-- dump date 20140619_073737 -- class Genbank::misc_feature -- table misc_feature_note -- id note 693444000001 DnaA N-terminal domain; Region: DnaA_N; pfam11638 693444000002 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 693444000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693444000004 Walker A motif; other site 693444000005 ATP binding site [chemical binding]; other site 693444000006 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 693444000007 Walker B motif; other site 693444000008 arginine finger; other site 693444000009 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 693444000010 DnaA box-binding interface [nucleotide binding]; other site 693444000011 DNA polymerase III subunit beta; Validated; Region: PRK05643 693444000012 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 693444000013 putative DNA binding surface [nucleotide binding]; other site 693444000014 dimer interface [polypeptide binding]; other site 693444000015 beta-clamp/clamp loader binding surface; other site 693444000016 beta-clamp/translesion DNA polymerase binding surface; other site 693444000017 recF protein; Region: recf; TIGR00611 693444000018 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693444000019 Walker A/P-loop; other site 693444000020 ATP binding site [chemical binding]; other site 693444000021 Q-loop/lid; other site 693444000022 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693444000023 ABC transporter signature motif; other site 693444000024 Walker B; other site 693444000025 D-loop; other site 693444000026 H-loop/switch region; other site 693444000027 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 693444000028 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693444000029 Mg2+ binding site [ion binding]; other site 693444000030 G-X-G motif; other site 693444000031 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 693444000032 anchoring element; other site 693444000033 dimer interface [polypeptide binding]; other site 693444000034 ATP binding site [chemical binding]; other site 693444000035 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 693444000036 active site 693444000037 putative metal-binding site [ion binding]; other site 693444000038 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 693444000039 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 693444000040 PTS system, maltose and glucose-specific IIBC component; Region: PTS-IIBC-malX; TIGR02004 693444000041 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 693444000042 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 693444000043 active site turn [active] 693444000044 phosphorylation site [posttranslational modification] 693444000045 Bacterial protein of unknown function (DUF937); Region: DUF937; cl01528 693444000046 sugar phosphate phosphatase; Provisional; Region: PRK10513 693444000047 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 693444000048 active site 693444000049 motif I; other site 693444000050 motif II; other site 693444000051 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 693444000052 putative oxidoreductase; Provisional; Region: PRK11445 693444000053 Protein of unknown function (DUF3748); Region: DUF3748; pfam12566 693444000054 hypothetical protein; Provisional; Region: PRK11616 693444000055 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 693444000056 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 693444000057 putative dimer interface [polypeptide binding]; other site 693444000058 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 693444000059 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 693444000060 putative dimer interface [polypeptide binding]; other site 693444000061 putative transporter; Validated; Region: PRK03818 693444000062 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 693444000063 TrkA-C domain; Region: TrkA_C; pfam02080 693444000064 TrkA-C domain; Region: TrkA_C; pfam02080 693444000065 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 693444000066 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 693444000067 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 693444000068 DNA-binding site [nucleotide binding]; DNA binding site 693444000069 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 693444000070 PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005 693444000071 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 693444000072 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 693444000073 active site turn [active] 693444000074 phosphorylation site [posttranslational modification] 693444000075 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 693444000076 Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298 693444000077 NAD binding site [chemical binding]; other site 693444000078 sugar binding site [chemical binding]; other site 693444000079 divalent metal binding site [ion binding]; other site 693444000080 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 693444000081 dimer interface [polypeptide binding]; other site 693444000082 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 693444000083 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 693444000084 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 693444000085 putative transporter; Provisional; Region: PRK10484 693444000086 uncharacterized SLC5 subfamily, Escherichia coli YidK-like; solute binding domain; Region: SLC5sbd_YidK; cd10328 693444000087 Na binding site [ion binding]; other site 693444000088 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 693444000089 Sulfatase; Region: Sulfatase; pfam00884 693444000090 Predicted membrane protein [Function unknown]; Region: COG2149 693444000091 Domain of unknown function (DUF202); Region: DUF202; pfam02656 693444000092 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 693444000093 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 693444000094 FeS/SAM binding site; other site 693444000095 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 693444000096 D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine to pyruvate and ammonia. D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447 693444000097 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 693444000098 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 693444000099 catalytic residue [active] 693444000100 multidrug resistance protein D; Provisional; Region: emrD; PRK11652 693444000101 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693444000102 putative substrate translocation pore; other site 693444000103 acetolactate synthase catalytic subunit; Validated; Region: PRK08155 693444000104 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 693444000105 PYR/PP interface [polypeptide binding]; other site 693444000106 dimer interface [polypeptide binding]; other site 693444000107 TPP binding site [chemical binding]; other site 693444000108 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 693444000109 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 693444000110 TPP-binding site [chemical binding]; other site 693444000111 dimer interface [polypeptide binding]; other site 693444000112 Acetolactate synthase, small (regulatory) subunit [Amino acid transport and metabolism]; Region: IlvH; COG0440 693444000113 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 693444000114 putative valine binding site [chemical binding]; other site 693444000115 dimer interface [polypeptide binding]; other site 693444000116 2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140 693444000117 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 693444000118 active site 693444000119 intersubunit interface [polypeptide binding]; other site 693444000120 catalytic residue [active] 693444000121 2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734 693444000122 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 693444000123 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693444000124 D-galactonate transporter; Region: 2A0114; TIGR00893 693444000125 putative substrate translocation pore; other site 693444000126 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 693444000127 galactarate dehydratase; Region: galactar-dH20; TIGR03248 693444000128 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 693444000129 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 693444000130 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 693444000131 inhibitor site; inhibition site 693444000132 active site 693444000133 dimer interface [polypeptide binding]; other site 693444000134 catalytic residue [active] 693444000135 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 693444000136 Transcriptional regulator [Transcription]; Region: IclR; COG1414 693444000137 Bacterial transcriptional regulator; Region: IclR; pfam01614 693444000138 Protein of unknown function (DUF1198); Region: DUF1198; pfam06711 693444000139 ribonucleoside transporter; Reviewed; Region: nepI; PRK10213 693444000140 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693444000141 putative substrate translocation pore; other site 693444000142 EamA-like transporter family; Region: EamA; pfam00892 693444000143 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 693444000144 EamA-like transporter family; Region: EamA; pfam00892 693444000145 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 693444000146 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cl00164 693444000147 active site turn [active] 693444000148 phosphorylation site [posttranslational modification] 693444000149 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 693444000150 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 693444000151 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 693444000152 putative active site [active] 693444000153 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693444000154 putative substrate translocation pore; other site 693444000155 copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837 693444000156 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 693444000157 Protein export membrane protein; Region: SecD_SecF; cl14618 693444000158 multidrug efflux system protein MdtE; Provisional; Region: PRK09859 693444000159 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 693444000160 HlyD family secretion protein; Region: HlyD_3; pfam13437 693444000161 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 693444000162 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 693444000163 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 693444000164 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693444000165 putative substrate translocation pore; other site 693444000166 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 693444000167 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 693444000168 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 693444000169 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 693444000170 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 693444000171 FMN binding site [chemical binding]; other site 693444000172 active site 693444000173 substrate binding site [chemical binding]; other site 693444000174 catalytic residue [active] 693444000175 cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705 693444000176 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 693444000177 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693444000178 S-adenosylmethionine binding site [chemical binding]; other site 693444000179 outer membrane porin, OprD family; Region: OprD; pfam03573 693444000180 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 693444000181 putative transporter; Provisional; Region: PRK11462 693444000182 putative alpha-glucosidase; Provisional; Region: PRK10658 693444000183 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 693444000184 YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593 693444000185 active site 693444000186 homotrimer interface [polypeptide binding]; other site 693444000187 catalytic site [active] 693444000188 homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site 693444000189 AsmA family; Region: AsmA; pfam05170 693444000190 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 693444000191 sodium--glutamate symport carrier (gltS); Region: gltS; TIGR00210 693444000192 glycerol kinase; Provisional; Region: glpK; PRK00047 693444000193 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 693444000194 N- and C-terminal domain interface [polypeptide binding]; other site 693444000195 active site 693444000196 MgATP binding site [chemical binding]; other site 693444000197 catalytic site [active] 693444000198 metal binding site [ion binding]; metal-binding site 693444000199 glycerol binding site [chemical binding]; other site 693444000200 homotetramer interface [polypeptide binding]; other site 693444000201 homodimer interface [polypeptide binding]; other site 693444000202 FBP binding site [chemical binding]; other site 693444000203 protein IIAGlc interface [polypeptide binding]; other site 693444000204 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 693444000205 amphipathic channel; other site 693444000206 Asn-Pro-Ala signature motifs; other site 693444000207 septal ring assembly protein ZapB; Provisional; Region: PRK15422 693444000208 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 693444000209 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 693444000210 substrate binding pocket [chemical binding]; other site 693444000211 membrane-bound complex binding site; other site 693444000212 CDP-diacylglycerol pyrophosphatase; Region: CDH; cl00934 693444000213 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 693444000214 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 693444000215 transmembrane helices; other site 693444000216 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 693444000217 triosephosphate isomerase; Provisional; Region: PRK14567 693444000218 substrate binding site [chemical binding]; other site 693444000219 dimer interface [polypeptide binding]; other site 693444000220 catalytic triad [active] 693444000221 Protein of unknown function (DUF1454); Region: DUF1454; pfam07305 693444000222 Predicted membrane protein [Function unknown]; Region: COG3152 693444000223 ferredoxin-NADP reductase; Provisional; Region: PRK10926 693444000224 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 693444000225 FAD binding pocket [chemical binding]; other site 693444000226 FAD binding motif [chemical binding]; other site 693444000227 phosphate binding motif [ion binding]; other site 693444000228 beta-alpha-beta structure motif; other site 693444000229 NAD binding pocket [chemical binding]; other site 693444000230 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 693444000231 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 693444000232 putative active site [active] 693444000233 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 693444000234 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 693444000235 generic binding surface II; other site 693444000236 ssDNA binding site; other site 693444000237 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 693444000238 ATP binding site [chemical binding]; other site 693444000239 putative Mg++ binding site [ion binding]; other site 693444000240 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 693444000241 nucleotide binding region [chemical binding]; other site 693444000242 ATP-binding site [chemical binding]; other site 693444000243 tRNA guanosine-2'-O-methyltransferase; Provisional; Region: PRK11081 693444000244 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 693444000245 SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105 693444000246 bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092 693444000247 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 693444000248 Zn2+ binding site [ion binding]; other site 693444000249 Mg2+ binding site [ion binding]; other site 693444000250 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 693444000251 synthetase active site [active] 693444000252 NTP binding site [chemical binding]; other site 693444000253 metal binding site [ion binding]; metal-binding site 693444000254 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 693444000255 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 693444000256 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 693444000257 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 693444000258 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 693444000259 catalytic site [active] 693444000260 G-X2-G-X-G-K; other site 693444000261 NAD-dependent DNA ligase LigB; Reviewed; Region: ligB; PRK08097 693444000262 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295 693444000263 nucleotide binding pocket [chemical binding]; other site 693444000264 K-X-D-G motif; other site 693444000265 catalytic site [active] 693444000266 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 693444000267 Predicted membrane protein [Function unknown]; Region: COG2860 693444000268 UPF0126 domain; Region: UPF0126; pfam03458 693444000269 UPF0126 domain; Region: UPF0126; pfam03458 693444000270 hypothetical protein; Provisional; Region: PRK11820 693444000271 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 693444000272 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 693444000273 ribonuclease PH; Reviewed; Region: rph; PRK00173 693444000274 Ribonuclease PH; Region: RNase_PH_bact; cd11362 693444000275 hexamer interface [polypeptide binding]; other site 693444000276 active site 693444000277 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 693444000278 active site 693444000279 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 693444000280 RT_Bac_retron_II: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_II; cd03487 693444000281 putative active site [active] 693444000282 putative NTP binding site [chemical binding]; other site 693444000283 putative nucleic acid binding site [nucleotide binding]; other site 693444000284 division inhibitor protein; Provisional; Region: slmA; PRK09480 693444000285 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 693444000286 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 693444000287 trimer interface [polypeptide binding]; other site 693444000288 active site 693444000289 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 693444000290 Flavoprotein; Region: Flavoprotein; pfam02441 693444000291 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 693444000292 hypothetical protein; Reviewed; Region: PRK00024 693444000293 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 693444000294 MPN+ (JAMM) motif; other site 693444000295 Zinc-binding site [ion binding]; other site 693444000296 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 693444000297 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 693444000298 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 693444000299 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 693444000300 DNA binding site [nucleotide binding] 693444000301 catalytic residue [active] 693444000302 H2TH interface [polypeptide binding]; other site 693444000303 putative catalytic residues [active] 693444000304 turnover-facilitating residue; other site 693444000305 intercalation triad [nucleotide binding]; other site 693444000306 8OG recognition residue [nucleotide binding]; other site 693444000307 putative reading head residues; other site 693444000308 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 693444000309 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 693444000310 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 693444000311 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 693444000312 active site 693444000313 (T/H)XGH motif; other site 693444000314 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 693444000315 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 693444000316 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 693444000317 lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK10422 693444000318 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 693444000319 putative active site [active] 693444000320 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 693444000321 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 693444000322 lipopolysaccharide core heptose(I) kinase RfaP; Provisional; Region: PRK15123 693444000323 lipopolysaccharide 1,3-galactosyltransferase; Provisional; Region: PRK15171 693444000324 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 693444000325 Ligand binding site; other site 693444000326 metal-binding site 693444000327 Glycosyl transferase family 8 C-terminal; Region: Glyco_transf_8C; pfam08437 693444000328 lipopolysaccharide 1,3-galactosyltransferase; Provisional; Region: PRK15171 693444000329 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 693444000330 Ligand binding site; other site 693444000331 metal-binding site 693444000332 Glycosyl transferase family 8 C-terminal; Region: Glyco_transf_8C; pfam08437 693444000333 Lipopolysaccharide core biosynthesis protein (WaaY); Region: WaaY; cl17526 693444000334 lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK09822 693444000335 lipopolysaccharide 1,2-N-acetylglucosaminetransferase; Provisional; Region: PRK15484 693444000336 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 693444000337 O-Antigen ligase; Region: Wzy_C; cl04850 693444000338 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 693444000339 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 693444000340 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 693444000341 putative active site [active] 693444000342 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 693444000343 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 693444000344 putative active site [active] 693444000345 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 693444000346 ADP-L-glycero-D-mannoheptose-6-epimerase; Provisional; Region: rfaD; PRK11150 693444000347 NADP binding site [chemical binding]; other site 693444000348 homopentamer interface [polypeptide binding]; other site 693444000349 substrate binding site [chemical binding]; other site 693444000350 active site 693444000351 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 693444000352 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 693444000353 substrate-cofactor binding pocket; other site 693444000354 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693444000355 catalytic residue [active] 693444000356 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 693444000357 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 693444000358 NAD(P) binding site [chemical binding]; other site 693444000359 putative glycosyl transferase; Provisional; Region: PRK10073 693444000360 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 693444000361 active site 693444000362 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 693444000363 NodB motif; other site 693444000364 putative active site [active] 693444000365 putative catalytic site [active] 693444000366 Zn binding site [ion binding]; other site 693444000367 AmiB activator; Provisional; Region: PRK11637 693444000368 Peptidase family M23; Region: Peptidase_M23; pfam01551 693444000369 phosphoglyceromutase; Provisional; Region: PRK05434 693444000370 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 693444000371 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 693444000372 active site residue [active] 693444000373 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 693444000374 GSH binding site [chemical binding]; other site 693444000375 catalytic residues [active] 693444000376 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557 693444000377 SecA binding site; other site 693444000378 Preprotein binding site; other site 693444000379 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 693444000380 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 693444000381 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 693444000382 serine acetyltransferase; Provisional; Region: cysE; PRK11132 693444000383 Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426 693444000384 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 693444000385 trimer interface [polypeptide binding]; other site 693444000386 active site 693444000387 substrate binding site [chemical binding]; other site 693444000388 CoA binding site [chemical binding]; other site 693444000389 putative rRNA methylase; Provisional; Region: PRK10358 693444000390 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 693444000391 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 693444000392 active site 693444000393 substrate binding site [chemical binding]; other site 693444000394 FMN binding site [chemical binding]; other site 693444000395 putative catalytic residues [active] 693444000396 DNA-binding transcriptional repressor LldR; Provisional; Region: PRK10421 693444000397 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 693444000398 DNA-binding site [nucleotide binding]; DNA binding site 693444000399 FCD domain; Region: FCD; pfam07729 693444000400 L-lactate permease; Provisional; Region: PRK10420 693444000401 glycolate transporter; Provisional; Region: PRK09695 693444000402 Glycogen synthesis protein; Region: GlgS; cl11663 693444000403 Transcriptional regulator [Transcription]; Region: MtlR; COG3722 693444000404 mannitol repressor protein; Provisional; Region: mtlR; PRK11001 693444000405 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 693444000406 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 693444000407 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 693444000408 PTS system mannitol-specific transporter subunit IICBA; Provisional; Region: PRK15083 693444000409 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 693444000410 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 693444000411 active site 693444000412 P-loop; other site 693444000413 phosphorylation site [posttranslational modification] 693444000414 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 693444000415 active site 693444000416 phosphorylation site [posttranslational modification] 693444000417 Protein of unknown function (DUF3302); Region: DUF3302; pfam11742 693444000418 Polo-box domain (PBD), a C-terminal tandemly repeated region of polo-like kinases; Region: POLO_box; cl02916 693444000419 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 693444000420 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 693444000421 HlyD family secretion protein; Region: HlyD_3; pfam13437 693444000422 putative glutathione S-transferase; Provisional; Region: PRK10357 693444000423 GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049 693444000424 putative C-terminal domain interface [polypeptide binding]; other site 693444000425 putative GSH binding site (G-site) [chemical binding]; other site 693444000426 putative dimer interface [polypeptide binding]; other site 693444000427 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 693444000428 dimer interface [polypeptide binding]; other site 693444000429 N-terminal domain interface [polypeptide binding]; other site 693444000430 putative substrate binding pocket (H-site) [chemical binding]; other site 693444000431 selenocysteine synthase; Provisional; Region: PRK04311 693444000432 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390 693444000433 Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921 693444000434 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 693444000435 catalytic residue [active] 693444000436 selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512 693444000437 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 693444000438 G1 box; other site 693444000439 putative GEF interaction site [polypeptide binding]; other site 693444000440 GTP/Mg2+ binding site [chemical binding]; other site 693444000441 Switch I region; other site 693444000442 G2 box; other site 693444000443 G3 box; other site 693444000444 Switch II region; other site 693444000445 G4 box; other site 693444000446 G5 box; other site 693444000447 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 693444000448 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094 693444000449 Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106 693444000450 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 693444000451 putative alcohol dehydrogenase; Provisional; Region: PRK09860 693444000452 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 693444000453 dimer interface [polypeptide binding]; other site 693444000454 active site 693444000455 metal binding site [ion binding]; metal-binding site 693444000456 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 693444000457 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 693444000458 NAD(P) binding site [chemical binding]; other site 693444000459 catalytic residues [active] 693444000460 Protein of unknown function (DUF3302); Region: DUF3302; pfam11742 693444000461 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 693444000462 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 693444000463 HlyD family secretion protein; Region: HlyD_3; pfam13437 693444000464 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693444000465 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693444000466 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 693444000467 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 693444000468 YcfA-like protein; Region: YcfA; pfam07927 693444000469 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 693444000470 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 693444000471 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 693444000472 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 693444000473 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 693444000474 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 693444000475 Helix-turn-helix domain; Region: HTH_18; pfam12833 693444000476 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 693444000477 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 693444000478 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 693444000479 intersubunit interface [polypeptide binding]; other site 693444000480 active site 693444000481 Zn2+ binding site [ion binding]; other site 693444000482 putative L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13210 693444000483 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 693444000484 AP (apurinic/apyrimidinic) site pocket; other site 693444000485 DNA interaction; other site 693444000486 Metal-binding active site; metal-binding site 693444000487 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 693444000488 active site 693444000489 dimer interface [polypeptide binding]; other site 693444000490 magnesium binding site [ion binding]; other site 693444000491 L-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802 693444000492 putative N- and C-terminal domain interface [polypeptide binding]; other site 693444000493 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 693444000494 putative active site [active] 693444000495 MgATP binding site [chemical binding]; other site 693444000496 catalytic site [active] 693444000497 metal binding site [ion binding]; metal-binding site 693444000498 putative xylulose binding site [chemical binding]; other site 693444000499 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693444000500 D-galactonate transporter; Region: 2A0114; TIGR00893 693444000501 putative substrate translocation pore; other site 693444000502 Domain of unknown function (DUF386); Region: DUF386; pfam04074 693444000503 2,3-diketo-L-gulonate reductase; Provisional; Region: PRK13260 693444000504 Transcriptional regulator [Transcription]; Region: IclR; COG1414 693444000505 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 693444000506 Bacterial transcriptional regulator; Region: IclR; pfam01614 693444000507 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 693444000508 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 693444000509 valine--pyruvate transaminase; Provisional; Region: avtA; PRK09440 693444000510 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 693444000511 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693444000512 homodimer interface [polypeptide binding]; other site 693444000513 catalytic residue [active] 693444000514 alpha-amylase; Reviewed; Region: malS; PRK09505 693444000515 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 693444000516 active site 693444000517 catalytic site [active] 693444000518 hypothetical protein; Provisional; Region: PRK10356 693444000519 Uncharacterized FlgJ-related protein [General function prediction only]; Region: Bax; COG2992 693444000520 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693444000521 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693444000522 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 693444000523 putative effector binding pocket; other site 693444000524 dimerization interface [polypeptide binding]; other site 693444000525 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 693444000526 Ligand-binding domain of DNA transcription repressor specific for xylose (XylR); Region: PBP1_XylR; cd01543 693444000527 putative dimerization interface [polypeptide binding]; other site 693444000528 Transcriptional regulators [Transcription]; Region: PurR; COG1609 693444000529 putative ligand binding site [chemical binding]; other site 693444000530 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 693444000531 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 693444000532 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 693444000533 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 693444000534 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 693444000535 TM-ABC transporter signature motif; other site 693444000536 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 693444000537 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 693444000538 Walker A/P-loop; other site 693444000539 ATP binding site [chemical binding]; other site 693444000540 Q-loop/lid; other site 693444000541 ABC transporter signature motif; other site 693444000542 Walker B; other site 693444000543 D-loop; other site 693444000544 H-loop/switch region; other site 693444000545 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 693444000546 D-xylose transporter subunit XylF; Provisional; Region: xylF; PRK10355 693444000547 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 693444000548 putative ligand binding site [chemical binding]; other site 693444000549 xylose isomerase; Provisional; Region: PRK05474 693444000550 xylose isomerase; Region: xylose_isom_A; TIGR02630 693444000551 xylulokinase; Provisional; Region: PRK15027 693444000552 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 693444000553 N- and C-terminal domain interface [polypeptide binding]; other site 693444000554 active site 693444000555 MgATP binding site [chemical binding]; other site 693444000556 catalytic site [active] 693444000557 metal binding site [ion binding]; metal-binding site 693444000558 xylulose binding site [chemical binding]; other site 693444000559 homodimer interface [polypeptide binding]; other site 693444000560 hypothetical protein; Provisional; Region: PRK11403 693444000561 yiaA/B two helix domain; Region: YiaAB; cl01759 693444000562 yiaA/B two helix domain; Region: YiaAB; cl01759 693444000563 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 693444000564 Acyltransferase family; Region: Acyl_transf_3; pfam01757 693444000565 YsaB-like lipoprotein; Region: YsaB; pfam13983 693444000566 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 693444000567 dimer interface [polypeptide binding]; other site 693444000568 motif 1; other site 693444000569 active site 693444000570 motif 2; other site 693444000571 motif 3; other site 693444000572 glycyl-tRNA synthetase, tetrameric type, beta subunit; Region: glyS; TIGR00211 693444000573 DALR anticodon binding domain; Region: DALR_1; pfam05746 693444000574 anticodon binding site; other site 693444000575 tRNA binding surface [nucleotide binding]; other site 693444000576 small toxic polypeptide; Provisional; Region: PRK09759 693444000577 small toxic polypeptide; Provisional; Region: PRK09759 693444000578 small toxic polypeptide; Provisional; Region: PRK09759 693444000579 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 693444000580 DNA-binding site [nucleotide binding]; DNA binding site 693444000581 RNA-binding motif; other site 693444000582 Predicted transcriptional regulator [Transcription]; Region: COG2944 693444000583 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 693444000584 salt bridge; other site 693444000585 non-specific DNA binding site [nucleotide binding]; other site 693444000586 sequence-specific DNA binding site [nucleotide binding]; other site 693444000587 benzoate transport; Region: 2A0115; TIGR00895 693444000588 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693444000589 putative substrate translocation pore; other site 693444000590 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693444000591 Protein of unknown function (DUF3053); Region: DUF3053; pfam11254 693444000592 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 693444000593 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 693444000594 dimerization interface [polypeptide binding]; other site 693444000595 ligand binding site [chemical binding]; other site 693444000596 NADP binding site [chemical binding]; other site 693444000597 catalytic site [active] 693444000598 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693444000599 D-galactonate transporter; Region: 2A0114; TIGR00893 693444000600 putative substrate translocation pore; other site 693444000601 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 693444000602 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 693444000603 substrate binding site [chemical binding]; other site 693444000604 ATP binding site [chemical binding]; other site 693444000605 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 693444000606 Transcriptional regulators [Transcription]; Region: PurR; COG1609 693444000607 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 693444000608 DNA binding site [nucleotide binding] 693444000609 domain linker motif; other site 693444000610 Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283 693444000611 putative dimerization interface [polypeptide binding]; other site 693444000612 putative ligand binding site [chemical binding]; other site 693444000613 putative outer membrane lipoprotein; Provisional; Region: PRK10510 693444000614 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 693444000615 ligand binding site [chemical binding]; other site 693444000616 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 693444000617 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 693444000618 molybdopterin cofactor binding site [chemical binding]; other site 693444000619 substrate binding site [chemical binding]; other site 693444000620 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 693444000621 molybdopterin cofactor binding site; other site 693444000622 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 693444000623 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 693444000624 Coenzyme A binding pocket [chemical binding]; other site 693444000625 3-methyl-adenine DNA glycosylase I; Provisional; Region: PRK10353 693444000626 Autotransporter beta-domain; Region: Autotransporter; cl17461 693444000627 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 693444000628 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693444000629 putative substrate translocation pore; other site 693444000630 phosphoethanolamine transferase; Provisional; Region: PRK11560 693444000631 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 693444000632 Sulfatase; Region: Sulfatase; pfam00884 693444000633 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 693444000634 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 693444000635 peptide binding site [polypeptide binding]; other site 693444000636 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 693444000637 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693444000638 dimer interface [polypeptide binding]; other site 693444000639 conserved gate region; other site 693444000640 putative PBP binding loops; other site 693444000641 ABC-ATPase subunit interface; other site 693444000642 dipeptide transporter; Provisional; Region: PRK10913 693444000643 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 693444000644 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693444000645 dimer interface [polypeptide binding]; other site 693444000646 conserved gate region; other site 693444000647 putative PBP binding loops; other site 693444000648 ABC-ATPase subunit interface; other site 693444000649 dipeptide transporter ATP-binding subunit; Provisional; Region: dppD; PRK11022 693444000650 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 693444000651 Walker A/P-loop; other site 693444000652 ATP binding site [chemical binding]; other site 693444000653 Q-loop/lid; other site 693444000654 ABC transporter signature motif; other site 693444000655 Walker B; other site 693444000656 D-loop; other site 693444000657 H-loop/switch region; other site 693444000658 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 693444000659 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 693444000660 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 693444000661 Walker A/P-loop; other site 693444000662 ATP binding site [chemical binding]; other site 693444000663 Q-loop/lid; other site 693444000664 ABC transporter signature motif; other site 693444000665 Walker B; other site 693444000666 D-loop; other site 693444000667 H-loop/switch region; other site 693444000668 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 693444000669 Protein of unknown function (DUF3260); Region: DUF3260; pfam11658 693444000670 Protein of unknown function (DUF2636); Region: DUF2636; pfam11120 693444000671 cellulose biosynthesis protein BcsE; Provisional; Region: PRK15045 693444000672 Protein of unknown function (DUF2819); Region: DUF2819; pfam10995 693444000673 Protein of unknown function (DUF2629); Region: DUF2629; pfam10945 693444000674 cell division protein; Provisional; Region: PRK10037 693444000675 cellulose synthase catalytic subunit; Provisional; Region: bcsA; PRK11498 693444000676 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 693444000677 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 693444000678 DXD motif; other site 693444000679 PilZ domain; Region: PilZ; pfam07238 693444000680 cellulose synthase regulator protein; Provisional; Region: PRK11114 693444000681 endo-1,4-D-glucanase; Provisional; Region: PRK11097 693444000682 cellulose synthase subunit BcsC; Provisional; Region: PRK11447 693444000683 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 693444000684 TPR motif; other site 693444000685 binding surface 693444000686 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 693444000687 binding surface 693444000688 TPR motif; other site 693444000689 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 693444000690 TPR motif; other site 693444000691 binding surface 693444000692 Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420 693444000693 putative diguanylate cyclase; Provisional; Region: PRK13561 693444000694 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693444000695 metal binding site [ion binding]; metal-binding site 693444000696 active site 693444000697 I-site; other site 693444000698 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 693444000699 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 693444000700 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 693444000701 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 693444000702 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 693444000703 Homeodomain-like domain; Region: HTH_23; cl17451 693444000704 Winged helix-turn helix; Region: HTH_29; pfam13551 693444000705 Homeodomain-like domain; Region: HTH_32; pfam13565 693444000706 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 693444000707 Integrase core domain; Region: rve; pfam00665 693444000708 Integrase core domain; Region: rve_3; pfam13683 693444000709 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 693444000710 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 693444000711 substrate binding site [chemical binding]; other site 693444000712 ATP binding site [chemical binding]; other site 693444000713 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 693444000714 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 693444000715 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 693444000716 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693444000717 metabolite-proton symporter; Region: 2A0106; TIGR00883 693444000718 putative substrate translocation pore; other site 693444000719 inner membrane protein YhjD; Region: TIGR00766 693444000720 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693444000721 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693444000722 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 693444000723 putative effector binding pocket; other site 693444000724 putative dimerization interface [polypeptide binding]; other site 693444000725 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 693444000726 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 693444000727 NAD(P) binding site [chemical binding]; other site 693444000728 active site 693444000729 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 693444000730 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 693444000731 DNA binding residues [nucleotide binding] 693444000732 dimerization interface [polypeptide binding]; other site 693444000733 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 693444000734 catalytic residue [active] 693444000735 trehalase; Provisional; Region: treF; PRK13270 693444000736 Trehalase; Region: Trehalase; pfam01204 693444000737 SdiA-regulated; Region: SdiA-regulated; pfam06977 693444000738 SdiA-regulated; Region: SdiA-regulated; cd09971 693444000739 putative active site [active] 693444000740 glutathione reductase; Validated; Region: PRK06116 693444000741 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 693444000742 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 693444000743 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 693444000744 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 693444000745 Domain of unknown function (DUF1963); Region: DUF1963; cl01600 693444000746 oligopeptidase A; Provisional; Region: PRK10911 693444000747 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 693444000748 active site 693444000749 Zn binding site [ion binding]; other site 693444000750 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693444000751 S-adenosylmethionine binding site [chemical binding]; other site 693444000752 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 693444000753 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 693444000754 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 693444000755 Predicted transcriptional regulator [Transcription]; Region: COG1959 693444000756 Transcriptional regulator; Region: Rrf2; pfam02082 693444000757 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 693444000758 Ligand Binding Site [chemical binding]; other site 693444000759 universal stress protein UspB; Provisional; Region: PRK04960 693444000760 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 693444000761 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 693444000762 Predicted flavoproteins [General function prediction only]; Region: COG2081 693444000763 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 693444000764 FOG: CBS domain [General function prediction only]; Region: COG0517 693444000765 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 693444000766 Divalent cation transporter; Region: MgtE; pfam01769 693444000767 ykoK leader; D782_0235; IMG reference gene:2507514932 693444000768 HlyD family secretion protein; Region: HlyD; pfam00529 693444000769 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 693444000770 HlyD family secretion protein; Region: HlyD_3; pfam13437 693444000771 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 693444000772 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 693444000773 Walker A/P-loop; other site 693444000774 ATP binding site [chemical binding]; other site 693444000775 Q-loop/lid; other site 693444000776 ABC transporter signature motif; other site 693444000777 Walker B; other site 693444000778 D-loop; other site 693444000779 H-loop/switch region; other site 693444000780 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 693444000781 Walker A/P-loop; other site 693444000782 ATP binding site [chemical binding]; other site 693444000783 Q-loop/lid; other site 693444000784 ABC transporter signature motif; other site 693444000785 Walker B; other site 693444000786 D-loop; other site 693444000787 H-loop/switch region; other site 693444000788 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 693444000789 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 693444000790 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 693444000791 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 693444000792 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 693444000793 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693444000794 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693444000795 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 693444000796 dimerization interface [polypeptide binding]; other site 693444000797 Phenolic acid decarboxylase (PAD); Region: PA_decarbox; pfam05870 693444000798 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 693444000799 Domain of unknown function DUF20; Region: UPF0118; pfam01594 693444000800 major facilitator superfamily transporter; Provisional; Region: PRK05122 693444000801 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693444000802 putative substrate translocation pore; other site 693444000803 hypothetical protein; Provisional; Region: PRK11615 693444000804 hypothetical protein; Provisional; Region: PRK11212 693444000805 SirA (also known as UvrY, and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A...; Region: SirA; cd03423 693444000806 CPxP motif; other site 693444000807 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 693444000808 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 693444000809 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 693444000810 DctM-like transporters; Region: DctM; pfam06808 693444000811 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 693444000812 zinc/cadmium/mercury/lead-transporting ATPase; Provisional; Region: zntA; PRK11033 693444000813 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 693444000814 metal-binding site [ion binding] 693444000815 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 693444000816 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 693444000817 Predicted membrane protein [Function unknown]; Region: COG3714 693444000818 Protein of unknown function (DUF2500); Region: DUF2500; pfam10694 693444000819 hypothetical protein; Provisional; Region: PRK10910 693444000820 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 693444000821 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693444000822 S-adenosylmethionine binding site [chemical binding]; other site 693444000823 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 693444000824 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 693444000825 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 693444000826 P loop; other site 693444000827 GTP binding site [chemical binding]; other site 693444000828 cell division protein FtsE; Provisional; Region: PRK10908 693444000829 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693444000830 Walker A/P-loop; other site 693444000831 ATP binding site [chemical binding]; other site 693444000832 Q-loop/lid; other site 693444000833 ABC transporter signature motif; other site 693444000834 Walker B; other site 693444000835 D-loop; other site 693444000836 H-loop/switch region; other site 693444000837 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 693444000838 putative protein insertion permease FtsX; Region: ftsX; TIGR00439 693444000839 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 693444000840 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 693444000841 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 693444000842 DNA binding residues [nucleotide binding] 693444000843 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 693444000844 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 693444000845 dimerization interface [polypeptide binding]; other site 693444000846 ligand binding site [chemical binding]; other site 693444000847 Protein of unknown function (DUF1778); Region: DUF1778; pfam08681 693444000848 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 693444000849 Acetyltransferase (GNAT) domain; Region: DUF3749; pfam12568 693444000850 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 693444000851 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 693444000852 dimerization interface [polypeptide binding]; other site 693444000853 ligand binding site [chemical binding]; other site 693444000854 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 693444000855 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 693444000856 TM-ABC transporter signature motif; other site 693444000857 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 693444000858 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 693444000859 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 693444000860 TM-ABC transporter signature motif; other site 693444000861 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 693444000862 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 693444000863 Walker A/P-loop; other site 693444000864 ATP binding site [chemical binding]; other site 693444000865 Q-loop/lid; other site 693444000866 ABC transporter signature motif; other site 693444000867 Walker B; other site 693444000868 D-loop; other site 693444000869 H-loop/switch region; other site 693444000870 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livF; PRK11614 693444000871 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 693444000872 Walker A/P-loop; other site 693444000873 ATP binding site [chemical binding]; other site 693444000874 Q-loop/lid; other site 693444000875 ABC transporter signature motif; other site 693444000876 Walker B; other site 693444000877 D-loop; other site 693444000878 H-loop/switch region; other site 693444000879 glycerol-3-phosphate transporter periplasmic binding protein; Provisional; Region: PRK10974 693444000880 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 693444000881 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 693444000882 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693444000883 dimer interface [polypeptide binding]; other site 693444000884 conserved gate region; other site 693444000885 putative PBP binding loops; other site 693444000886 ABC-ATPase subunit interface; other site 693444000887 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 693444000888 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693444000889 dimer interface [polypeptide binding]; other site 693444000890 conserved gate region; other site 693444000891 putative PBP binding loops; other site 693444000892 ABC-ATPase subunit interface; other site 693444000893 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 693444000894 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 693444000895 Walker A/P-loop; other site 693444000896 ATP binding site [chemical binding]; other site 693444000897 Q-loop/lid; other site 693444000898 ABC transporter signature motif; other site 693444000899 Walker B; other site 693444000900 D-loop; other site 693444000901 H-loop/switch region; other site 693444000902 TOBE domain; Region: TOBE_2; pfam08402 693444000903 cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454 693444000904 Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562 693444000905 putative active site [active] 693444000906 catalytic site [active] 693444000907 putative metal binding site [ion binding]; other site 693444000908 hypothetical protein; Provisional; Region: PRK10350 693444000909 gamma-glutamyltranspeptidase; Reviewed; Region: ggt; PRK09615 693444000910 gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066 693444000911 putative acetyltransferase YhhY; Provisional; Region: PRK10140 693444000912 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 693444000913 Coenzyme A binding pocket [chemical binding]; other site 693444000914 putative oxidoreductase; Provisional; Region: PRK10206 693444000915 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 693444000916 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 693444000917 Pirin-related protein [General function prediction only]; Region: COG1741 693444000918 Pirin; Region: Pirin; pfam02678 693444000919 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 693444000920 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 693444000921 DNA binding site [nucleotide binding] 693444000922 domain linker motif; other site 693444000923 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 693444000924 putative ligand binding site [chemical binding]; other site 693444000925 putative dimerization interface [polypeptide binding]; other site 693444000926 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 693444000927 ATP-binding site [chemical binding]; other site 693444000928 Gluconate-6-phosphate binding site [chemical binding]; other site 693444000929 Shikimate kinase; Region: SKI; pfam01202 693444000930 low affinity gluconate transporter; Provisional; Region: PRK10472 693444000931 gluconate transporter; Region: gntP; TIGR00791 693444000932 putative antibiotic transporter; Provisional; Region: PRK10739 693444000933 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 693444000934 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 693444000935 glycogen branching enzyme; Provisional; Region: PRK05402 693444000936 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 693444000937 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 693444000938 active site 693444000939 catalytic site [active] 693444000940 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 693444000941 glycogen debranching enzyme; Provisional; Region: PRK03705 693444000942 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 693444000943 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 693444000944 active site 693444000945 catalytic site [active] 693444000946 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 693444000947 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 693444000948 ligand binding site; other site 693444000949 oligomer interface; other site 693444000950 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 693444000951 dimer interface [polypeptide binding]; other site 693444000952 N-terminal domain interface [polypeptide binding]; other site 693444000953 sulfate 1 binding site; other site 693444000954 glycogen synthase; Provisional; Region: glgA; PRK00654 693444000955 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 693444000956 ADP-binding pocket [chemical binding]; other site 693444000957 homodimer interface [polypeptide binding]; other site 693444000958 glycogen phosphorylase; Provisional; Region: PRK14986 693444000959 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 693444000960 homodimer interface [polypeptide binding]; other site 693444000961 active site pocket [active] 693444000962 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 693444000963 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 693444000964 active site residue [active] 693444000965 intramembrane serine protease GlpG; Provisional; Region: PRK10907 693444000966 Protein of unknown function (DUF3582); Region: DUF3582; pfam12122 693444000967 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 693444000968 DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906 693444000969 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 693444000970 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 693444000971 putative symporter YagG; Provisional; Region: PRK09669 693444000972 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693444000973 putative substrate translocation pore; other site 693444000974 transcriptional regulator MalT; Provisional; Region: PRK04841 693444000975 AAA ATPase domain; Region: AAA_16; pfam13191 693444000976 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 693444000977 DNA binding residues [nucleotide binding] 693444000978 dimerization interface [polypeptide binding]; other site 693444000979 maltodextrin phosphorylase; Provisional; Region: PRK14985 693444000980 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 693444000981 homodimer interface [polypeptide binding]; other site 693444000982 active site pocket [active] 693444000983 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 693444000984 4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711 693444000985 high-affinity gluconate transporter; Provisional; Region: PRK14984 693444000986 gluconate transporter; Region: gntP; TIGR00791 693444000987 Fe/S biogenesis protein NfuA; Provisional; Region: PRK11190 693444000988 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 693444000989 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 693444000990 DNA utilization protein GntX; Provisional; Region: PRK11595 693444000991 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 693444000992 active site 693444000993 carboxylesterase BioH; Provisional; Region: PRK10349 693444000994 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 693444000995 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 693444000996 ferrous iron transport protein FeoC; Provisional; Region: PRK15431 693444000997 ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554 693444000998 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 693444000999 G1 box; other site 693444001000 GTP/Mg2+ binding site [chemical binding]; other site 693444001001 Switch I region; other site 693444001002 G2 box; other site 693444001003 G3 box; other site 693444001004 Switch II region; other site 693444001005 G4 box; other site 693444001006 G5 box; other site 693444001007 Nucleoside recognition; Region: Gate; pfam07670 693444001008 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 693444001009 Nucleoside recognition; Region: Gate; pfam07670 693444001010 ferrous iron transport protein A; Reviewed; Region: feoA; PRK09555 693444001011 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 693444001012 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 693444001013 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 693444001014 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 693444001015 RNA binding site [nucleotide binding]; other site 693444001016 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 693444001017 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 693444001018 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 693444001019 osmolarity response regulator; Provisional; Region: ompR; PRK09468 693444001020 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693444001021 active site 693444001022 phosphorylation site [posttranslational modification] 693444001023 intermolecular recognition site; other site 693444001024 dimerization interface [polypeptide binding]; other site 693444001025 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 693444001026 DNA binding site [nucleotide binding] 693444001027 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 693444001028 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 693444001029 dimerization interface [polypeptide binding]; other site 693444001030 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 693444001031 dimer interface [polypeptide binding]; other site 693444001032 phosphorylation site [posttranslational modification] 693444001033 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693444001034 ATP binding site [chemical binding]; other site 693444001035 Mg2+ binding site [ion binding]; other site 693444001036 G-X-G motif; other site 693444001037 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 693444001038 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 693444001039 active site 693444001040 substrate-binding site [chemical binding]; other site 693444001041 metal-binding site [ion binding] 693444001042 ATP binding site [chemical binding]; other site 693444001043 Domain of unknown function (DUF4153); Region: DUF4153; pfam13687 693444001044 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 693444001045 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 693444001046 dimerization interface [polypeptide binding]; other site 693444001047 domain crossover interface; other site 693444001048 redox-dependent activation switch; other site 693444001049 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 693444001050 RNA binding surface [nucleotide binding]; other site 693444001051 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 693444001052 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 693444001053 motif II; other site 693444001054 Intracellular growth attenuator protein IgaA; Region: IgaA; pfam07095 693444001055 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 693444001056 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 693444001057 ADP-ribose binding site [chemical binding]; other site 693444001058 dimer interface [polypeptide binding]; other site 693444001059 active site 693444001060 nudix motif; other site 693444001061 metal binding site [ion binding]; metal-binding site 693444001062 penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636 693444001063 Transglycosylase; Region: Transgly; pfam00912 693444001064 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 693444001065 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 693444001066 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 693444001067 Protein of unknown function (DUF2531); Region: DUF2531; pfam10748 693444001068 outer membrane porin HofQ; Provisional; Region: hofQ; PRK10560 693444001069 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 693444001070 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 693444001071 shikimate kinase; Reviewed; Region: aroK; PRK00131 693444001072 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 693444001073 ADP binding site [chemical binding]; other site 693444001074 magnesium binding site [ion binding]; other site 693444001075 putative shikimate binding site; other site 693444001076 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 693444001077 active site 693444001078 dimer interface [polypeptide binding]; other site 693444001079 metal binding site [ion binding]; metal-binding site 693444001080 cell division protein DamX; Validated; Region: PRK10905 693444001081 cell division protein DamX; Validated; Region: PRK10905 693444001082 DNA adenine methylase; Provisional; Region: PRK10904 693444001083 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 693444001084 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 693444001085 substrate binding site [chemical binding]; other site 693444001086 hexamer interface [polypeptide binding]; other site 693444001087 metal binding site [ion binding]; metal-binding site 693444001088 phosphoglycolate phosphatase; Provisional; Region: PRK13222 693444001089 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 693444001090 motif I; other site 693444001091 active site 693444001092 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 693444001093 motif II; other site 693444001094 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 693444001095 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 693444001096 active site 693444001097 HIGH motif; other site 693444001098 dimer interface [polypeptide binding]; other site 693444001099 KMSKS motif; other site 693444001100 Protein of unknown function (DUF4223); Region: DUF4223; pfam13978 693444001101 siroheme synthase; Provisional; Region: cysG; PRK10637 693444001102 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 693444001103 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 693444001104 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 693444001105 active site 693444001106 SAM binding site [chemical binding]; other site 693444001107 homodimer interface [polypeptide binding]; other site 693444001108 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 693444001109 nitrite reductase subunit NirD; Provisional; Region: PRK14989 693444001110 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 693444001111 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 693444001112 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 693444001113 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 693444001114 cytosine deaminase; Provisional; Region: PRK09230 693444001115 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 693444001116 active site 693444001117 putative transporter; Provisional; Region: PRK03699 693444001118 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693444001119 putative substrate translocation pore; other site 693444001120 peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903 693444001121 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 693444001122 substrate binding site [chemical binding]; other site 693444001123 hypothetical protein; Provisional; Region: PRK10204 693444001124 