; other site 1045856002213 ribulokinase; Provisional; Region: PRK04123 1045856002214 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 1045856002215 N- and C-terminal domain interface [polypeptide binding]; other site 1045856002216 active site 1045856002217 MgATP binding site [chemical binding]; other site 1045856002218 catalytic site [active] 1045856002219 metal binding site [ion binding]; metal-binding site 1045856002220 carbohydrate binding site [chemical binding]; other site 1045856002221 homodimer interface [polypeptide binding]; other site 1045856002222 DNA-binding transcriptional regulator AraC; Provisional; Region: PRK10572 1045856002223 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1045856002224 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1045856002225 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1045856002226 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1045856002227 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1045856002228 thiamine transporter ATP-binding subunit; Provisional; Region: thiQ; PRK10771 1045856002229 ATP-binding cassette domain of the thiamine transport system; Region: ABC_ThiQ_thiamine_transporter; cd03298 1045856002230 Walker A/P-loop; other site 1045856002231 ATP binding site [chemical binding]; other site 1045856002232 Q-loop/lid; other site 1045856002233 ABC transporter signature motif; other site 1045856002234 Walker B; other site 1045856002235 D-loop; other site 1045856002236 H-loop/switch region; other site 1045856002237 thiamine transporter membrane protein; Reviewed; Region: thiP; PRK09433 1045856002238 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1045856002239 dimer interface [polypeptide binding]; other site 1045856002240 conserved gate region; other site 1045856002241 putative PBP binding loops; other site 1045856002242 ABC-ATPase subunit interface; other site 1045856002243 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1045856002244 dimer interface [polypeptide binding]; other site 1045856002245 conserved gate region; other site 1045856002246 putative PBP binding loops; other site 1045856002247 ABC-ATPase subunit interface; other site 1045856002248 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 1045856002249 thiamine transporter substrate binding subunit; Provisional; Region: tbpA; PRK11205 1045856002250 transcriptional regulator SgrR; Provisional; Region: PRK13626 1045856002251 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 1045856002252 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 1045856002253 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1045856002254 sugar efflux transporter; Region: 2A0120; TIGR00899 1045856002255 putative substrate translocation pore; other site 1045856002256 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 1045856002257 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 1045856002258 substrate binding site [chemical binding]; other site 1045856002259 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 1045856002260 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 1045856002261 substrate binding site [chemical binding]; other site 1045856002262 ligand binding site [chemical binding]; other site 1045856002263 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 1045856002264 tartrate dehydrogenase; Region: TTC; TIGR02089 1045856002265 2-isopropylmalate synthase; Validated; Region: PRK00915 1045856002266 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 1045856002267 active site 1045856002268 catalytic residues [active] 1045856002269 metal binding site [ion binding]; metal-binding site 1045856002270 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 1045856002271 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 1045856002272 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1045856002273 The C-terminal substrate binding domain of LysR-type transcriptional regulator LeuO, an activator of leucine synthesis operon, contains the type 2 periplasmic binding fold; Region: PBP2_LeuO; cd08466 1045856002274 putative substrate binding pocket [chemical binding]; other site 1045856002275 putative dimerization interface [polypeptide binding]; other site 1045856002276 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK07979 1045856002277 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1045856002278 PYR/PP interface [polypeptide binding]; other site 1045856002279 dimer interface [polypeptide binding]; other site 1045856002280 TPP binding site [chemical binding]; other site 1045856002281 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1045856002282 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1045856002283 TPP-binding site [chemical binding]; other site 1045856002284 dimer interface [polypeptide binding]; other site 1045856002285 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 1045856002286 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 1045856002287 putative valine binding site [chemical binding]; other site 1045856002288 dimer interface [polypeptide binding]; other site 1045856002289 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 1045856002290 DNA-binding transcriptional regulator FruR; Provisional; Region: PRK11303 1045856002291 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1045856002292 DNA binding site [nucleotide binding] 1045856002293 domain linker motif; other site 1045856002294 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 1045856002295 dimerization interface [polypeptide binding]; other site 1045856002296 ligand binding site [chemical binding]; other site 1045856002297 mraZ protein; Region: TIGR00242 1045856002298 MraZ protein; Region: MraZ; pfam02381 1045856002299 MraZ protein; Region: MraZ; pfam02381 1045856002300 16S rRNA (cytosine(1402)-N(4))-methyltransferase; Region: TIGR00006 1045856002301 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 1045856002302 cell division protein FtsL; Provisional; Region: PRK10772 1045856002303 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 1045856002304 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1045856002305 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1045856002306 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 1045856002307 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1045856002308 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1045856002309 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1045856002310 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed; Region: murF; PRK10773 1045856002311 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1045856002312 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1045856002313 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1045856002314 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 1045856002315 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1045856002316 Mg++ binding site [ion binding]; other site 1045856002317 putative catalytic motif [active] 1045856002318 putative substrate binding site [chemical binding]; other site 1045856002319 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03806 1045856002320 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1045856002321 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1045856002322 cell division protein FtsW; Provisional; Region: PRK10774 1045856002323 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 1045856002324 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1045856002325 active site 1045856002326 homodimer interface [polypeptide binding]; other site 1045856002327 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1045856002328 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1045856002329 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1045856002330 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1045856002331 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 1045856002332 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1045856002333 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 1045856002334 cell division protein FtsQ; Provisional; Region: PRK10775 1045856002335 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 1045856002336 Cell division protein FtsQ; Region: FtsQ; pfam03799 1045856002337 cell division protein FtsA; Reviewed; Region: ftsA; PRK09472 1045856002338 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1045856002339 Cell division protein FtsA; Region: FtsA; pfam14450 1045856002340 cell division protein FtsZ; Validated; Region: PRK09330 1045856002341 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1045856002342 nucleotide binding site [chemical binding]; other site 1045856002343 SulA interaction site; other site 1045856002344 cell division protein FtsZ, alphaProteobacterial C-terminal extension; Region: FtsZ_alphas_C; TIGR03483 1045856002345 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 1045856002346 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 1045856002347 SecA regulator SecM; Provisional; Region: PRK02943 1045856002348 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 1045856002349 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 1045856002350 SEC-C motif; Region: SEC-C; pfam02810 1045856002351 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 1045856002352 active site 1045856002353 8-oxo-dGMP binding site [chemical binding]; other site 1045856002354 nudix motif; other site 1045856002355 metal binding site [ion binding]; metal-binding site 1045856002356 DNA gyrase inhibitor; Reviewed; Region: PRK00418 1045856002357 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4582 1045856002358 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 1045856002359 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1045856002360 CoA-binding site [chemical binding]; other site 1045856002361 ATP-binding [chemical binding]; other site 1045856002362 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05096 1045856002363 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1045856002364 active site 1045856002365 type IV pilin biogenesis protein; Provisional; Region: PRK10573 1045856002366 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1045856002367 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1045856002368 hypothetical protein; Provisional; Region: PRK10436 1045856002369 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 1045856002370 Walker A motif; other site 1045856002371 ATP binding site [chemical binding]; other site 1045856002372 Walker B motif; other site 1045856002373 putative major pilin subunit; Provisional; Region: PRK10574 1045856002374 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 1045856002375 Pilin (bacterial filament); Region: Pilin; pfam00114 1045856002376 quinolinate phosphoribosyltransferase; Validated; Region: PRK09016 1045856002377 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 1045856002378 dimerization interface [polypeptide binding]; other site 1045856002379 active site 1045856002380 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 1045856002381 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1045856002382 amidase catalytic site [active] 1045856002383 Zn binding residues [ion binding]; other site 1045856002384 substrate binding site [chemical binding]; other site 1045856002385 regulatory protein AmpE; Provisional; Region: PRK10987 1045856002386 Glycosyl hydrolase family 43; Region: GH43_1; cd08980 1045856002387 active site 1045856002388 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 1045856002389 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1045856002390 putative substrate translocation pore; other site 1045856002391 aromatic amino acid transporter; Provisional; Region: PRK10238 1045856002392 transcriptional regulator PdhR; Reviewed; Region: pdhR; PRK09464 1045856002393 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1045856002394 DNA-binding site [nucleotide binding]; DNA binding site 1045856002395 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1045856002396 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 1045856002397 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 1045856002398 dimer interface [polypeptide binding]; other site 1045856002399 TPP-binding site [chemical binding]; other site 1045856002400 pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated; Region: aceF; PRK11854 1045856002401 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1045856002402 E3 interaction surface; other site 1045856002403 lipoyl attachment site [posttranslational modification]; other site 1045856002404 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1045856002405 E3 interaction surface; other site 1045856002406 lipoyl attachment site [posttranslational modification]; other site 1045856002407 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1045856002408 E3 interaction surface; other site 1045856002409 lipoyl attachment site [posttranslational modification]; other site 1045856002410 e3 binding domain; Region: E3_binding; pfam02817 1045856002411 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1045856002412 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 1045856002413 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1045856002414 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1045856002415 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1045856002416 Protein of unknown function (DUF2950); Region: DUF2950; pfam11453 1045856002417 Protein of unknown function (DUF3300); Region: DUF3300; pfam11737 1045856002418 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 1045856002419 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 1045856002420 substrate binding site [chemical binding]; other site 1045856002421 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 1045856002422 substrate binding site [chemical binding]; other site 1045856002423 ligand binding site [chemical binding]; other site 1045856002424 hypothetical protein; Provisional; Region: PRK05248 1045856002425 S-adenosylmethionine decarboxylase; Provisional; Region: PRK05462 1045856002426 spermidine synthase; Provisional; Region: PRK00811 1045856002427 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1045856002428 S-adenosylmethionine binding site [chemical binding]; other site 1045856002429 Bacterial chaperone lipoprotein (PulS_OutS); Region: PulS_OutS; cl09898 1045856002430 multicopper oxidase; Provisional; Region: PRK10965 1045856002431 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1045856002432 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1045856002433 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 1045856002434 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 1045856002435 Trp docking motif [polypeptide binding]; other site 1045856002436 putative active site [active] 1045856002437 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1045856002438 active site 1045856002439 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 1045856002440 active site clefts [active] 1045856002441 zinc binding site [ion binding]; other site 1045856002442 dimer interface [polypeptide binding]; other site 1045856002443 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1045856002444 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1045856002445 Walker A/P-loop; other site 1045856002446 ATP binding site [chemical binding]; other site 1045856002447 Q-loop/lid; other site 1045856002448 ABC transporter signature motif; other site 1045856002449 Walker B; other site 1045856002450 D-loop; other site 1045856002451 H-loop/switch region; other site 1045856002452 inner membrane transport permease; Provisional; Region: PRK15066 1045856002453 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1045856002454 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 1045856002455 active pocket/dimerization site; other site 1045856002456 active site 1045856002457 phosphorylation site [posttranslational modification] 1045856002458 Putative catalytic polysaccharide deacetylase domain of uncharacterized protein yadE and similar proteins; Region: CE4_yadE_5s; cd10966 1045856002459 putative active site [active] 1045856002460 putative metal binding site [ion binding]; other site 1045856002461 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 1045856002462 tetramerization interface [polypeptide binding]; other site 1045856002463 active site 1045856002464 pantoate--beta-alanine ligase; Region: panC; TIGR00018 1045856002465 Pantoate-beta-alanine ligase; Region: PanC; cd00560 1045856002466 active site 1045856002467 ATP-binding site [chemical binding]; other site 1045856002468 pantoate-binding site; other site 1045856002469 HXXH motif; other site 1045856002470 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 1045856002471 oligomerization interface [polypeptide binding]; other site 1045856002472 active site 1045856002473 metal binding site [ion binding]; metal-binding site 1045856002474 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 1045856002475 catalytic center binding site [active] 1045856002476 ATP binding site [chemical binding]; other site 1045856002477 poly(A) polymerase I; Provisional; Region: pcnB; PRK11623 1045856002478 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1045856002479 active site 1045856002480 NTP binding site [chemical binding]; other site 1045856002481 metal binding triad [ion binding]; metal-binding site 1045856002482 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1045856002483 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 1045856002484 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 1045856002485 Glutamyl- and glutaminyl-tRNA synthetases [Translation, ribosomal structure and biogenesis]; Region: GlnS; COG0008 1045856002486 active site 1045856002487 HIGH motif; other site 1045856002488 nucleotide binding site [chemical binding]; other site 1045856002489 KMSKS motif; other site 1045856002490 RNA polymerase-binding transcription factor; Provisional; Region: dksA; PRK10778 1045856002491 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 1045856002492 2'-5' RNA ligase; Provisional; Region: PRK15124 1045856002493 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 1045856002494 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 1045856002495 ATP-dependent RNA helicase HrpB; Provisional; Region: PRK11664 1045856002496 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1045856002497 ATP binding site [chemical binding]; other site 1045856002498 putative Mg++ binding site [ion binding]; other site 1045856002499 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1045856002500 nucleotide binding region [chemical binding]; other site 1045856002501 ATP-binding site [chemical binding]; other site 1045856002502 Helicase associated domain (HA2) Add an annotation; Region: HA2; smart00847 1045856002503 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 1045856002504 bifunctional glycosyl transferase/transpeptidase; Reviewed; Region: mrcB; PRK09506 1045856002505 Transglycosylase; Region: Transgly; pfam00912 1045856002506 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1045856002507 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 1045856002508 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1045856002509 N-terminal plug; other site 1045856002510 ligand-binding site [chemical binding]; other site 1045856002511 iron-hydroxamate transporter ATP-binding subunit; Provisional; Region: PRK10575 1045856002512 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1045856002513 Walker A/P-loop; other site 1045856002514 ATP binding site [chemical binding]; other site 1045856002515 Q-loop/lid; other site 1045856002516 ABC transporter signature motif; other site 1045856002517 Walker B; other site 1045856002518 D-loop; other site 1045856002519 H-loop/switch region; other site 1045856002520 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1045856002521 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1045856002522 siderophore binding site; other site 1045856002523 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1045856002524 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1045856002525 ABC-ATPase subunit interface; other site 1045856002526 dimer interface [polypeptide binding]; other site 1045856002527 putative PBP binding regions; other site 1045856002528 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1045856002529 ABC-ATPase subunit interface; other site 1045856002530 dimer interface [polypeptide binding]; other site 1045856002531 putative PBP binding regions; other site 1045856002532 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 1045856002533 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1045856002534 inhibitor-cofactor binding pocket; inhibition site 1045856002535 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1045856002536 catalytic residue [active] 1045856002537 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 1045856002538 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 1045856002539 Cl- selectivity filter; other site 1045856002540 Cl- binding residues [ion binding]; other site 1045856002541 pore gating glutamate residue; other site 1045856002542 dimer interface [polypeptide binding]; other site 1045856002543 H+/Cl- coupling transport residue; other site 1045856002544 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 1045856002545 hypothetical protein; Provisional; Region: PRK10578 1045856002546 UPF0126 domain; Region: UPF0126; pfam03458 1045856002547 UPF0126 domain; Region: UPF0126; pfam03458 1045856002548 vitamin B12-transporter protein BtuF; Provisional; Region: PRK03379 1045856002549 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 1045856002550 cobalamin binding residues [chemical binding]; other site 1045856002551 putative BtuC binding residues; other site 1045856002552 dimer interface [polypeptide binding]; other site 1045856002553 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 1045856002554 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 1045856002555 deoxyguanosinetriphosphate triphosphohydrolase; Provisional; Region: dgt; PRK04926 1045856002556 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1045856002557 Zn2+ binding site [ion binding]; other site 1045856002558 Mg2+ binding site [ion binding]; other site 1045856002559 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 1045856002560 serine endoprotease; Provisional; Region: PRK10942 1045856002561 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1045856002562 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1045856002563 protein binding site [polypeptide binding]; other site 1045856002564 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1045856002565 carbohydrate diacid transcriptional activator CdaR; Provisional; Region: PRK11477 1045856002566 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 1045856002567 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1045856002568 hypothetical protein; Provisional; Region: PRK13677 1045856002569 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 1045856002570 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 1045856002571 trimer interface [polypeptide binding]; other site 1045856002572 active site 1045856002573 substrate binding site [chemical binding]; other site 1045856002574 CoA binding site [chemical binding]; other site 1045856002575 PII uridylyl-transferase; Provisional; Region: PRK05007 1045856002576 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1045856002577 metal binding triad; other site 1045856002578 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1045856002579 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1045856002580 Zn2+ binding site [ion binding]; other site 1045856002581 Mg2+ binding site [ion binding]; other site 1045856002582 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 1045856002583 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 1045856002584 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1045856002585 active site 1045856002586 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1045856002587 rRNA interaction site [nucleotide binding]; other site 1045856002588 S8 interaction site; other site 1045856002589 putative laminin-1 binding site; other site 1045856002590 elongation factor Ts; Provisional; Region: tsf; PRK09377 1045856002591 UBA/TS-N domain; Region: UBA; pfam00627 1045856002592 Elongation factor TS; Region: EF_TS; pfam00889 1045856002593 Elongation factor TS; Region: EF_TS; pfam00889 1045856002594 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1045856002595 putative nucleotide binding site [chemical binding]; other site 1045856002596 uridine monophosphate binding site [chemical binding]; other site 1045856002597 homohexameric interface [polypeptide binding]; other site 1045856002598 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1045856002599 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 1045856002600 hinge region; other site 1045856002601 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 1045856002602 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 1045856002603 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 1045856002604 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 1045856002605 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 1045856002606 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 1045856002607 catalytic residue [active] 1045856002608 putative FPP diphosphate binding site; other site 1045856002609 putative FPP binding hydrophobic cleft; other site 1045856002610 dimer interface [polypeptide binding]; other site 1045856002611 putative IPP diphosphate binding site; other site 1045856002612 CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624 1045856002613 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1045856002614 zinc metallopeptidase RseP; Provisional; Region: PRK10779 1045856002615 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1045856002616 active site 1045856002617 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1045856002618 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1045856002619 protein binding site [polypeptide binding]; other site 1045856002620 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1045856002621 putative substrate binding region [chemical binding]; other site 1045856002622 outer membrane protein assembly factor YaeT; Provisional; Region: PRK11067 1045856002623 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1045856002624 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1045856002625 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1045856002626 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1045856002627 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1045856002628 Surface antigen; Region: Bac_surface_Ag; pfam01103 1045856002629 periplasmic chaperone; Provisional; Region: PRK10780 1045856002630 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 1045856002631 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 1045856002632 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 1045856002633 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 1045856002634 trimer interface [polypeptide binding]; other site 1045856002635 active site 1045856002636 UDP-GlcNAc binding site [chemical binding]; other site 1045856002637 lipid binding site [chemical binding]; lipid-binding site 1045856002638 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 1045856002639 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 1045856002640 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 1045856002641 active site 1045856002642 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 1045856002643 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 1045856002644 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1045856002645 RNA/DNA hybrid binding site [nucleotide binding]; other site 1045856002646 active site 1045856002647 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 1045856002648 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 1045856002649 putative active site [active] 1045856002650 putative PHP Thumb interface [polypeptide binding]; other site 1045856002651 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1045856002652 generic binding surface II; other site 1045856002653 generic binding surface I; other site 1045856002654 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 1045856002655 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 1045856002656 lysine decarboxylase LdcC; Provisional; Region: PRK15399 1045856002657 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 1045856002658 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 1045856002659 homodimer interface [polypeptide binding]; other site 1045856002660 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1045856002661 catalytic residue [active] 1045856002662 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1045856002663 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 1045856002664 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1045856002665 putative metal binding site [ion binding]; other site 1045856002666 tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660 1045856002667 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1045856002668 Ligand Binding Site [chemical binding]; other site 1045856002669 TilS substrate binding domain; Region: TilS; pfam09179 1045856002670 TilS substrate C-terminal domain; Region: TilS_C; pfam11734 1045856002671 Rho-binding antiterminator; Provisional; Region: PRK11625 1045856002672 hypothetical protein; Provisional; Region: PRK04964 1045856002673 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4681 1045856002674 hypothetical protein; Provisional; Region: PRK09256 1045856002675 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 1045856002676 lipoprotein involved with copper homeostasis and adhesion; Provisional; Region: PRK10523 1045856002677 NlpE N-terminal domain; Region: NlpE; pfam04170 1045856002678 prolyl-tRNA synthetase; Provisional; Region: PRK09194 1045856002679 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 1045856002680 dimer interface [polypeptide binding]; other site 1045856002681 motif 1; other site 1045856002682 active site 1045856002683 motif 2; other site 1045856002684 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 1045856002685 putative deacylase active site [active] 1045856002686 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1045856002687 active site 1045856002688 motif 3; other site 1045856002689 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 1045856002690 anticodon binding site; other site 1045856002691 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 1045856002692 homodimer interaction site [polypeptide binding]; other site 1045856002693 cofactor binding site; other site 1045856002694 outer membrane lipoprotein; Reviewed; Region: rcsF; PRK10781 1045856002695 DL-methionine transporter substrate-binding subunit; Provisional; Region: metQ; PRK11063 1045856002696 lipoprotein, YaeC family; Region: TIGR00363 1045856002697 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1045856002698 dimer interface [polypeptide binding]; other site 1045856002699 conserved gate region; other site 1045856002700 ABC-ATPase subunit interface; other site 1045856002701 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 1045856002702 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1045856002703 Walker A/P-loop; other site 1045856002704 ATP binding site [chemical binding]; other site 1045856002705 Q-loop/lid; other site 1045856002706 ABC transporter signature motif; other site 1045856002707 Walker B; other site 1045856002708 D-loop; other site 1045856002709 H-loop/switch region; other site 1045856002710 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 1045856002711 D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942 1045856002712 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1045856002713 active site 1045856002714 motif I; other site 1045856002715 motif II; other site 1045856002716 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1045856002717 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1045856002718 active site 1045856002719 catalytic tetrad [active] 1045856002720 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1045856002721 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1045856002722 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA; cd08478 1045856002723 putative effector binding pocket; other site 1045856002724 dimerization interface [polypeptide binding]; other site 1045856002725 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1045856002726 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1045856002727 putative substrate translocation pore; other site 1045856002728 hypothetical protein; Provisional; Region: PRK05421 1045856002729 putative catalytic site [active] 1045856002730 putative metal binding site [ion binding]; other site 1045856002731 putative phosphate binding site [ion binding]; other site 1045856002732 putative catalytic site [active] 1045856002733 putative phosphate binding site [ion binding]; other site 1045856002734 putative metal binding site [ion binding]; other site 1045856002735 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1045856002736 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1045856002737 S-adenosylmethionine binding site [chemical binding]; other site 1045856002738 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 1045856002739 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1045856002740 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1045856002741 catalytic residue [active] 1045856002742 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1045856002743 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1045856002744 hydroxyacylglutathione hydrolase; Provisional; Region: PRK10241 1045856002745 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1045856002746 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 1045856002747 RNA/DNA hybrid binding site [nucleotide binding]; other site 1045856002748 active site 1045856002749 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 1045856002750 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 1045856002751 active site 1045856002752 catalytic site [active] 1045856002753 substrate binding site [chemical binding]; other site 1045856002754 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1045856002755 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1045856002756 DNA-binding site [nucleotide binding]; DNA binding site 1045856002757 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1045856002758 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1045856002759 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1045856002760 Walker A/P-loop; other site 1045856002761 ATP binding site [chemical binding]; other site 1045856002762 Q-loop/lid; other site 1045856002763 ABC transporter signature motif; other site 1045856002764 Walker B; other site 1045856002765 D-loop; other site 1045856002766 H-loop/switch region; other site 1045856002767 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1045856002768 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 1045856002769 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1045856002770 Walker A/P-loop; other site 1045856002771 ATP binding site [chemical binding]; other site 1045856002772 Q-loop/lid; other site 1045856002773 ABC transporter signature motif; other site 1045856002774 Walker B; other site 1045856002775 D-loop; other site 1045856002776 H-loop/switch region; other site 1045856002777 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1045856002778 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1045856002779 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_5; cd08511 1045856002780 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1045856002781 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1045856002782 dimer interface [polypeptide binding]; other site 1045856002783 conserved gate region; other site 1045856002784 putative PBP binding loops; other site 1045856002785 ABC-ATPase subunit interface; other site 1045856002786 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 1045856002787 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1045856002788 dimer interface [polypeptide binding]; other site 1045856002789 conserved gate region; other site 1045856002790 putative PBP binding loops; other site 1045856002791 ABC-ATPase subunit interface; other site 1045856002792 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 1045856002793 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 1045856002794 C-N hydrolase family amidase; Provisional; Region: PRK10438 1045856002795 Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575 1045856002796 putative active site [active] 1045856002797 catalytic triad [active] 1045856002798 dimer interface [polypeptide binding]; other site 1045856002799 multimer interface [polypeptide binding]; other site 1045856002800 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 1045856002801 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1045856002802 active site 1045856002803 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 1045856002804 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 1045856002805 dimer interface [polypeptide binding]; other site 1045856002806 active site 1045856002807 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 1045856002808 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 1045856002809 putative active site [active] 1045856002810 putative dimer interface [polypeptide binding]; other site 1045856002811 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 1045856002812 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1045856002813 Na(+)-translocating NADH-quinone reductase subunit A; Provisional; Region: PRK05352 1045856002814 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1045856002815 E3 interaction surface; other site 1045856002816 lipoyl attachment site [posttranslational modification]; other site 1045856002817 NQRA C-terminal domain; Region: NQRA_SLBB; pfam11973 1045856002818 Na(+)-translocating NADH-quinone reductase subunit B; Provisional; Region: PRK05349 1045856002819 Na(+)-translocating NADH-quinone reductase subunit C; Provisional; Region: PRK05346 1045856002820 NADH:ubiquinone oxidoreductase, Na(+)-translocating, C subunit; Region: nqrC; TIGR01938 1045856002821 Na(+)-translocating NADH-quinone reductase subunit D; Validated; Region: PRK09292 1045856002822 Na(+)-translocating NADH-quinone reductase subunit E; Provisional; Region: PRK02830 1045856002823 Na(+)-translocating NADH-quinone reductase subunit F; Provisional; Region: PRK05464 1045856002824 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1045856002825 catalytic loop [active] 1045856002826 iron binding site [ion binding]; other site 1045856002827 Na+-translocating NADH:quinone oxidoreductase (Na+-NQR) FAD/NADH binding domain. (Na+-NQR) provides a means of storing redox reaction energy via the transmembrane translocation of Na2+ ions. The C-terminal domain resembles ferredoxin:NADP+ oxidoreductase; Region: NADH_quinone_reductase; cd06188 1045856002828 FAD binding pocket [chemical binding]; other site 1045856002829 FAD binding motif [chemical binding]; other site 1045856002830 phosphate binding motif [ion binding]; other site 1045856002831 beta-alpha-beta structure motif; other site 1045856002832 NAD binding pocket [chemical binding]; other site 1045856002833 Protein of unknown function (DUF539); Region: DUF539; cl01129 1045856002834 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1045856002835 active site 1045856002836 DNA polymerase IV; Validated; Region: PRK02406 1045856002837 DNA binding site [nucleotide binding] 1045856002838 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 1045856002839 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 1045856002840 metal binding site [ion binding]; metal-binding site 1045856002841 dimer interface [polypeptide binding]; other site 1045856002842 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1045856002843 active site 1045856002844 fermentation/respiration switch protein; Reviewed; Region: frsA; PRK05077 1045856002845 DNA-binding transcriptional regulator Crl; Provisional; Region: PRK10984 1045856002846 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1045856002847 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 1045856002848 trimer interface [polypeptide binding]; other site 1045856002849 eyelet of channel; other site 1045856002850 gamma-glutamyl kinase; Provisional; Region: PRK05429 1045856002851 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 1045856002852 nucleotide binding site [chemical binding]; other site 1045856002853 homotetrameric interface [polypeptide binding]; other site 1045856002854 putative phosphate binding site [ion binding]; other site 1045856002855 putative allosteric binding site; other site 1045856002856 PUA domain; Region: PUA; pfam01472 1045856002857 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 1045856002858 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 1045856002859 putative catalytic cysteine [active] 1045856002860 integrase; Provisional; Region: PRK09692 1045856002861 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 1045856002862 active site 1045856002863 Int/Topo IB signature motif; other site 1045856002864 RT_Bac_retron_I: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_I; cd01646 1045856002865 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 1045856002866 putative active site [active] 1045856002867 putative NTP binding site [chemical binding]; other site 1045856002868 putative nucleic acid binding site [nucleotide binding]; other site 1045856002869 RT_Bac_retron_I: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_I; cd01646 1045856002870 putative active site [active] 1045856002871 putative NTP binding site [chemical binding]; other site 1045856002872 putative nucleic acid binding site [nucleotide binding]; other site 1045856002873 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1045856002874 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1045856002875 von Willebrand factor type A domain; Region: VWA_2; pfam13519 1045856002876 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 1045856002877 PA-IL-like protein; Region: PA-IL; pfam07828 1045856002878 PA-IL-like protein; Region: PA-IL; pfam07828 1045856002879 PA-IL-like protein; Region: PA-IL; pfam07828 1045856002880 Major royal jelly protein; Region: MRJP; pfam03022 1045856002881 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1045856002882 classical (c) SDRs; Region: SDR_c; cd05233 1045856002883 NAD(P) binding site [chemical binding]; other site 1045856002884 active site 1045856002885 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1045856002886 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1045856002887 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1045856002888 putative effector binding pocket; other site 1045856002889 dimerization interface [polypeptide binding]; other site 1045856002890 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1045856002891 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1045856002892 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1045856002893 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1045856002894 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1045856002895 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1045856002896 ligand binding site [chemical binding]; other site 1045856002897 flexible hinge region; other site 1045856002898 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 1045856002899 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 1045856002900 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1045856002901 DNA binding site [nucleotide binding] 1045856002902 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1045856002903 Zn2+ binding site [ion binding]; other site 1045856002904 Mg2+ binding site [ion binding]; other site 1045856002905 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1045856002906 Zn2+ binding site [ion binding]; other site 1045856002907 Mg2+ binding site [ion binding]; other site 1045856002908 Fimbrial protein; Region: Fimbrial; pfam00419 1045856002909 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 1045856002910 PapC N-terminal domain; Region: PapC_N; pfam13954 1045856002911 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1045856002912 PapC C-terminal domain; Region: PapC_C; pfam13953 1045856002913 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 1045856002914 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1045856002915 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1045856002916 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1045856002917 GAF domain; Region: GAF_3; pfam13492 1045856002918 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1045856002919 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1045856002920 metal binding site [ion binding]; metal-binding site 1045856002921 active site 1045856002922 I-site; other site 1045856002923 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1045856002924 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1045856002925 S-methylmethionine transporter; Provisional; Region: PRK11387 1045856002926 homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485 1045856002927 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 1045856002928 ABC-type taurine transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: TauA; COG4521 1045856002929 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1045856002930 substrate binding pocket [chemical binding]; other site 1045856002931 membrane-bound complex binding site; other site 1045856002932 hinge residues; other site 1045856002933 taurine transporter ATP-binding subunit; Provisional; Region: tauB; PRK11248 1045856002934 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1045856002935 Walker A/P-loop; other site 1045856002936 ATP binding site [chemical binding]; other site 1045856002937 Q-loop/lid; other site 1045856002938 ABC transporter signature motif; other site 1045856002939 Walker B; other site 1045856002940 D-loop; other site 1045856002941 H-loop/switch region; other site 1045856002942 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1045856002943 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1045856002944 dimer interface [polypeptide binding]; other site 1045856002945 conserved gate region; other site 1045856002946 putative PBP binding loops; other site 1045856002947 ABC-ATPase subunit interface; other site 1045856002948 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 1045856002949 taurine dioxygenase; Reviewed; Region: tauD; PRK09553 1045856002950 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ACT14924; Region: LPLAT_ACT14924-like; cd07986 1045856002951 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1045856002952 putative acyl-acceptor binding pocket; other site 1045856002953 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444 1045856002954 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 1045856002955 dimer interface [polypeptide binding]; other site 1045856002956 active site 1045856002957 Schiff base residues; other site 1045856002958 Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta) domain...; Region: PL_Passenger_AT; cd00253 1045856002959 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 1045856002960 Autotransporter beta-domain; Region: Autotransporter; pfam03797 1045856002961 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11832 1045856002962 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1045856002963 ligand binding site [chemical binding]; other site 1045856002964 flexible hinge region; other site 1045856002965 beta-lactam binding protein AmpH; Provisional; Region: PRK10662 1045856002966 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1045856002967 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 1045856002968 Isochorismatase family; Region: Isochorismatase; pfam00857 1045856002969 catalytic triad [active] 1045856002970 conserved cis-peptide bond; other site 1045856002971 microcin B17 transporter; Reviewed; Region: PRK11098 1045856002972 Protein of unknown function (DUF1615); Region: DUF1615; pfam07759 1045856002973 Protein of unknown function (DUF2755); Region: DUF2755; pfam10954 1045856002974 Protein of unknown function (DUF2754); Region: DUF2754; pfam10953 1045856002975 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 1045856002976 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1045856002977 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 1045856002978 Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904 1045856002979 drug efflux system protein MdtG; Provisional; Region: PRK09874 1045856002980 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1045856002981 putative substrate translocation pore; other site 1045856002982 anti-RssB factor; Provisional; Region: PRK10244 1045856002983 alkaline phosphatase; Provisional; Region: PRK10518 1045856002984 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 1045856002985 dimer interface [polypeptide binding]; other site 1045856002986 active site 1045856002987 psiF repeat; Region: PsiF_repeat; pfam07769 1045856002988 psiF repeat; Region: PsiF_repeat; pfam07769 1045856002989 diguanylate cyclase AdrA; Provisional; Region: adrA; PRK10245 1045856002990 MASE2 domain; Region: MASE2; pfam05230 1045856002991 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1045856002992 metal binding site [ion binding]; metal-binding site 1045856002993 active site 1045856002994 I-site; other site 1045856002995 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 1045856002996 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1045856002997 hypothetical protein; Validated; Region: PRK00124 1045856002998 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 1045856002999 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1045856003000 ADP binding site [chemical binding]; other site 1045856003001 magnesium binding site [ion binding]; other site 1045856003002 putative shikimate binding site; other site 1045856003003 hypothetical protein; Provisional; Region: PRK10380 1045856003004 hypothetical protein; Provisional; Region: PRK10481 1045856003005 hypothetical protein; Provisional; Region: PRK10579 1045856003006 recombination associated protein; Reviewed; Region: rdgC; PRK00321 1045856003007 fructokinase; Reviewed; Region: PRK09557 1045856003008 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1045856003009 nucleotide binding site [chemical binding]; other site 1045856003010 exonuclease subunit SbcC; Provisional; Region: PRK10246 1045856003011 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1045856003012 Walker A/P-loop; other site 1045856003013 ATP binding site [chemical binding]; other site 1045856003014 Q-loop/lid; other site 1045856003015 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1045856003016 ABC transporter signature motif; other site 1045856003017 Walker B; other site 1045856003018 D-loop; other site 1045856003019 H-loop/switch region; other site 1045856003020 exonuclease subunit SbcD; Provisional; Region: PRK10966 1045856003021 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1045856003022 active site 1045856003023 metal binding site [ion binding]; metal-binding site 1045856003024 DNA binding site [nucleotide binding] 1045856003025 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 1045856003026 transcriptional regulator PhoB; Provisional; Region: PRK10161 1045856003027 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1045856003028 active site 1045856003029 phosphorylation site [posttranslational modification] 1045856003030 intermolecular recognition site; other site 1045856003031 dimerization interface [polypeptide binding]; other site 1045856003032 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1045856003033 DNA binding site [nucleotide binding] 1045856003034 phosphate regulon sensor protein; Provisional; Region: phoR; PRK11006 1045856003035 Domain of unknown function (DUF3329); Region: DUF3329; pfam11808 1045856003036 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1045856003037 putative active site [active] 1045856003038 heme pocket [chemical binding]; other site 1045856003039 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1045856003040 dimer interface [polypeptide binding]; other site 1045856003041 phosphorylation site [posttranslational modification] 1045856003042 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1045856003043 ATP binding site [chemical binding]; other site 1045856003044 Mg2+ binding site [ion binding]; other site 1045856003045 G-X-G motif; other site 1045856003046 branched-chain amino acid transport system 2 carrier protein BrnQ; Provisional; Region: PRK15433 1045856003047 putative proline-specific permease; Provisional; Region: proY; PRK10580 1045856003048 maltodextrin glucosidase; Provisional; Region: PRK10785 1045856003049 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 1045856003050 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 1045856003051 active site 1045856003052 homodimer interface [polypeptide binding]; other site 1045856003053 catalytic site [active] 1045856003054 Isochorismatase family; Region: Isochorismatase; pfam00857 1045856003055 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 1045856003056 catalytic triad [active] 1045856003057 dimer interface [polypeptide binding]; other site 1045856003058 conserved cis-peptide bond; other site 1045856003059 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224 1045856003060 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 1045856003061 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 1045856003062 active site 1045856003063 peroxidase; Provisional; Region: PRK15000 1045856003064 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1045856003065 dimer interface [polypeptide binding]; other site 1045856003066 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1045856003067 catalytic triad [active] 1045856003068 peroxidatic and resolving cysteines [active] 1045856003069 acyl carrier protein phosphodiesterase; Provisional; Region: PRK10045 1045856003070 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 1045856003071 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 1045856003072 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 1045856003073 tRNA-guanine family transglycosylase; Region: tgt_general; TIGR00449 1045856003074 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 1045856003075 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 1045856003076 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 1045856003077 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 1045856003078 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 1045856003079 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 1045856003080 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 1045856003081 Protein export membrane protein; Region: SecD_SecF; pfam02355 1045856003082 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 1045856003083 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1045856003084 Predicted transcriptional regulator [Transcription]; Region: COG2378 1045856003085 HTH domain; Region: HTH_11; pfam08279 1045856003086 WYL domain; Region: WYL; pfam13280 1045856003087 nucleoside-specific channel-forming protein Tsx; Provisional; Region: PRK15106 1045856003088 hypothetical protein; Provisional; Region: PRK11530 1045856003089 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 1045856003090 ATP cone domain; Region: ATP-cone; pfam03477 1045856003091 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 1045856003092 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 1045856003093 catalytic motif [active] 1045856003094 Zn binding site [ion binding]; other site 1045856003095 riboflavin-specific deaminase C-terminal domain; Region: ribD_Cterm; TIGR00227 1045856003096 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 1045856003097 homopentamer interface [polypeptide binding]; other site 1045856003098 active site 1045856003099 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 1045856003100 putative RNA binding site [nucleotide binding]; other site 1045856003101 thiamine monophosphate kinase; Provisional; Region: PRK05731 1045856003102 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 1045856003103 ATP binding site [chemical binding]; other site 1045856003104 dimerization interface [polypeptide binding]; other site 1045856003105 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1045856003106 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1045856003107 active site 1045856003108 catalytic tetrad [active] 1045856003109 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 1045856003110 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 1045856003111 TPP-binding site; other site 1045856003112 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1045856003113 PYR/PP interface [polypeptide binding]; other site 1045856003114 dimer interface [polypeptide binding]; other site 1045856003115 TPP binding site [chemical binding]; other site 1045856003116 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1045856003117 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1045856003118 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1045856003119 substrate binding pocket [chemical binding]; other site 1045856003120 chain length determination region; other site 1045856003121 substrate-Mg2+ binding site; other site 1045856003122 catalytic residues [active] 1045856003123 aspartate-rich region 1; other site 1045856003124 active site lid residues [active] 1045856003125 aspartate-rich region 2; other site 1045856003126 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 1045856003127 tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269 1045856003128 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 1045856003129 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 1045856003130 Ligand Binding Site [chemical binding]; other site 1045856003131 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1045856003132 active site residue [active] 1045856003133 oxidative-stress-resistance chaperone; Provisional; Region: PRK11574 1045856003134 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 1045856003135 conserved cys residue [active] 1045856003136 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 1045856003137 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1045856003138 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1045856003139 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 1045856003140 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 1045856003141 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1045856003142 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1045856003143 putative substrate translocation pore; other site 1045856003144 protoheme IX farnesyltransferase; Provisional; Region: PRK13362 1045856003145 UbiA prenyltransferase family; Region: UbiA; pfam01040 1045856003146 cytochrome o ubiquinol oxidase subunit IV; Provisional; Region: PRK10582 1045856003147 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 1045856003148 Subunit I/III interface [polypeptide binding]; other site 1045856003149 Subunit III/IV interface [polypeptide binding]; other site 1045856003150 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1045856003151 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1045856003152 D-pathway; other site 1045856003153 Putative ubiquinol binding site [chemical binding]; other site 1045856003154 Low-spin heme (heme b) binding site [chemical binding]; other site 1045856003155 Putative water exit pathway; other site 1045856003156 Binuclear center (heme o3/CuB) [ion binding]; other site 1045856003157 K-pathway; other site 1045856003158 Putative proton exit pathway; other site 1045856003159 cytochrome o ubiquinol oxidase subunit II; Provisional; Region: PRK10525 1045856003160 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1045856003161 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 1045856003162 muropeptide transporter; Reviewed; Region: ampG; PRK11902 1045856003163 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1045856003164 putative substrate translocation pore; other site 1045856003165 hypothetical protein; Provisional; Region: PRK11627 1045856003166 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 1045856003167 Uncharacterized lipoprotein; Region: Lipoprotein_16; pfam03923 1045856003168 transcriptional regulator BolA; Provisional; Region: PRK11628 1045856003169 trigger factor; Provisional; Region: tig; PRK01490 1045856003170 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1045856003171 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1045856003172 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 1045856003173 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1045856003174 oligomer interface [polypeptide binding]; other site 1045856003175 active site residues [active] 1045856003176 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1045856003177 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 1045856003178 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1045856003179 Walker A motif; other site 1045856003180 ATP binding site [chemical binding]; other site 1045856003181 Walker B motif; other site 1045856003182 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1045856003183 DNA-binding ATP-dependent protease La; Provisional; Region: PRK10787 1045856003184 Found in ATP-dependent protease La (LON); Region: LON; smart00464 1045856003185 Found in ATP-dependent protease La (LON); Region: LON; smart00464 1045856003186 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1045856003187 Walker A motif; other site 1045856003188 ATP binding site [chemical binding]; other site 1045856003189 Walker B motif; other site 1045856003190 arginine finger; other site 1045856003191 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1045856003192 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1045856003193 IHF dimer interface [polypeptide binding]; other site 1045856003194 IHF - DNA interface [nucleotide binding]; other site 1045856003195 periplasmic folding chaperone; Provisional; Region: PRK10788 1045856003196 SurA N-terminal domain; Region: SurA_N_3; cl07813 1045856003197 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 1045856003198 competence protein ComEA helix-hairpin-helix repeat region; Region: TIGR00426 1045856003199 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1045856003200 active site 1045856003201 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 1045856003202 Ligand Binding Site [chemical binding]; other site 1045856003203 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 1045856003204 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 1045856003205 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1045856003206 thiamin pyrimidine pyrophosphate hydrolase; Provisional; Region: PRK15126 1045856003207 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1045856003208 active site 1045856003209 motif I; other site 1045856003210 motif II; other site 1045856003211 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1045856003212 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 1045856003213 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1045856003214 catalytic residue [active] 1045856003215 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1045856003216 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1045856003217 putative DNA binding site [nucleotide binding]; other site 1045856003218 putative Zn2+ binding site [ion binding]; other site 1045856003219 AsnC family; Region: AsnC_trans_reg; pfam01037 1045856003220 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 1045856003221 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1045856003222 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1045856003223 Walker A/P-loop; other site 1045856003224 ATP binding site [chemical binding]; other site 1045856003225 Q-loop/lid; other site 1045856003226 ABC transporter signature motif; other site 1045856003227 Walker B; other site 1045856003228 D-loop; other site 1045856003229 H-loop/switch region; other site 1045856003230 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10790 1045856003231 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1045856003232 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1045856003233 Walker A/P-loop; other site 1045856003234 ATP binding site [chemical binding]; other site 1045856003235 Q-loop/lid; other site 1045856003236 ABC transporter signature motif; other site 1045856003237 Walker B; other site 1045856003238 D-loop; other site 1045856003239 H-loop/switch region; other site 1045856003240 nitrogen regulatory protein P-II 2; Provisional; Region: PRK10665 1045856003241 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1045856003242 ammonium transporter; Provisional; Region: PRK10666 1045856003243 acyl-CoA thioesterase II; Provisional; Region: PRK10526 1045856003244 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 1045856003245 active site 1045856003246 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 1045856003247 catalytic triad [active] 1045856003248 dimer interface [polypeptide binding]; other site 1045856003249 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3126 1045856003250 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 1045856003251 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1045856003252 DNA binding site [nucleotide binding] 1045856003253 active site 1045856003254 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1045856003255 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1045856003256 DNA-binding site [nucleotide binding]; DNA binding site 1045856003257 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1045856003258 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1045856003259 homodimer interface [polypeptide binding]; other site 1045856003260 catalytic residue [active] 1045856003261 Predicted membrane protein [Function unknown]; Region: COG2364 1045856003262 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1045856003263 lac repressor; Reviewed; Region: lacI; PRK09526 1045856003264 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1045856003265 DNA binding site [nucleotide binding] 1045856003266 domain linker motif; other site 1045856003267 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 1045856003268 ligand binding site [chemical binding]; other site 1045856003269 dimerization interface (open form) [polypeptide binding]; other site 1045856003270 dimerization interface (closed form) [polypeptide binding]; other site 1045856003271 beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525 1045856003272 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 1045856003273 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 1045856003274 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 1045856003275 Beta galactosidase small chain; Region: Bgal_small_N; pfam02929 1045856003276 nickel/cobalt efflux protein RcnA; Provisional; Region: PRK10019 1045856003277 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 1045856003278 putative metal binding site [ion binding]; other site 1045856003279 putative homodimer interface [polypeptide binding]; other site 1045856003280 putative homotetramer interface [polypeptide binding]; other site 1045856003281 putative homodimer-homodimer interface [polypeptide binding]; other site 1045856003282 putative allosteric switch controlling residues; other site 1045856003283 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 1045856003284 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 1045856003285 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1045856003286 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 1045856003287 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1045856003288 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1045856003289 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1045856003290 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1045856003291 DNA-binding site [nucleotide binding]; DNA binding site 1045856003292 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1045856003293 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1045856003294 homodimer interface [polypeptide binding]; other site 1045856003295 catalytic residue [active] 1045856003296 sigma70 family sigma factor YlaC; Region: YlaC; pfam10777 1045856003297 maltose O-acetyltransferase; Provisional; Region: PRK10092 1045856003298 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 1045856003299 active site 1045856003300 substrate binding site [chemical binding]; other site 1045856003301 trimer interface [polypeptide binding]; other site 1045856003302 CoA binding site [chemical binding]; other site 1045856003303 gene expression modulator; Provisional; Region: PRK10945 1045856003304 Hha toxicity attenuator; Provisional; Region: PRK10667 1045856003305 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 1045856003306 Protein export membrane protein; Region: SecD_SecF; cl14618 1045856003307 Protein export membrane protein; Region: SecD_SecF; cl14618 1045856003308 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 1045856003309 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1045856003310 HlyD family secretion protein; Region: HlyD_3; pfam13437 1045856003311 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 1045856003312 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1045856003313 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 1045856003314 hypothetical protein; Provisional; Region: PRK11281 1045856003315 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 1045856003316 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1045856003317 hypothetical protein; Provisional; Region: PRK11038 1045856003318 primosomal replication protein N''; Provisional; Region: PRK10093 1045856003319 hypothetical protein; Provisional; Region: PRK10527 1045856003320 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1045856003321 active site 1045856003322 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994 1045856003323 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1045856003324 Walker A motif; other site 1045856003325 ATP binding site [chemical binding]; other site 1045856003326 Walker B motif; other site 1045856003327 DNA polymerase III subunit delta'; Validated; Region: PRK08485 1045856003328 arginine finger; other site 1045856003329 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 1045856003330 DNA polymerase III subunits tau domain IV DnaB-binding; Region: DNA_pol3_tau_4; pfam12168 1045856003331 DNA polymerase III tau subunit V interacting with alpha; Region: DNA_pol3_tau_5; pfam12170 1045856003332 hypothetical protein; Validated; Region: PRK00153 1045856003333 recombination protein RecR; Reviewed; Region: recR; PRK00076 1045856003334 RecR protein; Region: RecR; pfam02132 1045856003335 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1045856003336 putative active site [active] 1045856003337 putative metal-binding site [ion binding]; other site 1045856003338 tetramer interface [polypeptide binding]; other site 1045856003339 heat shock protein 90; Provisional; Region: PRK05218 1045856003340 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1045856003341 ATP binding site [chemical binding]; other site 1045856003342 Mg2+ binding site [ion binding]; other site 1045856003343 G-X-G motif; other site 1045856003344 adenylate kinase; Reviewed; Region: adk; PRK00279 1045856003345 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1045856003346 AMP-binding site [chemical binding]; other site 1045856003347 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1045856003348 ferrochelatase; Reviewed; Region: hemH; PRK00035 1045856003349 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 1045856003350 C-terminal domain interface [polypeptide binding]; other site 1045856003351 active site 1045856003352 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 1045856003353 active site 1045856003354 N-terminal domain interface [polypeptide binding]; other site 1045856003355 inosine/guanosine kinase; Provisional; Region: PRK15074 1045856003356 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1045856003357 putative cation:proton antiport protein; Provisional; Region: PRK10669 1045856003358 Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651 1045856003359 TrkA-N domain; Region: TrkA_N; pfam02254 1045856003360 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1045856003361 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1045856003362 putative substrate translocation pore; other site 1045856003363 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1045856003364 bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558 1045856003365 Escherichia coli UshA and related proteins, N-terminal metallophosphatase domain; Region: MPP_UshA_N; cd07405 1045856003366 active site 1045856003367 metal binding site [ion binding]; metal-binding site 1045856003368 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1045856003369 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 1045856003370 putative deacylase active site [active] 1045856003371 TraB family; Region: TraB; cl12050 1045856003372 copper exporting ATPase; Provisional; Region: copA; PRK10671 1045856003373 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1045856003374 metal-binding site [ion binding] 1045856003375 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1045856003376 metal-binding site [ion binding] 1045856003377 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1045856003378 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1045856003379 motif II; other site 1045856003380 DNA-binding transcriptional regulator CueR; Provisional; Region: PRK10227 1045856003381 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 1045856003382 DNA binding residues [nucleotide binding] 1045856003383 dimer interface [polypeptide binding]; other site 1045856003384 copper binding site [ion binding]; other site 1045856003385 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 1045856003386 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1045856003387 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 1045856003388 putative ABC transporter ATP-binding protein YbbL; Provisional; Region: PRK10247 1045856003389 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1045856003390 Walker A/P-loop; other site 1045856003391 ATP binding site [chemical binding]; other site 1045856003392 Q-loop/lid; other site 1045856003393 ABC transporter signature motif; other site 1045856003394 Walker B; other site 1045856003395 D-loop; other site 1045856003396 H-loop/switch region; other site 1045856003397 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 1045856003398 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 1045856003399 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 1045856003400 oxidoreductase; Provisional; Region: PRK08017 1045856003401 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1045856003402 NADP binding site [chemical binding]; other site 1045856003403 active site 1045856003404 steroid binding site; other site 1045856003405 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 1045856003406 active site 1045856003407 catalytic triad [active] 1045856003408 oxyanion hole [active] 1045856003409 switch loop; other site 1045856003410 putative ABC transporter ATP-binding protein YbbA; Provisional; Region: PRK10584 1045856003411 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1045856003412 Walker A/P-loop; other site 1045856003413 ATP binding site [chemical binding]; other site 1045856003414 Q-loop/lid; other site 1045856003415 ABC transporter signature motif; other site 1045856003416 Walker B; other site 1045856003417 D-loop; other site 1045856003418 H-loop/switch region; other site 1045856003419 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 1045856003420 FtsX-like permease family; Region: FtsX; pfam02687 1045856003421 FtsX-like permease family; Region: FtsX; pfam02687 1045856003422 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1045856003423 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1045856003424 tRNA 2-selenouridine synthase; Provisional; Region: PRK11784 1045856003425 Member of the Rhodanese Homology Domain superfamily. This CD includes several putative ATP /GTP binding proteins including E. coli YbbB; Region: RHOD_YbbB; cd01520 1045856003426 active site residue [active] 1045856003427 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 1045856003428 ATP-grasp domain; Region: ATP-grasp; pfam02222 1045856003429 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 1045856003430 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 1045856003431 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1045856003432 putative active site [active] 1045856003433 putative metal binding site [ion binding]; other site 1045856003434 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 1045856003435 substrate binding site [chemical binding]; other site 1045856003436 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1045856003437 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1045856003438 active site 1045856003439 HIGH motif; other site 1045856003440 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1045856003441 KMSKS motif; other site 1045856003442 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 1045856003443 tRNA binding surface [nucleotide binding]; other site 1045856003444 anticodon binding site; other site 1045856003445 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 1045856003446 DNA-binding transcriptional repressor MalI; Provisional; Region: PRK10014 1045856003447 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1045856003448 DNA binding site [nucleotide binding] 1045856003449 domain linker motif; other site 1045856003450 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1045856003451 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 1045856003452 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1045856003453 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1045856003454 active site turn [active] 1045856003455 phosphorylation site [posttranslational modification] 1045856003456 ribosome-associated protein; Provisional; Region: PRK11507 1045856003457 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792 1045856003458 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1045856003459 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1045856003460 homodimer interface [polypeptide binding]; other site 1045856003461 NADP binding site [chemical binding]; other site 1045856003462 substrate binding site [chemical binding]; other site 1045856003463 type-1 fimbrial protein subunit A; Provisional; Region: PRK15194 1045856003464 fimbrial protein FimI; Provisional; Region: PRK15200 1045856003465 fimbrial chaperone protein FimC; Provisional; Region: PRK15195 1045856003466 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1045856003467 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1045856003468 outer membrane usher protein FimD; Provisional; Region: PRK15198 1045856003469 PapC N-terminal domain; Region: PapC_N; pfam13954 1045856003470 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1045856003471 PapC C-terminal domain; Region: PapC_C; pfam13953 1045856003472 Fimbrial protein; Region: Fimbrial; cl01416 1045856003473 Fimbrial protein; Region: Fimbrial; cl01416 1045856003474 transcriptional regulator FimZ; Provisional; Region: PRK09935 1045856003475 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1045856003476 active site 1045856003477 phosphorylation site [posttranslational modification] 1045856003478 intermolecular recognition site; other site 1045856003479 dimerization interface [polypeptide binding]; other site 1045856003480 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1045856003481 DNA binding residues [nucleotide binding] 1045856003482 dimerization interface [polypeptide binding]; other site 1045856003483 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1045856003484 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1045856003485 DNA binding residues [nucleotide binding] 1045856003486 dimerization interface [polypeptide binding]; other site 1045856003487 EAL domain; Region: EAL; pfam00563 1045856003488 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1045856003489 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1045856003490 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 1045856003491 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1045856003492 dimer interface [polypeptide binding]; other site 1045856003493 conserved gate region; other site 1045856003494 ABC-ATPase subunit interface; other site 1045856003495 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1045856003496 dimer interface [polypeptide binding]; other site 1045856003497 conserved gate region; other site 1045856003498 putative PBP binding loops; other site 1045856003499 ABC-ATPase subunit interface; other site 1045856003500 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1045856003501 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 1045856003502 Walker A/P-loop; other site 1045856003503 ATP binding site [chemical binding]; other site 1045856003504 Q-loop/lid; other site 1045856003505 ABC transporter signature motif; other site 1045856003506 Walker B; other site 1045856003507 D-loop; other site 1045856003508 H-loop/switch region; other site 1045856003509 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1045856003510 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1045856003511 N-terminal plug; other site 1045856003512 ligand-binding site [chemical binding]; other site 1045856003513 phenylalanine transporter; Provisional; Region: PRK10249 1045856003514 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1045856003515 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1045856003516 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1045856003517 Metal-binding active site; metal-binding site 1045856003518 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 1045856003519 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1045856003520 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1045856003521 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1045856003522 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1045856003523 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1045856003524 DNA binding site [nucleotide binding] 1045856003525 domain linker motif; other site 1045856003526 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 1045856003527 dimerization interface [polypeptide binding]; other site 1045856003528 ligand binding site [chemical binding]; other site 1045856003529 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1045856003530 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1045856003531 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1045856003532 putative transporter; Provisional; Region: PRK10504 1045856003533 putative substrate translocation pore; other site 1045856003534 Helix-turn-helix domain; Region: HTH_31; pfam13560 1045856003535 sequence-specific DNA binding site [nucleotide binding]; other site 1045856003536 salt bridge; other site 1045856003537 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 1045856003538 dimer interface [polypeptide binding]; other site 1045856003539 FMN binding site [chemical binding]; other site 1045856003540 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1045856003541 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1045856003542 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1045856003543 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 1045856003544 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 1045856003545 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1045856003546 Protein of unknown function (DUF1158); Region: DUF1158; pfam06643 1045856003547 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1045856003548 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 1045856003549 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1045856003550 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1045856003551 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1045856003552 motif II; other site 1045856003553 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1045856003554 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1045856003555 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1045856003556 HlyD family secretion protein; Region: HlyD_3; pfam13437 1045856003557 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1045856003558 gamma-glutamyl:cysteine ligase; Provisional; Region: PRK13516 1045856003559 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 1045856003560 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 1045856003561 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1045856003562 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1045856003563 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1045856003564 Fusaric acid resistance protein family; Region: FUSC; pfam04632 1045856003565 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1045856003566 p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559 1045856003567 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1045856003568 HlyD family secretion protein; Region: HlyD_3; pfam13437 1045856003569 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 1045856003570 BON domain; Region: BON; pfam04972 1045856003571 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1045856003572 Bacterial protein of unknown function (DUF937); Region: DUF937; cl01528 1045856003573 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 1045856003574 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1045856003575 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1045856003576 short chain dehydrogenase; Provisional; Region: PRK06180 1045856003577 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1045856003578 NADP binding site [chemical binding]; other site 1045856003579 active site 1045856003580 steroid binding site; other site 1045856003581 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 1045856003582 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1045856003583 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1045856003584 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1045856003585 HlyD family secretion protein; Region: HlyD_3; pfam13437 1045856003586 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1045856003587 Predicted transcriptional regulator [Transcription]; Region: COG1959 1045856003588 Transcriptional regulator; Region: Rrf2; pfam02082 1045856003589 Transcriptional regulator; Region: Rrf2; cl17282 1045856003590 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1045856003591 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1045856003592 DNA-binding site [nucleotide binding]; DNA binding site 1045856003593 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1045856003594 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1045856003595 homodimer interface [polypeptide binding]; other site 1045856003596 catalytic residue [active] 1045856003597 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 1045856003598 Predicted membrane protein [Function unknown]; Region: COG4541 1045856003599 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 1045856003600 catalytic residues [active] 1045856003601 dimer interface [polypeptide binding]; other site 1045856003602 classical (c) SDRs; Region: SDR_c; cd05233 1045856003603 NAD(P) binding site [chemical binding]; other site 1045856003604 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1045856003605 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1045856003606 Coenzyme A binding pocket [chemical binding]; other site 1045856003607 LysE type translocator; Region: LysE; cl00565 1045856003608 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 1045856003609 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1045856003610 active site 1045856003611 metal binding site [ion binding]; metal-binding site 1045856003612 hexamer interface [polypeptide binding]; other site 1045856003613 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1045856003614 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1045856003615 O-methyltransferase; Region: Methyltransf_2; pfam00891 1045856003616 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1045856003617 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1045856003618 putative substrate translocation pore; other site 1045856003619 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1045856003620 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1045856003621 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1045856003622 putative effector binding pocket; other site 1045856003623 dimerization interface [polypeptide binding]; other site 1045856003624 short chain dehydrogenase; Provisional; Region: PRK06500 1045856003625 classical (c) SDRs; Region: SDR_c; cd05233 1045856003626 NAD(P) binding site [chemical binding]; other site 1045856003627 active site 1045856003628 DinB family; Region: DinB; cl17821 1045856003629 DinB superfamily; Region: DinB_2; pfam12867 1045856003630 short chain dehydrogenase; Provisional; Region: PRK06523 1045856003631 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1045856003632 NAD(P) binding site [chemical binding]; other site 1045856003633 active site 1045856003634 SnoaL-like domain; Region: SnoaL_2; pfam12680 1045856003635 Predicted transcriptional regulators [Transcription]; Region: COG1733 1045856003636 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1045856003637 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 1045856003638 Sulfatase; Region: Sulfatase; pfam00884 1045856003639 Autotransporter beta-domain; Region: Autotransporter; pfam03797 1045856003640 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1045856003641 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1045856003642 active site 1045856003643 phosphorylation site [posttranslational modification] 1045856003644 intermolecular recognition site; other site 1045856003645 dimerization interface [polypeptide binding]; other site 1045856003646 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1045856003647 DNA binding residues [nucleotide binding] 1045856003648 dimerization interface [polypeptide binding]; other site 1045856003649 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1045856003650 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1045856003651 dimer interface [polypeptide binding]; other site 1045856003652 phosphorylation site [posttranslational modification] 1045856003653 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1045856003654 ATP binding site [chemical binding]; other site 1045856003655 Mg2+ binding site [ion binding]; other site 1045856003656 G-X-G motif; other site 1045856003657 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1045856003658 Response regulator receiver domain; Region: Response_reg; pfam00072 1045856003659 active site 1045856003660 phosphorylation site [posttranslational modification] 1045856003661 intermolecular recognition site; other site 1045856003662 dimerization interface [polypeptide binding]; other site 1045856003663 YebG protein; Region: YebG; pfam07130 1045856003664 MltA-interacting protein MipA; Region: MipA; cl01504 1045856003665 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 1045856003666 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1045856003667 active site 1045856003668 phosphorylation site [posttranslational modification] 1045856003669 intermolecular recognition site; other site 1045856003670 dimerization interface [polypeptide binding]; other site 1045856003671 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1045856003672 DNA binding site [nucleotide binding] 1045856003673 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1045856003674 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1045856003675 dimer interface [polypeptide binding]; other site 1045856003676 phosphorylation site [posttranslational modification] 1045856003677 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1045856003678 ATP binding site [chemical binding]; other site 1045856003679 Mg2+ binding site [ion binding]; other site 1045856003680 G-X-G motif; other site 1045856003681 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1045856003682 YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgH_like; cd02198 1045856003683 homotrimer interaction site [polypeptide binding]; other site 1045856003684 putative active site [active] 1045856003685 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1045856003686 putative substrate translocation pore; other site 1045856003687 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 1045856003688 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1045856003689 NAD(P) binding site [chemical binding]; other site 1045856003690 active site 1045856003691 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1045856003692 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1045856003693 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1045856003694 dimerization interface [polypeptide binding]; other site 1045856003695 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1045856003696 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1045856003697 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 1045856003698 putative effector binding pocket; other site 1045856003699 putative dimerization interface [polypeptide binding]; other site 1045856003700 short chain dehydrogenase; Provisional; Region: PRK12937 1045856003701 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 1045856003702 NADP binding site [chemical binding]; other site 1045856003703 homodimer interface [polypeptide binding]; other site 1045856003704 active site 1045856003705 substrate binding site [chemical binding]; other site 1045856003706 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1045856003707 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1045856003708 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1045856003709 dimerization interface [polypeptide binding]; other site 1045856003710 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 1045856003711 Isochorismatase family; Region: Isochorismatase; pfam00857 1045856003712 catalytic triad [active] 1045856003713 dimer interface [polypeptide binding]; other site 1045856003714 conserved cis-peptide bond; other site 1045856003715 Chorismate mutase type II; Region: CM_2; cl00693 1045856003716 Catalase-like heme-binding proteins similar to the uncharacterized srpA; Region: srpA_like; cd08153 1045856003717 putative heme binding pocket [chemical binding]; other site 1045856003718 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 1045856003719 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1045856003720 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1045856003721 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 1045856003722 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1045856003723 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1045856003724 metal binding site [ion binding]; metal-binding site 1045856003725 active site 1045856003726 I-site; other site 1045856003727 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1045856003728 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1045856003729 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1045856003730 Coenzyme A binding pocket [chemical binding]; other site 1045856003731 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1045856003732 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1045856003733 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1045856003734 dimerization interface [polypeptide binding]; other site 1045856003735 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 1045856003736 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg6; cd04781 1045856003737 DNA binding residues [nucleotide binding] 1045856003738 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1045856003739 putative dimer interface [polypeptide binding]; other site 1045856003740 putative metal binding residues [ion binding]; other site 1045856003741 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 1045856003742 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1045856003743 RibD C-terminal domain; Region: RibD_C; cl17279 1045856003744 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1045856003745 Phosphotransferase enzyme family; Region: APH; pfam01636 1045856003746 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1045856003747 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1045856003748 The C-terminal substrate binding domain of LysR-type transcrptional regulator BudR, which is responsible for activation of the expression of the butanediol operon genes; contains the type 2 periplasmic binding fold; Region: PBP2_BudR; cd08451 1045856003749 putative dimerization interface [polypeptide binding]; other site 1045856003750 putative substrate binding pocket [chemical binding]; other site 1045856003751 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306 1045856003752 acetolactate synthase; Reviewed; Region: PRK08617 1045856003753 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1045856003754 PYR/PP interface [polypeptide binding]; other site 1045856003755 dimer interface [polypeptide binding]; other site 1045856003756 TPP binding site [chemical binding]; other site 1045856003757 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1045856003758 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 1045856003759 TPP-binding site [chemical binding]; other site 1045856003760 dimer interface [polypeptide binding]; other site 1045856003761 acetoin reductase; Validated; Region: PRK08643 1045856003762 meso-2,3-butanediol dehydrogenase-like, classical (c) SDRs; Region: meso-BDH-like_SDR_c; cd05366 1045856003763 NAD binding site [chemical binding]; other site 1045856003764 homotetramer interface [polypeptide binding]; other site 1045856003765 homodimer interface [polypeptide binding]; other site 1045856003766 active site 1045856003767 substrate binding site [chemical binding]; other site 1045856003768 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1045856003769 DNA-binding site [nucleotide binding]; DNA binding site 1045856003770 RNA-binding motif; other site 1045856003771 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1045856003772 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1045856003773 