cell filamentation protein Fic; Provisional; Region: PRK10347 693444001125 Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184 693444001126 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 693444001127 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 693444001128 glutamine binding [chemical binding]; other site 693444001129 catalytic triad [active] 693444001130 bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093 693444001131 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 693444001132 inhibitor-cofactor binding pocket; inhibition site 693444001133 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693444001134 catalytic residue [active] 693444001135 integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667 693444001136 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 693444001137 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 693444001138 DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753 693444001139 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 693444001140 ligand binding site [chemical binding]; other site 693444001141 flexible hinge region; other site 693444001142 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 693444001143 putative switch regulator; other site 693444001144 non-specific DNA interactions [nucleotide binding]; other site 693444001145 DNA binding site [nucleotide binding] 693444001146 sequence specific DNA binding site [nucleotide binding]; other site 693444001147 putative cAMP binding site [chemical binding]; other site 693444001148 hypothetical protein; Provisional; Region: PRK10738 693444001149 phosphoribulokinase; Provisional; Region: PRK15453 693444001150 active site 693444001151 hypothetical protein; Provisional; Region: PRK04966 693444001152 putative hydrolase; Provisional; Region: PRK10985 693444001153 malonate decarboxylase, alpha subunit; Region: mdcA; TIGR01110 693444001154 Coenzyme A transferase; Region: CoA_trans; cl17247 693444001155 triphosphoribosyl-dephospho-CoA synthase; Validated; Region: PRK01237 693444001156 Malonate decarboxylase delta subunit (MdcD); Region: ACP; cl06082 693444001157 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189 693444001158 Malonate decarboxylase gamma subunit (MdcE); Region: MdcE; pfam06833 693444001159 he Auxin Efflux Carrier (AEC) Family; Region: 2a69; TIGR00946 693444001160 phosphoribosyl-dephospho-CoA transferase; Provisional; Region: PRK01293 693444001161 Phosphoribosyl-dephospho-CoA transferase MdcG; Region: MdcG; pfam10620 693444001162 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 693444001163 malonate decarboxylase, epsilon subunit; Region: malonate_mdcH; TIGR03131 693444001164 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693444001165 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693444001166 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 693444001167 dimerization interface [polypeptide binding]; other site 693444001168 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 693444001169 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693444001170 Walker A/P-loop; other site 693444001171 ATP binding site [chemical binding]; other site 693444001172 Q-loop/lid; other site 693444001173 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 693444001174 ABC transporter; Region: ABC_tran_2; pfam12848 693444001175 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 693444001176 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 693444001177 glutathione-regulated potassium-efflux system ancillary protein KefG; Provisional; Region: PRK04930 693444001178 glutathione-regulated potassium-efflux system protein KefB; Provisional; Region: PRK03659 693444001179 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 693444001180 TrkA-N domain; Region: TrkA_N; pfam02254 693444001181 Predicted nucleic-acid-binding protein containing a Zn-ribbon domain [General function prediction only]; Region: COG3529 693444001182 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 693444001183 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 693444001184 phi X174 lysis protein; Provisional; Region: PRK02793 693444001185 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK10902 693444001186 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 693444001187 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 693444001188 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 693444001189 YheO-like PAS domain; Region: PAS_6; pfam08348 693444001190 HTH domain; Region: HTH_22; pfam13309 693444001191 sulfur transfer complex subunit TusD; Validated; Region: PRK00207 693444001192 sulfur relay protein TusC; Validated; Region: PRK00211 693444001193 sulfur transfer complex subunit TusB; Provisional; Region: PRK13510 693444001194 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 693444001195 S17 interaction site [polypeptide binding]; other site 693444001196 S8 interaction site; other site 693444001197 16S rRNA interaction site [nucleotide binding]; other site 693444001198 streptomycin interaction site [chemical binding]; other site 693444001199 23S rRNA interaction site [nucleotide binding]; other site 693444001200 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 693444001201 30S ribosomal protein S7; Validated; Region: PRK05302 693444001202 elongation factor G; Reviewed; Region: PRK00007 693444001203 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 693444001204 G1 box; other site 693444001205 putative GEF interaction site [polypeptide binding]; other site 693444001206 GTP/Mg2+ binding site [chemical binding]; other site 693444001207 Switch I region; other site 693444001208 G2 box; other site 693444001209 G3 box; other site 693444001210 Switch II region; other site 693444001211 G4 box; other site 693444001212 G5 box; other site 693444001213 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 693444001214 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 693444001215 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 693444001216 elongation factor Tu; Reviewed; Region: PRK00049 693444001217 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 693444001218 G1 box; other site 693444001219 GEF interaction site [polypeptide binding]; other site 693444001220 GTP/Mg2+ binding site [chemical binding]; other site 693444001221 Switch I region; other site 693444001222 G2 box; other site 693444001223 G3 box; other site 693444001224 Switch II region; other site 693444001225 G4 box; other site 693444001226 G5 box; other site 693444001227 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 693444001228 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 693444001229 Antibiotic Binding Site [chemical binding]; other site 693444001230 bacterioferritin-associated ferredoxin; Provisional; Region: PRK10509 693444001231 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 693444001232 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 693444001233 heme binding site [chemical binding]; other site 693444001234 ferroxidase pore; other site 693444001235 ferroxidase diiron center [ion binding]; other site 693444001236 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 693444001237 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 693444001238 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 693444001239 50S ribosomal protein L3, bacterial; Region: L3_bact; TIGR03625 693444001240 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 693444001241 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 693444001242 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 693444001243 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 693444001244 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 693444001245 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 693444001246 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 693444001247 protein-rRNA interface [nucleotide binding]; other site 693444001248 putative translocon binding site; other site 693444001249 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 693444001250 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 693444001251 G-X-X-G motif; other site 693444001252 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 693444001253 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 693444001254 23S rRNA interface [nucleotide binding]; other site 693444001255 5S rRNA interface [nucleotide binding]; other site 693444001256 putative antibiotic binding site [chemical binding]; other site 693444001257 L25 interface [polypeptide binding]; other site 693444001258 L27 interface [polypeptide binding]; other site 693444001259 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 693444001260 23S rRNA interface [nucleotide binding]; other site 693444001261 putative translocon interaction site; other site 693444001262 signal recognition particle (SRP54) interaction site; other site 693444001263 L23 interface [polypeptide binding]; other site 693444001264 trigger factor interaction site; other site 693444001265 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 693444001266 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 693444001267 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 693444001268 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 693444001269 RNA binding site [nucleotide binding]; other site 693444001270 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 693444001271 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 693444001272 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 693444001273 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 693444001274 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 693444001275 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 693444001276 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 693444001277 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 693444001278 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 693444001279 23S rRNA interface [nucleotide binding]; other site 693444001280 5S rRNA interface [nucleotide binding]; other site 693444001281 L27 interface [polypeptide binding]; other site 693444001282 L5 interface [polypeptide binding]; other site 693444001283 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 693444001284 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 693444001285 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 693444001286 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 693444001287 23S rRNA binding site [nucleotide binding]; other site 693444001288 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 693444001289 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 693444001290 SecY translocase; Region: SecY; pfam00344 693444001291 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 693444001292 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 693444001293 30S ribosomal protein S13; Region: bact_S13; TIGR03631 693444001294 30S ribosomal protein S11; Validated; Region: PRK05309 693444001295 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 693444001296 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 693444001297 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 693444001298 RNA binding surface [nucleotide binding]; other site 693444001299 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 693444001300 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 693444001301 alphaNTD homodimer interface [polypeptide binding]; other site 693444001302 alphaNTD - beta interaction site [polypeptide binding]; other site 693444001303 alphaNTD - beta' interaction site [polypeptide binding]; other site 693444001304 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 693444001305 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 693444001306 hypothetical protein; Provisional; Region: PRK10203 693444001307 zinc-responsive transcriptional regulator; Provisional; Region: zntR; PRK09514 693444001308 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 693444001309 DNA binding residues [nucleotide binding] 693444001310 dimer interface [polypeptide binding]; other site 693444001311 metal binding site [ion binding]; metal-binding site 693444001312 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3036 693444001313 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 693444001314 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 693444001315 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 693444001316 TrkA-N domain; Region: TrkA_N; pfam02254 693444001317 TrkA-C domain; Region: TrkA_C; pfam02080 693444001318 TrkA-N domain; Region: TrkA_N; pfam02254 693444001319 TrkA-C domain; Region: TrkA_C; pfam02080 693444001320 16S rRNA methyltransferase B; Provisional; Region: PRK10901 693444001321 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 693444001322 putative RNA binding site [nucleotide binding]; other site 693444001323 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693444001324 S-adenosylmethionine binding site [chemical binding]; other site 693444001325 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 693444001326 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 693444001327 putative active site [active] 693444001328 substrate binding site [chemical binding]; other site 693444001329 putative cosubstrate binding site; other site 693444001330 catalytic site [active] 693444001331 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 693444001332 substrate binding site [chemical binding]; other site 693444001333 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 693444001334 active site 693444001335 catalytic residues [active] 693444001336 metal binding site [ion binding]; metal-binding site 693444001337 hypothetical protein; Provisional; Region: PRK10736 693444001338 DNA protecting protein DprA; Region: dprA; TIGR00732 693444001339 hypothetical protein; Validated; Region: PRK03430 693444001340 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 693444001341 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 693444001342 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 693444001343 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 693444001344 tRNA(ANN) t(6)A37 threonylcarbamoyladenosine modification protein; Provisional; Region: PRK10634 693444001345 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 693444001346 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 693444001347 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 693444001348 shikimate binding site; other site 693444001349 NAD(P) binding site [chemical binding]; other site 693444001350 Protein of unknown function (DUF1488); Region: DUF1488; pfam07369 693444001351 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 693444001352 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 693444001353 trimer interface [polypeptide binding]; other site 693444001354 putative metal binding site [ion binding]; other site 693444001355 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 693444001356 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 693444001357 Walker A/P-loop; other site 693444001358 ATP binding site [chemical binding]; other site 693444001359 Q-loop/lid; other site 693444001360 ABC transporter signature motif; other site 693444001361 Walker B; other site 693444001362 D-loop; other site 693444001363 H-loop/switch region; other site 693444001364 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693444001365 dimer interface [polypeptide binding]; other site 693444001366 conserved gate region; other site 693444001367 putative PBP binding loops; other site 693444001368 ABC-ATPase subunit interface; other site 693444001369 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597 693444001370 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693444001371 conserved gate region; other site 693444001372 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693444001373 dimer interface [polypeptide binding]; other site 693444001374 ABC-ATPase subunit interface; other site 693444001375 putative PBP binding loops; other site 693444001376 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 693444001377 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 693444001378 substrate binding pocket [chemical binding]; other site 693444001379 membrane-bound complex binding site; other site 693444001380 hinge residues; other site 693444001381 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 693444001382 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 693444001383 Protein export membrane protein; Region: SecD_SecF; cl14618 693444001384 Protein export membrane protein; Region: SecD_SecF; cl14618 693444001385 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 693444001386 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 693444001387 HlyD family secretion protein; Region: HlyD_3; pfam13437 693444001388 DNA-binding transcriptional regulator EnvR; Provisional; Region: PRK09975 693444001389 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 693444001390 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 693444001391 Protein of unknown function (DUF2556); Region: DUF2556; pfam10831 693444001392 Factor for inversion stimulation Fis, transcriptional activator [Transcription / DNA replication, recombination, and repair]; Region: Fis; COG2901 693444001393 global DNA-binding transcriptional dual regulator Fis; Provisional; Region: fis; PRK00430 693444001394 tRNA-dihydrouridine synthase B; Provisional; Region: PRK10415 693444001395 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 693444001396 FMN binding site [chemical binding]; other site 693444001397 active site 693444001398 catalytic residues [active] 693444001399 substrate binding site [chemical binding]; other site 693444001400 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 693444001401 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 693444001402 Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; Region: SLC5sbd_PanF; cd10327 693444001403 Na binding site [ion binding]; other site 693444001404 hypothetical protein; Provisional; Region: PRK10633 693444001405 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 693444001406 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 693444001407 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 693444001408 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 693444001409 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 693444001410 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 693444001411 carboxyltransferase (CT) interaction site; other site 693444001412 biotinylation site [posttranslational modification]; other site 693444001413 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 693444001414 Dehydroquinase class II; Region: DHquinase_II; pfam01220 693444001415 active site 693444001416 trimer interface [polypeptide binding]; other site 693444001417 dimer interface [polypeptide binding]; other site 693444001418 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 693444001419 TMAO/DMSO reductase; Reviewed; Region: PRK05363 693444001420 YedY_like molybdopterin cofactor (Moco) binding domain, a subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. Escherichia coli YedY has been propsed to form a heterodimer, consisting of a soluble catalytic subunit termed YedY; Region: YedY_like_Moco; cd02107 693444001421 Moco binding site; other site 693444001422 metal coordination site [ion binding]; other site 693444001423 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 693444001424 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 693444001425 NADP binding site [chemical binding]; other site 693444001426 dimer interface [polypeptide binding]; other site 693444001427 regulatory protein CsrD; Provisional; Region: PRK11059 693444001428 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693444001429 metal binding site [ion binding]; metal-binding site 693444001430 active site 693444001431 I-site; other site 693444001432 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 693444001433 rod shape-determining protein MreB; Provisional; Region: PRK13927 693444001434 MreB and similar proteins; Region: MreB_like; cd10225 693444001435 nucleotide binding site [chemical binding]; other site 693444001436 Mg binding site [ion binding]; other site 693444001437 putative protofilament interaction site [polypeptide binding]; other site 693444001438 RodZ interaction site [polypeptide binding]; other site 693444001439 rod shape-determining protein MreC; Region: mreC; TIGR00219 693444001440 rod shape-determining protein MreC; Region: MreC; pfam04085 693444001441 rod shape-determining protein MreD; Provisional; Region: PRK11060 693444001442 Maf-like protein; Region: Maf; pfam02545 693444001443 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 693444001444 active site 693444001445 dimer interface [polypeptide binding]; other site 693444001446 ribonuclease G; Provisional; Region: PRK11712 693444001447 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 693444001448 homodimer interface [polypeptide binding]; other site 693444001449 oligonucleotide binding site [chemical binding]; other site 693444001450 hypothetical protein; Provisional; Region: PRK10899 693444001451 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 693444001452 protease TldD; Provisional; Region: tldD; PRK10735 693444001453 transcriptional regulator; Provisional; Region: PRK10632 693444001454 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693444001455 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 693444001456 putative effector binding pocket; other site 693444001457 dimerization interface [polypeptide binding]; other site 693444001458 efflux system membrane protein; Provisional; Region: PRK11594 693444001459 p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559 693444001460 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 693444001461 HlyD family secretion protein; Region: HlyD_3; pfam13437 693444001462 p-hydroxybenzoic acid efflux subunit AaeB; Provisional; Region: PRK10631 693444001463 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 693444001464 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it thus inhibiting its potentially lethal RNase activity inside the cell; Region: Barstar; cd05142 693444001465 RNAase interaction site [polypeptide binding]; other site 693444001466 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 693444001467 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 693444001468 arginine repressor; Provisional; Region: PRK05066 693444001469 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 693444001470 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 693444001471 malate dehydrogenase; Provisional; Region: PRK05086 693444001472 Glyoxysomal and mitochondrial malate dehydrogenases; Region: MDH_glyoxysomal_mitochondrial; cd01337 693444001473 NAD binding site [chemical binding]; other site 693444001474 dimerization interface [polypeptide binding]; other site 693444001475 Substrate binding site [chemical binding]; other site 693444001476 Autotransporter beta-domain; Region: Autotransporter; pfam03797 693444001477 serine endoprotease; Provisional; Region: PRK10898 693444001478 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 693444001479 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 693444001480 serine endoprotease; Provisional; Region: PRK10139 693444001481 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 693444001482 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 693444001483 protein binding site [polypeptide binding]; other site 693444001484 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 693444001485 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3105 693444001486 hypothetical protein; Provisional; Region: PRK11677 693444001487 Predicted ATPase [General function prediction only]; Region: COG1485 693444001488 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 693444001489 23S rRNA interface [nucleotide binding]; other site 693444001490 L3 interface [polypeptide binding]; other site 693444001491 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 693444001492 stringent starvation protein A; Provisional; Region: sspA; PRK09481 693444001493 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 693444001494 C-terminal domain interface [polypeptide binding]; other site 693444001495 putative GSH binding site (G-site) [chemical binding]; other site 693444001496 dimer interface [polypeptide binding]; other site 693444001497 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 693444001498 dimer interface [polypeptide binding]; other site 693444001499 N-terminal domain interface [polypeptide binding]; other site 693444001500 ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798 693444001501 transcriptional regulator NanR; Provisional; Region: PRK03837 693444001502 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 693444001503 DNA-binding site [nucleotide binding]; DNA binding site 693444001504 FCD domain; Region: FCD; pfam07729 693444001505 N-acetylneuraminate lyase; Provisional; Region: PRK04147 693444001506 N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL); Region: NAL; cd00954 693444001507 inhibitor site; inhibition site 693444001508 active site 693444001509 dimer interface [polypeptide binding]; other site 693444001510 catalytic residue [active] 693444001511 putative sialic acid transporter; Provisional; Region: PRK03893 693444001512 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693444001513 putative substrate translocation pore; other site 693444001514 Putative N-acetylmannosamine-6-phosphate epimerase [Carbohydrate transport and metabolism]; Region: NanE; COG3010 693444001515 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 693444001516 putative active site cavity [active] 693444001517 N-acetylmannosamine kinase; Provisional; Region: PRK05082 693444001518 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 693444001519 nucleotide binding site [chemical binding]; other site 693444001520 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 693444001521 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 693444001522 glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318 693444001523 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 693444001524 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 693444001525 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 693444001526 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 693444001527 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 693444001528 active site 693444001529 dimer interface [polypeptide binding]; other site 693444001530 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 693444001531 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 693444001532 active site 693444001533 FMN binding site [chemical binding]; other site 693444001534 substrate binding site [chemical binding]; other site 693444001535 3Fe-4S cluster binding site [ion binding]; other site 693444001536 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 693444001537 domain interface; other site 693444001538 radical SAM protein, TIGR01212 family; Region: TIGR01212 693444001539 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 693444001540 FeS/SAM binding site; other site 693444001541 aerobic respiration control sensor protein ArcB; Provisional; Region: PRK11091 693444001542 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 693444001543 putative active site [active] 693444001544 heme pocket [chemical binding]; other site 693444001545 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 693444001546 dimer interface [polypeptide binding]; other site 693444001547 phosphorylation site [posttranslational modification] 693444001548 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693444001549 ATP binding site [chemical binding]; other site 693444001550 Mg2+ binding site [ion binding]; other site 693444001551 G-X-G motif; other site 693444001552 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693444001553 active site 693444001554 phosphorylation site [posttranslational modification] 693444001555 intermolecular recognition site; other site 693444001556 dimerization interface [polypeptide binding]; other site 693444001557 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 693444001558 putative binding surface; other site 693444001559 active site 693444001560 isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780 693444001561 Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133 693444001562 conserved cys residue [active] 693444001563 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 693444001564 Transglycosylase; Region: Transgly; cl17702 693444001565 hypothetical protein; Provisional; Region: PRK10345 693444001566 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 693444001567 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 693444001568 dimerization domain swap beta strand [polypeptide binding]; other site 693444001569 regulatory protein interface [polypeptide binding]; other site 693444001570 active site 693444001571 regulatory phosphorylation site [posttranslational modification]; other site 693444001572 P-loop ATPase protein family; Region: ATP_bind_2; pfam03668 693444001573 AAA domain; Region: AAA_18; pfam13238 693444001574 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 693444001575 active site 693444001576 phosphorylation site [posttranslational modification] 693444001577 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 693444001578 30S subunit binding site; other site 693444001579 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 693444001580 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 693444001581 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 693444001582 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 693444001583 lipopolysaccharide ABC transporter ATP-binding protein; Provisional; Region: PRK10895 693444001584 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 693444001585 Walker A/P-loop; other site 693444001586 ATP binding site [chemical binding]; other site 693444001587 Q-loop/lid; other site 693444001588 ABC transporter signature motif; other site 693444001589 Walker B; other site 693444001590 D-loop; other site 693444001591 H-loop/switch region; other site 693444001592 lipopolysaccharide transport periplasmic protein LptA; Provisional; Region: PRK10894 693444001593 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 693444001594 lipopolysaccharide exporter periplasmic protein; Provisional; Region: PRK10893 693444001595 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 693444001596 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase; Provisional; Region: PRK09484 693444001597 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 693444001598 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 693444001599 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 693444001600 putative active site [active] 693444001601 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 693444001602 putative calcium/sodium:proton antiporter; Provisional; Region: PRK10734 693444001603 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 693444001604 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 693444001605 putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831 693444001606 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 693444001607 Walker A/P-loop; other site 693444001608 ATP binding site [chemical binding]; other site 693444001609 Q-loop/lid; other site 693444001610 ABC transporter signature motif; other site 693444001611 Walker B; other site 693444001612 D-loop; other site 693444001613 H-loop/switch region; other site 693444001614 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 693444001615 conserved hypothetical integral membrane protein; Region: TIGR00056 693444001616 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 693444001617 mce related protein; Region: MCE; pfam02470 693444001618 ABC transporter periplasmic binding protein MlaC; Provisional; Region: PRK15117 693444001619 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 693444001620 anti sigma factor interaction site; other site 693444001621 regulatory phosphorylation site [posttranslational modification]; other site 693444001622 Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007 693444001623 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 693444001624 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 693444001625 hinge; other site 693444001626 active site 693444001627 Winged helix-turn-helix DNA-binding; Region: HTH_35; cl17423 693444001628 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 693444001629 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 693444001630 substrate binding pocket [chemical binding]; other site 693444001631 chain length determination region; other site 693444001632 substrate-Mg2+ binding site; other site 693444001633 catalytic residues [active] 693444001634 aspartate-rich region 1; other site 693444001635 active site lid residues [active] 693444001636 aspartate-rich region 2; other site 693444001637 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 693444001638 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 693444001639 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 693444001640 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 693444001641 EamA-like transporter family; Region: EamA; pfam00892 693444001642 EamA-like transporter family; Region: EamA; pfam00892 693444001643 GTPase CgtA; Reviewed; Region: obgE; PRK12298 693444001644 GTP1/OBG; Region: GTP1_OBG; pfam01018 693444001645 Obg GTPase; Region: Obg; cd01898 693444001646 G1 box; other site 693444001647 GTP/Mg2+ binding site [chemical binding]; other site 693444001648 Switch I region; other site 693444001649 G2 box; other site 693444001650 G3 box; other site 693444001651 Switch II region; other site 693444001652 G4 box; other site 693444001653 G5 box; other site 693444001654 Sulfatase; Region: Sulfatase; cl17466 693444001655 D-alanyl-D-alanine carboxypeptidase/endopeptidase; Provisional; Region: PRK11113 693444001656 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 693444001657 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 693444001658 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 693444001659 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 693444001660 RNA-binding protein YhbY; Provisional; Region: PRK10343 693444001661 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 693444001662 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693444001663 S-adenosylmethionine binding site [chemical binding]; other site 693444001664 ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733 693444001665 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693444001666 Walker A motif; other site 693444001667 ATP binding site [chemical binding]; other site 693444001668 Walker B motif; other site 693444001669 arginine finger; other site 693444001670 Peptidase family M41; Region: Peptidase_M41; pfam01434 693444001671 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 693444001672 dihydropteroate synthase; Region: DHPS; TIGR01496 693444001673 substrate binding pocket [chemical binding]; other site 693444001674 dimer interface [polypeptide binding]; other site 693444001675 inhibitor binding site; inhibition site 693444001676 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 693444001677 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 693444001678 active site 693444001679 substrate binding site [chemical binding]; other site 693444001680 metal binding site [ion binding]; metal-binding site 693444001681 Toxin-coregulated pilus subunit TcpA; Region: TcpA; pfam05946 693444001682 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 693444001683 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 693444001684 Toxin co-regulated pilus biosynthesis protein Q; Region: TcpQ; pfam10671 693444001685 type IVB pilus formation outer membrane protein, R64 PilN family; Region: pilus_B_mal_scr; TIGR02520 693444001686 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 693444001687 Type II/IV secretion system protein; Region: T2SE; pfam00437 693444001688 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 693444001689 Walker A motif; other site 693444001690 ATP binding site [chemical binding]; other site 693444001691 Walker B motif; other site 693444001692 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 693444001693 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 693444001694 portal vertex protein; Provisional; Region: 20; PHA02531 693444001695 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 693444001696 Peptidase family M23; Region: Peptidase_M23; pfam01551 693444001697 Preprotein translocase SecG subunit; Region: SecG; pfam03840 693444001698 Predicted transcriptional regulator [Transcription]; Region: COG3905 693444001699 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 693444001700 argininosuccinate synthase; Validated; Region: PRK05370 693444001701 argininosuccinate synthase; Provisional; Region: PRK13820 693444001702 ribosome maturation protein RimP; Reviewed; Region: PRK00092 693444001703 Sm and related proteins; Region: Sm_like; cl00259 693444001704 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 693444001705 putative oligomer interface [polypeptide binding]; other site 693444001706 putative RNA binding site [nucleotide binding]; other site 693444001707 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 693444001708 NusA N-terminal domain; Region: NusA_N; pfam08529 693444001709 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 693444001710 RNA binding site [nucleotide binding]; other site 693444001711 homodimer interface [polypeptide binding]; other site 693444001712 NusA-like KH domain; Region: KH_5; pfam13184 693444001713 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 693444001714 G-X-X-G motif; other site 693444001715 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 693444001716 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 693444001717 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 693444001718 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 693444001719 translation initiation factor IF-2; Region: IF-2; TIGR00487 693444001720 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 693444001721 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 693444001722 G1 box; other site 693444001723 putative GEF interaction site [polypeptide binding]; other site 693444001724 GTP/Mg2+ binding site [chemical binding]; other site 693444001725 Switch I region; other site 693444001726 G2 box; other site 693444001727 G3 box; other site 693444001728 Switch II region; other site 693444001729 G4 box; other site 693444001730 G5 box; other site 693444001731 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 693444001732 Translation-initiation factor 2; Region: IF-2; pfam11987 693444001733 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 693444001734 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 693444001735 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 693444001736 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 693444001737 RNA binding site [nucleotide binding]; other site 693444001738 active site 693444001739 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 693444001740 Ribosomal S15 leader; D782_0543; IMG reference gene:2507515240 693444001741 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 693444001742 16S/18S rRNA binding site [nucleotide binding]; other site 693444001743 S13e-L30e interaction site [polypeptide binding]; other site 693444001744 25S rRNA binding site [nucleotide binding]; other site 693444001745 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 693444001746 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 693444001747 RNase E interface [polypeptide binding]; other site 693444001748 trimer interface [polypeptide binding]; other site 693444001749 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 693444001750 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 693444001751 RNase E interface [polypeptide binding]; other site 693444001752 trimer interface [polypeptide binding]; other site 693444001753 active site 693444001754 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 693444001755 putative nucleic acid binding region [nucleotide binding]; other site 693444001756 G-X-X-G motif; other site 693444001757 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 693444001758 RNA binding site [nucleotide binding]; other site 693444001759 domain interface; other site 693444001760 lipoprotein NlpI; Provisional; Region: PRK11189 693444001761 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 693444001762 binding surface 693444001763 TPR motif; other site 693444001764 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 693444001765 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 693444001766 ATP binding site [chemical binding]; other site 693444001767 Mg++ binding site [ion binding]; other site 693444001768 motif III; other site 693444001769 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 693444001770 nucleotide binding region [chemical binding]; other site 693444001771 ATP-binding site [chemical binding]; other site 693444001772 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 693444001773 putative RNA binding site [nucleotide binding]; other site 693444001774 tryptophan permease; Provisional; Region: PRK10483 693444001775 aromatic amino acid transport protein; Region: araaP; TIGR00837 693444001776 hypothetical protein; Provisional; Region: PRK10508 693444001777 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 693444001778 putative protease; Provisional; Region: PRK15447 693444001779 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 693444001780 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 693444001781 Peptidase family U32; Region: Peptidase_U32; pfam01136 693444001782 Putative lipid carrier protein [Lipid metabolism]; Region: COG3154 693444001783 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 693444001784 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 693444001785 Coenzyme A binding pocket [chemical binding]; other site 693444001786 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 693444001787 GIY-YIG motif/motif A; other site 693444001788 putative active site [active] 693444001789 putative metal binding site [ion binding]; other site 693444001790 hypothetical protein; Provisional; Region: PRK03467 693444001791 intracellular protease, PfpI family; Region: PfpI; TIGR01382 693444001792 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 693444001793 proposed catalytic triad [active] 693444001794 conserved cys residue [active] 693444001795 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 693444001796 NADH(P)-binding; Region: NAD_binding_10; pfam13460 693444001797 NAD binding site [chemical binding]; other site 693444001798 active site 693444001799 outer membrane lipoprotein; Provisional; Region: PRK11023 693444001800 BON domain; Region: BON; pfam04972 693444001801 BON domain; Region: BON; pfam04972 693444001802 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 693444001803 dimer interface [polypeptide binding]; other site 693444001804 active site 693444001805 TIGR00252 family protein; Region: TIGR00252 693444001806 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 693444001807 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 693444001808 putative ligand binding site [chemical binding]; other site 693444001809 SAM-dependent 16S ribosomal RNA C1402 ribose 2'-O-methyltransferase; Provisional; Region: PRK14994 693444001810 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 693444001811 putative SAM binding site [chemical binding]; other site 693444001812 putative homodimer interface [polypeptide binding]; other site 693444001813 Fimbrial protein; Region: Fimbrial; cl01416 693444001814 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 693444001815 PapC N-terminal domain; Region: PapC_N; pfam13954 693444001816 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 693444001817 PapC C-terminal domain; Region: PapC_C; pfam13953 693444001818 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 693444001819 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 693444001820 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 693444001821 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 693444001822 galactarate dehydratase; Region: galactar-dH20; TIGR03248 693444001823 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 693444001824 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 693444001825 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693444001826 D-galactonate transporter; Region: 2A0114; TIGR00893 693444001827 putative substrate translocation pore; other site 693444001828 alpha-dehydro-beta-deoxy-D-glucarate aldolase; Provisional; Region: PRK10558 693444001829 tartronate semialdehyde reductase; Provisional; Region: garR; PRK11559 693444001830 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 693444001831 glycerate kinase I; Provisional; Region: PRK10342 693444001832 DNA-binding transcriptional activator TdcA; Provisional; Region: PRK10341 693444001833 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693444001834 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 693444001835 dimerization interface [polypeptide binding]; other site 693444001836 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 693444001837 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 693444001838 tetramer interface [polypeptide binding]; other site 693444001839 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693444001840 catalytic residue [active] 693444001841 threonine/serine transporter TdcC; Provisional; Region: PRK13629 693444001842 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 693444001843 propionate/acetate kinase; Provisional; Region: PRK12379 693444001844 Acetate kinase [Energy production and conversion]; Region: ackA; COG0282 693444001845 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 693444001846 Pyruvate formate lyase 1; Region: PFL1; cd01678 693444001847 coenzyme A binding site [chemical binding]; other site 693444001848 active site 693444001849 catalytic residues [active] 693444001850 glycine loop; other site 693444001851 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 693444001852 homotrimer interaction site [polypeptide binding]; other site 693444001853 putative active site [active] 693444001854 L-serine dehydratase TdcG; Provisional; Region: PRK15040 693444001855 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 693444001856 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 693444001857 Pirin-related protein [General function prediction only]; Region: COG1741 693444001858 Pirin; Region: Pirin; pfam02678 693444001859 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693444001860 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 693444001861 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 693444001862 dimerization interface [polypeptide binding]; other site 693444001863 Predicted membrane protein [Function unknown]; Region: COG3152 693444001864 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 693444001865 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 693444001866 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 693444001867 putative dimer interface [polypeptide binding]; other site 693444001868 N-terminal domain interface [polypeptide binding]; other site 693444001869 putative substrate binding pocket (H-site) [chemical binding]; other site 693444001870 Predicted membrane protein [Function unknown]; Region: COG2259 693444001871 hypothetical protein; Provisional; Region: PRK09956 693444001872 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 693444001873 YqjK-like protein; Region: YqjK; pfam13997 693444001874 Predicted membrane protein [Function unknown]; Region: COG5393 693444001875 Uncharacterized conserved protein [Function unknown]; Region: ElaB; COG4575 693444001876 Protein of unknown function (DUF1090); Region: DUF1090; pfam06476 693444001877 EnvZ/OmpR regulon moderator; Provisional; Region: PRK10629 693444001878 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 693444001879 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 693444001880 DNA-binding transcriptional repressor ExuR; Provisional; Region: PRK11523 693444001881 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 693444001882 DNA-binding site [nucleotide binding]; DNA binding site 693444001883 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 693444001884 D-galactonate transporter; Region: 2A0114; TIGR00893 693444001885 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693444001886 putative substrate translocation pore; other site 693444001887 Glucuronate isomerase; Region: UxaC; pfam02614 693444001888 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 693444001889 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 693444001890 galactarate dehydratase; Region: galactar-dH20; TIGR03248 693444001891 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 693444001892 Bacterial inner membrane protein; Region: Imp-YgjV; pfam10688 693444001893 serine/threonine transporter SstT; Provisional; Region: PRK13628 693444001894 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 693444001895 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 693444001896 yybP-ykoY leader; D782_0601; IMG reference gene:2507515298 693444001897 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 693444001898 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 693444001899 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 693444001900 putative active site [active] 693444001901 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451 693444001902 SAM-dependent 23S ribosomal RNA mG1835 methyltransferase; Provisional; Region: PRK15001 693444001903 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693444001904 S-adenosylmethionine binding site [chemical binding]; other site 693444001905 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 693444001906 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 693444001907 active site 693444001908 FMN binding site [chemical binding]; other site 693444001909 2,4-decadienoyl-CoA binding site; other site 693444001910 catalytic residue [active] 693444001911 4Fe-4S cluster binding site [ion binding]; other site 693444001912 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 693444001913 putrescine--2-oxoglutarate aminotransferase; Provisional; Region: PRK11522 693444001914 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 693444001915 inhibitor-cofactor binding pocket; inhibition site 693444001916 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693444001917 catalytic residue [active] 693444001918 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 693444001919 PAS fold; Region: PAS_3; pfam08447 693444001920 putative active site [active] 693444001921 heme pocket [chemical binding]; other site 693444001922 HAMP domain; Region: HAMP; pfam00672 693444001923 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 693444001924 dimer interface [polypeptide binding]; other site 693444001925 putative CheW interface [polypeptide binding]; other site 693444001926 Predicted transcriptional regulators [Transcription]; Region: COG1695 693444001927 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 693444001928 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 693444001929 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 693444001930 FAD binding pocket [chemical binding]; other site 693444001931 FAD binding motif [chemical binding]; other site 693444001932 phosphate binding motif [ion binding]; other site 693444001933 NAD binding pocket [chemical binding]; other site 693444001934 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 693444001935 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 693444001936 Walker A/P-loop; other site 693444001937 ATP binding site [chemical binding]; other site 693444001938 Q-loop/lid; other site 693444001939 ABC transporter signature motif; other site 693444001940 Walker B; other site 693444001941 D-loop; other site 693444001942 H-loop/switch region; other site 693444001943 NIL domain; Region: NIL; pfam09383 693444001944 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693444001945 dimer interface [polypeptide binding]; other site 693444001946 conserved gate region; other site 693444001947 putative PBP binding loops; other site 693444001948 ABC-ATPase subunit interface; other site 693444001949 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 693444001950 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 693444001951 Disulphide bond corrector protein DsbC; Region: DsbC; cl15830 693444001952 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 693444001953 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 693444001954 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 693444001955 DsbD alpha interface [polypeptide binding]; other site 693444001956 catalytic residues [active] 693444001957 conjugal transfer protein TrbB; Provisional; Region: PRK13728; cl17283 693444001958 DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023 693444001959 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 693444001960 catalytic residues [active] 693444001961 TlpA-like family, suppressor for copper sensitivity D protein (ScsD) and actinobacterial DsbE homolog subfamily; composed of ScsD, the DsbE homolog of Mycobacterium tuberculosis (MtbDsbE) and similar proteins, all containing a redox-active CXXC motif; Region: TlpA_like_ScsD_MtbDsbE; cd03011 693444001962 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 693444001963 catalytic residues [active] 693444001964 Spore Coat Protein U domain; Region: SCPU; pfam05229 693444001965 Spore Coat Protein U domain; Region: SCPU; pfam05229 693444001966 PapC N-terminal domain; Region: PapC_N; pfam13954 693444001967 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 693444001968 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 693444001969 PapC C-terminal domain; Region: PapC_C; pfam13953 693444001970 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 693444001971 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 693444001972 Spore Coat Protein U domain; Region: SCPU; cl02253 693444001973 Domain of unknown function (DUF1889); Region: DUF1889; pfam08986 693444001974 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 693444001975 active site 693444001976 SUMO-1 interface [polypeptide binding]; other site 693444001977 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 693444001978 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 693444001979 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 693444001980 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 693444001981 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 693444001982 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 693444001983 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 693444001984 DNA binding residues [nucleotide binding] 693444001985 DNA primase; Validated; Region: dnaG; PRK05667 693444001986 CHC2 zinc finger; Region: zf-CHC2; pfam01807 693444001987 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 693444001988 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 693444001989 active site 693444001990 metal binding site [ion binding]; metal-binding site 693444001991 interdomain interaction site; other site 693444001992 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 693444001993 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278 693444001994 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 693444001995 UGMP family protein; Validated; Region: PRK09604 693444001996 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 693444001997 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 693444001998 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 693444001999 homooctamer interface [polypeptide binding]; other site 693444002000 active site 693444002001 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 693444002002 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 693444002003 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 693444002004 active site 693444002005 NTP binding site [chemical binding]; other site 693444002006 metal binding triad [ion binding]; metal-binding site 693444002007 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 693444002008 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 693444002009 Zn2+ binding site [ion binding]; other site 693444002010 Mg2+ binding site [ion binding]; other site 693444002011 Bacterial SH3 domain homologues; Region: SH3b; smart00287 693444002012 SH3 domain protein; Region: SH3_and_anchor; TIGR04211 693444002013 Uncharacterized conserved protein [Function unknown]; Region: COG3025 693444002014 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 693444002015 putative active site [active] 693444002016 putative metal binding residues [ion binding]; other site 693444002017 signature motif; other site 693444002018 putative triphosphate binding site [ion binding]; other site 693444002019 CHAD domain; Region: CHAD; pfam05235 693444002020 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 693444002021 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 693444002022 metal binding triad; other site 693444002023 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 693444002024 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 693444002025 metal binding triad; other site 693444002026 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 693444002027 bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316 693444002028 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 693444002029 putative ribose interaction site [chemical binding]; other site 693444002030 putative ADP binding site [chemical binding]; other site 693444002031 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 693444002032 active site 693444002033 nucleotide binding site [chemical binding]; other site 693444002034 HIGH motif; other site 693444002035 KMSKS motif; other site 693444002036 Glycogen synthesis protein; Region: GlgS; cl11663 693444002037 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2960 693444002038 3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353 693444002039 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 693444002040 Fimbrial protein; Region: Fimbrial; pfam00419 693444002041 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 693444002042 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 693444002043 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 693444002044 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 693444002045 PapC N-terminal domain; Region: PapC_N; pfam13954 693444002046 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 693444002047 PapC C-terminal domain; Region: PapC_C; pfam13953 693444002048 Fimbrial protein; Region: Fimbrial; cl01416 693444002049 zinc transporter ZupT; Provisional; Region: PRK04201 693444002050 ZIP Zinc transporter; Region: Zip; pfam02535 693444002051 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 693444002052 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 693444002053 putative active site [active] 693444002054 metal binding site [ion binding]; metal-binding site 693444002055 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 693444002056 hypothetical protein; Provisional; Region: PRK11653 693444002057 outer membrane channel protein; Reviewed; Region: tolC; PRK09465 693444002058 ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729 693444002059 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 693444002060 dimer interface [polypeptide binding]; other site 693444002061 ADP-ribose binding site [chemical binding]; other site 693444002062 active site 693444002063 nudix motif; other site 693444002064 metal binding site [ion binding]; metal-binding site 693444002065 putative dehydrogenase; Provisional; Region: PRK11039 693444002066 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 693444002067 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 693444002068 active site 693444002069 metal binding site [ion binding]; metal-binding site 693444002070 hexamer interface [polypeptide binding]; other site 693444002071 esterase YqiA; Provisional; Region: PRK11071 693444002072 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 693444002073 DNA topoisomerase IV, B subunit, proteobacterial; Region: parE_Gneg; TIGR01055 693444002074 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693444002075 ATP binding site [chemical binding]; other site 693444002076 Mg2+ binding site [ion binding]; other site 693444002077 G-X-G motif; other site 693444002078 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 693444002079 anchoring element; other site 693444002080 dimer interface [polypeptide binding]; other site 693444002081 ATP binding site [chemical binding]; other site 693444002082 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 693444002083 active site 693444002084 metal binding site [ion binding]; metal-binding site 693444002085 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 693444002086 Cupin domain; Region: Cupin_2; pfam07883 693444002087 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 693444002088 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 693444002089 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 693444002090 Uncharacterized protein conserved in bacteria (DUF2264); Region: DUF2264; pfam10022 693444002091 galactoside permease; Reviewed; Region: lacY; PRK09528 693444002092 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693444002093 putative substrate translocation pore; other site 693444002094 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 693444002095 Uncharacterized conserved protein [Function unknown]; Region: COG1359 693444002096 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 693444002097 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 693444002098 sensor protein QseC; Provisional; Region: PRK10337 693444002099 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 693444002100 dimer interface [polypeptide binding]; other site 693444002101 phosphorylation site [posttranslational modification] 693444002102 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693444002103 ATP binding site [chemical binding]; other site 693444002104 Mg2+ binding site [ion binding]; other site 693444002105 G-X-G motif; other site 693444002106 DNA-binding transcriptional regulator QseB; Provisional; Region: PRK10336 693444002107 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693444002108 active site 693444002109 phosphorylation site [posttranslational modification] 693444002110 intermolecular recognition site; other site 693444002111 dimerization interface [polypeptide binding]; other site 693444002112 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 693444002113 DNA binding site [nucleotide binding] 693444002114 Periplasmic protein with OB-fold [Function unknown]; Region: COG3111 693444002115 DNA gyrase inhibitor [DNA replication, recombination, and repair]; Region: COG3449 693444002116 DNA topoisomerase IV, A subunit, proteobacterial; Region: parC_Gneg; TIGR01062 693444002117 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 693444002118 CAP-like domain; other site 693444002119 active site 693444002120 primary dimer interface [polypeptide binding]; other site 693444002121 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 693444002122 1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional; Region: PRK15018 693444002123 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 693444002124 putative acyl-acceptor binding pocket; other site 693444002125 FtsI repressor; Provisional; Region: PRK10883 693444002126 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 693444002127 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 693444002128 heat shock protein HtpX; Provisional; Region: PRK04897 693444002129 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 693444002130 putative mechanosensitive channel protein; Provisional; Region: PRK10929 693444002131 hypothetical protein; Provisional; Region: PRK01254 693444002132 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 693444002133 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 693444002134 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 693444002135 nucleotide binding site/active site [active] 693444002136 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 693444002137 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 693444002138 transmembrane helices; other site 693444002139 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 693444002140 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 693444002141 active site 693444002142 catalytic tetrad [active] 693444002143 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 693444002144 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 693444002145 dimer interface [polypeptide binding]; other site 693444002146 active site 693444002147 metal binding site [ion binding]; metal-binding site 693444002148 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 693444002149 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 693444002150 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 693444002151 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 693444002152 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 693444002153 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 693444002154 cystathionine beta-lyase; Provisional; Region: PRK08114 693444002155 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 693444002156 homodimer interface [polypeptide binding]; other site 693444002157 substrate-cofactor binding pocket; other site 693444002158 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693444002159 catalytic residue [active] 693444002160 biopolymer transport protein ExbB; Provisional; Region: PRK10414 693444002161 biopolymer transport protein ExbD; Provisional; Region: PRK11267 693444002162 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 693444002163 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 693444002164 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 693444002165 dimer interface [polypeptide binding]; other site 693444002166 putative CheW interface [polypeptide binding]; other site 693444002167 hypothetical protein; Provisional; Region: PRK05208 693444002168 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 693444002169 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 693444002170 active site 693444002171 catalytic tetrad [active] 693444002172 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 693444002173 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 693444002174 Protein of unknown function (DUF2623); Region: DUF2623; pfam11115 693444002175 putative S-transferase; Provisional; Region: PRK11752 693444002176 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 693444002177 C-terminal domain interface [polypeptide binding]; other site 693444002178 GSH binding site (G-site) [chemical binding]; other site 693444002179 dimer interface [polypeptide binding]; other site 693444002180 C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292 693444002181 dimer interface [polypeptide binding]; other site 693444002182 N-terminal domain interface [polypeptide binding]; other site 693444002183 active site 693444002184 bifunctional glutathionylspermidine amidase/glutathionylspermidine synthetase; Provisional; Region: PRK10507 693444002185 CHAP domain; Region: CHAP; pfam05257 693444002186 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 693444002187 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 693444002188 The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489 693444002189 substrate binding site [chemical binding]; other site 693444002190 nickel transporter permease NikB; Provisional; Region: PRK10352 693444002191 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693444002192 dimer interface [polypeptide binding]; other site 693444002193 conserved gate region; other site 693444002194 putative PBP binding loops; other site 693444002195 ABC-ATPase subunit interface; other site 693444002196 nickel transporter permease NikC; Provisional; Region: nikC; PRK10417 693444002197 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693444002198 dimer interface [polypeptide binding]; other site 693444002199 conserved gate region; other site 693444002200 putative PBP binding loops; other site 693444002201 ABC-ATPase subunit interface; other site 693444002202 nickel transporter ATP-binding protein NikD; Provisional; Region: nikD; PRK10418 693444002203 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 693444002204 Walker A/P-loop; other site 693444002205 ATP binding site [chemical binding]; other site 693444002206 Q-loop/lid; other site 693444002207 ABC transporter signature motif; other site 693444002208 Walker B; other site 693444002209 D-loop; other site 693444002210 H-loop/switch region; other site 693444002211 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 693444002212 nickel transporter ATP-binding protein NikE; Provisional; Region: nikE; PRK10419 693444002213 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 693444002214 Walker A/P-loop; other site 693444002215 ATP binding site [chemical binding]; other site 693444002216 Q-loop/lid; other site 693444002217 ABC transporter signature motif; other site 693444002218 Walker B; other site 693444002219 D-loop; other site 693444002220 H-loop/switch region; other site 693444002221 nickel responsive regulator; Provisional; Region: PRK02967 693444002222 NikR C