choline dehydrogenase; Validated; Region: PRK02106 1045856003774 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1045856003775 betaine aldehyde dehydrogenase; Provisional; Region: PRK13252 1045856003776 NAD+-dependent 4-trimethylaminobutyraldehyde dehydrogenase, ALDH family 9A1; Region: ALDH_F9_TMBADH; cd07090 1045856003777 tetrameric interface [polypeptide binding]; other site 1045856003778 NAD binding site [chemical binding]; other site 1045856003779 catalytic residues [active] 1045856003780 transcriptional regulator BetI; Validated; Region: PRK00767 1045856003781 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1045856003782 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 1045856003783 choline transport protein BetT; Provisional; Region: PRK09928 1045856003784 phosphopantetheinyltransferase component of enterobactin synthase multienzyme complex; Provisional; Region: PRK10251 1045856003785 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 1045856003786 outer membrane receptor FepA; Provisional; Region: PRK13524 1045856003787 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1045856003788 N-terminal plug; other site 1045856003789 ligand-binding site [chemical binding]; other site 1045856003790 enterobactin/ferric enterobactin esterase; Provisional; Region: PRK10439 1045856003791 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 1045856003792 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1045856003793 MbtH-like protein; Region: MbtH; cl01279 1045856003794 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 1045856003795 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1045856003796 acyl-activating enzyme (AAE) consensus motif; other site 1045856003797 AMP binding site [chemical binding]; other site 1045856003798 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1045856003799 iron-enterobactin transporter ATP-binding protein; Provisional; Region: PRK10253 1045856003800 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1045856003801 Walker A/P-loop; other site 1045856003802 ATP binding site [chemical binding]; other site 1045856003803 Q-loop/lid; other site 1045856003804 ABC transporter signature motif; other site 1045856003805 Walker B; other site 1045856003806 D-loop; other site 1045856003807 H-loop/switch region; other site 1045856003808 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1045856003809 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1045856003810 ABC-ATPase subunit interface; other site 1045856003811 dimer interface [polypeptide binding]; other site 1045856003812 putative PBP binding regions; other site 1045856003813 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1045856003814 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1045856003815 ABC-ATPase subunit interface; other site 1045856003816 dimer interface [polypeptide binding]; other site 1045856003817 putative PBP binding regions; other site 1045856003818 enterobactin exporter EntS; Provisional; Region: PRK10489 1045856003819 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1045856003820 putative substrate translocation pore; other site 1045856003821 iron-enterobactin transporter periplasmic binding protein; Provisional; Region: PRK10957 1045856003822 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1045856003823 siderophore binding site; other site 1045856003824 isochorismate synthase EntC; Provisional; Region: PRK15016 1045856003825 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1045856003826 enterobactin synthase subunit E; Provisional; Region: entE; PRK10946 1045856003827 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 1045856003828 acyl-activating enzyme (AAE) consensus motif; other site 1045856003829 active site 1045856003830 AMP binding site [chemical binding]; other site 1045856003831 substrate binding site [chemical binding]; other site 1045856003832 Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013 1045856003833 hydrophobic substrate binding pocket; other site 1045856003834 Isochorismatase family; Region: Isochorismatase; pfam00857 1045856003835 active site 1045856003836 conserved cis-peptide bond; other site 1045856003837 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 1045856003838 2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220 1045856003839 2,3 dihydro-2,3 dihydrozybenzoate dehydrogenases, classical (c) SDRs; Region: DH-DHB-DH_SDR_c; cd05331 1045856003840 putative NAD(P) binding site [chemical binding]; other site 1045856003841 active site 1045856003842 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1045856003843 CoenzymeA binding site [chemical binding]; other site 1045856003844 subunit interaction site [polypeptide binding]; other site 1045856003845 PHB binding site; other site 1045856003846 hypothetical protein; Provisional; Region: PRK07338 1045856003847 M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885 1045856003848 metal binding site [ion binding]; metal-binding site 1045856003849 dimer interface [polypeptide binding]; other site 1045856003850 hypothetical protein; Provisional; Region: PRK10519 1045856003851 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 1045856003852 carbon starvation protein A; Provisional; Region: PRK15015 1045856003853 Carbon starvation protein CstA; Region: CstA; pfam02554 1045856003854 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 1045856003855 Uncharacterized small protein [Function unknown]; Region: COG2879 1045856003856 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1045856003857 classical (c) SDRs; Region: SDR_c; cd05233 1045856003858 NAD(P) binding site [chemical binding]; other site 1045856003859 active site 1045856003860 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 1045856003861 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 1045856003862 putative active site [active] 1045856003863 metal binding site [ion binding]; metal-binding site 1045856003864 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1045856003865 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1045856003866 Walker A/P-loop; other site 1045856003867 ATP binding site [chemical binding]; other site 1045856003868 Q-loop/lid; other site 1045856003869 ABC transporter signature motif; other site 1045856003870 Walker B; other site 1045856003871 D-loop; other site 1045856003872 H-loop/switch region; other site 1045856003873 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1045856003874 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1045856003875 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1045856003876 TM-ABC transporter signature motif; other site 1045856003877 Methylthioribose-binding protein-like of ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_methylthioribose_binding_like; cd06305 1045856003878 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1045856003879 putative ligand binding site [chemical binding]; other site 1045856003880 Uncharacterized conserved protein [Function unknown]; Region: COG5276 1045856003881 methylthioribose kinase; Reviewed; Region: mtnK; PRK09550 1045856003882 S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512 1045856003883 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 1045856003884 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_3; cd08896 1045856003885 putative hydrophobic ligand binding site [chemical binding]; other site 1045856003886 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791 1045856003887 Cupin domain; Region: Cupin_2; cl17218 1045856003888 2,3-diketo-5-methylthio-1-phosphopentane phosphatase; Region: enolase-ppase; TIGR01691 1045856003889 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1045856003890 motif II; other site 1045856003891 methylthioribulose-1-phosphate dehydratase; Provisional; Region: PRK09220 1045856003892 intersubunit interface [polypeptide binding]; other site 1045856003893 active site 1045856003894 Zn2+ binding site [ion binding]; other site 1045856003895 methionine aminotransferase; Validated; Region: PRK09082 1045856003896 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1045856003897 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1045856003898 homodimer interface [polypeptide binding]; other site 1045856003899 catalytic residue [active] 1045856003900 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1045856003901 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1045856003902 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1045856003903 dimerization interface [polypeptide binding]; other site 1045856003904 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1045856003905 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1045856003906 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 1045856003907 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 1045856003908 catalytic residue [active] 1045856003909 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 1045856003910 catalytic residues [active] 1045856003911 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1045856003912 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1045856003913 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1045856003914 Ligand Binding Site [chemical binding]; other site 1045856003915 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 1045856003916 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1045856003917 NAD binding site [chemical binding]; other site 1045856003918 catalytic Zn binding site [ion binding]; other site 1045856003919 structural Zn binding site [ion binding]; other site 1045856003920 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 1045856003921 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1045856003922 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1045856003923 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1045856003924 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1045856003925 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 1045856003926 Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062 1045856003927 B1 nucleotide binding pocket [chemical binding]; other site 1045856003928 B2 nucleotide binding pocket [chemical binding]; other site 1045856003929 CAS motifs; other site 1045856003930 active site 1045856003931 C4-dicarboxylate transporter DcuC; Provisional; Region: dcuC; PRK10654 1045856003932 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 1045856003933 phospholipid:lipid A palmitoyltransferase; Provisional; Region: pagP; PRK11045 1045856003934 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1045856003935 DNA-binding site [nucleotide binding]; DNA binding site 1045856003936 RNA-binding motif; other site 1045856003937 chromosome condensation membrane protein; Provisional; Region: PRK14196 1045856003938 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1045856003939 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 1045856003940 putative active site [active] 1045856003941 catalytic triad [active] 1045856003942 putative dimer interface [polypeptide binding]; other site 1045856003943 twin arginine translocase protein E; Validated; Region: tatE; PRK03625 1045856003944 lipoyl synthase; Provisional; Region: PRK05481 1045856003945 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1045856003946 FeS/SAM binding site; other site 1045856003947 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11482 1045856003948 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1045856003949 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 1045856003950 substrate binding pocket [chemical binding]; other site 1045856003951 dimerization interface [polypeptide binding]; other site 1045856003952 lipoate-protein ligase B; Provisional; Region: PRK14342 1045856003953 hypothetical protein; Provisional; Region: PRK04998 1045856003954 D-alanyl-D-alanine carboxypeptidase fraction A; Provisional; Region: PRK10793 1045856003955 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1045856003956 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 1045856003957 rare lipoprotein A; Provisional; Region: PRK10672 1045856003958 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 1045856003959 Sporulation related domain; Region: SPOR; pfam05036 1045856003960 cell wall shape-determining protein; Provisional; Region: PRK10794 1045856003961 penicillin-binding protein 2; Provisional; Region: PRK10795 1045856003962 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1045856003963 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1045856003964 rRNA large subunit m3Psi methyltransferase RlmH; Region: tRNA_RlmH_YbeA; TIGR00246 1045856003965 ribosome-associated protein; Provisional; Region: PRK11538 1045856003966 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 1045856003967 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1045856003968 active site 1045856003969 (T/H)XGH motif; other site 1045856003970 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 1045856003971 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 1045856003972 LPS-assembly lipoprotein RlpB; Provisional; Region: PRK10796 1045856003973 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1045856003974 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1045856003975 HIGH motif; other site 1045856003976 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1045856003977 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1045856003978 active site 1045856003979 KMSKS motif; other site 1045856003980 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1045856003981 tRNA binding surface [nucleotide binding]; other site 1045856003982 hypothetical protein; Provisional; Region: PRK11032 1045856003983 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 1045856003984 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 1045856003985 active site 1045856003986 tetramer interface [polypeptide binding]; other site 1045856003987 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1045856003988 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1045856003989 Walker A/P-loop; other site 1045856003990 ATP binding site [chemical binding]; other site 1045856003991 Q-loop/lid; other site 1045856003992 ABC transporter signature motif; other site 1045856003993 Walker B; other site 1045856003994 D-loop; other site 1045856003995 H-loop/switch region; other site 1045856003996 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1045856003997 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1045856003998 dimer interface [polypeptide binding]; other site 1045856003999 conserved gate region; other site 1045856004000 putative PBP binding loops; other site 1045856004001 ABC-ATPase subunit interface; other site 1045856004002 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1045856004003 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1045856004004 dimer interface [polypeptide binding]; other site 1045856004005 conserved gate region; other site 1045856004006 putative PBP binding loops; other site 1045856004007 ABC-ATPase subunit interface; other site 1045856004008 glutamate and aspartate transporter subunit; Provisional; Region: PRK10797 1045856004009 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1045856004010 substrate binding pocket [chemical binding]; other site 1045856004011 membrane-bound complex binding site; other site 1045856004012 hinge residues; other site 1045856004013 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 1045856004014 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 1045856004015 putative active site [active] 1045856004016 catalytic triad [active] 1045856004017 putative dimer interface [polypeptide binding]; other site 1045856004018 magnesium/cobalt efflux protein CorC; Provisional; Region: PRK15094 1045856004019 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1045856004020 Transporter associated domain; Region: CorC_HlyC; smart01091 1045856004021 metal-binding heat shock protein; Provisional; Region: PRK00016 1045856004022 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1045856004023 PhoH-like protein; Region: PhoH; pfam02562 1045856004024 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 1045856004025 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1045856004026 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1045856004027 FeS/SAM binding site; other site 1045856004028 TRAM domain; Region: TRAM; pfam01938 1045856004029 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Reviewed; Region: ubiF; PRK08020 1045856004030 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1045856004031 asparagine synthetase B; Provisional; Region: asnB; PRK09431 1045856004032 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1045856004033 active site 1045856004034 dimer interface [polypeptide binding]; other site 1045856004035 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1045856004036 Ligand Binding Site [chemical binding]; other site 1045856004037 Molecular Tunnel; other site 1045856004038 UMP phosphatase; Provisional; Region: PRK10444 1045856004039 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1045856004040 active site 1045856004041 motif I; other site 1045856004042 motif II; other site 1045856004043 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1045856004044 MarR family; Region: MarR; pfam01047 1045856004045 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1045856004046 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1045856004047 nucleotide binding site [chemical binding]; other site 1045856004048 N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221 1045856004049 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 1045856004050 active site 1045856004051 dimer interface [polypeptide binding]; other site 1045856004052 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1045856004053 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 1045856004054 active site 1045856004055 trimer interface [polypeptide binding]; other site 1045856004056 allosteric site; other site 1045856004057 active site lid [active] 1045856004058 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1045856004059 PTS system N-acetyl glucosamine specific transporter subunits IIABC; Provisional; Region: PRK10255 1045856004060 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1045856004061 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1045856004062 active site turn [active] 1045856004063 phosphorylation site [posttranslational modification] 1045856004064 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 1045856004065 HPr interaction site; other site 1045856004066 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1045856004067 active site 1045856004068 phosphorylation site [posttranslational modification] 1045856004069 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 1045856004070 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1045856004071 active site 1045856004072 HIGH motif; other site 1045856004073 nucleotide binding site [chemical binding]; other site 1045856004074 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 1045856004075 KMSKS motif; other site 1045856004076 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 1045856004077 outer membrane porin, OprD family; Region: OprD; pfam03573 1045856004078 YbfN-like lipoprotein; Region: YbfN; pfam13982 1045856004079 ferric uptake regulator; Provisional; Region: fur; PRK09462 1045856004080 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1045856004081 metal binding site 2 [ion binding]; metal-binding site 1045856004082 putative DNA binding helix; other site 1045856004083 metal binding site 1 [ion binding]; metal-binding site 1045856004084 dimer interface [polypeptide binding]; other site 1045856004085 structural Zn2+ binding site [ion binding]; other site 1045856004086 flavodoxin FldA; Validated; Region: PRK09267 1045856004087 LexA regulated protein; Provisional; Region: PRK11675 1045856004088 acyl-CoA esterase; Provisional; Region: PRK10673 1045856004089 PGAP1-like protein; Region: PGAP1; pfam07819 1045856004090 replication initiation regulator SeqA; Provisional; Region: PRK11187 1045856004091 phosphoglucomutase; Validated; Region: PRK07564 1045856004092 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 1045856004093 active site 1045856004094 substrate binding site [chemical binding]; other site 1045856004095 metal binding site [ion binding]; metal-binding site 1045856004096 putrescine transporter; Provisional; Region: potE; PRK10655 1045856004097 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 1045856004098 ornithine decarboxylase; Provisional; Region: PRK13578 1045856004099 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 1045856004100 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 1045856004101 homodimer interface [polypeptide binding]; other site 1045856004102 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1045856004103 catalytic residue [active] 1045856004104 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1045856004105 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 1045856004106 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1045856004107 active site 1045856004108 phosphorylation site [posttranslational modification] 1045856004109 intermolecular recognition site; other site 1045856004110 dimerization interface [polypeptide binding]; other site 1045856004111 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1045856004112 DNA binding site [nucleotide binding] 1045856004113 sensor protein KdpD; Provisional; Region: PRK10490 1045856004114 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 1045856004115 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 1045856004116 Ligand Binding Site [chemical binding]; other site 1045856004117 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 1045856004118 GAF domain; Region: GAF_3; pfam13492 1045856004119 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1045856004120 dimer interface [polypeptide binding]; other site 1045856004121 phosphorylation site [posttranslational modification] 1045856004122 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1045856004123 ATP binding site [chemical binding]; other site 1045856004124 Mg2+ binding site [ion binding]; other site 1045856004125 G-X-G motif; other site 1045856004126 potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315 1045856004127 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 1045856004128 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1045856004129 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 1045856004130 Protein of unknown function (DUF2517); Region: DUF2517; pfam10725 1045856004131 deoxyribodipyrimidine photolyase; Provisional; Region: PRK10674 1045856004132 DNA photolyase; Region: DNA_photolyase; pfam00875 1045856004133 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1045856004134 metal-binding protein; Provisional; Region: PRK10799 1045856004135 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 1045856004136 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 1045856004137 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 1045856004138 LamB/YcsF family protein; Provisional; Region: PRK05406 1045856004139 endonuclease VIII; Provisional; Region: PRK10445 1045856004140 N-terminal domain of Escherichia coli Nei/endonuclease VIII and related DNA glycosylases; Region: EcNei-like_N; cd08965 1045856004141 DNA binding site [nucleotide binding] 1045856004142 catalytic residue [active] 1045856004143 putative catalytic residues [active] 1045856004144 H2TH interface [polypeptide binding]; other site 1045856004145 intercalation triad [nucleotide binding]; other site 1045856004146 substrate specificity determining residue; other site 1045856004147 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1045856004148 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1045856004149 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 1045856004150 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 1045856004151 dimer interface [polypeptide binding]; other site 1045856004152 active site 1045856004153 citrylCoA binding site [chemical binding]; other site 1045856004154 NADH binding [chemical binding]; other site 1045856004155 cationic pore residues; other site 1045856004156 oxalacetate/citrate binding site [chemical binding]; other site 1045856004157 coenzyme A binding site [chemical binding]; other site 1045856004158 catalytic triad [active] 1045856004159 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 1045856004160 Iron-sulfur protein interface; other site 1045856004161 proximal quinone binding site [chemical binding]; other site 1045856004162 SdhD (CybS) interface [polypeptide binding]; other site 1045856004163 proximal heme binding site [chemical binding]; other site 1045856004164 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 1045856004165 SdhC subunit interface [polypeptide binding]; other site 1045856004166 proximal heme binding site [chemical binding]; other site 1045856004167 cardiolipin binding site; other site 1045856004168 Iron-sulfur protein interface; other site 1045856004169 proximal quinone binding site [chemical binding]; other site 1045856004170 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08958 1045856004171 L-aspartate oxidase; Provisional; Region: PRK06175 1045856004172 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1045856004173 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 1045856004174 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1045856004175 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 1045856004176 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 1045856004177 TPP-binding site [chemical binding]; other site 1045856004178 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 1045856004179 dimer interface [polypeptide binding]; other site 1045856004180 PYR/PP interface [polypeptide binding]; other site 1045856004181 TPP binding site [chemical binding]; other site 1045856004182 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 1045856004183 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1045856004184 E3 interaction surface; other site 1045856004185 lipoyl attachment site [posttranslational modification]; other site 1045856004186 e3 binding domain; Region: E3_binding; pfam02817 1045856004187 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1045856004188 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 1045856004189 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 1045856004190 CoA-ligase; Region: Ligase_CoA; pfam00549 1045856004191 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 1045856004192 CoA binding domain; Region: CoA_binding; smart00881 1045856004193 CoA-ligase; Region: Ligase_CoA; pfam00549 1045856004194 DNA-binding transcriptional repressor MngR; Provisional; Region: PRK09764 1045856004195 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1045856004196 DNA-binding site [nucleotide binding]; DNA binding site 1045856004197 UTRA domain; Region: UTRA; pfam07702 1045856004198 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 1045856004199 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1045856004200 active site 1045856004201 phosphorylation site [posttranslational modification] 1045856004202 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1045856004203 active site 1045856004204 P-loop; other site 1045856004205 phosphorylation site [posttranslational modification] 1045856004206 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 1045856004207 alpha-mannosidase; Provisional; Region: PRK09819 1045856004208 N-terminal catalytic domain of Escherichia coli alpha-mannosidase MngB and its bacterial homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_EcMngB_like; cd10815 1045856004209 active site 1045856004210 metal binding site [ion binding]; metal-binding site 1045856004211 catalytic site [active] 1045856004212 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 1045856004213 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 1045856004214 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 1045856004215 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003 1045856004216 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1045856004217 Membrane bound YbgT-like protein; Region: YbgT_YccB; cl02039 1045856004218 hypothetical protein; Provisional; Region: PRK10588 1045856004219 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1045856004220 active site 1045856004221 colicin uptake protein TolQ; Provisional; Region: PRK10801 1045856004222 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1045856004223 colicin uptake protein TolR; Provisional; Region: PRK11024 1045856004224 cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510 1045856004225 TolA C-terminal; Region: TolA; pfam06519 1045856004226 translocation protein TolB; Provisional; Region: tolB; PRK03629 1045856004227 TolB amino-terminal domain; Region: TolB_N; pfam04052 1045856004228 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1045856004229 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1045856004230 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1045856004231 peptidoglycan-associated outer membrane lipoprotein; Provisional; Region: PRK10802 1045856004232 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1045856004233 ligand binding site [chemical binding]; other site 1045856004234 tol-pal system protein YbgF; Provisional; Region: PRK10803 1045856004235 Tetratricopeptide repeat; Region: TPR_6; pfam13174 1045856004236 quinolinate synthetase; Provisional; Region: PRK09375 1045856004237 nicotinamide riboside transporter PnuC; Provisional; Region: PRK15397 1045856004238 zinc transporter ZitB; Provisional; Region: PRK03557 1045856004239 YbgS-like protein; Region: YbgS; pfam13985 1045856004240 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 1045856004241 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1045856004242 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1045856004243 catalytic core [active] 1045856004244 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1045856004245 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 1045856004246 active site 1045856004247 catalytic residues [active] 1045856004248 galactokinase; Provisional; Region: PRK05101 1045856004249 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 1045856004250 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1045856004251 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1045856004252 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720 1045856004253 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 1045856004254 dimer interface [polypeptide binding]; other site 1045856004255 active site 1045856004256 UDP-galactose-4-epimerase; Provisional; Region: PRK10675 1045856004257 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 1045856004258 NAD binding site [chemical binding]; other site 1045856004259 homodimer interface [polypeptide binding]; other site 1045856004260 active site 1045856004261 substrate binding site [chemical binding]; other site 1045856004262 putative molybdenum transport ATP-binding protein ModF; Provisional; Region: PRK10938 1045856004263 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1045856004264 Walker A/P-loop; other site 1045856004265 ATP binding site [chemical binding]; other site 1045856004266 Q-loop/lid; other site 1045856004267 ABC transporter signature motif; other site 1045856004268 Walker B; other site 1045856004269 D-loop; other site 1045856004270 H-loop/switch region; other site 1045856004271 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1045856004272 Walker A/P-loop; other site 1045856004273 ATP binding site [chemical binding]; other site 1045856004274 Q-loop/lid; other site 1045856004275 ABC transporter signature motif; other site 1045856004276 Walker B; other site 1045856004277 D-loop; other site 1045856004278 H-loop/switch region; other site 1045856004279 DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676 1045856004280 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 1045856004281 molybdenum-pterin binding domain; Region: Mop; TIGR00638 1045856004282 TOBE domain; Region: TOBE; pfam03459 1045856004283 molybdate transporter periplasmic protein; Provisional; Region: modA; PRK10677 1045856004284 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1045856004285 substrate binding pocket [chemical binding]; other site 1045856004286 membrane-bound complex binding site; other site 1045856004287 hinge residues; other site 1045856004288 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1045856004289 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1045856004290 dimer interface [polypeptide binding]; other site 1045856004291 conserved gate region; other site 1045856004292 putative PBP binding loops; other site 1045856004293 ABC-ATPase subunit interface; other site 1045856004294 molybdate transporter ATP-binding protein; Provisional; Region: modC; PRK11144 1045856004295 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1045856004296 Walker A/P-loop; other site 1045856004297 ATP binding site [chemical binding]; other site 1045856004298 Q-loop/lid; other site 1045856004299 ABC transporter signature motif; other site 1045856004300 Walker B; other site 1045856004301 D-loop; other site 1045856004302 H-loop/switch region; other site 1045856004303 molybdenum-pterin binding domain; Region: Mop; TIGR00638 1045856004304 pyridoxal phosphate (PLP) phosphatase; Provisional; Region: PRK10530 1045856004305 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1045856004306 active site 1045856004307 motif I; other site 1045856004308 motif II; other site 1045856004309 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1045856004310 6-phosphogluconolactonase; Provisional; Region: PRK11028 1045856004311 acyl-CoA thioesterase; Provisional; Region: PRK10531 1045856004312 putative pectinesterase; Region: PLN02432; cl01911 1045856004313 imidazolonepropionase; Validated; Region: PRK09356 1045856004314 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 1045856004315 active site 1045856004316 Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988 1045856004317 putative active site [active] 1045856004318 putative metal binding site [ion binding]; other site 1045856004319 histidine utilization repressor; Provisional; Region: PRK14999 1045856004320 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1045856004321 DNA-binding site [nucleotide binding]; DNA binding site 1045856004322 UTRA domain; Region: UTRA; pfam07702 1045856004323 urocanate hydratase; Provisional; Region: PRK05414 1045856004324 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 1045856004325 active sites [active] 1045856004326 tetramer interface [polypeptide binding]; other site 1045856004327 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1045856004328 substrate binding site [chemical binding]; other site 1045856004329 adenosylmethionine--8-amino-7-oxononanoate transaminase; Validated; Region: PRK07986 1045856004330 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1045856004331 inhibitor-cofactor binding pocket; inhibition site 1045856004332 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1045856004333 catalytic residue [active] 1045856004334 biotin synthase; Provisional; Region: PRK15108 1045856004335 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1045856004336 FeS/SAM binding site; other site 1045856004337 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 1045856004338 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 1045856004339 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1045856004340 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1045856004341 catalytic residue [active] 1045856004342 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 1045856004343 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1045856004344 S-adenosylmethionine binding site [chemical binding]; other site 1045856004345 AAA domain; Region: AAA_26; pfam13500 1045856004346 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1045856004347 Dethiobiotin synthetase (DTBS) is the penultimate enzyme in the biotin biosynthesis pathway in Escherichia coli and other microorganisms. The enzyme catalyzes formation of the ureido ring of dethiobiotin from (7R,8S)-7,8-diaminononanoic acid (DAPA) and...; Region: DTBS; cd03109 1045856004348 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 1045856004349 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1045856004350 Walker A/P-loop; other site 1045856004351 ATP binding site [chemical binding]; other site 1045856004352 Q-loop/lid; other site 1045856004353 ABC transporter signature motif; other site 1045856004354 Walker B; other site 1045856004355 D-loop; other site 1045856004356 H-loop/switch region; other site 1045856004357 excinuclease ABC subunit B; Provisional; Region: PRK05298 1045856004358 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1045856004359 ATP binding site [chemical binding]; other site 1045856004360 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1045856004361 nucleotide binding region [chemical binding]; other site 1045856004362 ATP-binding site [chemical binding]; other site 1045856004363 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1045856004364 UvrB/uvrC motif; Region: UVR; pfam02151 1045856004365 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 1045856004366 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 1045856004367 phosphate binding site [ion binding]; other site 1045856004368 putative substrate binding pocket [chemical binding]; other site 1045856004369 dimer interface [polypeptide binding]; other site 1045856004370 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 1045856004371 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1045856004372 FeS/SAM binding site; other site 1045856004373 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1045856004374 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1045856004375 MPT binding site; other site 1045856004376 trimer interface [polypeptide binding]; other site 1045856004377 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 1045856004378 trimer interface [polypeptide binding]; other site 1045856004379 dimer interface [polypeptide binding]; other site 1045856004380 putative active site [active] 1045856004381 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1045856004382 MoaE interaction surface [polypeptide binding]; other site 1045856004383 MoeB interaction surface [polypeptide binding]; other site 1045856004384 thiocarboxylated glycine; other site 1045856004385 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 1045856004386 MoaE homodimer interface [polypeptide binding]; other site 1045856004387 MoaD interaction [polypeptide binding]; other site 1045856004388 active site residues [active] 1045856004389 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 1045856004390 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 1045856004391 Predicted integral membrane protein [Function unknown]; Region: COG0392 1045856004392 cardiolipin synthase 2; Provisional; Region: PRK11263 1045856004393 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1045856004394 putative active site [active] 1045856004395 catalytic site [active] 1045856004396 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 1045856004397 putative active site [active] 1045856004398 catalytic site [active] 1045856004399 Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568 1045856004400 putative catalytic site [active] 1045856004401 putative metal binding site [ion binding]; other site 1045856004402 putative phosphate binding site [ion binding]; other site 1045856004403 Putative inner membrane protein YbhQ; Region: YbhQ; pfam11076 1045856004404 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1045856004405 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1045856004406 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1045856004407 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 1045856004408 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1045856004409 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1045856004410 Walker A/P-loop; other site 1045856004411 ATP binding site [chemical binding]; other site 1045856004412 Q-loop/lid; other site 1045856004413 ABC transporter signature motif; other site 1045856004414 Walker B; other site 1045856004415 D-loop; other site 1045856004416 H-loop/switch region; other site 1045856004417 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1045856004418 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1045856004419 Walker A/P-loop; other site 1045856004420 ATP binding site [chemical binding]; other site 1045856004421 Q-loop/lid; other site 1045856004422 ABC transporter signature motif; other site 1045856004423 Walker B; other site 1045856004424 D-loop; other site 1045856004425 H-loop/switch region; other site 1045856004426 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 1045856004427 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1045856004428 HlyD family secretion protein; Region: HlyD_3; pfam13437 1045856004429 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11552 1045856004430 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1045856004431 Domain of unknown function (DUF1956); Region: DUF1956; pfam09209 1045856004432 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 1045856004433 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1045856004434 ATP binding site [chemical binding]; other site 1045856004435 Mg++ binding site [ion binding]; other site 1045856004436 motif III; other site 1045856004437 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1045856004438 nucleotide binding region [chemical binding]; other site 1045856004439 ATP-binding site [chemical binding]; other site 1045856004440 ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747 1045856004441 DEAD_2; Region: DEAD_2; pfam06733 1045856004442 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1045856004443 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1045856004444 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1045856004445 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 1045856004446 PapC N-terminal domain; Region: PapC_N; pfam13954 1045856004447 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1045856004448 PapC C-terminal domain; Region: PapC_C; pfam13953 1045856004449 fimbrial assembly chaperone SthB; Provisional; Region: PRK15295 1045856004450 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1045856004451 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1045856004452 Fimbrial protein; Region: Fimbrial; cl01416 1045856004453 glycosyl transferase family protein; Provisional; Region: PRK08136 1045856004454 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1045856004455 hypothetical protein; Provisional; Region: PRK10259 1045856004456 hypothetical protein; Provisional; Region: PRK11019 1045856004457 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1045856004458 23S rRNA mA1618 methyltransferase; Provisional; Region: PRK11727 1045856004459 Protein of unknown function (DUF890); Region: Methyltransf_10; pfam05971 1045856004460 putative mechanosensitive channel protein; Provisional; Region: PRK11465 1045856004461 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1045856004462 glutamine ABC transporter ATP-binding protein; Reviewed; Region: glnQ; PRK09493 1045856004463 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1045856004464 Walker A/P-loop; other site 1045856004465 ATP binding site [chemical binding]; other site 1045856004466 Q-loop/lid; other site 1045856004467 ABC transporter signature motif; other site 1045856004468 Walker B; other site 1045856004469 D-loop; other site 1045856004470 H-loop/switch region; other site 1045856004471 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1045856004472 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1045856004473 dimer interface [polypeptide binding]; other site 1045856004474 conserved gate region; other site 1045856004475 putative PBP binding loops; other site 1045856004476 ABC-ATPase subunit interface; other site 1045856004477 glutamine ABC transporter periplasmic protein; Reviewed; Region: glnH; PRK09495 1045856004478 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1045856004479 substrate binding pocket [chemical binding]; other site 1045856004480 membrane-bound complex binding site; other site 1045856004481 hinge residues; other site 1045856004482 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1045856004483 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1045856004484 dimerization interface [polypeptide binding]; other site 1045856004485 DPS ferroxidase diiron center [ion binding]; other site 1045856004486 ion pore; other site 1045856004487 threonine and homoserine efflux system; Provisional; Region: PRK10532 1045856004488 EamA-like transporter family; Region: EamA; pfam00892 1045856004489 outer membrane protein X; Provisional; Region: ompX; PRK09408 1045856004490 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 1045856004491 Sulfatase; Region: Sulfatase; pfam00884 1045856004492 manganese transport regulator MntR; Provisional; Region: PRK11050 1045856004493 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 1045856004494 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1045856004495 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1045856004496 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117 1045856004497 transmembrane helices; other site 1045856004498 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 1045856004499 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1045856004500 HlyD family secretion protein; Region: HlyD_3; pfam13437 1045856004501 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1045856004502 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1045856004503 putative substrate translocation pore; other site 1045856004504 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1045856004505 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 1045856004506 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1045856004507 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1045856004508 active site 1045856004509 catalytic tetrad [active] 1045856004510 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 1045856004511 beta-galactosidase; Region: BGL; TIGR03356 1045856004512 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 1045856004513 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 1045856004514 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1045856004515 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1045856004516 DNA-binding site [nucleotide binding]; DNA binding site 1045856004517 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 1045856004518 L,D-transpeptidase; Provisional; Region: PRK10260 1045856004519 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1045856004520 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 1045856004521 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1045856004522 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1045856004523 Walker A/P-loop; other site 1045856004524 ATP binding site [chemical binding]; other site 1045856004525 Q-loop/lid; other site 1045856004526 ABC transporter signature motif; other site 1045856004527 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1045856004528 Walker B; other site 1045856004529 D-loop; other site 1045856004530 ABC transporter; Region: ABC_tran_2; pfam12848 1045856004531 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1045856004532 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 1045856004533 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 1045856004534 Glycosyl hydrolase family 31 (GH31) domain of a bacterial protein family represented by Escherichia coli protein Aec37. The gene encoding Aec37 (aec-37) is located within a genomic island (AGI-3) isolated from the extraintestinal avian pathogenic...; Region: GH31_glycosidase_Aec37; cd06599 1045856004535 putative active site [active] 1045856004536 putative catalytic site [active] 1045856004537 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1045856004538 D-galactonate transporter; Region: 2A0114; TIGR00893 1045856004539 putative substrate translocation pore; other site 1045856004540 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1045856004541 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1045856004542 DNA binding site [nucleotide binding] 1045856004543 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1045856004544 ligand binding site [chemical binding]; other site 1045856004545 dimerization interface [polypeptide binding]; other site 1045856004546 Protein of unknown function (DUF1479); Region: DUF1479; pfam07350 1045856004547 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 1045856004548 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1045856004549 active site 1045856004550 motif I; other site 1045856004551 motif II; other site 1045856004552 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1045856004553 glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774 1045856004554 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 1045856004555 dimer interface [polypeptide binding]; other site 1045856004556 active site 1045856004557 glycine loop; other site 1045856004558 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 1045856004559 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1045856004560 FeS/SAM binding site; other site 1045856004561 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 1045856004562 active site 1045856004563 intersubunit interactions; other site 1045856004564 catalytic residue [active] 1045856004565 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 1045856004566 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1045856004567 ATP binding site [chemical binding]; other site 1045856004568 substrate interface [chemical binding]; other site 1045856004569 molybdopterin biosynthesis protein MoeA; Provisional; Region: PRK10680 1045856004570 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1045856004571 dimer interface [polypeptide binding]; other site 1045856004572 putative functional site; other site 1045856004573 putative MPT binding site; other site 1045856004574 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 1045856004575 catalytic nucleophile [active] 1045856004576 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 1045856004577 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1045856004578 Walker A/P-loop; other site 1045856004579 ATP binding site [chemical binding]; other site 1045856004580 Q-loop/lid; other site 1045856004581 ABC transporter signature motif; other site 1045856004582 Walker B; other site 1045856004583 D-loop; other site 1045856004584 H-loop/switch region; other site 1045856004585 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1045856004586 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1045856004587 Walker A/P-loop; other site 1045856004588 ATP binding site [chemical binding]; other site 1045856004589 Q-loop/lid; other site 1045856004590 ABC transporter signature motif; other site 1045856004591 Walker B; other site 1045856004592 D-loop; other site 1045856004593 H-loop/switch region; other site 1045856004594 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 1045856004595 glutathione ABC transporter substrate-binding protein GsiB; Provisional; Region: PRK15413 1045856004596 The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499 1045856004597 glutathione ABC transporter permease GsiC; Provisional; Region: PRK15081 1045856004598 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1045856004599 dimer interface [polypeptide binding]; other site 1045856004600 conserved gate region; other site 1045856004601 putative PBP binding loops; other site 1045856004602 ABC-ATPase subunit interface; other site 1045856004603 glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082 1045856004604 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1045856004605 dimer interface [polypeptide binding]; other site 1045856004606 conserved gate region; other site 1045856004607 putative PBP binding loops; other site 1045856004608 ABC-ATPase subunit interface; other site 1045856004609 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 1045856004610 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1045856004611 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1045856004612 FeS/SAM binding site; other site 1045856004613 biofilm formation regulatory protein BssR; Reviewed; Region: bssR; PRK12302 1045856004614 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 1045856004615 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 1045856004616 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1045856004617 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 1045856004618 putative C-terminal domain interface [polypeptide binding]; other site 1045856004619 putative GSH binding site (G-site) [chemical binding]; other site 1045856004620 putative dimer interface [polypeptide binding]; other site 1045856004621 C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180 1045856004622 putative N-terminal domain interface [polypeptide binding]; other site 1045856004623 putative dimer interface [polypeptide binding]; other site 1045856004624 putative substrate binding pocket (H-site) [chemical binding]; other site 1045856004625 D-alanyl-D-alanine carboxypeptidase fraction C; Provisional; Region: PRK10001 1045856004626 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1045856004627 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 1045856004628 DNA-binding transcriptional repressor DeoR; Provisional; Region: PRK10681 1045856004629 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1045856004630 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1045856004631 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 1045856004632 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1045856004633 active site 1045856004634 PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396 1045856004635 active site 1045856004636 multidrug efflux system translocase MdfA; Provisional; Region: PRK15402 1045856004637 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1045856004638 putative substrate translocation pore; other site 1045856004639 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1045856004640 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1045856004641 active site 1045856004642 motif I; other site 1045856004643 motif II; other site 1045856004644 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1045856004645 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1045856004646 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1045856004647 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1045856004648 putative substrate translocation pore; other site 1045856004649 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1045856004650 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1045856004651 short chain dehydrogenase; Provisional; Region: PRK07890 1045856004652 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1045856004653 NAD(P) binding site [chemical binding]; other site 1045856004654 active site 1045856004655 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 1045856004656 ArsC family; Region: ArsC; pfam03960 1045856004657 catalytic residues [active] 1045856004658 arsenical pump membrane protein; Provisional; Region: PRK15445 1045856004659 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 1045856004660 transmembrane helices; other site 1045856004661 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1045856004662 dimerization interface [polypeptide binding]; other site 1045856004663 putative DNA binding site [nucleotide binding]; other site 1045856004664 putative Zn2+ binding site [ion binding]; other site 1045856004665 putative transporter; Provisional; Region: PRK04972 1045856004666 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 1045856004667 TrkA-C domain; Region: TrkA_C; pfam02080 1045856004668 TrkA-C domain; Region: TrkA_C; pfam02080 1045856004669 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 1045856004670 Putative inner membrane protein of Enterobacteriaceae; Region: YbjM; pfam11045 1045856004671 Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066 1045856004672 GSH binding site [chemical binding]; other site 1045856004673 catalytic residues [active] 1045856004674 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 1045856004675 dimer interface [polypeptide binding]; other site 1045856004676 FMN binding site [chemical binding]; other site 1045856004677 NADPH bind site [chemical binding]; other site 1045856004678 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 1045856004679 RimK-like ATP-grasp domain; Region: RimK; pfam08443 1045856004680 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 1045856004681 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 1045856004682 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1045856004683 putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607 1045856004684 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1045856004685 Walker A/P-loop; other site 1045856004686 ATP binding site [chemical binding]; other site 1045856004687 Q-loop/lid; other site 1045856004688 ABC transporter signature motif; other site 1045856004689 Walker B; other site 1045856004690 D-loop; other site 1045856004691 H-loop/switch region; other site 1045856004692 TOBE domain; Region: TOBE_2; pfam08402 1045856004693 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 1045856004694 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1045856004695 dimer interface [polypeptide binding]; other site 1045856004696 conserved gate region; other site 1045856004697 putative PBP binding loops; other site 1045856004698 ABC-ATPase subunit interface; other site 1045856004699 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1045856004700 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1045856004701 dimer interface [polypeptide binding]; other site 1045856004702 conserved gate region; other site 1045856004703 putative PBP binding loops; other site 1045856004704 ABC-ATPase subunit interface; other site 1045856004705 Protein of unknown function (DUF2593); Region: DUF2593; pfam10767 1045856004706 23S rRNA (uracil-5-)-methyltransferase RumB; Region: meth_trns_rumB; TIGR02085 1045856004707 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1045856004708 S-adenosylmethionine binding site [chemical binding]; other site 1045856004709 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1045856004710 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1045856004711 active site 1045856004712 phosphorylation site [posttranslational modification] 1045856004713 intermolecular recognition site; other site 1045856004714 dimerization interface [polypeptide binding]; other site 1045856004715 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1045856004716 DNA binding site [nucleotide binding] 1045856004717 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 1045856004718 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1045856004719 dimer interface [polypeptide binding]; other site 1045856004720 phosphorylation site [posttranslational modification] 1045856004721 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1045856004722 ATP binding site [chemical binding]; other site 1045856004723 Mg2+ binding site [ion binding]; other site 1045856004724 G-X-G motif; other site 1045856004725 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1045856004726 substrate binding pocket [chemical binding]; other site 1045856004727 membrane-bound complex binding site; other site 1045856004728 hinge residues; other site 1045856004729 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1045856004730 dimer interface [polypeptide binding]; other site 1045856004731 conserved gate region; other site 1045856004732 putative PBP binding loops; other site 1045856004733 ABC-ATPase subunit interface; other site 1045856004734 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1045856004735 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1045856004736 dimer interface [polypeptide binding]; other site 1045856004737 conserved gate region; other site 1045856004738 putative PBP binding loops; other site 1045856004739 ABC-ATPase subunit interface; other site 1045856004740 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 1045856004741 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1045856004742 substrate binding pocket [chemical binding]; other site 1045856004743 membrane-bound complex binding site; other site 1045856004744 hinge residues; other site 1045856004745 arginine transporter ATP-binding subunit; Provisional; Region: artP; PRK11124 1045856004746 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1045856004747 Walker A/P-loop; other site 1045856004748 ATP binding site [chemical binding]; other site 1045856004749 Q-loop/lid; other site 1045856004750 ABC transporter signature motif; other site 1045856004751 Walker B; other site 1045856004752 D-loop; other site 1045856004753 H-loop/switch region; other site 1045856004754 putative lipoprotein; Provisional; Region: PRK10533 1045856004755 hypothetical protein; Provisional; Region: PRK02877 1045856004756 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 1045856004757 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1045856004758 amidase catalytic site [active] 1045856004759 Zn binding residues [ion binding]; other site 1045856004760 substrate binding site [chemical binding]; other site 1045856004761 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11832 1045856004762 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 1045856004763 ligand binding site [chemical binding]; other site 1045856004764 flexible hinge region; other site 1045856004765 Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267 1045856004766 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1045856004767 type II secretion system protein C; Region: typeII_sec_gspC; TIGR01713 1045856004768 Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356 1045856004769 type II secretion system protein D; Region: type_II_gspD; TIGR02517 1045856004770 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1045856004771 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1045856004772 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1045856004773 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1045856004774 type II secretion system protein E; Region: type_II_gspE; TIGR02533 1045856004775 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 1045856004776 Walker A motif; other site 1045856004777 ATP binding site [chemical binding]; other site 1045856004778 Walker B motif; other site 1045856004779 type II secretion system protein F; Region: GspF; TIGR02120 1045856004780 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1045856004781 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1045856004782 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 1045856004783 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 1045856004784 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 1045856004785 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 1045856004786 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 1045856004787 Type II transport protein GspH; Region: GspH; pfam12019 1045856004788 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 1045856004789 type II secretion system protein I; Region: gspI; TIGR01707 1045856004790 Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501 1045856004791 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 1045856004792 type II secretion system protein J; Region: gspJ; TIGR01711 1045856004793 Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612 1045856004794 Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934 1045856004795 type II secretion system protein L; Region: typeII_sec_gspL; TIGR01709 1045856004796 Type II secretion system (T2SS), protein L; Region: T2SL; pfam05134 1045856004797 GspL periplasmic domain; Region: GspL_C; cl14909 1045856004798 Type II secretion system (T2SS), protein M; Region: T2SM; pfam04612 1045856004799 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 1045856004800 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 1045856004801 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 1045856004802 N-terminal Early set domain associated with the catalytic domain of chitinase; Region: E_set_Chitinase_N; cd02848 1045856004803 Glyco_18 domain; Region: Glyco_18; smart00636 1045856004804 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 1045856004805 active site 1045856004806 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 1045856004807 aromatic chitin/cellulose binding site residues [chemical binding]; other site 1045856004808 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 1045856004809 aromatic chitin/cellulose binding site residues [chemical binding]; other site 1045856004810 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1045856004811 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1045856004812 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1045856004813 catalytic residue [active] 1045856004814 Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979 1045856004815 Glycoside hydrolase family 19 chitinase domain. Chitinases are enzymes that catalyze the hydrolysis of the beta-1,4-N-acetyl-D-glucosamine linkages in chitin polymers. Family 19 chitinases are found primarily in plants (classes I, III, and IV), but some...; Region: chitinase_glyco_hydro_19; cd00325 1045856004816 putative sugar binding site [chemical binding]; other site 1045856004817 catalytic residues [active] 1045856004818 Predicted coiled-coil domain-containing protein (DUF2360); Region: DUF2360; pfam10152 1045856004819 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 1045856004820 Chitin/cellulose binding domains of chitinase and related enzymes; Region: ChtBD3; cl00046 1045856004821 aromatic chitin/cellulose binding site residues [chemical binding]; other site 1045856004822 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1045856004823 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1045856004824 NAD(P) binding site [chemical binding]; other site 1045856004825 active site 1045856004826 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1045856004827 atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245 1045856004828 putative NAD(P) binding site [chemical binding]; other site 1045856004829 putative active site [active] 1045856004830 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 1045856004831 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 1045856004832 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 1045856004833 tetramer interface [polypeptide binding]; other site 1045856004834 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1045856004835 catalytic residue [active] 1045856004836 pyruvate dehydrogenase; Provisional; Region: PRK09124 1045856004837 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 1045856004838 PYR/PP interface [polypeptide binding]; other site 1045856004839 dimer interface [polypeptide binding]; other site 1045856004840 tetramer interface [polypeptide binding]; other site 1045856004841 TPP binding site [chemical binding]; other site 1045856004842 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1045856004843 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 1045856004844 TPP-binding site [chemical binding]; other site 1045856004845 DoxX; Region: DoxX; pfam07681 1045856004846 HCP oxidoreductase, NADH-dependent; Provisional; Region: PRK10684 1045856004847 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 1045856004848 FAD binding pocket [chemical binding]; other site 1045856004849 FAD binding motif [chemical binding]; other site 1045856004850 phosphate binding motif [ion binding]; other site 1045856004851 beta-alpha-beta structure motif; other site 1045856004852 NAD binding pocket [chemical binding]; other site 1045856004853 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1045856004854 catalytic loop [active] 1045856004855 iron binding site [ion binding]; other site 1045856004856 hybrid cluster protein; Provisional; Region: PRK05290 1045856004857 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1045856004858 ACS interaction site; other site 1045856004859 CODH interaction site; other site 1045856004860 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 1045856004861 hybrid metal cluster; other site 1045856004862 Predicted membrane protein [Function unknown]; Region: COG2431 1045856004863 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 1045856004864 amphipathic channel; other site 1045856004865 Asn-Pro-Ala signature motifs; other site 1045856004866 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 1045856004867 Protein of unknown function (DUF2813); Region: DUF2813; pfam11398 1045856004868 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 1045856004869 putative active site [active] 1045856004870 putative metal-binding site [ion binding]; other site 1045856004871 Protein of unknown function (DUF535); Region: DUF535; pfam04393 1045856004872 macrolide transporter subunit MacA; Provisional; Region: PRK11578 1045856004873 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1045856004874 HlyD family secretion protein; Region: HlyD_3; pfam13437 1045856004875 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 1045856004876 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1045856004877 Walker A/P-loop; other site 1045856004878 ATP binding site [chemical binding]; other site 1045856004879 Q-loop/lid; other site 1045856004880 ABC transporter signature motif; other site 1045856004881 Walker B; other site 1045856004882 D-loop; other site 1045856004883 H-loop/switch region; other site 1045856004884 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1045856004885 FtsX-like permease family; Region: FtsX; pfam02687 1045856004886 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1045856004887 DNA-binding site [nucleotide binding]; DNA binding site 1045856004888 RNA-binding motif; other site 1045856004889 Uncharacterized conserved protein [Function unknown]; Region: COG2127 1045856004890 ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034 1045856004891 Clp amino terminal domain; Region: Clp_N; pfam02861 1045856004892 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1045856004893 Walker A motif; other site 1045856004894 ATP binding site [chemical binding]; other site 1045856004895 Walker B motif; other site 1045856004896 arginine finger; other site 1045856004897 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1045856004898 Walker A motif; other site 1045856004899 ATP binding site [chemical binding]; other site 1045856004900 Walker B motif; other site 1045856004901 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1045856004902 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1045856004903 rRNA binding site [nucleotide binding]; other site 1045856004904 predicted 30S ribosome binding site; other site 1045856004905 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 1045856004906 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160 1045856004907 Domain of unknown function (DUF4173); Region: DUF4173; pfam13777 1045856004908 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1045856004909 Walker A/P-loop; other site 1045856004910 ATP binding site [chemical binding]; other site 1045856004911 Q-loop/lid; other site 1045856004912 ABC transporter signature motif; other site 1045856004913 Walker B; other site 1045856004914 D-loop; other site 1045856004915 H-loop/switch region; other site 1045856004916 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11174 1045856004917 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1045856004918 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1045856004919 Walker A/P-loop; other site 1045856004920 ATP binding site [chemical binding]; other site 1045856004921 Q-loop/lid; other site 1045856004922 ABC transporter signature motif; other site 1045856004923 Walker B; other site 1045856004924 D-loop; other site 1045856004925 H-loop/switch region; other site 1045856004926 thioredoxin reductase; Provisional; Region: PRK10262 1045856004927 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1045856004928 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1045856004929 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 1045856004930 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1045856004931 putative DNA binding site [nucleotide binding]; other site 1045856004932 putative Zn2+ binding site [ion binding]; other site 1045856004933 AsnC family; Region: AsnC_trans_reg; pfam01037 1045856004934 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 1045856004935 Protein of unknown function (DUF998); Region: DUF998; pfam06197 1045856004936 DNA translocase FtsK; Provisional; Region: PRK10263 1045856004937 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1045856004938 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 1045856004939 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 1045856004940 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 1045856004941 recombination factor protein RarA; Reviewed; Region: PRK13342 1045856004942 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1045856004943 Walker A motif; other site 1045856004944 ATP binding site [chemical binding]; other site 1045856004945 Walker B motif; other site 1045856004946 arginine finger; other site 1045856004947 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1045856004948 seryl-tRNA synthetase; Provisional; Region: PRK05431 1045856004949 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1045856004950 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1045856004951 dimer interface [polypeptide binding]; other site 1045856004952 active site 1045856004953 motif 1; other site 1045856004954 motif 2; other site 1045856004955 motif 3; other site 1045856004956 anaerobic dimethyl sulfoxide reductase subunit A; Provisional; Region: PRK14990 1045856004957 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 1045856004958 putative [Fe4-S4] binding site [ion binding]; other site 1045856004959 putative molybdopterin cofactor binding site [chemical binding]; other site 1045856004960 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 1045856004961 putative molybdopterin cofactor binding site; other site 1045856004962 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 1045856004963 4Fe-4S binding domain; Region: Fer4; pfam00037 1045856004964 DMSO reductase anchor subunit (DmsC); Region: DmsC; pfam04976 1045856004965 putative MFS family transporter protein; Provisional; Region: PRK03633 1045856004966 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1045856004967 putative substrate translocation pore; other site 1045856004968 pyruvate formate lyase-activating enzyme 1; Provisional; Region: pflA; PRK11145 1045856004969 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1045856004970 FeS/SAM binding site; other site 1045856004971 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 1045856004972 Pyruvate formate lyase 1; Region: PFL1; cd01678 1045856004973 coenzyme A binding site [chemical binding]; other site 1045856004974 active site 1045856004975 catalytic residues [active] 1045856004976 glycine loop; other site 1045856004977 formate transporter; Provisional; Region: PRK10805 1045856004978 uncharacterized domain; Region: TIGR00702 1045856004979 YcaO-like family; Region: YcaO; pfam02624 1045856004980 Predicted membrane protein [Function unknown]; Region: COG2323 1045856004981 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 1045856004982 homodimer interface [polypeptide binding]; other site 1045856004983 substrate-cofactor binding pocket; other site 1045856004984 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1045856004985 catalytic residue [active] 1045856004986 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 1045856004987 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288 1045856004988 putative active site [active] 1045856004989 cytidylate kinase; Provisional; Region: cmk; PRK00023 1045856004990 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1045856004991 CMP-binding site; other site 1045856004992 The sites determining sugar specificity; other site 1045856004993 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 1045856004994 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1045856004995 RNA binding site [nucleotide binding]; other site 1045856004996 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 1045856004997 RNA binding site [nucleotide binding]; other site 1045856004998 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689 1045856004999 RNA binding site [nucleotide binding]; other site 1045856005000 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 1045856005001 RNA binding site [nucleotide binding]; other site 1045856005002 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 1045856005003 RNA binding site [nucleotide binding]; other site 1045856005004 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1045856005005 IHF dimer interface [polypeptide binding]; other site 1045856005006 IHF - DNA interface [nucleotide binding]; other site 1045856005007 ComEC family competence protein; Provisional; Region: PRK11539 1045856005008 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 1045856005009 Competence protein; Region: Competence; pfam03772 1045856005010 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 1045856005011 lipid transporter ATP-binding/permease protein; Provisional; Region: PRK11176 1045856005012 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1045856005013 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1045856005014 Walker A/P-loop; other site 1045856005015 ATP binding site [chemical binding]; other site 1045856005016 Q-loop/lid; other site 1045856005017 ABC transporter signature motif; other site 1045856005018 Walker B; other site 1045856005019 D-loop; other site 1045856005020 H-loop/switch region; other site 1045856005021 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 1045856005022 tetraacyldisaccharide 4'-kinase; Region: lpxK; TIGR00682 1045856005023 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 1045856005024 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 1045856005025 Trm112p-like protein; Region: Trm112p; cl01066 1045856005026 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 1045856005027 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 1045856005028 Ligand binding site; other site 1045856005029 oligomer interface; other site 1045856005030 hypothetical protein; Provisional; Region: PRK10593 1045856005031 Uncharacterized conserved protein [Function unknown]; Region: COG1434 1045856005032 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1045856005033 putative active site [active] 1045856005034 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1045856005035 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1045856005036 S-adenosylmethionine binding site [chemical binding]; other site 1045856005037 condesin subunit F; Provisional; Region: PRK05260 1045856005038 condesin subunit E; Provisional; Region: PRK05256 1045856005039 cell division protein MukB; Provisional; Region: mukB; PRK04863 1045856005040 P-loop containing region of AAA domain; Region: AAA_29; cl17516 1045856005041 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 1045856005042 murein L,D-transpeptidase; Provisional; Region: PRK10594 1045856005043 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1045856005044 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1045856005045 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1045856005046 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 1045856005047 Peptidase M15; Region: Peptidase_M15_3; cl01194 1045856005048 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1045856005049 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 1045856005050 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1045856005051 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1045856005052 homodimer interface [polypeptide binding]; other site 1045856005053 catalytic residue [active] 1045856005054 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1045856005055 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 1045856005056 trimer interface [polypeptide binding]; other site 1045856005057 eyelet of channel; other site 1045856005058 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 1045856005059 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 1045856005060 putative dimer interface [polypeptide binding]; other site 1045856005061 putative anticodon binding site; other site 1045856005062 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 1045856005063 homodimer interface [polypeptide binding]; other site 1045856005064 motif 1; other site 1045856005065 motif 2; other site 1045856005066 active site 1045856005067 motif 3; other site 1045856005068 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 1045856005069 Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401 1045856005070 active site 1045856005071 aminopeptidase N; Provisional; Region: pepN; PRK14015 1045856005072 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 1045856005073 active site 1045856005074 Zn binding site [ion binding]; other site 1045856005075 aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247 1045856005076 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1045856005077 Walker A/P-loop; other site 1045856005078 ATP binding site [chemical binding]; other site 1045856005079 Q-loop/lid; other site 1045856005080 ABC transporter signature motif; other site 1045856005081 Walker B; other site 1045856005082 D-loop; other site 1045856005083 H-loop/switch region; other site 1045856005084 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1045856005085 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1045856005086 dimer interface [polypeptide binding]; other site 1045856005087 conserved gate region; other site 1045856005088 putative PBP binding loops; other site 1045856005089 ABC-ATPase subunit interface; other site 1045856005090 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 1045856005091 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 1045856005092 active site 1045856005093 dimer interface [polypeptide binding]; other site 1045856005094 non-prolyl cis peptide bond; other site 1045856005095 insertion regions; other site 1045856005096 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1045856005097 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1045856005098 substrate binding pocket [chemical binding]; other site 1045856005099 membrane-bound complex binding site; other site 1045856005100 hinge residues; other site 1045856005101 NAD(P)H-dependent FMN reductase; Provisional; Region: PRK10569 1045856005102 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1045856005103 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 1045856005104 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 1045856005105 quinone interaction residues [chemical binding]; other site 1045856005106 active site 1045856005107 catalytic residues [active] 1045856005108 FMN binding site [chemical binding]; other site 1045856005109 substrate binding site [chemical binding]; other site 1045856005110 Protein of unknown function (DUF1379); Region: DUF1379; pfam07126 1045856005111 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 1045856005112 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 1045856005113 MOSC domain; Region: MOSC; pfam03473 1045856005114 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1045856005115 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1045856005116 catalytic loop [active] 1045856005117 iron binding site [ion binding]; other site 1045856005118 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 1045856005119 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 1045856005120 Putative RNA methylase family UPF0020; Region: UPF0020; pfam01170 1045856005121 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1045856005122 S-adenosylmethionine binding site [chemical binding]; other site 1045856005123 ABC transporter ATPase component; Reviewed; Region: PRK11147 1045856005124 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1045856005125 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1045856005126 Walker A/P-loop; other site 1045856005127 Walker A/P-loop; other site 1045856005128 ATP binding site [chemical binding]; other site 1045856005129 ATP binding site [chemical binding]; other site 1045856005130 Q-loop/lid; other site 1045856005131 Q-loop/lid; other site 1045856005132 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1045856005133 ABC transporter signature motif; other site 1045856005134 Walker B; other site 1045856005135 D-loop; other site 1045856005136 ABC transporter; Region: ABC_tran_2; pfam12848 1045856005137 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1045856005138 paraquat-inducible membrane protein A; Provisional; Region: PRK15103 1045856005139 Paraquat-inducible protein A; Region: PqiA; pfam04403 1045856005140 Paraquat-inducible protein A; Region: PqiA; pfam04403 1045856005141 paraquat-inducible protein B; Provisional; Region: PRK10807 1045856005142 mce related protein; Region: MCE; pfam02470 1045856005143 mce related protein; Region: MCE; pfam02470 1045856005144 mce related protein; Region: MCE; pfam02470 1045856005145 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009 1045856005146 Protein of unknown function (DUF330); Region: DUF330; pfam03886 1045856005147 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 1045856005148 active site 1 [active] 1045856005149 dimer interface [polypeptide binding]; other site 1045856005150 active site 2 [active] 1045856005151 Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067 1045856005152 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1045856005153 Ter macrodomain organizer matS-binding protein; Provisional; Region: PRK05097 1045856005154 outer membrane protein A; Reviewed; Region: PRK10808 1045856005155 OmpA-like transmembrane domain; Region: OmpA_membrane; pfam01389 1045856005156 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1045856005157 ligand binding site [chemical binding]; other site 1045856005158 SOS cell division inhibitor; Provisional; Region: PRK10595 1045856005159 TfoX N-terminal domain; Region: TfoX_N; pfam04993 1045856005160 TfoX C-terminal domain; Region: TfoX_C; pfam04994 1045856005161 TIGR01666 family membrane protein; Region: YCCS 1045856005162 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 1045856005163 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1045856005164 Predicted membrane protein [Function unknown]; Region: COG3304 1045856005165 Domain of unknown function (DUF307); Region: DUF307; pfam03733 1045856005166 Domain of unknown function (DUF307); Region: DUF307; pfam03733 1045856005167 DNA helicase IV; Provisional; Region: helD; PRK11054 1045856005168 DNA helicase IV / RNA helicase N terminal; Region: Nucleolin_N; pfam12462 1045856005169 Part of AAA domain; Region: AAA_19; pfam13245 1045856005170 Family description; Region: UvrD_C_2; pfam13538 1045856005171 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 1045856005172 active site 1045856005173 dimer interfaces [polypeptide binding]; other site 1045856005174 catalytic residues [active] 1045856005175 hypothetical protein; Provisional; Region: PRK03641 1045856005176 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3110 1045856005177 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 1045856005178 heat shock protein HspQ; Provisional; Region: PRK14129 1045856005179 23S rRNA m(5)C1962 methyltransferase; Provisional; Region: PRK15128 1045856005180 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 1045856005181 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 1045856005182 putative RNA binding site [nucleotide binding]; other site 1045856005183 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1045856005184 S-adenosylmethionine binding site [chemical binding]; other site 1045856005185 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1045856005186 substrate binding site [chemical binding]; other site 1045856005187 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1045856005188 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1045856005189 acylphosphatase; Provisional; Region: PRK14426 1045856005190 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920 1045856005191 sulfur transfer protein TusE; Provisional; Region: PRK11508 1045856005192 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 1045856005193 YccA-like proteins; Region: YccA_like; cd10433 1045856005194 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 1045856005195 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1045856005196 peptide binding site [polypeptide binding]; other site 1045856005197 Methyltransferase domain; Region: Methyltransf_27; pfam13708 1045856005198 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 1045856005199 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 1045856005200 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 1045856005201 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4253 1045856005202 type VI secretion system lysozyme-like protein; Region: VI_zyme; TIGR03357 1045856005203 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3515 1045856005204 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 1045856005205 ImpA domain protein; Region: DUF3702; pfam12486 1045856005206 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1045856005207 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 1045856005208 FMN-binding pocket [chemical binding]; other site 1045856005209 flavin binding motif; other site 1045856005210 phosphate binding motif [ion binding]; other site 1045856005211 beta-alpha-beta structure motif; other site 1045856005212 NAD binding pocket [chemical binding]; other site 1045856005213 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1045856005214 catalytic loop [active] 1045856005215 iron binding site [ion binding]; other site 1045856005216 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1045856005217 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 1045856005218 [2Fe-2S] cluster binding site [ion binding]; other site 1045856005219 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1045856005220 hydrophobic ligand binding site; other site 1045856005221 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1045856005222 FAD binding domain; Region: FAD_binding_3; pfam01494 1045856005223 OHCU decarboxylase; Region: UraD_2; TIGR03180 1045856005224 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 1045856005225 active site 1045856005226 homotetramer interface [polypeptide binding]; other site 1045856005227 guanine deaminase; Provisional; Region: PRK09228 1045856005228 Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303 1045856005229 active site 1045856005230 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily; solute-binding domain; Region: SLC-NCS1sbd_u1; cd11555 1045856005231 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 1045856005232 Na binding site [ion binding]; other site 1045856005233 putative substrate binding site [chemical binding]; other site 1045856005234 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1045856005235 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1045856005236 DNA-binding site [nucleotide binding]; DNA binding site 1045856005237 FCD domain; Region: FCD; pfam07729 1045856005238 Hydantoin racemase [Amino acid transport and metabolism]; Region: COG4126 1045856005239 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 1045856005240 Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977 1045856005241 active site 1045856005242 catalytic site [active] 1045856005243 tetramer interface [polypeptide binding]; other site 1045856005244 Protein of unknown function (DUF3225); Region: DUF3225; pfam11533 1045856005245 amidase; Provisional; Region: PRK09201 1045856005246 Amidase; Region: Amidase; pfam01425 1045856005247 Protein of unknown function (DUF4089); Region: DUF4089; pfam13318 1045856005248 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 1045856005249 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 1045856005250 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1045856005251 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1045856005252 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 1045856005253 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1045856005254 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1045856005255 substrate binding pocket [chemical binding]; other site 1045856005256 membrane-bound complex binding site; other site 1045856005257 hinge residues; other site 1045856005258 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1045856005259 dimer interface [polypeptide binding]; other site 1045856005260 conserved gate region; other site 1045856005261 putative PBP binding loops; other site 1045856005262 ABC-ATPase subunit interface; other site 1045856005263 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1045856005264 dimer interface [polypeptide binding]; other site 1045856005265 conserved gate region; other site 1045856005266 putative PBP binding loops; other site 1045856005267 ABC-ATPase subunit interface; other site 1045856005268 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1045856005269 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1045856005270 Walker A/P-loop; other site 1045856005271 ATP binding site [chemical binding]; other site 1045856005272 Q-loop/lid; other site 1045856005273 ABC transporter signature motif; other site 1045856005274 Walker B; other site 1045856005275 D-loop; other site 1045856005276 H-loop/switch region; other site 1045856005277 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 1045856005278 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1045856005279 catalytic residue [active] 1045856005280 allantoate amidohydrolase; Reviewed; Region: PRK09290 1045856005281 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 1045856005282 active site 1045856005283 metal binding site [ion binding]; metal-binding site 1045856005284 dimer interface [polypeptide binding]; other site 1045856005285 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1045856005286 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1045856005287 Walker A/P-loop; other site 1045856005288 ATP binding site [chemical binding]; other site 1045856005289 Q-loop/lid; other site 1045856005290 ABC transporter signature motif; other site 1045856005291 Walker B; other site 1045856005292 D-loop; other site 1045856005293 H-loop/switch region; other site 1045856005294 TOBE domain; Region: TOBE_2; pfam08402 1045856005295 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 1045856005296 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1045856005297 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1045856005298 dimer interface [polypeptide binding]; other site 1045856005299 conserved gate region; other site 1045856005300 ABC-ATPase subunit interface; other site 1045856005301 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1045856005302 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1045856005303 dimer interface [polypeptide binding]; other site 1045856005304 conserved gate region; other site 1045856005305 putative PBP binding loops; other site 1045856005306 ABC-ATPase subunit interface; other site 1045856005307 Arabinogalactan endo-1,4-beta-galactosidase [Carbohydrate transport and metabolism]; Region: COG3867 1045856005308 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 1045856005309 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 1045856005310 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 1045856005311 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 1045856005312 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1045856005313 active site turn [active] 1045856005314 phosphorylation site [posttranslational modification] 1045856005315 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 1045856005316 trimer interface; other site 1045856005317 sugar binding site [chemical binding]; other site 1045856005318 lac repressor; Reviewed; Region: lacI; PRK09526 1045856005319 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1045856005320 DNA binding site [nucleotide binding] 1045856005321 domain linker motif; other site 1045856005322 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 1045856005323 ligand binding site [chemical binding]; other site 1045856005324 dimerization interface (open form) [polypeptide binding]; other site 1045856005325 dimerization interface (closed form) [polypeptide binding]; other site 1045856005326 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 1045856005327 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1045856005328 Divalent cation transporter; Region: MgtE; pfam01769 1045856005329 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1045856005330 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1045856005331 short chain dehydrogenase; Provisional; Region: PRK06500 1045856005332 classical (c) SDRs; Region: SDR_c; cd05233 1045856005333 NAD(P) binding site [chemical binding]; other site 1045856005334 active site 1045856005335 Predicted transcriptional regulators [Transcription]; Region: COG1733 1045856005336 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1045856005337 glucose-1-phosphatase/inositol phosphatase; Provisional; Region: PRK10173 1045856005338 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 1045856005339 catalytic core [active] 1045856005340 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 1045856005341 hypothetical protein; Provisional; Region: PRK10174 1045856005342 NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767 1045856005343 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1045856005344 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1045856005345 EamA-like transporter family; Region: EamA; pfam00892 1045856005346 EamA-like transporter family; Region: EamA; pfam00892 1045856005347 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 1045856005348 pyrimidine utilization flavin reductase protein F; Region: RutF; TIGR03615 1045856005349 Nitroreductase-like family 5. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148 1045856005350 putative FMN binding site [chemical binding]; other site 1045856005351 pyrimidine utilization protein D; Region: RutD; TIGR03611 1045856005352 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1045856005353 homotrimer interaction site [polypeptide binding]; other site 1045856005354 putative active site [active] 1045856005355 Isochorismatase family; Region: Isochorismatase; pfam00857 1045856005356 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1045856005357 catalytic triad [active] 1045856005358 conserved cis-peptide bond; other site 1045856005359 pyrimidine utilization protein A; Region: RutA; TIGR03612 1045856005360 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 1045856005361 active site 1045856005362 dimer interface [polypeptide binding]; other site 1045856005363 non-prolyl cis peptide bond; other site 1045856005364 insertion regions; other site 1045856005365 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1045856005366 HTH-type transcriptional regulator RutR; Provisional; Region: PRK15008 1045856005367 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1045856005368 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 1045856005369 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3755 1045856005370 trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: putA; PRK11809 1045856005371 Predicted transcriptional regulator [Transcription]; Region: COG3905 1045856005372 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 1045856005373 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 1045856005374 Glutamate binding site [chemical binding]; other site 1045856005375 NAD binding site [chemical binding]; other site 1045856005376 catalytic residues [active] 1045856005377 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 1045856005378 Na binding site [ion binding]; other site 1045856005379 Protein of unknown function (DUF3574); Region: DUF3574; pfam12098 1045856005380 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 1045856005381 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1045856005382 Nucleoside recognition; Region: Gate; pfam07670 1045856005383 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1045856005384 FTR1 family protein; Region: TIGR00145 1045856005385 inactive ferrous ion transporter periplasmic protein EfeO; Provisional; Region: PRK10378 1045856005386 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 1045856005387 Imelysin; Region: Peptidase_M75; pfam09375 1045856005388 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 1045856005389 Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837 1045856005390 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1045856005391 hypothetical protein; Provisional; Region: PRK10536 1045856005392 Isochorismatase family; Region: Isochorismatase; pfam00857 1045856005393 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 1045856005394 catalytic triad [active] 1045856005395 dimer interface [polypeptide binding]; other site 1045856005396 conserved cis-peptide bond; other site 1045856005397 Pirin-related protein [General function prediction only]; Region: COG1741 1045856005398 Pirin; Region: Pirin; pfam02678 1045856005399 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 1045856005400 LysR family transcriptional regulator; Provisional; Region: PRK14997 1045856005401 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1045856005402 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473 1045856005403 putative effector binding pocket; other site 1045856005404 putative dimerization interface [polypeptide binding]; other site 1045856005405 bifunctional glyoxylate/hydroxypyruvate reductase A; Provisional; Region: ghrA; PRK15469 1045856005406 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 1045856005407 putative ligand binding site [chemical binding]; other site 1045856005408 NAD binding site [chemical binding]; other site 1045856005409 dimerization interface [polypeptide binding]; other site 1045856005410 catalytic site [active] 1045856005411 putative hydrolase; Validated; Region: PRK09248 1045856005412 Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437 1045856005413 active site 1045856005414 Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381 1045856005415 Protein of unknown function (DUF1097); Region: DUF1097; pfam06496 1045856005416 curli production assembly/transport protein CsgG; Provisional; Region: PRK15184 1045856005417 curli assembly protein CsgF; Provisional; Region: PRK10050 1045856005418 DNA-binding transcriptional regulator CsgD; Provisional; Region: PRK10100 1045856005419 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1045856005420 DNA binding residues [nucleotide binding] 1045856005421 dimerization interface [polypeptide binding]; other site 1045856005422 curlin minor subunit CsgB; Provisional; Region: csgB; PRK10101 1045856005423 Curlin associated repeat; Region: Curlin_rpt; pfam07012 1045856005424 major curlin subunit; Provisional; Region: csgA; PRK10051 1045856005425 Thin aggregative fimbriae synthesis protein; Region: Tafi-CsgC; cl11667 1045856005426 Fimbrial protein; Region: Fimbrial; cl01416 1045856005427 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 1045856005428 putative ADP-ribose binding site [chemical binding]; other site 1045856005429 putative active site [active] 1045856005430 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 1045856005431 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1045856005432 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 1045856005433 Periplasmic glucan biosynthesis protein, MdoG; Region: MdoG; pfam04349 1045856005434 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1045856005435 Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191 1045856005436 Ligand binding site; other site 1045856005437 DXD motif; other site 1045856005438 lipoprotein; Provisional; Region: PRK10175 1045856005439 secY/secA suppressor protein; Provisional; Region: PRK11467 1045856005440 drug efflux system protein MdtG; Provisional; Region: PRK09874 1045856005441 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1045856005442 putative substrate translocation pore; other site 1045856005443 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 1045856005444 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1045856005445 putative acyl-acceptor binding pocket; other site 1045856005446 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 1045856005447 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 1045856005448 active site residue [active] 1045856005449 hypothetical protein; Provisional; Region: PRK03757 1045856005450 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 1045856005451 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 1045856005452 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1045856005453 biofilm formation regulatory protein BssS; Reviewed; Region: bssS; PRK12301 1045856005454 DNA damage-inducible protein I; Provisional; Region: PRK10597 1045856005455 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 1045856005456 active site 1045856005457 substrate binding pocket [chemical binding]; other site 1045856005458 dimer interface [polypeptide binding]; other site 1045856005459 lipoprotein; Provisional; Region: PRK10598 1045856005460 multidrug resistance protein MdtH; Provisional; Region: PRK11646 1045856005461 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1045856005462 putative substrate translocation pore; other site 1045856005463 ribosomal-protein-S5-alanine N-acetyltransferase; Provisional; Region: PRK10809 1045856005464 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1045856005465 hypothetical protein; Provisional; Region: PRK11239 1045856005466 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3132 1045856005467 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1045856005468 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1045856005469 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 1045856005470 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 1045856005471 flagella synthesis chaperone protein FlgN; Provisional; Region: PRK15459 1045856005472 anti-sigma28 factor FlgM; Provisional; Region: PRK10810 1045856005473 flagellar basal body P-ring biosynthesis protein FlgA; Reviewed; Region: flgA; PRK07018 1045856005474 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 1045856005475 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 1045856005476 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 1045856005477 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 1045856005478 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 1045856005479 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1045856005480 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1045856005481 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655 1045856005482 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 1045856005483 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 1045856005484 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 1045856005485 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1045856005486 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 1045856005487 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1045856005488 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgF; COG4787 1045856005489 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1045856005490 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 1045856005491 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 1045856005492 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1045856005493 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1045856005494 Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063 1045856005495 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 1045856005496 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 1045856005497 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 1045856005498 flagellar rod assembly protein/muramidase FlgJ; Validated; Region: flgJ; PRK05684 1045856005499 Rod binding protein [Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3951 1045856005500 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 1045856005501 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK08147 1045856005502 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1045856005503 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1045856005504 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08027 1045856005505 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1045856005506 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1045856005507 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1045856005508 putative substrate translocation pore; other site 1045856005509 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1045856005510 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1045856005511 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1045856005512 putative effector binding pocket; other site 1045856005513 dimerization interface [polypeptide binding]; other site 1045856005514 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 1045856005515 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 1045856005516 homodimer interface [polypeptide binding]; other site 1045856005517 oligonucleotide binding site [chemical binding]; other site 1045856005518 Polyribonucleotide phosphorylase C terminal; Region: PNPase_C; pfam12111 1045856005519 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 1045856005520 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1045856005521 RNA binding surface [nucleotide binding]; other site 1045856005522 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1045856005523 active site 1045856005524 Maf-like protein; Region: Maf; pfam02545 1045856005525 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1045856005526 active site 1045856005527 dimer interface [polypeptide binding]; other site 1045856005528 hypothetical protein; Provisional; Region: PRK11193 1045856005529 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 1045856005530 putative phosphate acyltransferase; Provisional; Region: PRK05331 1045856005531 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 1045856005532 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1045856005533 dimer interface [polypeptide binding]; other site 1045856005534 active site 1045856005535 CoA binding pocket [chemical binding]; other site 1045856005536 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1045856005537 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1045856005538 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1045856005539 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1045856005540 NAD(P) binding site [chemical binding]; other site 1045856005541 homotetramer interface [polypeptide binding]; other site 1045856005542 homodimer interface [polypeptide binding]; other site 1045856005543 active site 1045856005544 acyl carrier protein; Provisional; Region: acpP; PRK00982 1045856005545 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 1045856005546 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1045856005547 dimer interface [polypeptide binding]; other site 1045856005548 active site 1045856005549 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1045856005550 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 1045856005551 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1045856005552 catalytic residue [active] 1045856005553 conserved hypothetical protein, YceG family; Region: TIGR00247 1045856005554 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 1045856005555 dimerization interface [polypeptide binding]; other site 1045856005556 thymidylate kinase; Validated; Region: tmk; PRK00698 1045856005557 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1045856005558 TMP-binding site; other site 1045856005559 ATP-binding site [chemical binding]; other site 1045856005560 DNA polymerase III subunit delta'; Validated; Region: PRK07993 1045856005561 DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115 1045856005562 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1045856005563 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 1045856005564 active site 1045856005565 PTS system glucose-specific transporter subunits IIBC; Provisional; Region: PRK11089 1045856005566 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1045856005567 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1045856005568 active site turn [active] 1045856005569 phosphorylation site [posttranslational modification] 1045856005570 ferric-rhodotorulic acid outer membrane transporter; Provisional; Region: PRK10003 1045856005571 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1045856005572 N-terminal plug; other site 1045856005573 ligand-binding site [chemical binding]; other site 1045856005574 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 1045856005575 nucleotide binding site/active site [active] 1045856005576 HIT family signature motif; other site 1045856005577 catalytic residue [active] 1045856005578 Predicted periplasmic lipoprotein [General function prediction only]; Region: COG5633 1045856005579 Putative periplasmic lipoprotein; Region: DUF1425; cd09030 1045856005580 putative dimer interface [polypeptide binding]; other site 1045856005581 Collagen-binding surface adhesin SpaP (antigen I/II family) [General function prediction only]; Region: FlgN; COG3417 1045856005582 thiamine kinase; Region: ycfN_thiK; TIGR02721 1045856005583 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1045856005584 active site 1045856005585 substrate binding site [chemical binding]; other site 1045856005586 ATP binding site [chemical binding]; other site 1045856005587 beta-hexosaminidase; Provisional; Region: PRK05337 1045856005588 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1045856005589 hypothetical protein; Provisional; Region: PRK04940 1045856005590 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1045856005591 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1045856005592 hypothetical protein; Provisional; Region: PRK11280 1045856005593 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1045856005594 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1045856005595 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1045856005596 L,D-transpeptidase; Provisional; Region: PRK10190 1045856005597 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1045856005598 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1045856005599 transcription-repair coupling factor; Provisional; Region: PRK10689 1045856005600 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 1045856005601 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1045856005602 ATP binding site [chemical binding]; other site 1045856005603 putative Mg++ binding site [ion binding]; other site 1045856005604 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1045856005605 nucleotide binding region [chemical binding]; other site 1045856005606 ATP-binding site [chemical binding]; other site 1045856005607 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 1045856005608 Predicted membrane protein [Function unknown]; Region: COG4763 1045856005609 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1045856005610 outer membrane-specific lipoprotein transporter subunit LolC; Provisional; Region: PRK10814 1045856005611 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1045856005612 FtsX-like permease family; Region: FtsX; pfam02687 1045856005613 lipoprotein transporter ATP-binding subunit; Provisional; Region: lolD; PRK11629 1045856005614 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1045856005615 Walker A/P-loop; other site 1045856005616 ATP binding site [chemical binding]; other site 1045856005617 Q-loop/lid; other site 1045856005618 ABC transporter signature motif; other site 1045856005619 Walker B; other site 1045856005620 D-loop; other site 1045856005621 H-loop/switch region; other site 1045856005622 outer membrane-specific lipoprotein transporter subunit LolE; Provisional; Region: PRK11146 1045856005623 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1045856005624 FtsX-like permease family; Region: FtsX; pfam02687 1045856005625 fructokinase; Reviewed; Region: PRK09557 1045856005626 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1045856005627 nucleotide binding site [chemical binding]; other site 1045856005628 NAD-dependent deacetylase; Provisional; Region: PRK00481 1045856005629 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 1045856005630 NAD+ binding site [chemical binding]; other site 1045856005631 substrate binding site [chemical binding]; other site 1045856005632 Zn binding site [ion binding]; other site 1045856005633 Cache domain; Region: Cache_1; pfam02743 1045856005634 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1045856005635 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1045856005636 dimer interface [polypeptide binding]; other site 1045856005637 putative CheW interface [polypeptide binding]; other site 1045856005638 Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434 1045856005639 EAL domain; Region: EAL; pfam00563 1045856005640 spermidine/putrescine ABC transporter periplasmic substrate-binding protein; Reviewed; Region: potD; PRK09501 1045856005641 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 1045856005642 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1045856005643 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1045856005644 dimer interface [polypeptide binding]; other site 1045856005645 conserved gate region; other site 1045856005646 putative PBP binding loops; other site 1045856005647 ABC-ATPase subunit interface; other site 1045856005648 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1045856005649 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1045856005650 dimer interface [polypeptide binding]; other site 1045856005651 conserved gate region; other site 1045856005652 putative PBP binding loops; other site 1045856005653 ABC-ATPase subunit interface; other site 1045856005654 putrescine/spermidine ABC transporter ATPase protein; Reviewed; Region: potA; PRK09452 1045856005655 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1045856005656 Walker A/P-loop; other site 1045856005657 ATP binding site [chemical binding]; other site 1045856005658 Q-loop/lid; other site 1045856005659 ABC transporter signature motif; other site 1045856005660 Walker B; other site 1045856005661 D-loop; other site 1045856005662 H-loop/switch region; other site 1045856005663 TOBE domain; Region: TOBE_2; pfam08402 1045856005664 Di- and tripeptidases [Amino acid transport and metabolism]; Region: PepD; COG2195 1045856005665 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 1045856005666 metal binding site [ion binding]; metal-binding site 1045856005667 dimer interface [polypeptide binding]; other site 1045856005668 Uncharacterized conserved protein [Function unknown]; Region: COG2850 1045856005669 sensor protein PhoQ; Provisional; Region: PRK10815 1045856005670 PhoQ Sensor; Region: PhoQ_Sensor; pfam08918 1045856005671 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 1045856005672 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1045856005673 ATP binding site [chemical binding]; other site 1045856005674 Mg2+ binding site [ion binding]; other site 1045856005675 G-X-G motif; other site 1045856005676 DNA-binding transcriptional regulator PhoP; Provisional; Region: PRK10816 1045856005677 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1045856005678 active site 1045856005679 phosphorylation site [posttranslational modification] 1045856005680 intermolecular recognition site; other site 1045856005681 dimerization interface [polypeptide binding]; other site 1045856005682 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1045856005683 DNA binding site [nucleotide binding] 1045856005684 adenylosuccinate lyase; Provisional; Region: PRK09285 1045856005685 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 1045856005686 tetramer interface [polypeptide binding]; other site 1045856005687 active site 1045856005688 putative lysogenization regulator; Reviewed; Region: PRK00218 1045856005689 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 1045856005690 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Region: trmU; TIGR00420 1045856005691 Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675 1045856005692 nudix motif; other site 1045856005693 Pseudouridine synthase, Escherichia coli RluE; Region: PseudoU_synth_RluE; cd02566 1045856005694 pseudouridine synthase; Region: TIGR00093 1045856005695 probable active site [active] 1045856005696 isocitrate dehydrogenase; Validated; Region: PRK07362 1045856005697 isocitrate dehydrogenase; Reviewed; Region: PRK07006 1045856005698 Glycosyl hydrolase family 26; Region: Glyco_hydro_26; pfam02156 1045856005699 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 1045856005700 Protein of unknown function (DUF2543); Region: DUF2543; pfam10820 1045856005701 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1045856005702 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 1045856005703 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 1045856005704 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1045856005705 Cache domain; Region: Cache_1; pfam02743 1045856005706 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1045856005707 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1045856005708 metal binding site [ion binding]; metal-binding site 1045856005709 active site 1045856005710 I-site; other site 1045856005711 hypothetical protein; Provisional; Region: PRK10457 1045856005712 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1045856005713 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1045856005714 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1045856005715 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1045856005716 metal binding site [ion binding]; metal-binding site 1045856005717 active site 1045856005718 I-site; other site 1045856005719 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1045856005720 Uncharacterized conserved protein [Function unknown]; Region: COG3189 1045856005721 hypothetical protein; Validated; Region: PRK06186 1045856005722 conserved cys residue [active] 1045856005723 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 1045856005724 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1045856005725 putative substrate translocation pore; other site 1045856005726 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1045856005727 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1045856005728 Predicted membrane protein [Function unknown]; Region: COG2707 1045856005729 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 1045856005730 putative deacylase active site [active] 1045856005731 hypothetical protein; Provisional; Region: PRK05325 1045856005732 PrkA family serine protein kinase; Provisional; Region: PRK15455 1045856005733 AAA ATPase domain; Region: AAA_16; pfam13191 1045856005734 Walker A motif; other site 1045856005735 ATP binding site [chemical binding]; other site 1045856005736 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 1045856005737 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 1045856005738 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1045856005739 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1045856005740 active site 1045856005741 catalytic tetrad [active] 1045856005742 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 1045856005743 active site 1045856005744 phosphate binding residues; other site 1045856005745 catalytic residues [active] 1045856005746 glyceraldehyde-3-phosphate dehydrogenase A; Provisional; Region: gapA; PRK15425 1045856005747 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1045856005748 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1045856005749 methionine sulfoxide reductase B; Provisional; Region: PRK00222 1045856005750 SelR domain; Region: SelR; pfam01641 1045856005751 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3139 1045856005752 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 1045856005753 Glyco_18 domain; Region: Glyco_18; smart00636 1045856005754 active site 1045856005755 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 1045856005756 Isochorismatase family; Region: Isochorismatase; pfam00857 1045856005757 catalytic triad [active] 1045856005758 metal binding site [ion binding]; metal-binding site 1045856005759 conserved cis-peptide bond; other site 1045856005760 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 1045856005761 active site 1045856005762 homodimer interface [polypeptide binding]; other site 1045856005763 protease 4; Provisional; Region: PRK10949 1045856005764 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 1045856005765 tandem repeat interface [polypeptide binding]; other site 1045856005766 oligomer interface [polypeptide binding]; other site 1045856005767 active site residues [active] 1045856005768 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_1; cd07019 1045856005769 tandem repeat interface [polypeptide binding]; other site 1045856005770 oligomer interface [polypeptide binding]; other site 1045856005771 active site residues [active] 1045856005772 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 1045856005773 putative FMN binding site [chemical binding]; other site 1045856005774 selenophosphate synthetase; Provisional; Region: PRK00943 1045856005775 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 1045856005776 dimerization interface [polypeptide binding]; other site 1045856005777 putative ATP binding site [chemical binding]; other site 1045856005778 DNA topoisomerase III; Provisional; Region: PRK07726 1045856005779 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 1045856005780 active site 1045856005781 putative interdomain interaction site [polypeptide binding]; other site 1045856005782 putative metal-binding site [ion binding]; other site 1045856005783 putative nucleotide binding site [chemical binding]; other site 1045856005784 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1045856005785 domain I; other site 1045856005786 DNA binding groove [nucleotide binding] 1045856005787 phosphate binding site [ion binding]; other site 1045856005788 domain II; other site 1045856005789 domain III; other site 1045856005790 nucleotide binding site [chemical binding]; other site 1045856005791 catalytic site [active] 1045856005792 domain IV; other site 1045856005793 glutamate dehydrogenase; Provisional; Region: PRK09414 1045856005794 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1045856005795 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 1045856005796 NAD(P) binding site [chemical binding]; other site 1045856005797 Protein of unknown function (DUF1496); Region: DUF1496; pfam07383 1045856005798 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 1045856005799 active site 1045856005800 8-oxo-dGMP binding site [chemical binding]; other site 1045856005801 nudix motif; other site 1045856005802 metal binding site [ion binding]; metal-binding site 1045856005803 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1045856005804 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1045856005805 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 1045856005806 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1045856005807 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1045856005808 active site residue [active] 1045856005809 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1045856005810 active site residue [active] 1045856005811 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4136 1045856005812 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1045856005813 Walker A/P-loop; other site 1045856005814 ATP binding site [chemical binding]; other site 1045856005815 Q-loop/lid; other site 1045856005816 ABC transporter signature motif; other site 1045856005817 Walker B; other site 1045856005818 D-loop; other site 1045856005819 H-loop/switch region; other site 1045856005820 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4135 1045856005821 hypothetical protein; Provisional; Region: PRK11622 1045856005822 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4134 1045856005823 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1045856005824 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1045856005825 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 1045856005826 putative catalytic site [active] 1045856005827 putative phosphate binding site [ion binding]; other site 1045856005828 active site 1045856005829 metal binding site A [ion binding]; metal-binding site 1045856005830 DNA binding site [nucleotide binding] 1045856005831 putative AP binding site [nucleotide binding]; other site 1045856005832 putative metal binding site B [ion binding]; other site 1045856005833 bifunctional succinylornithine transaminase/acetylornithine transaminase; Provisional; Region: PRK12381 1045856005834 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1045856005835 inhibitor-cofactor binding pocket; inhibition site 1045856005836 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1045856005837 catalytic residue [active] 1045856005838 arginine succinyltransferase; Provisional; Region: PRK10456 1045856005839 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 1045856005840 succinylglutamic semialdehyde dehydrogenase; Reviewed; Region: astD; PRK09457 1045856005841 N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095 1045856005842 NAD(P) binding site [chemical binding]; other site 1045856005843 catalytic residues [active] 1045856005844 succinylarginine dihydrolase; Provisional; Region: PRK13281 1045856005845 succinylglutamate desuccinylase; Provisional; Region: PRK05324 1045856005846 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 1045856005847 active site 1045856005848 Zn binding site [ion binding]; other site 1045856005849 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 1045856005850 dimer interface [polypeptide binding]; other site 1045856005851 hypothetical protein; Provisional; Region: PRK11396 1045856005852 nucleotide excision repair endonuclease; Provisional; Region: PRK10545 1045856005853 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1045856005854 GIY-YIG motif/motif A; other site 1045856005855 active site 1045856005856 catalytic site [active] 1045856005857 putative DNA binding site [nucleotide binding]; other site 1045856005858 metal binding site [ion binding]; metal-binding site 1045856005859 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 1045856005860 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1045856005861 homodimer interface [polypeptide binding]; other site 1045856005862 NAD binding pocket [chemical binding]; other site 1045856005863 ATP binding pocket [chemical binding]; other site 1045856005864 Mg binding site [ion binding]; other site 1045856005865 active-site loop [active] 1045856005866 DNA-binding transcriptional activator OsmE; Provisional; Region: PRK11251 1045856005867 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 1045856005868 active site 1045856005869 P-loop; other site 1045856005870 phosphorylation site [posttranslational modification] 1045856005871 PTS system N,N'-diacetylchitobiose-specific transporter subunit IIC; Provisional; Region: PRK10297 1045856005872 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1045856005873 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 1045856005874 methionine cluster; other site 1045856005875 active site 1045856005876 phosphorylation site [posttranslational modification] 1045856005877 metal binding site [ion binding]; metal-binding site 1045856005878 DNA-binding transcriptional regulator ChbR; Provisional; Region: PRK10296 1045856005879 Cupin domain; Region: Cupin_2; pfam07883 1045856005880 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1045856005881 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 1045856005882 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 1045856005883 NAD binding site [chemical binding]; other site 1045856005884 sugar binding site [chemical binding]; other site 1045856005885 divalent metal binding site [ion binding]; other site 1045856005886 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1045856005887 dimer interface [polypeptide binding]; other site 1045856005888 Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803 1045856005889 putative active site [active] 1045856005890 YdjC motif; other site 1045856005891 Mg binding site [ion binding]; other site 1045856005892 putative homodimer interface [polypeptide binding]; other site 1045856005893 hydroperoxidase II; Provisional; Region: katE; PRK11249 1045856005894 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 1045856005895 tetramer interface [polypeptide binding]; other site 1045856005896 heme binding pocket [chemical binding]; other site 1045856005897 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 1045856005898 domain interactions; other site 1045856005899 cell division modulator; Provisional; Region: PRK10113 1045856005900 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 1045856005901 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1045856005902 inner membrane protein; Provisional; Region: PRK11648 1045856005903 2-deoxy-D-gluconate 3-dehydrogenase; Validated; Region: PRK08993 1045856005904 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 1045856005905 NADP binding site [chemical binding]; other site 1045856005906 homodimer interface [polypeptide binding]; other site 1045856005907 active site 1045856005908 2-deoxyglucose-6-phosphatase; Provisional; Region: PRK10826 1045856005909 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1045856005910 active site 1045856005911 motif I; other site 1045856005912 motif II; other site 1045856005913 YniB-like protein; Region: YniB; pfam14002 1045856005914 Phosphotransferase enzyme family; Region: APH; pfam01636 1045856005915 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1045856005916 active site 1045856005917 ATP binding site [chemical binding]; other site 1045856005918 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1045856005919 active site 1045856005920 ATP binding site [chemical binding]; other site 1045856005921 Protein of unknown function (DUF2622); Region: DUF2622; pfam11080 1045856005922 6-phosphofructokinase 2; Provisional; Region: PRK10294 1045856005923 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1045856005924 putative substrate binding site [chemical binding]; other site 1045856005925 putative ATP binding site [chemical binding]; other site 1045856005926 Putative salt-induced outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG3137 1045856005927 Protein of unknown function (DUF1471); Region: DUF1471; cl11507 1045856005928 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 1045856005929 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 1045856005930 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 1045856005931 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1045856005932 active site 1045856005933 dimer interface [polypeptide binding]; other site 1045856005934 motif 1; other site 1045856005935 motif 2; other site 1045856005936 motif 3; other site 1045856005937 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1045856005938 anticodon binding site; other site 1045856005939 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 1045856005940 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1045856005941 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1045856005942 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 1045856005943 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1045856005944 23S rRNA binding site [nucleotide binding]; other site 1045856005945 L21 binding site [polypeptide binding]; other site 1045856005946 L13 binding site [polypeptide binding]; other site 1045856005947 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1045856005948 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1045856005949 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1045856005950 dimer interface [polypeptide binding]; other site 1045856005951 motif 1; other site 1045856005952 active site 1045856005953 motif 2; other site 1045856005954 motif 3; other site 1045856005955 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1045856005956 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1045856005957 putative tRNA-binding site [nucleotide binding]; other site 1045856005958 B3/4 domain; Region: B3_4; pfam03483 1045856005959 tRNA synthetase B5 domain; Region: B5; smart00874 1045856005960 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1045856005961 dimer interface [polypeptide binding]; other site 1045856005962 motif 1; other site 1045856005963 motif 3; other site 1045856005964 motif 2; other site 1045856005965 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 1045856005966 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1045856005967 IHF dimer interface [polypeptide binding]; other site 1045856005968 IHF - DNA interface [nucleotide binding]; other site 1045856005969 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1045856005970 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1045856005971 ABC-ATPase subunit interface; other site 1045856005972 dimer interface [polypeptide binding]; other site 1045856005973 putative PBP binding regions; other site 1045856005974 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 1045856005975 catalytic residues [active] 1045856005976 dimer interface [polypeptide binding]; other site 1045856005977 vitamin B12-transporter ATPase; Provisional; Region: PRK03695 1045856005978 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1045856005979 Walker A/P-loop; other site 1045856005980 ATP binding site [chemical binding]; other site 1045856005981 Q-loop/lid; other site 1045856005982 ABC transporter signature motif; other site 1045856005983 Walker B; other site 1045856005984 D-loop; other site 1045856005985 H-loop/switch region; other site 1045856005986 NlpC/P60 family; Region: NLPC_P60; pfam00877 1045856005987 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290 1045856005988 Uncharacterized conserved protein [Function unknown]; Region: COG0397 1045856005989 hypothetical protein; Validated; Region: PRK00029 1045856005990 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 1045856005991 d-3-hydroxybutyrate dehydrogenase (HBDH), classical (c) SDRs; Region: HBDH_SDR_c; cd08940 1045856005992 NAD binding site [chemical binding]; other site 1045856005993 homotetramer interface [polypeptide binding]; other site 1045856005994 homodimer interface [polypeptide binding]; other site 1045856005995 substrate binding site [chemical binding]; other site 1045856005996 active site 1045856005997 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 1045856005998 putative acyltransferase; Provisional; Region: PRK05790 1045856005999 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1045856006000 dimer interface [polypeptide binding]; other site 1045856006001 active site 1045856006002 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 1045856006003 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 1045856006004 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1045856006005 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1045856006006 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 1045856006007 putative dimerization interface [polypeptide binding]; other site 1045856006008 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 1045856006009 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1045856006010 Walker A/P-loop; other site 1045856006011 ATP binding site [chemical binding]; other site 1045856006012 Q-loop/lid; other site 1045856006013 ABC transporter signature motif; other site 1045856006014 Walker B; other site 1045856006015 D-loop; other site 1045856006016 H-loop/switch region; other site 1045856006017 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1045856006018 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1045856006019 ABC-ATPase subunit interface; other site 1045856006020 dimer interface [polypeptide binding]; other site 1045856006021 putative PBP binding regions; other site 1045856006022 ABC-type hemin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ChuT; COG4558 1045856006023 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1045856006024 intersubunit interface [polypeptide binding]; other site 1045856006025 Putative heme degradation protein [Inorganic ion transport and metabolism]; Region: HemS; COG3720 1045856006026 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 1045856006027 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 1045856006028 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 1045856006029 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1045856006030 N-terminal plug; other site 1045856006031 ligand-binding site [chemical binding]; other site 1045856006032 Hemin uptake protein hemP; Region: hemP; cl10043 1045856006033 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12756 1045856006034 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1045856006035 PEP synthetase regulatory protein; Provisional; Region: PRK05339 1045856006036 putative symporter YagG; Provisional; Region: PRK09669 1045856006037 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 1045856006038 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 1045856006039 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 1045856006040 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 1045856006041 putative inner membrane protein; Provisional; Region: PRK10983 1045856006042 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1045856006043 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1045856006044 FAD binding domain; Region: FAD_binding_4; pfam01565 1045856006045 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1045856006046 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1045856006047 CoenzymeA binding site [chemical binding]; other site 1045856006048 subunit interaction site [polypeptide binding]; other site 1045856006049 PHB binding site; other site 1045856006050 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1045856006051 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 1045856006052 ligand binding site [chemical binding]; other site 1045856006053 flexible hinge region; other site 1045856006054 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 1045856006055 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11832 1045856006056 ligand binding site [chemical binding]; other site 1045856006057 flexible hinge region; other site 1045856006058 Fimbrial protein; Region: Fimbrial; cl01416 1045856006059 fimbrial assembly chaperone SthB; Provisional; Region: PRK15295 1045856006060 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1045856006061 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1045856006062 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 1045856006063 PapC N-terminal domain; Region: PapC_N; pfam13954 1045856006064 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1045856006065 PapC C-terminal domain; Region: PapC_C; pfam13953 1045856006066 baseplate wedge subunit; Provisional; Region: 7; PHA02579 1045856006067 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1045856006068 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1045856006069 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1045856006070 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1045856006071 DNA binding residues [nucleotide binding] 1045856006072 dimerization interface [polypeptide binding]; other site 1045856006073 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 1045856006074 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 1045856006075 [4Fe-4S] binding site [ion binding]; other site 1045856006076 molybdopterin cofactor binding site; other site 1045856006077 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790 1045856006078 molybdopterin cofactor binding site; other site 1045856006079 Biofilm development protein YmgB/AriR; Region: YmgB; pfam10798 1045856006080 Sensors of blue-light using FAD; Region: BLUF; pfam04940 1045856006081 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1045856006082 transcriptional regulator MirA; Provisional; Region: PRK15043 1045856006083 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 1045856006084 DNA binding residues [nucleotide binding] 1045856006085 iron-sulfur cluster assembly scaffold protein; Provisional; Region: sufA; PRK09504 1045856006086 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 1045856006087 putative ABC transporter; Region: ycf24; CHL00085 1045856006088 cysteine desulfurase ATPase component; Reviewed; Region: sufC; PRK09580 1045856006089 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 1045856006090 Walker A/P-loop; other site 1045856006091 ATP binding site [chemical binding]; other site 1045856006092 Q-loop/lid; other site 1045856006093 ABC transporter signature motif; other site 1045856006094 Walker B; other site 1045856006095 D-loop; other site 1045856006096 H-loop/switch region; other site 1045856006097 cysteine desulfurase activator complex subunit SufD; Provisional; Region: PRK10948 1045856006098 FeS assembly protein SufD; Region: sufD; TIGR01981 1045856006099 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1045856006100 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1045856006101 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1045856006102 catalytic residue [active] 1045856006103 cysteine desufuration protein SufE; Provisional; Region: PRK09296 1045856006104 L,D-transpeptidase; Provisional; Region: PRK10260 1045856006105 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1045856006106 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1045856006107 murein lipoprotein; Provisional; Region: PRK15396 1045856006108 pyruvate kinase; Provisional; Region: PRK09206 1045856006109 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 1045856006110 domain interfaces; other site 1045856006111 active site 1045856006112 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 1045856006113 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1045856006114 homodimer interface [polypeptide binding]; other site 1045856006115 substrate-cofactor binding pocket; other site 1045856006116 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1045856006117 catalytic residue [active] 1045856006118 cystathionine beta-synthase; Region: cysta_beta; TIGR01137 1045856006119 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1045856006120 dimer interface [polypeptide binding]; other site 1045856006121 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1045856006122 catalytic residue [active] 1045856006123 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609 1045856006124 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 1045856006125 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1045856006126 Walker A/P-loop; other site 1045856006127 ATP binding site [chemical binding]; other site 1045856006128 Q-loop/lid; other site 1045856006129 ABC transporter signature motif; other site 1045856006130 Walker B; other site 1045856006131 D-loop; other site 1045856006132 H-loop/switch region; other site 1045856006133 NIL domain; Region: NIL; pfam09383 1045856006134 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1045856006135 dimer interface [polypeptide binding]; other site 1045856006136 conserved gate region; other site 1045856006137 putative PBP binding loops; other site 1045856006138 ABC-ATPase subunit interface; other site 1045856006139 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1045856006140 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1045856006141 hypothetical protein; Provisional; Region: PRK10292 1045856006142 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1045856006143 dimer interface [polypeptide binding]; other site 1045856006144 conserved gate region; other site 1045856006145 putative PBP binding loops; other site 1045856006146 ABC-ATPase subunit interface; other site 1045856006147 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1045856006148 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1045856006149 dimer interface [polypeptide binding]; other site 1045856006150 conserved gate region; other site 1045856006151 putative PBP binding loops; other site 1045856006152 ABC-ATPase subunit interface; other site 1045856006153 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1045856006154 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1045856006155 Walker A/P-loop; other site 1045856006156 ATP binding site [chemical binding]; other site 1045856006157 Q-loop/lid; other site 1045856006158 ABC transporter signature motif; other site 1045856006159 Walker B; other site 1045856006160 D-loop; other site 1045856006161 H-loop/switch region; other site 1045856006162 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1045856006163 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1045856006164 substrate binding pocket [chemical binding]; other site 1045856006165 membrane-bound complex binding site; other site 1045856006166 hinge residues; other site 1045856006167 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 1045856006168 dimer interface [polypeptide binding]; other site 1045856006169 phosphorylation site [posttranslational modification] 1045856006170 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1045856006171 ATP binding site [chemical binding]; other site 1045856006172 Mg2+ binding site [ion binding]; other site 1045856006173 G-X-G motif; other site 1045856006174 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 1045856006175 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1045856006176 active site 1045856006177 phosphorylation site [posttranslational modification] 1045856006178 intermolecular recognition site; other site 1045856006179 dimerization interface [polypeptide binding]; other site 1045856006180 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1045856006181 DNA binding residues [nucleotide binding] 1045856006182 dimerization interface [polypeptide binding]; other site 1045856006183 Domain of unknown function (DUF336); Region: DUF336; cl01249 1045856006184 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1045856006185 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 1045856006186 active site clefts [active] 1045856006187 zinc binding site [ion binding]; other site 1045856006188 dimer interface [polypeptide binding]; other site 1045856006189 hypothetical protein; Provisional; Region: PRK09897 1045856006190 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 1045856006191 multidrug efflux protein; Reviewed; Region: PRK01766 1045856006192 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 1045856006193 cation binding site [ion binding]; other site 1045856006194 riboflavin synthase subunit alpha; Provisional; Region: PRK13020 1045856006195 Lumazine binding domain; Region: Lum_binding; pfam00677 1045856006196 Lumazine binding domain; Region: Lum_binding; pfam00677 1045856006197 cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705 1045856006198 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1045856006199 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1045856006200 S-adenosylmethionine binding site [chemical binding]; other site 1045856006201 putative transporter; Provisional; Region: PRK11043 1045856006202 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1045856006203 putative substrate translocation pore; other site 1045856006204 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 1045856006205 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1045856006206 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1045856006207 dimerization interface [polypeptide binding]; other site 1045856006208 DNA-binding transcriptional repressor PurR; Provisional; Region: PRK10703 1045856006209 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1045856006210 DNA binding site [nucleotide binding] 1045856006211 domain linker motif; other site 1045856006212 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 1045856006213 dimerization interface [polypeptide binding]; other site 1045856006214 ligand binding site [chemical binding]; other site 1045856006215 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1045856006216 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1045856006217 putative substrate translocation pore; other site 1045856006218 superoxide dismutase; Provisional; Region: PRK10543 1045856006219 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1045856006220 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1045856006221 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1045856006222 NlpC/P60 family; Region: NLPC_P60; pfam00877 1045856006223 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 1045856006224 putative GSH binding site [chemical binding]; other site 1045856006225 catalytic residues [active] 1045856006226 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 1045856006227 DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134 1045856006228 dimer interface [polypeptide binding]; other site 1045856006229 catalytic site [active] 1045856006230 putative active site [active] 1045856006231 putative substrate binding site [chemical binding]; other site 1045856006232 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1045856006233 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 1045856006234 dimer interface [polypeptide binding]; other site 1045856006235 active site 1045856006236 metal binding site [ion binding]; metal-binding site 1045856006237 glutathione binding site [chemical binding]; other site 1045856006238 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1045856006239 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 1045856006240 FMN binding site [chemical binding]; other site 1045856006241 active site 1045856006242 substrate binding site [chemical binding]; other site 1045856006243 catalytic residue [active] 1045856006244 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1045856006245 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1045856006246 putative metal dependent hydrolase; Provisional; Region: PRK11598 1045856006247 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 1045856006248 Sulfatase; Region: Sulfatase; pfam00884 1045856006249 Predicted Fe-S protein [General function prediction only]; Region: COG3313 1045856006250 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1045856006251 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1045856006252 active site 1045856006253 catalytic tetrad [active] 1045856006254 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 1045856006255 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 1045856006256 E-class dimer interface [polypeptide binding]; other site 1045856006257 P-class dimer interface [polypeptide binding]; other site 1045856006258 active site 1045856006259 Cu2+ binding site [ion binding]; other site 1045856006260 Zn2+ binding site [ion binding]; other site 1045856006261 Fusaric acid resistance protein family; Region: FUSC; pfam04632 1045856006262 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1045856006263 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 1045856006264 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1045856006265 HlyD family secretion protein; Region: HlyD_3; pfam13437 1045856006266 transcriptional regulator SlyA; Provisional; Region: PRK03573 1045856006267 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 1045856006268 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1045856006269 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1045856006270 metal binding site [ion binding]; metal-binding site 1045856006271 active site 1045856006272 I-site; other site 1045856006273 Outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: SlyB; COG3133 1045856006274 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 1045856006275 lysozyme inhibitor; Provisional; Region: PRK11372 1045856006276 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 1045856006277 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 1045856006278 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1045856006279 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 1045856006280 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 1045856006281 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 1045856006282 active site 1045856006283 HIGH motif; other site 1045856006284 dimer interface [polypeptide binding]; other site 1045856006285 KMSKS motif; other site 1045856006286 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1045856006287 RNA binding surface [nucleotide binding]; other site 1045856006288 pyridoxamine kinase; Validated; Region: PRK05756 1045856006289 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 1045856006290 dimer interface [polypeptide binding]; other site 1045856006291 pyridoxal binding site [chemical binding]; other site 1045856006292 ATP binding site [chemical binding]; other site 1045856006293 glutathionine S-transferase; Provisional; Region: PRK10542 1045856006294 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 1045856006295 C-terminal domain interface [polypeptide binding]; other site 1045856006296 GSH binding site (G-site) [chemical binding]; other site 1045856006297 dimer interface [polypeptide binding]; other site 1045856006298 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 1045856006299 N-terminal domain interface [polypeptide binding]; other site 1045856006300 dimer interface [polypeptide binding]; other site 1045856006301 substrate binding pocket (H-site) [chemical binding]; other site 1045856006302 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 1045856006303 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1045856006304 putative substrate translocation pore; other site 1045856006305 POT family; Region: PTR2; pfam00854 1045856006306 endonuclease III; Provisional; Region: PRK10702 1045856006307 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1045856006308 minor groove reading motif; other site 1045856006309 helix-hairpin-helix signature motif; other site 1045856006310 substrate binding pocket [chemical binding]; other site 1045856006311 active site 1045856006312 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 1045856006313 electron transport complex RsxE subunit; Provisional; Region: PRK12405 1045856006314 electron transport complex protein RnfG; Validated; Region: PRK01908 1045856006315 electron transport complex protein RnfD; Reviewed; Region: rnfD; PRK00816 1045856006316 Predicted NADH:ubiquinone oxidoreductase, subunit RnfC [Energy production and conversion]; Region: RnfC; COG4656 1045856006317 SLBB domain; Region: SLBB; pfam10531 1045856006318 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1045856006319 electron transport complex protein RnfB; Provisional; Region: PRK05113 1045856006320 Putative Fe-S cluster; Region: FeS; cl17515 1045856006321 4Fe-4S binding domain; Region: Fer4; pfam00037 1045856006322 electron transport complex protein RsxA; Provisional; Region: PRK05151 1045856006323 Protein of unknown function (DUF2569); Region: DUF2569; pfam10754 1045856006324 oriC-binding nucleoid-associated protein; Provisional; Region: PRK10391 1045856006325 putative oxidoreductase; Provisional; Region: PRK11579 1045856006326 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1045856006327 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1045856006328 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 1045856006329 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 1045856006330 active site 1045856006331 purine riboside binding site [chemical binding]; other site 1045856006332 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 1045856006333 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1045856006334 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1045856006335 homodimer interface [polypeptide binding]; other site 1045856006336 catalytic residue [active] 1045856006337 bifunctional PTS system maltose and glucose-specific transporter subunits IICB; Provisional; Region: PRK10110 1045856006338 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 1045856006339 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1045856006340 active site turn [active] 1045856006341 phosphorylation site [posttranslational modification] 1045856006342 DNA-binding transcriptional repressor MalI; Provisional; Region: PRK10014 1045856006343 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1045856006344 DNA binding site [nucleotide binding] 1045856006345 domain linker motif; other site 1045856006346 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1045856006347 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339 1045856006348 Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097 1045856006349 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 1045856006350 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 1045856006351 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 1045856006352 fumarate hydratase; Provisional; Region: PRK15389 1045856006353 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 1045856006354 Fumarase C-terminus; Region: Fumerase_C; pfam05683 1045856006355 fumarate hydratase; Reviewed; Region: fumC; PRK00485 1045856006356 Class II fumarases; Region: Fumarase_classII; cd01362 1045856006357 active site 1045856006358 tetramer interface [polypeptide binding]; other site 1045856006359 DNA replication terminus site-binding protein; Provisional; Region: PRK02951 1045856006360 sensor protein RstB; Provisional; Region: PRK10604 1045856006361 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1045856006362 dimerization interface [polypeptide binding]; other site 1045856006363 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 1045856006364 dimer interface [polypeptide binding]; other site 1045856006365 phosphorylation site [posttranslational modification] 1045856006366 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1045856006367 ATP binding site [chemical binding]; other site 1045856006368 Mg2+ binding site [ion binding]; other site 1045856006369 G-X-G motif; other site 1045856006370 DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701 1045856006371 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1045856006372 active site 1045856006373 phosphorylation site [posttranslational modification] 1045856006374 intermolecular recognition site; other site 1045856006375 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1045856006376 DNA binding site [nucleotide binding] 1045856006377 GlpM protein; Region: GlpM; pfam06942 1045856006378 dihydromonapterin reductase; Provisional; Region: PRK06483 1045856006379 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1045856006380 NAD(P) binding site [chemical binding]; other site 1045856006381 active site 1045856006382 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 1045856006383 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1045856006384 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1045856006385 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 1045856006386 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 1045856006387 ligand binding site [chemical binding]; other site 1045856006388 homodimer interface [polypeptide binding]; other site 1045856006389 NAD(P) binding site [chemical binding]; other site 1045856006390 trimer interface B [polypeptide binding]; other site 1045856006391 trimer interface A [polypeptide binding]; other site 1045856006392 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 1045856006393 pyridine nucleotide transhydrogenase; Provisional; Region: pntB; PRK09444 1045856006394 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 1045856006395 universal stress protein UspE; Provisional; Region: PRK11175 1045856006396 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1045856006397 Ligand Binding Site [chemical binding]; other site 1045856006398 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1045856006399 Ligand Binding Site [chemical binding]; other site 1045856006400 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 1045856006401 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1045856006402 ligand binding site [chemical binding]; other site 1045856006403 flexible hinge region; other site 1045856006404 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1045856006405 putative switch regulator; other site 1045856006406 non-specific DNA interactions [nucleotide binding]; other site 1045856006407 DNA binding site [nucleotide binding] 1045856006408 sequence specific DNA binding site [nucleotide binding]; other site 1045856006409 putative cAMP binding site [chemical binding]; other site 1045856006410 O-6-alkylguanine-DNA:cysteine-protein methyltransferase; Provisional; Region: PRK10286 1045856006411 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 1045856006412 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1045856006413 DNA binding site [nucleotide binding] 1045856006414 active site 1045856006415 putative aminobenzoyl-glutamate transporter; Provisional; Region: abgT; PRK11339 1045856006416 p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819 1045856006417 M20 Peptidase Aminoacylase 1-like protein 2 aminobenzoyl-glutamate utilization protein B subfamily; Region: M20_Acy1L2_AbgB; cd05673 1045856006418 amidohydrolase; Region: amidohydrolases; TIGR01891 1045856006419 putative metal binding site [ion binding]; other site 1045856006420 M20 Peptidases Aminoacyclase-1 indole-3-acetic-L-aspartic acid hydrolase from bacteria and archaea; Region: M20_Acy1_IAAspH_bact; cd05665 1045856006421 amidohydrolase; Region: amidohydrolases; TIGR01891 1045856006422 putative metal binding site [ion binding]; other site 1045856006423 dimer interface [polypeptide binding]; other site 1045856006424 putative DNA-binding transcriptional regulator; Provisional; Region: PRK09791 1045856006425 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1045856006426 The C-terminal substrate binding domain of LysR-type transcriptional regulator TdcA, which is involved in the degradation of L-serine and L-threonine, contains the type 2 periplasmic binding fold; Region: PBP2_TdcA; cd08418 1045856006427 putative substrate binding pocket [chemical binding]; other site 1045856006428 putative dimerization interface [polypeptide binding]; other site 1045856006429 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 1045856006430 Smr domain; Region: Smr; pfam01713 1045856006431 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 1045856006432 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 1045856006433 dimer interface [polypeptide binding]; other site 1045856006434 ligand binding site [chemical binding]; other site 1045856006435 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1045856006436 dimerization interface [polypeptide binding]; other site 1045856006437 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1045856006438 dimer interface [polypeptide binding]; other site 1045856006439 putative CheW interface [polypeptide binding]; other site 1045856006440 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1045856006441 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1045856006442 active site 1045856006443 catalytic tetrad [active] 1045856006444 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1045856006445 Catalytic site [active] 1045856006446 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 1045856006447 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 1045856006448 active site 1045856006449 DNA binding site [nucleotide binding] 1045856006450 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 1045856006451 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1045856006452 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1045856006453 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1045856006454 putative effector binding pocket; other site 1045856006455 dimerization interface [polypeptide binding]; other site 1045856006456 progesterone 5-beta-reductase-like proteins (5beta-POR), atypical (a) SDRs; Region: 5beta-POR_like_SDR_a; cd08948 1045856006457 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1045856006458 NAD(P) binding site [chemical binding]; other site 1045856006459 active site 1045856006460 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1045856006461 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1045856006462 DNA-binding site [nucleotide binding]; DNA binding site 1045856006463 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1045856006464 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1045856006465 homodimer interface [polypeptide binding]; other site 1045856006466 catalytic residue [active] 1045856006467 N-acetyltransferase; Region: Acetyltransf_2; pfam00797 1045856006468 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1045856006469 active site 1045856006470 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1045856006471 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 1045856006472 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; PRK12287 1045856006473 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1045856006474 multidrug efflux system protein MdtJ; Provisional; Region: PRK10452 1045856006475 multidrug efflux system protein MdtI; Provisional; Region: PRK10650 1045856006476 CHASE4 domain; Region: CHASE4; pfam05228 1045856006477 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1045856006478 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1045856006479 metal binding site [ion binding]; metal-binding site 1045856006480 active site 1045856006481 I-site; other site 1045856006482 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1045856006483 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 1045856006484 TolA protein; Region: tolA_full; TIGR02794 1045856006485 TolA C-terminal; Region: TolA; pfam06519 1045856006486 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1045856006487 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1045856006488 putative substrate translocation pore; other site 1045856006489 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1045856006490 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1045856006491 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1045856006492 dimerization interface [polypeptide binding]; other site 1045856006493 substrate binding pocket [chemical binding]; other site 1045856006494 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 1045856006495 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1045856006496 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1045856006497 nucleotide binding site [chemical binding]; other site 1045856006498 putative dithiobiotin synthetase; Provisional; Region: PRK12374 1045856006499 AAA domain; Region: AAA_26; pfam13500 1045856006500 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 1045856006501 Cl- selectivity filter; other site 1045856006502 Cl- binding residues [ion binding]; other site 1045856006503 pore gating glutamate residue; other site 1045856006504 dimer interface [polypeptide binding]; other site 1045856006505 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 1045856006506 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 1045856006507 Walker A/P-loop; other site 1045856006508 ATP binding site [chemical binding]; other site 1045856006509 Q-loop/lid; other site 1045856006510 ABC transporter signature motif; other site 1045856006511 Walker B; other site 1045856006512 D-loop; other site 1045856006513 H-loop/switch region; other site 1045856006514 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc; cd04582 1045856006515 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1045856006516 dimer interface [polypeptide binding]; other site 1045856006517 conserved gate region; other site 1045856006518 ABC-ATPase subunit interface; other site 1045856006519 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 1045856006520 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1045856006521 dimer interface [polypeptide binding]; other site 1045856006522 conserved gate region; other site 1045856006523 putative PBP binding loops; other site 1045856006524 ABC-ATPase subunit interface; other site 1045856006525 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 1045856006526 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 1045856006527 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1045856006528 putative C-terminal domain interface [polypeptide binding]; other site 1045856006529 putative GSH binding site (G-site) [chemical binding]; other site 1045856006530 putative dimer interface [polypeptide binding]; other site 1045856006531 C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180 1045856006532 putative N-terminal domain interface [polypeptide binding]; other site 1045856006533 putative dimer interface [polypeptide binding]; other site 1045856006534 putative substrate binding pocket (H-site) [chemical binding]; other site 1045856006535 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 1045856006536 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1045856006537 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 1045856006538 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1045856006539 ABC transporter periplasmic binding protein, urea carboxylase region; Region: ABC_peri_uca; TIGR03427 1045856006540 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1045856006541 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1045856006542 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1045856006543 nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184 1045856006544 Walker A/P-loop; other site 1045856006545 ATP binding site [chemical binding]; other site 1045856006546 Q-loop/lid; other site 1045856006547 ABC transporter signature motif; other site 1045856006548 Walker B; other site 1045856006549 D-loop; other site 1045856006550 H-loop/switch region; other site 1045856006551 urea carboxylase-associated protein 2; Region: urea_degr_2; TIGR03425 1045856006552 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 1045856006553 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 1045856006554 Domain of unknown function (DUF1989); Region: DUF1989; pfam09347 1045856006555 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1045856006556 urea carboxylase; Region: urea_carbox; TIGR02712 1045856006557 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1045856006558 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1045856006559 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 1045856006560 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 1045856006561 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1045856006562 carboxyltransferase (CT) interaction site; other site 1045856006563 biotinylation site [posttranslational modification]; other site 1045856006564 allophanate hydrolase; Provisional; Region: PRK08186 1045856006565 Amidase; Region: Amidase; cl11426 1045856006566 twin-argninine leader-binding protein DmsD; Provisional; Region: PRK11621 1045856006567 DMSO reductase anchor subunit [General function prediction only]; Region: DmsC; COG3302 1045856006568 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 1045856006569 4Fe-4S binding domain; Region: Fer4; pfam00037 1045856006570 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 1045856006571 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 1045856006572 putative [Fe4-S4] binding site [ion binding]; other site 1045856006573 putative molybdopterin cofactor binding site [chemical binding]; other site 1045856006574 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 1045856006575 putative molybdopterin cofactor binding site; other site 1045856006576 Protein of unknown function (DUF1161); Region: DUF1161; pfam06649 1045856006577 chloramphenicol acetyltransferase; Provisional; Region: PRK13757 1045856006578 Chloramphenicol O-acetyltransferase [Defense mechanisms]; Region: COG4845 1045856006579 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 1045856006580 Uncharacterized protein family (UPF0257); Region: UPF0257; pfam06788 1045856006581 spermidine N1-acetyltransferase; Provisional; Region: PRK15130 1045856006582 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1045856006583 Coenzyme A binding pocket [chemical binding]; other site 1045856006584 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1045856006585 hypothetical protein; Provisional; Region: PRK13659 1045856006586 hypothetical protein; Provisional; Region: PRK02237 1045856006587 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 1045856006588 The starvation sensing protein RpsA from E.coli and its homologs are lactonizing enzymes whose putative targets are homoserine lactone (HSL)-derivative. They are part of the mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of...; Region: rpsA; cd03322 1045856006589 putative active site pocket [active] 1045856006590 putative metal binding site [ion binding]; other site 1045856006591 putative oxidoreductase; Provisional; Region: PRK10083 1045856006592 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 1045856006593 putative NAD(P) binding site [chemical binding]; other site 1045856006594 catalytic Zn binding site [ion binding]; other site 1045856006595 structural Zn binding site [ion binding]; other site 1045856006596 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1045856006597 metabolite-proton symporter; Region: 2A0106; TIGR00883 1045856006598 putative substrate translocation pore; other site 1045856006599 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 1045856006600 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1045856006601 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1045856006602 YdfZ protein; Region: YdfZ; pfam14001 1045856006603 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1045856006604 Ligand Binding Site [chemical binding]; other site 1045856006605 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1045856006606 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1045856006607 DNA-binding site [nucleotide binding]; DNA binding site 1045856006608 FCD domain; Region: FCD; pfam07729 1045856006609 malonic semialdehyde reductase; Provisional; Region: PRK10538 1045856006610 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 1045856006611 putative NAD(P) binding site [chemical binding]; other site 1045856006612 homodimer interface [polypeptide binding]; other site 1045856006613 homotetramer interface [polypeptide binding]; other site 1045856006614 active site 1045856006615 dipeptidyl carboxypeptidase II; Provisional; Region: PRK10280 1045856006616 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 1045856006617 active site 1045856006618 Zn binding site [ion binding]; other site 1045856006619 Replication protein P; Region: Phage_lambda_P; pfam06992 1045856006620 outer membrane usher protein; Provisional; Region: PRK15193 1045856006621 PapC N-terminal domain; Region: PapC_N; pfam13954 1045856006622 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1045856006623 PapC C-terminal domain; Region: PapC_C; pfam13953 1045856006624 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 1045856006625 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1045856006626 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1045856006627 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1045856006628 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1045856006629 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1045856006630 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1045856006631 DNA binding site [nucleotide binding] 1045856006632 Uncharacterized conserved protein [Function unknown]; Region: COG4925 1045856006633 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 1045856006634 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 1045856006635 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1045856006636 anti-RssB factor; Provisional; Region: PRK10244 1045856006637 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1045856006638 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1045856006639 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1045856006640 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1045856006641 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1045856006642 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 1045856006643 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1045856006644 putative ligand binding site [chemical binding]; other site 1045856006645 putative NAD binding site [chemical binding]; other site 1045856006646 catalytic site [active] 1045856006647 hypothetical protein; Provisional; Region: PRK10695 1045856006648 YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617 1045856006649 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3784 1045856006650 DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685 1045856006651 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1045856006652 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1045856006653 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1045856006654 NAD(P) binding site [chemical binding]; other site 1045856006655 catalytic residues [active] 1045856006656 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1045856006657 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1045856006658 metal binding site [ion binding]; metal-binding site 1045856006659 active site 1045856006660 I-site; other site 1045856006661 Divergent PAP2 family; Region: DUF212; cl00855 1045856006662 tyramine oxidase; Provisional; Region: tynA; PRK14696 1045856006663 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 1045856006664 Copper amine oxidase, N2 domain; Region: Cu_amine_oxidN2; pfam02727 1045856006665 Copper amine oxidase, N3 domain; Region: Cu_amine_oxidN3; pfam02728 1045856006666 Copper amine oxidase, enzyme domain; Region: Cu_amine_oxid; pfam01179 1045856006667 bifunctional aldehyde dehydrogenase/enoyl-CoA hydratase; Provisional; Region: PRK11563 1045856006668 N-terminal domain of the monoamine oxidase C dehydratase; Region: ALDH_MaoC-N; cd07128 1045856006669 substrate binding site [chemical binding]; other site 1045856006670 dimer interface [polypeptide binding]; other site 1045856006671 NADP binding site [chemical binding]; other site 1045856006672 catalytic residues [active] 1045856006673 MaoC_C The C-terminal hot dog fold of the MaoC (monoamine oxidase C) dehydratase regulatory protein. Orthologs of MaoC include PaaZ [Escherichia coli] and PaaN [Pseudomonas putida], which are putative ring-opening enzymes involved in phenylacetic acid...; Region: MaoC_C; cd03452 1045856006674 substrate binding site [chemical binding]; other site 1045856006675 phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778 1045856006676 phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156 1045856006677 phenylacetate-CoA oxygenase subunit PaaB; Provisional; Region: paaB; PRK13781 1045856006678 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; pfam05138 1045856006679 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 1045856006680 phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159 1045856006681 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 1045856006682 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 1045856006683 FAD binding pocket [chemical binding]; other site 1045856006684 FAD binding motif [chemical binding]; other site 1045856006685 phosphate binding motif [ion binding]; other site 1045856006686 beta-alpha-beta structure motif; other site 1045856006687 NAD(p) ribose binding residues [chemical binding]; other site 1045856006688 NAD binding pocket [chemical binding]; other site 1045856006689 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 1045856006690 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1045856006691 catalytic loop [active] 1045856006692 iron binding site [ion binding]; other site 1045856006693 enoyl-CoA hydratase-isomerase; Provisional; Region: PRK09674 1045856006694 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1045856006695 substrate binding site [chemical binding]; other site 1045856006696 oxyanion hole (OAH) forming residues; other site 1045856006697 trimer interface [polypeptide binding]; other site 1045856006698 enoyl-CoA hydratase; Provisional; Region: PRK08140 1045856006699 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1045856006700 substrate binding site [chemical binding]; other site 1045856006701 oxyanion hole (OAH) forming residues; other site 1045856006702 trimer interface [polypeptide binding]; other site 1045856006703 3-hydroxy-acyl-CoA dehydrogenase; Validated; Region: PRK08268 1045856006704 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1045856006705 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1045856006706 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1045856006707 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1045856006708 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1045856006709 CoenzymeA binding site [chemical binding]; other site 1045856006710 subunit interaction site [polypeptide binding]; other site 1045856006711 PHB binding site; other site 1045856006712 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 1045856006713 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1045856006714 dimer interface [polypeptide binding]; other site 1045856006715 active site 1045856006716 Phenylacetate-CoA ligase (also known as PaaK); Region: PaaK; cd05913 1045856006717 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 1045856006718 active site 1045856006719 AMP binding site [chemical binding]; other site 1045856006720 homodimer interface [polypeptide binding]; other site 1045856006721 acyl-activating enzyme (AAE) consensus motif; other site 1045856006722 CoA binding site [chemical binding]; other site 1045856006723 PaaX-like protein; Region: PaaX; pfam07848 1045856006724 phenylacetic acid degradation operon negative regulatory protein PaaX; Region: PaaX_trns_reg; TIGR02277 1045856006725 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 1045856006726 phenylacetic acid degradation protein PaaY; Region: PaaY; TIGR02287 1045856006727 paaY-like: This group is composed by uncharacterized proteins with similarity to the protein product of the E. coli paaY gene, which is part of the paa gene cluster responsible for phenylacetic acid degradation. Proteins in this group are expected to...; Region: LbH_paaY_like; cd04745 1045856006728 putative trimer interface [polypeptide binding]; other site 1045856006729 putative metal binding site [ion binding]; other site 1045856006730 outer membrane protease; Reviewed; Region: PRK10993 1045856006731 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1045856006732 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1045856006733 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1045856006734 dimerization interface [polypeptide binding]; other site 1045856006735 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 1045856006736 hypothetical protein; Provisional; Region: PRK08204 1045856006737 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1045856006738 active site 1045856006739 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1045856006740 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1045856006741 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 1045856006742 putative effector binding pocket; other site 1045856006743 putative dimerization interface [polypeptide binding]; other site 1045856006744 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1045856006745 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1045856006746 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1045856006747 HlyD family secretion protein; Region: HlyD_3; pfam13437 1045856006748 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1045856006749 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1045856006750 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1045856006751 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1045856006752 NAD(P) binding site [chemical binding]; other site 1045856006753 active site 1045856006754 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1045856006755 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1045856006756 DNA binding residues [nucleotide binding] 1045856006757 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1045856006758 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1045856006759 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1045856006760 putative effector binding pocket; other site 1045856006761 dimerization interface [polypeptide binding]; other site 1045856006762 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1045856006763 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 1045856006764 FMN binding site [chemical binding]; other site 1045856006765 active site 1045856006766 substrate binding site [chemical binding]; other site 1045856006767 catalytic residue [active] 1045856006768 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 1045856006769 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1045856006770 NAD(P) binding site [chemical binding]; other site 1045856006771 active site 1045856006772 SnoaL-like polyketide cyclase; Region: SnoaL; pfam07366 1045856006773 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3558 1045856006774 SnoaL-like domain; Region: SnoaL_2; pfam12680 1045856006775 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1045856006776 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1045856006777 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 1045856006778 SnoaL-like domain; Region: SnoaL_2; pfam12680 1045856006779 short chain dehydrogenase; Provisional; Region: PRK06101 1045856006780 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1045856006781 NAD(P) binding site [chemical binding]; other site 1045856006782 active site 1045856006783 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 1045856006784 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1045856006785 Protein of unknown function (DUF1365); Region: DUF1365; pfam07103 1045856006786 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 1045856006787 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1045856006788 S-adenosylmethionine binding site [chemical binding]; other site 1045856006789 Protein of unknown function (DUF2878); Region: DUF2878; pfam11086 1045856006790 Protein of unknown function (DUF3833); Region: DUF3833; pfam12915 1045856006791 Protein of unknown function, DUF606; Region: DUF606; pfam04657 1045856006792 Protein of unknown function, DUF606; Region: DUF606; pfam04657 1045856006793 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1045856006794 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1045856006795 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1045856006796 putative effector binding pocket; other site 1045856006797 dimerization interface [polypeptide binding]; other site 1045856006798 methionine synthase; Provisional; Region: PRK01207 1045856006799 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1045856006800 substrate binding site [chemical binding]; other site 1045856006801 THF binding site; other site 1045856006802 zinc-binding site [ion binding]; other site 1045856006803 Domain of unknown function (DUF1852); Region: DUF1852; pfam08908 1045856006804 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3122 1045856006805 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1045856006806 pseudouridine synthase; Region: TIGR00093 1045856006807 active site 1045856006808 azoreductase; Reviewed; Region: PRK00170 1045856006809 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1045856006810 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 1045856006811 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1045856006812 ATP binding site [chemical binding]; other site 1045856006813 putative Mg++ binding site [ion binding]; other site 1045856006814 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1045856006815 nucleotide binding region [chemical binding]; other site 1045856006816 ATP-binding site [chemical binding]; other site 1045856006817 Helicase associated domain (HA2); Region: HA2; pfam04408 1045856006818 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 1045856006819 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 1045856006820 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1045856006821 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1045856006822 S-adenosylmethionine binding site [chemical binding]; other site 1045856006823 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 1045856006824 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 1045856006825 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1045856006826 HlyD family secretion protein; Region: HlyD_3; pfam13437 1045856006827 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1045856006828 putative substrate translocation pore; other site 1045856006829 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1045856006830 Uncharacterized conserved protein [Function unknown]; Region: COG1434 1045856006831 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1045856006832 putative active site [active] 1045856006833 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 1045856006834 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1045856006835 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1045856006836 cytochrome b561; Provisional; Region: PRK11513 1045856006837 putative oxidoreductase; Provisional; Region: PRK11579 1045856006838 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1045856006839 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1045856006840 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1045856006841 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1045856006842 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1045856006843 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 1045856006844 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 1045856006845 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1045856006846 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1045856006847 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 1045856006848 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 1045856006849 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 1045856006850 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1045856006851 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 1045856006852 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 1045856006853 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1045856006854 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1045856006855 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 1045856006856 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1045856006857 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 1045856006858 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1045856006859 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 1045856006860 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1045856006861 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1045856006862 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 1045856006863 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1045856006864 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 1045856006865 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 1045856006866 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1045856006867 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1045856006868 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 1045856006869 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 1045856006870 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1045856006871 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1045856006872 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1045856006873 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 1045856006874 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1045856006875 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1045856006876 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 1045856006877 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1045856006878 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 1045856006879 Family description; Region: VCBS; pfam13517 1045856006880 Family description; Region: VCBS; pfam13517 1045856006881 Family description; Region: VCBS; pfam13517 1045856006882 type I secretion C-terminal target domain (VC_A0849 subclass); Region: T1SS_VCA0849; TIGR03661 1045856006883 type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375 1045856006884 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 1045856006885 putative active site [active] 1045856006886 