terminal nickel binding domain; Region: NikR_C; pfam08753 693444002223 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 693444002224 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 693444002225 PapC N-terminal domain; Region: PapC_N; pfam13954 693444002226 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 693444002227 PapC C-terminal domain; Region: PapC_C; pfam13953 693444002228 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 693444002229 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 693444002230 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 693444002231 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 693444002232 Fimbrial protein; Region: Fimbrial; cl01416 693444002233 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 693444002234 putative fimbrial outer membrane usher protein StfC; Provisional; Region: PRK15284 693444002235 PapC N-terminal domain; Region: PapC_N; pfam13954 693444002236 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 693444002237 PapC C-terminal domain; Region: PapC_C; pfam13953 693444002238 putative fimbrial chaperone protein StfD; Provisional; Region: PRK15285 693444002239 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 693444002240 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 693444002241 Fimbrial protein; Region: Fimbrial; cl01416 693444002242 Fimbrial protein; Region: Fimbrial; pfam00419 693444002243 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 693444002244 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 693444002245 hypothetical protein; Provisional; Region: PRK09867 693444002246 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 693444002247 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693444002248 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator CynR, contains the type 2 periplasmic binding fold; Region: PBP2_CynR; cd08425 693444002249 dimerization interface [polypeptide binding]; other site 693444002250 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 693444002251 active site clefts [active] 693444002252 zinc binding site [ion binding]; other site 693444002253 dimer interface [polypeptide binding]; other site 693444002254 cyanate hydratase; Validated; Region: PRK02866 693444002255 Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate. It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559 693444002256 oligomer interface [polypeptide binding]; other site 693444002257 active site 693444002258 putative cyanate transporter; Provisional; Region: cynX; PRK09705 693444002259 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693444002260 Protein of unknown function (DUF554); Region: DUF554; pfam04474 693444002261 ornithine decarboxylase; Provisional; Region: PRK13578 693444002262 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 693444002263 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 693444002264 homodimer interface [polypeptide binding]; other site 693444002265 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693444002266 catalytic residue [active] 693444002267 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 693444002268 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 693444002269 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693444002270 active site 693444002271 phosphorylation site [posttranslational modification] 693444002272 intermolecular recognition site; other site 693444002273 dimerization interface [polypeptide binding]; other site 693444002274 Transcriptional regulator; Region: CitT; pfam12431 693444002275 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 693444002276 PAS domain; Region: PAS; smart00091 693444002277 putative active site [active] 693444002278 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693444002279 ATP binding site [chemical binding]; other site 693444002280 Mg2+ binding site [ion binding]; other site 693444002281 G-X-G motif; other site 693444002282 2-hydroxycarboxylate transporter family; Region: 2HCT; pfam03390 693444002283 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 693444002284 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 693444002285 Citrate lyase synthetase [Energy production and conversion]; Region: CitC; COG3053 693444002286 Citrate lyase ligase; Region: Citrate_lyase_ligase; cd02169 693444002287 putative active site [active] 693444002288 (T/H)XGH motif; other site 693444002289 citrate lyase subunit gamma; Provisional; Region: PRK13253 693444002290 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 693444002291 Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051 693444002292 Coenzyme A transferase; Region: CoA_trans; cl17247 693444002293 Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase; Region: CitX; pfam03802 693444002294 ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; cl00768 693444002295 murein transglycosylase C; Provisional; Region: mltC; PRK11671 693444002296 Domain of unknown function (DUF3393); Region: DUF3393; pfam11873 693444002297 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 693444002298 N-acetyl-D-glucosamine binding site [chemical binding]; other site 693444002299 catalytic residue [active] 693444002300 oxidative damage protection protein; Provisional; Region: PRK05408 693444002301 adenine DNA glycosylase; Provisional; Region: PRK10880 693444002302 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 693444002303 minor groove reading motif; other site 693444002304 helix-hairpin-helix signature motif; other site 693444002305 substrate binding pocket [chemical binding]; other site 693444002306 active site 693444002307 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 693444002308 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 693444002309 DNA binding and oxoG recognition site [nucleotide binding] 693444002310 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 693444002311 hypothetical protein; Provisional; Region: PRK11702 693444002312 hypothetical protein; Provisional; Region: PRK10626 693444002313 Protein of unknown function (DUF2884); Region: DUF2884; pfam11101 693444002314 Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038 693444002315 putative active site [active] 693444002316 Protein of unknown function (DUF1202); Region: DUF1202; pfam06717 693444002317 Bacterial L-asparaginases and related enzymes; Region: L-asparaginase_like; cd00411 693444002318 active site 693444002319 homodimer interface [polypeptide binding]; other site 693444002320 HemN family oxidoreductase; Provisional; Region: PRK05660 693444002321 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 693444002322 FeS/SAM binding site; other site 693444002323 HemN C-terminal domain; Region: HemN_C; pfam06969 693444002324 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 693444002325 active site 693444002326 dimerization interface [polypeptide binding]; other site 693444002327 hypothetical protein; Validated; Region: PRK05090 693444002328 YGGT family; Region: YGGT; pfam02325 693444002329 Predicted integral membrane protein [Function unknown]; Region: COG0762 693444002330 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 693444002331 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 693444002332 catalytic residue [active] 693444002333 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 693444002334 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 693444002335 Walker A motif; other site 693444002336 ATP binding site [chemical binding]; other site 693444002337 Walker B motif; other site 693444002338 DNA-binding transcriptional regulator CsgD; Provisional; Region: PRK10100 693444002339 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 693444002340 DNA binding residues [nucleotide binding] 693444002341 dimerization interface [polypeptide binding]; other site 693444002342 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 693444002343 hypothetical protein; Validated; Region: PRK00228 693444002344 glutathione synthetase; Provisional; Region: PRK05246 693444002345 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 693444002346 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 693444002347 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 693444002348 RNA methyltransferase, RsmE family; Region: TIGR00046 693444002349 DNA-specific endonuclease I; Provisional; Region: PRK15137 693444002350 Endonuclease I [DNA replication, recombination, and repair]; Region: EndA; COG2356 693444002351 hypothetical protein; Provisional; Region: PRK04860 693444002352 Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091 693444002353 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 693444002354 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693444002355 putative substrate translocation pore; other site 693444002356 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693444002357 S-adenosylmethionine synthetase; Validated; Region: PRK05250 693444002358 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 693444002359 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 693444002360 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 693444002361 Arginine decarboxylase (spermidine biosynthesis) [Amino acid transport and metabolism]; Region: SpeA; COG1166 693444002362 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 693444002363 dimer interface [polypeptide binding]; other site 693444002364 active site 693444002365 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 693444002366 catalytic residues [active] 693444002367 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 693444002368 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 693444002369 agmatinase; Region: agmatinase; TIGR01230 693444002370 oligomer interface [polypeptide binding]; other site 693444002371 putative active site [active] 693444002372 Mn binding site [ion binding]; other site 693444002373 Major Facilitator Superfamily; Region: MFS_1; pfam07690 693444002374 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693444002375 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 693444002376 [2Fe-2S] cluster binding site [ion binding]; other site 693444002377 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 693444002378 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 693444002379 [2Fe-2S] cluster binding site [ion binding]; other site 693444002380 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 693444002381 hydrophobic ligand binding site; other site 693444002382 short chain dehydrogenase; Provisional; Region: PRK12939 693444002383 classical (c) SDRs; Region: SDR_c; cd05233 693444002384 NAD(P) binding site [chemical binding]; other site 693444002385 active site 693444002386 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 693444002387 Transcriptional regulator [Transcription]; Region: IclR; COG1414 693444002388 Bacterial transcriptional regulator; Region: IclR; pfam01614 693444002389 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 693444002390 active site 693444002391 metal binding site [ion binding]; metal-binding site 693444002392 C-terminal domain of Burkholderia sp. NF100 MhqB and similar proteins; MhqB is a type I extradiol dioxygenase involved in the catabolism of methylhydroquinone, an intermediate in the degradation of fenitrothion; Region: MhqB_like_C; cd08360 693444002393 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 693444002394 putative active site [active] 693444002395 putative metal binding site [ion binding]; other site 693444002396 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 693444002397 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 693444002398 D-galactonate transporter; Region: 2A0114; TIGR00893 693444002399 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693444002400 putative substrate translocation pore; other site 693444002401 Cupin domain; Region: Cupin_2; pfam07883 693444002402 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 693444002403 short chain dehydrogenase; Provisional; Region: PRK07062 693444002404 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 693444002405 NAD(P) binding site [chemical binding]; other site 693444002406 active site 693444002407 L-aspartate dehydrogenase; Provisional; Region: PRK13303 693444002408 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 693444002409 Domain of unknown function DUF108; Region: DUF108; pfam01958 693444002410 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 693444002411 Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114 693444002412 NAD(P) binding site [chemical binding]; other site 693444002413 catalytic residues [active] 693444002414 hypothetical protein; Provisional; Region: PRK07064 693444002415 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 693444002416 PYR/PP interface [polypeptide binding]; other site 693444002417 dimer interface [polypeptide binding]; other site 693444002418 TPP binding site [chemical binding]; other site 693444002419 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 693444002420 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 693444002421 TPP-binding site [chemical binding]; other site 693444002422 outer membrane porin, OprD family; Region: OprD; pfam03573 693444002423 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 693444002424 transketolase; Reviewed; Region: PRK12753 693444002425 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 693444002426 TPP-binding site [chemical binding]; other site 693444002427 dimer interface [polypeptide binding]; other site 693444002428 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 693444002429 PYR/PP interface [polypeptide binding]; other site 693444002430 dimer interface [polypeptide binding]; other site 693444002431 TPP binding site [chemical binding]; other site 693444002432 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 693444002433 erythrose 4-phosphate dehydrogenase; Provisional; Region: PRK13535 693444002434 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 693444002435 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 693444002436 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 693444002437 Phosphoglycerate kinase; Region: PGK; pfam00162 693444002438 substrate binding site [chemical binding]; other site 693444002439 hinge regions; other site 693444002440 ADP binding site [chemical binding]; other site 693444002441 catalytic site [active] 693444002442 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 693444002443 Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946 693444002444 active site 693444002445 intersubunit interface [polypeptide binding]; other site 693444002446 zinc binding site [ion binding]; other site 693444002447 Na+ binding site [ion binding]; other site 693444002448 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 693444002449 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 693444002450 putative substrate binding site [chemical binding]; other site 693444002451 nucleotide binding site [chemical binding]; other site 693444002452 nucleotide binding site [chemical binding]; other site 693444002453 homodimer interface [polypeptide binding]; other site 693444002454 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693444002455 D-galactonate transporter; Region: 2A0114; TIGR00893 693444002456 putative substrate translocation pore; other site 693444002457 membrane protein FdrA; Validated; Region: PRK06091 693444002458 CoA binding domain; Region: CoA_binding; pfam02629 693444002459 CoA-ligase; Region: Ligase_CoA; pfam00549 693444002460 Protein of unknown function (DUF1116); Region: DUF1116; pfam06545 693444002461 Protein of unknown function (DUF2877); Region: DUF2877; pfam11392 693444002462 DNA-binding transcriptional activator AllS; Provisional; Region: PRK10094 693444002463 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693444002464 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 693444002465 dimerization interface [polypeptide binding]; other site 693444002466 mechanosensitive channel MscS; Provisional; Region: PRK10334 693444002467 Mechanosensitive ion channel; Region: MS_channel; pfam00924 693444002468 arginine exporter protein; Provisional; Region: PRK09304 693444002469 Uncharacterized conserved protein [Function unknown]; Region: COG2968 693444002470 oxidative stress defense protein; Provisional; Region: PRK11087 693444002471 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 693444002472 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693444002473 The C-terminal substrate binding domain of LysR-type transcriptional regulator, ArgP (IciA), for arginine exporter (ArgO); contains the type 2 periplasmic binding fold; Region: PBP2_IciA_ArgP; cd08428 693444002474 putative dimerization interface [polypeptide binding]; other site 693444002475 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 693444002476 tetramer (dimer of dimers) interface [polypeptide binding]; other site 693444002477 active site 693444002478 dimer interface [polypeptide binding]; other site 693444002479 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 693444002480 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 693444002481 ligand binding site [chemical binding]; other site 693444002482 NAD binding site [chemical binding]; other site 693444002483 tetramer interface [polypeptide binding]; other site 693444002484 catalytic site [active] 693444002485 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 693444002486 L-serine binding site [chemical binding]; other site 693444002487 ACT domain interface; other site 693444002488 5-formyltetrahydrofolate cyclo-ligase family protein; Provisional; Region: PRK10333 693444002489 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 693444002490 Z-ring-associated protein; Provisional; Region: PRK10972 693444002491 hypothetical protein; Reviewed; Region: PRK01736 693444002492 proline aminopeptidase P II; Provisional; Region: PRK10879 693444002493 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 693444002494 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 693444002495 active site 693444002496 2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK05732 693444002497 2-polyprenyl-6-methoxyphenol 4-hydroxylase; Region: UbiH; TIGR01984 693444002498 oxidoreductase; Provisional; Region: PRK08013 693444002499 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 693444002500 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 693444002501 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 693444002502 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 693444002503 lipoyl attachment site [posttranslational modification]; other site 693444002504 glycine dehydrogenase; Provisional; Region: PRK05367 693444002505 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 693444002506 tetramer interface [polypeptide binding]; other site 693444002507 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693444002508 catalytic residue [active] 693444002509 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 693444002510 tetramer interface [polypeptide binding]; other site 693444002511 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693444002512 catalytic residue [active] 693444002513 putative NAD(P)-binding oxidoreductase; Provisional; Region: PRK09730 693444002514 classical (c) SDRs; Region: SDR_c; cd05233 693444002515 NAD(P) binding site [chemical binding]; other site 693444002516 active site 693444002517 6-phospho-beta-glucosidase BglA; Provisional; Region: PRK15014 693444002518 beta-galactosidase; Region: BGL; TIGR03356 693444002519 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 693444002520 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 693444002521 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 693444002522 putative active site [active] 693444002523 ASC-1 homology domain, subfamily similar to Escherichia coli Yqfb. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as...; Region: ASCH_yqfb_like; cd06552 693444002524 hemolysin; Provisional; Region: PRK15087 693444002525 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 693444002526 putative global regulator; Reviewed; Region: PRK09559 693444002527 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 693444002528 hypothetical protein; Provisional; Region: PRK10878 693444002529 Protein of unknown function (DUF1434); Region: DUF1434; pfam07254 693444002530 flavodoxin FldB; Provisional; Region: PRK12359 693444002531 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 693444002532 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 693444002533 active site 693444002534 Int/Topo IB signature motif; other site 693444002535 protein disulfide isomerase II DsbC; Provisional; Region: PRK10877 693444002536 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 693444002537 dimerization domain [polypeptide binding]; other site 693444002538 dimer interface [polypeptide binding]; other site 693444002539 catalytic residues [active] 693444002540 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 693444002541 DHH family; Region: DHH; pfam01368 693444002542 DHHA1 domain; Region: DHHA1; pfam02272 693444002543 peptide chain release factor 2; Validated; Region: prfB; PRK00578 693444002544 This domain is found in peptide chain release factors; Region: PCRF; smart00937 693444002545 RF-1 domain; Region: RF-1; pfam00472 693444002546 lysyl-tRNA synthetase; Reviewed; Region: PRK12445 693444002547 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 693444002548 dimer interface [polypeptide binding]; other site 693444002549 putative anticodon binding site; other site 693444002550 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 693444002551 motif 1; other site 693444002552 active site 693444002553 motif 2; other site 693444002554 motif 3; other site 693444002555 Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443 693444002556 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 693444002557 active site 693444002558 metal binding site [ion binding]; metal-binding site 693444002559 nudix motif; other site 693444002560 Protein of unknown function (DUF554); Region: DUF554; pfam04474 693444002561 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 693444002562 Flavoprotein; Region: Flavoprotein; pfam02441 693444002563 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; pfam01977 693444002564 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693444002565 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693444002566 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 693444002567 dimerization interface [polypeptide binding]; other site 693444002568 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 693444002569 Peptidase family M23; Region: Peptidase_M23; pfam01551 693444002570 hypothetical protein; Provisional; Region: PRK09897 693444002571 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 693444002572 ferric-rhodotorulic acid outer membrane transporter; Provisional; Region: PRK10003 693444002573 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 693444002574 N-terminal plug; other site 693444002575 ligand-binding site [chemical binding]; other site 693444002576 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693444002577 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693444002578 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 693444002579 putative effector binding pocket; other site 693444002580 putative dimerization interface [polypeptide binding]; other site 693444002581 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 693444002582 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693444002583 putative substrate translocation pore; other site 693444002584 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 693444002585 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 693444002586 Protein of unknown function (DUF1398); Region: DUF1398; cl11576 693444002587 holo-(acyl carrier protein) synthase 2; Provisional; Region: PRK10351 693444002588 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 693444002589 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK09116 693444002590 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 693444002591 dimer interface [polypeptide binding]; other site 693444002592 active site 693444002593 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 693444002594 3-oxoacyl-(acyl-carrier-protein) reductase, putative; Region: fabG_rel; TIGR01831 693444002595 NAD(P) binding site [chemical binding]; other site 693444002596 active site 693444002597 Domain of unknown function, appears to be related to a diverse group of beta-hydroxydecanoyl ACP dehydratases (FabA) and beta-hydroxyacyl ACP dehydratases (FabZ). This group appears to lack the conserved active site histidine of FabA and FabZ; Region: FabA_like; cd01289 693444002598 putative active site 1 [active] 693444002599 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK09185 693444002600 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 693444002601 dimer interface [polypeptide binding]; other site 693444002602 active site 693444002603 Protein of unknown function (DUF3261); Region: DUF3261; pfam11659 693444002604 Predicted exporter [General function prediction only]; Region: COG4258 693444002605 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 693444002606 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 693444002607 active site 693444002608 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 693444002609 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 693444002610 Ligand binding site; other site 693444002611 Putative Catalytic site; other site 693444002612 DXD motif; other site 693444002613 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 693444002614 putative acyl-acceptor binding pocket; other site 693444002615 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 693444002616 active site 2 [active] 693444002617 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 693444002618 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 693444002619 AMP binding site [chemical binding]; other site 693444002620 active site 693444002621 acyl-activating enzyme (AAE) consensus motif; other site 693444002622 CoA binding site [chemical binding]; other site 693444002623 Predicted membrane protein [Function unknown]; Region: COG4648 693444002624 acyl carrier protein; Provisional; Region: PRK05350 693444002625 Phosphopantetheine attachment site; Region: PP-binding; cl09936 693444002626 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 693444002627 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 693444002628 putative acyl-acceptor binding pocket; other site 693444002629 Beta-ketoacyl synthase, N-terminal domain; Region: Ketoacyl-synt_2; pfam13723 693444002630 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 693444002631 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 693444002632 Predicted membrane protein [Function unknown]; Region: COG4125 693444002633 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 693444002634 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 693444002635 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693444002636 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693444002637 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 693444002638 dimerization interface [polypeptide binding]; other site 693444002639 putative acyltransferase; Provisional; Region: PRK05790 693444002640 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 693444002641 dimer interface [polypeptide binding]; other site 693444002642 active site 693444002643 Oligogalacturonate-specific porin protein (KdgM); Region: KdgM; cl11629 693444002644 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 693444002645 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 693444002646 2-deoxy-D-gluconate 3-dehydrogenase; Validated; Region: PRK08993 693444002647 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 693444002648 NADP binding site [chemical binding]; other site 693444002649 homodimer interface [polypeptide binding]; other site 693444002650 active site 693444002651 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 693444002652 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693444002653 putative substrate translocation pore; other site 693444002654 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693444002655 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 693444002656 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 693444002657 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 693444002658 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 693444002659 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 693444002660 Walker A/P-loop; other site 693444002661 ATP binding site [chemical binding]; other site 693444002662 Q-loop/lid; other site 693444002663 ABC transporter signature motif; other site 693444002664 Walker B; other site 693444002665 D-loop; other site 693444002666 H-loop/switch region; other site 693444002667 TOBE domain; Region: TOBE; pfam03459 693444002668 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 693444002669 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693444002670 dimer interface [polypeptide binding]; other site 693444002671 conserved gate region; other site 693444002672 putative PBP binding loops; other site 693444002673 ABC-ATPase subunit interface; other site 693444002674 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693444002675 dimer interface [polypeptide binding]; other site 693444002676 conserved gate region; other site 693444002677 putative PBP binding loops; other site 693444002678 ABC-ATPase subunit interface; other site 693444002679 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 693444002680 putative racemase; Provisional; Region: PRK10200 693444002681 aspartate racemase; Region: asp_race; TIGR00035 693444002682 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 693444002683 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693444002684 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 693444002685 dimerization interface [polypeptide binding]; other site 693444002686 diaminopimelate decarboxylase; Provisional; Region: PRK11165 693444002687 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 693444002688 active site 693444002689 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 693444002690 substrate binding site [chemical binding]; other site 693444002691 catalytic residues [active] 693444002692 dimer interface [polypeptide binding]; other site 693444002693 Transcriptional regulators [Transcription]; Region: PurR; COG1609 693444002694 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 693444002695 DNA binding site [nucleotide binding] 693444002696 domain linker motif; other site 693444002697 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 693444002698 dimerization interface (closed form) [polypeptide binding]; other site 693444002699 ligand binding site [chemical binding]; other site 693444002700 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 693444002701 DNA-binding transcriptional regulator GalR; Provisional; Region: PRK10727 693444002702 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 693444002703 DNA binding site [nucleotide binding] 693444002704 domain linker motif; other site 693444002705 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 693444002706 dimerization interface (closed form) [polypeptide binding]; other site 693444002707 ligand binding site [chemical binding]; other site 693444002708 bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase; Validated; Region: PRK08043 693444002709 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 693444002710 putative acyl-acceptor binding pocket; other site 693444002711 C-terminal domain of the acyl-acyl carrier protein synthetase (also called 2-acylglycerophosphoethanolamine acyltransferase, Aas); Region: AAS_C; cd05909 693444002712 acyl-activating enzyme (AAE) consensus motif; other site 693444002713 putative AMP binding site [chemical binding]; other site 693444002714 lysophospholipid transporter LplT; Provisional; Region: PRK11195 693444002715 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693444002716 putative substrate translocation pore; other site 693444002717 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 693444002718 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 693444002719 active site 693444002720 catalytic tetrad [active] 693444002721 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 693444002722 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 693444002723 MutH is a 28kD endonuclease involved in methyl-directed DNA mismatch repair in gram negative bacteria. MutH is both sequence-specific and methylation-specific, introducing a nick in the unmethylated strand of a hemi-methylated d(GATC) DNA duplex. MutH...; Region: MutH_Sau3AI; cd00583 693444002724 putative DNA-binding cleft [nucleotide binding]; other site 693444002725 putative DNA clevage site; other site 693444002726 molecular lever; other site 693444002727 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 693444002728 putative active site [active] 693444002729 Ap4A binding site [chemical binding]; other site 693444002730 nudix motif; other site 693444002731 putative metal binding site [ion binding]; other site 693444002732 fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain; Provisional; Region: PRK11061 693444002733 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 693444002734 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 693444002735 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 693444002736 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 693444002737 phosphonoacetate hydrolase; Region: hydr_PhnA; TIGR02335 693444002738 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 693444002739 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 693444002740 thymidylate synthase; Reviewed; Region: thyA; PRK01827 693444002741 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 693444002742 dimerization interface [polypeptide binding]; other site 693444002743 active site 693444002744 hypothetical protein; Provisional; Region: PRK10506 693444002745 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 693444002746 hypothetical protein; Provisional; Region: PRK10557 693444002747 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 693444002748 Protein of unknown function (DUF2509); Region: DUF2509; cl11672 693444002749 hypothetical protein; Provisional; Region: PRK10332 693444002750 Prepilin peptidase dependent protein C term (DUF3728); Region: DUF3728; pfam12528 693444002751 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 693444002752 Exonuclease V gamma subunit [DNA replication, recombination, and repair]; Region: RecC; COG1330 693444002753 protease3; Provisional; Region: PRK15101 693444002754 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 693444002755 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 693444002756 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 693444002757 exonuclease V subunit beta; Provisional; Region: recB; PRK10876 693444002758 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 693444002759 exonuclease V subunit alpha; Provisional; Region: recD; PRK10875 693444002760 AAA domain; Region: AAA_30; pfam13604 693444002761 Family description; Region: UvrD_C_2; pfam13538 693444002762 N-acetylglutamate synthase; Validated; Region: PRK05279 693444002763 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 693444002764 putative feedback inhibition sensing region; other site 693444002765 putative nucleotide binding site [chemical binding]; other site 693444002766 putative substrate binding site [chemical binding]; other site 693444002767 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 693444002768 Coenzyme A binding pocket [chemical binding]; other site 693444002769 N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431 693444002770 AMIN domain; Region: AMIN; pfam11741 693444002771 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 693444002772 active site 693444002773 metal binding site [ion binding]; metal-binding site 693444002774 murein transglycosylase A; Provisional; Region: mltA; PRK11162 693444002775 murein hydrolase B; Provisional; Region: PRK10760; cl17906 693444002776 MltA specific insert domain; Region: MltA; pfam03562 693444002777 3D domain; Region: 3D; pfam06725 693444002778 sulfur acceptor protein CsdL; Provisional; Region: PRK15116 693444002779 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 693444002780 putative ATP binding site [chemical binding]; other site 693444002781 putative substrate interface [chemical binding]; other site 693444002782 Fe-S metabolism associated domain; Region: SufE; cl00951 693444002783 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 693444002784 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 693444002785 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 693444002786 catalytic residue [active] 693444002787 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 693444002788 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 693444002789 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693444002790 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 693444002791 dimerization interface [polypeptide binding]; other site 693444002792 substrate binding pocket [chemical binding]; other site 693444002793 hypothetical protein; Provisional; Region: PRK10873 693444002794 putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760 693444002795 FtsJ-like methyltransferase; Region: FtsJ; cl17430 693444002796 flap endonuclease-like protein; Provisional; Region: PRK09482 693444002797 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 693444002798 active site 693444002799 metal binding site 1 [ion binding]; metal-binding site 693444002800 putative 5' ssDNA interaction site; other site 693444002801 metal binding site 3; metal-binding site 693444002802 metal binding site 2 [ion binding]; metal-binding site 693444002803 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 693444002804 putative DNA binding site [nucleotide binding]; other site 693444002805 putative metal binding site [ion binding]; other site 693444002806 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 693444002807 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 693444002808 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 693444002809 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 693444002810 serine transporter; Region: stp; TIGR00814 693444002811 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 693444002812 Domain of unknown function (DUF3412); Region: DUF3412; pfam11892 693444002813 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904 693444002814 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 693444002815 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 693444002816 SecY interacting protein Syd; Provisional; Region: PRK04968 693444002817 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3098 693444002818 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 693444002819 tRNA pseudouridine isomerase C; Region: PseudoU_synth_TruC; cd02563 693444002820 probable active site [active] 693444002821 flavodoxin; Provisional; Region: PRK08105 693444002822 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693444002823 D-galactonate transporter; Region: 2A0114; TIGR00893 693444002824 putative substrate translocation pore; other site 693444002825 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 693444002826 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 693444002827 active site 693444002828 tetramer interface [polypeptide binding]; other site 693444002829 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 693444002830 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 693444002831 active site 693444002832 tetramer interface [polypeptide binding]; other site 693444002833 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 693444002834 hybrid sensory histidine kinase BarA; Provisional; Region: PRK11107 693444002835 Uncharacterized signal transduction histidine kinase domain (DUF2222); Region: DUF2222; pfam09984 693444002836 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 693444002837 dimerization interface [polypeptide binding]; other site 693444002838 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 693444002839 dimer interface [polypeptide binding]; other site 693444002840 phosphorylation site [posttranslational modification] 693444002841 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693444002842 ATP binding site [chemical binding]; other site 693444002843 Mg2+ binding site [ion binding]; other site 693444002844 G-X-G motif; other site 693444002845 Uncharacterized domain of BarA-like signal transduction histidine kinases [Signal transduction mechanisms]; Region: COG4999 693444002846 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693444002847 active site 693444002848 phosphorylation site [posttranslational modification] 693444002849 intermolecular recognition site; other site 693444002850 dimerization interface [polypeptide binding]; other site 693444002851 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 693444002852 putative binding surface; other site 693444002853 active site 693444002854 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 693444002855 TRAM domain; Region: TRAM; pfam01938 693444002856 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693444002857 S-adenosylmethionine binding site [chemical binding]; other site 693444002858 (p)ppGpp synthetase I/GTP pyrophosphokinase; Provisional; Region: relA; PRK10872 693444002859 HD domain; Region: HD_4; pfam13328 693444002860 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 693444002861 synthetase active site [active] 693444002862 NTP binding site [chemical binding]; other site 693444002863 metal binding site [ion binding]; metal-binding site 693444002864 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 693444002865 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 693444002866 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 693444002867 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 693444002868 homodimer interface [polypeptide binding]; other site 693444002869 metal binding site [ion binding]; metal-binding site 693444002870 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 693444002871 homodimer interface [polypeptide binding]; other site 693444002872 active site 693444002873 putative chemical substrate binding site [chemical binding]; other site 693444002874 metal binding site [ion binding]; metal-binding site 693444002875 CTP synthetase; Validated; Region: pyrG; PRK05380 693444002876 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 693444002877 Catalytic site [active] 693444002878 active site 693444002879 UTP binding site [chemical binding]; other site 693444002880 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 693444002881 active site 693444002882 putative oxyanion hole; other site 693444002883 catalytic triad [active] 693444002884 enolase; Provisional; Region: eno; PRK00077 693444002885 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 693444002886 dimer interface [polypeptide binding]; other site 693444002887 metal binding site [ion binding]; metal-binding site 693444002888 substrate binding pocket [chemical binding]; other site 693444002889 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 693444002890 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 693444002891 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 693444002892 active site 693444002893 sulfite reductase subunit alpha; Provisional; Region: cysJ; PRK10953 693444002894 Flavodoxin; Region: Flavodoxin_1; pfam00258 693444002895 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 693444002896 FAD binding pocket [chemical binding]; other site 693444002897 FAD binding motif [chemical binding]; other site 693444002898 catalytic residues [active] 693444002899 NAD binding pocket [chemical binding]; other site 693444002900 phosphate binding motif [ion binding]; other site 693444002901 beta-alpha-beta structure motif; other site 693444002902 sulfite reductase subunit beta; Provisional; Region: PRK13504 693444002903 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 693444002904 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 693444002905 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 693444002906 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 693444002907 Active Sites [active] 693444002908 Hok/gef family; Region: HOK_GEF; pfam01848 693444002909 alkaline phosphatase isozyme conversion aminopeptidase; Provisional; Region: PRK10199 693444002910 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 693444002911 metal binding site [ion binding]; metal-binding site 693444002912 siroheme synthase; Provisional; Region: cysG; PRK10637 693444002913 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 693444002914 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 693444002915 active site 693444002916 SAM binding site [chemical binding]; other site 693444002917 homodimer interface [polypeptide binding]; other site 693444002918 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 693444002919 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 693444002920 Active Sites [active] 693444002921 sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124 693444002922 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 693444002923 CysD dimerization site [polypeptide binding]; other site 693444002924 G1 box; other site 693444002925 putative GEF interaction site [polypeptide binding]; other site 693444002926 GTP/Mg2+ binding site [chemical binding]; other site 693444002927 Switch I region; other site 693444002928 G2 box; other site 693444002929 G3 box; other site 693444002930 Switch II region; other site 693444002931 G4 box; other site 693444002932 G5 box; other site 693444002933 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 693444002934 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 693444002935 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 693444002936 ligand-binding site [chemical binding]; other site 693444002937 Protein of unknown function (DUF3561); Region: DUF3561; pfam12084 693444002938 cell division protein FtsB; Reviewed; Region: ftsB; PRK00888 693444002939 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 693444002940 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 693444002941 substrate binding site; other site 693444002942 dimer interface; other site 693444002943 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 693444002944 homotrimer interaction site [polypeptide binding]; other site 693444002945 zinc binding site [ion binding]; other site 693444002946 CDP-binding sites; other site 693444002947 tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984 693444002948 Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575 693444002949 Permutation of conserved domain; other site 693444002950 active site 693444002951 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 693444002952 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 693444002953 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 693444002954 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693444002955 S-adenosylmethionine binding site [chemical binding]; other site 693444002956 lipoprotein NlpD; Provisional; Region: nlpD; PRK10871 693444002957 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 693444002958 Peptidase family M23; Region: Peptidase_M23; pfam01551 693444002959 RNA polymerase sigma factor RpoS; Validated; Region: PRK05657 693444002960 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 693444002961 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 693444002962 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 693444002963 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 693444002964 DNA binding residues [nucleotide binding] 693444002965 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 693444002966 MarR family; Region: MarR; pfam01047 693444002967 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 693444002968 Flavoprotein; Region: Flavoprotein; pfam02441 693444002969 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases [Coenzyme metabolism]; Region: UbiD; COG0043 693444002970 Protein of unknown function (DUF1062); Region: DUF1062; cl01786 693444002971 PrpA and PrpB, metallophosphatase domain; Region: MPP_PrpA_PrpB; cd07424 693444002972 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 693444002973 active site 693444002974 metal binding site [ion binding]; metal-binding site 693444002975 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 693444002976 MutS domain I; Region: MutS_I; pfam01624 693444002977 MutS domain II; Region: MutS_II; pfam05188 693444002978 MutS domain III; Region: MutS_III; pfam05192 693444002979 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 693444002980 Walker A/P-loop; other site 693444002981 ATP binding site [chemical binding]; other site 693444002982 Q-loop/lid; other site 693444002983 ABC transporter signature motif; other site 693444002984 Walker B; other site 693444002985 D-loop; other site 693444002986 H-loop/switch region; other site 693444002987 Nitrous oxide-stimulated promoter; Region: YgbA_NO; pfam11756 693444002988 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 693444002989 FeS/SAM binding site; other site 693444002990 pyruvate formate lyase II activase; Provisional; Region: PRK10076 693444002991 putative formate acetyltransferase 2; Provisional; Region: pflD; PRK09983 693444002992 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 693444002993 dimer interface [polypeptide binding]; other site 693444002994 active site 693444002995 glycine loop; other site 693444002996 formate hydrogenlyase transcriptional activator FhlA; Provisional; Region: PRK15429 693444002997 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 693444002998 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 693444002999 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693444003000 Walker A motif; other site 693444003001 ATP binding site [chemical binding]; other site 693444003002 Walker B motif; other site 693444003003 arginine finger; other site 693444003004 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 693444003005 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 693444003006 dimerization interface [polypeptide binding]; other site 693444003007 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 693444003008 ATP binding site [chemical binding]; other site 693444003009 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 693444003010 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 693444003011 hydrogenase assembly chaperone; Provisional; Region: PRK10409 693444003012 hydrogenase nickel incorporation protein HypB; Provisional; Region: PRK10463 693444003013 Hydrogenase expression/synthesis hypA family; Region: HypA; cl17671 693444003014 hydrogenase nickel incorporation protein; Validated; Region: hypA; PRK03681 693444003015 formate hydrogenlyase regulatory protein HycA; Provisional; Region: PRK10198 693444003016 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 693444003017 formate hydrogenlyase subunit 3; Reviewed; Region: PRK08042 693444003018 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 693444003019 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 693444003020 NADH dehydrogenase; Region: NADHdh; cl00469 693444003021 Ni,Fe-hydrogenase III component G [Energy production and conversion]; Region: HycE; COG3262 693444003022 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 693444003023 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 693444003024 formate hydrogenlyase complex iron-sulfur subunit; Provisional; Region: PRK12387 693444003025 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 693444003026 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 693444003027 formate hydrogenlyase maturation protein HycH; Provisional; Region: PRK15084 693444003028 Endopeptidases belonging to membrane-bound hydrogen evolving hydrogenase group. In hydrogenase 3 from E coli, the maturation of the large subunit (HycE) requires the cleavage of a C-terminal peptide by the endopeptidase HycI, before the final formation...; Region: H2MP_MemB-H2evol; cd06067 693444003029 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 693444003030 nickel binding site [ion binding]; other site 693444003031 PemK-like protein; Region: PemK; pfam02452 693444003032 cryptic 6-phospho-beta-glucosidase; Provisional; Region: PRK09852 693444003033 beta-galactosidase; Region: BGL; TIGR03356 693444003034 PTS system cellobiose/arbutin/salicin-specific transporter subunits IIBC; Provisional; Region: PRK09796 693444003035 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 693444003036 active site turn [active] 693444003037 phosphorylation site [posttranslational modification] 693444003038 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 693444003039 Transcriptional regulators [Transcription]; Region: PurR; COG1609 693444003040 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 693444003041 DNA binding site [nucleotide binding] 693444003042 domain linker motif; other site 693444003043 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 693444003044 dimerization interface (closed form) [polypeptide binding]; other site 693444003045 ligand binding site [chemical binding]; other site 693444003046 formate dehydrogenase-H ferredoxin subunit; Provisional; Region: PRK10330 693444003047 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 693444003048 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 693444003049 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 693444003050 [4Fe-4S] binding site [ion binding]; other site 693444003051 molybdopterin cofactor binding site; other site 693444003052 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790 693444003053 molybdopterin cofactor binding site; other site 693444003054 Acylphosphatase; Region: Acylphosphatase; pfam00708 693444003055 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 693444003056 HypF finger; Region: zf-HYPF; pfam07503 693444003057 HypF finger; Region: zf-HYPF; pfam07503 693444003058 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 693444003059 NADH:flavorubredoxin oxidoreductase; Provisional; Region: PRK04965 693444003060 UAF complex subunit Rrn10; Region: UAF_Rrn10; pfam05234 693444003061 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 693444003062 anaerobic nitric oxide reductase flavorubredoxin; Provisional; Region: PRK05452 693444003063 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 693444003064 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 693444003065 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 693444003066 iron binding site [ion binding]; other site 693444003067 anaerobic nitric oxide reductase transcription regulator; Provisional; Region: PRK05022 693444003068 GAF domain; Region: GAF; pfam01590 693444003069 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693444003070 Walker A motif; other site 693444003071 ATP binding site [chemical binding]; other site 693444003072 Walker B motif; other site 693444003073 arginine finger; other site 693444003074 D-arabinose 5-phosphate isomerase; Provisional; Region: gutQ; PRK11543 693444003075 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 693444003076 putative active site [active] 693444003077 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 693444003078 Transglycosylase SLT domain; Region: SLT_2; pfam13406 693444003079 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 693444003080 N-acetyl-D-glucosamine binding site [chemical binding]; other site 693444003081 catalytic residue [active] 693444003082 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 693444003083 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 693444003084 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 693444003085 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 693444003086 dimer interface [polypeptide binding]; other site 693444003087 putative PBP binding regions; other site 693444003088 ABC-ATPase subunit interface; other site 693444003089 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 693444003090 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 693444003091 metal binding site [ion binding]; metal-binding site 693444003092 Competence-damaged protein; Region: CinA; cl00666 693444003093 recombinase A; Provisional; Region: recA; PRK09354 693444003094 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 693444003095 hexamer interface [polypeptide binding]; other site 693444003096 Walker A motif; other site 693444003097 ATP binding site [chemical binding]; other site 693444003098 Walker B motif; other site 693444003099 recombination regulator RecX; Reviewed; Region: recX; PRK00117 693444003100 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 693444003101 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 693444003102 motif 1; other site 693444003103 active site 693444003104 motif 2; other site 693444003105 motif 3; other site 693444003106 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 693444003107 DHHA1 domain; Region: DHHA1; pfam02272 693444003108 carbon storage regulator; Provisional; Region: PRK01712 693444003109 fructose-1-P/6-phosphogluconate phosphatase; Provisional; Region: PRK10725 693444003110 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 693444003111 active site 693444003112 motif I; other site 693444003113 motif II; other site 693444003114 Predicted membrane protein [Function unknown]; Region: COG1238 693444003115 glutamate--cysteine ligase; Provisional; Region: PRK02107 693444003116 S-ribosylhomocysteinase; Provisional; Region: PRK02260 693444003117 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 693444003118 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693444003119 putative substrate translocation pore; other site 693444003120 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693444003121 multidrug efflux system protein EmrA; Provisional; Region: PRK15136 693444003122 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 693444003123 HlyD family secretion protein; Region: HlyD_3; pfam13437 693444003124 transcriptional repressor MprA; Provisional; Region: PRK10870 693444003125 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 693444003126 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 693444003127 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693444003128 glycine betaine transporter periplasmic subunit; Provisional; Region: proX; PRK11119 693444003129 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 693444003130 glycine betaine transporter membrane protein; Provisional; Region: PRK10952 693444003131 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693444003132 dimer interface [polypeptide binding]; other site 693444003133 conserved gate region; other site 693444003134 putative PBP binding loops; other site 693444003135 ABC-ATPase subunit interface; other site 693444003136 glycine betaine transporter ATP-binding subunit; Provisional; Region: PRK10070 693444003137 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 693444003138 Walker A/P-loop; other site 693444003139 ATP binding site [chemical binding]; other site 693444003140 Q-loop/lid; other site 693444003141 ABC transporter signature motif; other site 693444003142 Walker B; other site 693444003143 D-loop; other site 693444003144 H-loop/switch region; other site 693444003145 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 693444003146 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 693444003147 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 693444003148 dimer interface [polypeptide binding]; other site 693444003149 putative radical transfer pathway; other site 693444003150 diiron center [ion binding]; other site 693444003151 tyrosyl radical; other site 693444003152 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 693444003153 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 693444003154 Class I ribonucleotide reductase; Region: RNR_I; cd01679 693444003155 active site 693444003156 dimer interface [polypeptide binding]; other site 693444003157 catalytic residues [active] 693444003158 effector binding site; other site 693444003159 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 693444003160 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 693444003161 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 693444003162 catalytic residues [active] 693444003163 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 693444003164 Uncharacterized conserved protein [Function unknown]; Region: COG2128 693444003165 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 693444003166 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 693444003167 DNA-binding site [nucleotide binding]; DNA binding site 693444003168 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 693444003169 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693444003170 homodimer interface [polypeptide binding]; other site 693444003171 catalytic residue [active] 693444003172 hypothetical protein; Provisional; Region: PRK10132 693444003173 hypothetical protein; Provisional; Region: PRK10556 693444003174 Protein of unknown function (DUF1144); Region: DUF1144; pfam06610 693444003175 DNA binding protein, nucleoid-associated; Provisional; Region: PRK10328 693444003176 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 693444003177 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 693444003178 active site residue [active] 693444003179 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 693444003180 Fimbrial protein; Region: Fimbrial; cl01416 693444003181 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 693444003182 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 693444003183 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 693444003184 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 693444003185 PapC N-terminal domain; Region: PapC_N; pfam13954 693444003186 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 693444003187 PapC C-terminal domain; Region: PapC_C; pfam13953 693444003188 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 693444003189 LysR family transcriptional regulator; Provisional; Region: PRK14997 693444003190 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693444003191 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 693444003192 putative effector binding pocket; other site 693444003193 dimerization interface [polypeptide binding]; other site 693444003194 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 693444003195 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 693444003196 Winged helix-turn-helix DNA-binding; Region: HTH_35; pfam13693 693444003197 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 693444003198 non-specific DNA binding site [nucleotide binding]; other site 693444003199 salt bridge; other site 693444003200 sequence-specific DNA binding site [nucleotide binding]; other site 693444003201 Protein of unknown function (DUF1294); Region: DUF1294; pfam06961 693444003202 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 693444003203 nudix motif; other site 693444003204 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 693444003205 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 693444003206 Coenzyme A binding pocket [chemical binding]; other site 693444003207 Phage polarity suppression protein (Psu); Region: Psu; pfam07455 693444003208 RT_Bac_retron_I: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_I; cd01646 693444003209 putative active site [active] 693444003210 putative NTP binding site [chemical binding]; other site 693444003211 putative nucleic acid binding site [nucleotide binding]; other site 693444003212 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 693444003213 Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an important role in NAD production by either allowing quinolinic acid (QA) , quinolinate phosphoribosyl transferase (QAPRTase), or nicotinic acid (NA), nicotinate...; Region: PRTase_typeII; cl17275 693444003214 HlyD family secretion protein; Region: HlyD_3; pfam13437 693444003215 type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375 693444003216 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 693444003217 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693444003218 Walker A/P-loop; other site 693444003219 ATP binding site [chemical binding]; other site 693444003220 Q-loop/lid; other site 693444003221 ABC transporter signature motif; other site 693444003222 Walker B; other site 693444003223 D-loop; other site 693444003224 H-loop/switch region; other site 693444003225 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 693444003226 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 693444003227 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 693444003228 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 693444003229 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 693444003230 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 693444003231 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 693444003232 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 693444003233 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 693444003234 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 693444003235 type I secretion C-terminal target domain (VC_A0849 subclass); Region: T1SS_VCA0849; TIGR03661 693444003236 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 693444003237 SmpB-tmRNA interface; other site 693444003238 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 693444003239 putative coenzyme Q binding site [chemical binding]; other site 693444003240 hypothetical protein; Validated; Region: PRK01777 693444003241 outer membrane biogenesis protein BamE; Provisional; Region: PRK11548 693444003242 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 693444003243 recombination and repair protein; Provisional; Region: PRK10869 693444003244 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 693444003245 Walker A/P-loop; other site 693444003246 ATP binding site [chemical binding]; other site 693444003247 Q-loop/lid; other site 693444003248 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 693444003249 ABC transporter signature motif; other site 693444003250 Walker B; other site 693444003251 D-loop; other site 693444003252 H-loop/switch region; other site 693444003253 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03378 693444003254 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 693444003255 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 693444003256 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 693444003257 dimer interface [polypeptide binding]; other site 693444003258 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 693444003259 GAF domain; Region: GAF_2; pfam13185 693444003260 GAF domain; Region: GAF; pfam01590 693444003261 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 693444003262 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 693444003263 hypothetical protein; Provisional; Region: PRK11573 693444003264 Domain of unknown function DUF21; Region: DUF21; pfam01595 693444003265 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 693444003266 Transporter associated domain; Region: CorC_HlyC; smart01091 693444003267 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4137 693444003268 signal recognition particle protein; Provisional; Region: PRK10867 693444003269 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 693444003270 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 693444003271 P loop; other site 693444003272 GTP binding site [chemical binding]; other site 693444003273 Signal peptide binding domain; Region: SRP_SPB; pfam02978 693444003274 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 693444003275 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 693444003276 RimM N-terminal domain; Region: RimM; pfam01782 693444003277 PRC-barrel domain; Region: PRC; pfam05239 693444003278 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 693444003279 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 693444003280 Protein of unknown function (DUF2946); Region: DUF2946; pfam11162 693444003281 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 693444003282 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 693444003283 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 693444003284 putative outer membrane lipoprotein; Provisional; Region: PRK09967 693444003285 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 693444003286 ligand binding site [chemical binding]; other site 693444003287 putative inner membrane diguanylate cyclase; Provisional; Region: PRK09966 693444003288 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693444003289 metal binding site [ion binding]; metal-binding site 693444003290 active site 693444003291 I-site; other site 693444003292 Domain of unknown function (DUF4154); Region: DUF4154; pfam13689 693444003293 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 693444003294 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 693444003295 bifunctional chorismate mutase/prephenate dehydrogenase; Provisional; Region: tyrA; PRK11199 693444003296 Chorismate mutase type II; Region: CM_2; cl00693 693444003297 prephenate dehydrogenase; Validated; Region: PRK08507 693444003298 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 693444003299 bifunctional chorismate mutase/prephenate dehydratase; Provisional; Region: pheA; PRK10622 693444003300 chorismate mutase domain of proteobacterial P-protein, clade 1; Region: CM_P_1; TIGR01797 693444003301 Prephenate dehydratase; Region: PDT; pfam00800 693444003302 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 693444003303 putative L-Phe binding site [chemical binding]; other site 693444003304 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 693444003305 30S subunit binding site; other site 693444003306 outer membrane biogenesis protein BamD; Provisional; Region: PRK10866 693444003307 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 693444003308 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 693444003309 RNA binding surface [nucleotide binding]; other site 693444003310 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 693444003311 active site 693444003312 hypothetical protein; Provisional; Region: PRK10723 693444003313 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 693444003314 protein disaggregation chaperone; Provisional; Region: PRK10865 693444003315 Clp amino terminal domain; Region: Clp_N; pfam02861 693444003316 Clp amino terminal domain; Region: Clp_N; pfam02861 693444003317 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693444003318 Walker A motif; other site 693444003319 ATP binding site [chemical binding]; other site 693444003320 Walker B motif; other site 693444003321 arginine finger; other site 693444003322 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693444003323 Walker A motif; other site 693444003324 ATP binding site [chemical binding]; other site 693444003325 Walker B motif; other site 693444003326 arginine finger; other site 693444003327 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 693444003328 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 693444003329 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693444003330 putative substrate translocation pore; other site 693444003331 lipoprotein; Provisional; Region: PRK10759 693444003332 phosphatidylserine synthase; Provisional; Region: pssA; PRK09428 693444003333 Catalytic domain, repeat 1, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_1; cd09134 693444003334 domain interface [polypeptide binding]; other site 693444003335 putative active site [active] 693444003336 catalytic site [active] 693444003337 Catalytic domain, repeat 2, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_2; cd09136 693444003338 domain interface [polypeptide binding]; other site 693444003339 putative active site [active] 693444003340 catalytic site [active] 693444003341 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 693444003342 CoA binding domain; Region: CoA_binding_2; pfam13380 693444003343 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 693444003344 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 693444003345 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 693444003346 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 693444003347 Uncharacterized conserved protein [Function unknown]; Region: COG3148 693444003348 thioredoxin 2; Provisional; Region: PRK10996 693444003349 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 693444003350 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 693444003351 catalytic residues [active] 693444003352 putative methyltransferase; Provisional; Region: PRK10864 693444003353 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 693444003354 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 693444003355 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 693444003356 ligand binding site [chemical binding]; other site 693444003357 active site 693444003358 UGI interface [polypeptide binding]; other site 693444003359 catalytic site [active] 693444003360 autonomous glycyl radical cofactor GrcA; Provisional; Region: PRK11127 693444003361 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 693444003362 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 693444003363 ATP binding site [chemical binding]; other site 693444003364 Mg++ binding site [ion binding]; other site 693444003365 motif III; other site 693444003366 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 693444003367 nucleotide binding region [chemical binding]; other site 693444003368 ATP-binding site [chemical binding]; other site 693444003369 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 693444003370 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693444003371 S-adenosylmethionine binding site [chemical binding]; other site 693444003372 L-aspartate oxidase; Provisional; Region: PRK09077 693444003373 L-aspartate oxidase; Provisional; Region: PRK06175 693444003374 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 693444003375 RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939 693444003376 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 693444003377 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 693444003378 DNA binding residues [nucleotide binding] 693444003379 anti-RNA polymerase sigma factor SigE; Provisional; Region: PRK10863 693444003380 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 693444003381 Anti sigma-E protein RseA, C-terminal domain; Region: RseA_C; pfam03873 693444003382 Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026 693444003383 anti-sigma E factor; Provisional; Region: rseB; PRK09455 693444003384 Positive regulator of sigma(E), RseC/MucC; Region: RseC_MucC; cl01178 693444003385 GTP-binding protein LepA; Provisional; Region: PRK05433 693444003386 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 693444003387 G1 box; other site 693444003388 putative GEF interaction site [polypeptide binding]; other site 693444003389 GTP/Mg2+ binding site [chemical binding]; other site 693444003390 Switch I region; other site 693444003391 G2 box; other site 693444003392 G3 box; other site 693444003393 Switch II region; other site 693444003394 G4 box; other site 693444003395 G5 box; other site 693444003396 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 693444003397 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 693444003398 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 693444003399 signal peptidase I; Provisional; Region: PRK10861 693444003400 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 693444003401 Catalytic site [active] 693444003402 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 693444003403 ribonuclease III; Reviewed; Region: rnc; PRK00102 693444003404 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 693444003405 dimerization interface [polypeptide binding]; other site 693444003406 active site 693444003407 metal binding site [ion binding]; metal-binding site 693444003408 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 693444003409 dsRNA binding site [nucleotide binding]; other site 693444003410 GTPase Era; Reviewed; Region: era; PRK00089 693444003411 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 693444003412 G1 box; other site 693444003413 GTP/Mg2+ binding site [chemical binding]; other site 693444003414 Switch I region; other site 693444003415 G2 box; other site 693444003416 Switch II region; other site 693444003417 G3 box; other site 693444003418 G4 box; other site 693444003419 G5 box; other site 693444003420 KH domain; Region: KH_2; pfam07650 693444003421 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 693444003422 Recombination protein O N terminal; Region: RecO_N; pfam11967 693444003423 Recombination protein O C terminal; Region: RecO_C; pfam02565 693444003424 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 693444003425 active site 693444003426 hydrophilic channel; other site 693444003427 dimerization interface [polypeptide binding]; other site 693444003428 catalytic residues [active] 693444003429 active site lid [active] 693444003430 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 693444003431 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 693444003432 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 693444003433 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11557 693444003434 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 693444003435 putative active site [active] 693444003436 hypothetical protein; Provisional; Region: PRK11590 693444003437 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 693444003438 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 693444003439 nucleoside/Zn binding site; other site 693444003440 dimer interface [polypeptide binding]; other site 693444003441 catalytic motif [active] 693444003442 membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859 693444003443 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 693444003444 substrate binding pocket [chemical binding]; other site 693444003445 membrane-bound complex binding site; other site 693444003446 hinge residues; other site 693444003447 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 693444003448 N-acetyl-D-glucosamine binding site [chemical binding]; other site 693444003449 catalytic residue [active] 693444003450 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 693444003451 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 693444003452 dimerization interface [polypeptide binding]; other site 693444003453 ATP binding site [chemical binding]; other site 693444003454 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 693444003455 dimerization interface [polypeptide binding]; other site 693444003456 ATP binding site [chemical binding]; other site 693444003457 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 693444003458 putative active site [active] 693444003459 catalytic triad [active] 693444003460 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 693444003461 HAMP domain; Region: HAMP; pfam00672 693444003462 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 693444003463 dimer interface [polypeptide binding]; other site 693444003464 phosphorylation site [posttranslational modification] 693444003465 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693444003466 ATP binding site [chemical binding]; other site 693444003467 Mg2+ binding site [ion binding]; other site 693444003468 G-X-G motif; other site 693444003469 hypothetical protein; Provisional; Region: PRK10722 693444003470 response regulator GlrR; Provisional; Region: PRK15115 693444003471 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693444003472 active site 693444003473 phosphorylation site [posttranslational modification] 693444003474 intermolecular recognition site; other site 693444003475 dimerization interface [polypeptide binding]; other site 693444003476 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693444003477 Walker A motif; other site 693444003478 ATP binding site [chemical binding]; other site 693444003479 Walker B motif; other site 693444003480 arginine finger; other site 693444003481 nitrogen regulatory protein P-II 1; Provisional; Region: PRK10858 693444003482 Nitrogen regulatory protein P-II; Region: P-II; smart00938 693444003483 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 693444003484 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 693444003485 heme-binding site [chemical binding]; other site 693444003486 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 693444003487 FAD binding pocket [chemical binding]; other site 693444003488 FAD binding motif [chemical binding]; other site 693444003489 phosphate binding motif [ion binding]; other site 693444003490 beta-alpha-beta structure motif; other site 693444003491 NAD binding pocket [chemical binding]; other site 693444003492 Heme binding pocket [chemical binding]; other site 693444003493 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 693444003494 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 693444003495 dimer interface [polypeptide binding]; other site 693444003496 active site 693444003497 glycine-pyridoxal phosphate binding site [chemical binding]; other site 693444003498 folate binding site [chemical binding]; other site 693444003499 Predicted membrane protein [Function unknown]; Region: COG2259 693444003500 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 693444003501 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 693444003502 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 693444003503 2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase; Provisional; Region: PRK06200 693444003504 cis-biphenyl-2,3-dihydrodiol-2,3-dehydrogenase (BphB)-like, classical (c) SDRs; Region: BphB-like_SDR_c; cd05348 693444003505 NAD binding site [chemical binding]; other site 693444003506 active site 693444003507 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 693444003508 [2Fe-2S] cluster binding site [ion binding]; other site 693444003509 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 693444003510 inter-subunit interface; other site 693444003511 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 693444003512 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 693444003513 iron-sulfur cluster [ion binding]; other site 693444003514 [2Fe-2S] cluster binding site [ion binding]; other site 693444003515 C-terminal catalytic domain of the oxygenase alpha subunit of naphthalene 1,2-dioxygenase (NDO) and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_NDO-like; cd08881 693444003516 beta subunit interface [polypeptide binding]; other site 693444003517 alpha subunit interface [polypeptide binding]; other site 693444003518 active site 693444003519 substrate binding site [chemical binding]; other site 693444003520 Fe binding site [ion binding]; other site 693444003521 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 693444003522 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693444003523 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 693444003524 dimerization interface [polypeptide binding]; other site 693444003525 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 693444003526 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693444003527 putative substrate translocation pore; other site 693444003528 stationary phase inducible protein CsiE; Provisional; Region: PRK11564 693444003529 PRD domain; Region: PRD; pfam00874 693444003530 Protein of unknown function (DUF1007); Region: DUF1007; pfam06226 693444003531 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG2215 693444003532 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 693444003533 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 693444003534 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 693444003535 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 693444003536 active site 693444003537 dimerization interface [polypeptide binding]; other site 693444003538 tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ; Provisional; Region: PRK15114 693444003539 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 693444003540 yybP-ykoY leader; D782_1140; IMG reference gene:2507515836 693444003541 DNA-binding transcriptional regulator IscR; Provisional; Region: PRK10857 693444003542 Rrf2 family protein; Region: rrf2_super; TIGR00738 693444003543 cysteine desulfurase; Provisional; Region: PRK14012 693444003544 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 693444003545 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 693444003546 catalytic residue [active] 693444003547 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 693444003548 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 693444003549 trimerization site [polypeptide binding]; other site 693444003550 active site 693444003551 iron-sulfur cluster assembly protein; Provisional; Region: iscA; PRK09502 693444003552 co-chaperone HscB; Provisional; Region: hscB; PRK05014 693444003553 DnaJ domain; Region: DnaJ; pfam00226 693444003554 HSP70 interaction site [polypeptide binding]; other site 693444003555 HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743 693444003556 chaperone protein HscA; Provisional; Region: hscA; PRK05183 693444003557 Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236 693444003558 nucleotide binding site [chemical binding]; other site 693444003559 putative NEF/HSP70 interaction site [polypeptide binding]; other site 693444003560 SBD interface [polypeptide binding]; other site 693444003561 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 693444003562 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 693444003563 catalytic loop [active] 693444003564 iron binding site [ion binding]; other site 693444003565 hypothetical protein; Provisional; Region: PRK10721 693444003566 aminopeptidase B; Provisional; Region: PRK05015 693444003567 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 693444003568 interface (dimer of trimers) [polypeptide binding]; other site 693444003569 Substrate-binding/catalytic site; other site 693444003570 Zn-binding sites [ion binding]; other site 693444003571 enhanced serine sensitivity protein SseB; Provisional; Region: PRK11611 693444003572 3-mercaptopyruvate sulfurtransferase; Provisional; Region: sseA; PRK11493 693444003573 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 693444003574 active site residue [active] 693444003575 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 693444003576 active site residue [active] 693444003577 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 693444003578 MG2 domain; Region: A2M_N; pfam01835 693444003579 Alpha-2-macroglobulin family; Region: A2M; pfam00207 693444003580 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 693444003581 surface patch; other site 693444003582 thioester region; other site 693444003583 specificity defining residues; other site 693444003584 penicillin-binding protein 1C; Provisional; Region: PRK11240 693444003585 Transglycosylase; Region: Transgly; pfam00912 693444003586 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 693444003587 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 693444003588 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 693444003589 active site 693444003590 multimer interface [polypeptide binding]; other site 693444003591 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 693444003592 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 693444003593 FeS/SAM binding site; other site 693444003594 cytoskeletal protein RodZ; Provisional; Region: PRK10856 693444003595 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 693444003596 non-specific DNA binding site [nucleotide binding]; other site 693444003597 salt bridge; other site 693444003598 sequence-specific DNA binding site [nucleotide binding]; other site 693444003599 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 693444003600 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 693444003601 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 693444003602 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 693444003603 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 693444003604 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 693444003605 dimer interface [polypeptide binding]; other site 693444003606 motif 1; other site 693444003607 active site 693444003608 motif 2; other site 693444003609 motif 3; other site 693444003610 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 693444003611 anticodon binding site; other site 693444003612 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 693444003613 Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976 693444003614 outer membrane biogenesis protein BamB; Provisional; Region: PRK11138 693444003615 Beta-barrel assembly machinery (Bam) complex component B and related proteins; Region: BamB_YfgL; cd10276 693444003616 Trp docking motif [polypeptide binding]; other site 693444003617 GTP-binding protein Der; Reviewed; Region: PRK00093 693444003618 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 693444003619 G1 box; other site 693444003620 GTP/Mg2+ binding site [chemical binding]; other site 693444003621 Switch I region; other site 693444003622 G2 box; other site 693444003623 Switch II region; other site 693444003624 G3 box; other site 693444003625 G4 box; other site 693444003626 G5 box; other site 693444003627 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 693444003628 G1 box; other site 693444003629 GTP/Mg2+ binding site [chemical binding]; other site 693444003630 Switch I region; other site 693444003631 G2 box; other site 693444003632 G3 box; other site 693444003633 Switch II region; other site 693444003634 G4 box; other site 693444003635 G5 box; other site 693444003636 Protein of unknown function (DUF1407); Region: DUF1407; pfam07191 693444003637 exodeoxyribonuclease VII, large subunit; Region: xseA; TIGR00237 693444003638 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 693444003639 generic binding surface II; other site 693444003640 generic binding surface I; other site 693444003641 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 693444003642 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 693444003643 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 693444003644 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 693444003645 active site 693444003646 GMP synthase; Reviewed; Region: guaA; PRK00074 693444003647 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 693444003648 AMP/PPi binding site [chemical binding]; other site 693444003649 candidate oxyanion hole; other site 693444003650 catalytic triad [active] 693444003651 potential glutamine specificity residues [chemical binding]; other site 693444003652 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 693444003653 ATP Binding subdomain [chemical binding]; other site 693444003654 Ligand Binding sites [chemical binding]; other site 693444003655 Dimerization subdomain; other site 693444003656 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 693444003657 Sel1-like repeats; Region: SEL1; smart00671 693444003658 Sel1-like repeats; Region: SEL1; smart00671 693444003659 Sel1-like repeats; Region: SEL1; smart00671 693444003660 Sel1-like repeats; Region: SEL1; smart00671 693444003661 Sel1-like repeats; Region: SEL1; smart00671 693444003662 Sel1-like repeats; Region: SEL1; smart00671 693444003663 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 693444003664 active site 693444003665 catalytic site [active] 693444003666 substrate binding site [chemical binding]; other site 693444003667 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 693444003668 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 693444003669 ATP binding site [chemical binding]; other site 693444003670 putative Mg++ binding site [ion binding]; other site 693444003671 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 693444003672 nucleotide binding region [chemical binding]; other site 693444003673 ATP-binding site [chemical binding]; other site 693444003674 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 693444003675 Part of AAA domain; Region: AAA_19; pfam13245 693444003676 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 693444003677 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 693444003678 Family description; Region: UvrD_C_2; pfam13538 693444003679 Protein of unknown function (DUF2633); Region: DUF2633; pfam11119 693444003680 MASE1; Region: MASE1; pfam05231 693444003681 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 693444003682 diguanylate cyclase; Region: GGDEF; smart00267 693444003683 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 693444003684 exopolyphosphatase; Provisional; Region: PRK10854 693444003685 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 693444003686 nucleotide binding site [chemical binding]; other site 693444003687 Polyphosphate kinase [Inorganic ion transport and metabolism]; Region: Ppk; COG0855 693444003688 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 693444003689 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 693444003690 Catalytic C-terminal domain, first repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C1_like; cd09164 693444003691 domain interface [polypeptide binding]; other site 693444003692 active site 693444003693 catalytic site [active] 693444003694 Catalytic C-terminal domain, second repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C2_like; cd09167 693444003695 domain interface [polypeptide binding]; other site 693444003696 active site 693444003697 catalytic site [active] 693444003698 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 693444003699 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 693444003700 active site 693444003701 substrate binding site [chemical binding]; other site 693444003702 cosubstrate binding site; other site 693444003703 catalytic site [active] 693444003704 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 693444003705 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 693444003706 dimerization interface [polypeptide binding]; other site 693444003707 putative ATP binding site [chemical binding]; other site 693444003708 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 693444003709 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 693444003710 nucleotide binding site [chemical binding]; other site 693444003711 6-phospho-beta-glucosidase; Reviewed; Region: celA; PRK09589 693444003712 beta-galactosidase; Region: BGL; TIGR03356 693444003713 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 693444003714 active site 693444003715 uracil transporter; Provisional; Region: PRK10720 693444003716 DNA replication initiation factor; Provisional; Region: PRK08084 693444003717 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 693444003718 hypothetical protein; Provisional; Region: PRK09956 693444003719 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 693444003720 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 693444003721 ArsC family; Region: ArsC; pfam03960 693444003722 catalytic residues [active] 693444003723 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 693444003724 Peptidase family M48; Region: Peptidase_M48; cl12018 693444003725 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 693444003726 Domain of unknown function DUF20; Region: UPF0118; pfam01594 693444003727 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 693444003728 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 693444003729 catalytic triad [active] 693444003730 glycine cleavage system transcriptional repressor; Provisional; Region: gcvR; PRK11589 693444003731 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_1; cd04893 693444003732 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 693444003733 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 693444003734 dihydrodipicolinate synthase; Region: dapA; TIGR00674 693444003735 dimer interface [polypeptide binding]; other site 693444003736 active site 693444003737 catalytic residue [active] 693444003738 lipoprotein; Provisional; Region: PRK11679 693444003739 NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804 693444003740 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 693444003741 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 693444003742 ATP binding site [chemical binding]; other site 693444003743 active site 693444003744 substrate binding site [chemical binding]; other site 693444003745 Predicted metalloprotease [General function prediction only]; Region: COG2321 693444003746 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 693444003747 Predicted P-loop ATPase fused to an acetyltransferase [General function prediction only]; Region: COG1444 693444003748 Domain of unknown function (DUF1726); Region: DUF1726; pfam08351 693444003749 Helicase; Region: Helicase_RecD; pfam05127 693444003750 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 693444003751 Coenzyme A binding pocket [chemical binding]; other site 693444003752 putative hydrolase; Provisional; Region: PRK11460 693444003753 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 693444003754 hypothetical protein; Provisional; Region: PRK13664 693444003755 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 693444003756 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 693444003757 metal binding site [ion binding]; metal-binding site 693444003758 dimer interface [polypeptide binding]; other site 693444003759 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 693444003760 ArsC family; Region: ArsC; pfam03960 693444003761 putative catalytic residues [active] 693444003762 aminoglycoside/multidrug efflux system; Provisional; Region: PRK10555 693444003763 Protein export membrane protein; Region: SecD_SecF; cl14618 693444003764 Protein export membrane protein; Region: SecD_SecF; cl14618 693444003765 putative oxidoreductase Fe-S binding subunit; Reviewed; Region: PRK12769 693444003766 4Fe-4S binding domain; Region: Fer4; pfam00037 693444003767 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 693444003768 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 693444003769 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 693444003770 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 693444003771 dimer interface [polypeptide binding]; other site 693444003772 ADP-ribose binding site [chemical binding]; other site 693444003773 active site 693444003774 nudix motif; other site 693444003775 metal binding site [ion binding]; metal-binding site 693444003776 Protein of unknown function (DUF1176); Region: DUF1176; pfam06674 693444003777 transketolase; Reviewed; Region: PRK12753 693444003778 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 693444003779 TPP-binding site [chemical binding]; other site 693444003780 dimer interface [polypeptide binding]; other site 693444003781 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 693444003782 PYR/PP interface [polypeptide binding]; other site 693444003783 dimer interface [polypeptide binding]; other site 693444003784 TPP binding site [chemical binding]; other site 693444003785 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 693444003786 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 693444003787 Malic enzyme, N-terminal domain; Region: malic; pfam00390 693444003788 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 693444003789 putative NAD(P) binding site [chemical binding]; other site 693444003790 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 693444003791 1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046 693444003792 putative hexamer interface [polypeptide binding]; other site 693444003793 putative hexagonal pore; other site 693444003794 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 693444003795 G1 box; other site 693444003796 GTP/Mg2+ binding site [chemical binding]; other site 693444003797 G2 box; other site 693444003798 Switch I region; other site 693444003799 G3 box; other site 693444003800 Switch II region; other site 693444003801 G4 box; other site 693444003802 G5 box; other site 693444003803 ethanolamine utilization protein EutQ; Provisional; Region: PRK15457 693444003804 Ethanolamine utilization protein [Amino acid transport and metabolism]; Region: EutQ; COG4766 693444003805 ethanolamine utilization cobalamin adenosyltransferase; Provisional; Region: PRK15020 693444003806 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 693444003807 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 693444003808 1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059 693444003809 Hexamer interface [polypeptide binding]; other site 693444003810 Putative hexagonal pore residue; other site 693444003811 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 693444003812 Hexamer/Pentamer interface [polypeptide binding]; other site 693444003813 central pore; other site 693444003814 Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121 693444003815 putative catalytic cysteine [active] 693444003816 Ethanolamine utilization protein, possible chaperonin [Amino acid transport and metabolism]; Region: EutJ; COG4820 693444003817 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 693444003818 nucleotide binding site [chemical binding]; other site 693444003819 ethanol dehydrogenase EutG; Provisional; Region: PRK15454 693444003820 iron-containing alcohol dehydrogenases (Fe-ADH)-like; Region: Fe-ADH; cd08551 693444003821 active site 693444003822 metal binding site [ion binding]; metal-binding site 693444003823 Ethanolamine utilization protein [Amino acid transport and metabolism]; Region: EutH; COG3192 693444003824 reactivating factor for ethanolamine ammonia lyase; Provisional; Region: eutA; PRK10719 693444003825 Ethanolamine ammonia-lyase, large subunit [Amino acid transport and metabolism]; Region: EutB; COG4303 693444003826 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 693444003827 Ethanolamine ammonia-lyase, small subunit [Amino acid transport and metabolism]; Region: EutC; COG4302 693444003828 ethanolamine utilization protein EutL; Provisional; Region: PRK15405 693444003829 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_EutL_repeat1; cd07049 693444003830 putative hexamer interface [polypeptide binding]; other site 693444003831 putative hexagonal pore; other site 693444003832 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_EutL_repeat2; cd07050 693444003833 putative hexamer interface [polypeptide binding]; other site 693444003834 putative hexagonal pore; other site 693444003835 carboxysome structural protein EutK; Provisional; Region: PRK15466 693444003836 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 693444003837 Hexamer interface [polypeptide binding]; other site 693444003838 Hexagonal pore residue; other site 693444003839 transcriptional regulator EutR; Provisional; Region: PRK10130 693444003840 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 693444003841 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 693444003842 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 693444003843 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 693444003844 N-acetylmuramoyl-l-alanine amidase I; Provisional; Region: PRK10319 693444003845 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 693444003846 active site 693444003847 metal binding site [ion binding]; metal-binding site 693444003848 putative acetyltransferase; Provisional; Region: PRK03624 693444003849 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 693444003850 Coenzyme A binding pocket [chemical binding]; other site 693444003851 Protein of unknown function (DUF2919); Region: DUF2919; pfam11143 693444003852 RpoE-regulated lipoprotein; Provisional; Region: PRK10718 693444003853 Protein of unknown function (DUF1131); Region: DUF1131; pfam06572 693444003854 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 693444003855 short chain dehydrogenase; Provisional; Region: PRK08226 693444003856 human DHRS6-like, classical (c) SDRs; Region: DHRS6_like_SDR_c; cd05368 693444003857 NAD binding site [chemical binding]; other site 693444003858 homotetramer interface [polypeptide binding]; other site 693444003859 homodimer interface [polypeptide binding]; other site 693444003860 active site 693444003861 thiosulfate transporter subunit; Provisional; Region: PRK10852 693444003862 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 693444003863 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 693444003864 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693444003865 dimer interface [polypeptide binding]; other site 693444003866 conserved gate region; other site 693444003867 putative PBP binding loops; other site 693444003868 ABC-ATPase subunit interface; other site 693444003869 sulfate transport protein; Provisional; Region: cysT; CHL00187 693444003870 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693444003871 dimer interface [polypeptide binding]; other site 693444003872 conserved gate region; other site 693444003873 putative PBP binding loops; other site 693444003874 ABC-ATPase subunit interface; other site 693444003875 sulfate/thiosulfate transporter subunit; Provisional; Region: PRK10851 693444003876 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 693444003877 Walker A/P-loop; other site 693444003878 ATP binding site [chemical binding]; other site 693444003879 Q-loop/lid; other site 693444003880 ABC transporter signature motif; other site 693444003881 Walker B; other site 693444003882 D-loop; other site 693444003883 H-loop/switch region; other site 693444003884 TOBE-like domain; Region: TOBE_3; pfam12857 693444003885 cysteine synthase B; Region: cysM; TIGR01138 693444003886 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 693444003887 dimer interface [polypeptide binding]; other site 693444003888 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693444003889 catalytic residue [active] 693444003890 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 693444003891 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 693444003892 dimer interface [polypeptide binding]; other site 693444003893 pyridoxamine kinase; Validated; Region: PRK05756 693444003894 pyridoxal binding site [chemical binding]; other site 693444003895 ATP binding site [chemical binding]; other site 693444003896 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 693444003897 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 693444003898 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 693444003899 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 693444003900 HPr interaction site; other site 693444003901 glycerol kinase (GK) interaction site [polypeptide binding]; other site 693444003902 active site 693444003903 phosphorylation site [posttranslational modification] 693444003904 phosphoenolpyruvate-protein phosphotransferase; Provisional; Region: PRK11177 693444003905 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 693444003906 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 693444003907 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 693444003908 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 693444003909 dimerization domain swap beta strand [polypeptide binding]; other site 693444003910 regulatory protein interface [polypeptide binding]; other site 693444003911 active site 693444003912 regulatory phosphorylation site [posttranslational modification]; other site 693444003913 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 693444003914 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 693444003915 dimer interface [polypeptide binding]; other site 693444003916 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693444003917 catalytic residue [active] 693444003918 putative sulfate transport protein CysZ; Validated; Region: PRK04949 693444003919 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cl12038 693444003920 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cd00231 693444003921 FtsZ protein binding site [polypeptide binding]; other site 693444003922 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 693444003923 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 693444003924 nucleotide binding pocket [chemical binding]; other site 693444003925 K-X-D-G motif; other site 693444003926 catalytic site [active] 693444003927 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 693444003928 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 693444003929 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 693444003930 Dimer interface [polypeptide binding]; other site 693444003931 BRCT sequence motif; other site 693444003932 Protein of unknown function (DUF3820); Region: DUF3820; pfam12843 693444003933 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 693444003934 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 693444003935 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693444003936 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693444003937 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 693444003938 putative dimerization interface [polypeptide binding]; other site 693444003939 hypothetical protein; Provisional; Region: PRK11528 693444003940 purine nucleoside phosphorylase; Provisional; Region: PRK08202 693444003941 nucleoside transporter; Region: 2A0110; TIGR00889 693444003942 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693444003943 putative substrate translocation pore; other site 693444003944 XapX domain; Region: XapX; TIGR03510 693444003945 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 693444003946 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693444003947 The C-terminal substrate binding domain of LysR-type transcriptional regulator XapR involved in xanthosine catabolism, contains the type 2 periplasmic binding fold; Region: PBP2_XapR; cd08449 693444003948 putative dimerization interface [polypeptide binding]; other site 693444003949 putative substrate binding pocket [chemical binding]; other site 693444003950 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 693444003951 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 693444003952 active site 693444003953 HIGH motif; other site 693444003954 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 693444003955 active site 693444003956 KMSKS motif; other site 693444003957 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 693444003958 salt bridge; other site 693444003959 non-specific DNA binding site [nucleotide binding]; other site 693444003960 Putative transcription regulator (DUF1323); Region: DUF1323; pfam07037 693444003961 sequence-specific DNA binding site [nucleotide binding]; other site 693444003962 Putative transcription regulator (DUF1323); Region: DUF1323; pfam07037 693444003963 MASE1; Region: MASE1; pfam05231 693444003964 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 693444003965 diguanylate cyclase; Region: GGDEF; smart00267 693444003966 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 693444003967 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 693444003968 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 693444003969 Nucleoside recognition; Region: Gate; pfam07670 693444003970 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 693444003971 manganese transport protein MntH; Reviewed; Region: PRK00701 693444003972 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 693444003973 Protein of unknown function (DUF2502); Region: DUF2502; pfam10697 693444003974 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 693444003975 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 693444003976 active site 693444003977 catalytic tetrad [active] 693444003978 indolepyruvate decarboxylase, Erwinia family; Region: indolpyr_decarb; TIGR03393 693444003979 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 693444003980 dimer interface [polypeptide binding]; other site 693444003981 PYR/PP interface [polypeptide binding]; other site 693444003982 TPP binding site [chemical binding]; other site 693444003983 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 693444003984 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 693444003985 TPP-binding site [chemical binding]; other site 693444003986 dimer interface [polypeptide binding]; other site 693444003987 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 693444003988 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 693444003989 Cl- selectivity filter; other site 693444003990 Cl- binding residues [ion binding]; other site 693444003991 pore gating glutamate residue; other site 693444003992 dimer interface [polypeptide binding]; other site 693444003993 glucokinase; Provisional; Region: glk; PRK00292 693444003994 glucokinase, proteobacterial type; Region: glk; TIGR00749 693444003995 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 693444003996 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 693444003997 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 693444003998 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693444003999 active site 693444004000 phosphorylation site [posttranslational modification] 693444004001 intermolecular recognition site; other site 693444004002 dimerization interface [polypeptide binding]; other site 693444004003 LytTr DNA-binding domain; Region: LytTR; pfam04397 693444004004 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 693444004005 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 693444004006 GAF domain; Region: GAF; pfam01590 693444004007 Histidine kinase; Region: His_kinase; pfam06580 693444004008 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693444004009 ATP binding site [chemical binding]; other site 693444004010 Mg2+ binding site [ion binding]; other site 693444004011 G-X-G motif; other site 693444004012 aminotransferase; Validated; Region: PRK08175 693444004013 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 693444004014 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693444004015 homodimer interface [polypeptide binding]; other site 693444004016 catalytic residue [active] 693444004017 isoaspartyl dipeptidase; Provisional; Region: PRK10657 693444004018 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 693444004019 active site 693444004020 hypothetical protein; Provisional; Region: PRK10519 693444004021 Nucleoside recognition; Region: Gate; pfam07670 693444004022 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 693444004023 NAD(P) binding site [chemical binding]; other site 693444004024 short chain dehydrogenase; Provisional; Region: PRK06523 693444004025 active site 693444004026 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 693444004027 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 693444004028 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 693444004029 Protein of unknown function (DUF3500); Region: DUF3500; pfam12006 693444004030 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 693444004031 homotrimer interaction site [polypeptide binding]; other site 693444004032 putative active site [active] 693444004033 Predicted transcriptional regulators [Transcription]; Region: COG1695 693444004034 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 693444004035 Uncharacterized protein conserved in bacteria (DUF2218); Region: DUF2218; pfam09981 693444004036 Amidohydrolase; Region: Amidohydro_2; pfam04909 693444004037 hypothetical protein; Provisional; Region: PRK07538 693444004038 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 693444004039 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693444004040 putative substrate translocation pore; other site 693444004041 D-galactonate transporter; Region: 2A0114; TIGR00893 693444004042 N-terminal domain of 3,4-dihydroxyphenylacetate 2,3-dioxygenase (HPCD); belongs to the type I class II family of extradiol dioxygenases; Region: HPCD_N_class_II; cd07266 693444004043 3,4-dihydroxyphenylacetate 2,3-dioxygenase; Region: HpaD; TIGR02295 693444004044 tetramer interface [polypeptide binding]; other site 693444004045 C-terminal domain of 3,4-dihydroxyphenylacetate 2,3-dioxygenase (HPCD), which catalyses the second step in the degradation of 4-hydroxyphenylacetate to succinate and pyruvate; belongs to the type I class II family of extradiol dioxygenases; Region: HPCD_C_class_II; cd07256 693444004046 tetramer interface [polypeptide binding]; other site 693444004047 active site 693444004048 metal binding site [ion binding]; metal-binding site 693444004049 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 693444004050 classical (c) SDRs; Region: SDR_c; cd05233 693444004051 NAD(P) binding site [chemical binding]; other site 693444004052 active site 693444004053 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 693444004054 osmolarity response regulator; Provisional; Region: ompR; PRK09468 693444004055 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693444004056 active site 693444004057 phosphorylation site [posttranslational modification] 693444004058 intermolecular recognition site; other site 693444004059 dimerization interface [polypeptide binding]; other site 693444004060 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 693444004061 DNA binding site [nucleotide binding] 693444004062 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 693444004063 dimer interface [polypeptide binding]; other site 693444004064 phosphorylation site [posttranslational modification] 693444004065 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693444004066 ATP binding site [chemical binding]; other site 693444004067 Mg2+ binding site [ion binding]; other site 693444004068 G-X-G motif; other site 693444004069 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 693444004070 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 693444004071 TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012 693444004072 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 693444004073 catalytic residues [active] 693444004074 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 693444004075 Coenzyme A binding pocket [chemical binding]; other site 693444004076 Uncharacterized conserved protein [Function unknown]; Region: COG3592 693444004077 Polymyxin resistance protein PmrD; Region: PmrD; cl12732 693444004078 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 693444004079 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 693444004080 inhibitor-cofactor binding pocket; inhibition site 693444004081 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693444004082 catalytic residue [active] 693444004083 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 693444004084 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 693444004085 Ligand binding site; other site 693444004086 Putative Catalytic site; other site 693444004087 DXD motif; other site 693444004088 bifunctional UDP-glucuronic acid decarboxylase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase; Validated; Region: PRK08125 693444004089 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 693444004090 active site 693444004091 substrate binding site [chemical binding]; other site 693444004092 cosubstrate binding site; other site 693444004093 catalytic site [active] 693444004094 C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702 693444004095 active site 693444004096 hexamer interface [polypeptide binding]; other site 693444004097 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 693444004098 NAD binding site [chemical binding]; other site 693444004099 substrate binding site [chemical binding]; other site 693444004100 active site 693444004101 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD; Provisional; Region: PRK15394 693444004102 Catalytic domain of Escherichia coli 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD and other bacterial homologs; Region: CE4_ArnD; cd10939 693444004103 putative active site [active] 693444004104 putative catalytic site [active] 693444004105 putative Zn binding site [ion binding]; other site 693444004106 4-amino-4-deoxy-L-arabinose transferase; Provisional; Region: arnT; PRK13279 693444004107 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 693444004108 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051 693444004109 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971 693444004110 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 693444004111 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693444004112 putative substrate translocation pore; other site 693444004113 Transcriptional regulators [Transcription]; Region: MarR; COG1846 693444004114 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 693444004115 Amidase; Region: Amidase; cl11426 693444004116 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 693444004117 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 693444004118 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 693444004119 active site 693444004120 SnoaL-like domain; Region: SnoaL_4; pfam13577 693444004121 benzoate 1,2-dioxygenase, large subunit; Region: benzo_1_2_benA; TIGR03229 693444004122 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 693444004123 [2Fe-2S] cluster binding site [ion binding]; other site 693444004124 C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879 693444004125 putative alpha subunit interface [polypeptide binding]; other site 693444004126 putative active site [active] 693444004127 putative substrate binding site [chemical binding]; other site 693444004128 Fe binding site [ion binding]; other site 693444004129 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 693444004130 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 693444004131 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 693444004132 NAD(P) binding site [chemical binding]; other site 693444004133 active site 693444004134 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 693444004135 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 693444004136 FMN-binding pocket [chemical binding]; other site 693444004137 flavin binding motif; other site 693444004138 phosphate binding motif [ion binding]; other site 693444004139 beta-alpha-beta structure motif; other site 693444004140 NAD binding pocket [chemical binding]; other site 693444004141 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 693444004142 catalytic loop [active] 693444004143 iron binding site [ion binding]; other site 693444004144 Flavin Reductases; Region: FlaRed; cl00801 693444004145 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693444004146 metabolite-proton symporter; Region: 2A0106; TIGR00883 693444004147 putative substrate translocation pore; other site 693444004148 catechol 1,2-dioxygenase, proteobacterial; Region: catechol_proteo; TIGR02439 693444004149 Catechol 1,2 dioxygenase (1,2-CTD) catalyzes an intradiol cleavage reaction of catechol to form cis,cis-muconate. 1,2-CTDs is homodimers with one catalytic non-heme ferric ion per monomer. They belong to the aromatic dioxygenase family, a family of...; Region: 1,2-CTD; cd03460 693444004150 dimer interface [polypeptide binding]; other site 693444004151 active site 693444004152 DoxX; Region: DoxX; pfam07681 693444004153 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 693444004154 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 693444004155 Trp docking motif [polypeptide binding]; other site 693444004156 putative active site [active] 693444004157 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 693444004158 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693444004159 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693444004160 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 693444004161 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 693444004162 Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms]; Region: COG4192 693444004163 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693444004164 ATP binding site [chemical binding]; other site 693444004165 Mg2+ binding site [ion binding]; other site 693444004166 G-X-G motif; other site 693444004167 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 693444004168 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693444004169 active site 693444004170 phosphorylation site [posttranslational modification] 693444004171 intermolecular recognition site; other site 693444004172 dimerization interface [polypeptide binding]; other site 693444004173 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 693444004174 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 693444004175 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 693444004176 ABC transporter outer membrane lipoprotein; Provisional; Region: PRK15091 693444004177 long-chain fatty acid outer membrane transporter; Provisional; Region: PRK10716 693444004178 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3691 693444004179 3-ketoacyl-CoA thiolase; Reviewed; Region: fadI; PRK08963 693444004180 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 693444004181 dimer interface [polypeptide binding]; other site 693444004182 active site 693444004183 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 693444004184 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 693444004185 substrate binding site [chemical binding]; other site 693444004186 oxyanion hole (OAH) forming residues; other site 693444004187 trimer interface [polypeptide binding]; other site 693444004188 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 693444004189 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 693444004190 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 693444004191 catalytic core [active] 693444004192 hypothetical protein; Provisional; Region: PRK04946 693444004193 Smr domain; Region: Smr; pfam01713 693444004194 HemK family putative methylases; Region: hemK_fam; TIGR00536 693444004195 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693444004196 S-adenosylmethionine binding site [chemical binding]; other site 693444004197 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 693444004198 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 693444004199 Tetramer interface [polypeptide binding]; other site 693444004200 active site 693444004201 FMN-binding site [chemical binding]; other site 693444004202 penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429 693444004203 hypothetical protein; Provisional; Region: PRK10621 693444004204 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 693444004205 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3101 693444004206 YfcL protein; Region: YfcL; pfam08891 693444004207 Homeodomain-like domain; Region: HTH_23; cl17451 693444004208 Winged helix-turn helix; Region: HTH_29; pfam13551 693444004209 Homeodomain-like domain; Region: HTH_32; pfam13565 693444004210 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 693444004211 Integrase core domain; Region: rve; pfam00665 693444004212 Integrase core domain; Region: rve_3; pfam13683 693444004213 Uncharacterized conserved protein [Function unknown]; Region: COG4121 693444004214 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 693444004215 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 693444004216 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 693444004217 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 693444004218 dimer interface [polypeptide binding]; other site 693444004219 active site 693444004220 CAAX protease self-immunity; Region: Abi; pfam02517 693444004221 putative transporter; Provisional; Region: PRK12382 693444004222 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693444004223 putative substrate translocation pore; other site 693444004224 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 693444004225 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 693444004226 DNA-binding site [nucleotide binding]; DNA binding site 693444004227 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 693444004228 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 693444004229 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 693444004230 flagella biosynthesis regulator; Provisional; Region: flk; PRK10715 693444004231 erythronate-4-phosphate dehydrogenase PdxB; Provisional; Region: PRK15438 693444004232 D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158 693444004233 ligand binding site [chemical binding]; other site 693444004234 NAD binding site [chemical binding]; other site 693444004235 catalytic site [active] 693444004236 homodimer interface [polypeptide binding]; other site 693444004237 putative semialdehyde dehydrogenase; Provisional; Region: PRK08040 693444004238 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 693444004239 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 693444004240 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 693444004241 dimerization interface 3.5A [polypeptide binding]; other site 693444004242 active site 693444004243 hypothetical protein; Provisional; Region: PRK10847 693444004244 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 693444004245 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 693444004246 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 693444004247 bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846 693444004248 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 693444004249 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 693444004250 cell division protein DedD; Provisional; Region: PRK11633 693444004251 Sporulation related domain; Region: SPOR; pfam05036 693444004252 colicin V production protein; Provisional; Region: PRK10845 693444004253 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 693444004254 amidophosphoribosyltransferase; Provisional; Region: PRK09246 693444004255 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 693444004256 active site 693444004257 tetramer interface [polypeptide binding]; other site 693444004258 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 693444004259 active site 693444004260 hydrogenase 2 small subunit; Provisional; Region: PRK10468 693444004261 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 693444004262 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 693444004263 hydrogenase 2 protein HybA; Provisional; Region: PRK10882 693444004264 4Fe-4S binding domain; Region: Fer4_6; pfam12837 693444004265 putative hydrogenase 2 b cytochrome subunit; Provisional; Region: PRK10881 693444004266 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 693444004267 hydrogenase 2 large subunit; Provisional; Region: PRK10467 693444004268 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 693444004269 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 693444004270 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 693444004271 putative substrate-binding site; other site 693444004272 nickel binding site [ion binding]; other site 693444004273 hydrogenase 2-specific chaperone; Provisional; Region: PRK10465 693444004274 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 693444004275 hydrogenase nickel incorporation protein HybF; Provisional; Region: PRK12380 693444004276 hydrogenase 2 accessory protein HypG; Provisional; Region: PRK10413 693444004277 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 693444004278 Flavoprotein; Region: Flavoprotein; pfam02441 693444004279 ABC transporter lysine/arginine/ornithine binding periplasmic protein; Provisional; Region: PRK15010 693444004280 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 693444004281 substrate binding pocket [chemical binding]; other site 693444004282 membrane-bound complex binding site; other site 693444004283 hinge residues; other site 693444004284 histidine ABC transporter substrate-binding protein HisJ; Provisional; Region: PRK15437 693444004285 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 693444004286 substrate binding pocket [chemical binding]; other site 693444004287 membrane-bound complex binding site; other site 693444004288 hinge residues; other site 693444004289 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 693444004290 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693444004291 dimer interface [polypeptide binding]; other site 693444004292 conserved gate region; other site 693444004293 putative PBP binding loops; other site 693444004294 ABC-ATPase subunit interface; other site 693444004295 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 693444004296 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693444004297 dimer interface [polypeptide binding]; other site 693444004298 conserved gate region; other site 693444004299 putative PBP binding loops; other site 693444004300 ABC-ATPase subunit interface; other site 693444004301 histidine/lysine/arginine/ornithine transporter subunit; Provisional; Region: PRK10619 693444004302 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 693444004303 Walker A/P-loop; other site 693444004304 ATP binding site [chemical binding]; other site 693444004305 Q-loop/lid; other site 693444004306 ABC transporter signature motif; other site 693444004307 Walker B; other site 693444004308 D-loop; other site 693444004309 H-loop/switch region; other site 693444004310 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 693444004311 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 693444004312 Coenzyme A binding pocket [chemical binding]; other site 693444004313 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 693444004314 TIGR01777 family protein; Region: yfcH 693444004315 putative NAD(P) binding site [chemical binding]; other site 693444004316 putative active site [active] 693444004317 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 693444004318 homooctamer interface [polypeptide binding]; other site 693444004319 active site 693444004320 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 693444004321 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 693444004322 C-terminal domain interface [polypeptide binding]; other site 693444004323 GSH binding site (G-site) [chemical binding]; other site 693444004324 dimer interface [polypeptide binding]; other site 693444004325 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 693444004326 N-terminal domain interface [polypeptide binding]; other site 693444004327 putative dimer interface [polypeptide binding]; other site 693444004328 active site 693444004329 glutathione S-transferase; Provisional; Region: PRK15113 693444004330 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 693444004331 C-terminal domain interface [polypeptide binding]; other site 693444004332 GSH binding site (G-site) [chemical binding]; other site 693444004333 dimer interface [polypeptide binding]; other site 693444004334 C-terminal, alpha helical domain of an unknown subfamily 4 of Glutathione S-transferases; Region: GST_C_4; cd03195 693444004335 N-terminal domain interface [polypeptide binding]; other site 693444004336 putative dimer interface [polypeptide binding]; other site 693444004337 putative substrate binding pocket (H-site) [chemical binding]; other site 693444004338 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 693444004339 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 693444004340 active site 693444004341 metal binding site [ion binding]; metal-binding site 693444004342 homotetramer interface [polypeptide binding]; other site 693444004343 NUDIX hydrolase YfcD; Provisional; Region: PRK15393 693444004344 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_38; cd04697 693444004345 nudix motif; other site 693444004346 phosphate acetyltransferase; Reviewed; Region: PRK05632 693444004347 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 693444004348 DRTGG domain; Region: DRTGG; pfam07085 693444004349 phosphate acetyltransferase; Region: pta; TIGR00651 693444004350 propionate/acetate kinase; Provisional; Region: PRK12379 693444004351 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 693444004352 hypothetical protein; Provisional; Region: PRK01816 693444004353 hypothetical protein; Validated; Region: PRK05445 693444004354 putative phosphatase; Provisional; Region: PRK11587 693444004355 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 693444004356 motif II; other site 693444004357 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 693444004358 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 693444004359 TrkA-C domain; Region: TrkA_C; pfam02080 693444004360 TrkA-C domain; Region: TrkA_C; pfam02080 693444004361 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 693444004362 5'-nucleotidase; Provisional; Region: PRK03826 693444004363 aminotransferase AlaT; Validated; Region: PRK09265 693444004364 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 693444004365 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693444004366 homodimer interface [polypeptide binding]; other site 693444004367 catalytic residue [active] 693444004368 DNA-binding transcriptional repressor LrhA; Provisional; Region: PRK15092 693444004369 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693444004370 The C-terminal substrate domain of LysR-like regulator LrhA (LysR homologue A) and that of closely related homologs, contains the type 2 periplasmic binding fold; Region: PBP2_LrhA_like; cd08439 693444004371 putative dimerization interface [polypeptide binding]; other site 693444004372 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 693444004373 NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases [Energy production and conversion]; Region: NuoB; COG0377 693444004374 bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742 693444004375 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 693444004376 NADH dehydrogenase subunit D; Validated; Region: PRK06075 693444004377 NADH dehydrogenase subunit E; Validated; Region: PRK07539 693444004378 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 693444004379 putative dimer interface [polypeptide binding]; other site 693444004380 [2Fe-2S] cluster binding site [ion binding]; other site 693444004381 NADH dehydrogenase I subunit F; Provisional; Region: PRK11278 693444004382 SLBB domain; Region: SLBB; pfam10531 693444004383 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 693444004384 NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) [Energy production and conversion]; Region: NuoG; COG1034 693444004385 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 693444004386 catalytic loop [active] 693444004387 iron binding site [ion binding]; other site 693444004388 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 693444004389 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 693444004390 [4Fe-4S] binding site [ion binding]; other site 693444004391 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 693444004392 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 693444004393 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 693444004394 4Fe-4S binding domain; Region: Fer4; pfam00037 693444004395 4Fe-4S binding domain; Region: Fer4; pfam00037 693444004396 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 693444004397 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 693444004398 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 693444004399 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 693444004400 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 693444004401 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 693444004402 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 