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1045856006887 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1045856006888 Walker A/P-loop; other site 1045856006889 ATP binding site [chemical binding]; other site 1045856006890 Q-loop/lid; other site 1045856006891 ABC transporter signature motif; other site 1045856006892 Walker B; other site 1045856006893 D-loop; other site 1045856006894 H-loop/switch region; other site 1045856006895 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 1045856006896 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1045856006897 HlyD family secretion protein; Region: HlyD_3; pfam13437 1045856006898 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1045856006899 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1045856006900 DNA binding residues [nucleotide binding] 1045856006901 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1045856006902 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1636 1045856006903 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 1045856006904 putative metal binding site [ion binding]; other site 1045856006905 putative homodimer interface [polypeptide binding]; other site 1045856006906 putative homotetramer interface [polypeptide binding]; other site 1045856006907 putative homodimer-homodimer interface [polypeptide binding]; other site 1045856006908 putative allosteric switch controlling residues; other site 1045856006909 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 1045856006910 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 1045856006911 substrate binding site [chemical binding]; other site 1045856006912 catalytic Zn binding site [ion binding]; other site 1045856006913 NAD binding site [chemical binding]; other site 1045856006914 structural Zn binding site [ion binding]; other site 1045856006915 dimer interface [polypeptide binding]; other site 1045856006916 methyl-accepting protein IV; Provisional; Region: PRK09793 1045856006917 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 1045856006918 dimer interface [polypeptide binding]; other site 1045856006919 ligand binding site [chemical binding]; other site 1045856006920 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1045856006921 dimerization interface [polypeptide binding]; other site 1045856006922 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1045856006923 dimer interface [polypeptide binding]; other site 1045856006924 putative CheW interface [polypeptide binding]; other site 1045856006925 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 1045856006926 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 1045856006927 Trp docking motif [polypeptide binding]; other site 1045856006928 putative active site [active] 1045856006929 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 1045856006930 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1045856006931 The C-terminal substrate binding domain of galactose-binding protein regulator contains the type 2 periplasmic binding fold; Region: PBP2_GbpR; cd08435 1045856006932 putative dimerization interface [polypeptide binding]; other site 1045856006933 oxidoreductase; Provisional; Region: PRK06128 1045856006934 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 1045856006935 NAD binding site [chemical binding]; other site 1045856006936 metal binding site [ion binding]; metal-binding site 1045856006937 active site 1045856006938 hypothetical protein; Provisional; Region: PRK10053 1045856006939 Predicted membrane protein [Function unknown]; Region: COG2323 1045856006940 hypothetical protein; Validated; Region: PRK03657 1045856006941 short chain dehydrogenase; Provisional; Region: PRK07109 1045856006942 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1045856006943 NAD(P) binding site [chemical binding]; other site 1045856006944 active site 1045856006945 trehalose synthase; Region: treS_nterm; TIGR02456 1045856006946 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 1045856006947 active site 1045856006948 catalytic site [active] 1045856006949 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1045856006950 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1045856006951 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 1045856006952 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 1045856006953 dimanganese center [ion binding]; other site 1045856006954 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 1045856006955 dinuclear metal binding motif [ion binding]; other site 1045856006956 YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909 1045856006957 dimerization interface [polypeptide binding]; other site 1045856006958 metal binding site [ion binding]; metal-binding site 1045856006959 General stress protein [General function prediction only]; Region: GsiB; COG3729 1045856006960 Domain of unknown function (DUF1338); Region: DUF1338; pfam07063 1045856006961 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 1045856006962 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 1045856006963 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1045856006964 substrate binding pocket [chemical binding]; other site 1045856006965 catalytic triad [active] 1045856006966 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1045856006967 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1045856006968 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1045856006969 dimerization interface [polypeptide binding]; other site 1045856006970 putative aminotransferase; Provisional; Region: PRK12414 1045856006971 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1045856006972 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1045856006973 homodimer interface [polypeptide binding]; other site 1045856006974 catalytic residue [active] 1045856006975 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 1045856006976 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1045856006977 substrate binding pocket [chemical binding]; other site 1045856006978 membrane-bound complex binding site; other site 1045856006979 hinge residues; other site 1045856006980 Periplasmic glucans biosynthesis protein [Inorganic ion transport and metabolism]; Region: MdoG; COG3131 1045856006981 TAT (twin-arginine translocation) pathway signal sequence; Region: TAT_signal; pfam10518 1045856006982 glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273 1045856006983 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1045856006984 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1045856006985 Coenzyme A binding pocket [chemical binding]; other site 1045856006986 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1045856006987 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cd00208 1045856006988 putative trimer interface [polypeptide binding]; other site 1045856006989 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1045856006990 putative trimer interface [polypeptide binding]; other site 1045856006991 putative CoA binding site [chemical binding]; other site 1045856006992 putative CoA binding site [chemical binding]; other site 1045856006993 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 1045856006994 Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes TehA protein; Region: TDT_TehA; cd09324 1045856006995 gating phenylalanine in ion channel; other site 1045856006996 tellurite resistance protein TehB; Provisional; Region: PRK11207 1045856006997 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1045856006998 S-adenosylmethionine binding site [chemical binding]; other site 1045856006999 Di- and tripeptidases [Amino acid transport and metabolism]; Region: PepD; COG2195 1045856007000 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 1045856007001 metal binding site [ion binding]; metal-binding site 1045856007002 dimer interface [polypeptide binding]; other site 1045856007003 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1045856007004 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 1045856007005 peptide binding site [polypeptide binding]; other site 1045856007006 Protein of unknown function (DUF3313); Region: DUF3313; pfam11769 1045856007007 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 1045856007008 EamA-like transporter family; Region: EamA; pfam00892 1045856007009 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 1045856007010 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1045856007011 benzoate transporter; Region: benE; TIGR00843 1045856007012 Uncharacterized protein involved in benzoate metabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BenE; COG3135 1045856007013 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1045856007014 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1045856007015 non-specific DNA binding site [nucleotide binding]; other site 1045856007016 salt bridge; other site 1045856007017 sequence-specific DNA binding site [nucleotide binding]; other site 1045856007018 Cupin domain; Region: Cupin_2; pfam07883 1045856007019 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1045856007020 Peptidase family U32; Region: Peptidase_U32; pfam01136 1045856007021 Collagenase; Region: DUF3656; pfam12392 1045856007022 Protein of unknown function (DUF2554); Region: DUF2554; pfam10829 1045856007023 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 1045856007024 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 1045856007025 conserved cys residue [active] 1045856007026 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1045856007027 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1045856007028 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 1045856007029 active site residue [active] 1045856007030 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1045856007031 substrate binding site [chemical binding]; other site 1045856007032 THF binding site; other site 1045856007033 zinc-binding site [ion binding]; other site 1045856007034 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1045856007035 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 1045856007036 putative ligand binding site [chemical binding]; other site 1045856007037 HEAT repeats; Region: HEAT_2; pfam13646 1045856007038 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1045856007039 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1045856007040 TM-ABC transporter signature motif; other site 1045856007041 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1045856007042 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1045856007043 TM-ABC transporter signature motif; other site 1045856007044 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 1045856007045 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1045856007046 Walker A/P-loop; other site 1045856007047 ATP binding site [chemical binding]; other site 1045856007048 Q-loop/lid; other site 1045856007049 ABC transporter signature motif; other site 1045856007050 Walker B; other site 1045856007051 D-loop; other site 1045856007052 H-loop/switch region; other site 1045856007053 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 1045856007054 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1045856007055 Walker A/P-loop; other site 1045856007056 ATP binding site [chemical binding]; other site 1045856007057 Q-loop/lid; other site 1045856007058 ABC transporter signature motif; other site 1045856007059 Walker B; other site 1045856007060 D-loop; other site 1045856007061 H-loop/switch region; other site 1045856007062 zinc/cadmium-binding protein; Provisional; Region: PRK10306 1045856007063 putative transporter; Provisional; Region: PRK10054 1045856007064 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1045856007065 putative substrate translocation pore; other site 1045856007066 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 1045856007067 EamA-like transporter family; Region: EamA; pfam00892 1045856007068 hypothetical protein; Provisional; Region: PRK10106 1045856007069 DNA-binding transcriptional activator MarA; Provisional; Region: PRK11511 1045856007070 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1045856007071 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1045856007072 DNA-binding transcriptional repressor MarR; Provisional; Region: PRK11512 1045856007073 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1045856007074 inner membrane protein; Provisional; Region: PRK10995 1045856007075 putative arabinose transporter; Provisional; Region: PRK03545 1045856007076 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1045856007077 putative substrate translocation pore; other site 1045856007078 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 1045856007079 NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs; Region: NmrA_like_SDR_a; cd05251 1045856007080 NmrA-like family; Region: NmrA; pfam05368 1045856007081 NADP binding site [chemical binding]; other site 1045856007082 active site 1045856007083 regulatory binding site [polypeptide binding]; other site 1045856007084 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 1045856007085 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1045856007086 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1045856007087 dimerization interface [polypeptide binding]; other site 1045856007088 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1045856007089 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 1045856007090 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1045856007091 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 1045856007092 putative dimerization interface [polypeptide binding]; other site 1045856007093 putative succinate semialdehyde dehydrogenase; Provisional; Region: PRK13968 1045856007094 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 1045856007095 NAD(P) binding site [chemical binding]; other site 1045856007096 catalytic residues [active] 1045856007097 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 1045856007098 dimer interface [polypeptide binding]; other site 1045856007099 ligand binding site [chemical binding]; other site 1045856007100 HAMP domain; Region: HAMP; pfam00672 1045856007101 dimerization interface [polypeptide binding]; other site 1045856007102 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1045856007103 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1045856007104 dimer interface [polypeptide binding]; other site 1045856007105 putative CheW interface [polypeptide binding]; other site 1045856007106 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 1045856007107 glutaminase; Provisional; Region: PRK00971 1045856007108 Domain of unknown function (DUF4186); Region: DUF4186; pfam13811 1045856007109 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1045856007110 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1045856007111 metal binding site [ion binding]; metal-binding site 1045856007112 active site 1045856007113 I-site; other site 1045856007114 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1045856007115 GAF domain; Region: GAF; pfam01590 1045856007116 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1045856007117 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1045856007118 metal binding site [ion binding]; metal-binding site 1045856007119 active site 1045856007120 I-site; other site 1045856007121 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 1045856007122 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1045856007123 Coenzyme A binding pocket [chemical binding]; other site 1045856007124 altronate oxidoreductase; Provisional; Region: PRK03643 1045856007125 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1045856007126 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1045856007127 Predicted membrane protein [Function unknown]; Region: COG3781 1045856007128 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1045856007129 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 1045856007130 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1045856007131 Coenzyme A binding pocket [chemical binding]; other site 1045856007132 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1045856007133 osmolarity response regulator; Provisional; Region: ompR; PRK09468 1045856007134 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1045856007135 active site 1045856007136 phosphorylation site [posttranslational modification] 1045856007137 intermolecular recognition site; other site 1045856007138 dimerization interface [polypeptide binding]; other site 1045856007139 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1045856007140 DNA binding site [nucleotide binding] 1045856007141 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1045856007142 dimer interface [polypeptide binding]; other site 1045856007143 phosphorylation site [posttranslational modification] 1045856007144 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1045856007145 ATP binding site [chemical binding]; other site 1045856007146 Mg2+ binding site [ion binding]; other site 1045856007147 G-X-G motif; other site 1045856007148 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1045856007149 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1045856007150 TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012 1045856007151 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1045856007152 catalytic residues [active] 1045856007153 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 1045856007154 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1045856007155 S-adenosylmethionine binding site [chemical binding]; other site 1045856007156 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 1045856007157 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1045856007158 dimer interface [polypeptide binding]; other site 1045856007159 ADP-ribose binding site [chemical binding]; other site 1045856007160 active site 1045856007161 nudix motif; other site 1045856007162 metal binding site [ion binding]; metal-binding site 1045856007163 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1045856007164 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1045856007165 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1045856007166 Domain of unknown function (DUF4406); Region: DUF4406; pfam14359 1045856007167 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1045856007168 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1045856007169 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1045856007170 dimerization interface [polypeptide binding]; other site 1045856007171 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 1045856007172 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1045856007173 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1045856007174 active site 1045856007175 catalytic tetrad [active] 1045856007176 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 1045856007177 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1045856007178 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1045856007179 Beta-lactamase; Region: Beta-lactamase; pfam00144 1045856007180 heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914 1045856007181 copper/silver efflux system membrane fusion protein CusB; Provisional; Region: PRK09783 1045856007182 HlyD family secretion protein; Region: HlyD_3; pfam13437 1045856007183 Copper binding periplasmic protein CusF; Region: CusF_Ec; cl02363 1045856007184 copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837 1045856007185 DNA-binding transcriptional activator CusR; Provisional; Region: PRK09836 1045856007186 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1045856007187 active site 1045856007188 phosphorylation site [posttranslational modification] 1045856007189 intermolecular recognition site; other site 1045856007190 dimerization interface [polypeptide binding]; other site 1045856007191 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1045856007192 DNA binding site [nucleotide binding] 1045856007193 sensor kinase CusS; Provisional; Region: PRK09835 1045856007194 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1045856007195 dimerization interface [polypeptide binding]; other site 1045856007196 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1045856007197 dimer interface [polypeptide binding]; other site 1045856007198 phosphorylation site [posttranslational modification] 1045856007199 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1045856007200 ATP binding site [chemical binding]; other site 1045856007201 Mg2+ binding site [ion binding]; other site 1045856007202 G-X-G motif; other site 1045856007203 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1045856007204 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1045856007205 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_1; cd08460 1045856007206 putative substrate binding pocket [chemical binding]; other site 1045856007207 putative dimerization interface [polypeptide binding]; other site 1045856007208 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1045856007209 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1045856007210 putative substrate translocation pore; other site 1045856007211 Protein of unknown function (DUF2891); Region: DUF2891; pfam11199 1045856007212 Predicted membrane protein [Function unknown]; Region: COG3817 1045856007213 Protein of unknown function (DUF979); Region: DUF979; pfam06166 1045856007214 Protein of unknown function (DUF969); Region: DUF969; pfam06149 1045856007215 MarR family; Region: MarR_2; cl17246 1045856007216 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 1045856007217 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 1045856007218 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 1045856007219 active site 1045856007220 catalytic site [active] 1045856007221 malto-oligosyltrehalose synthase; Region: trehalose_TreY; TIGR02401 1045856007222 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 1045856007223 active site 1045856007224 catalytic site [active] 1045856007225 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 1045856007226 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 1045856007227 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 1045856007228 catalytic site [active] 1045856007229 active site 1045856007230 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 1045856007231 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1045856007232 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1045856007233 Coenzyme A binding pocket [chemical binding]; other site 1045856007234 HAD superfamily, subfamily IIIB (Acid phosphatase); Region: Acid_phosphat_B; cl17236 1045856007235 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 1045856007236 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1045856007237 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1045856007238 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1045856007239 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 1045856007240 substrate binding pocket [chemical binding]; other site 1045856007241 dimerization interface [polypeptide binding]; other site 1045856007242 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 1045856007243 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1045856007244 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1045856007245 dimerization interface [polypeptide binding]; other site 1045856007246 substrate binding pocket [chemical binding]; other site 1045856007247 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; pfam01977 1045856007248 Uncharacterized conserved protein (DUF2132); Region: DUF2132; pfam09905 1045856007249 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649 1045856007250 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 1045856007251 disulfide isomerase/thiol-disulfide oxidase; Provisional; Region: dsbG; PRK11657 1045856007252 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 1045856007253 dimerization domain [polypeptide binding]; other site 1045856007254 dimer interface [polypeptide binding]; other site 1045856007255 catalytic residues [active] 1045856007256 conjugal transfer protein TrbB; Provisional; Region: PRK13728; cl17283 1045856007257 DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023 1045856007258 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1045856007259 catalytic residues [active] 1045856007260 Disulphide bond corrector protein DsbC; Region: DsbC; cl15830 1045856007261 Thiol:disulfide interchange protein [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4232 1045856007262 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1045856007263 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 1045856007264 DsbD alpha interface [polypeptide binding]; other site 1045856007265 catalytic residues [active] 1045856007266 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1045856007267 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1045856007268 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1045856007269 DNA binding residues [nucleotide binding] 1045856007270 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 1045856007271 phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644 1045856007272 Phage P2 baseplate assembly protein gpV [General function prediction only]; Region: gpV; COG4540 1045856007273 tail protein; Provisional; Region: D; PHA02561 1045856007274 Phage P2 GpU; Region: Phage_P2_GpU; pfam06995 1045856007275 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 1045856007276 Phage P2 GpE; Region: Phage_P2_GpE; pfam06528 1045856007277 Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109 1045856007278 major tail tube protein; Provisional; Region: FII; PHA02600 1045856007279 major tail sheath protein; Provisional; Region: FI; PHA02560 1045856007280 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 1045856007281 Phage tail-collar fibre protein; Region: DUF3751; pfam12571 1045856007282 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 1045856007283 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 1045856007284 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 1045856007285 phage tail protein, P2 protein I family; Region: tail_P2_I; TIGR01634 1045856007286 baseplate assembly protein; Provisional; Region: J; PHA02568 1045856007287 baseplate wedge subunit; Provisional; Region: W; PHA02516 1045856007288 phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644 1045856007289 Phage P2 baseplate assembly protein gpV [General function prediction only]; Region: gpV; COG4540 1045856007290 Phage virion morphogenesis family; Region: Phage_tail_S; pfam05069 1045856007291 P2 phage tail completion protein R (GpR); Region: P2_Phage_GpR; pfam06891 1045856007292 phage lysis regulatory protein, LysB family; Region: phage_LysB; TIGR03495 1045856007293 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 1045856007294 catalytic residues [active] 1045856007295 Phage head completion protein (GPL); Region: Phage_GPL; pfam05926 1045856007296 Phage small terminase subunit; Region: Phage_term_smal; pfam05944 1045856007297 terminase ATPase subunit; Provisional; Region: P; PHA02535 1045856007298 Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056 1045856007299 portal vertex protein; Provisional; Region: Q; PHA02536 1045856007300 Phage portal protein; Region: Phage_portal; pfam04860 1045856007301 Protein of unknown function DUF262; Region: DUF262; pfam03235 1045856007302 Uncharacterized conserved protein [Function unknown]; Region: COG1479 1045856007303 Domain of Unknown Function with PDB structure (DUF3850); Region: DUF3850; pfam12961 1045856007304 Bacteriophage replication gene A protein (GPA); Region: Phage_GPA; pfam05840 1045856007305 integrase; Provisional; Region: int; PHA02601 1045856007306 Phage HP1 integrase, C-terminal catalytic domain. Bacteriophage HP1 and related integrases are found in eubacteria, plasmids and temperate bacteriophages of the P2 family. They belong to the DNA breaking-rejoining enzyme superfamily, which includes...; Region: HP1_INT_C; cd00797 1045856007307 dimer interface [polypeptide binding]; other site 1045856007308 active site 1045856007309 catalytic residues [active] 1045856007310 Int/Topo IB signature motif; other site 1045856007311 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 1045856007312 dimer interface [polypeptide binding]; other site 1045856007313 ligand binding site [chemical binding]; other site 1045856007314 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 1045856007315 dimerization interface [polypeptide binding]; other site 1045856007316 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1045856007317 dimer interface [polypeptide binding]; other site 1045856007318 putative CheW interface [polypeptide binding]; other site 1045856007319 D-fructose-responsive transcription factor; Region: fruct_sucro_rep; TIGR02417 1045856007320 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1045856007321 DNA binding site [nucleotide binding] 1045856007322 domain linker motif; other site 1045856007323 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 1045856007324 dimerization interface [polypeptide binding]; other site 1045856007325 ligand binding site [chemical binding]; other site 1045856007326 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 1045856007327 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 1045856007328 substrate binding [chemical binding]; other site 1045856007329 active site 1045856007330 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 1045856007331 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 1045856007332 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1045856007333 active site turn [active] 1045856007334 phosphorylation site [posttranslational modification] 1045856007335 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1045856007336 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 1045856007337 trimer interface; other site 1045856007338 sugar binding site [chemical binding]; other site 1045856007339 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1045856007340 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 1045856007341 putative substrate binding site [chemical binding]; other site 1045856007342 putative ATP binding site [chemical binding]; other site 1045856007343 Sensors of blue-light using FAD; Region: BLUF; pfam04940 1045856007344 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1045856007345 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1045856007346 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1045856007347 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1045856007348 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1045856007349 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 1045856007350 D-alanyl-D-alanine dipeptidase; Provisional; Region: PRK10178 1045856007351 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1045856007352 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 1045856007353 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1045856007354 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1045856007355 dimer interface [polypeptide binding]; other site 1045856007356 conserved gate region; other site 1045856007357 putative PBP binding loops; other site 1045856007358 ABC-ATPase subunit interface; other site 1045856007359 D-ala-D-ala transporter subunit; Provisional; Region: PRK09881 1045856007360 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1045856007361 dimer interface [polypeptide binding]; other site 1045856007362 conserved gate region; other site 1045856007363 putative PBP binding loops; other site 1045856007364 ABC-ATPase subunit interface; other site 1045856007365 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1045856007366 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1045856007367 Walker A/P-loop; other site 1045856007368 ATP binding site [chemical binding]; other site 1045856007369 Q-loop/lid; other site 1045856007370 ABC transporter signature motif; other site 1045856007371 Walker B; other site 1045856007372 D-loop; other site 1045856007373 H-loop/switch region; other site 1045856007374 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1045856007375 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 1045856007376 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1045856007377 Walker A/P-loop; other site 1045856007378 ATP binding site [chemical binding]; other site 1045856007379 Q-loop/lid; other site 1045856007380 ABC transporter signature motif; other site 1045856007381 Walker B; other site 1045856007382 D-loop; other site 1045856007383 H-loop/switch region; other site 1045856007384 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1045856007385 short chain dehydrogenase; Provisional; Region: PRK06500 1045856007386 classical (c) SDRs; Region: SDR_c; cd05233 1045856007387 NAD(P) binding site [chemical binding]; other site 1045856007388 active site 1045856007389 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1045856007390 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1045856007391 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 1045856007392 putative effector binding pocket; other site 1045856007393 putative dimerization interface [polypeptide binding]; other site 1045856007394 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 1045856007395 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1045856007396 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1045856007397 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1045856007398 putative effector binding pocket; other site 1045856007399 dimerization interface [polypeptide binding]; other site 1045856007400 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1045856007401 30S ribosomal subunit S22; Reviewed; Region: rpsV; PRK10057 1045856007402 malate dehydrogenase; Provisional; Region: PRK13529 1045856007403 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1045856007404 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 1045856007405 NAD(P) binding site [chemical binding]; other site 1045856007406 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1045856007407 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1045856007408 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1045856007409 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 1045856007410 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 1045856007411 NAD binding site [chemical binding]; other site 1045856007412 substrate binding site [chemical binding]; other site 1045856007413 catalytic Zn binding site [ion binding]; other site 1045856007414 tetramer interface [polypeptide binding]; other site 1045856007415 structural Zn binding site [ion binding]; other site 1045856007416 Predicted transcriptional regulator [Transcription]; Region: COG1959 1045856007417 Transcriptional regulator; Region: Rrf2; pfam02082 1045856007418 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1045856007419 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1045856007420 MFS transport protein AraJ; Provisional; Region: PRK10091 1045856007421 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1045856007422 putative substrate translocation pore; other site 1045856007423 hypothetical protein; Provisional; Region: PRK09951 1045856007424 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 1045856007425 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 1045856007426 active site 1045856007427 DNA binding site [nucleotide binding] 1045856007428 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 1045856007429 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 1045856007430 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1045856007431 Catalytic site [active] 1045856007432 Phage terminase large subunit; Region: Terminase_3; cl12054 1045856007433 Uncharacterized conserved protein (DUF2280); Region: DUF2280; pfam10045 1045856007434 Phage antitermination protein Q; Region: Phage_antiter_Q; pfam06323 1045856007435 endodeoxyribonuclease RUS; Reviewed; Region: PRK09786 1045856007436 Protein of unknown function (DUF1364); Region: DUF1364; pfam07102 1045856007437 prophage protein NinE; Provisional; Region: PRK09689 1045856007438 hypothetical protein; Provisional; Region: PRK09741 1045856007439 Replication protein P; Region: Phage_lambda_P; pfam06992 1045856007440 Bacteriophage replication protein O; Region: Phage_rep_O; cl04545 1045856007441 Protein of unknown function (DUF1019); Region: DUF1019; pfam06254 1045856007442 Cro; Region: Cro; pfam09048 1045856007443 FtsZ inhibitor protein; Reviewed; Region: kil; PRK11354 1045856007444 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 1045856007445 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1045856007446 cofactor binding site; other site 1045856007447 DNA binding site [nucleotide binding] 1045856007448 substrate interaction site [chemical binding]; other site 1045856007449 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1045856007450 DNA N-6-adenine-methyltransferase (Dam); Region: Dam; cl05442 1045856007451 Putative excisionase (DUF1233); Region: DUF1233; pfam06806 1045856007452 Domain of unknown function (DUF3596); Region: DUF3596; pfam12167 1045856007453 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1045856007454 phiCTX phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various phage and bacterial integrases, including those similar to phage integrases: Bordetella and...; Region: INT_phiCTX_C; cd01191 1045856007455 Int/Topo IB signature motif; other site 1045856007456 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 1045856007457 formate dehydrogenase-N subunit gamma; Provisional; Region: PRK10179 1045856007458 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 1045856007459 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 1045856007460 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 1045856007461 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1045856007462 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1045856007463 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 1045856007464 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 1045856007465 molybdopterin cofactor binding site; other site 1045856007466 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1045856007467 aromatic amino acid exporter; Provisional; Region: PRK11689 1045856007468 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1045856007469 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 1045856007470 trimer interface [polypeptide binding]; other site 1045856007471 eyelet of channel; other site 1045856007472 Uncharacterized conserved protein [Function unknown]; Region: COG3791 1045856007473 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 1045856007474 TetR family transcriptional regulator; Provisional; Region: PRK14996 1045856007475 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1045856007476 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 1045856007477 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 1045856007478 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 1045856007479 [4Fe-4S] binding site [ion binding]; other site 1045856007480 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1045856007481 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1045856007482 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1045856007483 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 1045856007484 molybdopterin cofactor binding site; other site 1045856007485 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 1045856007486 nitrate reductase 2 subunit delta; Provisional; Region: PRK15054 1045856007487 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959 1045856007488 N-hydroxyarylamine O-acetyltransferase; Provisional; Region: PRK15047 1045856007489 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 1045856007490 elongation factor G; Reviewed; Region: PRK00007 1045856007491 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1045856007492 G1 box; other site 1045856007493 putative GEF interaction site [polypeptide binding]; other site 1045856007494 GTP/Mg2+ binding site [chemical binding]; other site 1045856007495 Switch I region; other site 1045856007496 G2 box; other site 1045856007497 G3 box; other site 1045856007498 Switch II region; other site 1045856007499 G4 box; other site 1045856007500 G5 box; other site 1045856007501 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1045856007502 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1045856007503 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1045856007504 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1045856007505 dimerization interface [polypeptide binding]; other site 1045856007506 putative DNA binding site [nucleotide binding]; other site 1045856007507 4-oxalocrotonate tautomerase; Provisional; Region: PRK01271 1045856007508 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1045856007509 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 1045856007510 C-terminal domain interface [polypeptide binding]; other site 1045856007511 GSH binding site (G-site) [chemical binding]; other site 1045856007512 dimer interface [polypeptide binding]; other site 1045856007513 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 1045856007514 N-terminal domain interface [polypeptide binding]; other site 1045856007515 dimer interface [polypeptide binding]; other site 1045856007516 substrate binding pocket (H-site) [chemical binding]; other site 1045856007517 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1045856007518 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1045856007519 substrate binding pocket [chemical binding]; other site 1045856007520 membrane-bound complex binding site; other site 1045856007521 hinge residues; other site 1045856007522 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1045856007523 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1045856007524 Walker A/P-loop; other site 1045856007525 ATP binding site [chemical binding]; other site 1045856007526 Q-loop/lid; other site 1045856007527 ABC transporter signature motif; other site 1045856007528 Walker B; other site 1045856007529 D-loop; other site 1045856007530 H-loop/switch region; other site 1045856007531 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1045856007532 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1045856007533 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1045856007534 dimer interface [polypeptide binding]; other site 1045856007535 conserved gate region; other site 1045856007536 putative PBP binding loops; other site 1045856007537 ABC-ATPase subunit interface; other site 1045856007538 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1045856007539 Coenzyme A binding pocket [chemical binding]; other site 1045856007540 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1045856007541 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1045856007542 substrate binding pocket [chemical binding]; other site 1045856007543 membrane-bound complex binding site; other site 1045856007544 hinge residues; other site 1045856007545 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 1045856007546 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 1045856007547 active site 1045856007548 non-prolyl cis peptide bond; other site 1045856007549 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1045856007550 M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669 1045856007551 metal binding site [ion binding]; metal-binding site 1045856007552 dimer interface [polypeptide binding]; other site 1045856007553 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1045856007554 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1045856007555 AAA domain; Region: AAA_17; pfam13207 1045856007556 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1045856007557 PAS domain; Region: PAS_9; pfam13426 1045856007558 putative active site [active] 1045856007559 heme pocket [chemical binding]; other site 1045856007560 HAMP domain; Region: HAMP; pfam00672 1045856007561 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1045856007562 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1045856007563 dimer interface [polypeptide binding]; other site 1045856007564 putative CheW interface [polypeptide binding]; other site 1045856007565 L-asparagine permease; Provisional; Region: PRK15049 1045856007566 PQQ-like domain; Region: PQQ_2; pfam13360 1045856007567 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1045856007568 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1045856007569 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1045856007570 N-terminal plug; other site 1045856007571 ligand-binding site [chemical binding]; other site 1045856007572 colanic acid/biofilm transcriptional regulator; Provisional; Region: PRK11414 1045856007573 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1045856007574 DNA-binding site [nucleotide binding]; DNA binding site 1045856007575 FCD domain; Region: FCD; pfam07729 1045856007576 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 1045856007577 Prostaglandin dehydrogenases; Region: PGDH; cd05288 1045856007578 NAD(P) binding site [chemical binding]; other site 1045856007579 substrate binding site [chemical binding]; other site 1045856007580 dimer interface [polypeptide binding]; other site 1045856007581 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1045856007582 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1045856007583 non-specific DNA binding site [nucleotide binding]; other site 1045856007584 salt bridge; other site 1045856007585 sequence-specific DNA binding site [nucleotide binding]; other site 1045856007586 Cupin domain; Region: Cupin_2; pfam07883 1045856007587 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1045856007588 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1045856007589 Coenzyme A binding pocket [chemical binding]; other site 1045856007590 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 1045856007591 Protein of unknown function (DUF2526); Region: DUF2526; pfam10735 1045856007592 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1045856007593 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 1045856007594 peptide binding site [polypeptide binding]; other site 1045856007595 Virulence factor SrfB; Region: SrfB; pfam07520 1045856007596 Uncharacterized protein conserved in bacteria, putative virulence factor [Function unknown]; Region: SrfC; COG4458 1045856007597 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1045856007598 Protein of unknown function (DUF2566); Region: DUF2566; pfam10753 1045856007599 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 1045856007600 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 1045856007601 tetrameric interface [polypeptide binding]; other site 1045856007602 NAD binding site [chemical binding]; other site 1045856007603 catalytic residues [active] 1045856007604 substrate binding site [chemical binding]; other site 1045856007605 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1045856007606 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1045856007607 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 1045856007608 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1045856007609 dimer interface [polypeptide binding]; other site 1045856007610 conserved gate region; other site 1045856007611 putative PBP binding loops; other site 1045856007612 ABC-ATPase subunit interface; other site 1045856007613 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1045856007614 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1045856007615 Walker A/P-loop; other site 1045856007616 ATP binding site [chemical binding]; other site 1045856007617 Q-loop/lid; other site 1045856007618 ABC transporter signature motif; other site 1045856007619 Walker B; other site 1045856007620 D-loop; other site 1045856007621 H-loop/switch region; other site 1045856007622 TOBE domain; Region: TOBE_2; pfam08402 1045856007623 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1045856007624 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1045856007625 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1045856007626 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1045856007627 DNA-binding site [nucleotide binding]; DNA binding site 1045856007628 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1045856007629 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1045856007630 homodimer interface [polypeptide binding]; other site 1045856007631 catalytic residue [active] 1045856007632 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 1045856007633 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1045856007634 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1045856007635 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1045856007636 Protein of unknown function (DUF2474); Region: DUF2474; pfam10617 1045856007637 heat-inducible protein; Provisional; Region: PRK10449 1045856007638 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 1045856007639 Domain of unknown function (DUF333); Region: DUF333; pfam03891 1045856007640 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 1045856007641 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 1045856007642 dimer interface [polypeptide binding]; other site 1045856007643 PYR/PP interface [polypeptide binding]; other site 1045856007644 TPP binding site [chemical binding]; other site 1045856007645 substrate binding site [chemical binding]; other site 1045856007646 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 1045856007647 Domain of unknown function; Region: EKR; smart00890 1045856007648 4Fe-4S binding domain; Region: Fer4_6; pfam12837 1045856007649 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1045856007650 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 1045856007651 TPP-binding site [chemical binding]; other site 1045856007652 dimer interface [polypeptide binding]; other site 1045856007653 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1045856007654 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 1045856007655 trimer interface [polypeptide binding]; other site 1045856007656 eyelet of channel; other site 1045856007657 Uncharacterized conserved protein [Function unknown]; Region: COG3791 1045856007658 Protein of unknown function (DUF1294); Region: DUF1294; pfam06961 1045856007659 hypothetical protein; Provisional; Region: PRK09951 1045856007660 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 1045856007661 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 1045856007662 active site 1045856007663 DNA binding site [nucleotide binding] 1045856007664 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 1045856007665 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 1045856007666 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1045856007667 Catalytic site [active] 1045856007668 Chaperone of endosialidase; Region: Peptidase_S74; pfam13884 1045856007669 Chaperone of endosialidase; Region: Peptidase_S74; pfam13884 1045856007670 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1045856007671 Interdomain contacts; other site 1045856007672 Cytokine receptor motif; other site 1045856007673 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 1045856007674 Fibronectin type III protein; Region: DUF3672; pfam12421 1045856007675 Terminase small subunit; Region: Terminase_2; pfam03592 1045856007676 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 1045856007677 catalytic residues [active] 1045856007678 Lysis protein S; Region: Lysis_S; pfam04971 1045856007679 Antitermination protein; Region: Antiterm; pfam03589 1045856007680 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1045856007681 Antitermination protein; Region: Antiterm; pfam03589 1045856007682 Protein of unknown function (DUF1367); Region: DUF1367; pfam07105 1045856007683 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1045856007684 Putative glucoamylase; Region: Glycoamylase; pfam10091 1045856007685 Second GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_2_like; cd11753 1045856007686 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 1045856007687 First GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_1_like; cd11756 1045856007688 Replication protein P; Region: Phage_lambda_P; pfam06992 1045856007689 Bacteriophage replication protein O; Region: Phage_rep_O; cl04545 1045856007690 Protein of unknown function (DUF1019); Region: DUF1019; pfam06254 1045856007691 Enterobacterial exodeoxyribonuclease VIII; Region: Exonuc_VIII; pfam06630 1045856007692 Domain of unknown function (DUF3596); Region: DUF3596; pfam12167 1045856007693 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1045856007694 phiCTX phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various phage and bacterial integrases, including those similar to phage integrases: Bordetella and...; Region: INT_phiCTX_C; cd01191 1045856007695 Int/Topo IB signature motif; other site 1045856007696 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 1045856007697 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 1045856007698 Ligand Binding Site [chemical binding]; other site 1045856007699 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 1045856007700 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1045856007701 ATP binding site [chemical binding]; other site 1045856007702 Mg++ binding site [ion binding]; other site 1045856007703 motif III; other site 1045856007704 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1045856007705 nucleotide binding region [chemical binding]; other site 1045856007706 ATP-binding site [chemical binding]; other site 1045856007707 RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501 1045856007708 putative RNA binding site [nucleotide binding]; other site 1045856007709 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1045856007710 Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; Region: ZntB-like_1; cd12833 1045856007711 Cl binding site [ion binding]; other site 1045856007712 oligomer interface [polypeptide binding]; other site 1045856007713 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1045856007714 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1045856007715 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1045856007716 dimer interface [polypeptide binding]; other site 1045856007717 putative CheW interface [polypeptide binding]; other site 1045856007718 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 1045856007719 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 1045856007720 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 1045856007721 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1045856007722 metal binding site [ion binding]; metal-binding site 1045856007723 active site 1045856007724 I-site; other site 1045856007725 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1045856007726 PAS domain S-box; Region: sensory_box; TIGR00229 1045856007727 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1045856007728 putative active site [active] 1045856007729 heme pocket [chemical binding]; other site 1045856007730 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1045856007731 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1045856007732 metal binding site [ion binding]; metal-binding site 1045856007733 active site 1045856007734 I-site; other site 1045856007735 intracellular protease, PfpI family; Region: PfpI; TIGR01382 1045856007736 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 1045856007737 conserved cys residue [active] 1045856007738 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 1045856007739 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1045856007740 peptide binding site [polypeptide binding]; other site 1045856007741 Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866 1045856007742 Peptidase M14-like domain of Escherichia coli Murein Peptide Amidase A and related proteins; Region: M14_MpaA_like; cd06904 1045856007743 putative active site [active] 1045856007744 Zn binding site [ion binding]; other site 1045856007745 L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129 1045856007746 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 1045856007747 active site 1045856007748 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 1045856007749 dimer interface [polypeptide binding]; other site 1045856007750 catalytic triad [active] 1045856007751 peroxidatic and resolving cysteines [active] 1045856007752 Aldose 1-epimerase, similar to Escherichia coli c4013; Region: Aldose_epim_Ec_c4013; cd09023 1045856007753 active site 1045856007754 catalytic residues [active] 1045856007755 DNA-binding transcriptional regulator TyrR; Provisional; Region: PRK10820 1045856007756 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1045856007757 PAS domain; Region: PAS; smart00091 1045856007758 putative active site [active] 1045856007759 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1045856007760 Walker A motif; other site 1045856007761 ATP binding site [chemical binding]; other site 1045856007762 Walker B motif; other site 1045856007763 arginine finger; other site 1045856007764 hypothetical protein; Provisional; Region: PRK05415 1045856007765 Domain of unknown function (DUF697); Region: DUF697; cl12064 1045856007766 Predicted ATPase [General function prediction only]; Region: COG3106 1045856007767 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1045856007768 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1045856007769 DNA binding site [nucleotide binding] 1045856007770 domain linker motif; other site 1045856007771 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1045856007772 Outer membrane protein G (OmpG); Region: Porin_OmpG; pfam09381 1045856007773 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 1045856007774 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1045856007775 Walker A/P-loop; other site 1045856007776 ATP binding site [chemical binding]; other site 1045856007777 Q-loop/lid; other site 1045856007778 ABC transporter signature motif; other site 1045856007779 Walker B; other site 1045856007780 D-loop; other site 1045856007781 H-loop/switch region; other site 1045856007782 TOBE domain; Region: TOBE_2; pfam08402 1045856007783 beta-phosphoglucomutase; Region: bPGM; TIGR01990 1045856007784 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1045856007785 motif II; other site 1045856007786 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 1045856007787 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 1045856007788 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 1045856007789 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 1045856007790 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1045856007791 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1045856007792 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1045856007793 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1045856007794 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1045856007795 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 1045856007796 putative NAD(P) binding site [chemical binding]; other site 1045856007797 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1045856007798 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1045856007799 dimer interface [polypeptide binding]; other site 1045856007800 conserved gate region; other site 1045856007801 putative PBP binding loops; other site 1045856007802 ABC-ATPase subunit interface; other site 1045856007803 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1045856007804 dimer interface [polypeptide binding]; other site 1045856007805 conserved gate region; other site 1045856007806 putative PBP binding loops; other site 1045856007807 ABC-ATPase subunit interface; other site 1045856007808 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1045856007809 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1045856007810 Alpha amylase catalytic domain found in sucrose phosphorylase-like proteins (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase-like_1; cd11356 1045856007811 sucrose phosphorylase; Region: sucrose_gtfA; TIGR03852 1045856007812 active site 1045856007813 homodimer interface [polypeptide binding]; other site 1045856007814 catalytic site [active] 1045856007815 peripheral inner membrane phage-shock protein; Provisional; Region: PRK10497 1045856007816 DNA-binding transcriptional activator PspC; Provisional; Region: PRK10697 1045856007817 phage shock protein C; Region: phageshock_pspC; TIGR02978 1045856007818 phage shock protein B; Provisional; Region: pspB; PRK09458 1045856007819 phage shock protein PspA; Provisional; Region: PRK10698 1045856007820 phage shock protein operon transcriptional activator; Provisional; Region: pspF; PRK11608 1045856007821 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1045856007822 Walker A motif; other site 1045856007823 ATP binding site [chemical binding]; other site 1045856007824 Walker B motif; other site 1045856007825 arginine finger; other site 1045856007826 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1045856007827 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 1045856007828 peptide binding site [polypeptide binding]; other site 1045856007829 antimicrobial peptide ABC transporter permease SapB; Provisional; Region: PRK15110 1045856007830 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1045856007831 dimer interface [polypeptide binding]; other site 1045856007832 conserved gate region; other site 1045856007833 putative PBP binding loops; other site 1045856007834 ABC-ATPase subunit interface; other site 1045856007835 antimicrobial peptide ABC transporter permease SapC; Provisional; Region: PRK15111 1045856007836 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1045856007837 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1045856007838 dimer interface [polypeptide binding]; other site 1045856007839 conserved gate region; other site 1045856007840 putative PBP binding loops; other site 1045856007841 ABC-ATPase subunit interface; other site 1045856007842 antimicrobial peptide ABC transporter ATP-binding protein; Provisional; Region: PRK15093 1045856007843 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1045856007844 Walker A/P-loop; other site 1045856007845 ATP binding site [chemical binding]; other site 1045856007846 Q-loop/lid; other site 1045856007847 ABC transporter signature motif; other site 1045856007848 Walker B; other site 1045856007849 D-loop; other site 1045856007850 H-loop/switch region; other site 1045856007851 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1045856007852 antimicrobial peptide ABC system ATP-binding protein SapF; Provisional; Region: PRK15112 1045856007853 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1045856007854 Walker A/P-loop; other site 1045856007855 ATP binding site [chemical binding]; other site 1045856007856 Q-loop/lid; other site 1045856007857 ABC transporter signature motif; other site 1045856007858 Walker B; other site 1045856007859 D-loop; other site 1045856007860 H-loop/switch region; other site 1045856007861 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1045856007862 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1045856007863 YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgH_like; cd02198 1045856007864 homotrimer interaction site [polypeptide binding]; other site 1045856007865 putative active site [active] 1045856007866 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1045856007867 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1045856007868 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1045856007869 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1045856007870 metal binding site [ion binding]; metal-binding site 1045856007871 active site 1045856007872 I-site; other site 1045856007873 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1045856007874 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1045856007875 PgaD-like protein; Region: PgaD; cl14676 1045856007876 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07984 1045856007877 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 1045856007878 NAD binding site [chemical binding]; other site 1045856007879 homotetramer interface [polypeptide binding]; other site 1045856007880 homodimer interface [polypeptide binding]; other site 1045856007881 substrate binding site [chemical binding]; other site 1045856007882 active site 1045856007883 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950 1045856007884 exoribonuclease II; Provisional; Region: PRK05054 1045856007885 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 1045856007886 RNB domain; Region: RNB; pfam00773 1045856007887 S1 RNA binding domain; Region: S1; pfam00575 1045856007888 RNase II stability modulator; Provisional; Region: PRK10060 1045856007889 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1045856007890 putative active site [active] 1045856007891 heme pocket [chemical binding]; other site 1045856007892 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1045856007893 metal binding site [ion binding]; metal-binding site 1045856007894 active site 1045856007895 I-site; other site 1045856007896 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1045856007897 enoyl-CoA hydratase; Validated; Region: PRK08788 1045856007898 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1045856007899 substrate binding site [chemical binding]; other site 1045856007900 oxyanion hole (OAH) forming residues; other site 1045856007901 trimer interface [polypeptide binding]; other site 1045856007902 hypothetical protein; Provisional; Region: PRK13658 1045856007903 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1045856007904 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1045856007905 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1045856007906 lipoprotein; Provisional; Region: PRK10540 1045856007907 translation initiation factor Sui1; Validated; Region: PRK06824 1045856007908 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 1045856007909 putative rRNA binding site [nucleotide binding]; other site 1045856007910 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1045856007911 active site 1045856007912 dimer interface [polypeptide binding]; other site 1045856007913 tetratricopeptide repeat protein; Provisional; Region: PRK11788 1045856007914 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1045856007915 binding surface 1045856007916 TPR motif; other site 1045856007917 Predicted membrane protein [Function unknown]; Region: COG3771 1045856007918 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1045856007919 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 1045856007920 active site 1045856007921 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 1045856007922 dimerization interface [polypeptide binding]; other site 1045856007923 active site 1045856007924 aconitate hydratase; Validated; Region: PRK09277 1045856007925 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 1045856007926 substrate binding site [chemical binding]; other site 1045856007927 ligand binding site [chemical binding]; other site 1045856007928 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 1045856007929 substrate binding site [chemical binding]; other site 1045856007930 transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681 1045856007931 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1045856007932 The C-terminal substrate domain of LysR-type transcriptional regulator CysB contains type 2 periplasmic binding fold; Region: PBP2_CysB; cd08443 1045856007933 substrate binding site [chemical binding]; other site 1045856007934 putative dimerization interface [polypeptide binding]; other site 1045856007935 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 1045856007936 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1045856007937 active site 1045856007938 interdomain interaction site; other site 1045856007939 putative metal-binding site [ion binding]; other site 1045856007940 nucleotide binding site [chemical binding]; other site 1045856007941 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1045856007942 domain I; other site 1045856007943 DNA binding groove [nucleotide binding] 1045856007944 phosphate binding site [ion binding]; other site 1045856007945 domain II; other site 1045856007946 domain III; other site 1045856007947 nucleotide binding site [chemical binding]; other site 1045856007948 catalytic site [active] 1045856007949 domain IV; other site 1045856007950 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1045856007951 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1045856007952 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 1045856007953 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 1045856007954 hypothetical protein; Provisional; Region: PRK11037 1045856007955 Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496 1045856007956 putative inner membrane peptidase; Provisional; Region: PRK11778 1045856007957 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 1045856007958 tandem repeat interface [polypeptide binding]; other site 1045856007959 oligomer interface [polypeptide binding]; other site 1045856007960 active site residues [active] 1045856007961 putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945 1045856007962 Escherichia coli K-12 YCIK-like, classical (c) SDRs; Region: Ycik_SDR_c; cd05340 1045856007963 NADP binding site [chemical binding]; other site 1045856007964 homodimer interface [polypeptide binding]; other site 1045856007965 active site 1045856007966 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 1045856007967 cob(I)alamin adenolsyltransferase/cobinamide ATP-dependent adenolsyltransferase; Validated; Region: PRK05986 1045856007968 23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700 1045856007969 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1045856007970 RNA binding surface [nucleotide binding]; other site 1045856007971 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 1045856007972 probable active site [active] 1045856007973 hypothetical protein; Provisional; Region: PRK11630 1045856007974 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 1045856007975 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 1045856007976 active site 1045856007977 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 1045856007978 anthranilate synthase component I; Provisional; Region: PRK13564 1045856007979 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1045856007980 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1045856007981 bifunctional glutamine amidotransferase/anthranilate phosphoribosyltransferase; Provisional; Region: PRK09522 1045856007982 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1045856007983 glutamine binding [chemical binding]; other site 1045856007984 catalytic triad [active] 1045856007985 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1045856007986 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1045856007987 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427 1045856007988 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 1045856007989 active site 1045856007990 ribulose/triose binding site [chemical binding]; other site 1045856007991 phosphate binding site [ion binding]; other site 1045856007992 substrate (anthranilate) binding pocket [chemical binding]; other site 1045856007993 product (indole) binding pocket [chemical binding]; other site 1045856007994 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 1045856007995 active site 1045856007996 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 1045856007997 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1045856007998 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1045856007999 catalytic residue [active] 1045856008000 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 1045856008001 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 1045856008002 substrate binding site [chemical binding]; other site 1045856008003 active site 1045856008004 catalytic residues [active] 1045856008005 heterodimer interface [polypeptide binding]; other site 1045856008006 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1045856008007 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1045856008008 NAD(P) binding site [chemical binding]; other site 1045856008009 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 1045856008010 classical (c) SDRs; Region: SDR_c; cd05233 1045856008011 NAD(P) binding site [chemical binding]; other site 1045856008012 active site 1045856008013 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1045856008014 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1045856008015 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 1045856008016 dimerization interface [polypeptide binding]; other site 1045856008017 substrate binding pocket [chemical binding]; other site 1045856008018 ChrR Cupin-like domain; Region: Cupin_7; pfam12973 1045856008019 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1045856008020 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1045856008021 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 1045856008022 Uncharacterized conserved protein [Function unknown]; Region: COG4925 1045856008023 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 1045856008024 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 1045856008025 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1045856008026 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1045856008027 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1045856008028 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 1045856008029 putative effector binding pocket; other site 1045856008030 putative dimerization interface [polypeptide binding]; other site 1045856008031 short chain dehydrogenase; Provisional; Region: PRK06172 1045856008032 classical (c) SDRs; Region: SDR_c; cd05233 1045856008033 NAD(P) binding site [chemical binding]; other site 1045856008034 active site 1045856008035 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1045856008036 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1045856008037 active site 1045856008038 catalytic tetrad [active] 1045856008039 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1045856008040 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1045856008041 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1045856008042 DNA-binding site [nucleotide binding]; DNA binding site 1045856008043 RNA-binding motif; other site 1045856008044 Predicted protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: COG3531 1045856008045 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 1045856008046 catalytic residues [active] 1045856008047 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1045856008048 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1045856008049 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 1045856008050 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1045856008051 nucleophilic elbow; other site 1045856008052 catalytic triad; other site 1045856008053 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1045856008054 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1045856008055 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1045856008056 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1045856008057 short chain dehydrogenase; Provisional; Region: PRK06500 1045856008058 classical (c) SDRs; Region: SDR_c; cd05233 1045856008059 NAD(P) binding site [chemical binding]; other site 1045856008060 active site 1045856008061 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1045856008062 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1045856008063 DNA binding residues [nucleotide binding] 1045856008064 Mig-14; Region: Mig-14; pfam07395 1045856008065 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 1045856008066 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1045856008067 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1045856008068 dimerization interface [polypeptide binding]; other site 1045856008069 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1045856008070 dimer interface [polypeptide binding]; other site 1045856008071 phosphorylation site [posttranslational modification] 1045856008072 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1045856008073 ATP binding site [chemical binding]; other site 1045856008074 Mg2+ binding site [ion binding]; other site 1045856008075 G-X-G motif; other site 1045856008076 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1045856008077 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1045856008078 active site 1045856008079 phosphorylation site [posttranslational modification] 1045856008080 intermolecular recognition site; other site 1045856008081 dimerization interface [polypeptide binding]; other site 1045856008082 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1045856008083 DNA binding site [nucleotide binding] 1045856008084 MltA-interacting protein MipA; Region: MipA; cl01504 1045856008085 LysR substrate binding domain; Region: LysR_substrate; pfam03466 1045856008086 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1045856008087 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1045856008088 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1045856008089 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1045856008090 NAD(P) binding site [chemical binding]; other site 1045856008091 active site 1045856008092 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1045856008093 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1045856008094 NAD(P) binding site [chemical binding]; other site 1045856008095 active site 1045856008096 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1045856008097 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1045856008098 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 1045856008099 putative effector binding pocket; other site 1045856008100 putative dimerization interface [polypeptide binding]; other site 1045856008101 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1045856008102 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1045856008103 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1045856008104 putative effector binding pocket; other site 1045856008105 dimerization interface [polypeptide binding]; other site 1045856008106 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1045856008107 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1045856008108 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 1045856008109 putative NAD(P) binding site [chemical binding]; other site 1045856008110 short chain dehydrogenase; Provisional; Region: PRK06179 1045856008111 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1045856008112 NADP binding site [chemical binding]; other site 1045856008113 active site 1045856008114 steroid binding site; other site 1045856008115 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1045856008116 classical (c) SDRs; Region: SDR_c; cd05233 1045856008117 NAD(P) binding site [chemical binding]; other site 1045856008118 active site 1045856008119 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1045856008120 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1045856008121 putative inner membrane protein; Provisional; Region: PRK11099 1045856008122 Sulphur transport; Region: Sulf_transp; pfam04143 1045856008123 YedF is a bacterial SirA-like protein of unknown function. SirA (also known as UvrY, and YhhP) belongs to a family of a two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system...; Region: YedF; cd03422 1045856008124 CPxP motif; other site 1045856008125 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1045856008126 Ligand Binding Site [chemical binding]; other site 1045856008127 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 1045856008128 outer membrane protein W; Provisional; Region: PRK10959 1045856008129 hypothetical protein; Provisional; Region: PRK02868 1045856008130 intracellular septation protein A; Reviewed; Region: PRK00259 1045856008131 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 1045856008132 transport protein TonB; Provisional; Region: PRK10819 1045856008133 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 1045856008134 YciI-like protein; Reviewed; Region: PRK11370 1045856008135 leucine export protein LeuE; Provisional; Region: PRK10958 1045856008136 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 1045856008137 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 1045856008138 Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152 1045856008139 putative active site [active] 1045856008140 catalytic site [active] 1045856008141 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158 1045856008142 putative active site [active] 1045856008143 catalytic site [active] 1045856008144 dsDNA-mimic protein; Reviewed; Region: PRK05094 1045856008145 Ion transport protein; Region: Ion_trans; pfam00520 1045856008146 Ion channel; Region: Ion_trans_2; pfam07885 1045856008147 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 1045856008148 Double zinc ribbon; Region: DZR; pfam12773 1045856008149 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 1045856008150 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1045856008151 Walker A/P-loop; other site 1045856008152 ATP binding site [chemical binding]; other site 1045856008153 Q-loop/lid; other site 1045856008154 ABC transporter signature motif; other site 1045856008155 Walker B; other site 1045856008156 D-loop; other site 1045856008157 H-loop/switch region; other site 1045856008158 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1045856008159 oligopeptide transporter ATP-binding component; Provisional; Region: oppD; PRK09473 1045856008160 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1045856008161 Walker A/P-loop; other site 1045856008162 ATP binding site [chemical binding]; other site 1045856008163 Q-loop/lid; other site 1045856008164 ABC transporter signature motif; other site 1045856008165 Walker B; other site 1045856008166 D-loop; other site 1045856008167 H-loop/switch region; other site 1045856008168 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1045856008169 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 1045856008170 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1045856008171 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1045856008172 dimer interface [polypeptide binding]; other site 1045856008173 conserved gate region; other site 1045856008174 putative PBP binding loops; other site 1045856008175 ABC-ATPase subunit interface; other site 1045856008176 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 1045856008177 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1045856008178 dimer interface [polypeptide binding]; other site 1045856008179 conserved gate region; other site 1045856008180 putative PBP binding loops; other site 1045856008181 ABC-ATPase subunit interface; other site 1045856008182 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 1045856008183 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1045856008184 peptide binding site [polypeptide binding]; other site 1045856008185 hypothetical protein; Provisional; Region: PRK11111 1045856008186 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 1045856008187 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 1045856008188 putative catalytic cysteine [active] 1045856008189 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 1045856008190 putative active site [active] 1045856008191 metal binding site [ion binding]; metal-binding site 1045856008192 thymidine kinase; Provisional; Region: PRK04296 1045856008193 global DNA-binding transcriptional dual regulator H-NS; Provisional; Region: PRK10947 1045856008194 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 1045856008195 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1045856008196 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1045856008197 active site 1045856008198 tetramer interface; other site 1045856008199 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1045856008200 active site 1045856008201 response regulator of RpoS; Provisional; Region: PRK10693 1045856008202 phosphorylation site [posttranslational modification] 1045856008203 intermolecular recognition site; other site 1045856008204 dimerization interface [polypeptide binding]; other site 1045856008205 hypothetical protein; Provisional; Region: PRK10279 1045856008206 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 1045856008207 active site 1045856008208 nucleophile elbow; other site 1045856008209 SEC-C motif; Region: SEC-C; pfam02810 1045856008210 hypothetical protein; Provisional; Region: PRK04233 1045856008211 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 1045856008212 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 1045856008213 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 1045856008214 putative active site [active] 1045856008215 putative substrate binding site [chemical binding]; other site 1045856008216 putative cosubstrate binding site; other site 1045856008217 catalytic site [active] 1045856008218 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1045856008219 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 1045856008220 putative DNA binding site [nucleotide binding]; other site 1045856008221 putative Zn2+ binding site [ion binding]; other site 1045856008222 AsnC family; Region: AsnC_trans_reg; pfam01037 1045856008223 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1045856008224 EamA-like transporter family; Region: EamA; pfam00892 1045856008225 EamA-like transporter family; Region: EamA; pfam00892 1045856008226 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 1045856008227 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1045856008228 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1045856008229 active site 1045856008230 Glycosyl transferase family 21; Region: Glyco_transf_21; pfam13506 1045856008231 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 1045856008232 extended (e) SDRs; Region: SDR_e; cd08946 1045856008233 3-beta hydroxysteroid dehydrogenase/isomerase family; Region: 3Beta_HSD; pfam01073 1045856008234 NAD(P) binding site [chemical binding]; other site 1045856008235 active site 1045856008236 substrate binding site [chemical binding]; other site 1045856008237 Fatty acid desaturase; Region: FA_desaturase; pfam00487 1045856008238 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 1045856008239 putative di-iron ligands [ion binding]; other site 1045856008240 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 1045856008241 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 1045856008242 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 1045856008243 active site 1045856008244 putative adenylate-forming enzyme; Region: aden_form_hyp; TIGR02304 1045856008245 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 1045856008246 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 1045856008247 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1045856008248 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1045856008249 NAD(P) binding site [chemical binding]; other site 1045856008250 active site 1045856008251 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK07204 1045856008252 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1045856008253 dimer interface [polypeptide binding]; other site 1045856008254 active site 1045856008255 CoA binding pocket [chemical binding]; other site 1045856008256 respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351 1045856008257 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 1045856008258 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 1045856008259 4Fe-4S binding domain; Region: Fer4; cl02805 1045856008260 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 1045856008261 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 1045856008262 [4Fe-4S] binding site [ion binding]; other site 1045856008263 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1045856008264 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1045856008265 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1045856008266 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 1045856008267 molybdopterin cofactor binding site; other site 1045856008268 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 1045856008269 nitrate/nitrite sensor protein NarX; Provisional; Region: PRK10600 1045856008270 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 1045856008271 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1045856008272 dimerization interface [polypeptide binding]; other site 1045856008273 Histidine kinase; Region: HisKA_3; pfam07730 1045856008274 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1045856008275 ATP binding site [chemical binding]; other site 1045856008276 Mg2+ binding site [ion binding]; other site 1045856008277 G-X-G motif; other site 1045856008278 transcriptional regulator NarL; Provisional; Region: PRK10651 1045856008279 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1045856008280 active site 1045856008281 phosphorylation site [posttranslational modification] 1045856008282 intermolecular recognition site; other site 1045856008283 dimerization interface [polypeptide binding]; other site 1045856008284 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1045856008285 DNA binding residues [nucleotide binding] 1045856008286 dimerization interface [polypeptide binding]; other site 1045856008287 putative invasin; Provisional; Region: PRK10177 1045856008288 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 1045856008289 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 1045856008290 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 1045856008291 [4Fe-4S] binding site [ion binding]; other site 1045856008292 molybdopterin cofactor binding site; other site 1045856008293 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 1045856008294 molybdopterin cofactor binding site; other site 1045856008295 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1045856008296 NADH:flavorubredoxin oxidoreductase; Provisional; Region: PRK04965 1045856008297 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1045856008298 nitrite reductase subunit NirD; Provisional; Region: PRK14989 1045856008299 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1045856008300 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1045856008301 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1045856008302 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 1045856008303 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1045856008304 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1045856008305 Walker A/P-loop; other site 1045856008306 ATP binding site [chemical binding]; other site 1045856008307 Q-loop/lid; other site 1045856008308 ABC transporter signature motif; other site 1045856008309 Walker B; other site 1045856008310 D-loop; other site 1045856008311 H-loop/switch region; other site 1045856008312 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1045856008313 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1045856008314 dimer interface [polypeptide binding]; other site 1045856008315 conserved gate region; other site 1045856008316 putative PBP binding loops; other site 1045856008317 ABC-ATPase subunit interface; other site 1045856008318 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1045856008319 NMT1-like family; Region: NMT1_2; pfam13379 1045856008320 Nitrate and nitrite sensing; Region: NIT; pfam08376 1045856008321 ANTAR domain; Region: ANTAR; pfam03861 1045856008322 Uncharacterized conserved protein involved in intracellular sulfur reduction [Inorganic ion transport and metabolism]; Region: DsrE; COG1553 1045856008323 Cache domain; Region: Cache_1; pfam02743 1045856008324 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1045856008325 dimerization interface [polypeptide binding]; other site 1045856008326 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1045856008327 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1045856008328 dimer interface [polypeptide binding]; other site 1045856008329 putative CheW interface [polypeptide binding]; other site 1045856008330 Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703 1045856008331 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1045856008332 putative active site pocket [active] 1045856008333 dimerization interface [polypeptide binding]; other site 1045856008334 putative catalytic residue [active] 1045856008335 cation transport regulator; Reviewed; Region: chaB; PRK09582 1045856008336 calcium/sodium:proton antiporter; Provisional; Region: PRK10599 1045856008337 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1045856008338 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 1045856008339 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1045856008340 hypothetical protein; Provisional; Region: PRK10941 1045856008341 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 1045856008342 hypothetical protein; Provisional; Region: PRK10278 1045856008343 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 1045856008344 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1045856008345 peptide chain release factor 1; Validated; Region: prfA; PRK00591 1045856008346 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1045856008347 RF-1 domain; Region: RF-1; pfam00472 1045856008348 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 1045856008349 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 1045856008350 tRNA; other site 1045856008351 putative tRNA binding site [nucleotide binding]; other site 1045856008352 putative NADP binding site [chemical binding]; other site 1045856008353 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 1045856008354 outer membrane lipoprotein LolB; Provisional; Region: lolB; PRK00022 1045856008355 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 1045856008356 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 1045856008357 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1045856008358 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1045856008359 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 1045856008360 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1045856008361 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1045856008362 active site 1045856008363 putative transporter; Provisional; Region: PRK11660 1045856008364 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1045856008365 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1045856008366 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1045856008367 Helix-Turn-Helix DNA binding domain of the transcription regulators NolA and AlbR; Region: HTH_NolA-AlbR; cd04788 1045856008368 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1045856008369 DNA binding residues [nucleotide binding] 1045856008370 putative dimer interface [polypeptide binding]; other site 1045856008371 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 1045856008372 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 1045856008373 hypothetical protein; Provisional; Region: PRK10692 1045856008374 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1045856008375 putative active site [active] 1045856008376 catalytic residue [active] 1045856008377 GTP-binding protein YchF; Reviewed; Region: PRK09601 1045856008378 YchF GTPase; Region: YchF; cd01900 1045856008379 G1 box; other site 1045856008380 GTP/Mg2+ binding site [chemical binding]; other site 1045856008381 Switch I region; other site 1045856008382 G2 box; other site 1045856008383 Switch II region; other site 1045856008384 G3 box; other site 1045856008385 G4 box; other site 1045856008386 G5 box; other site 1045856008387 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 1045856008388 Macro domain, Poa1p_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Poa1p_like; cd02901 1045856008389 ADP-ribose binding site [chemical binding]; other site 1045856008390 RHS protein; Region: RHS; pfam03527 1045856008391 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1045856008392 YCII-related domain; Region: YCII; cl00999 1045856008393 The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information...; Region: TGS; cl15768 1045856008394 RHS protein; Region: RHS; pfam03527 1045856008395 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1045856008396 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1045856008397 binding surface 1045856008398 TPR motif; other site 1045856008399 PAAR motif; Region: PAAR_motif; pfam05488 1045856008400 RHS Repeat; Region: RHS_repeat; pfam05593 1045856008401 RHS Repeat; Region: RHS_repeat; pfam05593 1045856008402 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1045856008403 RHS Repeat; Region: RHS_repeat; pfam05593 1045856008404 RHS Repeat; Region: RHS_repeat; pfam05593 1045856008405 RHS Repeat; Region: RHS_repeat; pfam05593 1045856008406 RHS Repeat; Region: RHS_repeat; pfam05593 1045856008407 RHS Repeat; Region: RHS_repeat; pfam05593 1045856008408 RHS protein; Region: RHS; pfam03527 1045856008409 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1045856008410 Domain of unknown function (DUF1795); Region: DUF1795; pfam08786 1045856008411 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 1045856008412 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 1045856008413 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 1045856008414 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 1045856008415 PAAR motif; Region: PAAR_motif; pfam05488 1045856008416 VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of...; Region: VIP2; cl00173 1045856008417 active site 1045856008418 conformational flexibility of ligand binding pocket; other site 1045856008419 ADP-ribosylating toxin turn-turn motif; other site 1045856008420 Domain of unknown function (DUF1795); Region: DUF1795; pfam08786 1045856008421 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 1045856008422 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 1045856008423 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 1045856008424 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1045856008425 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1045856008426 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1045856008427 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1045856008428 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1045856008429 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1045856008430 active site 1045856008431 ATP binding site [chemical binding]; other site 1045856008432 substrate binding site [chemical binding]; other site 1045856008433 activation loop (A-loop); other site 1045856008434 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 1045856008435 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1045856008436 Walker A motif; other site 1045856008437 ATP binding site [chemical binding]; other site 1045856008438 Walker B motif; other site 1045856008439 arginine finger; other site 1045856008440 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1045856008441 Walker A motif; other site 1045856008442 ATP binding site [chemical binding]; other site 1045856008443 Walker B motif; other site 1045856008444 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1045856008445 Protein of unknown function (DUF1305); Region: DUF1305; pfam06996 1045856008446 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 1045856008447 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 1045856008448 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 1045856008449 Protein of avirulence locus involved in temperature-dependent protein secretion [General function prediction only]; Region: ImpE; COG4455 1045856008450 ImpE protein; Region: ImpE; pfam07024 1045856008451 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1045856008452 active site 1045856008453 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1045856008454 phosphopeptide binding site; other site 1045856008455 Protein of unknown function (DUF796); Region: DUF796; pfam05638 1045856008456 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517 1045856008457 Protein of unknown function (DUF877); Region: DUF877; pfam05943 1045856008458 Protein of unknown function (DUF770); Region: DUF770; pfam05591 1045856008459 type VI secretion-associated protein, ImpA family; Region: VI_chp_8; TIGR03363 1045856008460 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 1045856008461 Uncharacterized protein conserved in bacteria (DUF2094); Region: DUF2094; pfam09867 1045856008462 type VI secretion protein IcmF; Region: VI_IcmF; TIGR03348 1045856008463 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 1045856008464 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 1045856008465 hypothetical protein; Provisional; Region: PRK07033 1045856008466 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850 1045856008467 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1045856008468 ligand binding site [chemical binding]; other site 1045856008469 type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353 1045856008470 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 1045856008471 Type VI secretion lipoprotein; Region: T6SS-SciN; pfam12790 1045856008472 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 1045856008473 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 1045856008474 putative molybdopterin cofactor binding site [chemical binding]; other site 1045856008475 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 1045856008476 putative molybdopterin cofactor binding site; other site 1045856008477 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1045856008478 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1045856008479 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1045856008480 dimerization interface [polypeptide binding]; other site 1045856008481 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 1045856008482 Fatty acid desaturase protein family subgroup, a delta-12 acyl-lipid desaturase-like, DesA-like, yet uncharacterized subgroup of membrane fatty acid desaturase proteins found in alpha-, beta-, and gamma-proteobacteria. Sequences of this domain family...; Region: DesA_FADS-like; cd03509 1045856008483 Fatty acid desaturase; Region: FA_desaturase; pfam00487 1045856008484 putative di-iron ligands [ion binding]; other site 1045856008485 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1045856008486 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 1045856008487 conserved cys residue [active] 1045856008488 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1045856008489 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1045856008490 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 1045856008491 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 1045856008492 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1045856008493 ribonucleoside transporter; Reviewed; Region: nepI; PRK10213 1045856008494 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1045856008495 putative substrate translocation pore; other site 1045856008496 Cupin; Region: Cupin_6; pfam12852 1045856008497 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1045856008498 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1045856008499 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1045856008500 trehalase; Provisional; Region: treA; PRK13271 1045856008501 Neutral trehalase [Carbohydrate transport and metabolism]; Region: TreA; COG1626 1045856008502 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 1045856008503 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1045856008504 N-terminal plug; other site 1045856008505 ligand-binding site [chemical binding]; other site 1045856008506 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 1045856008507 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 1045856008508 Flagellar regulator YcgR; Region: YcgR; pfam07317 1045856008509 PilZ domain; Region: PilZ; pfam07238 1045856008510 lytic murein endotransglycosylase E; Provisional; Region: emtA; PRK15470 1045856008511 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1045856008512 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1045856008513 catalytic residue [active] 1045856008514 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 1045856008515 dimer interface [polypeptide binding]; other site 1045856008516 catalytic triad [active] 1045856008517 NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain [Inorganic ion transport and metabolism]; Region: COG3263 1045856008518 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 1045856008519 TrkA-C domain; Region: TrkA_C; pfam02080 1045856008520 Transporter associated domain; Region: CorC_HlyC; smart01091 1045856008521 alanine racemase; Reviewed; Region: dadX; PRK03646 1045856008522 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 1045856008523 active site 1045856008524 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1045856008525 substrate binding site [chemical binding]; other site 1045856008526 catalytic residues [active] 1045856008527 dimer interface [polypeptide binding]; other site 1045856008528 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 1045856008529 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1045856008530 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1045856008531 SpoVR family protein; Provisional; Region: PRK11767 1045856008532 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 1045856008533 fatty acid metabolism regulator; Provisional; Region: PRK04984 1045856008534 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1045856008535 DNA-binding site [nucleotide binding]; DNA binding site 1045856008536 FadR C-terminal domain; Region: FadR_C; pfam07840 1045856008537 sodium/proton antiporter; Reviewed; Region: nhaB; PRK09547 1045856008538 disulfide bond formation protein B; Provisional; Region: PRK01749 1045856008539 hypothetical protein; Provisional; Region: PRK05170 1045856008540 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1045856008541 hypothetical protein; Provisional; Region: PRK10691 1045856008542 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3100 1045856008543 septum formation inhibitor; Reviewed; Region: minC; PRK03511 1045856008544 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 1045856008545 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 1045856008546 cell division inhibitor MinD; Provisional; Region: PRK10818 1045856008547 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 1045856008548 Switch I; other site 1045856008549 Switch II; other site 1045856008550 cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296 1045856008551 ribonuclease D; Provisional; Region: PRK10829 1045856008552 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 1045856008553 catalytic site [active] 1045856008554 putative active site [active] 1045856008555 putative substrate binding site [chemical binding]; other site 1045856008556 Helicase and RNase D C-terminal; Region: HRDC; smart00341 1045856008557 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974 1045856008558 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1045856008559 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 1045856008560 acyl-activating enzyme (AAE) consensus motif; other site 1045856008561 putative AMP binding site [chemical binding]; other site 1045856008562 putative active site [active] 1045856008563 putative CoA binding site [chemical binding]; other site 1045856008564 Starvation-inducible outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: Slp; COG3065 1045856008565 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1045856008566 Glycoprotease family; Region: Peptidase_M22; pfam00814 1045856008567 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 1045856008568 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1045856008569 ATP binding site [chemical binding]; other site 1045856008570 DEAD_2; Region: DEAD_2; pfam06733 1045856008571 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1045856008572 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 1045856008573 homotrimer interaction site [polypeptide binding]; other site 1045856008574 putative active site [active] 1045856008575 hypothetical protein; Provisional; Region: PRK05114 1045856008576 aminodeoxychorismate synthase subunit I; Provisional; Region: pabB; PRK15465 1045856008577 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1045856008578 chorismate binding enzyme; Region: Chorismate_bind; cl10555 1045856008579 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 1045856008580 putative active site [active] 1045856008581 putative CoA binding site [chemical binding]; other site 1045856008582 nudix motif; other site 1045856008583 metal binding site [ion binding]; metal-binding site 1045856008584 L-serine deaminase; Provisional; Region: PRK15023 1045856008585 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1045856008586 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 1045856008587 phage resistance protein; Provisional; Region: PRK10551 1045856008588 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 1045856008589 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1045856008590 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 1045856008591 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1045856008592 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1045856008593 Transporter associated domain; Region: CorC_HlyC; smart01091 1045856008594 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 1045856008595 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 1045856008596 active pocket/dimerization site; other site 1045856008597 active site 1045856008598 phosphorylation site [posttranslational modification] 1045856008599 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 1045856008600 active site 1045856008601 phosphorylation site [posttranslational modification] 1045856008602 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 1045856008603 PTS system mannose-specific transporter subunit IID; Provisional; Region: PRK11103 1045856008604 hypothetical protein; Provisional; Region: PRK02913 1045856008605 hypothetical protein; Provisional; Region: PRK11469 1045856008606 Domain of unknown function DUF; Region: DUF204; pfam02659 1045856008607 Domain of unknown function DUF; Region: DUF204; pfam02659 1045856008608 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 1045856008609 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1045856008610 S-adenosylmethionine binding site [chemical binding]; other site 1045856008611 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 1045856008612 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1045856008613 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1045856008614 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1045856008615 DNA-binding site [nucleotide binding]; DNA binding site 1045856008616 RNA-binding motif; other site 1045856008617 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1045856008618 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 1045856008619 YebO-like protein; Region: YebO; pfam13974 1045856008620 PhoPQ regulatory protein; Provisional; Region: PRK10299 1045856008621 YobH-like protein; Region: YobH; pfam13996 1045856008622 DNA-binding transcriptional regulator KdgR; Provisional; Region: PRK15090 1045856008623 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1045856008624 dimerization interface [polypeptide binding]; other site 1045856008625 putative Zn2+ binding site [ion binding]; other site 1045856008626 putative DNA binding site [nucleotide binding]; other site 1045856008627 Bacterial transcriptional regulator; Region: IclR; pfam01614 1045856008628 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1045856008629 putative substrate translocation pore; other site 1045856008630 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1045856008631 heat shock protein HtpX; Provisional; Region: PRK05457 1045856008632 carboxy-terminal protease; Provisional; Region: PRK11186 1045856008633 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1045856008634 protein binding site [polypeptide binding]; other site 1045856008635 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 1045856008636 Catalytic dyad [active] 1045856008637 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 1045856008638 ProP expression regulator; Provisional; Region: PRK04950 1045856008639 ProQ/FINO family; Region: ProQ; pfam04352 1045856008640 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 1045856008641 GAF domain; Region: GAF_2; pfam13185 1045856008642 integral membrane protein, PqiA family; Region: pqiA_fam; TIGR00155 1045856008643 Paraquat-inducible protein A; Region: PqiA; pfam04403 1045856008644 Paraquat-inducible protein A; Region: PqiA; pfam04403 1045856008645 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 1045856008646 mce related protein; Region: MCE; pfam02470 1045856008647 mce related protein; Region: MCE; pfam02470 1045856008648 mce related protein; Region: MCE; pfam02470 1045856008649 mce related protein; Region: MCE; pfam02470 1045856008650 mce related protein; Region: MCE; pfam02470 1045856008651 mce related protein; Region: MCE; pfam02470 1045856008652 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 1045856008653 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1045856008654 S-adenosylmethionine binding site [chemical binding]; other site 1045856008655 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 1045856008656 Protein of unknown function (DUF1480); Region: DUF1480; pfam07351 1045856008657 serine/threonine protein phosphatase 1; Provisional; Region: pphA; PRK11439 1045856008658 Protein of unknown function (DUF535); Region: DUF535; pfam04393 1045856008659 Glycosyltransferase family 17; Region: Glyco_transf_17; pfam04724 1045856008660 Protein of unknown function (DUF2511); Region: DUF2511; pfam10709 1045856008661 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 1045856008662 CopC domain; Region: CopC; cl01012 1045856008663 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1045856008664 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 1045856008665 exodeoxyribonuclease X; Provisional; Region: PRK07983 1045856008666 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1045856008667 active site 1045856008668 catalytic site [active] 1045856008669 substrate binding site [chemical binding]; other site 1045856008670 protease 2; Provisional; Region: PRK10115 1045856008671 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1045856008672 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2979 1045856008673 tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178 1045856008674 putative metal binding site [ion binding]; other site 1045856008675 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 1045856008676 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1045856008677 ATP-grasp domain; Region: ATP-grasp; pfam02222 1045856008678 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 1045856008679 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 1045856008680 active site 1045856008681 intersubunit interface [polypeptide binding]; other site 1045856008682 catalytic residue [active] 1045856008683 phosphogluconate dehydratase; Validated; Region: PRK09054 1045856008684 6-phosphogluconate dehydratase; Region: edd; TIGR01196 1045856008685 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1045856008686 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1045856008687 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1045856008688 DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302 1045856008689 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1045856008690 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1045856008691 putative active site [active] 1045856008692 pyruvate kinase; Provisional; Region: PRK05826 1045856008693 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1045856008694 domain interfaces; other site 1045856008695 active site 1045856008696 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 1045856008697 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1045856008698 putative acyl-acceptor binding pocket; other site 1045856008699 putative peptidase; Provisional; Region: PRK11649 1045856008700 Opacity-associated protein A N-terminal motif; Region: OapA_N; pfam08525 1045856008701 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1045856008702 Peptidase family M23; Region: Peptidase_M23; pfam01551 1045856008703 high-affinity zinc transporter periplasmic component; Reviewed; Region: znuA; PRK09545 1045856008704 Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019 1045856008705 metal binding site [ion binding]; metal-binding site 1045856008706 high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544 1045856008707 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1045856008708 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1045856008709 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1045856008710 ABC-ATPase subunit interface; other site 1045856008711 dimer interface [polypeptide binding]; other site 1045856008712 putative PBP binding regions; other site 1045856008713 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1045856008714 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1045856008715 Walker A motif; other site 1045856008716 ATP binding site [chemical binding]; other site 1045856008717 Walker B motif; other site 1045856008718 arginine finger; other site 1045856008719 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1045856008720 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 1045856008721 RuvA N terminal domain; Region: RuvA_N; pfam01330 1045856008722 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 1045856008723 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 1045856008724 active site 1045856008725 putative DNA-binding cleft [nucleotide binding]; other site 1045856008726 dimer interface [polypeptide binding]; other site 1045856008727 hypothetical protein; Validated; Region: PRK00110 1045856008728 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 1045856008729 nudix motif; other site 1045856008730 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1045856008731 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1045856008732 dimer interface [polypeptide binding]; other site 1045856008733 anticodon binding site; other site 1045856008734 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1045856008735 homodimer interface [polypeptide binding]; other site 1045856008736 motif 1; other site 1045856008737 active site 1045856008738 motif 2; other site 1045856008739 GAD domain; Region: GAD; pfam02938 1045856008740 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1045856008741 active site 1045856008742 motif 3; other site 1045856008743 Isochorismatase family; Region: Isochorismatase; pfam00857 1045856008744 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1045856008745 catalytic triad [active] 1045856008746 conserved cis-peptide bond; other site 1045856008747 hypothetical protein; Provisional; Region: PRK10302 1045856008748 Uncharacterized relative of glutathione S-transferase, MAPEG superfamily [General function prediction only]; Region: COG3788 1045856008749 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 1045856008750 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1045856008751 S-adenosylmethionine binding site [chemical binding]; other site 1045856008752 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1045856008753 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1045856008754 S-adenosylmethionine binding site [chemical binding]; other site 1045856008755 copper homeostasis protein CutC; Provisional; Region: PRK11572 1045856008756 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_4; cd07268 1045856008757 putative metal binding site [ion binding]; other site 1045856008758 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 1045856008759 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 1045856008760 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1045856008761 active site 1045856008762 HIGH motif; other site 1045856008763 KMSK motif region; other site 1045856008764 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 1045856008765 tRNA binding surface [nucleotide binding]; other site 1045856008766 anticodon binding site; other site 1045856008767 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 1045856008768 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 1045856008769 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1045856008770 Flagellar protein FlhE; Region: FlhE; pfam06366 1045856008771 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 1045856008772 FHIPEP family; Region: FHIPEP; pfam00771 1045856008773 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 1045856008774 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 1045856008775 chemotaxis regulator CheZ; Provisional; Region: PRK11166 1045856008776 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 1045856008777 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1045856008778 active site 1045856008779 phosphorylation site [posttranslational modification] 1045856008780 intermolecular recognition site; other site 1045856008781 dimerization interface [polypeptide binding]; other site 1045856008782 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 1045856008783 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1045856008784 active site 1045856008785 phosphorylation site [posttranslational modification] 1045856008786 intermolecular recognition site; other site 1045856008787 dimerization interface [polypeptide binding]; other site 1045856008788 CheB methylesterase; Region: CheB_methylest; pfam01339 1045856008789 chemotaxis methyltransferase CheR; Provisional; Region: PRK10611 1045856008790 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 1045856008791 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1045856008792 S-adenosylmethionine binding site [chemical binding]; other site 1045856008793 methyl-accepting protein IV; Provisional; Region: PRK09793 1045856008794 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 1045856008795 dimer interface [polypeptide binding]; other site 1045856008796 ligand binding site [chemical binding]; other site 1045856008797 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1045856008798 dimerization interface [polypeptide binding]; other site 1045856008799 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1045856008800 dimer interface [polypeptide binding]; other site 1045856008801 putative CheW interface [polypeptide binding]; other site 1045856008802 methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048 1045856008803 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 1045856008804 dimer interface [polypeptide binding]; other site 1045856008805 ligand binding site [chemical binding]; other site 1045856008806 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1045856008807 dimerization interface [polypeptide binding]; other site 1045856008808 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1045856008809 dimer interface [polypeptide binding]; other site 1045856008810 putative CheW interface [polypeptide binding]; other site 1045856008811 Spore Coat Protein U domain; Region: SCPU; pfam05229 1045856008812 PapC N-terminal domain; Region: PapC_N; pfam13954 1045856008813 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 1045856008814 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1045856008815 PapC C-terminal domain; Region: PapC_C; pfam13953 1045856008816 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 1045856008817 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1045856008818 Spore Coat Protein U domain; Region: SCPU; pfam05229 1045856008819 Spore Coat Protein U domain; Region: SCPU; cl02253 1045856008820 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1045856008821 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 1045856008822 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 1045856008823 putative CheA interaction surface; other site 1045856008824 chemotaxis protein CheA; Provisional; Region: PRK10547 1045856008825 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1045856008826 putative binding surface; other site 1045856008827 active site 1045856008828 CheY binding; Region: CheY-binding; pfam09078 1045856008829 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 1045856008830 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1045856008831 ATP binding site [chemical binding]; other site 1045856008832 Mg2+ binding site [ion binding]; other site 1045856008833 G-X-G motif; other site 1045856008834 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 1045856008835 flagellar motor protein MotB; Validated; Region: motB; PRK09041 1045856008836 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 1045856008837 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1045856008838 ligand binding site [chemical binding]; other site 1045856008839 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 1045856008840 flagellar motor protein MotA; Validated; Region: PRK09110 1045856008841 transcriptional activator FlhC; Provisional; Region: PRK12722 1045856008842 transcriptional activator FlhD; Provisional; Region: PRK02909 1045856008843 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1045856008844 Ligand Binding Site [chemical binding]; other site 1045856008845 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 1045856008846 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 1045856008847 active site 1045856008848 homotetramer interface [polypeptide binding]; other site 1045856008849 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187 1045856008850 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 1045856008851 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1045856008852 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1045856008853 TM-ABC transporter signature motif; other site 1045856008854 L-arabinose transporter ATP-binding protein; Provisional; Region: araG; PRK11288 1045856008855 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1045856008856 Walker A/P-loop; other site 1045856008857 ATP binding site [chemical binding]; other site 1045856008858 Q-loop/lid; other site 1045856008859 ABC transporter signature motif; other site 1045856008860 Walker B; other site 1045856008861 D-loop; other site 1045856008862 H-loop/switch region; other site 1045856008863 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1045856008864 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 1045856008865 Periplasmic L-arabinose-binding protein (ABP), a member of a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein superfamily; Region: PBP1_arabinose_binding; cd01540 1045856008866 ligand binding site [chemical binding]; other site 1045856008867 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 1045856008868 conserved cys residue [active] 1045856008869 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 1045856008870 Ferritin-like domain; Region: Ferritin; pfam00210 1045856008871 ferroxidase diiron center [ion binding]; other site 1045856008872 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK12489 1045856008873 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 1045856008874 Protein of unknown function (DUF2766); Region: DUF2766; pfam10964 1045856008875 hypothetical protein; Provisional; Region: PRK09273 1045856008876 Ribose 5-phosphate isomerase RpiB [Carbohydrate transport and metabolism]; Region: RpiB; COG0698 1045856008877 Ribose-5-phosphate isomerase; Region: DUF3666; pfam12408 1045856008878 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1045856008879 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1045856008880 substrate binding pocket [chemical binding]; other site 1045856008881 membrane-bound complex binding site; other site 1045856008882 hinge residues; other site 1045856008883 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1045856008884 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 1045856008885 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1045856008886 Zn2+ binding site [ion binding]; other site 1045856008887 Mg2+ binding site [ion binding]; other site 1045856008888 YecR-like lipoprotein; Region: YecR; pfam13992 1045856008889 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 1045856008890 Ferritin-like domain; Region: Ferritin; pfam00210 1045856008891 ferroxidase diiron center [ion binding]; other site 1045856008892 tyrosine transporter TyrP; Provisional; Region: PRK15132 1045856008893 aromatic amino acid transport protein; Region: araaP; TIGR00837 1045856008894 hypothetical protein; Provisional; Region: PRK10396 1045856008895 Uncharacterized protein family (UPF0149); Region: UPF0149; pfam03695 1045856008896 SEC-C motif; Region: SEC-C; pfam02810 1045856008897 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1045856008898 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 1045856008899 dimerization interface [polypeptide binding]; other site 1045856008900 ligand binding site [chemical binding]; other site 1045856008901 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1045856008902 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1045856008903 TM-ABC transporter signature motif; other site 1045856008904 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 1045856008905 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 1045856008906 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1045856008907 TM-ABC transporter signature motif; other site 1045856008908 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 1045856008909 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1045856008910 Walker A/P-loop; other site 1045856008911 ATP binding site [chemical binding]; other site 1045856008912 Q-loop/lid; other site 1045856008913 ABC transporter signature motif; other site 1045856008914 Walker B; other site 1045856008915 D-loop; other site 1045856008916 H-loop/switch region; other site 1045856008917 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1045856008918 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1045856008919 Walker A/P-loop; other site 1045856008920 ATP binding site [chemical binding]; other site 1045856008921 Q-loop/lid; other site 1045856008922 ABC transporter signature motif; other site 1045856008923 Walker B; other site 1045856008924 D-loop; other site 1045856008925 H-loop/switch region; other site 1045856008926 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1045856008927 DNA-binding site [nucleotide binding]; DNA binding site 1045856008928 RNA-binding motif; other site 1045856008929 DNA-binding transcriptional activator FucR; Provisional; Region: PRK10411 1045856008930 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 1045856008931 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1045856008932 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 1045856008933 phosphatidylglycerophosphate synthetase; Provisional; Region: PRK10832 1045856008934 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 1045856008935 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1045856008936 GIY-YIG motif/motif A; other site 1045856008937 active site 1045856008938 catalytic site [active] 1045856008939 putative DNA binding site [nucleotide binding]; other site 1045856008940 metal binding site [ion binding]; metal-binding site 1045856008941 UvrB/uvrC motif; Region: UVR; pfam02151 1045856008942 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1045856008943 Helix-hairpin-helix motif; Region: HHH; pfam00633 1045856008944 response regulator; Provisional; Region: PRK09483 1045856008945 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1045856008946 active site 1045856008947 phosphorylation site [posttranslational modification] 1045856008948 intermolecular recognition site; other site 1045856008949 dimerization interface [polypeptide binding]; other site 1045856008950 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1045856008951 DNA binding residues [nucleotide binding] 1045856008952 dimerization interface [polypeptide binding]; other site 1045856008953 hypothetical protein; Provisional; Region: PRK10613 1045856008954 DNA-binding transcriptional activator SdiA; Provisional; Region: PRK10188 1045856008955 Autoinducer binding domain; Region: Autoind_bind; pfam03472 1045856008956 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1045856008957 DNA binding residues [nucleotide binding] 1045856008958 dimerization interface [polypeptide binding]; other site 1045856008959 putative amino-acid ABC transporter ATP-binding protein YecC; Provisional; Region: PRK11264 1045856008960 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1045856008961 Walker A/P-loop; other site 1045856008962 ATP binding site [chemical binding]; other site 1045856008963 Q-loop/lid; other site 1045856008964 ABC transporter signature motif; other site 1045856008965 Walker B; other site 1045856008966 D-loop; other site 1045856008967 H-loop/switch region; other site 1045856008968 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1045856008969 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1045856008970 dimer interface [polypeptide binding]; other site 1045856008971 conserved gate region; other site 1045856008972 putative PBP binding loops; other site 1045856008973 ABC-ATPase subunit interface; other site 1045856008974 D-cysteine desulfhydrase; Validated; Region: PRK03910 1045856008975 Aminocyclopropane-1-carboxylate deaminase (ACCD): Pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of 1-aminocyclopropane-L-carboxylate (ACC), a precursor of the plant hormone ethylene, to alpha-ketobutyrate and ammonia; Region: ACCD; cd06449 1045856008976 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1045856008977 catalytic residue [active] 1045856008978 cystine transporter subunit; Provisional; Region: PRK11260 1045856008979 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1045856008980 substrate binding pocket [chemical binding]; other site 1045856008981 membrane-bound complex binding site; other site 1045856008982 hinge residues; other site 1045856008983 flagella biosynthesis protein FliZ; Provisional; Region: PRK11582 1045856008984 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 1045856008985 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1045856008986 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1045856008987 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1045856008988 DNA binding residues [nucleotide binding] 1045856008989 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 1045856008990 carbamoyl phosphate synthase-like protein; Provisional; Region: PRK12767 1045856008991 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1045856008992 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1045856008993 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1045856008994 inhibitor-cofactor binding pocket; inhibition site 1045856008995 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1045856008996 catalytic residue [active] 1045856008997 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1045856008998 S-adenosylmethionine binding site [chemical binding]; other site 1045856008999 Predicted methyltransferase regulatory domain; Region: MethyTransf_Reg; pfam10119 1045856009000 Predicted regulatory domain of a methyltransferase [General function prediction only]; Region: COG4797 1045856009001 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 1045856009002 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1045856009003 binding surface 1045856009004 TPR motif; other site 1045856009005 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 1045856009006 flagellin; Provisional; Region: PRK12802 1045856009007 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1045856009008 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1045856009009 flagellar capping protein; Reviewed; Region: fliD; PRK08032 1045856009010 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 1045856009011 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 1045856009012 flagellar protein FliS; Validated; Region: fliS; PRK05685 1045856009013 Flagellar protein FliT; Region: FliT; cl05125 1045856009014 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 1045856009015 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 1045856009016 active site 1045856009017 Na/Ca binding site [ion binding]; other site 1045856009018 catalytic site [active] 1045856009019 lipoprotein; Provisional; Region: PRK10397 1045856009020 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00253 1045856009021 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 1045856009022 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514 1045856009023 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 1045856009024 flagellar motor switch protein FliG; Region: fliG; TIGR00207 1045856009025 FliG C-terminal domain; Region: FliG_C; pfam01706 1045856009026 flagellar assembly protein H; Validated; Region: fliH; PRK05687 1045856009027 Essential protein Yae1, N terminal; Region: Yae1_N; pfam09811 1045856009028 Flagellar assembly protein FliH; Region: FliH; pfam02108 1045856009029 flagellum-specific ATP synthase; Validated; Region: fliI; PRK07960 1045856009030 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 1045856009031 Walker A motif/ATP binding site; other site 1045856009032 Walker B motif; other site 1045856009033 Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882 1045856009034 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689 1045856009035 flagellar hook-length control protein; Provisional; Region: PRK10118 1045856009036 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07021 1045856009037 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 1045856009038 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 1045856009039 flagellar motor switch protein FliN; Validated; Region: fliN; PRK07963 1045856009040 flagellar motor switch protein; Validated; Region: fliN; PRK05698 1045856009041 flagellar biosynthesis protein FliO; Provisional; Region: PRK11486 1045856009042 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 1045856009043 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 1045856009044 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 1045856009045 colanic acid capsular biosynthesis activation protein A; Provisional; Region: rcsA; PRK15411 1045856009046 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1045856009047 DNA binding residues [nucleotide binding] 1045856009048 dimerization interface [polypeptide binding]; other site 1045856009049 hypothetical protein; Provisional; Region: PRK10708 1045856009050 Protein of unknown function (DUF2525); Region: DUF2525; pfam10733 1045856009051 mannosyl-3-phosphoglycerate phosphatase; Reviewed; Region: PRK03669 1045856009052 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1045856009053 active site 1045856009054 motif I; other site 1045856009055 motif II; other site 1045856009056 putative diguanylate cyclase YedQ; Provisional; Region: PRK15426 1045856009057 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1045856009058 metal binding site [ion binding]; metal-binding site 1045856009059 active site 1045856009060 I-site; other site 1045856009061 Uncharacterized small protein (DUF2158); Region: DUF2158; cl02293 1045856009062 hypothetical protein; Provisional; Region: PRK10062 1045856009063 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 1045856009064 EamA-like transporter family; Region: EamA; pfam00892 1045856009065 EamA-like transporter family; Region: EamA; pfam00892 1045856009066 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 1045856009067 additional DNA contacts [nucleotide binding]; other site 1045856009068 mismatch recognition site; other site 1045856009069 active site 1045856009070 zinc binding site [ion binding]; other site 1045856009071 DNA intercalation site [nucleotide binding]; other site 1045856009072 DNA cytosine methylase; Provisional; Region: PRK10458 1045856009073 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1045856009074 cofactor binding site; other site 1045856009075 DNA binding site [nucleotide binding] 1045856009076 substrate interaction site [chemical binding]; other site 1045856009077 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 1045856009078 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1045856009079 Zn2+ binding site [ion binding]; other site 1045856009080 Mg2+ binding site [ion binding]; other site 1045856009081 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 1045856009082 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 1045856009083 putative active site [active] 1045856009084 sensory histidine kinase DcuS; Provisional; Region: PRK11086 1045856009085 PAS domain; Region: PAS; smart00091 1045856009086 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1045856009087 ATP binding site [chemical binding]; other site 1045856009088 Mg2+ binding site [ion binding]; other site 1045856009089 G-X-G motif; other site 1045856009090 DNA-binding transcriptional activator DcuR; Provisional; Region: PRK10430 1045856009091 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1045856009092 active site 1045856009093 phosphorylation site [posttranslational modification] 1045856009094 intermolecular recognition site; other site 1045856009095 dimerization interface [polypeptide binding]; other site 1045856009096 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 1045856009097 ApbE family; Region: ApbE; pfam02424 1045856009098 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 1045856009099 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1045856009100 putative active site [active] 1045856009101 putative FMN binding site [chemical binding]; other site 1045856009102 putative substrate binding site [chemical binding]; other site 1045856009103 putative catalytic residue [active] 1045856009104 FMN-binding domain; Region: FMN_bind; cl01081 1045856009105 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 1045856009106 L-aspartate oxidase; Provisional; Region: PRK06175 1045856009107 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1045856009108 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 1045856009109 transmembrane helices; other site 1045856009110 fumarate hydratase; Provisional; Region: PRK15389 1045856009111 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 1045856009112 Fumarase C-terminus; Region: Fumerase_C; pfam05683 1045856009113 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1045856009114 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1045856009115 LysR substrate binding domain; Region: LysR_substrate; pfam03466 1045856009116 dimerization interface [polypeptide binding]; other site 1045856009117 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1045856009118 Beta-lactamase; Region: Beta-lactamase; pfam00144 1045856009119 citrate-proton symporter; Provisional; Region: PRK15075 1045856009120 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1045856009121 putative substrate translocation pore; other site 1045856009122 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1045856009123 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1045856009124 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1045856009125 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1045856009126 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 1045856009127 putative dimerization interface [polypeptide binding]; other site 1045856009128 DgsA anti-repressor MtfA; Provisional; Region: PRK15410 1045856009129 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1045856009130 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1045856009131 putative substrate translocation pore; other site 1045856009132 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 1045856009133 IucA / IucC family; Region: IucA_IucC; pfam04183 1045856009134 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 1045856009135 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 1045856009136 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 1045856009137 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 1045856009138 IucA / IucC family; Region: IucA_IucC; pfam04183 1045856009139 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 1045856009140 Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486 1045856009141 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1045856009142 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1045856009143 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1045856009144 N-terminal plug; other site 1045856009145 ligand-binding site [chemical binding]; other site 1045856009146 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1045856009147 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 1045856009148 C-terminal domain interface [polypeptide binding]; other site 1045856009149 GSH binding site (G-site) [chemical binding]; other site 1045856009150 dimer interface [polypeptide binding]; other site 1045856009151 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 1045856009152 N-terminal domain interface [polypeptide binding]; other site 1045856009153 dimer interface [polypeptide binding]; other site 1045856009154 substrate binding pocket (H-site) [chemical binding]; other site 1045856009155 transcriptional regulator Cbl; Reviewed; Region: cbl; PRK12679 1045856009156 The C-terminal substrate binding domain of LysR-type transcriptional regulator Cbl, which is required for expression of sulfate starvation-inducible (ssi) genes, contains the type 2 periplasmic binding fold; Region: PBP2_Cbl; cd08444 1045856009157 putative substrate binding site [chemical binding]; other site 1045856009158 dimerization interface [polypeptide binding]; other site 1045856009159 nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233 1045856009160 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1045856009161 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 1045856009162 putative dimerization interface [polypeptide binding]; other site 1045856009163 L,D-transpeptidase; Provisional; Region: PRK10190 1045856009164 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1045856009165 shikimate transporter; Provisional; Region: PRK09952 1045856009166 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1045856009167 putative substrate translocation pore; other site 1045856009168 AMP nucleosidase; Provisional; Region: PRK08292 1045856009169 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 1045856009170 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 1045856009171 MATE family multidrug exporter; Provisional; Region: PRK10189 1045856009172 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 1045856009173 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1045856009174 putative active site pocket [active] 1045856009175 dimerization interface [polypeptide binding]; other site 1045856009176 putative catalytic residue [active] 1045856009177 hypothetical protein; Provisional; Region: PRK05423 1045856009178 Predicted membrane protein [Function unknown]; Region: COG1289 1045856009179 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1045856009180 DNA gyrase inhibitor; Provisional; Region: PRK10016 1045856009181 D-alanyl-D-alanine carboxypeptidase; Provisional; Region: dacD; PRK11397 1045856009182 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1045856009183 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 1045856009184 exonuclease I; Provisional; Region: sbcB; PRK11779 1045856009185 N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138 1045856009186 active site 1045856009187 catalytic site [active] 1045856009188 substrate binding site [chemical binding]; other site 1045856009189 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 1045856009190 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1045856009191 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1045856009192 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 1045856009193 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1045856009194 dimerization interface [polypeptide binding]; other site 1045856009195 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1045856009196 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 1045856009197 putative NAD(P) binding site [chemical binding]; other site 1045856009198 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 1045856009199 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 1045856009200 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 1045856009201 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 1045856009202 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 1045856009203 NAD binding site [chemical binding]; other site 1045856009204 dimerization interface [polypeptide binding]; other site 1045856009205 product binding site; other site 1045856009206 substrate binding site [chemical binding]; other site 1045856009207 zinc binding site [ion binding]; other site 1045856009208 catalytic residues [active] 1045856009209 histidinol-phosphate aminotransferase; Provisional; Region: PRK01688 1045856009210 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1045856009211 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1045856009212 homodimer interface [polypeptide binding]; other site 1045856009213 catalytic residue [active] 1045856009214 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446 1045856009215 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1045856009216 active site 1045856009217 motif I; other site 1045856009218 motif II; other site 1045856009219 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 1045856009220 putative active site pocket [active] 1045856009221 4-fold oligomerization interface [polypeptide binding]; other site 1045856009222 metal binding residues [ion binding]; metal-binding site 1045856009223 3-fold/trimer interface [polypeptide binding]; other site 1045856009224 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13170 1045856009225 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 1045856009226 putative active site [active] 1045856009227 oxyanion strand; other site 1045856009228 catalytic triad [active] 1045856009229 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 1045856009230 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 1045856009231 catalytic residues [active] 1045856009232 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 1045856009233 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1045856009234 substrate binding site [chemical binding]; other site 1045856009235 glutamase interaction surface [polypeptide binding]; other site 1045856009236 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 1045856009237 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 1045856009238 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 1045856009239 metal binding site [ion binding]; metal-binding site 1045856009240 chain length determinant protein WzzB; Provisional; Region: PRK15471 1045856009241 Chain length determinant protein; Region: Wzz; pfam02706 1045856009242 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1045856009243 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 1045856009244 putative NAD(P) binding site [chemical binding]; other site 1045856009245 active site 1045856009246 putative substrate binding site [chemical binding]; other site 1045856009247 UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057 1045856009248 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1045856009249 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1045856009250 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1045856009251 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1045856009252 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 1045856009253 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 1045856009254 beta-1,6-galactofuranosyltransferase; Provisional; Region: PRK09814 1045856009255 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 1045856009256 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1045856009257 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 1045856009258 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1045856009259 Probable Catalytic site; other site 1045856009260 metal-binding site 1045856009261 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 1045856009262 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 1045856009263 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 1045856009264 substrate binding site; other site 1045856009265 tetramer interface; other site 1045856009266 dTDP-4-dehydrorhamnose reductase; Provisional; Region: PRK09987 1045856009267 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 1045856009268 NADP binding site [chemical binding]; other site 1045856009269 active site 1045856009270 putative substrate binding site [chemical binding]; other site 1045856009271 dTDP-glucose 4,6 dehydratase; Provisional; Region: PRK10084 1045856009272 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 1045856009273 NAD binding site [chemical binding]; other site 1045856009274 substrate binding site [chemical binding]; other site 1045856009275 homodimer interface [polypeptide binding]; other site 1045856009276 active site 1045856009277 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1045856009278 active site 1045856009279 tetramer interface; other site 1045856009280 putative colanic acid biosynthesis protein; Provisional; Region: wcaM; PRK10123 1045856009281 colanic acid biosynthesis glycosyltransferase WcaL; Provisional; Region: PRK15427 1045856009282 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 1045856009283 putative ADP-binding pocket [chemical binding]; other site 1045856009284 colanic acid biosynthesis pyruvyl transferase WcaK; Region: wcaK; TIGR04006 1045856009285 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327 1045856009286 colanic acid exporter; Provisional; Region: PRK10459 1045856009287 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 1045856009288 putative UDP-glucose lipid carrier transferase; Provisional; Region: PRK10124 1045856009289 Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148 1045856009290 phosphomannomutase CpsG; Provisional; Region: PRK15414 1045856009291 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 1045856009292 active site 1045856009293 substrate binding site [chemical binding]; other site 1045856009294 metal binding site [ion binding]; metal-binding site 1045856009295 mannose-1-phosphate guanyltransferase; Provisional; Region: cpsB; PRK15460 1045856009296 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 1045856009297 Substrate binding site; other site 1045856009298 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 1045856009299 colanic acid biosynthesis glycosyl transferase WcaI; Region: wcaI; TIGR04007 1045856009300 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 1045856009301 GDP-mannose glycosyl hydrolase (AKA GDP-mannose mannosyl hydrolase (GDPMH)) is a member of the Nudix hydrolase superfamily. This class of enzymes is unique from other members of the superfamily in two aspects. First, it contains a modified Nudix...; Region: GDPMH; cd03430 1045856009302 active site 1045856009303 GDP-Mannose binding site [chemical binding]; other site 1045856009304 dimer interface [polypeptide binding]; other site 1045856009305 modified nudix motif 1045856009306 metal binding site [ion binding]; metal-binding site 1045856009307 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 1045856009308 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 1045856009309 NADP binding site [chemical binding]; other site 1045856009310 active site 1045856009311 putative substrate binding site [chemical binding]; other site 1045856009312 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 1045856009313 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 1045856009314 NADP-binding site; other site 1045856009315 homotetramer interface [polypeptide binding]; other site 1045856009316 substrate binding site [chemical binding]; other site 1045856009317 homodimer interface [polypeptide binding]; other site 1045856009318 active site 1045856009319 colanic acid biosynthesis acetyltransferase WcaF; Region: WcaF; TIGR04008 1045856009320 wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825 1045856009321 putative trimer interface [polypeptide binding]; other site 1045856009322 putative active site [active] 1045856009323 putative substrate binding site [chemical binding]; other site 1045856009324 putative CoA binding site [chemical binding]; other site 1045856009325 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1045856009326 putative glycosyl transferase; Provisional; Region: PRK10063 1045856009327 active site 1045856009328 putative colanic acid polymerase WcaD; Region: WcaD; TIGR04010 1045856009329 colanic acid biosynthesis glycosyl transferase WcaC; Region: WcaC; TIGR04015 1045856009330 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1045856009331 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1045856009332 putative acyl transferase; Provisional; Region: PRK10191 1045856009333 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1045856009334 trimer interface [polypeptide binding]; other site 1045856009335 active site 1045856009336 substrate binding site [chemical binding]; other site 1045856009337 CoA binding site [chemical binding]; other site 1045856009338 putative glycosyl transferase; Provisional; Region: PRK10018 1045856009339 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 1045856009340 active site 1045856009341 tyrosine kinase; Provisional; Region: PRK11519 1045856009342 Chain length determinant protein; Region: Wzz; pfam02706 1045856009343 Chain length determinant protein; Region: Wzz; cl15801 1045856009344 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 1045856009345 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1045856009346 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1045856009347 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 1045856009348 active site 1045856009349 polysaccharide export protein Wza; Provisional; Region: PRK15078 1045856009350 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 1045856009351 SLBB domain; Region: SLBB; pfam10531 1045856009352 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 1045856009353 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1045856009354 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1045856009355 Transporter associated domain; Region: CorC_HlyC; smart01091 1045856009356 putative assembly protein; Provisional; Region: PRK10833 1045856009357 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 1045856009358 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 1045856009359 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1045856009360 trimer interface [polypeptide binding]; other site 1045856009361 active site 1045856009362 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 1045856009363 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 1045856009364 ATP-binding site [chemical binding]; other site 1045856009365 Sugar specificity; other site 1045856009366 Pyrimidine base specificity; other site 1045856009367 Predicted integral membrane sensor domain [Signal transduction mechanisms]; Region: COG3447 1045856009368 putative diguanylate cyclase; Provisional; Region: PRK09776 1045856009369 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1045856009370 putative active site [active] 1045856009371 heme pocket [chemical binding]; other site 1045856009372 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1045856009373 putative active site [active] 1045856009374 heme pocket [chemical binding]; other site 1045856009375 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1045856009376 putative active site [active] 1045856009377 heme pocket [chemical binding]; other site 1045856009378 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1045856009379 metal binding site [ion binding]; metal-binding site 1045856009380 active site 1045856009381 I-site; other site 1045856009382 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290 1045856009383 3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308 1045856009384 AlkA N-terminal domain; Region: AlkA_N; pfam06029 1045856009385 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1045856009386 minor groove reading motif; other site 1045856009387 helix-hairpin-helix signature motif; other site 1045856009388 substrate binding pocket [chemical binding]; other site 1045856009389 active site 1045856009390 putative chaperone; Provisional; Region: PRK11678 1045856009391 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 1045856009392 nucleotide binding site [chemical binding]; other site 1045856009393 putative NEF/HSP70 interaction site [polypeptide binding]; other site 1045856009394 SBD interface [polypeptide binding]; other site 1045856009395 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1045856009396 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 1045856009397 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1045856009398 DNA binding site [nucleotide binding] 1045856009399 putative fimbrial protein TcfA; Provisional; Region: PRK15308 1045856009400 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1045856009401 putative fimbrial protein TcfA; Provisional; Region: PRK15308 1045856009402 multidrug efflux system subunit MdtA; Provisional; Region: PRK11556 1045856009403 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1045856009404 HlyD family secretion protein; Region: HlyD_3; pfam13437 1045856009405 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 1045856009406 Protein export membrane protein; Region: SecD_SecF; cl14618 1045856009407 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 1045856009408 putative transporter; Provisional; Region: PRK10504 1045856009409 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1045856009410 putative substrate translocation pore; other site 1045856009411 signal transduction histidine-protein kinase BaeS; Provisional; Region: PRK10549 1045856009412 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1045856009413 dimerization interface [polypeptide binding]; other site 1045856009414 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1045856009415 dimer interface [polypeptide binding]; other site 1045856009416 phosphorylation site [posttranslational modification] 1045856009417 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1045856009418 ATP binding site [chemical binding]; other site 1045856009419 Mg2+ binding site [ion binding]; other site 1045856009420 G-X-G motif; other site 1045856009421 DNA-binding transcriptional regulator BaeR; Provisional; Region: PRK10710 1045856009422 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1045856009423 active site 1045856009424 phosphorylation site [posttranslational modification] 1045856009425 intermolecular recognition site; other site 1045856009426 dimerization interface [polypeptide binding]; other site 1045856009427 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1045856009428 DNA binding site [nucleotide binding] 1045856009429 Uncharacterized conserved protein [Function unknown]; Region: COG3422 1045856009430 Domain of unknown function (DUF1508); Region: DUF1508; pfam07411 1045856009431 putative protease; Provisional; Region: PRK15452 1045856009432 Peptidase family U32; Region: Peptidase_U32; pfam01136 1045856009433 lipid kinase; Reviewed; Region: PRK13054 1045856009434 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1045856009435 fructose-bisphosphate aldolase; Provisional; Region: PRK09250 1045856009436 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 1045856009437 putative active site; other site 1045856009438 catalytic residue [active] 1045856009439 nucleoside transporter; Region: 2A0110; TIGR00889 1045856009440 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1045856009441 putative substrate translocation pore; other site 1045856009442 ADP-ribosylglycohydrolase [Posttranslational modification, protein turnover, chaperones]; Region: DraG; COG1397 1045856009443 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 1045856009444 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1045856009445 substrate binding site [chemical binding]; other site 1045856009446 ATP binding site [chemical binding]; other site 1045856009447 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1045856009448 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1045856009449 DNA-binding site [nucleotide binding]; DNA binding site 1045856009450 UTRA domain; Region: UTRA; pfam07702 1045856009451 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1045856009452 dimer interface [polypeptide binding]; other site 1045856009453 substrate binding site [chemical binding]; other site 1045856009454 ATP binding site [chemical binding]; other site 1045856009455 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 1045856009456 substrate binding site [chemical binding]; other site 1045856009457 multimerization interface [polypeptide binding]; other site 1045856009458 ATP binding site [chemical binding]; other site 1045856009459 diaminobutyrate--2-oxoglutarate aminotransferase; Provisional; Region: PRK06931 1045856009460 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1045856009461 inhibitor-cofactor binding pocket; inhibition site 1045856009462 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1045856009463 catalytic residue [active] 1045856009464 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 1045856009465 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1045856009466 catalytic residue [active] 1045856009467 TlpA-like family, suppressor for copper sensitivity D protein (ScsD) and actinobacterial DsbE homolog subfamily; composed of ScsD, the DsbE homolog of Mycobacterium tuberculosis (MtbDsbE) and similar proteins, all containing a redox-active CXXC motif; Region: TlpA_like_ScsD_MtbDsbE; cd03011 1045856009468 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1045856009469 catalytic residues [active] 1045856009470 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1045856009471 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1045856009472 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1045856009473 dimerization interface [polypeptide binding]; other site 1045856009474 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 1045856009475 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1045856009476 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1045856009477 active site 1045856009478 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 1045856009479 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1045856009480 cryptic autophosphorylating protein tyrosine kinase Etk; Provisional; Region: PRK09841 1045856009481 Chain length determinant protein; Region: Wzz; pfam02706 1045856009482 Chain length determinant protein; Region: Wzz; cl15801 1045856009483 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 1045856009484 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1045856009485 Nucleotide binding site [chemical binding]; other site 1045856009486 DTAP/Switch II; other site 1045856009487 Switch I; other site 1045856009488 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1045856009489 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 1045856009490 active site 1045856009491 polysaccharide export protein Wza; Provisional; Region: PRK15078 1045856009492 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 1045856009493 SLBB domain; Region: SLBB; pfam10531 1045856009494 SLBB domain; Region: SLBB; pfam10531 1045856009495 Domain of unknown function (DUF3315); Region: DUF3315; cl02275 1045856009496 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1045856009497 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1045856009498 Coenzyme A binding pocket [chemical binding]; other site 1045856009499 antiporter inner membrane protein; Provisional; Region: PRK11670 1045856009500 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 1045856009501 Walker A motif; other site 1045856009502 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 1045856009503 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1045856009504 active site 1045856009505 HIGH motif; other site 1045856009506 KMSKS motif; other site 1045856009507 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1045856009508 tRNA binding surface [nucleotide binding]; other site 1045856009509 anticodon binding site; other site 1045856009510 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 1045856009511 dimer interface [polypeptide binding]; other site 1045856009512 putative tRNA-binding site [nucleotide binding]; other site 1045856009513 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807 1045856009514 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 1045856009515 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 1045856009516 putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697 1045856009517 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1045856009518 active site 1045856009519 phosphorylation site [posttranslational modification] 1045856009520 intermolecular recognition site; other site 1045856009521 dimerization interface [polypeptide binding]; other site 1045856009522 LytTr DNA-binding domain; Region: LytTR; pfam04397 1045856009523 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 1045856009524 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 1045856009525 GAF domain; Region: GAF; pfam01590 1045856009526 Histidine kinase; Region: His_kinase; pfam06580 1045856009527 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1045856009528 ATP binding site [chemical binding]; other site 1045856009529 Mg2+ binding site [ion binding]; other site 1045856009530 G-X-G motif; other site 1045856009531 transcriptional regulator MirA; Provisional; Region: PRK15043 1045856009532 Helix-Turn-Helix DNA binding domain of MlrA-like transcription regulators; Region: HTH_MlrA-like; cd04763 1045856009533 DNA binding residues [nucleotide binding] 1045856009534 hypothetical protein; Provisional; Region: PRK13681 1045856009535 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1045856009536 putative PBP binding loops; other site 1045856009537 ABC-ATPase subunit interface; other site 1045856009538 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 1045856009539 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 1045856009540 Walker A/P-loop; other site 1045856009541 ATP binding site [chemical binding]; other site 1045856009542 Q-loop/lid; other site 1045856009543 ABC transporter signature motif; other site 1045856009544 Walker B; other site 1045856009545 D-loop; other site 1045856009546 H-loop/switch region; other site 1045856009547 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 1045856009548 ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism]; Region: OpuBB; COG1174 1045856009549 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1045856009550 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 1045856009551 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 1045856009552 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 1045856009553 D-lactate dehydrogenase; Provisional; Region: PRK11183 1045856009554 FAD binding domain; Region: FAD_binding_4; pfam01565 1045856009555 D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330 1045856009556 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1045856009557 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1045856009558 Coenzyme A binding pocket [chemical binding]; other site 1045856009559 D-alanyl-D-alanine endopeptidase; Provisional; Region: pbpG; PRK11669 1045856009560 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 1045856009561 Protein of unknown function (DUF1282); Region: DUF1282; pfam06930 1045856009562 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1045856009563 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1045856009564 oxidoreductase; Provisional; Region: PRK12743 1045856009565 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1045856009566 NAD(P) binding site [chemical binding]; other site 1045856009567 active site 1045856009568 multidrug resistance outer membrane protein MdtQ; Provisional; Region: PRK11459 1045856009569 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 1045856009570 beta-galactosidase; Region: BGL; TIGR03356 1045856009571 PTS system beta-glucoside-specific transporter subunits IIABC; Provisional; Region: PRK09824 1045856009572 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1045856009573 active site turn [active] 1045856009574 phosphorylation site [posttranslational modification] 1045856009575 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1045856009576 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 1045856009577 HPr interaction site; other site 1045856009578 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1045856009579 active site 1045856009580 phosphorylation site [posttranslational modification] 1045856009581 transcriptional antiterminator BglG; Provisional; Region: PRK09772 1045856009582 CAT RNA binding domain; Region: CAT_RBD; smart01061 1045856009583 PRD domain; Region: PRD; pfam00874 1045856009584 PRD domain; Region: PRD; pfam00874 1045856009585 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 1045856009586 tRNA-dihydrouridine synthase C; Provisional; Region: PRK10550 1045856009587 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1045856009588 FMN binding site [chemical binding]; other site 1045856009589 active site 1045856009590 catalytic residues [active] 1045856009591 substrate binding site [chemical binding]; other site 1045856009592 hypothetical protein; Provisional; Region: PRK01821 1045856009593 hypothetical protein; Provisional; Region: PRK10711 1045856009594 cytidine deaminase; Provisional; Region: PRK09027 1045856009595 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 1045856009596 active site 1045856009597 catalytic motif [active] 1045856009598 Zn binding site [ion binding]; other site 1045856009599 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 1045856009600 active site 1045856009601 catalytic motif [active] 1045856009602 Zn binding site [ion binding]; other site 1045856009603 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1045856009604 putative active site [active] 1045856009605 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1045856009606 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1045856009607 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1045856009608 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1045856009609 TM-ABC transporter signature motif; other site 1045856009610 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1045856009611 galactose/methyl galaxtoside transporter ATP-binding protein; Provisional; Region: PRK10982 1045856009612 Walker A/P-loop; other site 1045856009613 ATP binding site [chemical binding]; other site 1045856009614 Q-loop/lid; other site 1045856009615 ABC transporter signature motif; other site 1045856009616 Walker B; other site 1045856009617 D-loop; other site 1045856009618 H-loop/switch region; other site 1045856009619 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1045856009620 methyl-galactoside ABC transporter galactose-binding periplasmic protein MglB; Provisional; Region: PRK15395 1045856009621 Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539 1045856009622 ligand binding site [chemical binding]; other site 1045856009623 calcium binding site [ion binding]; other site 1045856009624 DNA-binding transcriptional regulator GalS; Provisional; Region: PRK10401 1045856009625 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1045856009626 DNA binding site [nucleotide binding] 1045856009627 domain linker motif; other site 1045856009628 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 1045856009629 dimerization interface (closed form) [polypeptide binding]; other site 1045856009630 ligand binding site [chemical binding]; other site 1045856009631 Predicted membrane protein [Function unknown]; Region: COG2311 1045856009632 hypothetical protein; Provisional; Region: PRK10835 1045856009633 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 1045856009634 GTP cyclohydrolase I; Provisional; Region: PLN03044 1045856009635 active site 1045856009636 Protein of unknown function (DUF1228); Region: DUF1228; pfam06779 1045856009637 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 1045856009638 S-formylglutathione hydrolase; Region: PLN02442 1045856009639 putative outer membrane receptor; Provisional; Region: PRK13513 1045856009640 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1045856009641 N-terminal plug; other site 1045856009642 ligand-binding site [chemical binding]; other site 1045856009643 lysine transporter; Provisional; Region: PRK10836 1045856009644 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 1045856009645 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1045856009646 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 1045856009647 putative dimerization interface [polypeptide binding]; other site 1045856009648 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 1045856009649 endonuclease IV; Provisional; Region: PRK01060 1045856009650 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 1045856009651 DNA interaction; other site 1045856009652 Metal-binding active site; metal-binding site 1045856009653 AP (apurinic/apyrimidinic) site pocket; other site 1045856009654 PTS system fructose-specific transporter subunits IIBC; Provisional; Region: PRK10712 1045856009655 N-terminal domain of the phosphotransferase system fructose-specific component IIB [Carbohydrate transport and metabolism]; Region: COG3925 1045856009656 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1045856009657 active site 1045856009658 P-loop; other site 1045856009659 phosphorylation site [posttranslational modification] 1045856009660 PTS system, fructose subfamily, IIC component; Region: PTS_IIC_fructo; TIGR01427 1045856009661 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 1045856009662 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1045856009663 putative substrate binding site [chemical binding]; other site 1045856009664 putative ATP binding site [chemical binding]; other site 1045856009665 bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional; Region: PRK11109 1045856009666 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1045856009667 active site 1045856009668 phosphorylation site [posttranslational modification] 1045856009669 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1045856009670 dimerization domain swap beta strand [polypeptide binding]; other site 1045856009671 regulatory protein interface [polypeptide binding]; other site 1045856009672 active site 1045856009673 regulatory phosphorylation site [posttranslational modification]; other site 1045856009674 sugar efflux transporter B; Provisional; Region: PRK15011 1045856009675 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1045856009676 putative substrate translocation pore; other site 1045856009677 Flagellin N-methylase; Region: FliB; cl00497 1045856009678 elongation factor P; Provisional; Region: PRK04542 1045856009679 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1045856009680 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1045856009681 RNA binding site [nucleotide binding]; other site 1045856009682 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1045856009683 RNA binding site [nucleotide binding]; other site 1045856009684 mannonate dehydratase; Provisional; Region: PRK03906 1045856009685 mannonate dehydratase; Region: uxuA; TIGR00695 1045856009686 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 1045856009687 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1045856009688 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1045856009689 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1045856009690 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 1045856009691 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 1045856009692 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 1045856009693 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1045856009694 active site 1045856009695 outer membrane lipoprotein; Provisional; Region: spr; PRK10838 1045856009696 NlpC/P60 family; Region: NLPC_P60; pfam00877 1045856009697 phage resistance protein; Provisional; Region: PRK10551 1045856009698 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 1045856009699 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1045856009700 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1045856009701 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 1045856009702 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 1045856009703 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1045856009704 dimer interface [polypeptide binding]; other site 1045856009705 conserved gate region; other site 1045856009706 putative PBP binding loops; other site 1045856009707 ABC-ATPase subunit interface; other site 1045856009708 microcin C ABC transporter permease; Provisional; Region: PRK15021 1045856009709 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1045856009710 dimer interface [polypeptide binding]; other site 1045856009711 conserved gate region; other site 1045856009712 ABC-ATPase subunit interface; other site 1045856009713 microcin C ABC transporter ATP-binding protein YejF; Provisional; Region: PRK15134 1045856009714 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1045856009715 Walker A/P-loop; other site 1045856009716 ATP binding site [chemical binding]; other site 1045856009717 Q-loop/lid; other site 1045856009718 ABC transporter signature motif; other site 1045856009719 Walker B; other site 1045856009720 D-loop; other site 1045856009721 H-loop/switch region; other site 1045856009722 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1045856009723 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1045856009724 Walker A/P-loop; other site 1045856009725 ATP binding site [chemical binding]; other site 1045856009726 Q-loop/lid; other site 1045856009727 ABC transporter signature motif; other site 1045856009728 Walker B; other site 1045856009729 D-loop; other site 1045856009730 H-loop/switch region; other site 1045856009731 hypothetical protein; Provisional; Region: PRK11835 1045856009732 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1045856009733 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 1045856009734 putative substrate translocation pore; other site 1045856009735 16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839 1045856009736 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1045856009737 RNA binding surface [nucleotide binding]; other site 1045856009738 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 1045856009739 active site 1045856009740 uracil binding [chemical binding]; other site 1045856009741 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1045856009742 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1045856009743 ATP binding site [chemical binding]; other site 1045856009744 putative Mg++ binding site [ion binding]; other site 1045856009745 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1045856009746 nucleotide binding region [chemical binding]; other site 1045856009747 ATP-binding site [chemical binding]; other site 1045856009748 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 1045856009749 5S rRNA interface [nucleotide binding]; other site 1045856009750 CTC domain interface [polypeptide binding]; other site 1045856009751 L16 interface [polypeptide binding]; other site 1045856009752 Nucleoid-associated protein [General function prediction only]; Region: COG3081 1045856009753 nucleoid-associated protein NdpA; Validated; Region: PRK00378 1045856009754 hypothetical protein; Provisional; Region: PRK13689 1045856009755 Predicted hydrolase of alkaline phosphatase superfamily [General function prediction only]; Region: COG3083 1045856009756 Domain of unknown function (DUF3413); Region: DUF3413; pfam11893 1045856009757 Sulfatase; Region: Sulfatase; cl17466 1045856009758 DinI-like family; Region: DinI; pfam06183 1045856009759 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1045856009760 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1045856009761 putative substrate translocation pore; other site 1045856009762 Protein of unknown function (DUF2534); Region: DUF2534; pfam10749 1045856009763 Protease Inhibitor Ecotin; homodimeric protease inhibitor; Region: Ecotin; cd00242 1045856009764 secondary substrate binding site; other site 1045856009765 primary substrate binding site; other site 1045856009766 inhibition loop; other site 1045856009767 dimerization interface [polypeptide binding]; other site 1045856009768 malate:quinone oxidoreductase; Validated; Region: PRK05257 1045856009769 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 1045856009770 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1045856009771 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1045856009772 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1045856009773 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 1045856009774 MgtE intracellular N domain; Region: MgtE_N; smart00924 1045856009775 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1045856009776 Divalent cation transporter; Region: MgtE; cl00786 1045856009777 multidrug transporter membrane component/ATP-binding component; Provisional; Region: PRK10522 1045856009778 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1045856009779 Walker A/P-loop; other site 1045856009780 ATP binding site [chemical binding]; other site 1045856009781 Q-loop/lid; other site 1045856009782 ABC transporter signature motif; other site 1045856009783 Walker B; other site 1045856009784 D-loop; other site 1045856009785 H-loop/switch region; other site 1045856009786 alpha-ketoglutarate-dependent dioxygenase AlkB; Provisional; Region: PRK15401 1045856009787 bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435 1045856009788 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 1045856009789 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1045856009790 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1045856009791 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 1045856009792 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1045856009793 DNA binding site [nucleotide binding] 1045856009794 active site 1045856009795 thiamine biosynthesis lipoprotein ApbE; Provisional; Region: PRK10461 1045856009796 ApbE family; Region: ApbE; pfam02424 1045856009797 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1045856009798 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 1045856009799 trimer interface [polypeptide binding]; other site 1045856009800 eyelet of channel; other site 1045856009801 phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional; Region: PRK10618 1045856009802 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1045856009803 ATP binding site [chemical binding]; other site 1045856009804 Mg2+ binding site [ion binding]; other site 1045856009805 G-X-G motif; other site 1045856009806 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1045856009807 putative binding surface; other site 1045856009808 active site 1045856009809 transcriptional regulator RcsB; Provisional; Region: PRK10840 1045856009810 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1045856009811 active site 1045856009812 phosphorylation site [posttranslational modification] 1045856009813 intermolecular recognition site; other site 1045856009814 dimerization interface [polypeptide binding]; other site 1045856009815 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1045856009816 DNA binding residues [nucleotide binding] 1045856009817 dimerization interface [polypeptide binding]; other site 1045856009818 hybrid sensory kinase in two-component regulatory system with RcsB and YojN; Provisional; Region: PRK10841 1045856009819 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1045856009820 dimer interface [polypeptide binding]; other site 1045856009821 phosphorylation site [posttranslational modification] 1045856009822 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1045856009823 ATP binding site [chemical binding]; other site 1045856009824 Mg2+ binding site [ion binding]; other site 1045856009825 G-X-G motif; other site 1045856009826 RcsC Alpha-Beta-Loop (ABL); Region: RcsC; pfam09456 1045856009827 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1045856009828 active site 1045856009829 phosphorylation site [posttranslational modification] 1045856009830 intermolecular recognition site; other site 1045856009831 dimerization interface [polypeptide binding]; other site 1045856009832 DNA gyrase subunit A; Validated; Region: PRK05560 1045856009833 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1045856009834 CAP-like domain; other site 1045856009835 active site 1045856009836 primary dimer interface [polypeptide binding]; other site 1045856009837 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1045856009838 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1045856009839 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1045856009840 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1045856009841 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1045856009842 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1045856009843 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 1045856009844 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1045856009845 S-adenosylmethionine binding site [chemical binding]; other site 1045856009846 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09103 1045856009847 ATP cone domain; Region: ATP-cone; pfam03477 1045856009848 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1045856009849 active site 1045856009850 dimer interface [polypeptide binding]; other site 1045856009851 catalytic residues [active] 1045856009852 effector binding site; other site 1045856009853 R2 peptide binding site; other site 1045856009854 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1045856009855 dimer interface [polypeptide binding]; other site 1045856009856 putative radical transfer pathway; other site 1045856009857 diiron center [ion binding]; other site 1045856009858 tyrosyl radical; other site 1045856009859 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1045856009860 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1045856009861 catalytic loop [active] 1045856009862 iron binding site [ion binding]; other site 1045856009863 glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143 1045856009864 Glycerophosphodiester phosphodiesterase domain of Escherichia coli (GlpQ) and similar proteins; Region: GDPD_EcGlpQ_like; cd08600 1045856009865 active site 1045856009866 catalytic site [active] 1045856009867 metal binding site [ion binding]; metal-binding site 1045856009868 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 1045856009869 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1045856009870 putative substrate translocation pore; other site 1045856009871 sn-glycerol-3-phosphate dehydrogenase subunit A; Provisional; Region: glpA; PRK11101 1045856009872 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1045856009873 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1045856009874 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; COG3075 1045856009875 anaerobic glycerol-3-phosphate dehydrogenase subunit B; Validated; Region: PRK05329 1045856009876 glycerol-3-phosphate dehydrogenase, anaerobic, C subunit; Region: glycerol3P_GlpC; TIGR03379 1045856009877 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1045856009878 Cysteine-rich domain; Region: CCG; pfam02754 1045856009879 Cysteine-rich domain; Region: CCG; pfam02754 1045856009880 hypothetical protein; Provisional; Region: PRK03673 1045856009881 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 1045856009882 putative MPT binding site; other site 1045856009883 Competence-damaged protein; Region: CinA; cl00666 1045856009884 YfaZ precursor; Region: YfaZ; pfam07437 1045856009885 outer membrane protein; Region: OMP_w_GlyGly; TIGR04219 1045856009886 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 1045856009887 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1045856009888 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1045856009889 dimer interface [polypeptide binding]; other site 1045856009890 phosphorylation site [posttranslational modification] 1045856009891 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1045856009892 ATP binding site [chemical binding]; other site 1045856009893 Mg2+ binding site [ion binding]; other site 1045856009894 G-X-G motif; other site 1045856009895 transcriptional regulatory protein TctD; Provisional; Region: PRK15479 1045856009896 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1045856009897 active site 1045856009898 phosphorylation site [posttranslational modification] 1045856009899 intermolecular recognition site; other site 1045856009900 dimerization interface [polypeptide binding]; other site 1045856009901 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1045856009902 DNA binding site [nucleotide binding] 1045856009903 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 1045856009904 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 1045856009905 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 1045856009906 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 1045856009907 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK09029 1045856009908 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 1045856009909 acyl-activating enzyme (AAE) consensus motif; other site 1045856009910 putative AMP binding site [chemical binding]; other site 1045856009911 putative active site [active] 1045856009912 putative CoA binding site [chemical binding]; other site 1045856009913 O-succinylbenzoate synthase; Provisional; Region: PRK05105 1045856009914 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 1045856009915 active site 1045856009916 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1045856009917 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1045856009918 substrate binding site [chemical binding]; other site 1045856009919 oxyanion hole (OAH) forming residues; other site 1045856009920 trimer interface [polypeptide binding]; other site 1045856009921 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Provisional; Region: PRK11126 1045856009922 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 1045856009923 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 1045856009924 dimer interface [polypeptide binding]; other site 1045856009925 tetramer interface [polypeptide binding]; other site 1045856009926 PYR/PP interface [polypeptide binding]; other site 1045856009927 TPP binding site [chemical binding]; other site 1045856009928 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 1045856009929 TPP-binding site; other site 1045856009930 menaquinone-specific isochorismate synthase; Provisional; Region: PRK15012 1045856009931 isochorismate synthases; Region: isochor_syn; TIGR00543 1045856009932 hypothetical protein; Provisional; Region: PRK10404 1045856009933 putative acyltransferase; Provisional; Region: PRK10314 1045856009934 Coenzyme A binding pocket [chemical binding]; other site 1045856009935 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1045856009936 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 1045856009937 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1045856009938 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1045856009939 active site 1045856009940 phosphorylation site [posttranslational modification] 1045856009941 intermolecular recognition site; other site 1045856009942 dimerization interface [polypeptide binding]; other site 1045856009943 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 1045856009944 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1045856009945 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 1045856009946 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1045856009947 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 1045856009948 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 1045856009949 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1045856009950 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 1045856009951 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 1045856009952 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 1045856009953 4Fe-4S binding domain; Region: Fer4; pfam00037 1045856009954 4Fe-4S binding domain; Region: Fer4; pfam00037 1045856009955 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 1045856009956 NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) [Energy production and conversion]; Region: NuoG; COG1034 1045856009957 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1045856009958 catalytic loop [active] 1045856009959 iron binding site [ion binding]; other site 1045856009960 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 1045856009961 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 1045856009962 [4Fe-4S] binding site [ion binding]; other site 1045856009963 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 1045856009964 NADH dehydrogenase I subunit F; Provisional; Region: PRK11278 1045856009965 SLBB domain; Region: SLBB; pfam10531 1045856009966 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 