693444004403 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 693444004404 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 693444004405 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 693444004406 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 693444004407 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 693444004408 Coenzyme A binding pocket [chemical binding]; other site 693444004409 hypothetical protein; Provisional; Region: PRK10404 693444004410 menaquinone-specific isochorismate synthase; Provisional; Region: PRK15012 693444004411 chorismate binding enzyme; Region: Chorismate_bind; cl10555 693444004412 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 693444004413 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 693444004414 dimer interface [polypeptide binding]; other site 693444004415 tetramer interface [polypeptide binding]; other site 693444004416 PYR/PP interface [polypeptide binding]; other site 693444004417 TPP binding site [chemical binding]; other site 693444004418 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 693444004419 TPP-binding site; other site 693444004420 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Provisional; Region: PRK11126 693444004421 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 693444004422 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 693444004423 substrate binding site [chemical binding]; other site 693444004424 oxyanion hole (OAH) forming residues; other site 693444004425 trimer interface [polypeptide binding]; other site 693444004426 O-succinylbenzoate synthase; Provisional; Region: PRK05105 693444004427 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 693444004428 active site 693444004429 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK09029 693444004430 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 693444004431 acyl-activating enzyme (AAE) consensus motif; other site 693444004432 putative AMP binding site [chemical binding]; other site 693444004433 putative active site [active] 693444004434 putative CoA binding site [chemical binding]; other site 693444004435 YfaZ precursor; Region: YfaZ; pfam07437 693444004436 hypothetical protein; Provisional; Region: PRK03673 693444004437 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 693444004438 putative MPT binding site; other site 693444004439 Competence-damaged protein; Region: CinA; cl00666 693444004440 glycerol-3-phosphate dehydrogenase, anaerobic, C subunit; Region: glycerol3P_GlpC; TIGR03379 693444004441 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 693444004442 Cysteine-rich domain; Region: CCG; pfam02754 693444004443 Cysteine-rich domain; Region: CCG; pfam02754 693444004444 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; COG3075 693444004445 anaerobic glycerol-3-phosphate dehydrogenase subunit B; Validated; Region: PRK05329 693444004446 sn-glycerol-3-phosphate dehydrogenase subunit A; Provisional; Region: glpA; PRK11101 693444004447 hydroxyglutarate oxidase; Provisional; Region: PRK11728 693444004448 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693444004449 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693444004450 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 693444004451 dimerization interface [polypeptide binding]; other site 693444004452 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693444004453 Major Facilitator Superfamily; Region: MFS_1; pfam07690 693444004454 putative substrate translocation pore; other site 693444004455 hypothetical protein; Provisional; Region: PRK09902 693444004456 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 693444004457 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 693444004458 catalytic loop [active] 693444004459 iron binding site [ion binding]; other site 693444004460 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 693444004461 dimer interface [polypeptide binding]; other site 693444004462 putative radical transfer pathway; other site 693444004463 diiron center [ion binding]; other site 693444004464 tyrosyl radical; other site 693444004465 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09103 693444004466 ATP cone domain; Region: ATP-cone; pfam03477 693444004467 Class I ribonucleotide reductase; Region: RNR_I; cd01679 693444004468 active site 693444004469 dimer interface [polypeptide binding]; other site 693444004470 catalytic residues [active] 693444004471 effector binding site; other site 693444004472 R2 peptide binding site; other site 693444004473 adhesin; Provisional; Region: PRK09752 693444004474 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 693444004475 Autotransporter beta-domain; Region: Autotransporter; pfam03797 693444004476 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 693444004477 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693444004478 S-adenosylmethionine binding site [chemical binding]; other site 693444004479 DNA gyrase subunit A; Validated; Region: PRK05560 693444004480 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 693444004481 CAP-like domain; other site 693444004482 active site 693444004483 primary dimer interface [polypeptide binding]; other site 693444004484 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 693444004485 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 693444004486 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 693444004487 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 693444004488 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 693444004489 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 693444004490 hybrid sensory kinase in two-component regulatory system with RcsB and YojN; Provisional; Region: PRK10841 693444004491 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 693444004492 dimer interface [polypeptide binding]; other site 693444004493 phosphorylation site [posttranslational modification] 693444004494 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693444004495 ATP binding site [chemical binding]; other site 693444004496 Mg2+ binding site [ion binding]; other site 693444004497 G-X-G motif; other site 693444004498 RcsC Alpha-Beta-Loop (ABL); Region: RcsC; pfam09456 693444004499 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693444004500 active site 693444004501 phosphorylation site [posttranslational modification] 693444004502 intermolecular recognition site; other site 693444004503 dimerization interface [polypeptide binding]; other site 693444004504 transcriptional regulator RcsB; Provisional; Region: PRK10840 693444004505 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693444004506 active site 693444004507 phosphorylation site [posttranslational modification] 693444004508 intermolecular recognition site; other site 693444004509 dimerization interface [polypeptide binding]; other site 693444004510 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 693444004511 DNA binding residues [nucleotide binding] 693444004512 dimerization interface [polypeptide binding]; other site 693444004513 phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional; Region: PRK10618 693444004514 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693444004515 ATP binding site [chemical binding]; other site 693444004516 G-X-G motif; other site 693444004517 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 693444004518 putative binding surface; other site 693444004519 active site 693444004520 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 693444004521 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 693444004522 trimer interface [polypeptide binding]; other site 693444004523 eyelet of channel; other site 693444004524 thiamine biosynthesis lipoprotein ApbE; Provisional; Region: PRK10461 693444004525 ApbE family; Region: ApbE; pfam02424 693444004526 bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435 693444004527 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 693444004528 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 693444004529 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 693444004530 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 693444004531 DNA binding site [nucleotide binding] 693444004532 active site 693444004533 alpha-ketoglutarate-dependent dioxygenase AlkB; Provisional; Region: PRK15401 693444004534 multidrug transporter membrane component/ATP-binding component; Provisional; Region: PRK10522 693444004535 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 693444004536 Walker A/P-loop; other site 693444004537 ATP binding site [chemical binding]; other site 693444004538 Q-loop/lid; other site 693444004539 ABC transporter signature motif; other site 693444004540 Walker B; other site 693444004541 D-loop; other site 693444004542 H-loop/switch region; other site 693444004543 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 693444004544 MgtE intracellular N domain; Region: MgtE_N; smart00924 693444004545 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 693444004546 Divalent cation transporter; Region: MgtE; cl00786 693444004547 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 693444004548 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 693444004549 Sulfate transporter family; Region: Sulfate_transp; pfam00916 693444004550 malate:quinone oxidoreductase; Validated; Region: PRK05257 693444004551 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 693444004552 Protease Inhibitor Ecotin; homodimeric protease inhibitor; Region: Ecotin; cd00242 693444004553 secondary substrate binding site; other site 693444004554 primary substrate binding site; other site 693444004555 inhibition loop; other site 693444004556 dimerization interface [polypeptide binding]; other site 693444004557 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 693444004558 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 693444004559 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 693444004560 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 693444004561 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 693444004562 dimer interface [polypeptide binding]; other site 693444004563 ADP-ribose binding site [chemical binding]; other site 693444004564 active site 693444004565 nudix motif; other site 693444004566 metal binding site [ion binding]; metal-binding site 693444004567 4-hydroxyphenylacetate catabolism regulatory protein HpaA; Region: HpaA; TIGR02297 693444004568 Cupin domain; Region: Cupin_2; pfam07883 693444004569 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 693444004570 anthranilate dioxygenase reductase; Provisional; Region: antC; PRK11872 693444004571 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 693444004572 catalytic loop [active] 693444004573 iron binding site [ion binding]; other site 693444004574 Benzoate dioxygenase reductase (BenDO) FAD/NAD binding domain. Oxygenases oxidize hydrocarbons using dioxygen as the oxidant. As a Class I bacterial dioxygenases, benzoate dioxygenase like proteins combine an [2Fe-2S] cluster containing N-terminal...; Region: BenDO_FAD_NAD; cd06209 693444004575 FAD binding pocket [chemical binding]; other site 693444004576 FAD binding motif [chemical binding]; other site 693444004577 phosphate binding motif [ion binding]; other site 693444004578 beta-alpha-beta structure motif; other site 693444004579 NAD binding pocket [chemical binding]; other site 693444004580 Transcriptional regulators [Transcription]; Region: GntR; COG1802 693444004581 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 693444004582 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 693444004583 Cytochrome P450; Region: p450; cl12078 693444004584 Predicted hydrolase of alkaline phosphatase superfamily [General function prediction only]; Region: COG3083 693444004585 Domain of unknown function (DUF3413); Region: DUF3413; pfam11893 693444004586 Sulfatase; Region: Sulfatase; cl17466 693444004587 hypothetical protein; Provisional; Region: PRK13689 693444004588 Nucleoid-associated protein [General function prediction only]; Region: COG3081 693444004589 nucleoid-associated protein NdpA; Validated; Region: PRK00378 693444004590 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 693444004591 5S rRNA interface [nucleotide binding]; other site 693444004592 CTC domain interface [polypeptide binding]; other site 693444004593 L16 interface [polypeptide binding]; other site 693444004594 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 693444004595 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 693444004596 ATP binding site [chemical binding]; other site 693444004597 putative Mg++ binding site [ion binding]; other site 693444004598 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 693444004599 nucleotide binding region [chemical binding]; other site 693444004600 ATP-binding site [chemical binding]; other site 693444004601 Ribosomal L40e family; Region: Ribosomal_L40e; cl00671 693444004602 16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839 693444004603 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 693444004604 RNA binding surface [nucleotide binding]; other site 693444004605 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 693444004606 active site 693444004607 uracil binding [chemical binding]; other site 693444004608 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693444004609 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 693444004610 putative substrate translocation pore; other site 693444004611 hypothetical protein; Provisional; Region: PRK11835 693444004612 microcin C ABC transporter ATP-binding protein YejF; Provisional; Region: PRK15134 693444004613 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 693444004614 Walker A/P-loop; other site 693444004615 ATP binding site [chemical binding]; other site 693444004616 Q-loop/lid; other site 693444004617 ABC transporter signature motif; other site 693444004618 Walker B; other site 693444004619 D-loop; other site 693444004620 H-loop/switch region; other site 693444004621 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 693444004622 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 693444004623 Walker A/P-loop; other site 693444004624 ATP binding site [chemical binding]; other site 693444004625 Q-loop/lid; other site 693444004626 ABC transporter signature motif; other site 693444004627 Walker B; other site 693444004628 D-loop; other site 693444004629 H-loop/switch region; other site 693444004630 microcin C ABC transporter permease; Provisional; Region: PRK15021 693444004631 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693444004632 dimer interface [polypeptide binding]; other site 693444004633 conserved gate region; other site 693444004634 ABC-ATPase subunit interface; other site 693444004635 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 693444004636 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693444004637 dimer interface [polypeptide binding]; other site 693444004638 conserved gate region; other site 693444004639 putative PBP binding loops; other site 693444004640 ABC-ATPase subunit interface; other site 693444004641 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 693444004642 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 693444004643 phage resistance protein; Provisional; Region: PRK10551 693444004644 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 693444004645 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 693444004646 outer membrane lipoprotein; Provisional; Region: spr; PRK10838 693444004647 NlpC/P60 family; Region: NLPC_P60; pfam00877 693444004648 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 693444004649 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 693444004650 active site 693444004651 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 693444004652 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 693444004653 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 693444004654 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 693444004655 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 693444004656 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 693444004657 mannonate dehydratase; Provisional; Region: PRK03906 693444004658 mannonate dehydratase; Region: uxuA; TIGR00695 693444004659 elongation factor P; Provisional; Region: PRK04542 693444004660 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 693444004661 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 693444004662 RNA binding site [nucleotide binding]; other site 693444004663 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 693444004664 RNA binding site [nucleotide binding]; other site 693444004665 Flagellin N-methylase; Region: FliB; cl00497 693444004666 sugar efflux transporter B; Provisional; Region: PRK15011 693444004667 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693444004668 putative substrate translocation pore; other site 693444004669 bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional; Region: PRK11109 693444004670 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 693444004671 active site 693444004672 phosphorylation site [posttranslational modification] 693444004673 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 693444004674 dimerization domain swap beta strand [polypeptide binding]; other site 693444004675 regulatory protein interface [polypeptide binding]; other site 693444004676 active site 693444004677 regulatory phosphorylation site [posttranslational modification]; other site 693444004678 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 693444004679 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 693444004680 putative substrate binding site [chemical binding]; other site 693444004681 putative ATP binding site [chemical binding]; other site 693444004682 PTS system fructose-specific transporter subunits IIBC; Provisional; Region: PRK10712 693444004683 N-terminal domain of the phosphotransferase system fructose-specific component IIB [Carbohydrate transport and metabolism]; Region: COG3925 693444004684 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 693444004685 active site 693444004686 P-loop; other site 693444004687 phosphorylation site [posttranslational modification] 693444004688 PTS system, fructose subfamily, IIC component; Region: PTS_IIC_fructo; TIGR01427 693444004689 endonuclease IV; Provisional; Region: PRK01060 693444004690 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 693444004691 AP (apurinic/apyrimidinic) site pocket; other site 693444004692 DNA interaction; other site 693444004693 Metal-binding active site; metal-binding site 693444004694 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 693444004695 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 693444004696 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693444004697 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 693444004698 putative dimerization interface [polypeptide binding]; other site 693444004699 lysine transporter; Provisional; Region: PRK10836 693444004700 catecholate siderophore receptor CirA; Provisional; Region: PRK10064 693444004701 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 693444004702 N-terminal plug; other site 693444004703 ligand-binding site [chemical binding]; other site 693444004704 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 693444004705 S-formylglutathione hydrolase; Region: PLN02442 693444004706 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693444004707 putative substrate translocation pore; other site 693444004708 GTP cyclohydrolase I; Provisional; Region: PLN03044 693444004709 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 693444004710 active site 693444004711 Predicted membrane protein [Function unknown]; Region: COG2311 693444004712 hypothetical protein; Provisional; Region: PRK10835 693444004713 DNA-binding transcriptional regulator GalS; Provisional; Region: PRK10401 693444004714 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 693444004715 DNA binding site [nucleotide binding] 693444004716 domain linker motif; other site 693444004717 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 693444004718 dimerization interface (closed form) [polypeptide binding]; other site 693444004719 ligand binding site [chemical binding]; other site 693444004720 methyl-galactoside ABC transporter galactose-binding periplasmic protein MglB; Provisional; Region: PRK15395 693444004721 Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539 693444004722 ligand binding site [chemical binding]; other site 693444004723 calcium binding site [ion binding]; other site 693444004724 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 693444004725 galactose/methyl galaxtoside transporter ATP-binding protein; Provisional; Region: PRK10982 693444004726 Walker A/P-loop; other site 693444004727 ATP binding site [chemical binding]; other site 693444004728 Q-loop/lid; other site 693444004729 ABC transporter signature motif; other site 693444004730 Walker B; other site 693444004731 D-loop; other site 693444004732 H-loop/switch region; other site 693444004733 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 693444004734 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 693444004735 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 693444004736 TM-ABC transporter signature motif; other site 693444004737 dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318 693444004738 Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940 693444004739 homodimer interface [polypeptide binding]; other site 693444004740 active site 693444004741 FMN binding site [chemical binding]; other site 693444004742 substrate binding site [chemical binding]; other site 693444004743 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 693444004744 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 693444004745 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 693444004746 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 693444004747 putative active site [active] 693444004748 cytidine deaminase; Provisional; Region: PRK09027 693444004749 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 693444004750 active site 693444004751 catalytic motif [active] 693444004752 Zn binding site [ion binding]; other site 693444004753 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 693444004754 active site 693444004755 catalytic motif [active] 693444004756 Zn binding site [ion binding]; other site 693444004757 hypothetical protein; Provisional; Region: PRK10711 693444004758 hypothetical protein; Provisional; Region: PRK01821 693444004759 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 693444004760 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693444004761 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 693444004762 dimerization interface [polypeptide binding]; other site 693444004763 benzoate transport; Region: 2A0115; TIGR00895 693444004764 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693444004765 putative substrate translocation pore; other site 693444004766 gentisate 1,2-dioxygenase; Region: gentisate_1_2; TIGR02272 693444004767 Cupin domain; Region: Cupin_2; pfam07883 693444004768 Cupin domain; Region: Cupin_2; cl17218 693444004769 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 693444004770 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 693444004771 GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042 693444004772 maleylacetoacetate isomerase; Region: maiA; TIGR01262 693444004773 C-terminal domain interface [polypeptide binding]; other site 693444004774 GSH binding site (G-site) [chemical binding]; other site 693444004775 putative dimer interface [polypeptide binding]; other site 693444004776 C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191 693444004777 dimer interface [polypeptide binding]; other site 693444004778 N-terminal domain interface [polypeptide binding]; other site 693444004779 maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site 693444004780 salicylate hydroxylase; Provisional; Region: PRK08163 693444004781 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 693444004782 tRNA-dihydrouridine synthase C; Provisional; Region: PRK10550 693444004783 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 693444004784 FMN binding site [chemical binding]; other site 693444004785 active site 693444004786 catalytic residues [active] 693444004787 substrate binding site [chemical binding]; other site 693444004788 Methyltransferase domain; Region: Methyltransf_31; pfam13847 693444004789 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693444004790 S-adenosylmethionine binding site [chemical binding]; other site 693444004791 multidrug resistance outer membrane protein MdtQ; Provisional; Region: PRK11459 693444004792 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 693444004793 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 693444004794 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 693444004795 Protein of unknown function (DUF1282); Region: DUF1282; pfam06930 693444004796 D-alanyl-D-alanine endopeptidase; Provisional; Region: pbpG; PRK11669 693444004797 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 693444004798 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 693444004799 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 693444004800 Coenzyme A binding pocket [chemical binding]; other site 693444004801 D-lactate dehydrogenase; Provisional; Region: PRK11183 693444004802 FAD binding domain; Region: FAD_binding_4; pfam01565 693444004803 D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330 693444004804 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 693444004805 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 693444004806 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 693444004807 Endopygalactorunase [Cell envelope biogenesis, outer membrane]; Region: PGU1; COG5434 693444004808 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 693444004809 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 693444004810 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 693444004811 polyol permease family; Region: 2A0118; TIGR00897 693444004812 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693444004813 putative substrate translocation pore; other site 693444004814 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 693444004815 fimbrial assembly chaperone StbE; Provisional; Region: PRK15246 693444004816 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 693444004817 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 693444004818 Fimbrial protein; Region: Fimbrial; cl01416 693444004819 fimbrial outer membrane usher protein StbC; Provisional; Region: PRK15248 693444004820 PapC N-terminal domain; Region: PapC_N; pfam13954 693444004821 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 693444004822 PapC C-terminal domain; Region: PapC_C; pfam13953 693444004823 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 693444004824 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 693444004825 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 693444004826 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 693444004827 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 693444004828 DNA binding site [nucleotide binding] 693444004829 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 693444004830 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 693444004831 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 693444004832 Walker A/P-loop; other site 693444004833 ATP binding site [chemical binding]; other site 693444004834 Q-loop/lid; other site 693444004835 ABC transporter signature motif; other site 693444004836 Walker B; other site 693444004837 D-loop; other site 693444004838 H-loop/switch region; other site 693444004839 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 693444004840 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693444004841 dimer interface [polypeptide binding]; other site 693444004842 conserved gate region; other site 693444004843 putative PBP binding loops; other site 693444004844 ABC-ATPase subunit interface; other site 693444004845 hypothetical protein; Provisional; Region: PRK13681 693444004846 transcriptional regulator MirA; Provisional; Region: PRK15043 693444004847 Helix-Turn-Helix DNA binding domain of MlrA-like transcription regulators; Region: HTH_MlrA-like; cd04763 693444004848 DNA binding residues [nucleotide binding] 693444004849 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 693444004850 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 693444004851 GAF domain; Region: GAF; pfam01590 693444004852 Histidine kinase; Region: His_kinase; pfam06580 693444004853 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693444004854 ATP binding site [chemical binding]; other site 693444004855 Mg2+ binding site [ion binding]; other site 693444004856 G-X-G motif; other site 693444004857 putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697 693444004858 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693444004859 active site 693444004860 phosphorylation site [posttranslational modification] 693444004861 intermolecular recognition site; other site 693444004862 dimerization interface [polypeptide binding]; other site 693444004863 LytTr DNA-binding domain; Region: LytTR; pfam04397 693444004864 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807 693444004865 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 693444004866 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 693444004867 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4808 693444004868 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 693444004869 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 693444004870 active site 693444004871 HIGH motif; other site 693444004872 KMSKS motif; other site 693444004873 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 693444004874 tRNA binding surface [nucleotide binding]; other site 693444004875 anticodon binding site; other site 693444004876 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 693444004877 dimer interface [polypeptide binding]; other site 693444004878 putative tRNA-binding site [nucleotide binding]; other site 693444004879 antiporter inner membrane protein; Provisional; Region: PRK11670 693444004880 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 693444004881 Walker A motif; other site 693444004882 Predicted integral membrane protein [Function unknown]; Region: COG5455 693444004883 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 693444004884 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 693444004885 putative NAD(P) binding site [chemical binding]; other site 693444004886 dimer interface [polypeptide binding]; other site 693444004887 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693444004888 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693444004889 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 693444004890 putative effector binding pocket; other site 693444004891 dimerization interface [polypeptide binding]; other site 693444004892 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 693444004893 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 693444004894 DNA-binding site [nucleotide binding]; DNA binding site 693444004895 UTRA domain; Region: UTRA; pfam07702 693444004896 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 693444004897 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 693444004898 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 693444004899 active site 693444004900 P-loop; other site 693444004901 phosphorylation site [posttranslational modification] 693444004902 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 693444004903 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 693444004904 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 693444004905 active site 693444004906 P-loop; other site 693444004907 phosphorylation site [posttranslational modification] 693444004908 putative oxidoreductase; Provisional; Region: PRK10206 693444004909 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 693444004910 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 693444004911 chromosome condensation membrane protein; Provisional; Region: PRK14196 693444004912 Universal stress protein family; Region: Usp; pfam00582 693444004913 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 693444004914 substrate binding site [chemical binding]; other site 693444004915 multimerization interface [polypeptide binding]; other site 693444004916 ATP binding site [chemical binding]; other site 693444004917 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 693444004918 dimer interface [polypeptide binding]; other site 693444004919 substrate binding site [chemical binding]; other site 693444004920 ATP binding site [chemical binding]; other site 693444004921 Hok/gef family; Region: HOK_GEF; pfam01848 693444004922 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 693444004923 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 693444004924 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 693444004925 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 693444004926 active site 693444004927 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 693444004928 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693444004929 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693444004930 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 693444004931 dimerization interface [polypeptide binding]; other site 693444004932 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 693444004933 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 693444004934 DNA-binding site [nucleotide binding]; DNA binding site 693444004935 UTRA domain; Region: UTRA; pfam07702 693444004936 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 693444004937 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 693444004938 substrate binding site [chemical binding]; other site 693444004939 ATP binding site [chemical binding]; other site 693444004940 ADP-ribosylglycohydrolase [Posttranslational modification, protein turnover, chaperones]; Region: DraG; COG1397 693444004941 nucleoside transporter; Region: 2A0110; TIGR00889 693444004942 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693444004943 putative substrate translocation pore; other site 693444004944 fructose-bisphosphate aldolase; Provisional; Region: PRK09250 693444004945 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 693444004946 putative active site; other site 693444004947 catalytic residue [active] 693444004948 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 693444004949 Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 4. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_4; cd03329 693444004950 putative active site pocket [active] 693444004951 metal binding site [ion binding]; metal-binding site 693444004952 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 693444004953 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 693444004954 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 693444004955 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693444004956 dimer interface [polypeptide binding]; other site 693444004957 conserved gate region; other site 693444004958 putative PBP binding loops; other site 693444004959 ABC-ATPase subunit interface; other site 693444004960 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 693444004961 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 693444004962 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693444004963 dimer interface [polypeptide binding]; other site 693444004964 conserved gate region; other site 693444004965 ABC-ATPase subunit interface; other site 693444004966 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 693444004967 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 693444004968 Walker A/P-loop; other site 693444004969 ATP binding site [chemical binding]; other site 693444004970 Q-loop/lid; other site 693444004971 ABC transporter signature motif; other site 693444004972 Walker B; other site 693444004973 D-loop; other site 693444004974 H-loop/switch region; other site 693444004975 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 693444004976 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 693444004977 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 693444004978 Walker A/P-loop; other site 693444004979 ATP binding site [chemical binding]; other site 693444004980 Q-loop/lid; other site 693444004981 ABC transporter signature motif; other site 693444004982 Walker B; other site 693444004983 D-loop; other site 693444004984 H-loop/switch region; other site 693444004985 lipid kinase; Reviewed; Region: PRK13054 693444004986 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 693444004987 putative protease; Provisional; Region: PRK15452 693444004988 Peptidase family U32; Region: Peptidase_U32; pfam01136 693444004989 DNA-binding transcriptional regulator BaeR; Provisional; Region: PRK10710 693444004990 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693444004991 active site 693444004992 phosphorylation site [posttranslational modification] 693444004993 intermolecular recognition site; other site 693444004994 dimerization interface [polypeptide binding]; other site 693444004995 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 693444004996 DNA binding site [nucleotide binding] 693444004997 signal transduction histidine-protein kinase BaeS; Provisional; Region: PRK10549 693444004998 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 693444004999 dimerization interface [polypeptide binding]; other site 693444005000 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 693444005001 dimer interface [polypeptide binding]; other site 693444005002 phosphorylation site [posttranslational modification] 693444005003 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693444005004 ATP binding site [chemical binding]; other site 693444005005 Mg2+ binding site [ion binding]; other site 693444005006 G-X-G motif; other site 693444005007 putative transporter; Provisional; Region: PRK10504 693444005008 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693444005009 putative substrate translocation pore; other site 693444005010 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693444005011 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 693444005012 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 693444005013 Protein export membrane protein; Region: SecD_SecF; cl14618 693444005014 multidrug efflux system subunit MdtA; Provisional; Region: PRK11556 693444005015 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 693444005016 HlyD family secretion protein; Region: HlyD_3; pfam13437 693444005017 putative chaperone; Provisional; Region: PRK11678 693444005018 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 693444005019 nucleotide binding site [chemical binding]; other site 693444005020 putative NEF/HSP70 interaction site [polypeptide binding]; other site 693444005021 SBD interface [polypeptide binding]; other site 693444005022 3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308 693444005023 AlkA N-terminal domain; Region: AlkA_N; pfam06029 693444005024 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 693444005025 minor groove reading motif; other site 693444005026 helix-hairpin-helix signature motif; other site 693444005027 substrate binding pocket [chemical binding]; other site 693444005028 active site 693444005029 Predicted integral membrane sensor domain [Signal transduction mechanisms]; Region: COG3447 693444005030 PAS domain S-box; Region: sensory_box; TIGR00229 693444005031 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 693444005032 putative active site [active] 693444005033 heme pocket [chemical binding]; other site 693444005034 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 693444005035 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 693444005036 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 693444005037 putative active site [active] 693444005038 heme pocket [chemical binding]; other site 693444005039 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 693444005040 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693444005041 metal binding site [ion binding]; metal-binding site 693444005042 active site 693444005043 I-site; other site 693444005044 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 693444005045 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 693444005046 ATP-binding site [chemical binding]; other site 693444005047 Sugar specificity; other site 693444005048 Pyrimidine base specificity; other site 693444005049 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 693444005050 trimer interface [polypeptide binding]; other site 693444005051 active site 693444005052 putative assembly protein; Provisional; Region: PRK10833 693444005053 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 693444005054 chaperone-modulator protein CbpM; Provisional; Region: PRK10265 693444005055 MerR HTH family regulatory protein; Region: MerR_2; pfam13591 693444005056 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 693444005057 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 693444005058 HSP70 interaction site [polypeptide binding]; other site 693444005059 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 693444005060 substrate binding site [polypeptide binding]; other site 693444005061 dimer interface [polypeptide binding]; other site 693444005062 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 693444005063 FOG: CBS domain [General function prediction only]; Region: COG0517 693444005064 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 693444005065 Transporter associated domain; Region: CorC_HlyC; smart01091 693444005066 polysaccharide export protein Wza; Provisional; Region: PRK15078 693444005067 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 693444005068 SLBB domain; Region: SLBB; pfam10531 693444005069 Low molecular weight phosphatase family; Region: LMWPc; cd00115 693444005070 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 693444005071 active site 693444005072 tyrosine kinase; Provisional; Region: PRK11519 693444005073 Chain length determinant protein; Region: Wzz; pfam02706 693444005074 Chain length determinant protein; Region: Wzz; cl15801 693444005075 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 693444005076 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 693444005077 putative glycosyl transferase; Provisional; Region: PRK10018 693444005078 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 693444005079 active site 693444005080 putative acyl transferase; Provisional; Region: PRK10191 693444005081 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 693444005082 trimer interface [polypeptide binding]; other site 693444005083 active site 693444005084 substrate binding site [chemical binding]; other site 693444005085 CoA binding site [chemical binding]; other site 693444005086 colanic acid biosynthesis glycosyl transferase WcaC; Region: WcaC; TIGR04015 693444005087 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 693444005088 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 693444005089 putative colanic acid biosynthesis protein; Provisional; Region: wcaD; cl08075 693444005090 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 693444005091 putative glycosyl transferase; Provisional; Region: PRK10063 693444005092 active site 693444005093 colanic acid biosynthesis acetyltransferase WcaF; Region: WcaF; TIGR04008 693444005094 wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825 693444005095 putative trimer interface [polypeptide binding]; other site 693444005096 putative active site [active] 693444005097 putative substrate binding site [chemical binding]; other site 693444005098 putative CoA binding site [chemical binding]; other site 693444005099 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 693444005100 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 693444005101 NADP-binding site; other site 693444005102 homotetramer interface [polypeptide binding]; other site 693444005103 substrate binding site [chemical binding]; other site 693444005104 homodimer interface [polypeptide binding]; other site 693444005105 active site 693444005106 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 693444005107 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 693444005108 NADP binding site [chemical binding]; other site 693444005109 active site 693444005110 putative substrate binding site [chemical binding]; other site 693444005111 GDP-mannose glycosyl hydrolase (AKA GDP-mannose mannosyl hydrolase (GDPMH)) is a member of the Nudix hydrolase superfamily. This class of enzymes is unique from other members of the superfamily in two aspects. First, it contains a modified Nudix...; Region: GDPMH; cd03430 693444005112 active site 693444005113 GDP-Mannose binding site [chemical binding]; other site 693444005114 dimer interface [polypeptide binding]; other site 693444005115 modified nudix motif 693444005116 metal binding site [ion binding]; metal-binding site 693444005117 colanic acid biosynthesis glycosyl transferase WcaI; Region: wcaI; TIGR04007 693444005118 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 693444005119 mannose-1-phosphate guanyltransferase; Provisional; Region: cpsB; PRK15460 693444005120 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 693444005121 Substrate binding site; other site 693444005122 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 693444005123 phosphomannomutase CpsG; Provisional; Region: PRK15414 693444005124 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 693444005125 active site 693444005126 substrate binding site [chemical binding]; other site 693444005127 metal binding site [ion binding]; metal-binding site 693444005128 putative UDP-glucose lipid carrier transferase; Provisional; Region: PRK10124 693444005129 Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148 693444005130 colanic acid exporter; Provisional; Region: PRK10459 693444005131 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 693444005132 colanic acid biosynthesis pyruvyl transferase WcaK; Region: wcaK; TIGR04006 693444005133 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327 693444005134 colanic acid biosynthesis glycosyltransferase WcaL; Provisional; Region: PRK15427 693444005135 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 693444005136 putative ADP-binding pocket [chemical binding]; other site 693444005137 putative colanic acid biosynthesis protein; Provisional; Region: wcaM; PRK10123 693444005138 TAT (twin-arginine translocation) pathway signal sequence; Region: TAT_signal; pfam10518 693444005139 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 693444005140 active site 693444005141 tetramer interface; other site 693444005142 UDP-N-acetylglucosamine 4,6-dehydratase; Region: PseB; TIGR03589 693444005143 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 693444005144 NAD(P) binding site [chemical binding]; other site 693444005145 homodimer interface [polypeptide binding]; other site 693444005146 substrate binding site [chemical binding]; other site 693444005147 active site 693444005148 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 693444005149 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 693444005150 inhibitor-cofactor binding pocket; inhibition site 693444005151 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693444005152 catalytic residue [active] 693444005153 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 693444005154 ligand binding site; other site 693444005155 tetramer interface; other site 693444005156 pseudaminic acid biosynthesis-associated protein PseG; Region: PseG; TIGR03590 693444005157 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 693444005158 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 693444005159 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 693444005160 pseudaminic acid synthase; Region: PseI; TIGR03586 693444005161 NeuB family; Region: NeuB; pfam03102 693444005162 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 693444005163 NeuB binding interface [polypeptide binding]; other site 693444005164 putative substrate binding site [chemical binding]; other site 693444005165 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 693444005166 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 693444005167 Glycosyltransferase family 52; Region: Glyco_transf_52; pfam07922 693444005168 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 693444005169 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 693444005170 active site 693444005171 Domain of unknown function (DUF4422); Region: DUF4422; pfam14393 693444005172 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 693444005173 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 693444005174 UDP-galactopyranose mutase; Region: GLF; pfam03275 693444005175 undecaprenyl-phosphate galactose phosphotransferase; Provisional; Region: PRK15204 693444005176 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 693444005177 Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148 693444005178 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 693444005179 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 693444005180 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 693444005181 UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057 693444005182 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 693444005183 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 693444005184 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 693444005185 chain length determinant protein WzzB; Provisional; Region: PRK15471 693444005186 Chain length determinant protein; Region: Wzz; pfam02706 693444005187 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 693444005188 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 693444005189 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 693444005190 metal binding site [ion binding]; metal-binding site 693444005191 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 693444005192 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 693444005193 substrate binding site [chemical binding]; other site 693444005194 glutamase interaction surface [polypeptide binding]; other site 693444005195 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 693444005196 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 693444005197 catalytic residues [active] 693444005198 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13170 693444005199 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 693444005200 putative active site [active] 693444005201 oxyanion strand; other site 693444005202 catalytic triad [active] 693444005203 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446 693444005204 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 693444005205 active site 693444005206 motif I; other site 693444005207 motif II; other site 693444005208 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 693444005209 putative active site pocket [active] 693444005210 4-fold oligomerization interface [polypeptide binding]; other site 693444005211 metal binding residues [ion binding]; metal-binding site 693444005212 3-fold/trimer interface [polypeptide binding]; other site 693444005213 histidinol-phosphate aminotransferase; Provisional; Region: PRK01688 693444005214 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 693444005215 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693444005216 homodimer interface [polypeptide binding]; other site 693444005217 catalytic residue [active] 693444005218 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 693444005219 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 693444005220 NAD binding site [chemical binding]; other site 693444005221 dimerization interface [polypeptide binding]; other site 693444005222 product binding site; other site 693444005223 substrate binding site [chemical binding]; other site 693444005224 zinc binding site [ion binding]; other site 693444005225 catalytic residues [active] 693444005226 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 693444005227 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 693444005228 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 693444005229 Histidine operon leader; D782_1608; IMG reference gene:2507516304 693444005230 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 693444005231 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 693444005232 putative NAD(P) binding site [chemical binding]; other site 693444005233 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693444005234 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693444005235 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 693444005236 dimerization interface [polypeptide binding]; other site 693444005237 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 693444005238 putative selenium metabolism protein, YedE family; Region: seleno_YedE; TIGR04112 693444005239 Sulphur transport; Region: Sulf_transp; pfam04143 693444005240 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 693444005241 CPxP motif; other site 693444005242 exonuclease I; Provisional; Region: sbcB; PRK11779 693444005243 N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138 693444005244 active site 693444005245 catalytic site [active] 693444005246 substrate binding site [chemical binding]; other site 693444005247 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 693444005248 D-alanyl-D-alanine carboxypeptidase; Provisional; Region: dacD; PRK11397 693444005249 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 693444005250 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 693444005251 DNA gyrase inhibitor; Provisional; Region: PRK10016 693444005252 Predicted membrane protein [Function unknown]; Region: COG1289 693444005253 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 693444005254 hypothetical protein; Provisional; Region: PRK05423 693444005255 Protein involved in propanediol utilization, and related proteins (includes coumermycin biosynthetic protein), possible kinase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduX; COG4542 693444005256 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 693444005257 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 693444005258 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 693444005259 catalytic triad [active] 693444005260 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 693444005261 cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; PRK08286 693444005262 Precorrin-8X methylmutase; Region: CbiC; pfam02570 693444005263 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 693444005264 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 693444005265 active site 693444005266 putative homodimer interface [polypeptide binding]; other site 693444005267 SAM binding site [chemical binding]; other site 693444005268 cobalt-precorrin-6Y C(15)-methyltransferase; Validated; Region: PRK08287 693444005269 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693444005270 S-adenosylmethionine binding site [chemical binding]; other site 693444005271 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 693444005272 active site 693444005273 SAM binding site [chemical binding]; other site 693444005274 homodimer interface [polypeptide binding]; other site 693444005275 cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788 693444005276 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 693444005277 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 693444005278 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 693444005279 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 693444005280 active site 693444005281 SAM binding site [chemical binding]; other site 693444005282 homodimer interface [polypeptide binding]; other site 693444005283 cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057 693444005284 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 693444005285 Cobalamin biosynthesis protein CbiK, Co2+ chelatase [Coenzyme metabolism]; Region: CbiK; COG4822 693444005286 Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), N-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_N; cd03412 693444005287 active site 693444005288 C-terminal domain interface [polypeptide binding]; other site 693444005289 Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), C-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_C; cd03413 693444005290 active site 693444005291 N-terminal domain interface [polypeptide binding]; other site 693444005292 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 693444005293 active site 693444005294 SAM binding site [chemical binding]; other site 693444005295 homodimer interface [polypeptide binding]; other site 693444005296 cobalt transport protein CbiM; Validated; Region: PRK08319 693444005297 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 693444005298 cobalt transport protein CbiN; Provisional; Region: PRK02898 693444005299 cobalt transport protein CbiQ; Provisional; Region: PRK15485 693444005300 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13638 693444005301 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 693444005302 Walker A/P-loop; other site 693444005303 ATP binding site [chemical binding]; other site 693444005304 Q-loop/lid; other site 693444005305 ABC transporter signature motif; other site 693444005306 Walker B; other site 693444005307 D-loop; other site 693444005308 H-loop/switch region; other site 693444005309 cobyric acid synthase; Provisional; Region: PRK00784 693444005310 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 693444005311 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 693444005312 catalytic triad [active] 693444005313 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 693444005314 homotrimer interface [polypeptide binding]; other site 693444005315 Walker A motif; other site 693444005316 GTP binding site [chemical binding]; other site 693444005317 Walker B motif; other site 693444005318 cobalamin synthase; Reviewed; Region: cobS; PRK00235 693444005319 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 693444005320 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 693444005321 putative dimer interface [polypeptide binding]; other site 693444005322 active site pocket [active] 693444005323 putative cataytic base [active] 693444005324 L,D-transpeptidase; Provisional; Region: PRK10190 693444005325 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 693444005326 MATE family multidrug exporter; Provisional; Region: PRK10189 693444005327 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 693444005328 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 693444005329 non-specific DNA binding site [nucleotide binding]; other site 693444005330 salt bridge; other site 693444005331 sequence-specific DNA binding site [nucleotide binding]; other site 693444005332 AMP nucleosidase; Provisional; Region: PRK08292 693444005333 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 693444005334 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 693444005335 shikimate transporter; Provisional; Region: PRK09952 693444005336 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693444005337 putative substrate translocation pore; other site 693444005338 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 693444005339 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 693444005340 nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233 693444005341 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693444005342 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 693444005343 putative dimerization interface [polypeptide binding]; other site 693444005344 transcriptional regulator Cbl; Reviewed; Region: cbl; PRK12679 693444005345 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 693444005346 dimerization interface [polypeptide binding]; other site 693444005347 DgsA anti-repressor MtfA; Provisional; Region: PRK15410 693444005348 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 693444005349 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 693444005350 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 693444005351 Glycogen synthesis protein; Region: GlgS; cl11663 693444005352 Transmembrane secretion effector; Region: MFS_3; pfam05977 693444005353 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693444005354 putative substrate translocation pore; other site 693444005355 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 693444005356 hydrophobic ligand binding site; other site 693444005357 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693444005358 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693444005359 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_3; cd08461 693444005360 putative substrate binding pocket [chemical binding]; other site 693444005361 putative dimerization interface [polypeptide binding]; other site 693444005362 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 693444005363 putative DNA binding site [nucleotide binding]; other site 693444005364 dimerization interface [polypeptide binding]; other site 693444005365 putative Zn2+ binding site [ion binding]; other site 693444005366 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 693444005367 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 693444005368 FMN binding site [chemical binding]; other site 693444005369 active site 693444005370 substrate binding site [chemical binding]; other site 693444005371 catalytic residue [active] 693444005372 Uncharacterized protein family (UPF0257); Region: UPF0257; cl14672 693444005373 fumarate hydratase; Provisional; Region: PRK15389 693444005374 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 693444005375 Fumarase C-terminus; Region: Fumerase_C; pfam05683 693444005376 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 693444005377 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 693444005378 transmembrane helices; other site 693444005379 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 693444005380 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 693444005381 putative active site [active] 693444005382 putative FMN binding site [chemical binding]; other site 693444005383 putative substrate binding site [chemical binding]; other site 693444005384 putative catalytic residue [active] 693444005385 FMN-binding domain; Region: FMN_bind; cl01081 693444005386 fumarate reductase flavoprotein subunit; Validated; Region: PRK06481 693444005387 L-aspartate oxidase; Provisional; Region: PRK06175 693444005388 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 693444005389 ApbE family; Region: ApbE; pfam02424 693444005390 DNA-binding transcriptional activator DcuR; Provisional; Region: PRK10430 693444005391 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693444005392 active site 693444005393 phosphorylation site [posttranslational modification] 693444005394 intermolecular recognition site; other site 693444005395 dimerization interface [polypeptide binding]; other site 693444005396 sensory histidine kinase DcuS; Provisional; Region: PRK11086 693444005397 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693444005398 ATP binding site [chemical binding]; other site 693444005399 Mg2+ binding site [ion binding]; other site 693444005400 G-X-G motif; other site 693444005401 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 693444005402 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 693444005403 putative active site [active] 693444005404 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 693444005405 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 693444005406 trimer interface [polypeptide binding]; other site 693444005407 eyelet of channel; other site 693444005408 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 693444005409 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 693444005410 Zn2+ binding site [ion binding]; other site 693444005411 Mg2+ binding site [ion binding]; other site 693444005412 DNA cytosine methylase; Provisional; Region: PRK10458 693444005413 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 693444005414 cofactor binding site; other site 693444005415 DNA binding site [nucleotide binding] 693444005416 substrate interaction site [chemical binding]; other site 693444005417 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 693444005418 additional DNA contacts [nucleotide binding]; other site 693444005419 mismatch recognition site; other site 693444005420 active site 693444005421 zinc binding site [ion binding]; other site 693444005422 DNA intercalation site [nucleotide binding]; other site 693444005423 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 693444005424 EamA-like transporter family; Region: EamA; pfam00892 693444005425 hypothetical protein; Provisional; Region: PRK10062 693444005426 Uncharacterized small protein (DUF2158); Region: DUF2158; cl02293 693444005427 mannosyl-3-phosphoglycerate phosphatase; Reviewed; Region: PRK03669 693444005428 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 693444005429 active site 693444005430 motif I; other site 693444005431 motif II; other site 693444005432 Protein of unknown function (DUF2525); Region: DUF2525; pfam10733 693444005433 hypothetical protein; Provisional; Region: PRK10708 693444005434 colanic acid capsular biosynthesis activation protein A; Provisional; Region: rcsA; PRK15411 693444005435 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 693444005436 DNA binding residues [nucleotide binding] 693444005437 dimerization interface [polypeptide binding]; other site 693444005438 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 693444005439 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 693444005440 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 693444005441 flagellar biosynthesis protein FliO; Provisional; Region: PRK11486 693444005442 flagellar motor switch protein FliN; Validated; Region: fliN; PRK07963 693444005443 flagellar motor switch protein; Validated; Region: fliN; PRK05698 693444005444 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 693444005445 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 693444005446 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07021 693444005447 Flagellar hook-length control protein FliK; Region: Flg_hook; cl17777 693444005448 Flagellar hook-length control protein [Cell motility and secretion]; Region: FliK; COG3144 693444005449 Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882 693444005450 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689 693444005451 flagellum-specific ATP synthase; Validated; Region: fliI; PRK07960 693444005452 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 693444005453 Walker A motif/ATP binding site; other site 693444005454 Walker B motif; other site 693444005455 flagellar assembly protein H; Validated; Region: fliH; PRK05687 693444005456 Flagellar assembly protein FliH; Region: FliH; pfam02108 693444005457 flagellar motor switch protein FliG; Region: fliG; TIGR00207 693444005458 FliG C-terminal domain; Region: FliG_C; pfam01706 693444005459 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 693444005460 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514 693444005461 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 693444005462 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00253 693444005463 YedF is a bacterial SirA-like protein of unknown function. SirA (also known as UvrY, and YhhP) belongs to a family of a two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system...; Region: YedF; cd03422 693444005464 CPxP motif; other site 693444005465 putative inner membrane protein; Provisional; Region: PRK11099 693444005466 lipoprotein; Provisional; Region: PRK10397 693444005467 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 693444005468 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 693444005469 active site 693444005470 Na/Ca binding site [ion binding]; other site 693444005471 catalytic site [active] 693444005472 flagellar biosynthesis protein FliT; Provisional; Region: PRK10548 693444005473 flagellar protein FliS; Validated; Region: fliS; PRK05685 693444005474 flagellar capping protein; Reviewed; Region: fliD; PRK08032 693444005475 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 693444005476 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 693444005477 flagellin; Validated; Region: PRK06819 693444005478 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 693444005479 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 693444005480 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 693444005481 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 693444005482 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 693444005483 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 693444005484 DNA binding residues [nucleotide binding] 693444005485 flagella biosynthesis protein FliZ; Provisional; Region: PRK11582 693444005486 cystine transporter subunit; Provisional; Region: PRK11260 693444005487 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 693444005488 substrate binding pocket [chemical binding]; other site 693444005489 membrane-bound complex binding site; other site 693444005490 hinge residues; other site 693444005491 D-cysteine desulfhydrase; Validated; Region: PRK03910 693444005492 Aminocyclopropane-1-carboxylate deaminase (ACCD): Pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of 1-aminocyclopropane-L-carboxylate (ACC), a precursor of the plant hormone ethylene, to alpha-ketobutyrate and ammonia; Region: ACCD; cd06449 693444005493 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693444005494 