1045856009967 NADH dehydrogenase subunit E; Validated; Region: PRK07539 1045856009968 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 1045856009969 putative dimer interface [polypeptide binding]; other site 1045856009970 [2Fe-2S] cluster binding site [ion binding]; other site 1045856009971 bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742 1045856009972 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 1045856009973 NADH dehydrogenase subunit D; Validated; Region: PRK06075 1045856009974 NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases [Energy production and conversion]; Region: NuoB; COG0377 1045856009975 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 1045856009976 DNA-binding transcriptional repressor LrhA; Provisional; Region: PRK15092 1045856009977 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1045856009978 The C-terminal substrate domain of LysR-like regulator LrhA (LysR homologue A) and that of closely related homologs, contains the type 2 periplasmic binding fold; Region: PBP2_LrhA_like; cd08439 1045856009979 putative dimerization interface [polypeptide binding]; other site 1045856009980 aminotransferase AlaT; Validated; Region: PRK09265 1045856009981 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1045856009982 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1045856009983 homodimer interface [polypeptide binding]; other site 1045856009984 catalytic residue [active] 1045856009985 5'-nucleotidase; Provisional; Region: PRK03826 1045856009986 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 1045856009987 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1045856009988 TrkA-C domain; Region: TrkA_C; pfam02080 1045856009989 TrkA-C domain; Region: TrkA_C; pfam02080 1045856009990 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 1045856009991 putative phosphatase; Provisional; Region: PRK11587 1045856009992 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1045856009993 motif II; other site 1045856009994 hypothetical protein; Validated; Region: PRK05445 1045856009995 hypothetical protein; Provisional; Region: PRK01816 1045856009996 propionate/acetate kinase; Provisional; Region: PRK12379 1045856009997 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 1045856009998 phosphate acetyltransferase; Reviewed; Region: PRK05632 1045856009999 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1045856010000 DRTGG domain; Region: DRTGG; pfam07085 1045856010001 phosphate acetyltransferase; Region: pta; TIGR00651 1045856010002 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 1045856010003 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1045856010004 PYR/PP interface [polypeptide binding]; other site 1045856010005 dimer interface [polypeptide binding]; other site 1045856010006 TPP binding site [chemical binding]; other site 1045856010007 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1045856010008 transketolase; Reviewed; Region: PRK05899 1045856010009 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1045856010010 TPP-binding site [chemical binding]; other site 1045856010011 dimer interface [polypeptide binding]; other site 1045856010012 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK12996 1045856010013 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 1045856010014 active site 1045856010015 P-loop; other site 1045856010016 phosphorylation site [posttranslational modification] 1045856010017 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1045856010018 active site 1045856010019 phosphorylation site [posttranslational modification] 1045856010020 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1045856010021 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1045856010022 DNA binding site [nucleotide binding] 1045856010023 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 1045856010024 putative dimerization interface [polypeptide binding]; other site 1045856010025 putative ligand binding site [chemical binding]; other site 1045856010026 NUDIX hydrolase YfcD; Provisional; Region: PRK15393 1045856010027 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_38; cd04697 1045856010028 nudix motif; other site 1045856010029 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1045856010030 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 1045856010031 active site 1045856010032 metal binding site [ion binding]; metal-binding site 1045856010033 homotetramer interface [polypeptide binding]; other site 1045856010034 glutathione S-transferase; Provisional; Region: PRK15113 1045856010035 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1045856010036 C-terminal, alpha helical domain of an unknown subfamily 4 of Glutathione S-transferases; Region: GST_C_4; cd03195 1045856010037 N-terminal domain interface [polypeptide binding]; other site 1045856010038 putative dimer interface [polypeptide binding]; other site 1045856010039 putative substrate binding pocket (H-site) [chemical binding]; other site 1045856010040 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 1045856010041 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 1045856010042 C-terminal domain interface [polypeptide binding]; other site 1045856010043 GSH binding site (G-site) [chemical binding]; other site 1045856010044 dimer interface [polypeptide binding]; other site 1045856010045 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 1045856010046 N-terminal domain interface [polypeptide binding]; other site 1045856010047 putative dimer interface [polypeptide binding]; other site 1045856010048 active site 1045856010049 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 1045856010050 homooctamer interface [polypeptide binding]; other site 1045856010051 active site 1045856010052 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 1045856010053 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 1045856010054 putative NAD(P) binding site [chemical binding]; other site 1045856010055 putative active site [active] 1045856010056 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1045856010057 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1045856010058 Coenzyme A binding pocket [chemical binding]; other site 1045856010059 histidine/lysine/arginine/ornithine transporter subunit; Provisional; Region: PRK10619 1045856010060 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1045856010061 Walker A/P-loop; other site 1045856010062 ATP binding site [chemical binding]; other site 1045856010063 Q-loop/lid; other site 1045856010064 ABC transporter signature motif; other site 1045856010065 Walker B; other site 1045856010066 D-loop; other site 1045856010067 H-loop/switch region; other site 1045856010068 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1045856010069 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1045856010070 dimer interface [polypeptide binding]; other site 1045856010071 conserved gate region; other site 1045856010072 putative PBP binding loops; other site 1045856010073 ABC-ATPase subunit interface; other site 1045856010074 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1045856010075 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1045856010076 dimer interface [polypeptide binding]; other site 1045856010077 conserved gate region; other site 1045856010078 putative PBP binding loops; other site 1045856010079 ABC-ATPase subunit interface; other site 1045856010080 histidine ABC transporter substrate-binding protein HisJ; Provisional; Region: PRK15437 1045856010081 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1045856010082 substrate binding pocket [chemical binding]; other site 1045856010083 membrane-bound complex binding site; other site 1045856010084 hinge residues; other site 1045856010085 ABC transporter lysine/arginine/ornithine binding periplasmic protein; Provisional; Region: PRK15010 1045856010086 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1045856010087 substrate binding pocket [chemical binding]; other site 1045856010088 membrane-bound complex binding site; other site 1045856010089 hinge residues; other site 1045856010090 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 1045856010091 Flavoprotein; Region: Flavoprotein; pfam02441 1045856010092 amidophosphoribosyltransferase; Provisional; Region: PRK09246 1045856010093 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 1045856010094 active site 1045856010095 tetramer interface [polypeptide binding]; other site 1045856010096 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1045856010097 active site 1045856010098 colicin V production protein; Provisional; Region: PRK10845 1045856010099 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 1045856010100 cell division protein DedD; Provisional; Region: PRK11633 1045856010101 Sporulation related domain; Region: SPOR; pfam05036 1045856010102 bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846 1045856010103 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1045856010104 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1045856010105 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 1045856010106 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1045856010107 hypothetical protein; Provisional; Region: PRK10847 1045856010108 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1045856010109 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 1045856010110 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1045856010111 dimerization interface 3.5A [polypeptide binding]; other site 1045856010112 active site 1045856010113 putative semialdehyde dehydrogenase; Provisional; Region: PRK08040 1045856010114 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1045856010115 erythronate-4-phosphate dehydrogenase PdxB; Provisional; Region: PRK15438 1045856010116 D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158 1045856010117 ligand binding site [chemical binding]; other site 1045856010118 NAD binding site [chemical binding]; other site 1045856010119 catalytic site [active] 1045856010120 homodimer interface [polypeptide binding]; other site 1045856010121 flagella biosynthesis regulator; Provisional; Region: flk; PRK10715 1045856010122 putative transporter; Provisional; Region: PRK12382 1045856010123 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1045856010124 putative substrate translocation pore; other site 1045856010125 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 1045856010126 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1045856010127 dimer interface [polypeptide binding]; other site 1045856010128 active site 1045856010129 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 1045856010130 Uncharacterized conserved protein [Function unknown]; Region: COG4121 1045856010131 YfcL protein; Region: YfcL; pfam08891 1045856010132 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3101 1045856010133 hypothetical protein; Provisional; Region: PRK10621 1045856010134 Predicted permeases [General function prediction only]; Region: COG0730 1045856010135 Murein endopeptidase [Cell envelope biogenesis, outer membrane]; Region: MepA; COG3770 1045856010136 penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429 1045856010137 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 1045856010138 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 1045856010139 Tetramer interface [polypeptide binding]; other site 1045856010140 active site 1045856010141 FMN-binding site [chemical binding]; other site 1045856010142 HemK family putative methylases; Region: hemK_fam; TIGR00536 1045856010143 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1045856010144 S-adenosylmethionine binding site [chemical binding]; other site 1045856010145 hypothetical protein; Provisional; Region: PRK04946 1045856010146 Smr domain; Region: Smr; pfam01713 1045856010147 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1045856010148 catalytic core [active] 1045856010149 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 1045856010150 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1045856010151 substrate binding site [chemical binding]; other site 1045856010152 oxyanion hole (OAH) forming residues; other site 1045856010153 trimer interface [polypeptide binding]; other site 1045856010154 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1045856010155 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1045856010156 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1045856010157 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1045856010158 3-ketoacyl-CoA thiolase; Reviewed; Region: fadI; PRK08963 1045856010159 dimer interface [polypeptide binding]; other site 1045856010160 active site 1045856010161 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 1045856010162 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3691 1045856010163 long-chain fatty acid outer membrane transporter; Provisional; Region: PRK10716 1045856010164 ABC transporter outer membrane lipoprotein; Provisional; Region: PRK15091 1045856010165 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 1045856010166 cupin fold metalloprotein, WbuC family; Region: cupin_WbuC; TIGR04366 1045856010167 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 1045856010168 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1045856010169 putative acyl-acceptor binding pocket; other site 1045856010170 aminotransferase; Validated; Region: PRK08175 1045856010171 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1045856010172 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1045856010173 homodimer interface [polypeptide binding]; other site 1045856010174 catalytic residue [active] 1045856010175 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 1045856010176 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 1045856010177 GAF domain; Region: GAF; pfam01590 1045856010178 Histidine kinase; Region: His_kinase; pfam06580 1045856010179 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1045856010180 ATP binding site [chemical binding]; other site 1045856010181 Mg2+ binding site [ion binding]; other site 1045856010182 G-X-G motif; other site 1045856010183 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 1045856010184 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1045856010185 active site 1045856010186 phosphorylation site [posttranslational modification] 1045856010187 intermolecular recognition site; other site 1045856010188 dimerization interface [polypeptide binding]; other site 1045856010189 LytTr DNA-binding domain; Region: LytTR; pfam04397 1045856010190 glucokinase; Provisional; Region: glk; PRK00292 1045856010191 glucokinase, proteobacterial type; Region: glk; TIGR00749 1045856010192 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 1045856010193 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 1045856010194 Cl- selectivity filter; other site 1045856010195 Cl- binding residues [ion binding]; other site 1045856010196 pore gating glutamate residue; other site 1045856010197 dimer interface [polypeptide binding]; other site 1045856010198 indolepyruvate decarboxylase, Erwinia family; Region: indolpyr_decarb; TIGR03393 1045856010199 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 1045856010200 dimer interface [polypeptide binding]; other site 1045856010201 PYR/PP interface [polypeptide binding]; other site 1045856010202 TPP binding site [chemical binding]; other site 1045856010203 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1045856010204 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 1045856010205 TPP-binding site [chemical binding]; other site 1045856010206 dimer interface [polypeptide binding]; other site 1045856010207 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1045856010208 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1045856010209 active site 1045856010210 catalytic tetrad [active] 1045856010211 manganese transport protein MntH; Reviewed; Region: PRK00701 1045856010212 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1045856010213 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 1045856010214 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1045856010215 Nucleoside recognition; Region: Gate; pfam07670 1045856010216 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1045856010217 MASE1; Region: MASE1; pfam05231 1045856010218 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1045856010219 diguanylate cyclase; Region: GGDEF; smart00267 1045856010220 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1045856010221 Putative transcription regulator (DUF1323); Region: DUF1323; pfam07037 1045856010222 Putative transcription regulator (DUF1323); Region: DUF1323; pfam07037 1045856010223 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1045856010224 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1045856010225 active site 1045856010226 HIGH motif; other site 1045856010227 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1045856010228 active site 1045856010229 KMSKS motif; other site 1045856010230 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 1045856010231 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1045856010232 The C-terminal substrate binding domain of LysR-type transcriptional regulator XapR involved in xanthosine catabolism, contains the type 2 periplasmic binding fold; Region: PBP2_XapR; cd08449 1045856010233 putative dimerization interface [polypeptide binding]; other site 1045856010234 putative substrate binding pocket [chemical binding]; other site 1045856010235 nucleoside transporter; Region: 2A0110; TIGR00889 1045856010236 purine nucleoside phosphorylase; Provisional; Region: PRK08202 1045856010237 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1045856010238 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1045856010239 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 1045856010240 putative dimerization interface [polypeptide binding]; other site 1045856010241 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 1045856010242 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 1045856010243 Protein of unknown function (DUF3820); Region: DUF3820; pfam12843 1045856010244 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 1045856010245 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1045856010246 nucleotide binding pocket [chemical binding]; other site 1045856010247 K-X-D-G motif; other site 1045856010248 catalytic site [active] 1045856010249 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1045856010250 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 1045856010251 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1045856010252 Dimer interface [polypeptide binding]; other site 1045856010253 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cl12038 1045856010254 cell division protein ZipA; Provisional; Region: PRK03427 1045856010255 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cd00231 1045856010256 FtsZ protein binding site [polypeptide binding]; other site 1045856010257 putative sulfate transport protein CysZ; Validated; Region: PRK04949 1045856010258 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1045856010259 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1045856010260 dimer interface [polypeptide binding]; other site 1045856010261 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1045856010262 catalytic residue [active] 1045856010263 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1045856010264 dimerization domain swap beta strand [polypeptide binding]; other site 1045856010265 regulatory protein interface [polypeptide binding]; other site 1045856010266 active site 1045856010267 regulatory phosphorylation site [posttranslational modification]; other site 1045856010268 phosphoenolpyruvate-protein phosphotransferase; Provisional; Region: PRK11177 1045856010269 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1045856010270 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1045856010271 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1045856010272 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 1045856010273 HPr interaction site; other site 1045856010274 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1045856010275 active site 1045856010276 phosphorylation site [posttranslational modification] 1045856010277 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 1045856010278 dimer interface [polypeptide binding]; other site 1045856010279 pyridoxamine kinase; Validated; Region: PRK05756 1045856010280 pyridoxal binding site [chemical binding]; other site 1045856010281 ATP binding site [chemical binding]; other site 1045856010282 cysteine synthase B; Region: cysM; TIGR01138 1045856010283 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1045856010284 dimer interface [polypeptide binding]; other site 1045856010285 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1045856010286 catalytic residue [active] 1045856010287 sulfate/thiosulfate transporter subunit; Provisional; Region: PRK10851 1045856010288 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 1045856010289 Walker A/P-loop; other site 1045856010290 ATP binding site [chemical binding]; other site 1045856010291 Q-loop/lid; other site 1045856010292 ABC transporter signature motif; other site 1045856010293 Walker B; other site 1045856010294 D-loop; other site 1045856010295 H-loop/switch region; other site 1045856010296 TOBE-like domain; Region: TOBE_3; pfam12857 1045856010297 sulfate transport protein; Provisional; Region: cysT; CHL00187 1045856010298 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1045856010299 dimer interface [polypeptide binding]; other site 1045856010300 conserved gate region; other site 1045856010301 putative PBP binding loops; other site 1045856010302 ABC-ATPase subunit interface; other site 1045856010303 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1045856010304 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1045856010305 dimer interface [polypeptide binding]; other site 1045856010306 conserved gate region; other site 1045856010307 putative PBP binding loops; other site 1045856010308 ABC-ATPase subunit interface; other site 1045856010309 thiosulfate transporter subunit; Provisional; Region: PRK10852 1045856010310 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1045856010311 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 1045856010312 RpoE-regulated lipoprotein; Provisional; Region: PRK10718 1045856010313 Protein of unknown function (DUF1131); Region: DUF1131; pfam06572 1045856010314 Protein of unknown function (DUF2919); Region: DUF2919; pfam11143 1045856010315 putative acetyltransferase; Provisional; Region: PRK03624 1045856010316 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1045856010317 Coenzyme A binding pocket [chemical binding]; other site 1045856010318 N-acetylmuramoyl-l-alanine amidase I; Provisional; Region: PRK10319 1045856010319 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1045856010320 active site 1045856010321 metal binding site [ion binding]; metal-binding site 1045856010322 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 1045856010323 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 1045856010324 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 1045856010325 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1045856010326 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 1045856010327 putative NAD(P) binding site [chemical binding]; other site 1045856010328 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 1045856010329 transaldolase-like protein; Provisional; Region: PTZ00411 1045856010330 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 1045856010331 active site 1045856010332 dimer interface [polypeptide binding]; other site 1045856010333 catalytic residue [active] 1045856010334 transketolase; Reviewed; Region: PRK12753 1045856010335 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1045856010336 TPP-binding site [chemical binding]; other site 1045856010337 dimer interface [polypeptide binding]; other site 1045856010338 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1045856010339 PYR/PP interface [polypeptide binding]; other site 1045856010340 dimer interface [polypeptide binding]; other site 1045856010341 TPP binding site [chemical binding]; other site 1045856010342 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1045856010343 Protein of unknown function (DUF1176); Region: DUF1176; pfam06674 1045856010344 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 1045856010345 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1045856010346 dimer interface [polypeptide binding]; other site 1045856010347 ADP-ribose binding site [chemical binding]; other site 1045856010348 active site 1045856010349 nudix motif; other site 1045856010350 metal binding site [ion binding]; metal-binding site 1045856010351 putative oxidoreductase Fe-S binding subunit; Reviewed; Region: PRK12769 1045856010352 4Fe-4S binding domain; Region: Fer4; pfam00037 1045856010353 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1045856010354 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1045856010355 nitrate/nitrite sensor protein NarQ; Provisional; Region: PRK10935 1045856010356 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 1045856010357 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1045856010358 dimerization interface [polypeptide binding]; other site 1045856010359 Histidine kinase; Region: HisKA_3; pfam07730 1045856010360 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1045856010361 ATP binding site [chemical binding]; other site 1045856010362 Mg2+ binding site [ion binding]; other site 1045856010363 G-X-G motif; other site 1045856010364 aminoglycoside/multidrug efflux system; Provisional; Region: PRK10555 1045856010365 Protein export membrane protein; Region: SecD_SecF; cl14618 1045856010366 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 1045856010367 ArsC family; Region: ArsC; pfam03960 1045856010368 putative catalytic residues [active] 1045856010369 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 1045856010370 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 1045856010371 metal binding site [ion binding]; metal-binding site 1045856010372 dimer interface [polypeptide binding]; other site 1045856010373 hypothetical protein; Provisional; Region: PRK13664 1045856010374 putative hydrolase; Provisional; Region: PRK11460 1045856010375 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 1045856010376 Predicted P-loop ATPase fused to an acetyltransferase [General function prediction only]; Region: COG1444 1045856010377 Helicase; Region: Helicase_RecD; pfam05127 1045856010378 GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718 1045856010379 Possible tRNA binding domain; Region: tRNA_bind_2; pfam13725 1045856010380 Predicted metalloprotease [General function prediction only]; Region: COG2321 1045856010381 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 1045856010382 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 1045856010383 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 1045856010384 ATP binding site [chemical binding]; other site 1045856010385 active site 1045856010386 substrate binding site [chemical binding]; other site 1045856010387 lipoprotein; Provisional; Region: PRK11679 1045856010388 NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804 1045856010389 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1045856010390 dihydrodipicolinate synthase; Region: dapA; TIGR00674 1045856010391 dimer interface [polypeptide binding]; other site 1045856010392 active site 1045856010393 catalytic residue [active] 1045856010394 glycine cleavage system transcriptional repressor; Provisional; Region: gcvR; PRK11589 1045856010395 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_1; cd04893 1045856010396 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1045856010397 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1045856010398 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1045856010399 catalytic triad [active] 1045856010400 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1045856010401 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1045856010402 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 1045856010403 Peptidase family M48; Region: Peptidase_M48; cl12018 1045856010404 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 1045856010405 ArsC family; Region: ArsC; pfam03960 1045856010406 catalytic residues [active] 1045856010407 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1045856010408 Helix-turn-helix XRE-family like proteins; Region: HTH_XRE; smart00530 1045856010409 non-specific DNA binding site [nucleotide binding]; other site 1045856010410 salt bridge; other site 1045856010411 sequence-specific DNA binding site [nucleotide binding]; other site 1045856010412 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 1045856010413 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1045856010414 Glycosylasparaginase catalyzes the hydrolysis of the glycosylamide bond of asparagine-linked glycoproteins. This enzyme is an amidase located inside lysosomes. Mutation of this gene in humans causes a genetic disorder known as aspartylglycosaminuria (AGU)...; Region: Glycosylasparaginase; cd04513 1045856010415 active site 1045856010416 dimer interface [polypeptide binding]; other site 1045856010417 catalytic nucleophile [active] 1045856010418 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1045856010419 Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260 1045856010420 interface (dimer of trimers) [polypeptide binding]; other site 1045856010421 Substrate-binding/catalytic site; other site 1045856010422 Zn-binding sites [ion binding]; other site 1045856010423 DNA replication initiation factor; Provisional; Region: PRK08084 1045856010424 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 1045856010425 uracil transporter; Provisional; Region: PRK10720 1045856010426 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1045856010427 active site 1045856010428 6-phospho-beta-glucosidase; Reviewed; Region: celA; PRK09589 1045856010429 beta-galactosidase; Region: BGL; TIGR03356 1045856010430 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 1045856010431 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 1045856010432 dimerization interface [polypeptide binding]; other site 1045856010433 putative ATP binding site [chemical binding]; other site 1045856010434 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 1045856010435 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 1045856010436 active site 1045856010437 substrate binding site [chemical binding]; other site 1045856010438 cosubstrate binding site; other site 1045856010439 catalytic site [active] 1045856010440 Polyphosphate kinase [Inorganic ion transport and metabolism]; Region: Ppk; COG0855 1045856010441 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 1045856010442 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 1045856010443 Catalytic C-terminal domain, first repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C1_like; cd09164 1045856010444 domain interface [polypeptide binding]; other site 1045856010445 active site 1045856010446 catalytic site [active] 1045856010447 Catalytic C-terminal domain, second repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C2_like; cd09167 1045856010448 domain interface [polypeptide binding]; other site 1045856010449 active site 1045856010450 catalytic site [active] 1045856010451 exopolyphosphatase; Provisional; Region: PRK10854 1045856010452 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1045856010453 MASE1; Region: MASE1; pfam05231 1045856010454 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1045856010455 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 1045856010456 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1045856010457 Protein of unknown function (DUF2633); Region: DUF2633; pfam11119 1045856010458 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1045856010459 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1045856010460 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1045856010461 dimerization interface [polypeptide binding]; other site 1045856010462 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1045856010463 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1045856010464 putative substrate translocation pore; other site 1045856010465 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1045856010466 Predicted transcriptional regulators [Transcription]; Region: COG1733 1045856010467 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1045856010468 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1045856010469 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1045856010470 putative substrate translocation pore; other site 1045856010471 Uncharacterized enzyme involved in inositol metabolism [Carbohydrate transport and metabolism]; Region: IolB; COG3718 1045856010472 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1045856010473 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1045856010474 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1045856010475 substrate binding site [chemical binding]; other site 1045856010476 ATP binding site [chemical binding]; other site 1045856010477 Uncharacterized protein conserved in bacteria (DUF2090); Region: DUF2090; pfam09863 1045856010478 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3892 1045856010479 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1045856010480 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1045856010481 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1045856010482 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1045856010483 TM-ABC transporter signature motif; other site 1045856010484 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1045856010485 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1045856010486 Walker A/P-loop; other site 1045856010487 ATP binding site [chemical binding]; other site 1045856010488 Q-loop/lid; other site 1045856010489 ABC transporter signature motif; other site 1045856010490 Walker B; other site 1045856010491 D-loop; other site 1045856010492 H-loop/switch region; other site 1045856010493 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1045856010494 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 1045856010495 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1045856010496 ligand binding site [chemical binding]; other site 1045856010497 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1045856010498 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1045856010499 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1045856010500 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 1045856010501 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1045856010502 PYR/PP interface [polypeptide binding]; other site 1045856010503 dimer interface [polypeptide binding]; other site 1045856010504 TPP binding site [chemical binding]; other site 1045856010505 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1045856010506 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 1045856010507 TPP-binding site; other site 1045856010508 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 1045856010509 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 1045856010510 tetrameric interface [polypeptide binding]; other site 1045856010511 NAD binding site [chemical binding]; other site 1045856010512 catalytic residues [active] 1045856010513 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1045856010514 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1045856010515 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1045856010516 putative active site [active] 1045856010517 GMP synthase; Reviewed; Region: guaA; PRK00074 1045856010518 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1045856010519 AMP/PPi binding site [chemical binding]; other site 1045856010520 candidate oxyanion hole; other site 1045856010521 catalytic triad [active] 1045856010522 potential glutamine specificity residues [chemical binding]; other site 1045856010523 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1045856010524 ATP Binding subdomain [chemical binding]; other site 1045856010525 Ligand Binding sites [chemical binding]; other site 1045856010526 Dimerization subdomain; other site 1045856010527 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 1045856010528 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1045856010529 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 1045856010530 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1045856010531 active site 1045856010532 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 1045856010533 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 1045856010534 generic binding surface II; other site 1045856010535 generic binding surface I; other site 1045856010536 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 1045856010537 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 1045856010538 active site 1045856010539 Zn binding site [ion binding]; other site 1045856010540 Protein of unknown function (DUF1407); Region: DUF1407; pfam07191 1045856010541 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1045856010542 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1045856010543 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1045856010544 putative substrate translocation pore; other site 1045856010545 POT family; Region: PTR2; cl17359 1045856010546 GTP-binding protein Der; Reviewed; Region: PRK00093 1045856010547 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1045856010548 G1 box; other site 1045856010549 GTP/Mg2+ binding site [chemical binding]; other site 1045856010550 Switch I region; other site 1045856010551 G2 box; other site 1045856010552 Switch II region; other site 1045856010553 G3 box; other site 1045856010554 G4 box; other site 1045856010555 G5 box; other site 1045856010556 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1045856010557 G1 box; other site 1045856010558 GTP/Mg2+ binding site [chemical binding]; other site 1045856010559 Switch I region; other site 1045856010560 G2 box; other site 1045856010561 G3 box; other site 1045856010562 Switch II region; other site 1045856010563 G4 box; other site 1045856010564 G5 box; other site 1045856010565 outer membrane biogenesis protein BamB; Provisional; Region: PRK11138 1045856010566 Beta-barrel assembly machinery (Bam) complex component B and related proteins; Region: BamB_YfgL; cd10276 1045856010567 Trp docking motif [polypeptide binding]; other site 1045856010568 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 1045856010569 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 1045856010570 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1045856010571 dimer interface [polypeptide binding]; other site 1045856010572 motif 1; other site 1045856010573 active site 1045856010574 motif 2; other site 1045856010575 motif 3; other site 1045856010576 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1045856010577 anticodon binding site; other site 1045856010578 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 1045856010579 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1045856010580 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1045856010581 cytoskeletal protein RodZ; Provisional; Region: PRK10856 1045856010582 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1045856010583 non-specific DNA binding site [nucleotide binding]; other site 1045856010584 salt bridge; other site 1045856010585 sequence-specific DNA binding site [nucleotide binding]; other site 1045856010586 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 1045856010587 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 1045856010588 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1045856010589 FeS/SAM binding site; other site 1045856010590 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 1045856010591 active site 1045856010592 multimer interface [polypeptide binding]; other site 1045856010593 penicillin-binding protein 1C; Provisional; Region: PRK11240 1045856010594 Transglycosylase; Region: Transgly; pfam00912 1045856010595 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1045856010596 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 1045856010597 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 1045856010598 MG2 domain; Region: A2M_N; pfam01835 1045856010599 Alpha-2-macroglobulin family; Region: A2M; pfam00207 1045856010600 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 1045856010601 surface patch; other site 1045856010602 thioester region; other site 1045856010603 specificity defining residues; other site 1045856010604 bifunctional PTS system maltose and glucose-specific transporter subunits IICB; Provisional; Region: PRK10110 1045856010605 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1045856010606 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1045856010607 active site turn [active] 1045856010608 phosphorylation site [posttranslational modification] 1045856010609 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 1045856010610 Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298 1045856010611 NAD binding site [chemical binding]; other site 1045856010612 sugar binding site [chemical binding]; other site 1045856010613 divalent metal binding site [ion binding]; other site 1045856010614 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 1045856010615 dimer interface [polypeptide binding]; other site 1045856010616 3-mercaptopyruvate sulfurtransferase; Provisional; Region: sseA; PRK11493 1045856010617 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1045856010618 active site residue [active] 1045856010619 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1045856010620 active site residue [active] 1045856010621 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1045856010622 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1045856010623 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1045856010624 putative active site [active] 1045856010625 enhanced serine sensitivity protein SseB; Provisional; Region: PRK11611 1045856010626 aminopeptidase B; Provisional; Region: PRK05015 1045856010627 Peptidase; Region: DUF3663; pfam12404 1045856010628 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1045856010629 interface (dimer of trimers) [polypeptide binding]; other site 1045856010630 Substrate-binding/catalytic site; other site 1045856010631 Zn-binding sites [ion binding]; other site 1045856010632 hypothetical protein; Provisional; Region: PRK10721 1045856010633 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1045856010634 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1045856010635 catalytic loop [active] 1045856010636 iron binding site [ion binding]; other site 1045856010637 chaperone protein HscA; Provisional; Region: hscA; PRK05183 1045856010638 Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236 1045856010639 nucleotide binding site [chemical binding]; other site 1045856010640 putative NEF/HSP70 interaction site [polypeptide binding]; other site 1045856010641 SBD interface [polypeptide binding]; other site 1045856010642 co-chaperone HscB; Provisional; Region: hscB; PRK05014 1045856010643 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1045856010644 HSP70 interaction site [polypeptide binding]; other site 1045856010645 HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743 1045856010646 iron-sulfur cluster assembly protein; Provisional; Region: iscA; PRK09502 1045856010647 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 1045856010648 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1045856010649 trimerization site [polypeptide binding]; other site 1045856010650 active site 1045856010651 cysteine desulfurase; Provisional; Region: PRK14012 1045856010652 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1045856010653 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1045856010654 catalytic residue [active] 1045856010655 Transcriptional regulator; Region: Rrf2; cl17282 1045856010656 Rrf2 family protein; Region: rrf2_super; TIGR00738 1045856010657 tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ; Provisional; Region: PRK15114 1045856010658 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 1045856010659 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1045856010660 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 1045856010661 active site 1045856010662 dimerization interface [polypeptide binding]; other site 1045856010663 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG2215 1045856010664 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG3683 1045856010665 stationary phase inducible protein CsiE; Provisional; Region: PRK11564 1045856010666 PRD domain; Region: PRD; pfam00874 1045856010667 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 1045856010668 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1045856010669 putative substrate translocation pore; other site 1045856010670 Predicted membrane protein [Function unknown]; Region: COG2259 1045856010671 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1045856010672 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1045856010673 dimer interface [polypeptide binding]; other site 1045856010674 active site 1045856010675 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1045856010676 folate binding site [chemical binding]; other site 1045856010677 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 1045856010678 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 1045856010679 heme-binding site [chemical binding]; other site 1045856010680 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 1045856010681 FAD binding pocket [chemical binding]; other site 1045856010682 FAD binding motif [chemical binding]; other site 1045856010683 phosphate binding motif [ion binding]; other site 1045856010684 beta-alpha-beta structure motif; other site 1045856010685 NAD binding pocket [chemical binding]; other site 1045856010686 Heme binding pocket [chemical binding]; other site 1045856010687 nitrogen regulatory protein P-II 1; Provisional; Region: PRK10858 1045856010688 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1045856010689 response regulator GlrR; Provisional; Region: PRK15115 1045856010690 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1045856010691 active site 1045856010692 phosphorylation site [posttranslational modification] 1045856010693 intermolecular recognition site; other site 1045856010694 dimerization interface [polypeptide binding]; other site 1045856010695 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1045856010696 Walker A motif; other site 1045856010697 ATP binding site [chemical binding]; other site 1045856010698 Walker B motif; other site 1045856010699 arginine finger; other site 1045856010700 hypothetical protein; Provisional; Region: PRK10722 1045856010701 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1045856010702 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1045856010703 dimer interface [polypeptide binding]; other site 1045856010704 phosphorylation site [posttranslational modification] 1045856010705 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1045856010706 ATP binding site [chemical binding]; other site 1045856010707 Mg2+ binding site [ion binding]; other site 1045856010708 G-X-G motif; other site 1045856010709 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 1045856010710 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 1045856010711 dimerization interface [polypeptide binding]; other site 1045856010712 ATP binding site [chemical binding]; other site 1045856010713 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 1045856010714 dimerization interface [polypeptide binding]; other site 1045856010715 ATP binding site [chemical binding]; other site 1045856010716 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 1045856010717 putative active site [active] 1045856010718 catalytic triad [active] 1045856010719 membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859 1045856010720 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1045856010721 substrate binding pocket [chemical binding]; other site 1045856010722 membrane-bound complex binding site; other site 1045856010723 hinge residues; other site 1045856010724 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1045856010725 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1045856010726 catalytic residue [active] 1045856010727 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1045856010728 nucleoside/Zn binding site; other site 1045856010729 dimer interface [polypeptide binding]; other site 1045856010730 catalytic motif [active] 1045856010731 hypothetical protein; Provisional; Region: PRK11590 1045856010732 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1045856010733 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 1045856010734 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1045856010735 active site turn [active] 1045856010736 phosphorylation site [posttranslational modification] 1045856010737 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1045856010738 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 1045856010739 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 1045856010740 putative active site [active] 1045856010741 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1045856010742 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11557 1045856010743 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1045856010744 putative active site [active] 1045856010745 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 1045856010746 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 1045856010747 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 1045856010748 active site 1045856010749 hydrophilic channel; other site 1045856010750 dimerization interface [polypeptide binding]; other site 1045856010751 catalytic residues [active] 1045856010752 active site lid [active] 1045856010753 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 1045856010754 Recombination protein O N terminal; Region: RecO_N; pfam11967 1045856010755 Recombination protein O C terminal; Region: RecO_C; pfam02565 1045856010756 GTPase Era; Reviewed; Region: era; PRK00089 1045856010757 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1045856010758 G1 box; other site 1045856010759 GTP/Mg2+ binding site [chemical binding]; other site 1045856010760 Switch I region; other site 1045856010761 G2 box; other site 1045856010762 Switch II region; other site 1045856010763 G3 box; other site 1045856010764 G4 box; other site 1045856010765 G5 box; other site 1045856010766 KH domain; Region: KH_2; pfam07650 1045856010767 ribonuclease III; Reviewed; Region: rnc; PRK00102 1045856010768 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1045856010769 dimerization interface [polypeptide binding]; other site 1045856010770 active site 1045856010771 metal binding site [ion binding]; metal-binding site 1045856010772 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1045856010773 dsRNA binding site [nucleotide binding]; other site 1045856010774 signal peptidase I; Provisional; Region: PRK10861 1045856010775 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1045856010776 Catalytic site [active] 1045856010777 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1045856010778 GTP-binding protein LepA; Provisional; Region: PRK05433 1045856010779 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1045856010780 G1 box; other site 1045856010781 putative GEF interaction site [polypeptide binding]; other site 1045856010782 GTP/Mg2+ binding site [chemical binding]; other site 1045856010783 Switch I region; other site 1045856010784 G2 box; other site 1045856010785 G3 box; other site 1045856010786 Switch II region; other site 1045856010787 G4 box; other site 1045856010788 G5 box; other site 1045856010789 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 1045856010790 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1045856010791 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1045856010792 SoxR reducing system protein RseC; Provisional; Region: PRK10862 1045856010793 Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026 1045856010794 anti-sigma E factor; Provisional; Region: rseB; PRK09455 1045856010795 anti-RNA polymerase sigma factor SigE; Provisional; Region: PRK10863 1045856010796 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 1045856010797 Anti sigma-E protein RseA, C-terminal domain; Region: RseA_C; pfam03873 1045856010798 RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939 1045856010799 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1045856010800 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1045856010801 DNA binding residues [nucleotide binding] 1045856010802 L-aspartate oxidase; Provisional; Region: PRK09077 1045856010803 L-aspartate oxidase; Provisional; Region: PRK06175 1045856010804 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1045856010805 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 1045856010806 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1045856010807 S-adenosylmethionine binding site [chemical binding]; other site 1045856010808 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 1045856010809 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1045856010810 ATP binding site [chemical binding]; other site 1045856010811 Mg++ binding site [ion binding]; other site 1045856010812 motif III; other site 1045856010813 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1045856010814 nucleotide binding region [chemical binding]; other site 1045856010815 ATP-binding site [chemical binding]; other site 1045856010816 autonomous glycyl radical cofactor GrcA; Provisional; Region: PRK11127 1045856010817 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 1045856010818 ligand binding site [chemical binding]; other site 1045856010819 active site 1045856010820 UGI interface [polypeptide binding]; other site 1045856010821 catalytic site [active] 1045856010822 putative methyltransferase; Provisional; Region: PRK10864 1045856010823 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 1045856010824 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1045856010825 thioredoxin 2; Provisional; Region: PRK10996 1045856010826 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 1045856010827 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1045856010828 catalytic residues [active] 1045856010829 Uncharacterized conserved protein [Function unknown]; Region: COG3148 1045856010830 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 1045856010831 CoA binding domain; Region: CoA_binding_2; pfam13380 1045856010832 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 1045856010833 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 1045856010834 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1045856010835 phosphatidylserine synthase; Provisional; Region: pssA; PRK09428 1045856010836 Catalytic domain, repeat 1, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_1; cd09134 1045856010837 domain interface [polypeptide binding]; other site 1045856010838 putative active site [active] 1045856010839 catalytic site [active] 1045856010840 Catalytic domain, repeat 2, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_2; cd09136 1045856010841 domain interface [polypeptide binding]; other site 1045856010842 putative active site [active] 1045856010843 catalytic site [active] 1045856010844 lipoprotein; Provisional; Region: PRK10759 1045856010845 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 1045856010846 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1045856010847 putative substrate translocation pore; other site 1045856010848 protein disaggregation chaperone; Provisional; Region: PRK10865 1045856010849 Clp amino terminal domain; Region: Clp_N; pfam02861 1045856010850 Clp amino terminal domain; Region: Clp_N; pfam02861 1045856010851 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1045856010852 Walker A motif; other site 1045856010853 ATP binding site [chemical binding]; other site 1045856010854 Walker B motif; other site 1045856010855 arginine finger; other site 1045856010856 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1045856010857 Walker A motif; other site 1045856010858 ATP binding site [chemical binding]; other site 1045856010859 Walker B motif; other site 1045856010860 arginine finger; other site 1045856010861 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1045856010862 hypothetical protein; Provisional; Region: PRK10723 1045856010863 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 1045856010864 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 1045856010865 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1045856010866 RNA binding surface [nucleotide binding]; other site 1045856010867 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1045856010868 active site 1045856010869 outer membrane biogenesis protein BamD; Provisional; Region: PRK10866 1045856010870 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1045856010871 30S subunit binding site; other site 1045856010872 bifunctional chorismate mutase/prephenate dehydratase; Provisional; Region: pheA; PRK10622 1045856010873 chorismate mutase domain of proteobacterial P-protein, clade 1; Region: CM_P_1; TIGR01797 1045856010874 Prephenate dehydratase; Region: PDT; pfam00800 1045856010875 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 1045856010876 putative L-Phe binding site [chemical binding]; other site 1045856010877 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 1045856010878 bifunctional chorismate mutase/prephenate dehydrogenase; Provisional; Region: tyrA; PRK11199 1045856010879 Chorismate mutase type II; Region: CM_2; cl00693 1045856010880 prephenate dehydrogenase; Validated; Region: PRK08507 1045856010881 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 1045856010882 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1045856010883 lipoprotein; Provisional; Region: PRK11443 1045856010884 Protein of unknown function (DUF2799); Region: DUF2799; pfam10973 1045856010885 Domain of unknown function (DUF4154); Region: DUF4154; pfam13689 1045856010886 putative inner membrane diguanylate cyclase; Provisional; Region: PRK09966 1045856010887 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1045856010888 metal binding site [ion binding]; metal-binding site 1045856010889 active site 1045856010890 I-site; other site 1045856010891 putative outer membrane lipoprotein; Provisional; Region: PRK09967 1045856010892 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1045856010893 ligand binding site [chemical binding]; other site 1045856010894 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 1045856010895 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 1045856010896 Protein of unknown function (DUF2946); Region: DUF2946; pfam11162 1045856010897 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 1045856010898 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 1045856010899 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 1045856010900 RimM N-terminal domain; Region: RimM; pfam01782 1045856010901 PRC-barrel domain; Region: PRC; pfam05239 1045856010902 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 1045856010903 signal recognition particle protein; Provisional; Region: PRK10867 1045856010904 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1045856010905 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1045856010906 P loop; other site 1045856010907 GTP binding site [chemical binding]; other site 1045856010908 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1045856010909 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4137 1045856010910 hypothetical protein; Provisional; Region: PRK11573 1045856010911 Domain of unknown function DUF21; Region: DUF21; pfam01595 1045856010912 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1045856010913 Transporter associated domain; Region: CorC_HlyC; smart01091 1045856010914 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 1045856010915 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1045856010916 dimer interface [polypeptide binding]; other site 1045856010917 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1045856010918 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03378 1045856010919 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 1045856010920 recombination and repair protein; Provisional; Region: PRK10869 1045856010921 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1045856010922 Walker A/P-loop; other site 1045856010923 ATP binding site [chemical binding]; other site 1045856010924 Q-loop/lid; other site 1045856010925 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1045856010926 ABC transporter signature motif; other site 1045856010927 Walker B; other site 1045856010928 D-loop; other site 1045856010929 H-loop/switch region; other site 1045856010930 outer membrane biogenesis protein BamE; Provisional; Region: PRK11548 1045856010931 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 1045856010932 hypothetical protein; Validated; Region: PRK01777 1045856010933 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 1045856010934 putative coenzyme Q binding site [chemical binding]; other site 1045856010935 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1045856010936 SmpB-tmRNA interface; other site 1045856010937 integrase; Provisional; Region: PRK09692 1045856010938 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 1045856010939 active site 1045856010940 Int/Topo IB signature motif; other site 1045856010941 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1045856010942 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 1045856010943 catalytic residues [active] 1045856010944 catalytic nucleophile [active] 1045856010945 Recombinase; Region: Recombinase; pfam07508 1045856010946 ParB-like nuclease domain; Region: ParBc; pfam02195 1045856010947 RepB plasmid partitioning protein; Region: RepB; pfam07506 1045856010948 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 1045856010949 ParB-like nuclease domain; Region: ParB; smart00470 1045856010950 RepB plasmid partitioning protein; Region: RepB; pfam07506 1045856010951 RES domain; Region: RES; pfam08808 1045856010952 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 1045856010953 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4688 1045856010954 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1045856010955 active site 1045856010956 catalytic residues [active] 1045856010957 DNA binding site [nucleotide binding] 1045856010958 Int/Topo IB signature motif; other site 1045856010959 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1045856010960 active site 1045856010961 catalytic residues [active] 1045856010962 DNA binding site [nucleotide binding] 1045856010963 Int/Topo IB signature motif; other site 1045856010964 Cupin domain; Region: Cupin_2; cl17218 1045856010965 YceI-like domain; Region: YceI; pfam04264 1045856010966 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 1045856010967 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1045856010968 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1045856010969 DNA binding residues [nucleotide binding] 1045856010970 Chitin binding Peritrophin-A domain; Region: CBM_14; cl02629 1045856010971 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1045856010972 binding surface 1045856010973 TPR motif; other site 1045856010974 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1045856010975 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1045856010976 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1045856010977 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1045856010978 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1045856010979 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1045856010980 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1045856010981 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1045856010982 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1045856010983 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1045856010984 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1045856010985 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1045856010986 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1045856010987 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1045856010988 type I secretion C-terminal target domain (VC_A0849 subclass); Region: T1SS_VCA0849; TIGR03661 1045856010989 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 1045856010990 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 1045856010991 putative active site [active] 1045856010992 type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375 1045856010993 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1045856010994 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1045856010995 Walker A/P-loop; other site 1045856010996 ATP binding site [chemical binding]; other site 1045856010997 Q-loop/lid; other site 1045856010998 ABC transporter signature motif; other site 1045856010999 Walker B; other site 1045856011000 D-loop; other site 1045856011001 H-loop/switch region; other site 1045856011002 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 1045856011003 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1045856011004 HlyD family secretion protein; Region: HlyD_3; pfam13437 1045856011005 nucleoside triphosphatase NudI; Provisional; Region: PRK15472 1045856011006 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1045856011007 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1045856011008 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1045856011009 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 1045856011010 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1045856011011 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1045856011012 homodimer interface [polypeptide binding]; other site 1045856011013 catalytic residue [active] 1045856011014 transcriptional regulator; Provisional; Region: PRK10632 1045856011015 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1045856011016 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1045856011017 dimerization interface [polypeptide binding]; other site 1045856011018 Lin1944 and related proteins, classical (c) SDRs; Region: Lin1944_like_SDR_c; cd11731 1045856011019 putative NAD(P) binding site [chemical binding]; other site 1045856011020 homodimer interface [polypeptide binding]; other site 1045856011021 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1045856011022 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1045856011023 S-adenosylmethionine binding site [chemical binding]; other site 1045856011024 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 1045856011025 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1045856011026 PYR/PP interface [polypeptide binding]; other site 1045856011027 dimer interface [polypeptide binding]; other site 1045856011028 TPP binding site [chemical binding]; other site 1045856011029 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1045856011030 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1045856011031 TPP-binding site [chemical binding]; other site 1045856011032 dimer interface [polypeptide binding]; other site 1045856011033 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1045856011034 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1045856011035 NAD(P) binding site [chemical binding]; other site 1045856011036 active site 1045856011037 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1045856011038 D-galactonate transporter; Region: 2A0114; TIGR00893 1045856011039 putative substrate translocation pore; other site 1045856011040 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1045856011041 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1045856011042 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1045856011043 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 1045856011044 dimerization interface [polypeptide binding]; other site 1045856011045 substrate binding pocket [chemical binding]; other site 1045856011046 putative deaminase; Validated; Region: PRK06846 1045856011047 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 1045856011048 active site 1045856011049 carbamate kinase; Reviewed; Region: PRK12686 1045856011050 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 1045856011051 putative substrate binding site [chemical binding]; other site 1045856011052 nucleotide binding site [chemical binding]; other site 1045856011053 nucleotide binding site [chemical binding]; other site 1045856011054 homodimer interface [polypeptide binding]; other site 1045856011055 Protein of unknown function (DUF1116); Region: DUF1116; pfam06545 1045856011056 Succinyl-CoA synthetase, alpha subunit [Energy production and conversion]; Region: SucD; COG0074 1045856011057 CoA binding domain; Region: CoA_binding; pfam02629 1045856011058 CoA-ligase; Region: Ligase_CoA; pfam00549 1045856011059 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1045856011060 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1045856011061 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1045856011062 DNA-binding transcriptional activator AllS; Provisional; Region: PRK10094 1045856011063 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1045856011064 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1045856011065 dimerization interface [polypeptide binding]; other site 1045856011066 Uncharacterized homolog of Blt101 [Function unknown]; Region: COG0401 1045856011067 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1045856011068 dimerization interface [polypeptide binding]; other site 1045856011069 putative DNA binding site [nucleotide binding]; other site 1045856011070 putative Zn2+ binding site [ion binding]; other site 1045856011071 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 1045856011072 active site residue [active] 1045856011073 DNA binding protein, nucleoid-associated; Provisional; Region: PRK10328 1045856011074 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 1045856011075 Protein of unknown function (DUF1144); Region: DUF1144; pfam06610 1045856011076 hypothetical protein; Provisional; Region: PRK10556 1045856011077 hypothetical protein; Provisional; Region: PRK10132 1045856011078 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 1045856011079 catalytic residues [active] 1045856011080 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 1045856011081 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 1045856011082 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 1045856011083 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1045856011084 active site 1045856011085 dimer interface [polypeptide binding]; other site 1045856011086 catalytic residues [active] 1045856011087 effector binding site; other site 1045856011088 R2 peptide binding site; other site 1045856011089 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 1045856011090 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1045856011091 dimer interface [polypeptide binding]; other site 1045856011092 putative radical transfer pathway; other site 1045856011093 diiron center [ion binding]; other site 1045856011094 tyrosyl radical; other site 1045856011095 glycine betaine transporter ATP-binding subunit; Provisional; Region: PRK10070 1045856011096 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 1045856011097 Walker A/P-loop; other site 1045856011098 ATP binding site [chemical binding]; other site 1045856011099 Q-loop/lid; other site 1045856011100 ABC transporter signature motif; other site 1045856011101 Walker B; other site 1045856011102 D-loop; other site 1045856011103 H-loop/switch region; other site 1045856011104 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 1045856011105 glycine betaine transporter membrane protein; Provisional; Region: PRK10952 1045856011106 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1045856011107 dimer interface [polypeptide binding]; other site 1045856011108 conserved gate region; other site 1045856011109 putative PBP binding loops; other site 1045856011110 ABC-ATPase subunit interface; other site 1045856011111 glycine betaine transporter periplasmic subunit; Provisional; Region: proX; PRK11119 1045856011112 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1045856011113 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1045856011114 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1045856011115 transcriptional repressor MprA; Provisional; Region: PRK10870 1045856011116 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1045856011117 multidrug efflux system protein EmrA; Provisional; Region: PRK15136 1045856011118 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1045856011119 HlyD family secretion protein; Region: HlyD_3; pfam13437 1045856011120 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1045856011121 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1045856011122 putative substrate translocation pore; other site 1045856011123 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1045856011124 2-isopropylmalate synthase; Validated; Region: PRK03739 1045856011125 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 1045856011126 active site 1045856011127 catalytic residues [active] 1045856011128 metal binding site [ion binding]; metal-binding site 1045856011129 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 1045856011130 Cupin domain; Region: Cupin_2; pfam07883 1045856011131 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1045856011132 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1045856011133 S-ribosylhomocysteinase; Provisional; Region: PRK02260 1045856011134 glutamate--cysteine ligase; Provisional; Region: PRK02107 1045856011135 Predicted membrane protein [Function unknown]; Region: COG1238 1045856011136 fructose-1-P/6-phosphogluconate phosphatase; Provisional; Region: PRK10725 1045856011137 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1045856011138 motif II; other site 1045856011139 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1045856011140 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 1045856011141 motif 1; other site 1045856011142 active site 1045856011143 motif 2; other site 1045856011144 motif 3; other site 1045856011145 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1045856011146 DHHA1 domain; Region: DHHA1; pfam02272 1045856011147 recombination regulator RecX; Reviewed; Region: recX; PRK00117 1045856011148 recombinase A; Provisional; Region: recA; PRK09354 1045856011149 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1045856011150 hexamer interface [polypeptide binding]; other site 1045856011151 Walker A motif; other site 1045856011152 ATP binding site [chemical binding]; other site 1045856011153 Walker B motif; other site 1045856011154 hypothetical protein; Validated; Region: PRK03661 1045856011155 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 1045856011156 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 1045856011157 metal binding site [ion binding]; metal-binding site 1045856011158 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1045856011159 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1045856011160 ABC-ATPase subunit interface; other site 1045856011161 dimer interface [polypeptide binding]; other site 1045856011162 putative PBP binding regions; other site 1045856011163 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1045856011164 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1045856011165 Transglycosylase SLT domain; Region: SLT_2; pfam13406 1045856011166 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1045856011167 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1045856011168 catalytic residue [active] 1045856011169 PTS system enzyme II sorbitol-specific factor; Region: EII-GUT; cl01515 1045856011170 PTS system, glucitol/sorbitol-specific, IIBC component; Region: EIIBC-GUT; TIGR00825 1045856011171 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 1045856011172 Nucleoside recognition; Region: Gate; pfam07670 1045856011173 Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663 1045856011174 PTS system glucitol/sorbitol-specific transporter subunit IIA; Provisional; Region: PRK10377 1045856011175 sorbitol-6-phosphate dehydrogenase; Provisional; Region: PRK12384 1045856011176 Sorbitol 6-phosphate dehydrogenase (SDH), classical (c) SDRs; Region: SDH_SDR_c_like; cd05322 1045856011177 putative NAD(P) binding site [chemical binding]; other site 1045856011178 active site 1045856011179 DNA-binding transcriptional activator GutM; Provisional; Region: PRK10234 1045856011180 DNA-bindng transcriptional repressor SrlR; Provisional; Region: srlR; PRK10434 1045856011181 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1045856011182 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1045856011183 D-arabinose 5-phosphate isomerase; Provisional; Region: gutQ; PRK11543 1045856011184 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 1045856011185 putative active site [active] 1045856011186 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 1045856011187 anaerobic nitric oxide reductase transcription regulator; Provisional; Region: PRK05022 1045856011188 GAF domain; Region: GAF; pfam01590 1045856011189 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1045856011190 Walker A motif; other site 1045856011191 ATP binding site [chemical binding]; other site 1045856011192 Walker B motif; other site 1045856011193 arginine finger; other site 1045856011194 anaerobic nitric oxide reductase flavorubredoxin; Provisional; Region: PRK05452 1045856011195 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1045856011196 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1045856011197 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 1045856011198 iron binding site [ion binding]; other site 1045856011199 NADH:flavorubredoxin oxidoreductase; Provisional; Region: PRK04965 1045856011200 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1045856011201 High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376 1045856011202 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 1045856011203 Acylphosphatase; Region: Acylphosphatase; pfam00708 1045856011204 HypF finger; Region: zf-HYPF; pfam07503 1045856011205 HypF finger; Region: zf-HYPF; pfam07503 1045856011206 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 1045856011207 formate dehydrogenase-H ferredoxin subunit; Provisional; Region: PRK10330 1045856011208 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 1045856011209 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1045856011210 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1045856011211 DNA binding site [nucleotide binding] 1045856011212 domain linker motif; other site 1045856011213 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 1045856011214 dimerization interface (closed form) [polypeptide binding]; other site 1045856011215 ligand binding site [chemical binding]; other site 1045856011216 PTS system cellobiose/arbutin/salicin-specific transporter subunits IIBC; Provisional; Region: PRK09796 1045856011217 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1045856011218 active site turn [active] 1045856011219 phosphorylation site [posttranslational modification] 1045856011220 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 1045856011221 cryptic 6-phospho-beta-glucosidase; Provisional; Region: PRK09852 1045856011222 beta-galactosidase; Region: BGL; TIGR03356 1045856011223 Endopeptidases belonging to membrane-bound hydrogen evolving hydrogenase group. In hydrogenase 3 from E coli, the maturation of the large subunit (HycE) requires the cleavage of a C-terminal peptide by the endopeptidase HycI, before the final formation...; Region: H2MP_MemB-H2evol; cd06067 1045856011224 nickel binding site [ion binding]; other site 1045856011225 formate hydrogenlyase maturation protein HycH; Provisional; Region: PRK15084 1045856011226 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 1045856011227 formate hydrogenlyase complex iron-sulfur subunit; Provisional; Region: PRK12387 1045856011228 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1045856011229 Ni,Fe-hydrogenase III component G [Energy production and conversion]; Region: HycE; COG3262 1045856011230 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 1045856011231 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 1045856011232 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 1045856011233 NADH dehydrogenase; Region: NADHdh; cl00469 1045856011234 formate hydrogenlyase subunit 3; Reviewed; Region: PRK08042 1045856011235 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1045856011236 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 1045856011237 formate hydrogenlyase regulatory protein HycA; Provisional; Region: PRK10198 1045856011238 Hydrogenase expression/synthesis hypA family; Region: HypA; cl17671 1045856011239 hydrogenase nickel incorporation protein; Validated; Region: hypA; PRK03681 1045856011240 hydrogenase nickel incorporation protein HypB; Provisional; Region: PRK10463 1045856011241 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1045856011242 hydrogenase assembly chaperone; Provisional; Region: PRK10409 1045856011243 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 1045856011244 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 1045856011245 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 1045856011246 dimerization interface [polypeptide binding]; other site 1045856011247 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 1045856011248 ATP binding site [chemical binding]; other site 1045856011249 formate hydrogenlyase transcriptional activator FhlA; Provisional; Region: PRK15429 1045856011250 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1045856011251 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1045856011252 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1045856011253 Walker A motif; other site 1045856011254 ATP binding site [chemical binding]; other site 1045856011255 Walker B motif; other site 1045856011256 arginine finger; other site 1045856011257 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1045856011258 Nitrous oxide-stimulated promoter; Region: YgbA_NO; pfam11756 1045856011259 Toxin SymE, type I toxin-antitoxin system; Region: SymE_toxin; pfam08845 1045856011260 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 1045856011261 MutS domain I; Region: MutS_I; pfam01624 1045856011262 MutS domain II; Region: MutS_II; pfam05188 1045856011263 MutS domain III; Region: MutS_III; pfam05192 1045856011264 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 1045856011265 Walker A/P-loop; other site 1045856011266 ATP binding site [chemical binding]; other site 1045856011267 Q-loop/lid; other site 1045856011268 ABC transporter signature motif; other site 1045856011269 Walker B; other site 1045856011270 D-loop; other site 1045856011271 H-loop/switch region; other site 1045856011272 Protein of unknown function (DUF1062); Region: DUF1062; cl01786 1045856011273 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases [Coenzyme metabolism]; Region: UbiD; COG0043 1045856011274 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 1045856011275 Flavoprotein; Region: Flavoprotein; pfam02441 1045856011276 MarR family; Region: MarR_2; cl17246 1045856011277 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1045856011278 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1045856011279 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1045856011280 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1045856011281 putative effector binding pocket; other site 1045856011282 dimerization interface [polypeptide binding]; other site 1045856011283 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1045856011284 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1045856011285 putative substrate translocation pore; other site 1045856011286 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4460 1045856011287 RNA polymerase sigma factor RpoS; Validated; Region: PRK05657 1045856011288 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1045856011289 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1045856011290 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1045856011291 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1045856011292 DNA binding residues [nucleotide binding] 1045856011293 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1045856011294 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1045856011295 Peptidase family M23; Region: Peptidase_M23; pfam01551 1045856011296 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 1045856011297 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1045856011298 S-adenosylmethionine binding site [chemical binding]; other site 1045856011299 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 1045856011300 tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984 1045856011301 Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575 1045856011302 Permutation of conserved domain; other site 1045856011303 active site 1045856011304 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 1045856011305 homotrimer interaction site [polypeptide binding]; other site 1045856011306 zinc binding site [ion binding]; other site 1045856011307 CDP-binding sites; other site 1045856011308 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1045856011309 substrate binding site; other site 1045856011310 dimer interface; other site 1045856011311 cell division protein FtsB; Reviewed; Region: ftsB; PRK00888 1045856011312 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 1045856011313 Protein of unknown function (DUF3561); Region: DUF3561; pfam12084 1045856011314 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 1045856011315 ligand-binding site [chemical binding]; other site 1045856011316 sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124 1045856011317 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 1045856011318 CysD dimerization site [polypeptide binding]; other site 1045856011319 G1 box; other site 1045856011320 putative GEF interaction site [polypeptide binding]; other site 1045856011321 GTP/Mg2+ binding site [chemical binding]; other site 1045856011322 Switch I region; other site 1045856011323 G2 box; other site 1045856011324 G3 box; other site 1045856011325 Switch II region; other site 1045856011326 G4 box; other site 1045856011327 G5 box; other site 1045856011328 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 1045856011329 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 1045856011330 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 1045856011331 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1045856011332 Active Sites [active] 1045856011333 siroheme synthase; Provisional; Region: cysG; PRK10637 1045856011334 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 1045856011335 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 1045856011336 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1045856011337 active site 1045856011338 SAM binding site [chemical binding]; other site 1045856011339 homodimer interface [polypeptide binding]; other site 1045856011340 alkaline phosphatase isozyme conversion aminopeptidase; Provisional; Region: PRK10199 1045856011341 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 1045856011342 metal binding site [ion binding]; metal-binding site 1045856011343 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 1045856011344 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1045856011345 Active Sites [active] 1045856011346 sulfite reductase subunit beta; Provisional; Region: PRK13504 1045856011347 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1045856011348 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1045856011349 sulfite reductase subunit alpha; Provisional; Region: cysJ; PRK10953 1045856011350 Flavodoxin; Region: Flavodoxin_1; pfam00258 1045856011351 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 1045856011352 FAD binding pocket [chemical binding]; other site 1045856011353 FAD binding motif [chemical binding]; other site 1045856011354 catalytic residues [active] 1045856011355 NAD binding pocket [chemical binding]; other site 1045856011356 phosphate binding motif [ion binding]; other site 1045856011357 beta-alpha-beta structure motif; other site 1045856011358 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 1045856011359 active site 1045856011360 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 1045856011361 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 1045856011362 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 1045856011363 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 1045856011364 putative active site cavity [active] 1045856011365 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 1045856011366 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1045856011367 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1045856011368 active site turn [active] 1045856011369 phosphorylation site [posttranslational modification] 1045856011370 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1045856011371 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1045856011372 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1045856011373 putative active site [active] 1045856011374 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1045856011375 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 1045856011376 NAD(P) binding site [chemical binding]; other site 1045856011377 active site 1045856011378 enolase; Provisional; Region: eno; PRK00077 1045856011379 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1045856011380 dimer interface [polypeptide binding]; other site 1045856011381 metal binding site [ion binding]; metal-binding site 1045856011382 substrate binding pocket [chemical binding]; other site 1045856011383 CTP synthetase; Validated; Region: pyrG; PRK05380 1045856011384 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 1045856011385 Catalytic site [active] 1045856011386 active site 1045856011387 UTP binding site [chemical binding]; other site 1045856011388 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 1045856011389 active site 1045856011390 putative oxyanion hole; other site 1045856011391 catalytic triad [active] 1045856011392 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 1045856011393 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 1045856011394 homodimer interface [polypeptide binding]; other site 1045856011395 metal binding site [ion binding]; metal-binding site 1045856011396 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 1045856011397 homodimer interface [polypeptide binding]; other site 1045856011398 active site 1045856011399 putative chemical substrate binding site [chemical binding]; other site 1045856011400 metal binding site [ion binding]; metal-binding site 1045856011401 (p)ppGpp synthetase I/GTP pyrophosphokinase; Provisional; Region: relA; PRK10872 1045856011402 HD domain; Region: HD_4; pfam13328 1045856011403 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1045856011404 synthetase active site [active] 1045856011405 NTP binding site [chemical binding]; other site 1045856011406 metal binding site [ion binding]; metal-binding site 1045856011407 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1045856011408 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1045856011409 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 1045856011410 TRAM domain; Region: TRAM; pfam01938 1045856011411 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1045856011412 S-adenosylmethionine binding site [chemical binding]; other site 1045856011413 hybrid sensory histidine kinase BarA; Provisional; Region: PRK11107 1045856011414 Uncharacterized signal transduction histidine kinase domain (DUF2222); Region: DUF2222; pfam09984 1045856011415 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1045856011416 dimerization interface [polypeptide binding]; other site 1045856011417 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1045856011418 dimer interface [polypeptide binding]; other site 1045856011419 phosphorylation site [posttranslational modification] 1045856011420 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1045856011421 ATP binding site [chemical binding]; other site 1045856011422 Mg2+ binding site [ion binding]; other site 1045856011423 G-X-G motif; other site 1045856011424 Uncharacterized domain of BarA-like signal transduction histidine kinases [Signal transduction mechanisms]; Region: COG4999 1045856011425 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1045856011426 active site 1045856011427 phosphorylation site [posttranslational modification] 1045856011428 intermolecular recognition site; other site 1045856011429 dimerization interface [polypeptide binding]; other site 1045856011430 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1045856011431 putative binding surface; other site 1045856011432 active site 1045856011433 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 1045856011434 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 1045856011435 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 1045856011436 active site 1045856011437 tetramer interface [polypeptide binding]; other site 1045856011438 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 1045856011439 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 1045856011440 active site 1045856011441 tetramer interface [polypeptide binding]; other site 1045856011442 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1045856011443 D-galactonate transporter; Region: 2A0114; TIGR00893 1045856011444 putative substrate translocation pore; other site 1045856011445 flavodoxin; Provisional; Region: PRK08105 1045856011446 tRNA pseudouridine isomerase C; Region: PseudoU_synth_TruC; cd02563 1045856011447 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1045856011448 probable active site [active] 1045856011449 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3098 1045856011450 SecY interacting protein Syd; Provisional; Region: PRK04968 1045856011451 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904 1045856011452 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 1045856011453 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 1045856011454 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 1045856011455 Domain of unknown function (DUF3412); Region: DUF3412; pfam11892 1045856011456 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 1045856011457 serine transporter; Region: stp; TIGR00814 1045856011458 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 1045856011459 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1045856011460 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 1045856011461 flap endonuclease-like protein; Provisional; Region: PRK09482 1045856011462 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1045856011463 active site 1045856011464 metal binding site 1 [ion binding]; metal-binding site 1045856011465 putative 5' ssDNA interaction site; other site 1045856011466 metal binding site 3; metal-binding site 1045856011467 metal binding site 2 [ion binding]; metal-binding site 1045856011468 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1045856011469 putative DNA binding site [nucleotide binding]; other site 1045856011470 putative metal binding site [ion binding]; other site 1045856011471 putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760 1045856011472 FtsJ-like methyltransferase; Region: FtsJ; cl17430 1045856011473 hypothetical protein; Provisional; Region: PRK10873 1045856011474 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1045856011475 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1045856011476 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 1045856011477 dimerization interface [polypeptide binding]; other site 1045856011478 substrate binding pocket [chemical binding]; other site 1045856011479 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 1045856011480 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1045856011481 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1045856011482 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1045856011483 catalytic residue [active] 1045856011484 Fe-S metabolism associated domain; Region: SufE; cl00951 1045856011485 sulfur acceptor protein CsdL; Provisional; Region: PRK15116 1045856011486 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 1045856011487 putative ATP binding site [chemical binding]; other site 1045856011488 putative substrate interface [chemical binding]; other site 1045856011489 murein transglycosylase A; Provisional; Region: mltA; PRK11162 1045856011490 MltA specific insert domain; Region: MltA; smart00925 1045856011491 3D domain; Region: 3D; pfam06725 1045856011492 N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431 1045856011493 AMIN domain; Region: AMIN; pfam11741 1045856011494 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1045856011495 active site 1045856011496 metal binding site [ion binding]; metal-binding site 1045856011497 N-acetylglutamate synthase; Validated; Region: PRK05279 1045856011498 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 1045856011499 putative feedback inhibition sensing region; other site 1045856011500 putative nucleotide binding site [chemical binding]; other site 1045856011501 putative substrate binding site [chemical binding]; other site 1045856011502 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1045856011503 Coenzyme A binding pocket [chemical binding]; other site 1045856011504 exonuclease V subunit alpha; Provisional; Region: recD; PRK10875 1045856011505 AAA domain; Region: AAA_30; pfam13604 1045856011506 Family description; Region: UvrD_C_2; pfam13538 1045856011507 exonuclease V subunit beta; Provisional; Region: recB; PRK10876 1045856011508 protease3; Provisional; Region: PRK15101 1045856011509 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1045856011510 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1045856011511 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1045856011512 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 1045856011513 Exonuclease V gamma subunit [DNA replication, recombination, and repair]; Region: RecC; COG1330 1045856011514 hypothetical protein; Provisional; Region: PRK10332 1045856011515 Prepilin peptidase dependent protein C term (DUF3728); Region: DUF3728; pfam12528 1045856011516 Protein of unknown function (DUF2509); Region: DUF2509; cl11672 1045856011517 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 1045856011518 hypothetical protein; Provisional; Region: PRK10506 1045856011519 thymidylate synthase; Reviewed; Region: thyA; PRK01827 1045856011520 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1045856011521 dimerization interface [polypeptide binding]; other site 1045856011522 active site 1045856011523 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 1045856011524 fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain; Provisional; Region: PRK11061 1045856011525 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1045856011526 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1045856011527 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1045856011528 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1045856011529 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 1045856011530 putative active site [active] 1045856011531 Ap4A binding site [chemical binding]; other site 1045856011532 nudix motif; other site 1045856011533 putative metal binding site [ion binding]; other site 1045856011534 MutH is a 28kD endonuclease involved in methyl-directed DNA mismatch repair in gram negative bacteria. MutH is both sequence-specific and methylation-specific, introducing a nick in the unmethylated strand of a hemi-methylated d(GATC) DNA duplex. MutH...; Region: MutH_Sau3AI; cd00583 1045856011535 putative DNA-binding cleft [nucleotide binding]; other site 1045856011536 putative DNA clevage site; other site 1045856011537 molecular lever; other site 1045856011538 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 1045856011539 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1045856011540 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1045856011541 active site 1045856011542 catalytic tetrad [active] 1045856011543 lysophospholipid transporter LplT; Provisional; Region: PRK11195 1045856011544 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1045856011545 putative substrate translocation pore; other site 1045856011546 bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase; Validated; Region: PRK08043 1045856011547 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1045856011548 putative acyl-acceptor binding pocket; other site 1045856011549 C-terminal domain of the acyl-acyl carrier protein synthetase (also called 2-acylglycerophosphoethanolamine acyltransferase, Aas); Region: AAS_C; cd05909 1045856011550 acyl-activating enzyme (AAE) consensus motif; other site 1045856011551 putative AMP binding site [chemical binding]; other site 1045856011552 DNA-binding transcriptional regulator GalR; Provisional; Region: PRK10727 1045856011553 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1045856011554 DNA binding site [nucleotide binding] 1045856011555 domain linker motif; other site 1045856011556 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 1045856011557 dimerization interface (closed form) [polypeptide binding]; other site 1045856011558 ligand binding site [chemical binding]; other site 1045856011559 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1045856011560 Coenzyme A binding pocket [chemical binding]; other site 1045856011561 DNA-binding transcriptional repressor UxuR; Provisional; Region: PRK10225 1045856011562 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1045856011563 DNA-binding site [nucleotide binding]; DNA binding site 1045856011564 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1045856011565 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 1045856011566 beta-galactosidase; Region: BGL; TIGR03356 1045856011567 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1045856011568 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 1045856011569 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1045856011570 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1045856011571 DNA binding site [nucleotide binding] 1045856011572 domain linker motif; other site 1045856011573 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 1045856011574 dimerization interface (closed form) [polypeptide binding]; other site 1045856011575 ligand binding site [chemical binding]; other site 1045856011576 diaminopimelate decarboxylase; Provisional; Region: PRK11165 1045856011577 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1045856011578 active site 1045856011579 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1045856011580 substrate binding site [chemical binding]; other site 1045856011581 catalytic residues [active] 1045856011582 dimer interface [polypeptide binding]; other site 1045856011583 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 1045856011584 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1045856011585 The C-terminal substrate binding domain of LysR, transcriptional regulator for lysine biosynthesis, contains the type 2 periplasmic binding fold; Region: PBP2_LysR; cd08456 1045856011586 putative dimerization interface [polypeptide binding]; other site 1045856011587 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 1045856011588 aspartate racemase; Region: asp_race; TIGR00035 1045856011589 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 1045856011590 LPS O-antigen length regulator; Provisional; Region: PRK10381 1045856011591 Chain length determinant protein; Region: Wzz; pfam02706 1045856011592 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1045856011593 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1045856011594 dimer interface [polypeptide binding]; other site 1045856011595 conserved gate region; other site 1045856011596 putative PBP binding loops; other site 1045856011597 ABC-ATPase subunit interface; other site 1045856011598 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1045856011599 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1045856011600 dimer interface [polypeptide binding]; other site 1045856011601 conserved gate region; other site 1045856011602 putative PBP binding loops; other site 1045856011603 ABC-ATPase subunit interface; other site 1045856011604 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1045856011605 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1045856011606 Walker A/P-loop; other site 1045856011607 ATP binding site [chemical binding]; other site 1045856011608 Q-loop/lid; other site 1045856011609 ABC transporter signature motif; other site 1045856011610 Walker B; other site 1045856011611 D-loop; other site 1045856011612 H-loop/switch region; other site 1045856011613 TOBE domain; Region: TOBE; pfam03459 1045856011614 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1045856011615 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1045856011616 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 1045856011617 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1045856011618 putative substrate translocation pore; other site 1045856011619 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1045856011620 2-deoxy-D-gluconate 3-dehydrogenase; Validated; Region: PRK08993 1045856011621 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 1045856011622 NADP binding site [chemical binding]; other site 1045856011623 homodimer interface [polypeptide binding]; other site 1045856011624 active site 1045856011625 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 1045856011626 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 1045856011627 Oligogalacturonate-specific porin protein (KdgM); Region: KdgM; cl11629 1045856011628 putative acyltransferase; Provisional; Region: PRK05790 1045856011629 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1045856011630 dimer interface [polypeptide binding]; other site 1045856011631 active site 1045856011632 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1045856011633 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1045856011634 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1045856011635 dimerization interface [polypeptide binding]; other site 1045856011636 Predicted membrane protein [Function unknown]; Region: COG4125 1045856011637 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 1045856011638 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 1045856011639 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 1045856011640 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 1045856011641 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1045856011642 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1045856011643 putative DNA binding site [nucleotide binding]; other site 1045856011644 putative Zn2+ binding site [ion binding]; other site 1045856011645 AsnC family; Region: AsnC_trans_reg; pfam01037 1045856011646 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1045856011647 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1045856011648 Coenzyme A binding pocket [chemical binding]; other site 1045856011649 Uncharacterized conserved protein [Function unknown]; Region: COG3592 1045856011650 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 1045856011651 PAS domain; Region: PAS; smart00091 1045856011652 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1045856011653 ATP binding site [chemical binding]; other site 1045856011654 Mg2+ binding site [ion binding]; other site 1045856011655 G-X-G motif; other site 1045856011656 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 1045856011657 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1045856011658 active site 1045856011659 phosphorylation site [posttranslational modification] 1045856011660 intermolecular recognition site; other site 1045856011661 dimerization interface [polypeptide binding]; other site 1045856011662 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 1045856011663 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1045856011664 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1045856011665 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 1045856011666 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1045856011667 dimer interface [polypeptide binding]; other site 1045856011668 conserved gate region; other site 1045856011669 ABC-ATPase subunit interface; other site 1045856011670 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1045856011671 dimer interface [polypeptide binding]; other site 1045856011672 conserved gate region; other site 1045856011673 putative PBP binding loops; other site 1045856011674 ABC-ATPase subunit interface; other site 1045856011675 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1045856011676 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 1045856011677 Walker A/P-loop; other site 1045856011678 ATP binding site [chemical binding]; other site 1045856011679 Q-loop/lid; other site 1045856011680 ABC transporter signature motif; other site 1045856011681 Walker B; other site 1045856011682 D-loop; other site 1045856011683 H-loop/switch region; other site 1045856011684 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 1045856011685 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 1045856011686 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 1045856011687 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 1045856011688 beta-galactosidase; Region: BGL; TIGR03356 1045856011689 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 1045856011690 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 1045856011691 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1045856011692 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 1045856011693 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 1045856011694 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 1045856011695 active site 1045856011696 P-loop; other site 1045856011697 phosphorylation site [posttranslational modification] 1045856011698 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 1045856011699 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1045856011700 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 1045856011701 methionine cluster; other site 1045856011702 active site 1045856011703 phosphorylation site [posttranslational modification] 1045856011704 metal binding site [ion binding]; metal-binding site 1045856011705 fructokinase; Reviewed; Region: PRK09557 1045856011706 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1045856011707 nucleotide binding site [chemical binding]; other site 1045856011708 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1045856011709 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1045856011710 DNA binding site [nucleotide binding] 1045856011711 domain linker motif; other site 1045856011712 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1045856011713 ligand binding site [chemical binding]; other site 1045856011714 dimerization interface [polypeptide binding]; other site 1045856011715 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1045856011716 Peptidase family M23; Region: Peptidase_M23; pfam01551 1045856011717 Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443 1045856011718 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 1045856011719 active site 1045856011720 metal binding site [ion binding]; metal-binding site 1045856011721 nudix motif; other site 1045856011722 lysyl-tRNA synthetase; Reviewed; Region: PRK12445 1045856011723 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1045856011724 dimer interface [polypeptide binding]; other site 1045856011725 putative anticodon binding site; other site 1045856011726 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 1045856011727 motif 1; other site 1045856011728 active site 1045856011729 motif 2; other site 1045856011730 motif 3; other site 1045856011731 peptide chain release factor 2; Provisional; Region: PRK08787 1045856011732 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1045856011733 RF-1 domain; Region: RF-1; pfam00472 1045856011734 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 1045856011735 DHH family; Region: DHH; pfam01368 1045856011736 DHHA1 domain; Region: DHHA1; pfam02272 1045856011737 protein disulfide isomerase II DsbC; Provisional; Region: PRK10877 1045856011738 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 1045856011739 dimerization domain [polypeptide binding]; other site 1045856011740 dimer interface [polypeptide binding]; other site 1045856011741 catalytic residues [active] 1045856011742 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 1045856011743 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 1045856011744 active site 1045856011745 Int/Topo IB signature motif; other site 1045856011746 flavodoxin FldB; Provisional; Region: PRK12359 1045856011747 Protein of unknown function (DUF1434); Region: DUF1434; pfam07254 1045856011748 hypothetical protein; Provisional; Region: PRK10878 1045856011749 putative global regulator; Reviewed; Region: PRK09559 1045856011750 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 1045856011751 hemolysin; Provisional; Region: PRK15087 1045856011752 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 1045856011753 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1045856011754 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1045856011755 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1045856011756 putative active site [active] 1045856011757 6-phospho-beta-glucosidase BglA; Provisional; Region: PRK15014 1045856011758 beta-galactosidase; Region: BGL; TIGR03356 1045856011759 putative NAD(P)-binding oxidoreductase; Provisional; Region: PRK09730 1045856011760 classical (c) SDRs; Region: SDR_c; cd05233 1045856011761 NAD(P) binding site [chemical binding]; other site 1045856011762 active site 1045856011763 glycine dehydrogenase; Provisional; Region: PRK05367 1045856011764 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1045856011765 tetramer interface [polypeptide binding]; other site 1045856011766 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1045856011767 catalytic residue [active] 1045856011768 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1045856011769 tetramer interface [polypeptide binding]; other site 1045856011770 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1045856011771 catalytic residue [active] 1045856011772 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1045856011773 lipoyl attachment site [posttranslational modification]; other site 1045856011774 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 1045856011775 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1045856011776 oxidoreductase; Provisional; Region: PRK08013 1045856011777 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 1045856011778 2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK05732 1045856011779 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 1045856011780 proline aminopeptidase P II; Provisional; Region: PRK10879 1045856011781 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 1045856011782 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 1045856011783 active site 1045856011784 hypothetical protein; Reviewed; Region: PRK01736 1045856011785 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 1045856011786 5-formyltetrahydrofolate cyclo-ligase family protein; Provisional; Region: PRK10333 1045856011787 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 1045856011788 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 1045856011789 ligand binding site [chemical binding]; other site 1045856011790 NAD binding site [chemical binding]; other site 1045856011791 tetramer interface [polypeptide binding]; other site 1045856011792 catalytic site [active] 1045856011793 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 1045856011794 L-serine binding site [chemical binding]; other site 1045856011795 ACT domain interface; other site 1045856011796 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 1045856011797 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1045856011798 active site 1045856011799 dimer interface [polypeptide binding]; other site 1045856011800 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 1045856011801 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1045856011802 The C-terminal substrate binding domain of LysR-type transcriptional regulator, ArgP (IciA), for arginine exporter (ArgO); contains the type 2 periplasmic binding fold; Region: PBP2_IciA_ArgP; cd08428 1045856011803 putative dimerization interface [polypeptide binding]; other site 1045856011804 oxidative stress defense protein; Provisional; Region: PRK11087 1045856011805 Uncharacterized conserved protein [Function unknown]; Region: COG2968 1045856011806 arginine exporter protein; Provisional; Region: PRK09304 1045856011807 mechanosensitive channel MscS; Provisional; Region: PRK10334 1045856011808 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1045856011809 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1045856011810 Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946 1045856011811 active site 1045856011812 intersubunit interface [polypeptide binding]; other site 1045856011813 zinc binding site [ion binding]; other site 1045856011814 Na+ binding site [ion binding]; other site 1045856011815 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 1045856011816 Phosphoglycerate kinase; Region: PGK; pfam00162 1045856011817 substrate binding site [chemical binding]; other site 1045856011818 hinge regions; other site 1045856011819 ADP binding site [chemical binding]; other site 1045856011820 catalytic site [active] 1045856011821 erythrose 4-phosphate dehydrogenase; Provisional; Region: PRK13535 1045856011822 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1045856011823 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1045856011824 transketolase; Reviewed; Region: PRK12753 1045856011825 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1045856011826 TPP-binding site [chemical binding]; other site 1045856011827 dimer interface [polypeptide binding]; other site 1045856011828 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1045856011829 PYR/PP interface [polypeptide binding]; other site 1045856011830 dimer interface [polypeptide binding]; other site 1045856011831 TPP binding site [chemical binding]; other site 1045856011832 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1045856011833 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 1045856011834 outer membrane porin, OprD family; Region: OprD; pfam03573 1045856011835 hypothetical protein; Provisional; Region: PRK07064 1045856011836 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1045856011837 PYR/PP interface [polypeptide binding]; other site 1045856011838 dimer interface [polypeptide binding]; other site 1045856011839 TPP binding site [chemical binding]; other site 1045856011840 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1045856011841 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 1045856011842 TPP-binding site [chemical binding]; other site 1045856011843 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1045856011844 Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114 1045856011845 NAD(P) binding site [chemical binding]; other site 1045856011846 catalytic residues [active] 1045856011847 L-aspartate dehydrogenase; Provisional; Region: PRK13303 1045856011848 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1045856011849 Domain of unknown function DUF108; Region: DUF108; pfam01958 1045856011850 short chain dehydrogenase; Provisional; Region: PRK07062 1045856011851 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1045856011852 NAD(P) binding site [chemical binding]; other site 1045856011853 active site 1045856011854 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1045856011855 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 1045856011856 nucleophilic elbow; other site 1045856011857 catalytic triad; other site 1045856011858 Cupin domain; Region: Cupin_2; pfam07883 1045856011859 D-galactonate transporter; Region: 2A0114; TIGR00893 1045856011860 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1045856011861 putative substrate translocation pore; other site 1045856011862 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 1045856011863 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1045856011864 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1045856011865 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1045856011866 active site 1045856011867 metal binding site [ion binding]; metal-binding site 1045856011868 C-terminal domain of Burkholderia sp. NF100 MhqB and similar proteins; MhqB is a type I extradiol dioxygenase involved in the catabolism of methylhydroquinone, an intermediate in the degradation of fenitrothion; Region: MhqB_like_C; cd08360 1045856011869 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1045856011870 putative active site [active] 1045856011871 putative metal binding site [ion binding]; other site 1045856011872 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1045856011873 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1045856011874 Bacterial transcriptional regulator; Region: IclR; pfam01614 1045856011875 short chain dehydrogenase; Provisional; Region: PRK12939 1045856011876 classical (c) SDRs; Region: SDR_c; cd05233 1045856011877 NAD(P) binding site [chemical binding]; other site 1045856011878 active site 1045856011879 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1045856011880 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 1045856011881 [2Fe-2S] cluster binding site [ion binding]; other site 1045856011882 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1045856011883 hydrophobic ligand binding site; other site 1045856011884 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 1045856011885 [2Fe-2S] cluster binding site [ion binding]; other site 1045856011886 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1045856011887 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1045856011888 putative substrate translocation pore; other site 1045856011889 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 1045856011890 agmatinase; Region: agmatinase; TIGR01230 1045856011891 oligomer interface [polypeptide binding]; other site 1045856011892 putative active site [active] 1045856011893 Mn binding site [ion binding]; other site 1045856011894 Arginine decarboxylase (spermidine biosynthesis) [Amino acid transport and metabolism]; Region: SpeA; COG1166 1045856011895 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 1045856011896 dimer interface [polypeptide binding]; other site 1045856011897 active site 1045856011898 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1045856011899 catalytic residues [active] 1045856011900 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 1045856011901 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1045856011902 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1045856011903 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1045856011904 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1045856011905 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 1045856011906 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1045856011907 putative substrate translocation pore; other site 1045856011908 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1045856011909 hypothetical protein; Provisional; Region: PRK04860 1045856011910 Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091 1045856011911 DNA-specific endonuclease I; Provisional; Region: PRK15137 1045856011912 Endonuclease I [DNA replication, recombination, and repair]; Region: EndA; COG2356 1045856011913 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 1045856011914 RNA methyltransferase, RsmE family; Region: TIGR00046 1045856011915 glutathione synthetase; Provisional; Region: PRK05246 1045856011916 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 1045856011917 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 1045856011918 hypothetical protein; Validated; Region: PRK00228 1045856011919 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 1045856011920 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 1045856011921 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 1045856011922 Walker A motif; other site 1045856011923 ATP binding site [chemical binding]; other site 1045856011924 Walker B motif; other site 1045856011925 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 1045856011926 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1045856011927 catalytic residue [active] 1045856011928 YGGT family; Region: YGGT; pfam02325 1045856011929 Predicted integral membrane protein [Function unknown]; Region: COG0762 1045856011930 hypothetical protein; Validated; Region: PRK05090 1045856011931 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1045856011932 active site 1045856011933 dimerization interface [polypeptide binding]; other site 1045856011934 HemN family oxidoreductase; Provisional; Region: PRK05660 1045856011935 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1045856011936 FeS/SAM binding site; other site 1045856011937 HemN C-terminal domain; Region: HemN_C; pfam06969 1045856011938 Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038 1045856011939 putative active site [active] 1045856011940 hypothetical protein; Provisional; Region: PRK10626 1045856011941 Protein of unknown function (DUF2884); Region: DUF2884; pfam11101 1045856011942 hypothetical protein; Provisional; Region: PRK11702 1045856011943 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 1045856011944 adenine DNA glycosylase; Provisional; Region: PRK10880 1045856011945 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1045856011946 minor groove reading motif; other site 1045856011947 helix-hairpin-helix signature motif; other site 1045856011948 substrate binding pocket [chemical binding]; other site 1045856011949 active site 1045856011950 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 1045856011951 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 1045856011952 DNA binding and oxoG recognition site [nucleotide binding] 1045856011953 oxidative damage protection protein; Provisional; Region: PRK05408 1045856011954 murein transglycosylase C; Provisional; Region: mltC; PRK11671 1045856011955 Domain of unknown function (DUF3393); Region: DUF3393; pfam11873 1045856011956 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1045856011957 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1045856011958 catalytic residue [active] 1045856011959 nucleoside transporter; Region: 2A0110; TIGR00889 1045856011960 ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; cl00768 1045856011961 Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase; Region: CitX; pfam03802 1045856011962 Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051 1045856011963 Coenzyme A transferase; Region: CoA_trans; cl17247 1045856011964 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 1045856011965 citrate lyase subunit gamma; Provisional; Region: PRK13253 1045856011966 Citrate lyase synthetase [Energy production and conversion]; Region: CitC; COG3053 1045856011967 Citrate lyase ligase; Region: Citrate_lyase_ligase; cd02169 1045856011968 putative active site [active] 1045856011969 (T/H)XGH motif; other site 1045856011970 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1045856011971 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1045856011972 2-hydroxycarboxylate transporter family; Region: 2HCT; pfam03390 1045856011973 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 1045856011974 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1045856011975 putative active site [active] 1045856011976 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1045856011977 ATP binding site [chemical binding]; other site 1045856011978 Mg2+ binding site [ion binding]; other site 1045856011979 G-X-G motif; other site 1045856011980 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 1045856011981 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1045856011982 active site 1045856011983 phosphorylation site [posttranslational modification] 1045856011984 intermolecular recognition site; other site 1045856011985 dimerization interface [polypeptide binding]; other site 1045856011986 Transcriptional regulator; Region: CitT; pfam12431 1045856011987 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1045856011988 ornithine decarboxylase; Provisional; Region: PRK13578 1045856011989 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 1045856011990 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 1045856011991 homodimer interface [polypeptide binding]; other site 1045856011992 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1045856011993 catalytic residue [active] 1045856011994 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1045856011995 Protein of unknown function (DUF554); Region: DUF554; pfam04474 1045856011996 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 1045856011997 DNA binding residues [nucleotide binding] 1045856011998 dimerization interface [polypeptide binding]; other site 1045856011999 outer membrane protein PgaA; Provisional; Region: pgaA; PRK10049 1045856012000 outer membrane N-deacetylase; Provisional; Region: pgaB; PRK14582 1045856012001 N-terminal putative catalytic polysaccharide deacetylase domain of bacterial poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase PgaB, and similar proteins; Region: CE4_PgaB_5s; cd10964 1045856012002 putative active site [active] 1045856012003 putative metal binding site [ion binding]; other site 1045856012004 N-glycosyltransferase; Provisional; Region: PRK11204 1045856012005 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 1045856012006 DXD motif; other site 1045856012007 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 1045856012008 PgaD-like protein; Region: PgaD; cl14676 1045856012009 bifunctional glutathionylspermidine amidase/glutathionylspermidine synthetase; Provisional; Region: PRK10507 1045856012010 CHAP domain; Region: CHAP; pfam05257 1045856012011 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 1045856012012 putative S-transferase; Provisional; Region: PRK11752 1045856012013 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 1045856012014 C-terminal domain interface [polypeptide binding]; other site 1045856012015 GSH binding site (G-site) [chemical binding]; other site 1045856012016 dimer interface [polypeptide binding]; other site 1045856012017 C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292 1045856012018 dimer interface [polypeptide binding]; other site 1045856012019 N-terminal domain interface [polypeptide binding]; other site 1045856012020 active site 1045856012021 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1045856012022 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1045856012023 dimer interface [polypeptide binding]; other site 1045856012024 putative CheW interface [polypeptide binding]; other site 1045856012025 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1045856012026 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1045856012027 active site 1045856012028 catalytic tetrad [active] 1045856012029 hypothetical protein; Provisional; Region: PRK05208 1045856012030 biopolymer transport protein ExbD; Provisional; Region: PRK11267 1045856012031 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1045856012032 biopolymer transport protein ExbB; Provisional; Region: PRK10414 1045856012033 cystathionine beta-lyase; Provisional; Region: PRK08114 1045856012034 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1045856012035 homodimer interface [polypeptide binding]; other site 1045856012036 substrate-cofactor binding pocket; other site 1045856012037 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1045856012038 catalytic residue [active] 1045856012039 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1045856012040 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1045856012041 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 1045856012042 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1045856012043 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1045856012044 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1045856012045 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 1045856012046 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 1045856012047 dimer interface [polypeptide binding]; other site 1045856012048 active site 1045856012049 metal binding site [ion binding]; metal-binding site 1045856012050 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1045856012051 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1045856012052 active site 1045856012053 catalytic tetrad [active] 1045856012054 hypothetical protein; Provisional; Region: PRK01254 1045856012055 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 1045856012056 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 1045856012057 Cation transport protein; Region: TrkH; cl17365 1045856012058 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 1045856012059 FtsI repressor; Provisional; Region: PRK10883 1045856012060 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1045856012061 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1045856012062 1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional; Region: PRK15018 1045856012063 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1045856012064 putative acyl-acceptor binding pocket; other site 1045856012065 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 1045856012066 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1045856012067 CAP-like domain; other site 1045856012068 active site 1045856012069 primary dimer interface [polypeptide binding]; other site 1045856012070 Periplasmic protein with OB-fold [Function unknown]; Region: COG3111 1045856012071 DNA-binding transcriptional regulator QseB; Provisional; Region: PRK10336 1045856012072 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1045856012073 active site 1045856012074 phosphorylation site [posttranslational modification] 1045856012075 intermolecular recognition site; other site 1045856012076 dimerization interface [polypeptide binding]; other site 1045856012077 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1045856012078 DNA binding site [nucleotide binding] 1045856012079 sensor protein QseC; Provisional; Region: PRK10337 1045856012080 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 1045856012081 dimer interface [polypeptide binding]; other site 1045856012082 phosphorylation site [posttranslational modification] 1045856012083 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1045856012084 ATP binding site [chemical binding]; other site 1045856012085 Mg2+ binding site [ion binding]; other site 1045856012086 G-X-G motif; other site 1045856012087 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 1045856012088 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1045856012089 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 1045856012090 galactoside permease; Reviewed; Region: lacY; PRK09528 1045856012091 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1045856012092 putative substrate translocation pore; other site 1045856012093 Uncharacterized protein conserved in bacteria (DUF2264); Region: DUF2264; pfam10022 1045856012094 Cupin domain; Region: Cupin_2; pfam07883 1045856012095 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1045856012096 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1045856012097 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1045856012098 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1045856012099 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1045856012100 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1045856012101 putative active site [active] 1045856012102 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1045856012103 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1045856012104 siderophore binding site; other site 1045856012105 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1045856012106 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1045856012107 ABC-ATPase subunit interface; other site 1045856012108 dimer interface [polypeptide binding]; other site 1045856012109 putative PBP binding regions; other site 1045856012110 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1045856012111 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1045856012112 ABC-ATPase subunit interface; other site 1045856012113 dimer interface [polypeptide binding]; other site 1045856012114 putative PBP binding regions; other site 1045856012115 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1045856012116 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1045856012117 Walker A/P-loop; other site 1045856012118 ATP binding site [chemical binding]; other site 1045856012119 Q-loop/lid; other site 1045856012120 ABC transporter signature motif; other site 1045856012121 Walker B; other site 1045856012122 D-loop; other site 1045856012123 H-loop/switch region; other site 1045856012124 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1045856012125 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1045856012126 N-terminal plug; other site 1045856012127 ligand-binding site [chemical binding]; other site 1045856012128 DNA topoisomerase IV, B subunit, proteobacterial; Region: parE_Gneg; TIGR01055 1045856012129 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1045856012130 ATP binding site [chemical binding]; other site 1045856012131 Mg2+ binding site [ion binding]; other site 1045856012132 G-X-G motif; other site 1045856012133 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1045856012134 anchoring element; other site 1045856012135 dimer interface [polypeptide binding]; other site 1045856012136 ATP binding site [chemical binding]; other site 1045856012137 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 1045856012138 active site 1045856012139 metal binding site [ion binding]; metal-binding site 1045856012140 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1045856012141 esterase YqiA; Provisional; Region: PRK11071 1045856012142 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1045856012143 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 1045856012144 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1045856012145 active site 1045856012146 metal binding site [ion binding]; metal-binding site 1045856012147 hexamer interface [polypeptide binding]; other site 1045856012148 putative dehydrogenase; Provisional; Region: PRK11039 1045856012149 ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729 1045856012150 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1045856012151 dimer interface [polypeptide binding]; other site 1045856012152 ADP-ribose binding site [chemical binding]; other site 1045856012153 active site 1045856012154 nudix motif; other site 1045856012155 metal binding site [ion binding]; metal-binding site 1045856012156 outer membrane channel protein; Reviewed; Region: tolC; PRK09465 1045856012157 hypothetical protein; Provisional; Region: PRK11653 1045856012158 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 1045856012159 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 1045856012160 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 1045856012161 putative active site [active] 1045856012162 metal binding site [ion binding]; metal-binding site 1045856012163 zinc transporter ZupT; Provisional; Region: PRK04201 1045856012164 ZIP Zinc transporter; Region: Zip; pfam02535 1045856012165 3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353 1045856012166 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 1045856012167 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2960 1045856012168 bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316 1045856012169 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 1045856012170 putative ribose interaction site [chemical binding]; other site 1045856012171 putative ADP binding site [chemical binding]; other site 1045856012172 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 1045856012173 active site 1045856012174 nucleotide binding site [chemical binding]; other site 1045856012175 HIGH motif; other site 1045856012176 KMSKS motif; other site 1045856012177 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 1045856012178 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1045856012179 metal binding triad; other site 1045856012180 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1045856012181 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1045856012182 metal binding triad; other site 1045856012183 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1045856012184 Uncharacterized conserved protein [Function unknown]; Region: COG3025 1045856012185 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 1045856012186 putative active site [active] 1045856012187 putative metal binding residues [ion binding]; other site 1045856012188 signature motif; other site 1045856012189 putative triphosphate binding site [ion binding]; other site 1045856012190 CHAD domain; Region: CHAD; pfam05235 1045856012191 SH3 domain-containing protein; Provisional; Region: PRK10884 1045856012192 Bacterial SH3 domain homologues; Region: SH3b; smart00287 1045856012193 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1045856012194 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 1045856012195 active site 1045856012196 NTP binding site [chemical binding]; other site 1045856012197 metal binding triad [ion binding]; metal-binding site 1045856012198 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1045856012199 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1045856012200 Zn2+ binding site [ion binding]; other site 1045856012201 Mg2+ binding site [ion binding]; other site 1045856012202 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 1045856012203 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 1045856012204 homooctamer interface [polypeptide binding]; other site 1045856012205 active site 1045856012206 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 1045856012207 benzoate transport; Region: 2A0115; TIGR00895 1045856012208 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1045856012209 putative substrate translocation pore; other site 1045856012210 UreD urease accessory protein; Region: UreD; cl00530 1045856012211 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 1045856012212 alpha-gamma subunit interface [polypeptide binding]; other site 1045856012213 beta-gamma subunit interface [polypeptide binding]; other site 1045856012214 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 1045856012215 gamma-beta subunit interface [polypeptide binding]; other site 1045856012216 alpha-beta subunit interface [polypeptide binding]; other site 1045856012217 urease subunit alpha; Reviewed; Region: ureC; PRK13207 1045856012218 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 1045856012219 subunit interactions [polypeptide binding]; other site 1045856012220 active site 1045856012221 flap region; other site 1045856012222 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 1045856012223 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 1045856012224 dimer interface [polypeptide binding]; other site 1045856012225 catalytic residues [active] 1045856012226 HupE / UreJ protein; Region: HupE_UreJ; pfam04955 1045856012227 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 1045856012228 UreF; Region: UreF; pfam01730 1045856012229 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1045856012230 UGMP family protein; Validated; Region: PRK09604 1045856012231 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 1045856012232 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1045856012233 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 1045856012234 DNA primase; Validated; Region: dnaG; PRK05667 1045856012235 CHC2 zinc finger; Region: zf-CHC2; pfam01807 1045856012236 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1045856012237 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1045856012238 active site 1045856012239 metal binding site [ion binding]; metal-binding site 1045856012240 interdomain interaction site; other site 1045856012241 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 1045856012242 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278 1045856012243 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 1045856012244 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 1045856012245 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1045856012246 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 1045856012247 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1045856012248 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1045856012249 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1045856012250 DNA binding residues [nucleotide binding] 1045856012251 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 1045856012252 active site 1045856012253 SUMO-1 interface [polypeptide binding]; other site 1045856012254 tail protein; Provisional; Region: D; PHA02561 1045856012255 Phage P2 GpU; Region: Phage_P2_GpU; pfam06995 1045856012256 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 1045856012257 Phage P2 GpE; Region: Phage_P2_GpE; pfam06528 1045856012258 Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109 1045856012259 Phage tail tube protein FII; Region: Phage_tube; cl01390 1045856012260 major tail sheath protein; Provisional; Region: FI; PHA02560 1045856012261 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 1045856012262 Phage tail-collar fibre protein; Region: DUF3751; pfam12571 1045856012263 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 1045856012264 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 1045856012265 Phage T4 tail fibre; Region: Phage_T4_gp36; pfam03903 1045856012266 phage tail protein, P2 protein I family; Region: tail_P2_I; TIGR01634 1045856012267 baseplate assembly protein; Provisional; Region: J; PHA02568 1045856012268 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 1045856012269 phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644 1045856012270 Phage P2 baseplate assembly protein gpV [General function prediction only]; Region: gpV; COG4540 1045856012271 P2 phage tail completion protein R (GpR); Region: P2_Phage_GpR; pfam06891 1045856012272 phage lysis regulatory protein, LysB family; Region: phage_LysB; TIGR03495 1045856012273 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 1045856012274 catalytic residues [active] 1045856012275 DinI-like family; Region: DinI; cl11630 1045856012276 Bacteriophage replication gene A protein (GPA); Region: Phage_GPA; pfam05840 1045856012277 Protein of unknown function (DUF2732); Region: DUF2732; pfam10809 1045856012278 Bacteriophage CI repressor helix-turn-helix domain; Region: Phage_CI_repr; pfam07022 1045856012279 DnaJ-domain-containing proteins 1 [Posttranslational modification, protein turnover, chaperones]; Region: DjlA; COG1076 1045856012280 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cl02542 1045856012281 HSP70 interaction site [polypeptide binding]; other site 1045856012282 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 1045856012283 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 1045856012284 FAD binding pocket [chemical binding]; other site 1045856012285 FAD binding motif [chemical binding]; other site 1045856012286 phosphate binding motif [ion binding]; other site 1045856012287 NAD binding pocket [chemical binding]; other site 1045856012288 Predicted transcriptional regulators [Transcription]; Region: COG1695 1045856012289 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1045856012290 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1045856012291 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1045856012292 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1045856012293 dimerization interface [polypeptide binding]; other site 1045856012294 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1045856012295 dimer interface [polypeptide binding]; other site 1045856012296 putative CheW interface [polypeptide binding]; other site 1045856012297 PAS fold; Region: PAS_3; pfam08447 1045856012298 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1045856012299 putative active site [active] 1045856012300 heme pocket [chemical binding]; other site 1045856012301 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1045856012302 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1045856012303 dimer interface [polypeptide binding]; other site 1045856012304 putative CheW interface [polypeptide binding]; other site 1045856012305 putrescine--2-oxoglutarate aminotransferase; Provisional; Region: PRK11522 1045856012306 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1045856012307 inhibitor-cofactor binding pocket; inhibition site 1045856012308 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1045856012309 catalytic residue [active] 1045856012310 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1045856012311 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1045856012312 non-specific DNA binding site [nucleotide binding]; other site 1045856012313 salt bridge; other site 1045856012314 sequence-specific DNA binding site [nucleotide binding]; other site 1045856012315 Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382 1045856012316 B3/4 domain; Region: B3_4; pfam03483 1045856012317 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1045856012318 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 1045856012319 inhibitor site; inhibition site 1045856012320 active site 1045856012321 dimer interface [polypeptide binding]; other site 1045856012322 catalytic residue [active] 1045856012323 autoinducer-2 (AI-2) modifying protein LsrG; Provisional; Region: PRK10486 1045856012324 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830 1045856012325 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 1045856012326 putative active site; other site 1045856012327 catalytic residue [active] 1045856012328 autoinducer 2-binding protein lsrB; Provisional; Region: PRK15408 1045856012329 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 1045856012330 ligand binding site [chemical binding]; other site 1045856012331 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1045856012332 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1045856012333 TM-ABC transporter signature motif; other site 1045856012334 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1045856012335 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1045856012336 TM-ABC transporter signature motif; other site 1045856012337 autoinducer 2 ABC transporter ATP-binding protein LsrA; Provisional; Region: PRK15439 1045856012338 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1045856012339 Walker A/P-loop; other site 1045856012340 ATP binding site [chemical binding]; other site 1045856012341 Q-loop/lid; other site 1045856012342 ABC transporter signature motif; other site 1045856012343 Walker B; other site 1045856012344 D-loop; other site 1045856012345 H-loop/switch region; other site 1045856012346 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1045856012347 transcriptional regulator LsrR; Provisional; Region: PRK15418 1045856012348 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1045856012349 autoinducer-2 (AI-2) kinase; Provisional; Region: PRK10939 1045856012350 Autoinducer-2 kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_AI-2K; cd07775 1045856012351 putative N- and C-terminal domain interface [polypeptide binding]; other site 1045856012352 putative active site [active] 1045856012353 putative MgATP binding site [chemical binding]; other site 1045856012354 catalytic site [active] 1045856012355 metal binding site [ion binding]; metal-binding site 1045856012356 putative carbohydrate binding site [chemical binding]; other site 1045856012357 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1045856012358 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 1045856012359 active site 1045856012360 FMN binding site [chemical binding]; other site 1045856012361 2,4-decadienoyl-CoA binding site; other site 1045856012362 catalytic residue [active] 1045856012363 4Fe-4S cluster binding site [ion binding]; other site 1045856012364 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 1045856012365 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1045856012366 SAM-dependent 23S ribosomal RNA mG1835 methyltransferase; Provisional; Region: PRK15001 1045856012367 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1045856012368 S-adenosylmethionine binding site [chemical binding]; other site 1045856012369 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451 1045856012370 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1045856012371 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1045856012372 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 1045856012373 serine/threonine transporter SstT; Provisional; Region: PRK13628 1045856012374 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1045856012375 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 1045856012376 galactarate dehydratase; Region: galactar-dH20; TIGR03248 1045856012377 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 1045856012378 Glucuronate isomerase; Region: UxaC; pfam02614 1045856012379 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 1045856012380 D-galactonate transporter; Region: 2A0114; TIGR00893 1045856012381 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1045856012382 putative substrate translocation pore; other site 1045856012383 DNA-binding transcriptional repressor ExuR; Provisional; Region: PRK11523 1045856012384 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1045856012385 DNA-binding site [nucleotide binding]; DNA binding site 1045856012386 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1045856012387 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1045856012388 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1045856012389 EnvZ/OmpR regulon moderator; Provisional; Region: PRK10629 1045856012390 Protein of unknown function (DUF1090); Region: DUF1090; pfam06476 1045856012391 Uncharacterized conserved protein [Function unknown]; Region: ElaB; COG4575 1045856012392 Predicted membrane protein [Function unknown]; Region: COG5393 1045856012393 YqjK-like protein; Region: YqjK; pfam13997 1045856012394 Predicted membrane protein [Function unknown]; Region: COG2259 1045856012395 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 1045856012396 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 1045856012397 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 1045856012398 putative dimer interface [polypeptide binding]; other site 1045856012399 N-terminal domain interface [polypeptide binding]; other site 1045856012400 putative substrate binding pocket (H-site) [chemical binding]; other site 1045856012401 Predicted membrane protein [Function unknown]; Region: COG3152 1045856012402 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1045856012403 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 1045856012404 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1045856012405 dimerization interface [polypeptide binding]; other site 1045856012406 Pirin-related protein [General function prediction only]; Region: COG1741 1045856012407 Pirin; Region: Pirin; pfam02678 1045856012408 L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681 1045856012409 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 1045856012410 serine transporter; Region: stp; TIGR00814 1045856012411 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 1045856012412 dimer interface [polypeptide binding]; other site 1045856012413 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 1045856012414 Pyruvate formate lyase 1; Region: PFL1; cd01678 1045856012415 coenzyme A binding site [chemical binding]; other site 1045856012416 active site 1045856012417 catalytic residues [active] 1045856012418 glycine loop; other site 1045856012419 propionate/acetate kinase; Provisional; Region: PRK12379 1045856012420 Acetate kinase [Energy production and conversion]; Region: ackA; COG0282 1045856012421 threonine/serine transporter TdcC; Provisional; Region: PRK13629 1045856012422 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 1045856012423 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 1045856012424 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1045856012425 tetramer interface [polypeptide binding]; other site 1045856012426 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1045856012427 catalytic residue [active] 1045856012428 DNA-binding transcriptional activator TdcA; Provisional; Region: PRK10341 1045856012429 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1045856012430 The C-terminal substrate binding domain of LysR-type transcriptional regulator TdcA, which is involved in the degradation of L-serine and L-threonine, contains the type 2 periplasmic binding fold; Region: PBP2_TdcA; cd08418 1045856012431 putative substrate binding pocket [chemical binding]; other site 1045856012432 putative dimerization interface [polypeptide binding]; other site 1045856012433 The Death Domain Superfamily of protein-protein interaction domains; Region: DD_superfamily; cl14633 1045856012434 Glycerate kinase family; Region: Gly_kinase; cl00841 1045856012435 tartronate semialdehyde reductase; Provisional; Region: garR; PRK11559 1045856012436 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1045856012437 alpha-dehydro-beta-deoxy-D-glucarate aldolase; Provisional; Region: PRK10558 1045856012438 galactarate dehydratase; Region: galactar-dH20; TIGR03248 1045856012439 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 1045856012440 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 1045856012441 DNA-binding transcriptional regulator AgaR; Provisional; Region: PRK09802 1045856012442 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1045856012443 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1045856012444 tagatose 6-phosphate aldolase subunit KbaZ; Provisional; Region: PRK15458 1045856012445 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 1045856012446 active site 1045856012447 phosphorylation site [posttranslational modification] 1045856012448 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 1045856012449 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 1045856012450 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 1045856012451 active pocket/dimerization site; other site 1045856012452 active site 1045856012453 phosphorylation site [posttranslational modification] 1045856012454 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 1045856012455 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 1045856012456 active site 1045856012457 dimer interface [polypeptide binding]; other site 1045856012458 putative sugar isomerase, AgaS family; Region: agaS_fam; TIGR02815 1045856012459 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1045856012460 dimer interface [polypeptide binding]; other site 1045856012461 active site 1045856012462 AgaS-like protein. AgaS contains a SIS (Sugar ISomerase) domain which is found in many phosphosugar isomerases and phosphosugar binding proteins. AgaS is a putative isomerase in Escherichia coli. It is similar to the glucosamine-6-phosphate synthases; Region: SIS_AgaS_like; cd05010 1045856012463 putative active site [active] 1045856012464 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1045856012465 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1045856012466 intersubunit interface [polypeptide binding]; other site 1045856012467 active site 1045856012468 zinc binding site [ion binding]; other site 1045856012469 Na+ binding site [ion binding]; other site 1045856012470 bifunctional PTS system maltose and glucose-specific transporter subunits IICB; Provisional; Region: PRK10110 1045856012471 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1045856012472 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1045856012473 active site turn [active] 1045856012474 phosphorylation site [posttranslational modification] 1045856012475 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 1045856012476 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1045856012477 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1045856012478 homodimer interface [polypeptide binding]; other site 1045856012479 catalytic residue [active] 1045856012480 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 1045856012481 SAM-dependent 16S ribosomal RNA C1402 ribose 2'-O-methyltransferase; Provisional; Region: PRK14994 1045856012482 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 1045856012483 putative SAM binding site [chemical binding]; other site 1045856012484 putative homodimer interface [polypeptide binding]; other site 1045856012485 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1045856012486 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 1045856012487 putative ligand binding site [chemical binding]; other site 1045856012488 hypothetical protein; Reviewed; Region: PRK12497 1045856012489 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 1045856012490 dimer interface [polypeptide binding]; other site 1045856012491 active site 1045856012492 outer membrane lipoprotein; Provisional; Region: PRK11023 1045856012493 BON domain; Region: BON; pfam04972 1045856012494 BON domain; Region: BON; pfam04972 1045856012495 Predicted permease; Region: DUF318; pfam03773 1045856012496 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 1045856012497 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1045856012498 NAD binding site [chemical binding]; other site 1045856012499 active site 1045856012500 intracellular protease, PfpI family; Region: PfpI; TIGR01382 1045856012501 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 1045856012502 proposed catalytic triad [active] 1045856012503 conserved cys residue [active] 1045856012504 hypothetical protein; Provisional; Region: PRK03467 1045856012505 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 1045856012506 GIY-YIG motif/motif A; other site 1045856012507 putative active site [active] 1045856012508 putative metal binding site [ion binding]; other site 1045856012509 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1045856012510 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1045856012511 Coenzyme A binding pocket [chemical binding]; other site 1045856012512 Putative lipid carrier protein [Lipid metabolism]; Region: COG3154 1045856012513 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1045856012514 Peptidase family U32; Region: Peptidase_U32; pfam01136 1045856012515 putative protease; Provisional; Region: PRK15447 1045856012516 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1045856012517 hypothetical protein; Provisional; Region: PRK10508 1045856012518 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1045856012519 tryptophan permease; Provisional; Region: PRK10483 1045856012520 aromatic amino acid transport protein; Region: araaP; TIGR00837 1045856012521 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 1045856012522 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1045856012523 ATP binding site [chemical binding]; other site 1045856012524 Mg++ binding site [ion binding]; other site 1045856012525 motif III; other site 1045856012526 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1045856012527 nucleotide binding region [chemical binding]; other site 1045856012528 ATP-binding site [chemical binding]; other site 1045856012529 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 1045856012530 putative RNA binding site [nucleotide binding]; other site 1045856012531 lipoprotein NlpI; Provisional; Region: PRK11189 1045856012532 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1045856012533 binding surface 1045856012534 TPR motif; other site 1045856012535 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 1045856012536 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 1045856012537 RNase E interface [polypeptide binding]; other site 1045856012538 trimer interface [polypeptide binding]; other site 1045856012539 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 1045856012540 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 1045856012541 RNase E interface [polypeptide binding]; other site 1045856012542 trimer interface [polypeptide binding]; other site 1045856012543 active site 1045856012544 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 1045856012545 putative nucleic acid binding region [nucleotide binding]; other site 1045856012546 G-X-X-G motif; other site 1045856012547 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1045856012548 RNA binding site [nucleotide binding]; other site 1045856012549 domain interface; other site 1045856012550 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 1045856012551 16S/18S rRNA binding site [nucleotide binding]; other site 1045856012552 S13e-L30e interaction site [polypeptide binding]; other site 1045856012553 25S rRNA binding site [nucleotide binding]; other site 1045856012554 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 1045856012555 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1045856012556 RNA binding site [nucleotide binding]; other site 1045856012557 active site 1045856012558 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 1045856012559 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 1045856012560 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1045856012561 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 1045856012562 translation initiation factor IF-2; Region: IF-2; TIGR00487 1045856012563 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1045856012564 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1045856012565 G1 box; other site 1045856012566 putative GEF interaction site [polypeptide binding]; other site 1045856012567 GTP/Mg2+ binding site [chemical binding]; other site 1045856012568 Switch I region; other site 1045856012569 G2 box; other site 1045856012570 G3 box; other site 1045856012571 Switch II region; other site 1045856012572 G4 box; other site 1045856012573 G5 box; other site 1045856012574 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1045856012575 Translation-initiation factor 2; Region: IF-2; pfam11987 1045856012576 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1045856012577 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 1045856012578 NusA N-terminal domain; Region: NusA_N; pfam08529 1045856012579 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1045856012580 RNA binding site [nucleotide binding]; other site 1045856012581 homodimer interface [polypeptide binding]; other site 1045856012582 NusA-like KH domain; Region: KH_5; pfam13184 1045856012583 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1045856012584 G-X-X-G motif; other site 1045856012585 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 1045856012586 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 1045856012587 ribosome maturation protein RimP; Reviewed; Region: PRK00092 1045856012588 Sm and related proteins; Region: Sm_like; cl00259 1045856012589 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 1045856012590 putative oligomer interface [polypeptide binding]; other site 1045856012591 putative RNA binding site [nucleotide binding]; other site 1045856012592 argininosuccinate synthase; Validated; Region: PRK05370 1045856012593 argininosuccinate synthase; Provisional; Region: PRK13820 1045856012594 Preprotein translocase SecG subunit; Region: SecG; pfam03840 1045856012595 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 1045856012596 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 1045856012597 active site 1045856012598 substrate binding site [chemical binding]; other site 1045856012599 metal binding site [ion binding]; metal-binding site 1045856012600 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1045856012601 dihydropteroate synthase; Region: DHPS; TIGR01496 1045856012602 substrate binding pocket [chemical binding]; other site 1045856012603 dimer interface [polypeptide binding]; other site 1045856012604 inhibitor binding site; inhibition site 1045856012605 ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733 1045856012606 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1045856012607 Walker A motif; other site 1045856012608 ATP binding site [chemical binding]; other site 1045856012609 Walker B motif; other site 1045856012610 arginine finger; other site 1045856012611 Peptidase family M41; Region: Peptidase_M41; pfam01434 1045856012612 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 1045856012613 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1045856012614 S-adenosylmethionine binding site [chemical binding]; other site 1045856012615 RNA-binding protein YhbY; Provisional; Region: PRK10343 1045856012616 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1045856012617 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1045856012618 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1045856012619 D-alanyl-D-alanine carboxypeptidase/endopeptidase; Provisional; Region: PRK11113 1045856012620 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 1045856012621 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 1045856012622 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1045856012623 active site 1045856012624 phosphorylation site [posttranslational modification] 1045856012625 intermolecular recognition site; other site 1045856012626 dimerization interface [polypeptide binding]; other site 1045856012627 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1045856012628 DNA binding site [nucleotide binding] 1045856012629 sensor protein BasS/PmrB; Provisional; Region: PRK10755 1045856012630 HAMP domain; Region: HAMP; pfam00672 1045856012631 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1045856012632 dimer interface [polypeptide binding]; other site 1045856012633 phosphorylation site [posttranslational modification] 1045856012634 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1045856012635 ATP binding site [chemical binding]; other site 1045856012636 Mg2+ binding site [ion binding]; other site 1045856012637 G-X-G motif; other site 1045856012638 GTPase CgtA; Reviewed; Region: obgE; PRK12298 1045856012639 GTP1/OBG; Region: GTP1_OBG; pfam01018 1045856012640 Obg GTPase; Region: Obg; cd01898 1045856012641 G1 box; other site 1045856012642 GTP/Mg2+ binding site [chemical binding]; other site 1045856012643 Switch I region; other site 1045856012644 G2 box; other site 1045856012645 G3 box; other site 1045856012646 Switch II region; other site 1045856012647 G4 box; other site 1045856012648 G5 box; other site 1045856012649 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1045856012650 EamA-like transporter family; Region: EamA; pfam00892 1045856012651 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 1045856012652 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1045856012653 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1045856012654 substrate binding pocket [chemical binding]; other site 1045856012655 chain length determination region; other site 1045856012656 substrate-Mg2+ binding site; other site 1045856012657 catalytic residues [active] 1045856012658 aspartate-rich region 1; other site 1045856012659 active site lid residues [active] 1045856012660 aspartate-rich region 2; other site 1045856012661 DNA-binding transcriptional regulator Nlp; Provisional; Region: PRK10344 1045856012662 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1045856012663 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1045856012664 hinge; other site 1045856012665 active site 1045856012666 BolA-like protein; Region: BolA; cl00386 1045856012667 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1045856012668 anti sigma factor interaction site; other site 1045856012669 regulatory phosphorylation site [posttranslational modification]; other site 1045856012670 ABC transporter periplasmic binding protein MlaC; Provisional; Region: PRK15117 1045856012671 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 1045856012672 mce related protein; Region: MCE; pfam02470 1045856012673 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1045856012674 conserved hypothetical integral membrane protein; Region: TIGR00056 1045856012675 putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831 1045856012676 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 1045856012677 Walker A/P-loop; other site 1045856012678 ATP binding site [chemical binding]; other site 1045856012679 Q-loop/lid; other site 1045856012680 ABC transporter signature motif; other site 1045856012681 Walker B; other site 1045856012682 D-loop; other site 1045856012683 H-loop/switch region; other site 1045856012684 putative calcium/sodium:proton antiporter; Provisional; Region: PRK10734 1045856012685 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1045856012686 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1045856012687 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 1045856012688 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 1045856012689 putative active site [active] 1045856012690 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 1045856012691 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase; Provisional; Region: PRK09484 1045856012692 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 1045856012693 lipopolysaccharide exporter periplasmic protein; Provisional; Region: PRK10893 1045856012694 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 1045856012695 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1934 1045856012696 lipopolysaccharide transport periplasmic protein LptA; Provisional; Region: PRK10894 1045856012697 lipopolysaccharide ABC transporter ATP-binding protein; Provisional; Region: PRK10895 1045856012698 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 1045856012699 Walker A/P-loop; other site 1045856012700 ATP binding site [chemical binding]; other site 1045856012701 Q-loop/lid; other site 1045856012702 ABC transporter signature motif; other site 1045856012703 Walker B; other site 1045856012704 D-loop; other site 1045856012705 H-loop/switch region; other site 1045856012706 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 1045856012707 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 1045856012708 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 1045856012709 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 1045856012710 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1045856012711 30S subunit binding site; other site 1045856012712 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1045856012713 active site 1045856012714 phosphorylation site [posttranslational modification] 1045856012715 P-loop ATPase protein family; Region: ATP_bind_2; cl15794 1045856012716 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1045856012717 dimerization domain swap beta strand [polypeptide binding]; other site 1045856012718 regulatory protein interface [polypeptide binding]; other site 1045856012719 active site 1045856012720 regulatory phosphorylation site [posttranslational modification]; other site 1045856012721 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 1045856012722 Transglycosylase; Region: Transgly; cl17702 1045856012723 isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780 1045856012724 Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133 1045856012725 conserved cys residue [active] 1045856012726 aerobic respiration control sensor protein ArcB; Provisional; Region: PRK11091 1045856012727 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1045856012728 putative active site [active] 1045856012729 heme pocket [chemical binding]; other site 1045856012730 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1045856012731 dimer interface [polypeptide binding]; other site 1045856012732 phosphorylation site [posttranslational modification] 1045856012733 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1045856012734 ATP binding site [chemical binding]; other site 1045856012735 Mg2+ binding site [ion binding]; other site 1045856012736 G-X-G motif; other site 1045856012737 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1045856012738 active site 1045856012739 phosphorylation site [posttranslational modification] 1045856012740 intermolecular recognition site; other site 1045856012741 dimerization interface [polypeptide binding]; other site 1045856012742 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1045856012743 putative binding surface; other site 1045856012744 active site 1045856012745 lipopolysaccharide ABC transporter permease; Provisional; Region: PRK15071 1045856012746 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 1045856012747 lipopolysaccharide ABC transporter permease LptF; Provisional; Region: PRK15120 1045856012748 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 1045856012749 multifunctional aminopeptidase A; Provisional; Region: PRK00913 1045856012750 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1045856012751 interface (dimer of trimers) [polypeptide binding]; other site 1045856012752 Substrate-binding/catalytic site; other site 1045856012753 Zn-binding sites [ion binding]; other site 1045856012754 DNA polymerase III subunit chi; Validated; Region: PRK05728 1045856012755 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 1045856012756 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1045856012757 HIGH motif; other site 1045856012758 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1045856012759 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1045856012760 active site 1045856012761 KMSKS motif; other site 1045856012762 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1045856012763 tRNA binding surface [nucleotide binding]; other site 1045856012764 anticodon binding site; other site 1045856012765 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 1045856012766 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1045856012767 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1045856012768 Coenzyme A binding pocket [chemical binding]; other site 1045856012769 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1045856012770 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 1045856012771 putative NAD(P) binding site [chemical binding]; other site 1045856012772 putative substrate binding site [chemical binding]; other site 1045856012773 catalytic Zn binding site [ion binding]; other site 1045856012774 structural Zn binding site [ion binding]; other site 1045856012775 dimer interface [polypeptide binding]; other site 1045856012776 dihydroxyacetone kinase, ATP-dependent; Region: dak_ATP; TIGR02361 1045856012777 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 1045856012778 DAK2 domain; Region: Dak2; pfam02734 1045856012779 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 1045856012780 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1045856012781 radical SAM protein, TIGR01212 family; Region: TIGR01212 1045856012782 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1045856012783 FeS/SAM binding site; other site 1045856012784 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 1045856012785 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 1045856012786 active site 1045856012787 dimer interface [polypeptide binding]; other site 1045856012788 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 1045856012789 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1045856012790 active site 1045856012791 FMN binding site [chemical binding]; other site 1045856012792 substrate binding site [chemical binding]; other site 1045856012793 3Fe-4S cluster binding site [ion binding]; other site 1045856012794 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 1045856012795 domain interface; other site 1045856012796 glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318 1045856012797 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1045856012798 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1045856012799 hypothetical protein; Provisional; Region: PRK15301 1045856012800 putative fimbrial outer membrane usher protein; Provisional; Region: PRK15304 1045856012801 PapC N-terminal domain; Region: PapC_N; pfam13954 1045856012802 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1045856012803 PapC C-terminal domain; Region: PapC_C; pfam13953 1045856012804 putative fimbrial chaperone protein; Provisional; Region: PRK09918 1045856012805 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1045856012806 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1045856012807 Protein of unknown function (DUF1120); Region: DUF1120; cl05856 1045856012808 ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798 1045856012809 stringent starvation protein A; Provisional; Region: sspA; PRK09481 1045856012810 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 1045856012811 C-terminal domain interface [polypeptide binding]; other site 1045856012812 putative GSH binding site (G-site) [chemical binding]; other site 1045856012813 dimer interface [polypeptide binding]; other site 1045856012814 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 1045856012815 dimer interface [polypeptide binding]; other site 1045856012816 N-terminal domain interface [polypeptide binding]; other site 1045856012817 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 1045856012818 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1045856012819 23S rRNA interface [nucleotide binding]; other site 1045856012820 L3 interface [polypeptide binding]; other site 1045856012821 Predicted ATPase [General function prediction only]; Region: COG1485 1045856012822 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3105 1045856012823 hypothetical protein; Provisional; Region: PRK11677 1045856012824 serine endoprotease; Provisional; Region: PRK10139 1045856012825 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1045856012826 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1045856012827 protein binding site [polypeptide binding]; other site 1045856012828 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1045856012829 serine endoprotease; Provisional; Region: PRK10898 1045856012830 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1045856012831 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1045856012832 malate dehydrogenase; Provisional; Region: PRK05086 1045856012833 Glyoxysomal and mitochondrial malate dehydrogenases; Region: MDH_glyoxysomal_mitochondrial; cd01337 1045856012834 NAD binding site [chemical binding]; other site 1045856012835 dimerization interface [polypeptide binding]; other site 1045856012836 Substrate binding site [chemical binding]; other site 1045856012837 arginine repressor; Provisional; Region: PRK05066 1045856012838 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1045856012839 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1045856012840 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1045856012841 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1045856012842 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it thus inhibiting its potentially lethal RNase activity inside the cell; Region: Barstar; cd05142 1045856012843 RNAase interaction site [polypeptide binding]; other site 1045856012844 succinic semialdehyde dehydrogenase; Region: PLN02278 1045856012845 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 1045856012846 tetramerization interface [polypeptide binding]; other site 1045856012847 NAD(P) binding site [chemical binding]; other site 1045856012848 catalytic residues [active] 1045856012849 p-hydroxybenzoic acid efflux subunit AaeB; Provisional; Region: PRK10631 1045856012850 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1045856012851 p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559 1045856012852 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1045856012853 HlyD family secretion protein; Region: HlyD_3; pfam13437 1045856012854 efflux system membrane protein; Provisional; Region: PRK11594 1045856012855 transcriptional regulator; Provisional; Region: PRK10632 1045856012856 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1045856012857 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1045856012858 putative effector binding pocket; other site 1045856012859 dimerization interface [polypeptide binding]; other site 1045856012860 Predicted periplasmic/secreted protein [Function unknown]; Region: COG3477 1045856012861 protease TldD; Provisional; Region: tldD; PRK10735 1045856012862 hypothetical protein; Provisional; Region: PRK10899 1045856012863 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 1045856012864 ribonuclease G; Provisional; Region: PRK11712 1045856012865 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 1045856012866 homodimer interface [polypeptide binding]; other site 1045856012867 oligonucleotide binding site [chemical binding]; other site 1045856012868 Maf-like protein; Region: Maf; pfam02545 1045856012869 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1045856012870 active site 1045856012871 dimer interface [polypeptide binding]; other site 1045856012872 rod shape-determining protein MreD; Provisional; Region: PRK11060 1045856012873 rod shape-determining protein MreC; Region: mreC; TIGR00219 1045856012874 rod shape-determining protein MreC; Region: MreC; pfam04085 1045856012875 rod shape-determining protein MreB; Provisional; Region: PRK13927 1045856012876 MreB and similar proteins; Region: MreB_like; cd10225 1045856012877 nucleotide binding site [chemical binding]; other site 1045856012878 Mg binding site [ion binding]; other site 1045856012879 putative protofilament interaction site [polypeptide binding]; other site 1045856012880 RodZ interaction site [polypeptide binding]; other site 1045856012881 regulatory protein CsrD; Provisional; Region: PRK11059 1045856012882 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1045856012883 metal binding site [ion binding]; metal-binding site 1045856012884 active site 1045856012885 I-site; other site 1045856012886 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1045856012887 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 1045856012888 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 1045856012889 NADP binding site [chemical binding]; other site 1045856012890 dimer interface [polypeptide binding]; other site 1045856012891 TMAO/DMSO reductase; Reviewed; Region: PRK05363 1045856012892 YedY_like molybdopterin cofactor (Moco) binding domain, a subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. Escherichia coli YedY has been propsed to form a heterodimer, consisting of a soluble catalytic subunit termed YedY; Region: YedY_like_Moco; cd02107 1045856012893 Moco binding site; other site 1045856012894 metal coordination site [ion binding]; other site 1045856012895 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 1045856012896 Dehydroquinase class II; Region: DHquinase_II; pfam01220 1045856012897 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 1045856012898 trimer interface [polypeptide binding]; other site 1045856012899 active site 1045856012900 dimer interface [polypeptide binding]; other site 1045856012901 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 1045856012902 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1045856012903 carboxyltransferase (CT) interaction site; other site 1045856012904 biotinylation site [posttranslational modification]; other site 1045856012905 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1045856012906 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1045856012907 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1045856012908 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1045856012909 hypothetical protein; Provisional; Region: PRK10633 1045856012910 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 1045856012911 Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; Region: SLC5sbd_PanF; cd10327 1045856012912 Na binding site [ion binding]; other site 1045856012913 ribosomal protein L11 methyltransferase; Region: prmA; TIGR00406 1045856012914 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1045856012915 Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124 1045856012916 active site 1045856012917 zinc binding site [ion binding]; other site 1045856012918 tRNA-dihydrouridine synthase B; Provisional; Region: PRK10415 1045856012919 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1045856012920 FMN binding site [chemical binding]; other site 1045856012921 active site 1045856012922 catalytic residues [active] 1045856012923 substrate binding site [chemical binding]; other site 1045856012924 Factor for inversion stimulation Fis, transcriptional activator [Transcription / DNA replication, recombination, and repair]; Region: Fis; COG2901 1045856012925 global DNA-binding transcriptional dual regulator Fis; Provisional; Region: fis; PRK00430 1045856012926 Protein of unknown function (DUF2556); Region: DUF2556; pfam10831 1045856012927 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 1045856012928 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 1045856012929 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 1045856012930 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1045856012931 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1045856012932 metal binding site [ion binding]; metal-binding site 1045856012933 active site 1045856012934 I-site; other site 1045856012935 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1045856012936 multidrug efflux system protein MdtE; Provisional; Region: PRK09859 1045856012937 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1045856012938 HlyD family secretion protein; Region: HlyD_3; pfam13437 1045856012939 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 1045856012940 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1045856012941 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1045856012942 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 1045856012943 substrate binding pocket [chemical binding]; other site 1045856012944 membrane-bound complex binding site; other site 1045856012945 hinge residues; other site 1045856012946 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597 1045856012947 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1045856012948 conserved gate region; other site 1045856012949 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1045856012950 dimer interface [polypeptide binding]; other site 1045856012951 conserved gate region; other site 1045856012952 putative PBP binding loops; other site 1045856012953 ABC-ATPase subunit interface; other site 1045856012954 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1045856012955 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1045856012956 dimer interface [polypeptide binding]; other site 1045856012957 conserved gate region; other site 1045856012958 putative PBP binding loops; other site 1045856012959 ABC-ATPase subunit interface; other site 1045856012960 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1045856012961 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1045856012962 Walker A/P-loop; other site 1045856012963 ATP binding site [chemical binding]; other site 1045856012964 Q-loop/lid; other site 1045856012965 ABC transporter signature motif; other site 1045856012966 Walker B; other site 1045856012967 D-loop; other site 1045856012968 H-loop/switch region; other site 1045856012969 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 1045856012970 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 1045856012971 trimer interface [polypeptide binding]; other site 1045856012972 putative metal binding site [ion binding]; other site 1045856012973 Protein of unknown function (DUF1488); Region: DUF1488; pfam07369 1045856012974 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 1045856012975 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1045856012976 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1045856012977 shikimate binding site; other site 1045856012978 NAD(P) binding site [chemical binding]; other site 1045856012979 tRNA(ANN) t(6)A37 threonylcarbamoyladenosine modification protein; Provisional; Region: PRK10634 1045856012980 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1045856012981 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 1045856012982 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1045856012983 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1045856012984 hypothetical protein; Validated; Region: PRK03430 1045856012985 hypothetical protein; Provisional; Region: PRK10736 1045856012986 DNA protecting protein DprA; Region: dprA; TIGR00732 1045856012987 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1045856012988 active site 1045856012989 catalytic residues [active] 1045856012990 metal binding site [ion binding]; metal-binding site 1045856012991 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1045856012992 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1045856012993 putative active site [active] 1045856012994 substrate binding site [chemical binding]; other site 1045856012995 putative cosubstrate binding site; other site 1045856012996 catalytic site [active] 1045856012997 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1045856012998 substrate binding site [chemical binding]; other site 1045856012999 16S rRNA methyltransferase B; Provisional; Region: PRK10901 1045856013000 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 1045856013001 putative RNA binding site [nucleotide binding]; other site 1045856013002 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1045856013003 S-adenosylmethionine binding site [chemical binding]; other site 1045856013004 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 1045856013005 TrkA-N domain; Region: TrkA_N; pfam02254 1045856013006 TrkA-C domain; Region: TrkA_C; pfam02080 1045856013007 TrkA-N domain; Region: TrkA_N; pfam02254 1045856013008 TrkA-C domain; Region: TrkA_C; pfam02080 1045856013009 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 1045856013010 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 1045856013011 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3036 1045856013012 zinc-responsive transcriptional regulator; Provisional; Region: zntR; PRK09514 1045856013013 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 1045856013014 DNA binding residues [nucleotide binding] 1045856013015 dimer interface [polypeptide binding]; other site 1045856013016 metal binding site [ion binding]; metal-binding site 1045856013017 hypothetical protein; Provisional; Region: PRK10203 1045856013018 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 1045856013019 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1045856013020 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1045856013021 alphaNTD homodimer interface [polypeptide binding]; other site 1045856013022 alphaNTD - beta interaction site [polypeptide binding]; other site 1045856013023 alphaNTD - beta' interaction site [polypeptide binding]; other site 1045856013024 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1045856013025 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1045856013026 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1045856013027 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1045856013028 RNA binding surface [nucleotide binding]; other site 1045856013029 30S ribosomal protein S11; Validated; Region: PRK05309 1045856013030 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 1045856013031 30S ribosomal protein S13; Region: bact_S13; TIGR03631 1045856013032 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1045856013033 SecY translocase; Region: SecY; pfam00344 1045856013034 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1045856013035 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 1045856013036 23S rRNA binding site [nucleotide binding]; other site 1045856013037 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1045856013038 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1045856013039 23S rRNA interface [nucleotide binding]; other site 1045856013040 5S rRNA interface [nucleotide binding]; other site 1045856013041 L27 interface [polypeptide binding]; other site 1045856013042 L5 interface [polypeptide binding]; other site 1045856013043 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1045856013044 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1045856013045 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1045856013046 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 1045856013047 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 1045856013048 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1045856013049 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1045856013050 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1045856013051 