catalytic residue [active] 693444005495 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 693444005496 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693444005497 dimer interface [polypeptide binding]; other site 693444005498 conserved gate region; other site 693444005499 putative PBP binding loops; other site 693444005500 ABC-ATPase subunit interface; other site 693444005501 putative amino-acid ABC transporter ATP-binding protein YecC; Provisional; Region: PRK11264 693444005502 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 693444005503 Walker A/P-loop; other site 693444005504 ATP binding site [chemical binding]; other site 693444005505 Q-loop/lid; other site 693444005506 ABC transporter signature motif; other site 693444005507 Walker B; other site 693444005508 D-loop; other site 693444005509 H-loop/switch region; other site 693444005510 DNA-binding transcriptional activator SdiA; Provisional; Region: PRK10188 693444005511 Autoinducer binding domain; Region: Autoind_bind; pfam03472 693444005512 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 693444005513 DNA binding residues [nucleotide binding] 693444005514 dimerization interface [polypeptide binding]; other site 693444005515 hypothetical protein; Provisional; Region: PRK10613 693444005516 response regulator; Provisional; Region: PRK09483 693444005517 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693444005518 active site 693444005519 phosphorylation site [posttranslational modification] 693444005520 intermolecular recognition site; other site 693444005521 dimerization interface [polypeptide binding]; other site 693444005522 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 693444005523 DNA binding residues [nucleotide binding] 693444005524 dimerization interface [polypeptide binding]; other site 693444005525 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 693444005526 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 693444005527 GIY-YIG motif/motif A; other site 693444005528 active site 693444005529 catalytic site [active] 693444005530 putative DNA binding site [nucleotide binding]; other site 693444005531 metal binding site [ion binding]; metal-binding site 693444005532 UvrB/uvrC motif; Region: UVR; pfam02151 693444005533 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 693444005534 phosphatidylglycerophosphate synthetase; Provisional; Region: PRK10832 693444005535 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 693444005536 catalytic residue [active] 693444005537 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 693444005538 hypothetical protein; Provisional; Region: PRK10396 693444005539 yecA family protein; Region: ygfB_yecA; TIGR02292 693444005540 SEC-C motif; Region: SEC-C; pfam02810 693444005541 tyrosine transporter TyrP; Provisional; Region: PRK15132 693444005542 aromatic amino acid transport protein; Region: araaP; TIGR00837 693444005543 probable metal-binding protein; Region: matur_matur; TIGR03853 693444005544 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 693444005545 Ferritin-like domain; Region: Ferritin; pfam00210 693444005546 ferroxidase diiron center [ion binding]; other site 693444005547 YecR-like lipoprotein; Region: YecR; pfam13992 693444005548 hypothetical protein; Provisional; Region: PRK09273 693444005549 Ribose 5-phosphate isomerase RpiB [Carbohydrate transport and metabolism]; Region: RpiB; COG0698 693444005550 Ribose-5-phosphate isomerase; Region: DUF3666; pfam12408 693444005551 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693444005552 putative transporter; Provisional; Region: PRK10504 693444005553 putative substrate translocation pore; other site 693444005554 Protein of unknown function (DUF2766); Region: DUF2766; pfam10964 693444005555 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 693444005556 Ferritin-like domain; Region: Ferritin; pfam00210 693444005557 ferroxidase diiron center [ion binding]; other site 693444005558 DJ-1 family protein; Region: not_thiJ; TIGR01383 693444005559 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 693444005560 conserved cys residue [active] 693444005561 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 693444005562 Periplasmic L-arabinose-binding protein (ABP), a member of a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein superfamily; Region: PBP1_arabinose_binding; cd01540 693444005563 ligand binding site [chemical binding]; other site 693444005564 L-arabinose transporter ATP-binding protein; Provisional; Region: araG; PRK11288 693444005565 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 693444005566 Walker A/P-loop; other site 693444005567 ATP binding site [chemical binding]; other site 693444005568 Q-loop/lid; other site 693444005569 ABC transporter signature motif; other site 693444005570 Walker B; other site 693444005571 D-loop; other site 693444005572 H-loop/switch region; other site 693444005573 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 693444005574 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 693444005575 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 693444005576 TM-ABC transporter signature motif; other site 693444005577 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 693444005578 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 693444005579 active site 693444005580 motif I; other site 693444005581 motif II; other site 693444005582 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 693444005583 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 693444005584 active site 693444005585 homotetramer interface [polypeptide binding]; other site 693444005586 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 693444005587 Ligand Binding Site [chemical binding]; other site 693444005588 transcriptional activator FlhD; Provisional; Region: PRK02909 693444005589 transcriptional activator FlhC; Provisional; Region: PRK12722 693444005590 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 693444005591 flagellar motor protein MotA; Validated; Region: PRK09110 693444005592 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 693444005593 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 693444005594 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 693444005595 ligand binding site [chemical binding]; other site 693444005596 chemotaxis protein CheA; Provisional; Region: PRK10547 693444005597 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 693444005598 putative binding surface; other site 693444005599 active site 693444005600 CheY binding; Region: CheY-binding; pfam09078 693444005601 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 693444005602 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693444005603 ATP binding site [chemical binding]; other site 693444005604 Mg2+ binding site [ion binding]; other site 693444005605 G-X-G motif; other site 693444005606 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 693444005607 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 693444005608 putative CheA interaction surface; other site 693444005609 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 693444005610 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 693444005611 methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048 693444005612 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 693444005613 dimer interface [polypeptide binding]; other site 693444005614 ligand binding site [chemical binding]; other site 693444005615 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 693444005616 dimerization interface [polypeptide binding]; other site 693444005617 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 693444005618 dimer interface [polypeptide binding]; other site 693444005619 putative CheW interface [polypeptide binding]; other site 693444005620 methyl-accepting protein IV; Provisional; Region: PRK09793 693444005621 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 693444005622 dimer interface [polypeptide binding]; other site 693444005623 ligand binding site [chemical binding]; other site 693444005624 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 693444005625 dimerization interface [polypeptide binding]; other site 693444005626 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 693444005627 dimer interface [polypeptide binding]; other site 693444005628 putative CheW interface [polypeptide binding]; other site 693444005629 chemotaxis methyltransferase CheR; Provisional; Region: PRK10611 693444005630 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 693444005631 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693444005632 S-adenosylmethionine binding site [chemical binding]; other site 693444005633 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 693444005634 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693444005635 active site 693444005636 phosphorylation site [posttranslational modification] 693444005637 intermolecular recognition site; other site 693444005638 dimerization interface [polypeptide binding]; other site 693444005639 CheB methylesterase; Region: CheB_methylest; pfam01339 693444005640 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 693444005641 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693444005642 active site 693444005643 phosphorylation site [posttranslational modification] 693444005644 intermolecular recognition site; other site 693444005645 dimerization interface [polypeptide binding]; other site 693444005646 chemotaxis regulator CheZ; Provisional; Region: PRK11166 693444005647 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 693444005648 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 693444005649 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 693444005650 FHIPEP family; Region: FHIPEP; pfam00771 693444005651 Flagellar protein FlhE; Region: FlhE; pfam06366 693444005652 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 693444005653 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693444005654 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 693444005655 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 693444005656 arginyl-tRNA synthetase; Region: argS; TIGR00456 693444005657 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 693444005658 active site 693444005659 HIGH motif; other site 693444005660 KMSK motif region; other site 693444005661 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 693444005662 tRNA binding surface [nucleotide binding]; other site 693444005663 anticodon binding site; other site 693444005664 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_4; cd07268 693444005665 putative metal binding site [ion binding]; other site 693444005666 copper homeostasis protein CutC; Provisional; Region: PRK11572 693444005667 Protein of unknown function (DUF2384); Region: DUF2384; cl17718 693444005668 RES domain; Region: RES; smart00953 693444005669 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693444005670 S-adenosylmethionine binding site [chemical binding]; other site 693444005671 Methyltransferase domain; Region: Methyltransf_31; pfam13847 693444005672 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693444005673 S-adenosylmethionine binding site [chemical binding]; other site 693444005674 Uncharacterized relative of glutathione S-transferase, MAPEG superfamily [General function prediction only]; Region: COG3788 693444005675 hypothetical protein; Provisional; Region: PRK10302 693444005676 Isochorismatase family; Region: Isochorismatase; pfam00857 693444005677 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 693444005678 catalytic triad [active] 693444005679 conserved cis-peptide bond; other site 693444005680 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 693444005681 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 693444005682 dimer interface [polypeptide binding]; other site 693444005683 anticodon binding site; other site 693444005684 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 693444005685 homodimer interface [polypeptide binding]; other site 693444005686 motif 1; other site 693444005687 active site 693444005688 motif 2; other site 693444005689 GAD domain; Region: GAD; pfam02938 693444005690 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 693444005691 active site 693444005692 motif 3; other site 693444005693 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 693444005694 nudix motif; other site 693444005695 hypothetical protein; Validated; Region: PRK00110 693444005696 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 693444005697 active site 693444005698 putative DNA-binding cleft [nucleotide binding]; other site 693444005699 dimer interface [polypeptide binding]; other site 693444005700 ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226 693444005701 hypothetical protein; Provisional; Region: PRK11470 693444005702 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 693444005703 RuvA N terminal domain; Region: RuvA_N; pfam01330 693444005704 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 693444005705 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 693444005706 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693444005707 Walker A motif; other site 693444005708 ATP binding site [chemical binding]; other site 693444005709 Walker B motif; other site 693444005710 arginine finger; other site 693444005711 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 693444005712 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 693444005713 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 693444005714 ABC-ATPase subunit interface; other site 693444005715 dimer interface [polypeptide binding]; other site 693444005716 putative PBP binding regions; other site 693444005717 high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544 693444005718 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 693444005719 high-affinity zinc transporter periplasmic component; Reviewed; Region: znuA; PRK09545 693444005720 Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019 693444005721 metal binding site [ion binding]; metal-binding site 693444005722 putative peptidase; Provisional; Region: PRK11649 693444005723 Opacity-associated protein A N-terminal motif; Region: OapA_N; pfam08525 693444005724 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 693444005725 Peptidase family M23; Region: Peptidase_M23; pfam01551 693444005726 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 693444005727 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 693444005728 putative acyl-acceptor binding pocket; other site 693444005729 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 693444005730 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 693444005731 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 693444005732 Melibiase; Region: Melibiase; pfam02065 693444005733 pyruvate kinase; Provisional; Region: PRK05826 693444005734 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 693444005735 domain interfaces; other site 693444005736 active site 693444005737 DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302 693444005738 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 693444005739 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 693444005740 putative active site [active] 693444005741 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 693444005742 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 693444005743 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 693444005744 phosphogluconate dehydratase; Validated; Region: PRK09054 693444005745 6-phosphogluconate dehydratase; Region: edd; TIGR01196 693444005746 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 693444005747 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 693444005748 active site 693444005749 intersubunit interface [polypeptide binding]; other site 693444005750 catalytic residue [active] 693444005751 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 693444005752 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 693444005753 ATP-grasp domain; Region: ATP-grasp; pfam02222 693444005754 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2979 693444005755 tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178 693444005756 putative metal binding site [ion binding]; other site 693444005757 protease 2; Provisional; Region: PRK10115 693444005758 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 693444005759 exodeoxyribonuclease X; Provisional; Region: PRK07983 693444005760 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 693444005761 active site 693444005762 catalytic site [active] 693444005763 substrate binding site [chemical binding]; other site 693444005764 Predicted amidohydrolase [General function prediction only]; Region: COG0388 693444005765 Carbon-nitrogen hydrolase; Region: CN_hydrolase; pfam00795 693444005766 DNA polymerase III subunit theta; Reviewed; Region: PRK10969 693444005767 CopC domain; Region: CopC; cl01012 693444005768 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 693444005769 Protein of unknown function (DUF2511); Region: DUF2511; pfam10709 693444005770 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 693444005771 trimer interface [polypeptide binding]; other site 693444005772 active site 693444005773 substrate binding site [chemical binding]; other site 693444005774 CoA binding site [chemical binding]; other site 693444005775 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 693444005776 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 693444005777 active site 693444005778 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 693444005779 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 693444005780 putative acyl-acceptor binding pocket; other site 693444005781 Protein of unknown function (DUF1482); Region: DUF1482; pfam07358 693444005782 Protein of unknown function (DUF1480); Region: DUF1480; pfam07351 693444005783 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 693444005784 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693444005785 S-adenosylmethionine binding site [chemical binding]; other site 693444005786 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 693444005787 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 693444005788 mce related protein; Region: MCE; pfam02470 693444005789 mce related protein; Region: MCE; pfam02470 693444005790 mce related protein; Region: MCE; pfam02470 693444005791 mce related protein; Region: MCE; pfam02470 693444005792 mce related protein; Region: MCE; pfam02470 693444005793 integral membrane protein, PqiA family; Region: pqiA_fam; TIGR00155 693444005794 Paraquat-inducible protein A; Region: PqiA; pfam04403 693444005795 Paraquat-inducible protein A; Region: PqiA; pfam04403 693444005796 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 693444005797 GAF domain; Region: GAF_2; pfam13185 693444005798 ProP expression regulator; Provisional; Region: PRK04950 693444005799 ProQ/FINO family; Region: ProQ; pfam04352 693444005800 carboxy-terminal protease; Provisional; Region: PRK11186 693444005801 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 693444005802 protein binding site [polypeptide binding]; other site 693444005803 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 693444005804 Catalytic dyad [active] 693444005805 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 693444005806 heat shock protein HtpX; Provisional; Region: PRK05457 693444005807 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 693444005808 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693444005809 putative substrate translocation pore; other site 693444005810 DNA-binding transcriptional regulator KdgR; Provisional; Region: PRK15090 693444005811 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 693444005812 dimerization interface [polypeptide binding]; other site 693444005813 putative Zn2+ binding site [ion binding]; other site 693444005814 putative DNA binding site [nucleotide binding]; other site 693444005815 Bacterial transcriptional regulator; Region: IclR; pfam01614 693444005816 YobH-like protein; Region: YobH; pfam13996 693444005817 PhoPQ regulatory protein; Provisional; Region: PRK10299 693444005818 YebO-like protein; Region: YebO; pfam13974 693444005819 Protein of unknown function (DUF2627); Region: DUF2527; pfam10736 693444005820 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 693444005821 DNA-binding site [nucleotide binding]; DNA binding site 693444005822 RNA-binding motif; other site 693444005823 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 693444005824 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 693444005825 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 693444005826 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 693444005827 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693444005828 S-adenosylmethionine binding site [chemical binding]; other site 693444005829 hypothetical protein; Provisional; Region: PRK11469 693444005830 Domain of unknown function DUF; Region: DUF204; pfam02659 693444005831 Domain of unknown function DUF; Region: DUF204; pfam02659 693444005832 yybP-ykoY leader; D782_1823; IMG reference gene:2507516519 693444005833 hypothetical protein; Provisional; Region: PRK02913 693444005834 PTS system mannose-specific transporter subunit IID; Provisional; Region: PRK11103 693444005835 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 693444005836 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 693444005837 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 693444005838 active pocket/dimerization site; other site 693444005839 active site 693444005840 phosphorylation site [posttranslational modification] 693444005841 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 693444005842 active site 693444005843 phosphorylation site [posttranslational modification] 693444005844 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 693444005845 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 693444005846 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 693444005847 Transporter associated domain; Region: CorC_HlyC; smart01091 693444005848 phage resistance protein; Provisional; Region: PRK10551 693444005849 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 693444005850 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 693444005851 L-serine deaminase; Provisional; Region: PRK15023 693444005852 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 693444005853 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 693444005854 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 693444005855 putative active site [active] 693444005856 putative CoA binding site [chemical binding]; other site 693444005857 nudix motif; other site 693444005858 metal binding site [ion binding]; metal-binding site 693444005859 aminodeoxychorismate synthase subunit I; Provisional; Region: pabB; PRK15465 693444005860 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 693444005861 chorismate binding enzyme; Region: Chorismate_bind; cl10555 693444005862 hypothetical protein; Provisional; Region: PRK05114 693444005863 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 693444005864 homotrimer interaction site [polypeptide binding]; other site 693444005865 putative active site [active] 693444005866 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 693444005867 DEAD/DEAH box helicase; Region: DEAD; pfam00270 693444005868 DEAD_2; Region: DEAD_2; pfam06733 693444005869 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 693444005870 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 693444005871 Glycoprotease family; Region: Peptidase_M22; pfam00814 693444005872 Starvation-inducible outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: Slp; COG3065 693444005873 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974 693444005874 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 693444005875 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 693444005876 acyl-activating enzyme (AAE) consensus motif; other site 693444005877 putative AMP binding site [chemical binding]; other site 693444005878 putative active site [active] 693444005879 putative CoA binding site [chemical binding]; other site 693444005880 ribonuclease D; Provisional; Region: PRK10829 693444005881 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 693444005882 catalytic site [active] 693444005883 putative active site [active] 693444005884 putative substrate binding site [chemical binding]; other site 693444005885 Helicase and RNase D C-terminal; Region: HRDC; smart00341 693444005886 cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296 693444005887 cell division inhibitor MinD; Provisional; Region: PRK10818 693444005888 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 693444005889 Switch I; other site 693444005890 Switch II; other site 693444005891 septum formation inhibitor; Reviewed; Region: minC; PRK03511 693444005892 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 693444005893 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 693444005894 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3100 693444005895 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 693444005896 hypothetical protein; Provisional; Region: PRK10691 693444005897 hypothetical protein; Provisional; Region: PRK05170 693444005898 disulfide bond formation protein B; Provisional; Region: PRK01749 693444005899 sodium/proton antiporter; Reviewed; Region: nhaB; PRK09547 693444005900 fatty acid metabolism regulator; Provisional; Region: PRK04984 693444005901 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 693444005902 DNA-binding site [nucleotide binding]; DNA binding site 693444005903 FadR C-terminal domain; Region: FadR_C; pfam07840 693444005904 SpoVR family protein; Provisional; Region: PRK11767 693444005905 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 693444005906 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 693444005907 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 693444005908 hydroxyglutarate oxidase; Provisional; Region: PRK11728 693444005909 alanine racemase; Reviewed; Region: dadX; PRK03646 693444005910 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 693444005911 active site 693444005912 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 693444005913 substrate binding site [chemical binding]; other site 693444005914 catalytic residues [active] 693444005915 dimer interface [polypeptide binding]; other site 693444005916 NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain [Inorganic ion transport and metabolism]; Region: COG3263 693444005917 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 693444005918 TrkA-C domain; Region: TrkA_C; pfam02080 693444005919 Transporter associated domain; Region: CorC_HlyC; smart01091 693444005920 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 693444005921 dimer interface [polypeptide binding]; other site 693444005922 catalytic triad [active] 693444005923 lytic murein endotransglycosylase E; Provisional; Region: emtA; PRK15470 693444005924 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 693444005925 N-acetyl-D-glucosamine binding site [chemical binding]; other site 693444005926 catalytic residue [active] 693444005927 Flagellar regulator YcgR; Region: YcgR; pfam07317 693444005928 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 693444005929 PilZ domain; Region: PilZ; pfam07238 693444005930 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 693444005931 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 693444005932 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 693444005933 N-terminal plug; other site 693444005934 ligand-binding site [chemical binding]; other site 693444005935 Neutral trehalase [Carbohydrate transport and metabolism]; Region: TreA; COG1626 693444005936 trehalase; Provisional; Region: treA; PRK13271 693444005937 allophanate hydrolase; Provisional; Region: PRK08186 693444005938 Amidase; Region: Amidase; cl11426 693444005939 urea carboxylase; Region: urea_carbox; TIGR02712 693444005940 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 693444005941 ATP-grasp domain; Region: ATP-grasp_4; cl17255 693444005942 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 693444005943 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 693444005944 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 693444005945 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 693444005946 carboxyltransferase (CT) interaction site; other site 693444005947 biotinylation site [posttranslational modification]; other site 693444005948 Transcriptional regulators [Transcription]; Region: GntR; COG1802 693444005949 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 693444005950 DNA-binding site [nucleotide binding]; DNA binding site 693444005951 FCD domain; Region: FCD; pfam07729 693444005952 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 693444005953 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 693444005954 putative ligand binding site [chemical binding]; other site 693444005955 HEAT repeats; Region: HEAT_2; pfam13646 693444005956 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 693444005957 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 693444005958 TM-ABC transporter signature motif; other site 693444005959 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 693444005960 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 693444005961 TM-ABC transporter signature motif; other site 693444005962 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 693444005963 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 693444005964 Walker A/P-loop; other site 693444005965 ATP binding site [chemical binding]; other site 693444005966 Q-loop/lid; other site 693444005967 ABC transporter signature motif; other site 693444005968 Walker B; other site 693444005969 D-loop; other site 693444005970 H-loop/switch region; other site 693444005971 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 693444005972 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 693444005973 Walker A/P-loop; other site 693444005974 ATP binding site [chemical binding]; other site 693444005975 Q-loop/lid; other site 693444005976 ABC transporter signature motif; other site 693444005977 Walker B; other site 693444005978 D-loop; other site 693444005979 H-loop/switch region; other site 693444005980 propionate catabolism operon regulatory protein PrpR; Provisional; Region: PRK15424 693444005981 Propionate catabolism activator; Region: PrpR_N; pfam06506 693444005982 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693444005983 Walker A motif; other site 693444005984 ATP binding site [chemical binding]; other site 693444005985 Walker B motif; other site 693444005986 arginine finger; other site 693444005987 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 693444005988 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 693444005989 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 693444005990 tetramer interface [polypeptide binding]; other site 693444005991 active site 693444005992 Mg2+/Mn2+ binding site [ion binding]; other site 693444005993 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 693444005994 methylcitrate synthase; Provisional; Region: PRK12351 693444005995 oxalacetate binding site [chemical binding]; other site 693444005996 citrylCoA binding site [chemical binding]; other site 693444005997 coenzyme A binding site [chemical binding]; other site 693444005998 catalytic triad [active] 693444005999 2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425 693444006000 2-methylcitrate dehydratase; Region: prpD; TIGR02330 693444006001 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 693444006002 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 693444006003 acyl-activating enzyme (AAE) consensus motif; other site 693444006004 AMP binding site [chemical binding]; other site 693444006005 active site 693444006006 CoA binding site [chemical binding]; other site 693444006007 GTP-binding protein YchF; Reviewed; Region: PRK09601 693444006008 YchF GTPase; Region: YchF; cd01900 693444006009 G1 box; other site 693444006010 GTP/Mg2+ binding site [chemical binding]; other site 693444006011 Switch I region; other site 693444006012 G2 box; other site 693444006013 Switch II region; other site 693444006014 G3 box; other site 693444006015 G4 box; other site 693444006016 G5 box; other site 693444006017 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 693444006018 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 693444006019 putative active site [active] 693444006020 catalytic residue [active] 693444006021 hypothetical protein; Provisional; Region: PRK10692 693444006022 putative transporter; Provisional; Region: PRK11660 693444006023 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 693444006024 Sulfate transporter family; Region: Sulfate_transp; pfam00916 693444006025 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 693444006026 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 693444006027 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 693444006028 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 693444006029 active site 693444006030 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 693444006031 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 693444006032 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 693444006033 outer membrane lipoprotein LolB; Provisional; Region: lolB; PRK00022 693444006034 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 693444006035 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 693444006036 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 693444006037 tRNA; other site 693444006038 putative tRNA binding site [nucleotide binding]; other site 693444006039 putative NADP binding site [chemical binding]; other site 693444006040 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 693444006041 peptide chain release factor 1; Validated; Region: prfA; PRK00591 693444006042 This domain is found in peptide chain release factors; Region: PCRF; smart00937 693444006043 RF-1 domain; Region: RF-1; pfam00472 693444006044 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 693444006045 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693444006046 Invasion gene expression up-regulator, SirB; Region: SirB; cl01184 693444006047 hypothetical protein; Provisional; Region: PRK10941 693444006048 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 693444006049 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 693444006050 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 693444006051 calcium/sodium:proton antiporter; Provisional; Region: PRK10599 693444006052 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 693444006053 cation transport regulator; Reviewed; Region: chaB; PRK09582 693444006054 Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703 693444006055 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 693444006056 putative active site pocket [active] 693444006057 dimerization interface [polypeptide binding]; other site 693444006058 putative catalytic residue [active] 693444006059 Domain of unknown function (DUF1883); Region: DUF1883; pfam08980 693444006060 Uncharacterized conserved protein involved in intracellular sulfur reduction [Inorganic ion transport and metabolism]; Region: DsrE; COG1553 693444006061 Nitrate and nitrite sensing; Region: NIT; pfam08376 693444006062 ANTAR domain; Region: ANTAR; pfam03861 693444006063 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 693444006064 NMT1-like family; Region: NMT1_2; pfam13379 693444006065 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 693444006066 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693444006067 dimer interface [polypeptide binding]; other site 693444006068 conserved gate region; other site 693444006069 putative PBP binding loops; other site 693444006070 ABC-ATPase subunit interface; other site 693444006071 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 693444006072 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 693444006073 Walker A/P-loop; other site 693444006074 ATP binding site [chemical binding]; other site 693444006075 Q-loop/lid; other site 693444006076 ABC transporter signature motif; other site 693444006077 Walker B; other site 693444006078 D-loop; other site 693444006079 H-loop/switch region; other site 693444006080 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 693444006081 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 693444006082 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 693444006083 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 693444006084 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 693444006085 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 693444006086 [4Fe-4S] binding site [ion binding]; other site 693444006087 molybdopterin cofactor binding site; other site 693444006088 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 693444006089 molybdopterin cofactor binding site; other site 693444006090 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 693444006091 putative invasin; Provisional; Region: PRK10177 693444006092 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 693444006093 transcriptional regulator NarL; Provisional; Region: PRK10651 693444006094 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693444006095 active site 693444006096 phosphorylation site [posttranslational modification] 693444006097 intermolecular recognition site; other site 693444006098 dimerization interface [polypeptide binding]; other site 693444006099 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 693444006100 DNA binding residues [nucleotide binding] 693444006101 dimerization interface [polypeptide binding]; other site 693444006102 nitrate/nitrite sensor protein NarX; Provisional; Region: PRK10600 693444006103 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 693444006104 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 693444006105 dimerization interface [polypeptide binding]; other site 693444006106 Histidine kinase; Region: HisKA_3; pfam07730 693444006107 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693444006108 ATP binding site [chemical binding]; other site 693444006109 Mg2+ binding site [ion binding]; other site 693444006110 G-X-G motif; other site 693444006111 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 693444006112 respiratory nitrate reductase, alpha subunit; Region: narG; TIGR01580 693444006113 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 693444006114 [4Fe-4S] binding site [ion binding]; other site 693444006115 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 693444006116 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 693444006117 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 693444006118 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 693444006119 molybdopterin cofactor binding site; other site 693444006120 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 693444006121 4Fe-4S binding domain; Region: Fer4; cl02805 693444006122 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 693444006123 respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351 693444006124 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 693444006125 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 693444006126 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 693444006127 putative active site [active] 693444006128 putative substrate binding site [chemical binding]; other site 693444006129 putative cosubstrate binding site; other site 693444006130 catalytic site [active] 693444006131 SEC-C motif; Region: SEC-C; pfam02810 693444006132 hypothetical protein; Provisional; Region: PRK04233 693444006133 hypothetical protein; Provisional; Region: PRK10279 693444006134 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 693444006135 active site 693444006136 nucleophile elbow; other site 693444006137 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693444006138 active site 693444006139 response regulator of RpoS; Provisional; Region: PRK10693 693444006140 phosphorylation site [posttranslational modification] 693444006141 intermolecular recognition site; other site 693444006142 dimerization interface [polypeptide binding]; other site 693444006143 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 693444006144 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 693444006145 active site 693444006146 tetramer interface; other site 693444006147 global DNA-binding transcriptional dual regulator H-NS; Provisional; Region: PRK10947 693444006148 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 693444006149 thymidine kinase; Provisional; Region: PRK04296 693444006150 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 693444006151 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 693444006152 putative catalytic cysteine [active] 693444006153 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 693444006154 putative active site [active] 693444006155 metal binding site [ion binding]; metal-binding site 693444006156 hypothetical protein; Provisional; Region: PRK11111 693444006157 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 693444006158 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 693444006159 peptide binding site [polypeptide binding]; other site 693444006160 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 693444006161 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693444006162 dimer interface [polypeptide binding]; other site 693444006163 conserved gate region; other site 693444006164 putative PBP binding loops; other site 693444006165 ABC-ATPase subunit interface; other site 693444006166 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 693444006167 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 693444006168 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693444006169 dimer interface [polypeptide binding]; other site 693444006170 conserved gate region; other site 693444006171 ABC-ATPase subunit interface; other site 693444006172 oligopeptide transporter ATP-binding component; Provisional; Region: oppD; PRK09473 693444006173 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 693444006174 Walker A/P-loop; other site 693444006175 ATP binding site [chemical binding]; other site 693444006176 Q-loop/lid; other site 693444006177 ABC transporter signature motif; other site 693444006178 Walker B; other site 693444006179 D-loop; other site 693444006180 H-loop/switch region; other site 693444006181 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 693444006182 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 693444006183 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 693444006184 Walker A/P-loop; other site 693444006185 ATP binding site [chemical binding]; other site 693444006186 Q-loop/lid; other site 693444006187 ABC transporter signature motif; other site 693444006188 Walker B; other site 693444006189 D-loop; other site 693444006190 H-loop/switch region; other site 693444006191 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 693444006192 Ion transport protein; Region: Ion_trans; pfam00520 693444006193 Ion channel; Region: Ion_trans_2; pfam07885 693444006194 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 693444006195 dsDNA-mimic protein; Reviewed; Region: PRK05094 693444006196 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 693444006197 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 693444006198 Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152 693444006199 putative active site [active] 693444006200 catalytic site [active] 693444006201 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158 693444006202 putative active site [active] 693444006203 catalytic site [active] 693444006204 YciI-like protein; Reviewed; Region: PRK11370 693444006205 transport protein TonB; Provisional; Region: PRK10819 693444006206 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 693444006207 Phosphotransferase enzyme family; Region: APH; pfam01636 693444006208 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 693444006209 active site 693444006210 ATP binding site [chemical binding]; other site 693444006211 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 693444006212 active site 693444006213 ATP binding site [chemical binding]; other site 693444006214 Protein of unknown function (DUF2622); Region: DUF2622; pfam11080 693444006215 6-phosphofructokinase 2; Provisional; Region: PRK10294 693444006216 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 693444006217 putative substrate binding site [chemical binding]; other site 693444006218 putative ATP binding site [chemical binding]; other site 693444006219 Putative salt-induced outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG3137 693444006220 Predicted periplasmic/secreted protein [Function unknown]; Region: COG3477 693444006221 Predicted membrane protein [Function unknown]; Region: COG2323 693444006222 Protein of unknown function (DUF3290); Region: DUF3290; pfam11694 693444006223 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 693444006224 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 693444006225 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 693444006226 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 693444006227 active site 693444006228 dimer interface [polypeptide binding]; other site 693444006229 motif 1; other site 693444006230 motif 2; other site 693444006231 motif 3; other site 693444006232 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 693444006233 anticodon binding site; other site 693444006234 Long range pseudoknot; D782_1940; IMG reference gene:2507516636 693444006235 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 693444006236 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 693444006237 23S rRNA binding site [nucleotide binding]; other site 693444006238 L21 binding site [polypeptide binding]; other site 693444006239 L13 binding site [polypeptide binding]; other site 693444006240 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 693444006241 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 693444006242 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 693444006243 dimer interface [polypeptide binding]; other site 693444006244 motif 1; other site 693444006245 active site 693444006246 motif 2; other site 693444006247 motif 3; other site 693444006248 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 693444006249 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 693444006250 putative tRNA-binding site [nucleotide binding]; other site 693444006251 B3/4 domain; Region: B3_4; pfam03483 693444006252 tRNA synthetase B5 domain; Region: B5; smart00874 693444006253 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 693444006254 dimer interface [polypeptide binding]; other site 693444006255 motif 1; other site 693444006256 motif 3; other site 693444006257 motif 2; other site 693444006258 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 693444006259 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 693444006260 IHF dimer interface [polypeptide binding]; other site 693444006261 IHF - DNA interface [nucleotide binding]; other site 693444006262 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 693444006263 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 693444006264 ABC-ATPase subunit interface; other site 693444006265 dimer interface [polypeptide binding]; other site 693444006266 putative PBP binding regions; other site 693444006267 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 693444006268 catalytic residues [active] 693444006269 dimer interface [polypeptide binding]; other site 693444006270 vitamin B12-transporter ATPase; Provisional; Region: PRK03695 693444006271 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 693444006272 Walker A/P-loop; other site 693444006273 ATP binding site [chemical binding]; other site 693444006274 Q-loop/lid; other site 693444006275 ABC transporter signature motif; other site 693444006276 Walker B; other site 693444006277 D-loop; other site 693444006278 H-loop/switch region; other site 693444006279 NlpC/P60 family; Region: NLPC_P60; pfam00877 693444006280 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290 693444006281 Uncharacterized conserved protein [Function unknown]; Region: COG0397 693444006282 hypothetical protein; Validated; Region: PRK00029 693444006283 Hemin uptake protein hemP; Region: hemP; cl10043 693444006284 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12756 693444006285 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 693444006286 PEP synthetase regulatory protein; Provisional; Region: PRK05339 693444006287 phosphoenolpyruvate synthase; Validated; Region: PRK06464 693444006288 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 693444006289 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 693444006290 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 693444006291 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 693444006292 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 693444006293 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 693444006294 putative inner membrane protein; Provisional; Region: PRK10983 693444006295 Domain of unknown function DUF20; Region: UPF0118; pfam01594 693444006296 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 693444006297 FAD binding domain; Region: FAD_binding_4; pfam01565 693444006298 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 693444006299 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 693444006300 CoenzymeA binding site [chemical binding]; other site 693444006301 subunit interaction site [polypeptide binding]; other site 693444006302 PHB binding site; other site 693444006303 Protein of unknown function (DUF3828); Region: DUF3828; pfam12883 693444006304 iron-sulfur cluster assembly scaffold protein; Provisional; Region: sufA; PRK09504 693444006305 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 693444006306 putative ABC transporter; Region: ycf24; CHL00085 693444006307 cysteine desulfurase ATPase component; Reviewed; Region: sufC; PRK09580 693444006308 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 693444006309 Walker A/P-loop; other site 693444006310 ATP binding site [chemical binding]; other site 693444006311 Q-loop/lid; other site 693444006312 ABC transporter signature motif; other site 693444006313 Walker B; other site 693444006314 D-loop; other site 693444006315 H-loop/switch region; other site 693444006316 cysteine desulfurase activator complex subunit SufD; Provisional; Region: PRK10948 693444006317 FeS assembly protein SufD; Region: sufD; TIGR01981 693444006318 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 693444006319 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 693444006320 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 693444006321 catalytic residue [active] 693444006322 cysteine desufuration protein SufE; Provisional; Region: PRK09296 693444006323 L,D-transpeptidase; Provisional; Region: PRK10190 693444006324 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 693444006325 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 693444006326 murein lipoprotein; Provisional; Region: PRK15396 693444006327 pyruvate kinase; Provisional; Region: PRK09206 693444006328 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 693444006329 domain interfaces; other site 693444006330 active site 693444006331 hypothetical protein; Provisional; Region: PRK10292 693444006332 HTH-type transcriptional regulator RutR; Provisional; Region: PRK15008 693444006333 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 693444006334 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 693444006335 4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185 693444006336 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 693444006337 dimer interface [polypeptide binding]; other site 693444006338 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 693444006339 active site 693444006340 Fe binding site [ion binding]; other site 693444006341 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693444006342 D-galactonate transporter; Region: 2A0114; TIGR00893 693444006343 putative substrate translocation pore; other site 693444006344 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 693444006345 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 693444006346 shikimate binding site; other site 693444006347 NAD(P) binding site [chemical binding]; other site 693444006348 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 693444006349 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 693444006350 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 693444006351 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 693444006352 Walker A/P-loop; other site 693444006353 ATP binding site [chemical binding]; other site 693444006354 Q-loop/lid; other site 693444006355 ABC transporter signature motif; other site 693444006356 Walker B; other site 693444006357 D-loop; other site 693444006358 H-loop/switch region; other site 693444006359 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 693444006360 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 693444006361 ABC-ATPase subunit interface; other site 693444006362 dimer interface [polypeptide binding]; other site 693444006363 putative PBP binding regions; other site 693444006364 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 693444006365 Periplasmic binding protein TroA_e. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_e; cd01142 693444006366 putative ligand binding residues [chemical binding]; other site 693444006367 DNA-binding transcriptional activator MhpR; Provisional; Region: PRK09834 693444006368 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 693444006369 Bacterial transcriptional regulator; Region: IclR; pfam01614 693444006370 3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183 693444006371 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 693444006372 Subunit B of the Class III Extradiol ring-cleavage dioxygenase, 2,3-dihydroxyphenylpropionate 1,2-dioxygenase (MhpB), which catalyzes the oxidization and subsequent ring-opening of 2,3-dihydroxyphenylpropionate; Region: MhpB_like; cd07365 693444006373 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 693444006374 putative active site [active] 693444006375 Fe(II) binding site [ion binding]; other site 693444006376 putative dimer interface [polypeptide binding]; other site 693444006377 putative tetramer interface [polypeptide binding]; other site 693444006378 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343 693444006379 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 693444006380 2-keto-4-pentenoate hydratase; Provisional; Region: mhpD; PRK11342 693444006381 acetaldehyde dehydrogenase; Validated; Region: PRK08300 693444006382 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 693444006383 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 693444006384 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 693444006385 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 693444006386 active site 693444006387 catalytic residues [active] 693444006388 metal binding site [ion binding]; metal-binding site 693444006389 DmpG-like communication domain; Region: DmpG_comm; pfam07836 693444006390 putative 3-hydroxyphenylpropionic transporter MhpT; Provisional; Region: PRK11551 693444006391 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693444006392 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 693444006393 nucleotide binding site/active site [active] 693444006394 HIT family signature motif; other site 693444006395 catalytic residue [active] 693444006396 Predicted periplasmic lipoprotein [General function prediction only]; Region: COG5633 693444006397 Putative periplasmic lipoprotein; Region: DUF1425; cd09030 693444006398 putative dimer interface [polypeptide binding]; other site 693444006399 Collagen-binding surface adhesin SpaP (antigen I/II family) [General function prediction only]; Region: FlgN; COG3417 693444006400 thiamine kinase; Region: ycfN_thiK; TIGR02721 693444006401 active site 693444006402 substrate binding site [chemical binding]; other site 693444006403 ATP binding site [chemical binding]; other site 693444006404 thiamine kinase; Provisional; Region: thiK; PRK10271 693444006405 beta-hexosaminidase; Provisional; Region: PRK05337 693444006406 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 693444006407 hypothetical protein; Provisional; Region: PRK04940 693444006408 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 693444006409 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 693444006410 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 693444006411 hypothetical protein; Provisional; Region: PRK11280 693444006412 PAAR motif; Region: PAAR_motif; pfam05488 693444006413 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 693444006414 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 693444006415 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 693444006416 L,D-transpeptidase; Provisional; Region: PRK10190 693444006417 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 693444006418 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 693444006419 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 693444006420 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 693444006421 N-terminal plug; other site 693444006422 ligand-binding site [chemical binding]; other site 693444006423 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 693444006424 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 693444006425 Walker A/P-loop; other site 693444006426 ATP binding site [chemical binding]; other site 693444006427 Q-loop/lid; other site 693444006428 ABC transporter signature motif; other site 693444006429 Walker B; other site 693444006430 D-loop; other site 693444006431 H-loop/switch region; other site 693444006432 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 693444006433 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 693444006434 ABC-ATPase subunit interface; other site 693444006435 dimer interface [polypeptide binding]; other site 693444006436 putative PBP binding regions; other site 693444006437 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 693444006438 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 693444006439 ABC-ATPase subunit interface; other site 693444006440 dimer interface [polypeptide binding]; other site 693444006441 putative PBP binding regions; other site 693444006442 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 693444006443 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 693444006444 siderophore binding site; other site 693444006445 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 693444006446 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 693444006447 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 693444006448 putative active site [active] 693444006449 Fimbrial protein; Region: Fimbrial; cl01416 693444006450 zinc/cadmium-binding protein; Provisional; Region: PRK10306 693444006451 multidrug efflux protein; Reviewed; Region: PRK01766 693444006452 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 693444006453 cation binding site [ion binding]; other site 693444006454 riboflavin synthase subunit alpha; Provisional; Region: PRK13020 693444006455 Lumazine binding domain; Region: Lum_binding; pfam00677 693444006456 Lumazine binding domain; Region: Lum_binding; pfam00677 693444006457 cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705 693444006458 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 693444006459 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693444006460 S-adenosylmethionine binding site [chemical binding]; other site 693444006461 putative transporter; Provisional; Region: PRK11043 693444006462 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693444006463 putative substrate translocation pore; other site 693444006464 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 693444006465 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693444006466 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 693444006467 dimerization interface [polypeptide binding]; other site 693444006468 DNA-binding transcriptional repressor PurR; Provisional; Region: PRK10703 693444006469 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 693444006470 DNA binding site [nucleotide binding] 693444006471 domain linker motif; other site 693444006472 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 693444006473 dimerization interface [polypeptide binding]; other site 693444006474 ligand binding site [chemical binding]; other site 693444006475 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 693444006476 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693444006477 putative substrate translocation pore; other site 693444006478 superoxide dismutase; Provisional; Region: PRK10543 693444006479 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 693444006480 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 693444006481 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 693444006482 NlpC/P60 family; Region: NLPC_P60; pfam00877 693444006483 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 693444006484 putative GSH binding site [chemical binding]; other site 693444006485 catalytic residues [active] 693444006486 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 693444006487 DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134 693444006488 dimer interface [polypeptide binding]; other site 693444006489 catalytic site [active] 693444006490 putative active site [active] 693444006491 putative substrate binding site [chemical binding]; other site 693444006492 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 693444006493 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 693444006494 dimer interface [polypeptide binding]; other site 693444006495 active site 693444006496 metal binding site [ion binding]; metal-binding site 693444006497 glutathione binding site [chemical binding]; other site 693444006498 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 693444006499 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 693444006500 FMN binding site [chemical binding]; other site 693444006501 active site 693444006502 substrate binding site [chemical binding]; other site 693444006503 catalytic residue [active] 693444006504 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 693444006505 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 693444006506 Predicted Fe-S protein [General function prediction only]; Region: COG3313 693444006507 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 693444006508 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 693444006509 active site 693444006510 catalytic tetrad [active] 693444006511 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 693444006512 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 693444006513 E-class dimer interface [polypeptide binding]; other site 693444006514 P-class dimer interface [polypeptide binding]; other site 693444006515 active site 693444006516 Cu2+ binding site [ion binding]; other site 693444006517 Zn2+ binding site [ion binding]; other site 693444006518 Fusaric acid resistance protein family; Region: FUSC; pfam04632 693444006519 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 693444006520 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 693444006521 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 693444006522 HlyD family secretion protein; Region: HlyD_3; pfam13437 693444006523 Protein of unknown function (DUF1656); Region: DUF1656; pfam07869 693444006524 transcriptional regulator SlyA; Provisional; Region: PRK03573 693444006525 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 693444006526 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 693444006527 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693444006528 metal binding site [ion binding]; metal-binding site 693444006529 active site 693444006530 I-site; other site 693444006531 Outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: SlyB; COG3133 693444006532 Uncharacterized protein family (UPF0075); Region: UPF0075; pfam03702 693444006533 lysozyme inhibitor; Provisional; Region: PRK11372 693444006534 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 693444006535 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 693444006536 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 693444006537 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 693444006538 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 693444006539 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 693444006540 active site 693444006541 HIGH motif; other site 693444006542 dimer interface [polypeptide binding]; other site 693444006543 KMSKS motif; other site 693444006544 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 693444006545 RNA binding surface [nucleotide binding]; other site 693444006546 glutathionine S-transferase; Provisional; Region: PRK10542 693444006547 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 693444006548 C-terminal domain interface [polypeptide binding]; other site 693444006549 GSH binding site (G-site) [chemical binding]; other site 693444006550 dimer interface [polypeptide binding]; other site 693444006551 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 693444006552 N-terminal domain interface [polypeptide binding]; other site 693444006553 dimer interface [polypeptide binding]; other site 693444006554 substrate binding pocket (H-site) [chemical binding]; other site 693444006555 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 693444006556 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693444006557 putative substrate translocation pore; other site 693444006558 POT family; Region: PTR2; pfam00854 693444006559 endonuclease III; Provisional; Region: PRK10702 693444006560 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 693444006561 minor groove reading motif; other site 693444006562 helix-hairpin-helix signature motif; other site 693444006563 substrate binding pocket [chemical binding]; other site 693444006564 active site 693444006565 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 693444006566 electron transport complex RsxE subunit; Provisional; Region: PRK12405 693444006567 electron transport complex protein RnfG; Validated; Region: PRK01908 693444006568 electron transport complex protein RnfD; Reviewed; Region: rnfD; PRK00816 693444006569 Predicted NADH:ubiquinone oxidoreductase, subunit RnfC [Energy production and conversion]; Region: RnfC; COG4656 693444006570 SLBB domain; Region: SLBB; pfam10531 693444006571 electron transport complex protein RnfB; Provisional; Region: PRK05113 693444006572 Putative Fe-S cluster; Region: FeS; cl17515 693444006573 4Fe-4S binding domain; Region: Fer4; pfam00037 693444006574 electron transport complex protein RsxA; Provisional; Region: PRK05151 693444006575 Protein of unknown function (DUF2569); Region: DUF2569; pfam10754 693444006576 oriC-binding nucleoid-associated protein; Provisional; Region: PRK10391 693444006577 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 693444006578 beta-galactosidase; Region: BGL; TIGR03356 693444006579 putative oxidoreductase; Provisional; Region: PRK11579 693444006580 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 693444006581 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 693444006582 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 693444006583 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 693444006584 active site 693444006585 purine riboside binding site [chemical binding]; other site 693444006586 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 693444006587 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 693444006588 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693444006589 homodimer interface [polypeptide binding]; other site 693444006590 catalytic residue [active] 693444006591 bifunctional PTS system maltose and glucose-specific transporter subunits IICB; Provisional; Region: PRK10110 693444006592 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 693444006593 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 693444006594 active site turn [active] 693444006595 phosphorylation site [posttranslational modification] 693444006596 DNA-binding transcriptional repressor MalI; Provisional; Region: PRK10014 693444006597 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 693444006598 DNA binding site [nucleotide binding] 693444006599 domain linker motif; other site 693444006600 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 693444006601 Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097 693444006602 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339 693444006603 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 693444006604 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 693444006605 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 693444006606 fumarate hydratase; Provisional; Region: PRK15389 693444006607 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 693444006608 Fumarase C-terminus; Region: Fumerase_C; pfam05683 693444006609 fumarate hydratase; Reviewed; Region: fumC; PRK00485 693444006610 Class II fumarases; Region: Fumarase_classII; cd01362 693444006611 active site 693444006612 tetramer interface [polypeptide binding]; other site 693444006613 DNA replication terminus site-binding protein; Provisional; Region: PRK02951 693444006614 sensor protein RstB; Provisional; Region: PRK10604 693444006615 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 693444006616 dimerization interface [polypeptide binding]; other site 693444006617 