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1045856013052 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1045856013053 RNA binding site [nucleotide binding]; other site 1045856013054 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 1045856013055 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 1045856013056 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1045856013057 23S rRNA interface [nucleotide binding]; other site 1045856013058 putative translocon interaction site; other site 1045856013059 signal recognition particle (SRP54) interaction site; other site 1045856013060 L23 interface [polypeptide binding]; other site 1045856013061 trigger factor interaction site; other site 1045856013062 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1045856013063 23S rRNA interface [nucleotide binding]; other site 1045856013064 5S rRNA interface [nucleotide binding]; other site 1045856013065 putative antibiotic binding site [chemical binding]; other site 1045856013066 L25 interface [polypeptide binding]; other site 1045856013067 L27 interface [polypeptide binding]; other site 1045856013068 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 1045856013069 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1045856013070 G-X-X-G motif; other site 1045856013071 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1045856013072 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1045856013073 protein-rRNA interface [nucleotide binding]; other site 1045856013074 putative translocon binding site; other site 1045856013075 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 1045856013076 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1045856013077 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1045856013078 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1045856013079 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 1045856013080 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 1045856013081 50S ribosomal protein L3, bacterial; Region: L3_bact; TIGR03625 1045856013082 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 1045856013083 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 1045856013084 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 1045856013085 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 1045856013086 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 1045856013087 heme binding site [chemical binding]; other site 1045856013088 ferroxidase pore; other site 1045856013089 ferroxidase diiron center [ion binding]; other site 1045856013090 bacterioferritin-associated ferredoxin; Provisional; Region: PRK10509 1045856013091 elongation factor Tu; Reviewed; Region: PRK00049 1045856013092 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1045856013093 G1 box; other site 1045856013094 GEF interaction site [polypeptide binding]; other site 1045856013095 GTP/Mg2+ binding site [chemical binding]; other site 1045856013096 Switch I region; other site 1045856013097 G2 box; other site 1045856013098 G3 box; other site 1045856013099 Switch II region; other site 1045856013100 G4 box; other site 1045856013101 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1045856013102 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1045856013103 Antibiotic Binding Site [chemical binding]; other site 1045856013104 elongation factor G; Reviewed; Region: PRK00007 1045856013105 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1045856013106 G1 box; other site 1045856013107 putative GEF interaction site [polypeptide binding]; other site 1045856013108 GTP/Mg2+ binding site [chemical binding]; other site 1045856013109 Switch I region; other site 1045856013110 G2 box; other site 1045856013111 G3 box; other site 1045856013112 Switch II region; other site 1045856013113 G4 box; other site 1045856013114 G5 box; other site 1045856013115 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1045856013116 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1045856013117 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1045856013118 30S ribosomal protein S7; Validated; Region: PRK05302 1045856013119 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1045856013120 S17 interaction site [polypeptide binding]; other site 1045856013121 S8 interaction site; other site 1045856013122 16S rRNA interaction site [nucleotide binding]; other site 1045856013123 streptomycin interaction site [chemical binding]; other site 1045856013124 23S rRNA interaction site [nucleotide binding]; other site 1045856013125 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1045856013126 sulfur transfer complex subunit TusB; Provisional; Region: PRK13510 1045856013127 sulfur relay protein TusC; Validated; Region: PRK00211 1045856013128 sulfur transfer complex subunit TusD; Validated; Region: PRK00207 1045856013129 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 1045856013130 YheO-like PAS domain; Region: PAS_6; pfam08348 1045856013131 HTH domain; Region: HTH_22; pfam13309 1045856013132 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK10902 1045856013133 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 1045856013134 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1045856013135 phi X174 lysis protein; Provisional; Region: PRK02793 1045856013136 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 1045856013137 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1045856013138 Predicted nucleic-acid-binding protein containing a Zn-ribbon domain [General function prediction only]; Region: COG3529 1045856013139 glutathione-regulated potassium-efflux system protein KefB; Provisional; Region: PRK03659 1045856013140 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 1045856013141 TrkA-N domain; Region: TrkA_N; pfam02254 1045856013142 glutathione-regulated potassium-efflux system ancillary protein KefG; Provisional; Region: PRK04930 1045856013143 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 1045856013144 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1045856013145 Walker A/P-loop; other site 1045856013146 ATP binding site [chemical binding]; other site 1045856013147 Q-loop/lid; other site 1045856013148 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1045856013149 ABC transporter signature motif; other site 1045856013150 Walker B; other site 1045856013151 D-loop; other site 1045856013152 ABC transporter; Region: ABC_tran_2; pfam12848 1045856013153 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1045856013154 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 1045856013155 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1045856013156 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1045856013157 The C-terminal substrate-binding domian of LysR-type transcriptional regulator MdcR, which involved in the malonate catabolism contains the type 2 periplasmic binding fold; Region: PBP2_MdcR; cd08416 1045856013158 putative dimerization interface [polypeptide binding]; other site 1045856013159 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1045856013160 malonate decarboxylase, epsilon subunit; Region: malonate_mdcH; TIGR03131 1045856013161 phosphoribosyl-dephospho-CoA transferase; Provisional; Region: PRK01293 1045856013162 Phosphoribosyl-dephospho-CoA transferase MdcG; Region: MdcG; pfam10620 1045856013163 Membrane transport protein; Region: Mem_trans; cl09117 1045856013164 Malonate decarboxylase gamma subunit (MdcE); Region: MdcE; pfam06833 1045856013165 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189 1045856013166 Malonate decarboxylase delta subunit (MdcD); Region: ACP; cl06082 1045856013167 triphosphoribosyl-dephospho-CoA synthase; Validated; Region: PRK01237 1045856013168 malonate decarboxylase, alpha subunit; Region: mdcA; TIGR01110 1045856013169 Coenzyme A transferase; Region: CoA_trans; cl17247 1045856013170 putative hydrolase; Provisional; Region: PRK10985 1045856013171 hypothetical protein; Provisional; Region: PRK04966 1045856013172 phosphoribulokinase; Provisional; Region: PRK15453 1045856013173 active site 1045856013174 hypothetical protein; Provisional; Region: PRK10738 1045856013175 DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753 1045856013176 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1045856013177 ligand binding site [chemical binding]; other site 1045856013178 flexible hinge region; other site 1045856013179 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1045856013180 putative switch regulator; other site 1045856013181 non-specific DNA interactions [nucleotide binding]; other site 1045856013182 DNA binding site [nucleotide binding] 1045856013183 sequence specific DNA binding site [nucleotide binding]; other site 1045856013184 putative cAMP binding site [chemical binding]; other site 1045856013185 integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667 1045856013186 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 1045856013187 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1045856013188 bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093 1045856013189 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1045856013190 inhibitor-cofactor binding pocket; inhibition site 1045856013191 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1045856013192 catalytic residue [active] 1045856013193 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 1045856013194 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1045856013195 glutamine binding [chemical binding]; other site 1045856013196 catalytic triad [active] 1045856013197 Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184 1045856013198 cell filamentation protein Fic; Provisional; Region: PRK10347 1045856013199 hypothetical protein; Provisional; Region: PRK10204 1045856013200 peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903 1045856013201 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 1045856013202 substrate binding site [chemical binding]; other site 1045856013203 putative transporter; Provisional; Region: PRK03699 1045856013204 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1045856013205 putative substrate translocation pore; other site 1045856013206 cytosine deaminase; Provisional; Region: PRK09230 1045856013207 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 1045856013208 active site 1045856013209 nitrite reductase subunit NirD; Provisional; Region: PRK14989 1045856013210 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1045856013211 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1045856013212 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1045856013213 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 1045856013214 siroheme synthase; Provisional; Region: cysG; PRK10637 1045856013215 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 1045856013216 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 1045856013217 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1045856013218 active site 1045856013219 SAM binding site [chemical binding]; other site 1045856013220 homodimer interface [polypeptide binding]; other site 1045856013221 Protein of unknown function (DUF4223); Region: DUF4223; pfam13978 1045856013222 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1045856013223 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1045856013224 active site 1045856013225 HIGH motif; other site 1045856013226 dimer interface [polypeptide binding]; other site 1045856013227 KMSKS motif; other site 1045856013228 phosphoglycolate phosphatase; Provisional; Region: PRK13222 1045856013229 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1045856013230 motif II; other site 1045856013231 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1045856013232 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 1045856013233 substrate binding site [chemical binding]; other site 1045856013234 hexamer interface [polypeptide binding]; other site 1045856013235 metal binding site [ion binding]; metal-binding site 1045856013236 DNA adenine methylase; Provisional; Region: PRK10904 1045856013237 cell division protein DamX; Validated; Region: PRK10905 1045856013238 cell division protein DamX; Validated; Region: PRK10905 1045856013239 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 1045856013240 active site 1045856013241 dimer interface [polypeptide binding]; other site 1045856013242 metal binding site [ion binding]; metal-binding site 1045856013243 shikimate kinase; Reviewed; Region: aroK; PRK00131 1045856013244 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1045856013245 ADP binding site [chemical binding]; other site 1045856013246 magnesium binding site [ion binding]; other site 1045856013247 putative shikimate binding site; other site 1045856013248 outer membrane porin HofQ; Provisional; Region: hofQ; PRK10560 1045856013249 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1045856013250 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1045856013251 Protein of unknown function (DUF2531); Region: DUF2531; pfam10748 1045856013252 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 1045856013253 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 1045856013254 Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972 1045856013255 penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636 1045856013256 Transglycosylase; Region: Transgly; pfam00912 1045856013257 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1045856013258 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 1045856013259 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1045856013260 ADP-ribose binding site [chemical binding]; other site 1045856013261 dimer interface [polypeptide binding]; other site 1045856013262 active site 1045856013263 nudix motif; other site 1045856013264 metal binding site [ion binding]; metal-binding site 1045856013265 Intracellular growth attenuator protein IgaA; Region: IgaA; pfam07095 1045856013266 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 1045856013267 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1045856013268 motif II; other site 1045856013269 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1045856013270 RNA binding surface [nucleotide binding]; other site 1045856013271 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 1045856013272 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 1045856013273 dimerization interface [polypeptide binding]; other site 1045856013274 domain crossover interface; other site 1045856013275 redox-dependent activation switch; other site 1045856013276 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 1045856013277 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 1045856013278 active site 1045856013279 substrate-binding site [chemical binding]; other site 1045856013280 metal-binding site [ion binding] 1045856013281 ATP binding site [chemical binding]; other site 1045856013282 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 1045856013283 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1045856013284 dimerization interface [polypeptide binding]; other site 1045856013285 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1045856013286 dimer interface [polypeptide binding]; other site 1045856013287 phosphorylation site [posttranslational modification] 1045856013288 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1045856013289 ATP binding site [chemical binding]; other site 1045856013290 G-X-G motif; other site 1045856013291 osmolarity response regulator; Provisional; Region: ompR; PRK09468 1045856013292 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1045856013293 active site 1045856013294 phosphorylation site [posttranslational modification] 1045856013295 intermolecular recognition site; other site 1045856013296 dimerization interface [polypeptide binding]; other site 1045856013297 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1045856013298 DNA binding site [nucleotide binding] 1045856013299 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 1045856013300 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1045856013301 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1045856013302 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 1045856013303 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 1045856013304 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 1045856013305 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 1045856013306 RNA binding site [nucleotide binding]; other site 1045856013307 ferrous iron transport protein A; Reviewed; Region: feoA; PRK09555 1045856013308 ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554 1045856013309 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 1045856013310 G1 box; other site 1045856013311 GTP/Mg2+ binding site [chemical binding]; other site 1045856013312 Switch I region; other site 1045856013313 G2 box; other site 1045856013314 G3 box; other site 1045856013315 Switch II region; other site 1045856013316 G4 box; other site 1045856013317 G5 box; other site 1045856013318 Nucleoside recognition; Region: Gate; pfam07670 1045856013319 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 1045856013320 Nucleoside recognition; Region: Gate; pfam07670 1045856013321 ferrous iron transport protein FeoC; Provisional; Region: PRK15431 1045856013322 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1045856013323 carboxylesterase BioH; Provisional; Region: PRK10349 1045856013324 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1045856013325 DNA utilization protein GntX; Provisional; Region: PRK11595 1045856013326 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1045856013327 active site 1045856013328 Fe/S biogenesis protein NfuA; Provisional; Region: PRK11190 1045856013329 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 1045856013330 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 1045856013331 high-affinity gluconate transporter; Provisional; Region: PRK14984 1045856013332 gluconate transporter; Region: gntP; TIGR00791 1045856013333 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 1045856013334 4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711 1045856013335 maltodextrin phosphorylase; Provisional; Region: PRK14985 1045856013336 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 1045856013337 active site pocket [active] 1045856013338 transcriptional regulator MalT; Provisional; Region: PRK04841 1045856013339 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1045856013340 DNA binding residues [nucleotide binding] 1045856013341 dimerization interface [polypeptide binding]; other site 1045856013342 DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906 1045856013343 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1045856013344 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1045856013345 intramembrane serine protease GlpG; Provisional; Region: PRK10907 1045856013346 Protein of unknown function (DUF3582); Region: DUF3582; pfam12122 1045856013347 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 1045856013348 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 1045856013349 active site residue [active] 1045856013350 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 1045856013351 glycogen phosphorylase; Provisional; Region: PRK14986 1045856013352 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 1045856013353 homodimer interface [polypeptide binding]; other site 1045856013354 active site pocket [active] 1045856013355 glycogen synthase; Provisional; Region: glgA; PRK00654 1045856013356 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 1045856013357 ADP-binding pocket [chemical binding]; other site 1045856013358 homodimer interface [polypeptide binding]; other site 1045856013359 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 1045856013360 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 1045856013361 ligand binding site; other site 1045856013362 oligomer interface; other site 1045856013363 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 1045856013364 dimer interface [polypeptide binding]; other site 1045856013365 N-terminal domain interface [polypeptide binding]; other site 1045856013366 sulfate 1 binding site; other site 1045856013367 glycogen debranching enzyme; Provisional; Region: PRK03705 1045856013368 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 1045856013369 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 1045856013370 active site 1045856013371 catalytic site [active] 1045856013372 glycogen branching enzyme; Provisional; Region: PRK05402 1045856013373 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 1045856013374 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 1045856013375 active site 1045856013376 catalytic site [active] 1045856013377 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 1045856013378 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 1045856013379 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1045856013380 putative antibiotic transporter; Provisional; Region: PRK10739 1045856013381 low affinity gluconate transporter; Provisional; Region: PRK10472 1045856013382 gluconate transporter; Region: gntP; TIGR00791 1045856013383 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 1045856013384 ATP-binding site [chemical binding]; other site 1045856013385 Gluconate-6-phosphate binding site [chemical binding]; other site 1045856013386 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 1045856013387 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1045856013388 DNA binding site [nucleotide binding] 1045856013389 domain linker motif; other site 1045856013390 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 1045856013391 putative ligand binding site [chemical binding]; other site 1045856013392 putative dimerization interface [polypeptide binding]; other site 1045856013393 Pirin-related protein [General function prediction only]; Region: COG1741 1045856013394 Pirin; Region: Pirin; pfam02678 1045856013395 putative oxidoreductase; Provisional; Region: PRK10206 1045856013396 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1045856013397 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1045856013398 putative acetyltransferase YhhY; Provisional; Region: PRK10140 1045856013399 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1045856013400 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1045856013401 Coenzyme A binding pocket [chemical binding]; other site 1045856013402 gamma-glutamyltranspeptidase; Reviewed; Region: ggt; PRK09615 1045856013403 gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066 1045856013404 cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454 1045856013405 Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562 1045856013406 putative active site [active] 1045856013407 catalytic site [active] 1045856013408 putative metal binding site [ion binding]; other site 1045856013409 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1045856013410 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1045856013411 Walker A/P-loop; other site 1045856013412 ATP binding site [chemical binding]; other site 1045856013413 Q-loop/lid; other site 1045856013414 ABC transporter signature motif; other site 1045856013415 Walker B; other site 1045856013416 D-loop; other site 1045856013417 H-loop/switch region; other site 1045856013418 TOBE domain; Region: TOBE_2; pfam08402 1045856013419 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1045856013420 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1045856013421 dimer interface [polypeptide binding]; other site 1045856013422 conserved gate region; other site 1045856013423 putative PBP binding loops; other site 1045856013424 ABC-ATPase subunit interface; other site 1045856013425 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1045856013426 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1045856013427 putative PBP binding loops; other site 1045856013428 dimer interface [polypeptide binding]; other site 1045856013429 ABC-ATPase subunit interface; other site 1045856013430 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1045856013431 glycerol-3-phosphate transporter periplasmic binding protein; Provisional; Region: PRK10974 1045856013432 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livF; PRK11614 1045856013433 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1045856013434 Walker A/P-loop; other site 1045856013435 ATP binding site [chemical binding]; other site 1045856013436 Q-loop/lid; other site 1045856013437 ABC transporter signature motif; other site 1045856013438 Walker B; other site 1045856013439 D-loop; other site 1045856013440 H-loop/switch region; other site 1045856013441 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 1045856013442 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1045856013443 Walker A/P-loop; other site 1045856013444 ATP binding site [chemical binding]; other site 1045856013445 Q-loop/lid; other site 1045856013446 ABC transporter signature motif; other site 1045856013447 Walker B; other site 1045856013448 D-loop; other site 1045856013449 H-loop/switch region; other site 1045856013450 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 1045856013451 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 1045856013452 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1045856013453 TM-ABC transporter signature motif; other site 1045856013454 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1045856013455 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1045856013456 TM-ABC transporter signature motif; other site 1045856013457 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1045856013458 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 1045856013459 dimerization interface [polypeptide binding]; other site 1045856013460 ligand binding site [chemical binding]; other site 1045856013461 Acetyltransferase (GNAT) domain; Region: DUF3749; pfam12568 1045856013462 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1045856013463 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 1045856013464 dimerization interface [polypeptide binding]; other site 1045856013465 ligand binding site [chemical binding]; other site 1045856013466 4-aminobutyrate aminotransferase; Provisional; Region: PRK06777 1045856013467 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1045856013468 inhibitor-cofactor binding pocket; inhibition site 1045856013469 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1045856013470 catalytic residue [active] 1045856013471 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 1045856013472 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1045856013473 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1045856013474 DNA binding residues [nucleotide binding] 1045856013475 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 1045856013476 putative protein insertion permease FtsX; Region: ftsX; TIGR00439 1045856013477 cell division protein FtsE; Provisional; Region: PRK10908 1045856013478 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1045856013479 Walker A/P-loop; other site 1045856013480 ATP binding site [chemical binding]; other site 1045856013481 Q-loop/lid; other site 1045856013482 ABC transporter signature motif; other site 1045856013483 Walker B; other site 1045856013484 D-loop; other site 1045856013485 H-loop/switch region; other site 1045856013486 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 1045856013487 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 1045856013488 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1045856013489 P loop; other site 1045856013490 GTP binding site [chemical binding]; other site 1045856013491 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 1045856013492 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1045856013493 S-adenosylmethionine binding site [chemical binding]; other site 1045856013494 hypothetical protein; Provisional; Region: PRK10910 1045856013495 Protein of unknown function (DUF2500); Region: DUF2500; pfam10694 1045856013496 Predicted membrane protein [Function unknown]; Region: COG3714 1045856013497 zinc/cadmium/mercury/lead-transporting ATPase; Provisional; Region: zntA; PRK11033 1045856013498 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1045856013499 metal-binding site [ion binding] 1045856013500 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1045856013501 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1045856013502 DctM-like transporters; Region: DctM; pfam06808 1045856013503 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 1045856013504 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 1045856013505 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 1045856013506 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 1045856013507 SirA (also known as UvrY, and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A...; Region: SirA; cd03423 1045856013508 CPxP motif; other site 1045856013509 hypothetical protein; Provisional; Region: PRK11212 1045856013510 hypothetical protein; Provisional; Region: PRK11615 1045856013511 major facilitator superfamily transporter; Provisional; Region: PRK05122 1045856013512 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1045856013513 putative substrate translocation pore; other site 1045856013514 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 1045856013515 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1045856013516 O-methyltransferase; Region: Methyltransf_2; pfam00891 1045856013517 Beta-ketoacyl synthase, N-terminal domain; Region: Ketoacyl-synt_2; pfam13723 1045856013518 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1045856013519 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1045856013520 putative acyl-acceptor binding pocket; other site 1045856013521 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1045856013522 acyl carrier protein; Provisional; Region: PRK05350 1045856013523 Predicted membrane protein [Function unknown]; Region: COG4648 1045856013524 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 1045856013525 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1045856013526 acyl-activating enzyme (AAE) consensus motif; other site 1045856013527 AMP binding site [chemical binding]; other site 1045856013528 active site 1045856013529 CoA binding site [chemical binding]; other site 1045856013530 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1045856013531 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1045856013532 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 1045856013533 Ligand binding site; other site 1045856013534 Putative Catalytic site; other site 1045856013535 DXD motif; other site 1045856013536 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1045856013537 putative acyl-acceptor binding pocket; other site 1045856013538 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1045856013539 active site 1045856013540 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 1045856013541 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 1045856013542 Predicted exporter [General function prediction only]; Region: COG4258 1045856013543 Protein of unknown function (DUF3261); Region: DUF3261; pfam11659 1045856013544 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK09185 1045856013545 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1045856013546 dimer interface [polypeptide binding]; other site 1045856013547 active site 1045856013548 Domain of unknown function, appears to be related to a diverse group of beta-hydroxydecanoyl ACP dehydratases (FabA) and beta-hydroxyacyl ACP dehydratases (FabZ). This group appears to lack the conserved active site histidine of FabA and FabZ; Region: FabA_like; cd01289 1045856013549 putative active site 1 [active] 1045856013550 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1045856013551 3-oxoacyl-(acyl-carrier-protein) reductase, putative; Region: fabG_rel; TIGR01831 1045856013552 NAD(P) binding site [chemical binding]; other site 1045856013553 active site 1045856013554 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK09116 1045856013555 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1045856013556 dimer interface [polypeptide binding]; other site 1045856013557 active site 1045856013558 holo-(acyl carrier protein) synthase 2; Provisional; Region: PRK10351 1045856013559 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 1045856013560 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971 1045856013561 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051 1045856013562 4-amino-4-deoxy-L-arabinose transferase; Provisional; Region: arnT; PRK13279 1045856013563 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 1045856013564 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD; Provisional; Region: PRK15394 1045856013565 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 1045856013566 bifunctional UDP-glucuronic acid decarboxylase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase; Validated; Region: PRK08125 1045856013567 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 1045856013568 active site 1045856013569 substrate binding site [chemical binding]; other site 1045856013570 cosubstrate binding site; other site 1045856013571 catalytic site [active] 1045856013572 C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702 1045856013573 active site 1045856013574 hexamer interface [polypeptide binding]; other site 1045856013575 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 1045856013576 NAD binding site [chemical binding]; other site 1045856013577 substrate binding site [chemical binding]; other site 1045856013578 active site 1045856013579 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 1045856013580 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1045856013581 Ligand binding site; other site 1045856013582 Putative Catalytic site; other site 1045856013583 DXD motif; other site 1045856013584 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1045856013585 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1045856013586 inhibitor-cofactor binding pocket; inhibition site 1045856013587 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1045856013588 catalytic residue [active] 1045856013589 Phenolic acid decarboxylase (PAD); Region: PA_decarbox; pfam05870 1045856013590 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1045856013591 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1045856013592 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1045856013593 dimerization interface [polypeptide binding]; other site 1045856013594 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1045856013595 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1045856013596 NAD(P) binding site [chemical binding]; other site 1045856013597 active site 1045856013598 NlpC/P60 family; Region: NLPC_P60; pfam00877 1045856013599 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1045856013600 Integral membrane protein TerC family; Region: TerC; cl10468 1045856013601 Ion channel; Region: Ion_trans_2; pfam07885 1045856013602 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1045856013603 D-galactonate transporter; Region: 2A0114; TIGR00893 1045856013604 putative substrate translocation pore; other site 1045856013605 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1045856013606 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1045856013607 Bacterial transcriptional regulator; Region: IclR; pfam01614 1045856013608 hypothetical protein; Validated; Region: PRK06201 1045856013609 Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684 1045856013610 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1045856013611 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 1045856013612 ligand binding site [chemical binding]; other site 1045856013613 NAD binding site [chemical binding]; other site 1045856013614 dimerization interface [polypeptide binding]; other site 1045856013615 catalytic site [active] 1045856013616 Predicted flavoproteins [General function prediction only]; Region: COG2081 1045856013617 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1045856013618 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1045856013619 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1045856013620 universal stress protein UspB; Provisional; Region: PRK04960 1045856013621 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1045856013622 Ligand Binding Site [chemical binding]; other site 1045856013623 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1045856013624 S-adenosylmethionine binding site [chemical binding]; other site 1045856013625 oligopeptidase A; Provisional; Region: PRK10911 1045856013626 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 1045856013627 active site 1045856013628 Zn binding site [ion binding]; other site 1045856013629 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 1045856013630 glutathione reductase; Validated; Region: PRK06116 1045856013631 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1045856013632 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1045856013633 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1045856013634 trehalase; Provisional; Region: treF; PRK13270 1045856013635 Trehalase; Region: Trehalase; pfam01204 1045856013636 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1045856013637 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1045856013638 Coenzyme A binding pocket [chemical binding]; other site 1045856013639 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 1045856013640 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1045856013641 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1045856013642 DNA binding residues [nucleotide binding] 1045856013643 dimerization interface [polypeptide binding]; other site 1045856013644 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1045856013645 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1045856013646 NAD(P) binding site [chemical binding]; other site 1045856013647 active site 1045856013648 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1045856013649 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1045856013650 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 1045856013651 putative effector binding pocket; other site 1045856013652 putative dimerization interface [polypeptide binding]; other site 1045856013653 inner membrane protein YhjD; Region: TIGR00766 1045856013654 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1045856013655 metabolite-proton symporter; Region: 2A0106; TIGR00883 1045856013656 putative substrate translocation pore; other site 1045856013657 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 1045856013658 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 1045856013659 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1045856013660 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1045856013661 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1045856013662 substrate binding site [chemical binding]; other site 1045856013663 ATP binding site [chemical binding]; other site 1045856013664 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1045856013665 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1045856013666 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 1045856013667 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1045856013668 putative diguanylate cyclase; Provisional; Region: PRK13561 1045856013669 HAMP domain; Region: HAMP; pfam00672 1045856013670 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1045856013671 metal binding site [ion binding]; metal-binding site 1045856013672 active site 1045856013673 I-site; other site 1045856013674 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1045856013675 cellulose synthase subunit BcsC; Provisional; Region: PRK11447 1045856013676 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1045856013677 binding surface 1045856013678 TPR motif; other site 1045856013679 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1045856013680 binding surface 1045856013681 TPR motif; other site 1045856013682 Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420 1045856013683 endo-1,4-D-glucanase; Provisional; Region: PRK11097 1045856013684 cellulose synthase regulator protein; Provisional; Region: PRK11114 1045856013685 cellulose synthase catalytic subunit; Provisional; Region: bcsA; PRK11498 1045856013686 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1045856013687 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 1045856013688 DXD motif; other site 1045856013689 PilZ domain; Region: PilZ; pfam07238 1045856013690 cell division protein; Provisional; Region: PRK10037 1045856013691 cellulose biosynthesis protein BcsE; Provisional; Region: PRK15045 1045856013692 Protein of unknown function (DUF2819); Region: DUF2819; pfam10995 1045856013693 Protein of unknown function (DUF2636); Region: DUF2636; pfam11120 1045856013694 Protein of unknown function (DUF3260); Region: DUF3260; pfam11658 1045856013695 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 1045856013696 Biotin operon repressor [Transcription]; Region: BirA; COG1654 1045856013697 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 1045856013698 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 1045856013699 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 1045856013700 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 1045856013701 FAD binding domain; Region: FAD_binding_4; pfam01565 1045856013702 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1045856013703 protoporphyrinogen oxidase; Provisional; Region: hemG; PRK11104 1045856013704 potassium transporter; Provisional; Region: PRK10750 1045856013705 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 1045856013706 hypothetical protein; Provisional; Region: PRK11568 1045856013707 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 1045856013708 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 1045856013709 proline dipeptidase; Provisional; Region: PRK13607 1045856013710 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 1045856013711 active site 1045856013712 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 1045856013713 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1045856013714 substrate binding site [chemical binding]; other site 1045856013715 oxyanion hole (OAH) forming residues; other site 1045856013716 trimer interface [polypeptide binding]; other site 1045856013717 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1045856013718 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1045856013719 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1045856013720 3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947 1045856013721 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1045856013722 dimer interface [polypeptide binding]; other site 1045856013723 active site 1045856013724 FMN reductase; Validated; Region: fre; PRK08051 1045856013725 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 1045856013726 FAD binding pocket [chemical binding]; other site 1045856013727 FAD binding motif [chemical binding]; other site 1045856013728 phosphate binding motif [ion binding]; other site 1045856013729 beta-alpha-beta structure motif; other site 1045856013730 NAD binding pocket [chemical binding]; other site 1045856013731 3-octaprenyl-4-hydroxybenzoate decarboxylase; Provisional; Region: PRK10922 1045856013732 transcriptional activator RfaH; Provisional; Region: rfaH; PRK09014 1045856013733 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), RfaH; Region: NGN_SP_RfaH; cd09892 1045856013734 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1045856013735 active site 1045856013736 twin-arginine protein translocation system subunit TatC; Provisional; Region: PRK10921 1045856013737 sec-independent translocase; Provisional; Region: PRK01770 1045856013738 twin arginine translocase protein A; Provisional; Region: tatA; PRK03554 1045856013739 putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750 1045856013740 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 1045856013741 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 1045856013742 SCP-2 sterol transfer family; Region: SCP2; pfam02036 1045856013743 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 1045856013744 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1045856013745 S-adenosylmethionine binding site [chemical binding]; other site 1045856013746 DNA recombination protein RmuC; Provisional; Region: PRK10361 1045856013747 RmuC family; Region: RmuC; pfam02646 1045856013748 uridine phosphorylase; Provisional; Region: PRK11178 1045856013749 uridine phosphorylase; Region: Uridine-psphlse; TIGR01718 1045856013750 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1045856013751 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1045856013752 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 1045856013753 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 1045856013754 THF binding site; other site 1045856013755 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1045856013756 substrate binding site [chemical binding]; other site 1045856013757 THF binding site; other site 1045856013758 zinc-binding site [ion binding]; other site 1045856013759 DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421 1045856013760 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1045856013761 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 1045856013762 putative dimerization interface [polypeptide binding]; other site 1045856013763 EamA-like transporter family; Region: EamA; pfam00892 1045856013764 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1045856013765 putative hydrolase; Provisional; Region: PRK10976 1045856013766 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1045856013767 active site 1045856013768 motif I; other site 1045856013769 motif II; other site 1045856013770 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1045856013771 lysophospholipase L2; Provisional; Region: PRK10749 1045856013772 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1045856013773 homoserine/homoserine lactone efflux protein; Provisional; Region: rhtB; PRK10520 1045856013774 threonine efflux system; Provisional; Region: PRK10229 1045856013775 ATP-dependent DNA helicase RecQ; Provisional; Region: PRK11057 1045856013776 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1045856013777 ATP binding site [chemical binding]; other site 1045856013778 putative Mg++ binding site [ion binding]; other site 1045856013779 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1045856013780 nucleotide binding region [chemical binding]; other site 1045856013781 ATP-binding site [chemical binding]; other site 1045856013782 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 1045856013783 Helicase and RNase D C-terminal; Region: HRDC; smart00341 1045856013784 The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541 1045856013785 dimerization interface [polypeptide binding]; other site 1045856013786 substrate binding site [chemical binding]; other site 1045856013787 active site 1045856013788 calcium binding site [ion binding]; other site 1045856013789 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1045856013790 CoenzymeA binding site [chemical binding]; other site 1045856013791 subunit interaction site [polypeptide binding]; other site 1045856013792 PHB binding site; other site 1045856013793 putative chloramphenical resistance permease RarD; Provisional; Region: PRK15430 1045856013794 EamA-like transporter family; Region: EamA; pfam00892 1045856013795 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1045856013796 Escherichia coli Mg2+ transporter CorA_like subgroup; Region: EcCorA-like_1; cd12835 1045856013797 Cl binding site [ion binding]; other site 1045856013798 oligomer interface [polypeptide binding]; other site 1045856013799 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 1045856013800 Part of AAA domain; Region: AAA_19; pfam13245 1045856013801 Family description; Region: UvrD_C_2; pfam13538 1045856013802 flavin mononucleotide phosphatase; Provisional; Region: PRK10748 1045856013803 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1045856013804 motif II; other site 1045856013805 Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973 1045856013806 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1045856013807 active site 1045856013808 DNA binding site [nucleotide binding] 1045856013809 Int/Topo IB signature motif; other site 1045856013810 hypothetical protein; Provisional; Region: PRK10963 1045856013811 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 1045856013812 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1045856013813 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1045856013814 Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate...; Region: Frataxin; cd00503 1045856013815 putative iron binding site [ion binding]; other site 1045856013816 Adenylate cyclase [Nucleotide transport and metabolism]; Region: CyaA; COG3072 1045856013817 Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633 1045856013818 Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295 1045856013819 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 1045856013820 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 1045856013821 domain interfaces; other site 1045856013822 active site 1045856013823 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 1045856013824 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1045856013825 active site 1045856013826 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 1045856013827 Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemX; COG2959 1045856013828 putative protoheme IX biogenesis protein; Provisional; Region: PRK10747 1045856013829 HemY protein N-terminus; Region: HemY_N; pfam07219 1045856013830 putative transport protein YifK; Provisional; Region: PRK10746 1045856013831 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 1045856013832 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 1045856013833 putative common antigen polymerase; Provisional; Region: PRK02975 1045856013834 4-alpha-L-fucosyltransferase glycosyl transferase group 56; Region: Glyco_transf_56; pfam07429 1045856013835 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1045856013836 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_10; cd13125 1045856013837 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1045856013838 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1045856013839 inhibitor-cofactor binding pocket; inhibition site 1045856013840 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1045856013841 catalytic residue [active] 1045856013842 TDP-fucosamine acetyltransferase; Provisional; Region: PRK10975 1045856013843 UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064 1045856013844 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1045856013845 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1045856013846 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1045856013847 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 1045856013848 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 1045856013849 active site 1045856013850 homodimer interface [polypeptide binding]; other site 1045856013851 lipopolysaccharide biosynthesis protein WzzE; Provisional; Region: PRK11638 1045856013852 Chain length determinant protein; Region: Wzz; pfam02706 1045856013853 undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase; Provisional; Region: PRK15119 1045856013854 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 1045856013855 Mg++ binding site [ion binding]; other site 1045856013856 putative catalytic motif [active] 1045856013857 substrate binding site [chemical binding]; other site 1045856013858 transcription termination factor Rho; Provisional; Region: rho; PRK09376 1045856013859 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 1045856013860 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 1045856013861 RNA binding site [nucleotide binding]; other site 1045856013862 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 1045856013863 multimer interface [polypeptide binding]; other site 1045856013864 Walker A motif; other site 1045856013865 ATP binding site [chemical binding]; other site 1045856013866 Walker B motif; other site 1045856013867 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1045856013868 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1045856013869 catalytic residues [active] 1045856013870 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 1045856013871 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1045856013872 ATP binding site [chemical binding]; other site 1045856013873 Mg++ binding site [ion binding]; other site 1045856013874 motif III; other site 1045856013875 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1045856013876 nucleotide binding region [chemical binding]; other site 1045856013877 ATP-binding site [chemical binding]; other site 1045856013878 guanosine pentaphosphate phosphohydrolase; Provisional; Region: PRK11031 1045856013879 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1045856013880 ATP-dependent DNA helicase Rep; Provisional; Region: PRK10919 1045856013881 Part of AAA domain; Region: AAA_19; pfam13245 1045856013882 Family description; Region: UvrD_C_2; pfam13538 1045856013883 peptidyl-prolyl cis-trans isomerase C; Provisional; Region: PRK15441 1045856013884 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 1045856013885 ketol-acid reductoisomerase; Validated; Region: PRK05225 1045856013886 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 1045856013887 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1045856013888 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1045856013889 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1045856013890 DNA-binding transcriptional regulator IlvY; Provisional; Region: PRK11716 1045856013891 The C-terminal substrate binding of LysR-type transcriptional regulator IlvY, which activates the expression of ilvC gene that encoding acetohydroxy acid isomeroreductase for the biosynthesis of branched amino acids; contains the type 2 periplasmic bindin; Region: PBP2_IlvY; cd08430 1045856013892 putative dimerization interface [polypeptide binding]; other site 1045856013893 threonine dehydratase; Reviewed; Region: PRK09224 1045856013894 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1045856013895 tetramer interface [polypeptide binding]; other site 1045856013896 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1045856013897 catalytic residue [active] 1045856013898 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 1045856013899 putative Ile/Val binding site [chemical binding]; other site 1045856013900 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 1045856013901 putative Ile/Val binding site [chemical binding]; other site 1045856013902 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 1045856013903 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1045856013904 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1045856013905 homodimer interface [polypeptide binding]; other site 1045856013906 substrate-cofactor binding pocket; other site 1045856013907 catalytic residue [active] 1045856013908 acetolactate synthase 2 regulatory subunit; Provisional; Region: ilvM; PRK11152 1045856013909 acetolactate synthase 2 catalytic subunit; Reviewed; Region: PRK08978 1045856013910 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1045856013911 PYR/PP interface [polypeptide binding]; other site 1045856013912 dimer interface [polypeptide binding]; other site 1045856013913 TPP binding site [chemical binding]; other site 1045856013914 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1045856013915 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1045856013916 TPP-binding site [chemical binding]; other site 1045856013917 dimer interface [polypeptide binding]; other site 1045856013918 hypothetical protein; Provisional; Region: PRK11027 1045856013919 transcriptional regulator HdfR; Provisional; Region: PRK03601 1045856013920 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1045856013921 glutamate racemase; Provisional; Region: PRK00865 1045856013922 vitamin B12/cobalamin outer membrane transporter; Provisional; Region: btuB; PRK10641 1045856013923 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1045856013924 N-terminal plug; other site 1045856013925 ligand-binding site [chemical binding]; other site 1045856013926 tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031 1045856013927 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1045856013928 S-adenosylmethionine binding site [chemical binding]; other site 1045856013929 hypothetical protein; Provisional; Region: PRK11056 1045856013930 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 1045856013931 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1045856013932 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 1045856013933 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1045856013934 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1045856013935 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 1045856013936 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1045856013937 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 1045856013938 dimerization interface [polypeptide binding]; other site 1045856013939 argininosuccinate lyase; Provisional; Region: PRK04833 1045856013940 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1045856013941 active sites [active] 1045856013942 tetramer interface [polypeptide binding]; other site 1045856013943 AAK_NAGK-NC: N-Acetyl-L-glutamate kinase - noncyclic (NAGK-NC) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of microbial arginine biosynthesis using the acetylated, noncyclic route of...; Region: AAK_NAGK-NC; cd04249 1045856013944 nucleotide binding site [chemical binding]; other site 1045856013945 N-acetyl-L-glutamate binding site [chemical binding]; other site 1045856013946 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 1045856013947 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1045856013948 acetylornithine deacetylase; Provisional; Region: PRK05111 1045856013949 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 1045856013950 metal binding site [ion binding]; metal-binding site 1045856013951 putative dimer interface [polypeptide binding]; other site 1045856013952 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 1045856013953 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 1045856013954 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1045856013955 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1045856013956 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 1045856013957 active site 1045856013958 intersubunit interactions; other site 1045856013959 catalytic residue [active] 1045856013960 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 1045856013961 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 1045856013962 dimer interface [polypeptide binding]; other site 1045856013963 active site 1045856013964 metal binding site [ion binding]; metal-binding site 1045856013965 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 1045856013966 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 1045856013967 heme binding site [chemical binding]; other site 1045856013968 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 1045856013969 heme binding site [chemical binding]; other site 1045856013970 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 1045856013971 FAD binding site [chemical binding]; other site 1045856013972 bifunctional aspartate kinase II/homoserine dehydrogenase II; Provisional; Region: metL; PRK09466 1045856013973 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 1045856013974 putative catalytic residues [active] 1045856013975 putative nucleotide binding site [chemical binding]; other site 1045856013976 putative aspartate binding site [chemical binding]; other site 1045856013977 ACT domains C-terminal to the catalytic domain of aspartokinase (AK; 4-L-aspartate-4-phosphotransferase); Region: ACT_AK-like_2; cd04892 1045856013978 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1045856013979 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1045856013980 cystathionine gamma-synthase; Provisional; Region: PRK08045 1045856013981 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1045856013982 homodimer interface [polypeptide binding]; other site 1045856013983 substrate-cofactor binding pocket; other site 1045856013984 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1045856013985 catalytic residue [active] 1045856013986 Met Repressor, MetJ. MetJ is a bacterial regulatory protein that uses S-adenosylmethionine (SAM) as a corepressor to regulate the production of Methionine. MetJ binds arrays of two to five adjacent copies of an eight base-pair 'metbox'...; Region: Met_repressor_MetJ; cd00490 1045856013987 dimerization interface [polypeptide binding]; other site 1045856013988 DNA binding site [nucleotide binding] 1045856013989 corepressor binding sites; other site 1045856013990 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 1045856013991 primosome assembly protein PriA; Validated; Region: PRK05580 1045856013992 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1045856013993 ATP binding site [chemical binding]; other site 1045856013994 putative Mg++ binding site [ion binding]; other site 1045856013995 helicase superfamily c-terminal domain; Region: HELICc; smart00490 1045856013996 ATP-binding site [chemical binding]; other site 1045856013997 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1045856013998 DNA binding site [nucleotide binding] 1045856013999 DNA-binding transcriptional regulator CytR; Provisional; Region: PRK11041 1045856014000 domain linker motif; other site 1045856014001 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 1045856014002 dimerization interface [polypeptide binding]; other site 1045856014003 ligand binding site [chemical binding]; other site 1045856014004 essential cell division protein FtsN; Provisional; Region: PRK10927 1045856014005 cell division protein FtsN; Provisional; Region: PRK12757 1045856014006 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 1045856014007 active site 1045856014008 HslU subunit interaction site [polypeptide binding]; other site 1045856014009 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 1045856014010 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1045856014011 Walker A motif; other site 1045856014012 ATP binding site [chemical binding]; other site 1045856014013 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 1045856014014 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1045856014015 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Region: menA; TIGR00751 1045856014016 UbiA prenyltransferase family; Region: UbiA; pfam01040 1045856014017 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 1045856014018 septal ring assembly protein ZapB; Provisional; Region: PRK15422 1045856014019 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 1045856014020 amphipathic channel; other site 1045856014021 Asn-Pro-Ala signature motifs; other site 1045856014022 glycerol kinase; Provisional; Region: glpK; PRK00047 1045856014023 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 1045856014024 N- and C-terminal domain interface [polypeptide binding]; other site 1045856014025 active site 1045856014026 MgATP binding site [chemical binding]; other site 1045856014027 catalytic site [active] 1045856014028 metal binding site [ion binding]; metal-binding site 1045856014029 glycerol binding site [chemical binding]; other site 1045856014030 homotetramer interface [polypeptide binding]; other site 1045856014031 homodimer interface [polypeptide binding]; other site 1045856014032 FBP binding site [chemical binding]; other site 1045856014033 protein IIAGlc interface [polypeptide binding]; other site 1045856014034 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 1045856014035 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 1045856014036 putative active site [active] 1045856014037 ferredoxin-NADP reductase; Provisional; Region: PRK10926 1045856014038 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 1045856014039 FAD binding pocket [chemical binding]; other site 1045856014040 FAD binding motif [chemical binding]; other site 1045856014041 phosphate binding motif [ion binding]; other site 1045856014042 beta-alpha-beta structure motif; other site 1045856014043 NAD binding pocket [chemical binding]; other site 1045856014044 Predicted membrane protein [Function unknown]; Region: COG3152 1045856014045 Protein of unknown function (DUF1454); Region: DUF1454; pfam07305 1045856014046 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1045856014047 triosephosphate isomerase; Provisional; Region: PRK14567 1045856014048 substrate binding site [chemical binding]; other site 1045856014049 dimer interface [polypeptide binding]; other site 1045856014050 catalytic triad [active] 1045856014051 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1045856014052 transmembrane helices; other site 1045856014053 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1045856014054 CDP-diacylglycerol pyrophosphatase; Provisional; Region: PRK05471 1045856014055 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1045856014056 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1045856014057 substrate binding pocket [chemical binding]; other site 1045856014058 membrane-bound complex binding site; other site 1045856014059 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 1045856014060 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 1045856014061 active site 1045856014062 ADP/pyrophosphate binding site [chemical binding]; other site 1045856014063 dimerization interface [polypeptide binding]; other site 1045856014064 allosteric effector site; other site 1045856014065 fructose-1,6-bisphosphate binding site; other site 1045856014066 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1045856014067 ferrous iron efflux protein F; Reviewed; Region: fieF; PRK09509 1045856014068 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 1045856014069 dimer interface [polypeptide binding]; other site 1045856014070 DNA-binding transcriptional regulator CpxR; Provisional; Region: PRK10955 1045856014071 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1045856014072 active site 1045856014073 intermolecular recognition site; other site 1045856014074 dimerization interface [polypeptide binding]; other site 1045856014075 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1045856014076 DNA binding site [nucleotide binding] 1045856014077 two-component sensor protein; Provisional; Region: cpxA; PRK09470 1045856014078 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1045856014079 dimerization interface [polypeptide binding]; other site 1045856014080 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1045856014081 dimer interface [polypeptide binding]; other site 1045856014082 phosphorylation site [posttranslational modification] 1045856014083 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1045856014084 ATP binding site [chemical binding]; other site 1045856014085 Mg2+ binding site [ion binding]; other site 1045856014086 G-X-G motif; other site 1045856014087 6-N-hydroxylaminopurine resistance protein; Provisional; Region: PRK11536 1045856014088 MOSC domain; Region: MOSC; pfam03473 1045856014089 3-alpha domain; Region: 3-alpha; pfam03475 1045856014090 superoxide dismutase; Provisional; Region: PRK10925 1045856014091 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1045856014092 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1045856014093 L-rhamnose-proton symport protein (RhaT); Region: RhaT; cl05728 1045856014094 RhaT L-rhamnose-proton symporter family protein; Region: RhaT; TIGR00776 1045856014095 transcriptional activator RhaR; Provisional; Region: PRK13502 1045856014096 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1045856014097 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1045856014098 transcriptional activator RhaS; Provisional; Region: PRK13503 1045856014099 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1045856014100 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1045856014101 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1045856014102 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 1045856014103 N- and C-terminal domain interface [polypeptide binding]; other site 1045856014104 active site 1045856014105 putative catalytic site [active] 1045856014106 metal binding site [ion binding]; metal-binding site 1045856014107 ATP binding site [chemical binding]; other site 1045856014108 rhamnulokinase; Provisional; Region: rhaB; PRK10640 1045856014109 carbohydrate binding site [chemical binding]; other site 1045856014110 L-rhamnose isomerase; Provisional; Region: PRK01076 1045856014111 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 1045856014112 intersubunit interface [polypeptide binding]; other site 1045856014113 active site 1045856014114 Zn2+ binding site [ion binding]; other site 1045856014115 L-rhamnose 1-epimerase; Region: YiiL_rotase; TIGR02625 1045856014116 galactoside permease; Reviewed; Region: lacY; PRK09528 1045856014117 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1045856014118 putative substrate translocation pore; other site 1045856014119 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 1045856014120 Melibiase; Region: Melibiase; pfam02065 1045856014121 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1045856014122 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1045856014123 DNA binding site [nucleotide binding] 1045856014124 domain linker motif; other site 1045856014125 Ligand-binding domain of DNA transcription repressors specific for raffinose (RafR) and alpha-glucosides (AglR) which are members of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AglR_RafR_like; cd06271 1045856014126 ligand binding site [chemical binding]; other site 1045856014127 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1045856014128 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1045856014129 non-specific DNA binding site [nucleotide binding]; other site 1045856014130 salt bridge; other site 1045856014131 sequence-specific DNA binding site [nucleotide binding]; other site 1045856014132 Cupin domain; Region: Cupin_2; cl17218 1045856014133 AzlC protein; Region: AzlC; cl00570 1045856014134 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 1045856014135 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 1045856014136 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1045856014137 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1045856014138 molybdopterin cofactor binding site; other site 1045856014139 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 1045856014140 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 1045856014141 molybdopterin cofactor binding site; other site 1045856014142 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 1045856014143 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 1045856014144 formate dehydrogenase-O subunit gamma; Provisional; Region: PRK10639 1045856014145 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 1045856014146 formate dehydrogenase accessory protein FdhE; Provisional; Region: PRK03564 1045856014147 formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562 1045856014148 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1045856014149 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1045856014150 substrate binding pocket [chemical binding]; other site 1045856014151 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1045856014152 Coenzyme A binding pocket [chemical binding]; other site 1045856014153 Putative thioesterase (yiiD_Cterm); Region: YiiD_Cterm; pfam09500 1045856014154 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 1045856014155 putative active site [active] 1045856014156 dimerization interface [polypeptide binding]; other site 1045856014157 putative tRNAtyr binding site [nucleotide binding]; other site 1045856014158 hypothetical protein; Reviewed; Region: PRK01637 1045856014159 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 1045856014160 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1045856014161 motif II; other site 1045856014162 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1045856014163 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1045856014164 DNA-binding site [nucleotide binding]; DNA binding site 1045856014165 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1045856014166 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1045856014167 Ribokinase-like subgroup B. Found in bacteria and plants, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_B; cd01945 1045856014168 substrate binding site [chemical binding]; other site 1045856014169 ATP binding site [chemical binding]; other site 1045856014170 NADH-dependent gamma-hydroxybutyrate dehydrogenase; Provisional; Region: PRK15461 1045856014171 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1045856014172 Class I aldolases; Region: Aldolase_Class_I; cl17187 1045856014173 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cd00249 1045856014174 dimerization interface [polypeptide binding]; other site 1045856014175 putative active cleft [active] 1045856014176 alpha-glucosidase; Provisional; Region: PRK10426 1045856014177 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 1045856014178 YihQ is a bacterial alpha-glucosidase with a conserved glycosyl hydrolase family 31 (GH31) domain that catalyzes the release of an alpha-glucosyl residue from the non-reducing end of alpha-glucoside substrates such as alpha-glucosyl fluoride. Orthologs...; Region: GH31_glucosidase_YihQ; cd06594 1045856014179 putative active site [active] 1045856014180 putative catalytic site [active] 1045856014181 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 1045856014182 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 1045856014183 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 1045856014184 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1045856014185 putative substrate translocation pore; other site 1045856014186 outer membrane porin L; Provisional; Region: ompL; PRK09980 1045856014187 GTP-binding protein; Provisional; Region: PRK10218 1045856014188 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 1045856014189 G1 box; other site 1045856014190 putative GEF interaction site [polypeptide binding]; other site 1045856014191 GTP/Mg2+ binding site [chemical binding]; other site 1045856014192 Switch I region; other site 1045856014193 G2 box; other site 1045856014194 G3 box; other site 1045856014195 Switch II region; other site 1045856014196 G4 box; other site 1045856014197 G5 box; other site 1045856014198 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1045856014199 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1045856014200 glutamine synthetase; Provisional; Region: glnA; PRK09469 1045856014201 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1045856014202 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1045856014203 nitrogen regulation protein NR(II); Provisional; Region: glnL; PRK11073 1045856014204 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1045856014205 putative active site [active] 1045856014206 heme pocket [chemical binding]; other site 1045856014207 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1045856014208 dimer interface [polypeptide binding]; other site 1045856014209 phosphorylation site [posttranslational modification] 1045856014210 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1045856014211 ATP binding site [chemical binding]; other site 1045856014212 Mg2+ binding site [ion binding]; other site 1045856014213 G-X-G motif; other site 1045856014214 nitrogen regulation protein NR(I); Provisional; Region: glnG; PRK10923 1045856014215 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1045856014216 active site 1045856014217 phosphorylation site [posttranslational modification] 1045856014218 intermolecular recognition site; other site 1045856014219 dimerization interface [polypeptide binding]; other site 1045856014220 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1045856014221 Walker A motif; other site 1045856014222 ATP binding site [chemical binding]; other site 1045856014223 Walker B motif; other site 1045856014224 arginine finger; other site 1045856014225 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1045856014226 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 1045856014227 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1045856014228 FeS/SAM binding site; other site 1045856014229 HemN C-terminal domain; Region: HemN_C; pfam06969 1045856014230 Der GTPase activator; Provisional; Region: PRK05244 1045856014231 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 1045856014232 G1 box; other site 1045856014233 GTP/Mg2+ binding site [chemical binding]; other site 1045856014234 Switch I region; other site 1045856014235 G2 box; other site 1045856014236 G3 box; other site 1045856014237 Switch II region; other site 1045856014238 G4 box; other site 1045856014239 G5 box; other site 1045856014240 DNA polymerase I; Provisional; Region: PRK05755 1045856014241 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1045856014242 active site 1045856014243 metal binding site 1 [ion binding]; metal-binding site 1045856014244 putative 5' ssDNA interaction site; other site 1045856014245 metal binding site 3; metal-binding site 1045856014246 metal binding site 2 [ion binding]; metal-binding site 1045856014247 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1045856014248 putative DNA binding site [nucleotide binding]; other site 1045856014249 putative metal binding site [ion binding]; other site 1045856014250 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 1045856014251 active site 1045856014252 catalytic site [active] 1045856014253 substrate binding site [chemical binding]; other site 1045856014254 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1045856014255 active site 1045856014256 DNA binding site [nucleotide binding] 1045856014257 catalytic site [active] 1045856014258 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1045856014259 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990 1045856014260 putative acyl-acceptor binding pocket; other site 1045856014261 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 1045856014262 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1045856014263 catalytic residues [active] 1045856014264 hinge region; other site 1045856014265 alpha helical domain; other site 1045856014266 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 1045856014267 serine/threonine protein kinase; Provisional; Region: PRK11768 1045856014268 Protein of unknown function (DUF1040); Region: DUF1040; pfam06288 1045856014269 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 1045856014270 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 1045856014271 GTP binding site; other site 1045856014272 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 1045856014273 Walker A motif; other site 1045856014274 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1045856014275 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1045856014276 DNA-binding site [nucleotide binding]; DNA binding site 1045856014277 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1045856014278 putative transporter; Provisional; Region: PRK10504 1045856014279 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1045856014280 putative substrate translocation pore; other site 1045856014281 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1045856014282 transcriptional repressor RbsR; Provisional; Region: PRK10423 1045856014283 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1045856014284 DNA binding site [nucleotide binding] 1045856014285 domain linker motif; other site 1045856014286 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 1045856014287 dimerization interface [polypeptide binding]; other site 1045856014288 ligand binding site [chemical binding]; other site 1045856014289 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1045856014290 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1045856014291 substrate binding site [chemical binding]; other site 1045856014292 dimer interface [polypeptide binding]; other site 1045856014293 ATP binding site [chemical binding]; other site 1045856014294 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 1045856014295 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 1045856014296 ligand binding site [chemical binding]; other site 1045856014297 dimerization interface [polypeptide binding]; other site 1045856014298 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1045856014299 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1045856014300 TM-ABC transporter signature motif; other site 1045856014301 D-ribose transporter ATP binding protein; Provisional; Region: PRK10762 1045856014302 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1045856014303 Walker A/P-loop; other site 1045856014304 ATP binding site [chemical binding]; other site 1045856014305 Q-loop/lid; other site 1045856014306 ABC transporter signature motif; other site 1045856014307 Walker B; other site 1045856014308 D-loop; other site 1045856014309 H-loop/switch region; other site 1045856014310 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1045856014311 D-ribose pyranase; Provisional; Region: PRK11797 1045856014312 potassium transport protein Kup; Provisional; Region: trkD; PRK10745 1045856014313 potassium uptake protein; Region: kup; TIGR00794 1045856014314 regulatory ATPase RavA; Provisional; Region: PRK13531 1045856014315 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1045856014316 Walker A motif; other site 1045856014317 ATP binding site [chemical binding]; other site 1045856014318 Walker B motif; other site 1045856014319 arginine finger; other site 1045856014320 Protein of unknown function (DUF3763); Region: DUF3763; pfam12592 1045856014321 hypothetical protein; Provisional; Region: yieM; PRK10997 1045856014322 Protein of unknown function (DUF3160); Region: DUF3160; pfam11369 1045856014323 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 1045856014324 metal ion-dependent adhesion site (MIDAS); other site 1045856014325 Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia. AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645 1045856014326 dimer interface [polypeptide binding]; other site 1045856014327 active site 1045856014328 DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179 1045856014329 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1045856014330 putative DNA binding site [nucleotide binding]; other site 1045856014331 putative Zn2+ binding site [ion binding]; other site 1045856014332 AsnC family; Region: AsnC_trans_reg; pfam01037 1045856014333 FMN-binding protein MioC; Provisional; Region: PRK09004 1045856014334 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 1045856014335 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 1045856014336 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 1045856014337 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 1045856014338 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1045856014339 S-adenosylmethionine binding site [chemical binding]; other site 1045856014340 F0F1 ATP synthase subunit I; Validated; Region: PRK08049 1045856014341 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 1045856014342 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 1045856014343 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 1045856014344 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 1045856014345 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 1045856014346 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 1045856014347 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 1045856014348 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1045856014349 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1045856014350 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 1045856014351 beta subunit interaction interface [polypeptide binding]; other site 1045856014352 Walker A motif; other site 1045856014353 ATP binding site [chemical binding]; other site 1045856014354 Walker B motif; other site 1045856014355 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1045856014356 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1045856014357 core domain interface [polypeptide binding]; other site 1045856014358 delta subunit interface [polypeptide binding]; other site 1045856014359 epsilon subunit interface [polypeptide binding]; other site 1045856014360 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1045856014361 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1045856014362 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1045856014363 alpha subunit interaction interface [polypeptide binding]; other site 1045856014364 Walker A motif; other site 1045856014365 ATP binding site [chemical binding]; other site 1045856014366 Walker B motif; other site 1045856014367 inhibitor binding site; inhibition site 1045856014368 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1045856014369 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 1045856014370 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1045856014371 gamma subunit interface [polypeptide binding]; other site 1045856014372 epsilon subunit interface [polypeptide binding]; other site 1045856014373 LBP interface [polypeptide binding]; other site 1045856014374 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK09451 1045856014375 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 1045856014376 Substrate binding site; other site 1045856014377 Mg++ binding site; other site 1045856014378 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 1045856014379 active site 1045856014380 substrate binding site [chemical binding]; other site 1045856014381 CoA binding site [chemical binding]; other site 1045856014382 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1045856014383 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1045856014384 glutaminase active site [active] 1045856014385 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1045856014386 dimer interface [polypeptide binding]; other site 1045856014387 active site 1045856014388 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1045856014389 dimer interface [polypeptide binding]; other site 1045856014390 active site 1045856014391 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1045856014392 phosphate transporter permease subunit PstC; Provisional; Region: pstC; PRK11275 1045856014393 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1045856014394 dimer interface [polypeptide binding]; other site 1045856014395 conserved gate region; other site 1045856014396 putative PBP binding loops; other site 1045856014397 ABC-ATPase subunit interface; other site 1045856014398 phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268 1045856014399 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1045856014400 dimer interface [polypeptide binding]; other site 1045856014401 conserved gate region; other site 1045856014402 putative PBP binding loops; other site 1045856014403 ABC-ATPase subunit interface; other site 1045856014404 phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744 1045856014405 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1045856014406 Walker A/P-loop; other site 1045856014407 ATP binding site [chemical binding]; other site 1045856014408 Q-loop/lid; other site 1045856014409 ABC transporter signature motif; other site 1045856014410 Walker B; other site 1045856014411 D-loop; other site 1045856014412 H-loop/switch region; other site 1045856014413 transcriptional regulator PhoU; Provisional; Region: PRK11115 1045856014414 PhoU domain; Region: PhoU; pfam01895 1045856014415 PhoU domain; Region: PhoU; pfam01895 1045856014416 6-phosphogluconate phosphatase; Provisional; Region: PRK10563 1045856014417 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1045856014418 motif II; other site 1045856014419 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1045856014420 Predicted flavoprotein [General function prediction only]; Region: COG0431 1045856014421 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1045856014422 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 1045856014423 DNA-binding transcriptional regulator YidZ; Provisional; Region: PRK10216 1045856014424 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1045856014425 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 1045856014426 substrate binding pocket [chemical binding]; other site 1045856014427 dimerization interface [polypeptide binding]; other site 1045856014428 multidrug efflux system protein MdtL; Provisional; Region: PRK10473 1045856014429 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1045856014430 putative substrate translocation pore; other site 1045856014431 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 1045856014432 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 1045856014433 trmE is a tRNA modification GTPase; Region: trmE; cd04164 1045856014434 G1 box; other site 1045856014435 GTP/Mg2+ binding site [chemical binding]; other site 1045856014436 Switch I region; other site 1045856014437 G2 box; other site 1045856014438 Switch II region; other site 1045856014439 G3 box; other site 1045856014440 G4 box; other site 1045856014441 G5 box; other site 1045856014442 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 1045856014443 membrane protein insertase; Provisional; Region: PRK01318 1045856014444 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 1045856014445 ribonuclease P; Reviewed; Region: rnpA; PRK01732 1045856014446 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 1045856014447 IncFII RepA protein family; Region: IncFII_repA; cl11495 1045856014448 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453 1045856014449 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 1045856014450 Phage-related protein [Function unknown]; Region: COG4695; cl01923 1045856014451 Domain of unknown function (DUF4145); Region: DUF4145; pfam13643 1045856014452 Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973 1045856014453 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1045856014454 active site 1045856014455 DNA binding site [nucleotide binding] 1045856014456 Int/Topo IB signature motif; other site 1045856014457 Toxin YafO, type II toxin-antitoxin system; Region: YafO_toxin; pfam13957 1045856014458 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 1045856014459 DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023 1045856014460 catalytic residues [active] 1045856014461 DNA helicase TraI; Region: TraI; pfam07057 1045856014462 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 1045856014463 DNA binding site [nucleotide binding] 1045856014464 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 1045856014465 replication protein; Provisional; Region: PRK13742 1045856014466 ParA-like protein; Provisional; Region: PHA02518 1045856014467 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1045856014468 P-loop; other site 1045856014469 Magnesium ion binding site [ion binding]; other site 1045856014470 Phage integrase family; Region: Phage_integrase; pfam00589 1045856014471 active site 1045856014472 DNA binding site [nucleotide binding] 1045856014473 Int/Topo IB signature motif; other site 1045856014474 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1045856014475 Walker A/P-loop; other site 1045856014476 ATP binding site [chemical binding]; other site 1045856014477 Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456 1045856014478 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 1045856014479 oligomeric interface; other site 1045856014480 putative active site [active] 1045856014481 homodimer interface [polypeptide binding]; other site 1045856014482 Protein of unknown function (DUF3644); Region: DUF3644; pfam12358 1045856014483 Restriction endonuclease; Region: Mrr_cat; pfam04471 1045856014484 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1045856014485 dimerization interface [polypeptide binding]; other site 1045856014486 Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456 1045856014487 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1045856014488 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1045856014489 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1045856014490 HlyD family secretion protein; Region: HlyD_3; pfam13437 1045856014491 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1045856014492 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1045856014493 dimer interface [polypeptide binding]; other site 1045856014494 phosphorylation site [posttranslational modification] 1045856014495 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1045856014496 ATP binding site [chemical binding]; other site 1045856014497 Mg2+ binding site [ion binding]; other site 1045856014498 G-X-G motif; other site 1045856014499 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1045856014500 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1045856014501 active site 1045856014502 phosphorylation site [posttranslational modification] 1045856014503 intermolecular recognition site; other site 1045856014504 dimerization interface [polypeptide binding]; other site 1045856014505 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1045856014506 DNA binding site [nucleotide binding] 1045856014507 MltA-interacting protein MipA; Region: MipA; cl01504 1045856014508 OsmC-like protein; Region: OsmC; pfam02566 1045856014509 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1045856014510 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1045856014511 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1045856014512 DNA-binding transcriptional regulator DsdC; Provisional; Region: PRK10086 1045856014513 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1045856014514 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 1045856014515 dimerization interface [polypeptide binding]; other site 1045856014516 substrate binding pocket [chemical binding]; other site 1045856014517 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 1045856014518 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 1045856014519 NAD binding site [chemical binding]; other site 1045856014520 sugar binding site [chemical binding]; other site 1045856014521 divalent metal binding site [ion binding]; other site 1045856014522 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1045856014523 dimer interface [polypeptide binding]; other site 1045856014524 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1045856014525 catalytic residues [active] 1045856014526 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1045856014527 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1045856014528 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1045856014529 substrate binding site [chemical binding]; other site 1045856014530 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1045856014531 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 1045856014532 FMN binding site [chemical binding]; other site 1045856014533 active site 1045856014534 substrate binding site [chemical binding]; other site 1045856014535 catalytic residue [active] 1045856014536 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 1045856014537 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 1045856014538 catalytic residues [active] 1045856014539 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1045856014540 classical (c) SDRs; Region: SDR_c; cd05233 1045856014541 NAD(P) binding site [chemical binding]; other site 1045856014542 active site 1045856014543 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1045856014544 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 1045856014545 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1045856014546 EamA-like transporter family; Region: EamA; pfam00892 1045856014547 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 1045856014548 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1045856014549 Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005 1045856014550 tetramer interface [polypeptide binding]; other site 1045856014551 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1045856014552 active site 1045856014553 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1045856014554 active site 1045856014555 phosphorylation site [posttranslational modification] 1045856014556 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 1045856014557 active site 1045856014558 P-loop; other site 1045856014559 phosphorylation site [posttranslational modification] 1045856014560 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 1045856014561 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 1045856014562 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 1045856014563 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1045856014564 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1045856014565 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1045856014566 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1045856014567 active site 1045856014568 phosphorylation site [posttranslational modification] 1045856014569 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 1045856014570 active site 1045856014571 P-loop; other site 1045856014572 phosphorylation site [posttranslational modification] 1045856014573 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 1045856014574 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 1045856014575 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 1045856014576 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1045856014577 substrate binding site [chemical binding]; other site 1045856014578 hexamer interface [polypeptide binding]; other site 1045856014579 metal binding site [ion binding]; metal-binding site 1045856014580 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1045856014581 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1045856014582 NAD(P) binding site [chemical binding]; other site 1045856014583 active site 1045856014584 Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005 1045856014585 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1045856014586 tetramer interface [polypeptide binding]; other site 1045856014587 active site 1045856014588 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 1045856014589 Uncharacterized protein family (UPF0156); Region: RHH_2; pfam03693 1045856014590 TraX protein; Region: TraX; pfam05857 1045856014591 Protein of unknown function (DUF4225); Region: DUF4225; pfam13988