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 693444006618 dimer interface [polypeptide binding]; other site 693444006619 phosphorylation site [posttranslational modification] 693444006620 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693444006621 ATP binding site [chemical binding]; other site 693444006622 Mg2+ binding site [ion binding]; other site 693444006623 G-X-G motif; other site 693444006624 DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701 693444006625 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693444006626 active site 693444006627 phosphorylation site [posttranslational modification] 693444006628 intermolecular recognition site; other site 693444006629 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 693444006630 DNA binding site [nucleotide binding] 693444006631 GlpM protein; Region: GlpM; pfam06942 693444006632 dihydromonapterin reductase; Provisional; Region: PRK06483 693444006633 pteridine reductase (PR), classical (c) SDRs; Region: PR_SDR_c; cd05357 693444006634 NADP binding site [chemical binding]; other site 693444006635 substrate binding pocket [chemical binding]; other site 693444006636 active site 693444006637 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 693444006638 Spore germination protein; Region: Spore_permease; cl17796 693444006639 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 693444006640 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 693444006641 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 693444006642 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 693444006643 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 693444006644 ligand binding site [chemical binding]; other site 693444006645 homodimer interface [polypeptide binding]; other site 693444006646 NAD(P) binding site [chemical binding]; other site 693444006647 trimer interface B [polypeptide binding]; other site 693444006648 trimer interface A [polypeptide binding]; other site 693444006649 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 693444006650 pyridine nucleotide transhydrogenase; Provisional; Region: pntB; PRK09444 693444006651 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 693444006652 universal stress protein UspE; Provisional; Region: PRK11175 693444006653 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 693444006654 Ligand Binding Site [chemical binding]; other site 693444006655 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 693444006656 Ligand Binding Site [chemical binding]; other site 693444006657 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 693444006658 substrate binding site [chemical binding]; other site 693444006659 THF binding site; other site 693444006660 zinc-binding site [ion binding]; other site 693444006661 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 693444006662 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 693444006663 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 693444006664 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 693444006665 ligand binding site [chemical binding]; other site 693444006666 flexible hinge region; other site 693444006667 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 693444006668 putative switch regulator; other site 693444006669 non-specific DNA interactions [nucleotide binding]; other site 693444006670 DNA binding site [nucleotide binding] 693444006671 sequence specific DNA binding site [nucleotide binding]; other site 693444006672 putative cAMP binding site [chemical binding]; other site 693444006673 O-6-alkylguanine-DNA:cysteine-protein methyltransferase; Provisional; Region: PRK10286 693444006674 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 693444006675 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 693444006676 DNA binding site [nucleotide binding] 693444006677 active site 693444006678 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 693444006679 Smr domain; Region: Smr; pfam01713 693444006680 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 693444006681 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 693444006682 Bacterial transcriptional regulator; Region: IclR; pfam01614 693444006683 Coenzyme A transferase; Region: CoA_trans; cl17247 693444006684 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 693444006685 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 693444006686 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 693444006687 dimer interface [polypeptide binding]; other site 693444006688 active site 693444006689 3-carboxy-cis,cis-muconate cycloisomerase; Provisional; Region: PRK09053 693444006690 prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597 693444006691 tetramer interface [polypeptide binding]; other site 693444006692 active site 693444006693 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 693444006694 4-carboxymuconolactone decarboxylase; Region: decarb_PcaC; TIGR02425 693444006695 Protein of unknown function (DUF2566); Region: DUF2566; pfam10753 693444006696 Protein of unknown function (DUF2566); Region: DUF2566; pfam10753 693444006697 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 693444006698 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 693444006699 Salicylaldehyde dehydrogenase, DoxF-like; Region: ALDH_SaliADH; cd07105 693444006700 NAD(P) binding site [chemical binding]; other site 693444006701 catalytic residues [active] 693444006702 Uncharacterized protein conserved in bacteria, putative virulence factor [Function unknown]; Region: SrfC; COG4458 693444006703 Virulence factor SrfB; Region: SrfB; pfam07520 693444006704 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 693444006705 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 693444006706 peptide binding site [polypeptide binding]; other site 693444006707 Protein of unknown function (DUF2526); Region: DUF2526; pfam10735 693444006708 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 693444006709 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 693444006710 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 693444006711 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 693444006712 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 693444006713 non-specific DNA binding site [nucleotide binding]; other site 693444006714 salt bridge; other site 693444006715 sequence-specific DNA binding site [nucleotide binding]; other site 693444006716 Cupin domain; Region: Cupin_2; pfam07883 693444006717 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 693444006718 Prostaglandin dehydrogenases; Region: PGDH; cd05288 693444006719 NAD(P) binding site [chemical binding]; other site 693444006720 substrate binding site [chemical binding]; other site 693444006721 dimer interface [polypeptide binding]; other site 693444006722 colanic acid/biofilm transcriptional regulator; Provisional; Region: PRK11414 693444006723 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 693444006724 DNA-binding site [nucleotide binding]; DNA binding site 693444006725 FCD domain; Region: FCD; pfam07729 693444006726 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 693444006727 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 693444006728 N-terminal plug; other site 693444006729 ligand-binding site [chemical binding]; other site 693444006730 PQQ-like domain; Region: PQQ_2; pfam13360 693444006731 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 693444006732 L-asparagine permease; Provisional; Region: PRK15049 693444006733 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 693444006734 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 693444006735 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 693444006736 C-terminal domain interface [polypeptide binding]; other site 693444006737 GSH binding site (G-site) [chemical binding]; other site 693444006738 dimer interface [polypeptide binding]; other site 693444006739 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 693444006740 dimer interface [polypeptide binding]; other site 693444006741 N-terminal domain interface [polypeptide binding]; other site 693444006742 substrate binding pocket (H-site) [chemical binding]; other site 693444006743 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453 693444006744 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 693444006745 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 693444006746 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 693444006747 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 693444006748 N-hydroxyarylamine O-acetyltransferase; Provisional; Region: PRK15047 693444006749 Cupin; Region: Cupin_6; pfam12852 693444006750 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 693444006751 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 693444006752 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 693444006753 ribonucleoside transporter; Reviewed; Region: nepI; PRK10213 693444006754 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693444006755 putative substrate translocation pore; other site 693444006756 respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351 693444006757 nitrate reductase 2 subunit delta; Provisional; Region: PRK15054 693444006758 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 693444006759 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 693444006760 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 693444006761 [4Fe-4S] binding site [ion binding]; other site 693444006762 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 693444006763 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 693444006764 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 693444006765 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 693444006766 molybdopterin cofactor binding site; other site 693444006767 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 693444006768 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 693444006769 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 693444006770 Bacterial transcriptional regulator; Region: IclR; pfam01614 693444006771 Muconate Lactonizing Enzyme (MLE), an homooctameric enzyme, catalyses the conversion of cis,cis-muconate (CCM) to muconolactone (ML) in the catechol branch of the beta-ketoadipate pathway. This pathway is used in soil microbes to breakdown lignin-derived...; Region: MLE; cd03318 693444006772 muconate and chloromuconate cycloisomerases; Region: mucon_cyclo; TIGR02534 693444006773 octamer interface [polypeptide binding]; other site 693444006774 active site 693444006775 muconolactone delta-isomerase; Region: muco_delta; TIGR03221 693444006776 Catechol 1,2 dioxygenase (1,2-CTD) catalyzes an intradiol cleavage reaction of catechol to form cis,cis-muconate. 1,2-CTDs is homodimers with one catalytic non-heme ferric ion per monomer. They belong to the aromatic dioxygenase family, a family of...; Region: 1,2-CTD; cd03460 693444006777 catechol 1,2-dioxygenase, proteobacterial; Region: catechol_proteo; TIGR02439 693444006778 dimer interface [polypeptide binding]; other site 693444006779 active site 693444006780 benzoate 1,2-dioxygenase, large subunit; Region: benzo_1_2_benA; TIGR03229 693444006781 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 693444006782 iron-sulfur cluster [ion binding]; other site 693444006783 [2Fe-2S] cluster binding site [ion binding]; other site 693444006784 C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879 693444006785 putative alpha subunit interface [polypeptide binding]; other site 693444006786 putative active site [active] 693444006787 putative substrate binding site [chemical binding]; other site 693444006788 Fe binding site [ion binding]; other site 693444006789 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 693444006790 inter-subunit interface; other site 693444006791 anthranilate dioxygenase reductase; Provisional; Region: antC; PRK11872 693444006792 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 693444006793 catalytic loop [active] 693444006794 iron binding site [ion binding]; other site 693444006795 Benzoate dioxygenase reductase (BenDO) FAD/NAD binding domain. Oxygenases oxidize hydrocarbons using dioxygen as the oxidant. As a Class I bacterial dioxygenases, benzoate dioxygenase like proteins combine an [2Fe-2S] cluster containing N-terminal...; Region: BenDO_FAD_NAD; cd06209 693444006796 FAD binding pocket [chemical binding]; other site 693444006797 FAD binding motif [chemical binding]; other site 693444006798 phosphate binding motif [ion binding]; other site 693444006799 beta-alpha-beta structure motif; other site 693444006800 NAD binding pocket [chemical binding]; other site 693444006801 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase; Provisional; Region: benD; PRK12823 693444006802 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase (DHB DH)-like, classical (c) SDR; Region: DHB_DH-like_SDR_c; cd08937 693444006803 putative NAD(P) binding site [chemical binding]; other site 693444006804 active site 693444006805 aromatic amino acid exporter; Provisional; Region: PRK11689 693444006806 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 693444006807 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 693444006808 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 693444006809 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 693444006810 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 693444006811 molybdopterin cofactor binding site; other site 693444006812 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 693444006813 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 693444006814 formate dehydrogenase-N subunit gamma; Provisional; Region: PRK10179 693444006815 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 693444006816 CcdB protein; Region: CcdB; cl03380 693444006817 MFS transport protein AraJ; Provisional; Region: PRK10091 693444006818 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693444006819 putative substrate translocation pore; other site 693444006820 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 693444006821 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 693444006822 NAD binding site [chemical binding]; other site 693444006823 substrate binding site [chemical binding]; other site 693444006824 catalytic Zn binding site [ion binding]; other site 693444006825 tetramer interface [polypeptide binding]; other site 693444006826 structural Zn binding site [ion binding]; other site 693444006827 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 693444006828 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 693444006829 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 693444006830 malate dehydrogenase; Provisional; Region: PRK13529 693444006831 Malic enzyme, N-terminal domain; Region: malic; pfam00390 693444006832 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 693444006833 NAD(P) binding site [chemical binding]; other site 693444006834 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 693444006835 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 693444006836 putative NAD(P) binding site [chemical binding]; other site 693444006837 putative substrate binding site [chemical binding]; other site 693444006838 catalytic Zn binding site [ion binding]; other site 693444006839 structural Zn binding site [ion binding]; other site 693444006840 dimer interface [polypeptide binding]; other site 693444006841 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 693444006842 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 693444006843 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 693444006844 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 693444006845 Secretory lipase; Region: LIP; pfam03583 693444006846 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 693444006847 Protein of unknown function (DUF2545); Region: DUF2545; pfam10810 693444006848 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 693444006849 heme-binding site [chemical binding]; other site 693444006850 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 693444006851 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693444006852 metal binding site [ion binding]; metal-binding site 693444006853 active site 693444006854 I-site; other site 693444006855 nucleotide excision repair endonuclease; Provisional; Region: PRK10545 693444006856 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 693444006857 GIY-YIG motif/motif A; other site 693444006858 active site 693444006859 catalytic site [active] 693444006860 putative DNA binding site [nucleotide binding]; other site 693444006861 metal binding site [ion binding]; metal-binding site 693444006862 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 693444006863 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 693444006864 DNA binding residues [nucleotide binding] 693444006865 Biofilm development protein YmgB/AriR; Region: YmgB; pfam10798 693444006866 Biofilm development protein YmgB/AriR; Region: YmgB; pfam10798 693444006867 Sensors of blue-light using FAD; Region: BLUF; pfam04940 693444006868 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 693444006869 transcriptional regulator MirA; Provisional; Region: PRK15043 693444006870 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 693444006871 DNA binding residues [nucleotide binding] 693444006872 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 693444006873 Ligand binding site; other site 693444006874 metal-binding site 693444006875 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 693444006876 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 693444006877 XdhC Rossmann domain; Region: XdhC_C; pfam13478 693444006878 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 693444006879 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; pfam01315 693444006880 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 693444006881 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 693444006882 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 693444006883 aldehyde oxidoreductase 2Fe-2S subunit; Provisional; Region: PRK11433 693444006884 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 693444006885 putative lipoprotein/autotransporter domain-containing protein; Provisional; Region: PRK14849 693444006886 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 693444006887 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 693444006888 Autotransporter beta-domain; Region: Autotransporter; pfam03797 693444006889 Uncharacterized homolog of Blt101 [Function unknown]; Region: COG0401 693444006890 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 693444006891 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 693444006892 non-specific DNA binding site [nucleotide binding]; other site 693444006893 salt bridge; other site 693444006894 sequence-specific DNA binding site [nucleotide binding]; other site 693444006895 HipA N-terminal domain; Region: Couple_hipA; pfam13657 693444006896 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 693444006897 HipA-like N-terminal domain; Region: HipA_N; pfam07805 693444006898 HipA-like C-terminal domain; Region: HipA_C; pfam07804 693444006899 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 693444006900 Maltooligosyl trehalose synthase [Carbohydrate transport and metabolism]; Region: TreY; COG3280 693444006901 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 693444006902 active site 693444006903 catalytic site [active] 693444006904 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 693444006905 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 693444006906 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 693444006907 catalytic site [active] 693444006908 active site 693444006909 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 693444006910 oxidoreductase; Provisional; Region: PRK06128 693444006911 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 693444006912 NAD binding site [chemical binding]; other site 693444006913 metal binding site [ion binding]; metal-binding site 693444006914 active site 693444006915 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 693444006916 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 693444006917 catalytic residue [active] 693444006918 diaminobutyrate--2-oxoglutarate aminotransferase; Provisional; Region: PRK06931 693444006919 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 693444006920 inhibitor-cofactor binding pocket; inhibition site 693444006921 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693444006922 catalytic residue [active] 693444006923 aspartate kinase III; Validated; Region: PRK09084 693444006924 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 693444006925 nucleotide binding site [chemical binding]; other site 693444006926 substrate binding site [chemical binding]; other site 693444006927 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 693444006928 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 693444006929 Uncharacterized conserved protein (DUF2132); Region: DUF2132; pfam09905 693444006930 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649 693444006931 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 693444006932 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 693444006933 BON domain; Region: BON; pfam04972 693444006934 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 693444006935 Putative transcription activator [Transcription]; Region: TenA; COG0819 693444006936 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 693444006937 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693444006938 Walker A/P-loop; other site 693444006939 ATP binding site [chemical binding]; other site 693444006940 Q-loop/lid; other site 693444006941 ABC transporter signature motif; other site 693444006942 Walker B; other site 693444006943 D-loop; other site 693444006944 H-loop/switch region; other site 693444006945 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 693444006946 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693444006947 dimer interface [polypeptide binding]; other site 693444006948 conserved gate region; other site 693444006949 putative PBP binding loops; other site 693444006950 ABC-ATPase subunit interface; other site 693444006951 NMT1/THI5 like; Region: NMT1; pfam09084 693444006952 NLPA lipoprotein; Region: Lipoprotein_9; cl17547 693444006953 malate:quinone oxidoreductase; Validated; Region: PRK05257 693444006954 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 693444006955 Predicted membrane protein [Function unknown]; Region: COG3781 693444006956 altronate oxidoreductase; Provisional; Region: PRK03643 693444006957 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 693444006958 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 693444006959 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 693444006960 Coenzyme A binding pocket [chemical binding]; other site 693444006961 Domain of unknown function (DUF4186); Region: DUF4186; pfam13811 693444006962 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 693444006963 glutaminase; Provisional; Region: PRK00971 693444006964 Hok/gef family; Region: HOK_GEF; pfam01848 693444006965 putative succinate semialdehyde dehydrogenase; Provisional; Region: PRK13968 693444006966 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 693444006967 NAD(P) binding site [chemical binding]; other site 693444006968 catalytic residues [active] 693444006969 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693444006970 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693444006971 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 693444006972 putative dimerization interface [polypeptide binding]; other site 693444006973 Predicted transcriptional regulator [Transcription]; Region: COG4190 693444006974 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 693444006975 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 693444006976 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 693444006977 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 693444006978 4-hydroxythreonine-4-phosphate dehydrogenase 2; Provisional; Region: pdxA; PRK03371 693444006979 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 693444006980 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 693444006981 5-hydroxyvalerate dehydrogenase (HVD) catalyzes the oxidation of 5-hydroxyvalerate to 5-oxovalerate with NAD+ as cofactor; Region: HVD; cd08193 693444006982 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 693444006983 putative active site [active] 693444006984 metal binding site [ion binding]; metal-binding site 693444006985 dihydrodipicolinate synthase; Region: dapA; TIGR00674 693444006986 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 693444006987 inhibitor site; inhibition site 693444006988 active site 693444006989 dimer interface [polypeptide binding]; other site 693444006990 catalytic residue [active] 693444006991 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 693444006992 Predicted neuraminidase (sialidase) [Carbohydrate transport and metabolism]; Region: COG4692 693444006993 BNR repeat-like domain; Region: BNR_2; pfam13088 693444006994 Domain of unknown function (DUF386); Region: DUF386; cl01047 693444006995 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 693444006996 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 693444006997 transmembrane helices; other site 693444006998 putative arabinose transporter; Provisional; Region: PRK03545 693444006999 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693444007000 putative substrate translocation pore; other site 693444007001 inner membrane protein; Provisional; Region: PRK10995 693444007002 DNA-binding transcriptional repressor MarR; Provisional; Region: PRK11512 693444007003 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 693444007004 DNA-binding transcriptional activator MarA; Provisional; Region: PRK11511 693444007005 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 693444007006 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 693444007007 MarB protein; Region: MarB; pfam13999 693444007008 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 693444007009 EamA-like transporter family; Region: EamA; pfam00892 693444007010 putative transporter; Provisional; Region: PRK10054 693444007011 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693444007012 putative substrate translocation pore; other site 693444007013 Member of the Rhodanese Homology Domain superfamily. This CD includes the putative rhodanese-like protein, Psp2, of Yersinia pestis biovar Medievalis and other similar uncharacterized proteins; Region: RHOD_PspE2; cd01521 693444007014 active site residue [active] 693444007015 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 693444007016 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 693444007017 conserved cys residue [active] 693444007018 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 693444007019 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 693444007020 Na(+)-translocating NADH-quinone reductase subunit E; Provisional; Region: PRK02830 693444007021 dipeptidyl carboxypeptidase II; Provisional; Region: PRK10280 693444007022 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 693444007023 active site 693444007024 Zn binding site [ion binding]; other site 693444007025 malonic semialdehyde reductase; Provisional; Region: PRK10538 693444007026 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 693444007027 putative NAD(P) binding site [chemical binding]; other site 693444007028 homodimer interface [polypeptide binding]; other site 693444007029 homotetramer interface [polypeptide binding]; other site 693444007030 active site 693444007031 Transcriptional regulators [Transcription]; Region: GntR; COG1802 693444007032 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 693444007033 DNA-binding site [nucleotide binding]; DNA binding site 693444007034 FCD domain; Region: FCD; pfam07729 693444007035 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 693444007036 Ligand Binding Site [chemical binding]; other site 693444007037 YdfZ protein; Region: YdfZ; pfam14001 693444007038 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 693444007039 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 693444007040 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 693444007041 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693444007042 metabolite-proton symporter; Region: 2A0106; TIGR00883 693444007043 putative substrate translocation pore; other site 693444007044 putative oxidoreductase; Provisional; Region: PRK10083 693444007045 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 693444007046 putative NAD(P) binding site [chemical binding]; other site 693444007047 catalytic Zn binding site [ion binding]; other site 693444007048 structural Zn binding site [ion binding]; other site 693444007049 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 693444007050 The starvation sensing protein RpsA from E.coli and its homologs are lactonizing enzymes whose putative targets are homoserine lactone (HSL)-derivative. They are part of the mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of...; Region: rpsA; cd03322 693444007051 putative active site pocket [active] 693444007052 putative metal binding site [ion binding]; other site 693444007053 hypothetical protein; Provisional; Region: PRK02237 693444007054 hypothetical protein; Provisional; Region: PRK13659 693444007055 spermidine N1-acetyltransferase; Provisional; Region: PRK15130 693444007056 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 693444007057 Uncharacterized protein family (UPF0257); Region: UPF0257; cl14672 693444007058 Protein of unknown function (DUF1161); Region: DUF1161; pfam06649 693444007059 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 693444007060 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 693444007061 putative [Fe4-S4] binding site [ion binding]; other site 693444007062 putative molybdopterin cofactor binding site [chemical binding]; other site 693444007063 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 693444007064 putative molybdopterin cofactor binding site; other site 693444007065 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 693444007066 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 693444007067 putative [Fe4-S4] binding site [ion binding]; other site 693444007068 putative molybdopterin cofactor binding site [chemical binding]; other site 693444007069 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 693444007070 putative molybdopterin cofactor binding site; other site 693444007071 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 693444007072 4Fe-4S binding domain; Region: Fer4; pfam00037 693444007073 DMSO reductase anchor subunit [General function prediction only]; Region: DmsC; COG3302 693444007074 twin-argninine leader-binding protein DmsD; Provisional; Region: PRK11621 693444007075 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693444007076 dimer interface [polypeptide binding]; other site 693444007077 conserved gate region; other site 693444007078 putative PBP binding loops; other site 693444007079 ABC-ATPase subunit interface; other site 693444007080 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 693444007081 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693444007082 dimer interface [polypeptide binding]; other site 693444007083 conserved gate region; other site 693444007084 ABC-ATPase subunit interface; other site 693444007085 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 693444007086 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 693444007087 Walker A/P-loop; other site 693444007088 ATP binding site [chemical binding]; other site 693444007089 Q-loop/lid; other site 693444007090 ABC transporter signature motif; other site 693444007091 Walker B; other site 693444007092 D-loop; other site 693444007093 H-loop/switch region; other site 693444007094 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc; cd04582 693444007095 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 693444007096 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 693444007097 Cl- selectivity filter; other site 693444007098 Cl- binding residues [ion binding]; other site 693444007099 pore gating glutamate residue; other site 693444007100 dimer interface [polypeptide binding]; other site 693444007101 putative dithiobiotin synthetase; Provisional; Region: PRK12374 693444007102 AAA domain; Region: AAA_26; pfam13500 693444007103 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 693444007104 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 693444007105 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 693444007106 nucleotide binding site [chemical binding]; other site 693444007107 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693444007108 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693444007109 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 693444007110 dimerization interface [polypeptide binding]; other site 693444007111 substrate binding pocket [chemical binding]; other site 693444007112 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693444007113 Major Facilitator Superfamily; Region: MFS_1; pfam07690 693444007114 putative substrate translocation pore; other site 693444007115 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 693444007116 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 693444007117 active site 693444007118 Zn binding site [ion binding]; other site 693444007119 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 693444007120 multidrug efflux system protein MdtI; Provisional; Region: PRK10650 693444007121 multidrug efflux system protein MdtJ; Provisional; Region: PRK10452 693444007122 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; PRK12287 693444007123 Domain of unknown function DUF20; Region: UPF0118; pfam01594 693444007124 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 693444007125 TetR family transcriptional regulator; Provisional; Region: PRK14996 693444007126 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 693444007127 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 693444007128 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 693444007129 active site 693444007130 DNA binding site [nucleotide binding] 693444007131 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 693444007132 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 693444007133 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 693444007134 Catalytic site [active] 693444007135 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 693444007136 Mechanosensitive ion channel; Region: MS_channel; pfam00924 693444007137 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 693444007138 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 693444007139 SCP-2 sterol transfer family; Region: SCP2; pfam02036 693444007140 outer membrane protein A; Reviewed; Region: PRK10808 693444007141 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 693444007142 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 693444007143 ligand binding site [chemical binding]; other site 693444007144 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11832 693444007145 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 693444007146 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 693444007147 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 693444007148 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 693444007149 dimer interface [polypeptide binding]; other site 693444007150 Citrate synthase; Region: Citrate_synt; pfam00285 693444007151 active site 693444007152 citrylCoA binding site [chemical binding]; other site 693444007153 NADH binding [chemical binding]; other site 693444007154 cationic pore residues; other site 693444007155 oxalacetate/citrate binding site [chemical binding]; other site 693444007156 coenzyme A binding site [chemical binding]; other site 693444007157 catalytic triad [active] 693444007158 Hok/gef family; Region: HOK_GEF; pfam01848 693444007159 Domain of unknown function (DUF4156); Region: DUF4156; pfam13698 693444007160 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 693444007161 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 693444007162 tetrameric interface [polypeptide binding]; other site 693444007163 NAD binding site [chemical binding]; other site 693444007164 catalytic residues [active] 693444007165 substrate binding site [chemical binding]; other site 693444007166 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 693444007167 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 693444007168 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693444007169 dimer interface [polypeptide binding]; other site 693444007170 conserved gate region; other site 693444007171 putative PBP binding loops; other site 693444007172 ABC-ATPase subunit interface; other site 693444007173 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693444007174 dimer interface [polypeptide binding]; other site 693444007175 conserved gate region; other site 693444007176 putative PBP binding loops; other site 693444007177 ABC-ATPase subunit interface; other site 693444007178 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 693444007179 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693444007180 Walker A/P-loop; other site 693444007181 ATP binding site [chemical binding]; other site 693444007182 Q-loop/lid; other site 693444007183 ABC transporter signature motif; other site 693444007184 Walker B; other site 693444007185 D-loop; other site 693444007186 H-loop/switch region; other site 693444007187 TOBE domain; Region: TOBE_2; pfam08402 693444007188 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 693444007189 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 693444007190 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 693444007191 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 693444007192 DNA-binding site [nucleotide binding]; DNA binding site 693444007193 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 693444007194 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693444007195 homodimer interface [polypeptide binding]; other site 693444007196 catalytic residue [active] 693444007197 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 693444007198 nickel/cobalt efflux protein RcnA; Provisional; Region: PRK10019 693444007199 nickel/cobalt efflux protein RcnA; Provisional; Region: PRK10019 693444007200 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 693444007201 putative metal binding site [ion binding]; other site 693444007202 putative homodimer interface [polypeptide binding]; other site 693444007203 putative homotetramer interface [polypeptide binding]; other site 693444007204 putative homodimer-homodimer interface [polypeptide binding]; other site 693444007205 putative allosteric switch controlling residues; other site 693444007206 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 693444007207 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 693444007208 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 693444007209 Protein of unknown function (DUF2474); Region: DUF2474; pfam10617 693444007210 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 693444007211 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 693444007212 Peptidase family U32; Region: Peptidase_U32; pfam01136 693444007213 Collagenase; Region: DUF3656; pfam12392 693444007214 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 693444007215 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 693444007216 non-specific DNA binding site [nucleotide binding]; other site 693444007217 salt bridge; other site 693444007218 sequence-specific DNA binding site [nucleotide binding]; other site 693444007219 Cupin domain; Region: Cupin_2; pfam07883 693444007220 Uncharacterized protein involved in benzoate metabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BenE; COG3135 693444007221 benzoate transporter; Region: benE; TIGR00843 693444007222 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 693444007223 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 693444007224 EamA-like transporter family; Region: EamA; pfam00892 693444007225 Protein of unknown function (DUF3313); Region: DUF3313; pfam11769 693444007226 tellurite resistance protein TehB; Provisional; Region: PRK11207 693444007227 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693444007228 S-adenosylmethionine binding site [chemical binding]; other site 693444007229 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 693444007230 Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes TehA protein; Region: TDT_TehA; cd09324 693444007231 gating phenylalanine in ion channel; other site 693444007232 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 693444007233 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cd00208 693444007234 putative trimer interface [polypeptide binding]; other site 693444007235 putative CoA binding site [chemical binding]; other site 693444007236 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 693444007237 putative trimer interface [polypeptide binding]; other site 693444007238 putative CoA binding site [chemical binding]; other site 693444007239 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 693444007240 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 693444007241 Coenzyme A binding pocket [chemical binding]; other site 693444007242 Periplasmic glucans biosynthesis protein [Inorganic ion transport and metabolism]; Region: MdoG; COG3131 693444007243 glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273 693444007244 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 693444007245 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 693444007246 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 693444007247 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 693444007248 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 693444007249 substrate binding pocket [chemical binding]; other site 693444007250 catalytic triad [active] 693444007251 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 693444007252 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 693444007253 Protocatechuate 3,4-dioxygenase (3,4-PCD) , beta subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_beta; cd03464 693444007254 heterodimer interface [polypeptide binding]; other site 693444007255 multimer interface [polypeptide binding]; other site 693444007256 protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422 693444007257 active site 693444007258 Protocatechuate 3,4-dioxygenase beta subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PcaH; COG3485 693444007259 Protocatechuate 3,4-dioxygenase (3,4-PCD) , alpha subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_alpha; cd03463 693444007260 heterodimer interface [polypeptide binding]; other site 693444007261 active site 693444007262 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 693444007263 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693444007264 The C-terminal substrate binding domain of galactose-binding protein regulator contains the type 2 periplasmic binding fold; Region: PBP2_GbpR; cd08435 693444007265 putative dimerization interface [polypeptide binding]; other site 693444007266 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 693444007267 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 693444007268 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 693444007269 Trp docking motif [polypeptide binding]; other site 693444007270 putative active site [active] 693444007271 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 693444007272 dimer interface [polypeptide binding]; other site 693444007273 ligand binding site [chemical binding]; other site 693444007274 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 693444007275 dimerization interface [polypeptide binding]; other site 693444007276 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 693444007277 dimer interface [polypeptide binding]; other site 693444007278 putative CheW interface [polypeptide binding]; other site 693444007279 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 693444007280 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 693444007281 substrate binding site [chemical binding]; other site 693444007282 catalytic Zn binding site [ion binding]; other site 693444007283 NAD binding site [chemical binding]; other site 693444007284 structural Zn binding site [ion binding]; other site 693444007285 dimer interface [polypeptide binding]; other site 693444007286 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 693444007287 putative metal binding site [ion binding]; other site 693444007288 putative homodimer interface [polypeptide binding]; other site 693444007289 putative homotetramer interface [polypeptide binding]; other site 693444007290 putative homodimer-homodimer interface [polypeptide binding]; other site 693444007291 putative allosteric switch controlling residues; other site 693444007292 Hok/gef family; Region: HOK_GEF; pfam01848 693444007293 Hok/gef family; Region: HOK_GEF; pfam01848 693444007294 leucine export protein LeuE; Provisional; Region: PRK10958 693444007295 cytochrome b561; Provisional; Region: PRK11513 693444007296 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 693444007297 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 693444007298 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 693444007299 Uncharacterized conserved protein [Function unknown]; Region: COG1434 693444007300 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 693444007301 putative active site [active] 693444007302 metabolite-proton symporter; Region: 2A0106; TIGR00883 693444007303 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693444007304 putative substrate translocation pore; other site 693444007305 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 693444007306 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 693444007307 ATP binding site [chemical binding]; other site 693444007308 putative Mg++ binding site [ion binding]; other site 693444007309 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 693444007310 nucleotide binding region [chemical binding]; other site 693444007311 ATP-binding site [chemical binding]; other site 693444007312 Helicase associated domain (HA2); Region: HA2; pfam04408 693444007313 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 693444007314 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 693444007315 azoreductase; Reviewed; Region: PRK00170 693444007316 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 693444007317 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 693444007318 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 693444007319 active site 693444007320 catalytic tetrad [active] 693444007321 phenylacetic acid degradation protein PaaY; Region: PaaY; TIGR02287 693444007322 paaY-like: This group is composed by uncharacterized proteins with similarity to the protein product of the E. coli paaY gene, which is part of the paa gene cluster responsible for phenylacetic acid degradation. Proteins in this group are expected to...; Region: LbH_paaY_like; cd04745 693444007323 putative trimer interface [polypeptide binding]; other site 693444007324 putative metal binding site [ion binding]; other site 693444007325 PaaX-like protein; Region: PaaX; pfam07848 693444007326 phenylacetic acid degradation operon negative regulatory protein PaaX; Region: PaaX_trns_reg; TIGR02277 693444007327 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 693444007328 Phenylacetate-CoA ligase (also known as PaaK); Region: PaaK; cd05913 693444007329 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 693444007330 active site 693444007331 AMP binding site [chemical binding]; other site 693444007332 homodimer interface [polypeptide binding]; other site 693444007333 acyl-activating enzyme (AAE) consensus motif; other site 693444007334 CoA binding site [chemical binding]; other site 693444007335 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 693444007336 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 693444007337 dimer interface [polypeptide binding]; other site 693444007338 active site 693444007339 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 693444007340 CoenzymeA binding site [chemical binding]; other site 693444007341 subunit interaction site [polypeptide binding]; other site 693444007342 PHB binding site; other site 693444007343 3-hydroxy-acyl-CoA dehydrogenase; Validated; Region: PRK08268 693444007344 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 693444007345 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 693444007346 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 693444007347 enoyl-CoA hydratase; Provisional; Region: PRK08140 693444007348 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 693444007349 substrate binding site [chemical binding]; other site 693444007350 oxyanion hole (OAH) forming residues; other site 693444007351 trimer interface [polypeptide binding]; other site 693444007352 enoyl-CoA hydratase-isomerase; Provisional; Region: PRK09674 693444007353 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 693444007354 substrate binding site [chemical binding]; other site 693444007355 oxyanion hole (OAH) forming residues; other site 693444007356 trimer interface [polypeptide binding]; other site 693444007357 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 693444007358 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 693444007359 FAD binding pocket [chemical binding]; other site 693444007360 FAD binding motif [chemical binding]; other site 693444007361 phosphate binding motif [ion binding]; other site 693444007362 beta-alpha-beta structure motif; other site 693444007363 NAD(p) ribose binding residues [chemical binding]; other site 693444007364 NAD binding pocket [chemical binding]; other site 693444007365 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 693444007366 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 693444007367 catalytic loop [active] 693444007368 iron binding site [ion binding]; other site 693444007369 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 693444007370 phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159 693444007371 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; pfam05138 693444007372 phenylacetate-CoA oxygenase subunit PaaB; Provisional; Region: paaB; PRK13781 693444007373 phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778 693444007374 phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156 693444007375 bifunctional aldehyde dehydrogenase/enoyl-CoA hydratase; Provisional; Region: PRK11563 693444007376 N-terminal domain of the monoamine oxidase C dehydratase; Region: ALDH_MaoC-N; cd07128 693444007377 substrate binding site [chemical binding]; other site 693444007378 dimer interface [polypeptide binding]; other site 693444007379 NADP binding site [chemical binding]; other site 693444007380 catalytic residues [active] 693444007381 MaoC_C The C-terminal hot dog fold of the MaoC (monoamine oxidase C) dehydratase regulatory protein. Orthologs of MaoC include PaaZ [Escherichia coli] and PaaN [Pseudomonas putida], which are putative ring-opening enzymes involved in phenylacetic acid...; Region: MaoC_C; cd03452 693444007382 substrate binding site [chemical binding]; other site 693444007383 tyramine oxidase; Provisional; Region: tynA; PRK14696 693444007384 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 693444007385 Copper amine oxidase, N2 domain; Region: Cu_amine_oxidN2; pfam02727 693444007386 Copper amine oxidase, N3 domain; Region: Cu_amine_oxidN3; pfam02728 693444007387 Copper amine oxidase, enzyme domain; Region: Cu_amine_oxid; pfam01179 693444007388 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 693444007389 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 693444007390 NAD(P) binding site [chemical binding]; other site 693444007391 catalytic residues [active] 693444007392 DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685 693444007393 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 693444007394 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3784 693444007395 YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617 693444007396 hypothetical protein; Provisional; Region: PRK10695 693444007397 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 693444007398 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 693444007399 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 693444007400 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 693444007401 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 693444007402 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 693444007403 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 693444007404 active site 693444007405 P-loop; other site 693444007406 phosphorylation site [posttranslational modification] 693444007407 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 693444007408 active site 693444007409 phosphorylation site [posttranslational modification] 693444007410 Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005 693444007411 tetramer interface [polypeptide binding]; other site 693444007412 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 693444007413 active site 693444007414 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 693444007415 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 693444007416 putative ligand binding site [chemical binding]; other site 693444007417 putative NAD binding site [chemical binding]; other site 693444007418 catalytic site [active] 693444007419 Protein of unknown function (DUF1861); Region: DUF1861; pfam08950 693444007420 Predicted glycosylase [Carbohydrate transport and metabolism]; Region: COG2152 693444007421 active site 693444007422 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 693444007423 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 693444007424 Ca binding site [ion binding]; other site 693444007425 active site 693444007426 catalytic site [active] 693444007427 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 693444007428 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693444007429 dimer interface [polypeptide binding]; other site 693444007430 conserved gate region; other site 693444007431 putative PBP binding loops; other site 693444007432 ABC-ATPase subunit interface; other site 693444007433 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 693444007434 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693444007435 putative PBP binding loops; other site 693444007436 dimer interface [polypeptide binding]; other site 693444007437 ABC-ATPase subunit interface; other site 693444007438 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 693444007439 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 693444007440 Transcriptional regulators [Transcription]; Region: PurR; COG1609 693444007441 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 693444007442 DNA binding site [nucleotide binding] 693444007443 domain linker motif; other site 693444007444 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 693444007445 phosphomannomutase CpsG; Provisional; Region: PRK15414 693444007446 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 693444007447 active site 693444007448 substrate binding site [chemical binding]; other site 693444007449 metal binding site [ion binding]; metal-binding site 693444007450 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 693444007451 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 693444007452 Walker A/P-loop; other site 693444007453 ATP binding site [chemical binding]; other site 693444007454 Q-loop/lid; other site 693444007455 ABC transporter signature motif; other site 693444007456 Walker B; other site 693444007457 D-loop; other site 693444007458 H-loop/switch region; other site 693444007459 TOBE domain; Region: TOBE_2; pfam08402 693444007460 META domain; Region: META; cl01245 693444007461 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 693444007462 Domain of unknown function (DUF333); Region: DUF333; pfam03891 693444007463 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 693444007464 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 693444007465 dimer interface [polypeptide binding]; other site 693444007466 PYR/PP interface [polypeptide binding]; other site 693444007467 TPP binding site [chemical binding]; other site 693444007468 substrate binding site [chemical binding]; other site 693444007469 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 693444007470 Domain of unknown function; Region: EKR; pfam10371 693444007471 4Fe-4S binding domain; Region: Fer4_6; pfam12837 693444007472 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 693444007473 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 693444007474 TPP-binding site [chemical binding]; other site 693444007475 dimer interface [polypeptide binding]; other site 693444007476 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 693444007477 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 693444007478 trimer interface [polypeptide binding]; other site 693444007479 eyelet of channel; other site 693444007480 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 693444007481 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 693444007482 metal-binding site [ion binding] 693444007483 MerT mercuric transport protein; Region: MerT; cl03578 693444007484 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 693444007485 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 693444007486 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 693444007487 conjugal transfer protein TrbH; Provisional; Region: PRK13883 693444007488 Protein of unknown function (DUF1398); Region: DUF1398; cl11576 693444007489 hypothetical protein; Provisional; Region: PRK10040 693444007490 Homeodomain-like domain; Region: HTH_23; cl17451 693444007491 Winged helix-turn helix; Region: HTH_29; pfam13551 693444007492 Homeodomain-like domain; Region: HTH_32; pfam13565 693444007493 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 693444007494 Integrase core domain; Region: rve; pfam00665 693444007495 Integrase core domain; Region: rve_3; pfam13683 693444007496 Hok/gef family; Region: HOK_GEF; pfam01848 693444007497 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 693444007498 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 693444007499 Ligand Binding Site [chemical binding]; other site 693444007500 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 693444007501 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 693444007502 ATP binding site [chemical binding]; other site 693444007503 Mg++ binding site [ion binding]; other site 693444007504 motif III; other site 693444007505 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 693444007506 nucleotide binding region [chemical binding]; other site 693444007507 ATP-binding site [chemical binding]; other site 693444007508 RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501 693444007509 putative RNA binding site [nucleotide binding]; other site 693444007510 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 693444007511 Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; Region: ZntB-like_1; cd12833 693444007512 Cl binding site [ion binding]; other site 693444007513 oligomer interface [polypeptide binding]; other site 693444007514 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 693444007515 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 693444007516 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693444007517 metal binding site [ion binding]; metal-binding site 693444007518 active site 693444007519 I-site; other site 693444007520 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 693444007521 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 693444007522 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 693444007523 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 693444007524 putative active site [active] 693444007525 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 693444007526 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 693444007527 putative active site cavity [active] 693444007528 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 693444007529 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 693444007530 Protein of unknown function (DUF4127); Region: DUF4127; pfam13552 693444007531 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 693444007532 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 693444007533 peptide binding site [polypeptide binding]; other site 693444007534 Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866 693444007535 Peptidase M14-like domain of Escherichia coli Murein Peptide Amidase A and related proteins; Region: M14_MpaA_like; cd06904 693444007536 putative active site [active] 693444007537 Zn binding site [ion binding]; other site 693444007538 L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129 693444007539 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 693444007540 active site 693444007541 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 693444007542 dimer interface [polypeptide binding]; other site 693444007543 catalytic triad [active] 693444007544 peroxidatic and resolving cysteines [active] 693444007545 DNA-binding transcriptional regulator TyrR; Provisional; Region: PRK10820 693444007546 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 693444007547 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 693444007548 putative active site [active] 693444007549 heme pocket [chemical binding]; other site 693444007550 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693444007551 Walker A motif; other site 693444007552 ATP binding site [chemical binding]; other site 693444007553 Walker B motif; other site 693444007554 arginine finger; other site 693444007555 hypothetical protein; Provisional; Region: PRK05415 693444007556 Domain of unknown function (DUF697); Region: DUF697; cl12064 693444007557 Predicted ATPase [General function prediction only]; Region: COG3106 693444007558 peripheral inner membrane phage-shock protein; Provisional; Region: PRK10497 693444007559 DNA-binding transcriptional activator PspC; Provisional; Region: PRK10697 693444007560 phage shock protein C; Region: phageshock_pspC; TIGR02978 693444007561 phage shock protein B; Provisional; Region: pspB; PRK09458 693444007562 phage shock protein PspA; Provisional; Region: PRK10698 693444007563 phage shock protein operon transcriptional activator; Provisional; Region: pspF; PRK11608 693444007564 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693444007565 Walker A motif; other site 693444007566 ATP binding site [chemical binding]; other site 693444007567 Walker B motif; other site 693444007568 arginine finger; other site 693444007569 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 693444007570 PrpA and PrpB, metallophosphatase domain; Region: MPP_PrpA_PrpB; cd07424 693444007571 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 693444007572 active site 693444007573 metal binding site [ion binding]; metal-binding site 693444007574 Cache domain; Region: Cache_1; pfam02743 693444007575 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 693444007576 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693444007577 metal binding site [ion binding]; metal-binding site 693444007578 active site 693444007579 I-site; other site 693444007580 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 693444007581 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 693444007582 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 693444007583 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 693444007584 peptide binding site [polypeptide binding]; other site 693444007585 antimicrobial peptide ABC transporter permease SapB; Provisional; Region: PRK15110 693444007586 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693444007587 dimer interface [polypeptide binding]; other site 693444007588 conserved gate region; other site 693444007589 putative PBP binding loops; other site 693444007590 ABC-ATPase subunit interface; other site 693444007591 antimicrobial peptide ABC transporter permease SapC; Provisional; Region: PRK15111 693444007592 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 693444007593 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693444007594 dimer interface [polypeptide binding]; other site 693444007595 conserved gate region; other site 693444007596 putative PBP binding loops; other site 693444007597 ABC-ATPase subunit interface; other site 693444007598 antimicrobial peptide ABC transporter ATP-binding protein; Provisional; Region: PRK15093 693444007599 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 693444007600 Walker A/P-loop; other site 693444007601 ATP binding site [chemical binding]; other site 693444007602 Q-loop/lid; other site 693444007603 ABC transporter signature motif; other site 693444007604 Walker B; other site 693444007605 D-loop; other site 693444007606 H-loop/switch region; other site 693444007607 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 693444007608 antimicrobial peptide ABC system ATP-binding protein SapF; Provisional; Region: PRK15112 693444007609 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 693444007610 Walker A/P-loop; other site 693444007611 ATP binding site [chemical binding]; other site 693444007612 Q-loop/lid; other site 693444007613 ABC transporter signature motif; other site 693444007614 Walker B; other site 693444007615 D-loop; other site 693444007616 H-loop/switch region; other site 693444007617 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07984 693444007618 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 693444007619 NAD binding site [chemical binding]; other site 693444007620 homotetramer interface [polypeptide binding]; other site 693444007621 homodimer interface [polypeptide binding]; other site 693444007622 substrate binding site [chemical binding]; other site 693444007623 active site 693444007624 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950 693444007625 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 693444007626 exoribonuclease II; Provisional; Region: PRK05054 693444007627 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 693444007628 RNB domain; Region: RNB; pfam00773 693444007629 S1 RNA binding domain; Region: S1; pfam00575 693444007630 hypothetical protein; Provisional; Region: PRK13658 693444007631 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 693444007632 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 693444007633 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 693444007634 lipoprotein; Provisional; Region: PRK10540 693444007635 translation initiation factor Sui1; Validated; Region: PRK06824 693444007636 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 693444007637 putative rRNA binding site [nucleotide binding]; other site 693444007638 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 693444007639 active site 693444007640 dimer interface [polypeptide binding]; other site 693444007641 tetratricopeptide repeat protein; Provisional; Region: PRK11788 693444007642 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 693444007643 binding surface 693444007644 TPR motif; other site 693444007645 Predicted membrane protein [Function unknown]; Region: COG3771 693444007646 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 693444007647 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 693444007648 active site 693444007649 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 693444007650 dimerization interface [polypeptide binding]; other site 693444007651 active site 693444007652 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 693444007653 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693444007654 Walker A/P-loop; other site 693444007655 ATP binding site [chemical binding]; other site 693444007656 Q-loop/lid; other site 693444007657 ABC transporter signature motif; other site 693444007658 Walker B; other site 693444007659 D-loop; other site 693444007660 H-loop/switch region; other site 693444007661 TOBE domain; Region: TOBE; pfam03459 693444007662 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 693444007663 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693444007664 dimer interface [polypeptide binding]; other site 693444007665 conserved gate region; other site 693444007666 putative PBP binding loops; other site 693444007667 ABC-ATPase subunit interface; other site 693444007668 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693444007669 dimer interface [polypeptide binding]; other site 693444007670 conserved gate region; other site 693444007671 putative PBP binding loops; other site 693444007672 ABC-ATPase subunit interface; other site 693444007673 aconitate hydratase; Validated; Region: PRK09277 693444007674 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 693444007675 substrate binding site [chemical binding]; other site 693444007676 ligand binding site [chemical binding]; other site 693444007677 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 693444007678 substrate binding site [chemical binding]; other site 693444007679 transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681 693444007680 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693444007681 The C-terminal substrate domain of LysR-type transcriptional regulator CysB contains type 2 periplasmic binding fold; Region: PBP2_CysB; cd08443 693444007682 substrate binding site [chemical binding]; other site 693444007683 putative dimerization interface [polypeptide binding]; other site 693444007684 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 693444007685 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 693444007686 active site 693444007687 interdomain interaction site; other site 693444007688 putative metal-binding site [ion binding]; other site 693444007689 nucleotide binding site [chemical binding]; other site 693444007690 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 693444007691 domain I; other site 693444007692 DNA binding groove [nucleotide binding] 693444007693 phosphate binding site [ion binding]; other site 693444007694 domain II; other site 693444007695 domain III; other site 693444007696 nucleotide binding site [chemical binding]; other site 693444007697 catalytic site [active] 693444007698 domain IV; other site 693444007699 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 693444007700 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 693444007701 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 693444007702 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 693444007703 hypothetical protein; Provisional; Region: PRK11037 693444007704 Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496 693444007705 putative inner membrane peptidase; Provisional; Region: PRK11778 693444007706 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 693444007707 tandem repeat interface [polypeptide binding]; other site 693444007708 oligomer interface [polypeptide binding]; other site 693444007709 active site residues [active] 693444007710 putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945 693444007711 Escherichia coli K-12 YCIK-like, classical (c) SDRs; Region: Ycik_SDR_c; cd05340 693444007712 NADP binding site [chemical binding]; other site 693444007713 homodimer interface [polypeptide binding]; other site 693444007714 active site 693444007715 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 693444007716 cob(I)alamin adenolsyltransferase/cobinamide ATP-dependent adenolsyltransferase; Validated; Region: PRK05986 693444007717 outer membrane receptor FepA; Provisional; Region: PRK13528 693444007718 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 693444007719 N-terminal plug; other site 693444007720 ligand-binding site [chemical binding]; other site 693444007721 23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700 693444007722 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 693444007723 RNA binding surface [nucleotide binding]; other site 693444007724 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 693444007725 probable active site [active] 693444007726 hypothetical protein; Provisional; Region: PRK11630 693444007727 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 693444007728 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 693444007729 active site 693444007730 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 693444007731 Tryptophan operon leader; D782_2442; IMG reference gene:2507517138 693444007732 anthranilate synthase component I; Provisional; Region: PRK13564 693444007733 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 693444007734 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 693444007735 bifunctional glutamine amidotransferase/anthranilate phosphoribosyltransferase; Provisional; Region: PRK09522 693444007736 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 693444007737 glutamine binding [chemical binding]; other site 693444007738 catalytic triad [active] 693444007739 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 693444007740 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 693444007741 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427 693444007742 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 693444007743 active site 693444007744 ribulose/triose binding site [chemical binding]; other site 693444007745 phosphate binding site [ion binding]; other site 693444007746 substrate (anthranilate) binding pocket [chemical binding]; other site 693444007747 product (indole) binding pocket [chemical binding]; other site 693444007748 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 693444007749 active site 693444007750 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 693444007751 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 693444007752 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693444007753 catalytic residue [active] 693444007754 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 693444007755 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 693444007756 substrate binding site [chemical binding]; other site 693444007757 active site 693444007758 catalytic residues [active] 693444007759 heterodimer interface [polypeptide binding]; other site 693444007760 diguanylate cyclase; Provisional; Region: PRK09894 693444007761 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 693444007762 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693444007763 metal binding site [ion binding]; metal-binding site 693444007764 active site 693444007765 I-site; other site 693444007766 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 693444007767 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693444007768 metal binding site [ion binding]; metal-binding site 693444007769 active site 693444007770 I-site; other site 693444007771 outer membrane protein W; Provisional; Region: PRK10959 693444007772 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 693444007773 hypothetical protein; Provisional; Region: PRK02868 693444007774 intracellular septation protein A; Reviewed; Region: PRK00259 693444007775 Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta) domain...; Region: PL_Passenger_AT; cl00185 693444007776 Autotransporter beta-domain; Region: Autotransporter; pfam03797 693444007777 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 693444007778 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 693444007779 catalytic residues [active] 693444007780 catalytic nucleophile [active] 693444007781 Presynaptic Site I dimer interface [polypeptide binding]; other site 693444007782 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 693444007783 Synaptic Flat tetramer interface [polypeptide binding]; other site 693444007784 Synaptic Site I dimer interface [polypeptide binding]; other site 693444007785 DNA binding site [nucleotide binding] 693444007786 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 693444007787 DNA-binding interface [nucleotide binding]; DNA binding site 693444007788 Phage-related protein, tail component [Function unknown]; Region: COG4733 693444007789 Putative phage tail protein; Region: Phage-tail_3; pfam13550 693444007790 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 693444007791 Interdomain contacts; other site 693444007792 Cytokine receptor motif; other site 693444007793 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 693444007794 Phage-related protein, tail component [Function unknown]; Region: COG4723 693444007795 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 693444007796 Predicted transcriptional regulators [Transcription]; Region: COG1733 693444007797 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 693444007798 dimerization interface [polypeptide binding]; other site 693444007799 putative DNA binding site [nucleotide binding]; other site 693444007800 putative Zn2+ binding site [ion binding]; other site 693444007801 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 693444007802 MPN+ (JAMM) motif; other site 693444007803 Zinc-binding site [ion binding]; other site 693444007804 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 693444007805 NlpC/P60 family; Region: NLPC_P60; pfam00877 693444007806 Phage minor tail protein L; Region: Phage_tail_L; cl01908 693444007807 Phage minor tail protein; Region: Phage_min_tail; pfam05939 693444007808 Phage-related minor tail protein [Function unknown]; Region: COG5281 693444007809 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 693444007810 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 693444007811 Phage related hypothetical protein (DUF1799); Region: DUF1799; pfam08809 693444007812 Domain of unknown function (DUF1789); Region: DUF1789; pfam08748 693444007813 Phage tail protein; Region: Phage_tail_3; pfam08813 693444007814 Bacteriophage related domain of unknown function; Region: DUF4128; pfam13554 693444007815 type III secretion apparatus H+-transporting two-sector ATPase; Region: III_secr_ATP; TIGR02546 693444007816 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 693444007817 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 693444007818 Domain of unknown function (DUF4055); Region: DUF4055; pfam13264 693444007819 Phage terminase large subunit; Region: Terminase_3; cl12054 693444007820 Terminase-like family; Region: Terminase_6; pfam03237 693444007821 Terminase small subunit; Region: Terminase_2; cl01513 693444007822 Terminase small subunit; Region: Terminase_2; pfam03592 693444007823 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 693444007824 The lysozyme from bacteriophage lambda hydrolyses the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc), as do other lysozymes. But unlike other lysozymes, bacteriophage lambda does not produce a reducing...; Region: bacteriophage_lambda_lysozyme; cd00736 693444007825 N-acetyl-D-glucosamine binding site [chemical binding]; other site 693444007826 catalytic residue [active] 693444007827 Phage holin family (Lysis protein S); Region: Phage_holin_3; pfam05106 693444007828 Phage antitermination protein Q; Region: Phage_antiter_Q; pfam06323 693444007829 endodeoxyribonuclease RUS; Reviewed; Region: PRK09786 693444007830 Protein of unknown function (DUF1364); Region: DUF1364; pfam07102 693444007831 hypothetical protein; Provisional; Region: PRK09741 693444007832 CHASE3 domain; Region: CHASE3; cl05000 693444007833 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 693444007834 dimerization interface [polypeptide binding]; other site 693444007835 GAF domain; Region: GAF_3; pfam13492 693444007836 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 693444007837 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693444007838 metal binding site [ion binding]; metal-binding site 693444007839 active site 693444007840 I-site; other site 693444007841 Phenolic acid decarboxylase (PAD); Region: PA_decarbox; cl01382 693444007842 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 693444007843 Protein of unknown function (DUF2582); Region: DUF2582; pfam10771 693444007844 Replication protein P; Region: Phage_lambda_P; pfam06992 693444007845 Bacteriophage replication protein O; Region: Phage_rep_O; pfam04492 693444007846 Uncharacterized protein conserved in bacteria, prophage-related [Function unknown]; Region: COG4197 693444007847 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 693444007848 non-specific DNA binding site [nucleotide binding]; other site 693444007849 Predicted transcriptional regulator [Transcription]; Region: COG2932 693444007850 salt bridge; other site 693444007851 sequence-specific DNA binding site [nucleotide binding]; other site 693444007852 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 693444007853 Catalytic site [active] 693444007854 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 693444007855 FtsZ inhibitor protein; Reviewed; Region: kil; PRK11354 693444007856 Host-nuclease inhibitor protein Gam; Region: Gam; pfam06064 693444007857 RecT family; Region: RecT; pfam03837 693444007858 YqaJ-like viral recombinase domain; Region: YqaJ; pfam09588 693444007859 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 693444007860 DNA N-6-adenine-methyltransferase (Dam); Region: Dam; pfam05869 693444007861 integrase; Provisional; Region: PRK09692 693444007862 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 693444007863 active site 693444007864 Int/Topo IB signature motif; other site 693444007865 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 693444007866 YniB-like protein; Region: YniB; pfam14002 693444007867 2-deoxyglucose-6-phosphatase; Provisional; Region: PRK10826 693444007868 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 693444007869 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 693444007870 motif II; other site 693444007871 2-deoxy-D-gluconate 3-dehydrogenase; Validated; Region: PRK08993 693444007872 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 693444007873 NADP binding site [chemical binding]; other site 693444007874 homodimer interface [polypeptide binding]; other site 693444007875 active site 693444007876 inner membrane protein; Provisional; Region: PRK11648 693444007877 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 693444007878 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 693444007879 cell division modulator; Provisional; Region: PRK10113 693444007880 hydroperoxidase II; Provisional; Region: katE; PRK11249 693444007881 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 693444007882 tetramer interface [polypeptide binding]; other site 693444007883 heme binding pocket [chemical binding]; other site 693444007884 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 693444007885 domain interactions; other site 693444007886 Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803 693444007887 putative active site [active] 693444007888 YdjC motif; other site 693444007889 Mg binding site [ion binding]; other site 693444007890 putative homodimer interface [polypeptide binding]; other site 693444007891 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 693444007892 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 693444007893 NAD binding site [chemical binding]; other site 693444007894 sugar binding site [chemical binding]; other site 693444007895 divalent metal binding site [ion binding]; other site 693444007896 tetramer (dimer of dimers) interface [polypeptide binding]; other site 693444007897 dimer interface [polypeptide binding]; other site 693444007898 DNA-binding transcriptional regulator ChbR; Provisional; Region: PRK10296 693444007899 Cupin domain; Region: Cupin_2; pfam07883 693444007900 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 693444007901 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 693444007902 methionine cluster; other site 693444007903 active site 693444007904 phosphorylation site [posttranslational modification] 693444007905 metal binding site [ion binding]; metal-binding site 693444007906 PTS system N,N'-diacetylchitobiose-specific transporter subunit IIC; Provisional; Region: PRK10297 693444007907 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 693444007908 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 693444007909 active site 693444007910 P-loop; other site 693444007911 phosphorylation site [posttranslational modification] 693444007912 DNA-binding transcriptional activator OsmE; Provisional; Region: PRK11251 693444007913 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 693444007914 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 693444007915 homodimer interface [polypeptide binding]; other site 693444007916 NAD binding pocket [chemical binding]; other site 693444007917 ATP binding pocket [chemical binding]; other site 693444007918 Mg binding site [ion binding]; other site 693444007919 active-site loop [active] 693444007920 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 693444007921 dimer interface [polypeptide binding]; other site 693444007922 Peptidase M14 Succinylglutamate desuccinylase (ASTE) subfamily; Region: M14_ASTE; cd03855 693444007923 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 693444007924 putative active site [active] 693444007925 Zn binding site [ion binding]; other site 693444007926 succinylarginine dihydrolase; Provisional; Region: PRK13281 693444007927 succinylglutamic semialdehyde dehydrogenase; Reviewed; Region: astD; PRK09457 693444007928 N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095 693444007929 NAD(P) binding site [chemical binding]; other site 693444007930 catalytic residues [active] 693444007931 arginine succinyltransferase; Provisional; Region: PRK10456 693444007932 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 693444007933 bifunctional succinylornithine transaminase/acetylornithine transaminase; Provisional; Region: PRK12381 693444007934 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 693444007935 inhibitor-cofactor binding pocket; inhibition site 693444007936 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693444007937 catalytic residue [active] 693444007938 Hok/gef family; Region: HOK_GEF; pfam01848 693444007939 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 693444007940 putative catalytic site [active] 693444007941 putative phosphate binding site [ion binding]; other site 693444007942 active site 693444007943 metal binding site A [ion binding]; metal-binding site 693444007944 DNA binding site [nucleotide binding] 693444007945 putative AP binding site [nucleotide binding]; other site 693444007946 putative metal binding site B [ion binding]; other site 693444007947 Uncharacterized conserved protein [Function unknown]; Region: COG0398 693444007948 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 693444007949 Uncharacterized conserved protein [Function unknown]; Region: COG0398 693444007950 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 693444007951 hypothetical protein; Provisional; Region: PRK11622 693444007952 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4134 693444007953 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4135 693444007954 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693444007955 ABC-ATPase subunit interface; other site 693444007956 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4136 693444007957 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693444007958 Walker A/P-loop; other site 693444007959 ATP binding site [chemical binding]; other site 693444007960 Q-loop/lid; other site 693444007961 ABC transporter signature motif; other site 693444007962 Walker B; other site 693444007963 D-loop; other site 693444007964 H-loop/switch region; other site 693444007965 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 693444007966 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 693444007967 active site residue [active] 693444007968 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 693444007969 active site residue [active] 693444007970 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 693444007971 Uncharacterized conserved protein [Function unknown]; Region: COG2128 693444007972 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 693444007973 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 693444007974 active site 693444007975 8-oxo-dGMP binding site [chemical binding]; other site 693444007976 nudix motif; other site 693444007977 metal binding site [ion binding]; metal-binding site 693444007978 Protein of unknown function (DUF1496); Region: DUF1496; pfam07383 693444007979 glutamate dehydrogenase; Provisional; Region: PRK09414 693444007980 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 693444007981 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 693444007982 NAD(P) binding site [chemical binding]; other site 693444007983 Protein of unknown function (DUF1266); Region: DUF1266; cl14673 693444007984 DNA topoisomerase III; Provisional; Region: PRK07726 693444007985 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 693444007986 active site 693444007987 putative interdomain interaction site [polypeptide binding]; other site 693444007988 putative metal-binding site [ion binding]; other site 693444007989 putative nucleotide binding site [chemical binding]; other site 693444007990 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 693444007991 domain I; other site 693444007992 DNA binding groove [nucleotide binding] 693444007993 phosphate binding site [ion binding]; other site 693444007994 domain II; other site 693444007995 domain III; other site 693444007996 nucleotide binding site [chemical binding]; other site 693444007997 catalytic site [active] 693444007998 domain IV; other site 693444007999 selenophosphate synthetase; Provisional; Region: PRK00943 693444008000 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 693444008001 dimerization interface [polypeptide binding]; other site 693444008002 putative ATP binding site [chemical binding]; other site 693444008003 PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397 693444008004 active site 693444008005 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 693444008006 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 693444008007 putative FMN binding site [chemical binding]; other site 693444008008 protease 4; Provisional; Region: PRK10949 693444008009 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 693444008010 tandem repeat interface [polypeptide binding]; other site 693444008011 oligomer interface [polypeptide binding]; other site 693444008012 active site residues [active] 693444008013 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_1; cd07019 693444008014 tandem repeat interface [polypeptide binding]; other site 693444008015 oligomer interface [polypeptide binding]; other site 693444008016 active site residues [active] 693444008017 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 693444008018 active site 693444008019 homodimer interface [polypeptide binding]; other site 693444008020 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 693444008021 Isochorismatase family; Region: Isochorismatase; pfam00857 693444008022 catalytic triad [active] 693444008023 metal binding site [ion binding]; metal-binding site 693444008024 conserved cis-peptide bond; other site 693444008025 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 693444008026 Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163 693444008027 Flavin binding site [chemical binding]; other site 693444008028 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693444008029 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 693444008030 putative substrate translocation pore; other site 693444008031 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693444008032 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 693444008033 NLPA lipoprotein; Region: Lipoprotein_9; cl17547 693444008034 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693444008035 dimer interface [polypeptide binding]; other site 693444008036 conserved gate region; other site 693444008037 ABC-ATPase subunit interface; other site 693444008038 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 693444008039 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 693444008040 Walker A/P-loop; other site 693444008041 ATP binding site [chemical binding]; other site 693444008042 Q-loop/lid; other site 693444008043 ABC transporter signature motif; other site 693444008044 Walker B; other site 693444008045 D-loop; other site 693444008046 H-loop/switch region; other site 693444008047 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 693444008048 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 693444008049 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 693444008050 active site 693444008051 non-prolyl cis peptide bond; other site 693444008052 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 693444008053 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 693444008054 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 693444008055 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 693444008056 active site 693444008057 dimer interface [polypeptide binding]; other site 693444008058 non-prolyl cis peptide bond; other site 693444008059 insertion regions; other site 693444008060 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693444008061 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 693444008062 Walker A motif; other site 693444008063 ATP binding site [chemical binding]; other site 693444008064 Walker B motif; other site 693444008065 arginine finger; other site 693444008066 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 693444008067 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 693444008068 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 693444008069 substrate binding pocket [chemical binding]; other site 693444008070 membrane-bound complex binding site; other site 693444008071 hinge residues; other site 693444008072 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3139 693444008073 methionine sulfoxide reductase B; Provisional; Region: PRK00222 693444008074 SelR domain; Region: SelR; pfam01641 693444008075 glyceraldehyde-3-phosphate dehydrogenase A; Provisional; Region: gapA; PRK15425 693444008076 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 693444008077 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 693444008078 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 693444008079 active site 693444008080 phosphate binding residues; other site 693444008081 catalytic residues [active] 693444008082 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 693444008083 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 693444008084 active site 693444008085 catalytic tetrad [active] 693444008086 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 693444008087 PrkA family serine protein kinase; Provisional; Region: PRK15455 693444008088 AAA ATPase domain; Region: AAA_16; pfam13191 693444008089 Walker A motif; other site 693444008090 ATP binding site [chemical binding]; other site 693444008091 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 693444008092 hypothetical protein; Provisional; Region: PRK05325 693444008093 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 693444008094 Ligand Binding Site [chemical binding]; other site 693444008095 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 693444008096 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693444008097 metal binding site [ion binding]; metal-binding site 693444008098 active site 693444008099 I-site; other site 693444008100 YeaK is an uncharacterized Echerichia coli protein with a YbaK-like domain of unknown function. The YbaK-like domain family includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting...; Region: YeaK; cd04336 693444008101 putative deacylase active site [active] 693444008102 Predicted membrane protein [Function unknown]; Region: COG2707 693444008103 Cupin domain; Region: Cupin_2; cl17218 693444008104 Helix-turn-helix domain; Region: HTH_18; pfam12833 693444008105 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 693444008106 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 693444008107 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693444008108 putative substrate translocation pore; other site 693444008109 hypothetical protein; Validated; Region: PRK06186 693444008110 conserved cys residue [active] 693444008111 Uncharacterized conserved protein [Function unknown]; Region: COG3189 693444008112 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 693444008113 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 693444008114 Domain of unknown function (DUF333); Region: DUF333; pfam03891 693444008115 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 693444008116 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 693444008117 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 693444008118 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693444008119 metal binding site [ion binding]; metal-binding site 693444008120 active site 693444008121 I-site; other site 693444008122 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 693444008123 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693444008124 metal binding site [ion binding]; metal-binding site 693444008125 active site 693444008126 I-site; other site 693444008127 Protein of unknown function (DUF2534); Region: DUF2534; pfam10749 693444008128 Domain of unknown function (DUF1971); Region: DUF1971; cl17717 693444008129 Uncharacterized protein/domain, possibly involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TehB; COG3615 693444008130 Domain of unknown function (DUF1869); Region: DUF1869; pfam08956 693444008131 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 693444008132 structural tetrad; other site 693444008133 PQQ-like domain; Region: PQQ_2; pfam13360 693444008134 ferric-rhodotorulic acid outer membrane transporter; Provisional; Region: PRK10003 693444008135 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 693444008136 N-terminal plug; other site 693444008137 ligand-binding site [chemical binding]; other site 693444008138 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 693444008139 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693444008140 putative substrate translocation pore; other site 693444008141 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 693444008142 trimer interface [polypeptide binding]; other site 693444008143 active site 693444008144 substrate binding site [chemical binding]; other site 693444008145 CoA binding site [chemical binding]; other site 693444008146 isocitrate dehydrogenase; Validated; Region: PRK07362 693444008147 isocitrate dehydrogenase; Reviewed; Region: PRK07006 693444008148 23S rRNA pseudouridine synthase E; Provisional; Region: PRK11394 693444008149 Pseudouridine synthase, Escherichia coli RluE; Region: PseudoU_synth_RluE; cd02566 693444008150 probable active site [active] 693444008151 Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675 693444008152 nudix motif; other site 693444008153 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 693444008154 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Region: trmU; TIGR00420 693444008155 putative lysogenization regulator; Reviewed; Region: PRK00218 693444008156 adenylosuccinate lyase; Provisional; Region: PRK09285 693444008157 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 693444008158 tetramer interface [polypeptide binding]; other site 693444008159 active site 693444008160 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 693444008161 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 693444008162 DNA-binding transcriptional regulator PhoP; Provisional; Region: PRK10816 693444008163 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693444008164 active site 693444008165 phosphorylation site [posttranslational modification] 693444008166 intermolecular recognition site; other site 693444008167 dimerization interface [polypeptide binding]; other site 693444008168 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 693444008169 DNA binding site [nucleotide binding] 693444008170 sensor protein PhoQ; Provisional; Region: PRK10815 693444008171 PhoQ Sensor; Region: PhoQ_Sensor; pfam08918 693444008172 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 693444008173 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693444008174 ATP binding site [chemical binding]; other site 693444008175 Mg2+ binding site [ion binding]; other site 693444008176 G-X-G motif; other site 693444008177 Uncharacterized conserved protein [Function unknown]; Region: COG2850 693444008178 Di- and tripeptidases [Amino acid transport and metabolism]; Region: PepD; COG2195 693444008179 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 693444008180 metal binding site [ion binding]; metal-binding site 693444008181 dimer interface [polypeptide binding]; other site 693444008182 putrescine/spermidine ABC transporter ATPase protein; Reviewed; Region: potA; PRK09452 693444008183 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693444008184 Walker A/P-loop; other site 693444008185 ATP binding site [chemical binding]; other site 693444008186 Q-loop/lid; other site 693444008187 ABC transporter signature motif; other site 693444008188 Walker B; other site 693444008189 D-loop; other site 693444008190 H-loop/switch region; other site 693444008191 TOBE domain; Region: TOBE_2; pfam08402 693444008192 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693444008193 dimer interface [polypeptide binding]; other site 693444008194 conserved gate region; other site 693444008195 putative PBP binding loops; other site 693444008196 ABC-ATPase subunit interface; other site 693444008197 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 693444008198 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693444008199 dimer interface [polypeptide binding]; other site 693444008200 conserved gate region; other site 693444008201 putative PBP binding loops; other site 693444008202 ABC-ATPase subunit interface; other site 693444008203 spermidine/putrescine ABC transporter periplasmic substrate-binding protein; Reviewed; Region: potD; PRK09501 693444008204 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 693444008205 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 693444008206 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 693444008207 DNA-binding site [nucleotide binding]; DNA binding site 693444008208 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 693444008209 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 693444008210 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 693444008211 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 693444008212 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 693444008213 NAD-dependent deacetylase; Provisional; Region: PRK00481 693444008214 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 693444008215 NAD+ binding site [chemical binding]; other site 693444008216 substrate binding site [chemical binding]; other site 693444008217 Zn binding site [ion binding]; other site 693444008218 fructokinase; Reviewed; Region: PRK09557 693444008219 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 693444008220 nucleotide binding site [chemical binding]; other site 693444008221 outer membrane-specific lipoprotein transporter subunit LolE; Provisional; Region: PRK11146 693444008222 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 693444008223 FtsX-like permease family; Region: FtsX; pfam02687 693444008224 lipoprotein transporter ATP-binding subunit; Provisional; Region: lolD; PRK11629 693444008225 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 693444008226 Walker A/P-loop; other site 693444008227 ATP binding site [chemical binding]; other site 693444008228 Q-loop/lid; other site 693444008229 ABC transporter signature motif; other site 693444008230 Walker B; other site 693444008231 D-loop; other site 693444008232 H-loop/switch region; other site 693444008233 outer membrane-specific lipoprotein transporter subunit LolC; Provisional; Region: PRK10814 693444008234 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 693444008235 FtsX-like permease family; Region: FtsX; pfam02687 693444008236 Predicted membrane protein [Function unknown]; Region: COG4763 693444008237 Acyltransferase family; Region: Acyl_transf_3; pfam01757 693444008238 transcription-repair coupling factor; Provisional; Region: PRK10689 693444008239 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 693444008240 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 693444008241 ATP binding site [chemical binding]; other site 693444008242 putative Mg++ binding site [ion binding]; other site 693444008243 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 693444008244 nucleotide binding region [chemical binding]; other site 693444008245 ATP-binding site [chemical binding]; other site 693444008246 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 693444008247 PTS system glucose-specific transporter subunits IIBC; Provisional; Region: PRK11089 693444008248 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 693444008249 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 693444008250 active site turn [active] 693444008251 phosphorylation site [posttranslational modification] 693444008252 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 693444008253 active site 693444008254 DNA polymerase III subunit delta'; Validated; Region: PRK07993 693444008255 DNA polymerase III subunit delta'; Validated; Region: PRK08485 693444008256 DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115 693444008257 thymidylate kinase; Validated; Region: tmk; PRK00698 693444008258 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 693444008259 TMP-binding site; other site 693444008260 ATP-binding site [chemical binding]; other site 693444008261 conserved hypothetical protein, YceG family; Region: TIGR00247 693444008262 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 693444008263 dimerization interface [polypeptide binding]; other site 693444008264 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 693444008265 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 693444008266 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693444008267 catalytic residue [active] 693444008268 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 693444008269 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 693444008270 dimer interface [polypeptide binding]; other site 693444008271 active site 693444008272 acyl carrier protein; Provisional; Region: acpP; PRK00982 693444008273 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 693444008274 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 693444008275 NAD(P) binding site [chemical binding]; other site 693444008276 homotetramer interface [polypeptide binding]; other site 693444008277 homodimer interface [polypeptide binding]; other site 693444008278 active site 693444008279 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 693444008280 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 693444008281 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 693444008282 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 693444008283 dimer interface [polypeptide binding]; other site 693444008284 active site 693444008285 CoA binding pocket [chemical binding]; other site 693444008286 putative phosphate acyltransferase; Provisional; Region: PRK05331 693444008287 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 693444008288 hypothetical protein; Provisional; Region: PRK11193 693444008289 Maf-like protein; Region: Maf; pfam02545 693444008290 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 693444008291 active site 693444008292 dimer interface [polypeptide binding]; other site 693444008293 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 693444008294 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 693444008295 RNA binding surface [nucleotide binding]; other site 693444008296 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 693444008297 active site 693444008298 RNase E 5' UTR element; D782_2660; IMG reference gene:2507517356 693444008299 Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530 693444008300 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 693444008301 homodimer interface [polypeptide binding]; other site 693444008302 oligonucleotide binding site [chemical binding]; other site 693444008303 Polyribonucleotide phosphorylase C terminal; Region: PNPase_C; pfam12111 693444008304 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693444008305 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693444008306 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 693444008307 putative effector binding pocket; other site 693444008308 dimerization interface [polypeptide binding]; other site 693444008309 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 693444008310 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693444008311 putative substrate translocation pore; other site 693444008312 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08027 693444008313 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 693444008314 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK08147 693444008315 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 693444008316 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 693444008317 flagellar rod assembly protein/muramidase FlgJ; Validated; Region: flgJ; PRK05684 693444008318 Rod binding protein [Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3951 693444008319 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 693444008320 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 693444008321 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 693444008322 Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063 693444008323 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 693444008324 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 693444008325 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 693444008326 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 693444008327 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgF; COG4787 693444008328 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 693444008329 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 693444008330 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 693444008331 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 693444008332 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 693444008333 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 693444008334 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655 693444008335 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 693444008336 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 693444008337 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 693444008338 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 693444008339 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 693444008340 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 693444008341 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 693444008342 Flagellar basal body P-ring biosynthesis protein [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FlgA; COG1261 693444008343 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 693444008344 anti-sigma28 factor FlgM; Provisional; Region: PRK10810 693444008345 FlgN protein; Region: FlgN; cl09176 693444008346 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 693444008347 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 693444008348 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 693444008349 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 693444008350 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 693444008351 hypothetical protein; Provisional; Region: PRK11239 693444008352 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3132 693444008353 ribosomal-protein-S5-alanine N-acetyltransferase; Provisional; Region: PRK10809 693444008354 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 693444008355 multidrug resistance protein MdtH; Provisional; Region: PRK11646 693444008356 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693444008357 putative substrate translocation pore; other site 693444008358 lipoprotein; Provisional; Region: PRK10598 693444008359 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 693444008360 active site 693444008361 substrate binding pocket [chemical binding]; other site 693444008362 dimer interface [polypeptide binding]; other site 693444008363 DNA damage-inducible protein I; Provisional; Region: PRK10597 693444008364 biofilm formation regulatory protein BssS; Reviewed; Region: bssS; PRK12301 693444008365 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 693444008366 hydroxyglutarate oxidase; Provisional; Region: PRK11728 693444008367 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 693444008368 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 693444008369 active site residue [active] 693444008370 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 693444008371 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 693444008372 putative acyl-acceptor binding pocket; other site 693444008373 drug efflux system protein MdtG; Provisional; Region: PRK09874 693444008374 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693444008375 putative substrate translocation pore; other site 693444008376 secY/secA suppressor protein; Provisional; Region: PRK11467 693444008377 lipoprotein; Provisional; Region: PRK10175 693444008378 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 693444008379 Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191 693444008380 Ligand binding site; other site 693444008381 DXD motif; other site 693444008382 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 693444008383 Periplasmic glucan biosynthesis protein, MdoG; Region: MdoG; pfam04349 693444008384 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 693444008385 Acyltransferase family; Region: Acyl_transf_3; pfam01757 693444008386 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 693444008387 putative ADP-ribose binding site [chemical binding]; other site 693444008388 putative active site [active] 693444008389 Fimbrial protein; Region: Fimbrial; cl01416 693444008390 Thin aggregative fimbriae synthesis protein; Region: Tafi-CsgC; cl11667 693444008391 DNA-binding transcriptional regulator CsgD; Provisional; Region: PRK10100 693444008392 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 693444008393 DNA binding residues [nucleotide binding] 693444008394 dimerization interface [polypeptide binding]; other site 693444008395 Curli assembly protein CsgE; Region: CsgE; cl08115 693444008396 Curli production assembly/transport component CsgG; Region: CsgG; cl17434 693444008397 major curlin subunit; Provisional; Region: csgA; PRK10051 693444008398 curlin minor subunit CsgB; Provisional; Region: csgB; PRK10101 693444008399 curlin minor subunit CsgB; Provisional; Region: csgB; PRK10101 693444008400 Type VIII secretion system (T8SS), CsgF protein; Region: CsgF; cl08082 693444008401 Protein of unknown function (DUF1097); Region: DUF1097; pfam06496 693444008402 Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381 693444008403 putative hydrolase; Validated; Region: PRK09248 693444008404 Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437 693444008405 active site 693444008406 bifunctional glyoxylate/hydroxypyruvate reductase A; Provisional; Region: ghrA; PRK15469 693444008407 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 693444008408 putative ligand binding site [chemical binding]; other site 693444008409 NAD binding site [chemical binding]; other site 693444008410 dimerization interface [polypeptide binding]; other site 693444008411 catalytic site [active] 693444008412 LysR family transcriptional regulator; Provisional; Region: PRK14997 693444008413 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693444008414 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473 693444008415 putative effector binding pocket; other site 693444008416 putative dimerization interface [polypeptide binding]; other site 693444008417 Pirin-related protein [General function prediction only]; Region: COG1741 693444008418 Pirin; Region: Pirin; pfam02678 693444008419 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 693444008420 Isochorismatase family; Region: Isochorismatase; pfam00857 693444008421 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 693444008422 catalytic triad [active] 693444008423 dimer interface [polypeptide binding]; other site 693444008424 conserved cis-peptide bond; other site 693444008425 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 693444008426 hypothetical protein; Provisional; Region: PRK10536 693444008427 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 693444008428 Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837 693444008429 inactive ferrous ion transporter periplasmic protein EfeO; Provisional; Region: PRK10378 693444008430 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 693444008431 Imelysin; Region: Peptidase_M75; pfam09375 693444008432 FTR1 family protein; Region: TIGR00145 693444008433 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 693444008434 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 693444008435 Na binding site [ion binding]; other site 693444008436 trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: putA; PRK11809 693444008437 Predicted transcriptional regulator [Transcription]; Region: COG3905 693444008438 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 693444008439 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 693444008440 Glutamate binding site [chemical binding]; other site 693444008441 NAD binding site [chemical binding]; other site 693444008442 catalytic residues [active] 693444008443 hypothetical protein; Validated; Region: PRK06778 693444008444 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 693444008445 ligand binding site [chemical binding]; other site 693444008446 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; COG1298 693444008447 FHIPEP family; Region: FHIPEP; pfam00771 693444008448 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: HicB; COG4226 693444008449 HicB family; Region: HicB; pfam05534 693444008450 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 693444008451 NlpC/P60 family; Region: NLPC_P60; pfam00877 693444008452 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134 693444008453 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 693444008454 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3755 693444008455 HTH-type transcriptional regulator RutR; Provisional; Region: PRK15008 693444008456 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 693444008457 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 693444008458 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 693444008459 EamA-like transporter family; Region: EamA; pfam00892 693444008460 General stress protein [General function prediction only]; Region: GsiB; COG3729 693444008461 lysine decarboxylase CadA; Provisional; Region: PRK15400 693444008462 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 693444008463 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 693444008464 homodimer interface [polypeptide binding]; other site 693444008465 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693444008466 catalytic residue [active] 693444008467 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 693444008468 putrescine transporter; Provisional; Region: potE; PRK10655 693444008469 Winged helix-turn-helix DNA-binding; Region: HTH_35; cl17423 693444008470 Helix-turn-helix; Region: HTH_3; pfam01381 693444008471 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 693444008472 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 693444008473 dimer interface [polypeptide binding]; other site 693444008474 putative anticodon binding site; other site 693444008475 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 693444008476 motif 1; other site 693444008477 active site 693444008478 motif 2; other site 693444008479 motif 3; other site 693444008480 NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767 693444008481 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 693444008482 hypothetical protein; Provisional; Region: PRK10174 693444008483 glucose-1-phosphatase/inositol phosphatase; Provisional; Region: PRK10173 693444008484 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 693444008485 catalytic core [active] 693444008486 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 693444008487 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693444008488 dimer interface [polypeptide binding]; other site 693444008489 conserved gate region; other site 693444008490 putative PBP binding loops; other site 693444008491 ABC-ATPase subunit interface; other site 693444008492 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693444008493 dimer interface [polypeptide binding]; other site 693444008494 conserved gate region; other site 693444008495 putative PBP binding loops; other site 693444008496 ABC-ATPase subunit interface; other site 693444008497 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 693444008498 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 693444008499 Walker A/P-loop; other site 693444008500 ATP binding site [chemical binding]; other site 693444008501 Q-loop/lid; other site 693444008502 ABC transporter signature motif; other site 693444008503 Walker B; other site 693444008504 D-loop; other site 693444008505 H-loop/switch region; other site 693444008506 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 693444008507 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 693444008508 substrate binding pocket [chemical binding]; other site 693444008509 membrane-bound complex binding site; other site 693444008510 hinge residues; other site 693444008511 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 693444008512 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 693444008513 Walker A/P-loop; other site 693444008514 ATP binding site [chemical binding]; other site 693444008515 Q-loop/lid; other site 693444008516 ABC transporter signature motif; other site 693444008517 Walker B; other site 693444008518 D-loop; other site 693444008519 H-loop/switch region; other site 693444008520 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 693444008521 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 693444008522 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 693444008523 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693444008524 dimer interface [polypeptide binding]; other site 693444008525 conserved gate region; other site 693444008526 ABC-ATPase subunit interface; other site 693444008527 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 693444008528 Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163 693444008529 Flavin binding site [chemical binding]; other site 693444008530 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 693444008531 Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163 693444008532 Flavin binding site [chemical binding]; other site 693444008533 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 693444008534 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 693444008535 active site 693444008536 non-prolyl cis peptide bond; other site 693444008537 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 693444008538 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 693444008539 Walker A/P-loop; other site 693444008540 ATP binding site [chemical binding]; other site 693444008541 Q-loop/lid; other site 693444008542 ABC transporter signature motif; other site 693444008543 Walker B; other site 693444008544 D-loop; other site 693444008545 H-loop/switch region; other site 693444008546 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 693444008547 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693444008548 dimer interface [polypeptide binding]; other site 693444008549 conserved gate region; other site 693444008550 putative PBP binding loops; other site 693444008551 ABC-ATPase subunit interface; other site 693444008552 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 693444008553 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 693444008554 membrane-bound complex binding site; other site 693444008555 hinge residues; other site 693444008556 DinI-like family; Region: DinI; pfam06183 693444008557 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693444008558 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693444008559 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 693444008560 dimerization interface [polypeptide binding]; other site 693444008561 substrate binding pocket [chemical binding]; other site 693444008562 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 693444008563 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 693444008564 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 693444008565 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 693444008566 Spore Coat Protein U domain; Region: SCPU; pfam05229 693444008567 Spore Coat Protein U domain; Region: SCPU; pfam05229 693444008568 urea carboxylase; Region: urea_carbox; TIGR02712 693444008569 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 693444008570 ATP-grasp domain; Region: ATP-grasp_4; cl17255 693444008571 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 693444008572 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 693444008573 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 693444008574 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 693444008575 carboxyltransferase (CT) interaction site; other site 693444008576 biotinylation site [posttranslational modification]; other site 693444008577 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 693444008578 Domain of unknown function (DUF1989); Region: DUF1989; pfam09347 693444008579 urea carboxylase-associated protein 2; Region: urea_degr_2; TIGR03425 693444008580 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 693444008581 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 693444008582 nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184 693444008583 Walker A/P-loop; other site 693444008584 ATP binding site [chemical binding]; other site 693444008585 Q-loop/lid; other site 693444008586 ABC transporter signature motif; other site 693444008587 Walker B; other site 693444008588 D-loop; other site 693444008589 H-loop/switch region; other site 693444008590 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 693444008591 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693444008592 dimer interface [polypeptide binding]; other site 693444008593 conserved gate region; other site 693444008594 putative PBP binding loops; other site 693444008595 ABC-ATPase subunit interface; other site 693444008596 ABC transporter periplasmic binding protein, urea carboxylase region; Region: ABC_peri_uca; TIGR03427 693444008597 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 693444008598 ykkC-yxkD leader; D782_2768; IMG reference gene:2507517464 693444008599 Uncharacterized conserved protein [Function unknown]; Region: COG1359 693444008600 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 693444008601 Ligand Binding Site [chemical binding]; other site 693444008602 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 693444008603 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 693444008604 Walker A/P-loop; other site 693444008605 ATP binding site [chemical binding]; other site 693444008606 Q-loop/lid; other site 693444008607 ABC transporter signature motif; other site 693444008608 Walker B; other site 693444008609 D-loop; other site 693444008610 H-loop/switch region; other site 693444008611 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 693444008612 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693444008613 dimer interface [polypeptide binding]; other site 693444008614 conserved gate region; other site 693444008615 putative PBP binding loops; other site 693444008616 ABC-ATPase subunit interface; other site 693444008617 ABC-type taurine transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: TauA; COG4521 693444008618 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 693444008619 substrate binding pocket [chemical binding]; other site 693444008620 membrane-bound complex binding site; other site 693444008621 aspartate racemase; Region: asp_race; TIGR00035 693444008622 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 693444008623 D-cysteine desulfhydrase; Validated; Region: PRK03910 693444008624 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 693444008625 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 693444008626 catalytic residue [active] 693444008627 4-aminobutyrate transaminase; Provisional; Region: PRK09792 693444008628 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 693444008629 inhibitor-cofactor binding pocket; inhibition site 693444008630 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693444008631 catalytic residue [active] 693444008632 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 693444008633 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 693444008634 gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK09847 693444008635 Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112 693444008636 NAD(P) binding site [chemical binding]; other site 693444008637 catalytic residues [active] 693444008638 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 693444008639 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 693444008640 non-specific DNA binding site [nucleotide binding]; other site 693444008641 salt bridge; other site 693444008642 sequence-specific DNA binding site [nucleotide binding]; other site 693444008643 Cupin domain; Region: Cupin_2; pfam07883 693444008644 gamma-glutamyl-gamma-aminobutyrate hydrolase; Provisional; Region: puuD; PRK11366 693444008645 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 693444008646 catalytic triad [active] 693444008647 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 693444008648 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 693444008649 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 693444008650 Pirin-related protein [General function prediction only]; Region: COG1741 693444008651 Pirin; Region: Pirin; pfam02678 693444008652 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693444008653 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693444008654 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 693444008655 putative effector binding pocket; other site 693444008656 dimerization interface [polypeptide binding]; other site 693444008657 Protein of unknown function (DUF2543); Region: DUF2543; pfam10820 693444008658 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 693444008659 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 693444008660 YheO-like PAS domain; Region: PAS_6; pfam08348 693444008661 HTH domain; Region: HTH_22; pfam13309 693444008662 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 693444008663 homotrimer interaction site [polypeptide binding]; other site 693444008664 putative active site [active] 693444008665 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 693444008666 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 693444008667 active site 693444008668 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 693444008669 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 693444008670 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 693444008671 Autotransporter beta-domain; Region: Autotransporter; pfam03797 693444008672 hypothetical protein; Provisional; Region: PRK13687 693444008673 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 693444008674 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693444008675 S-adenosylmethionine binding site [chemical binding]; other site 693444008676 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cd00250 693444008677 substrate binding pocket [chemical binding]; other site 693444008678 active site 693444008679 iron coordination sites [ion binding]; other site 693444008680 Predicted dehydrogenase [General function prediction only]; Region: COG0579 693444008681 hydroxyglutarate oxidase; Provisional; Region: PRK11728 693444008682 succinate-semialdehyde dehydrogenase I; Provisional; Region: gabD; PRK11241 693444008683 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 693444008684 tetramerization interface [polypeptide binding]; other site 693444008685 NAD(P) binding site [chemical binding]; other site 693444008686 catalytic residues [active] 693444008687 4-aminobutyrate aminotransferase; Validated; Region: PRK08088 693444008688 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 693444008689 inhibitor-cofactor binding pocket; inhibition site 693444008690 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693444008691 catalytic residue [active] 693444008692 gamma-aminobutyrate transporter; Provisional; Region: PRK10197 693444008693 DNA-binding transcriptional regulator CsiR; Provisional; Region: PRK11534 693444008694 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 693444008695 DNA-binding site [nucleotide binding]; DNA binding site 693444008696 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 693444008697 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693444008698 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693444008699 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 693444008700 putative effector binding pocket; other site 693444008701 putative dimerization interface [polypeptide binding]; other site 693444008702 Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180 693444008703 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 693444008704 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 693444008705 Uncharacterized protein, 4-oxalocrotonate tautomerase homolog [General function prediction only]; Region: COG1942 693444008706 active site 1 [active] 693444008707 dimer interface [polypeptide binding]; other site 693444008708 hexamer interface [polypeptide binding]; other site 693444008709 active site 2 [active] 693444008710 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693444008711 Major Facilitator Superfamily; Region: MFS_1; pfam07690 693444008712 putative substrate translocation pore; other site 693444008713 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693444008714 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693444008715 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 693444008716 dimerization interface [polypeptide binding]; other site 693444008717 Domain of unknown function DUF20; Region: UPF0118; pfam01594 693444008718 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 693444008719 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 693444008720 active site 693444008721 homotetramer interface [polypeptide binding]; other site 693444008722 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 693444008723 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 693444008724 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 693444008725 catalytic triad [active] 693444008726 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 693444008727 Helix-turn-helix domain; Region: HTH_18; pfam12833 693444008728 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 693444008729 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693444008730 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693444008731 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 693444008732 putative effector binding pocket; other site 693444008733 dimerization interface [polypeptide binding]; other site 693444008734 Protein of unknown function, DUF606; Region: DUF606; pfam04657 693444008735 Protein of unknown function, DUF606; Region: DUF606; pfam04657 693444008736 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693444008737 putative substrate translocation pore; other site 693444008738 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693444008739 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 693444008740 Glutaminase; Region: Glutaminase; cl00907 693444008741 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 693444008742 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693444008743 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 693444008744 dimerization interface [polypeptide binding]; other site 693444008745 substrate binding pocket [chemical binding]; other site 693444008746 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 693444008747 putative active site pocket [active] 693444008748 dimerization interface [polypeptide binding]; other site 693444008749 putative catalytic residue [active] 693444008750 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693444008751 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693444008752 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 693444008753 putative effector binding pocket; other site 693444008754 dimerization interface [polypeptide binding]; other site 693444008755 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235 693444008756 cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142 693444008757 Uncharacterized protein involved in biosynthesis of c-type cytochromes [Posttranslational modification, protein turnover, chaperones]; Region: CcmH; COG3088 693444008758 periplasmic protein thiol:disulfide oxidoreductases, DsbE subfamily; Region: dsbE; TIGR00385 693444008759 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 693444008760 catalytic residues [active] 693444008761 central insert; other site 693444008762 c-type cytochrome biogenesis protein CcmF; Region: nrfE; TIGR00353 693444008763 CcmE; Region: CcmE; cl00994 693444008764 Heme exporter protein D (CcmD); Region: CcmD; cl11475 693444008765 heme exporter protein CcmC; Region: ccmC; TIGR01191 693444008766 heme exporter protein CcmB; Region: ccmB; TIGR01190 693444008767 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538 693444008768 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693444008769 Walker A/P-loop; other site 693444008770 ATP binding site [chemical binding]; other site 693444008771 Q-loop/lid; other site 693444008772 ABC transporter signature motif; other site 693444008773 Walker B; other site 693444008774 D-loop; other site 693444008775 H-loop/switch region; other site 693444008776 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 693444008777 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 693444008778 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 693444008779 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 693444008780 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 693444008781 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 693444008782 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 693444008783 Predicted membrane protein [Function unknown]; Region: COG2259 693444008784 methionine synthase; Provisional; Region: PRK01207 693444008785 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 693444008786 substrate binding site [chemical binding]; other site 693444008787 THF binding site; other site 693444008788 zinc-binding site [ion binding]; other site 693444008789 Domain of unknown function (DUF1852); Region: DUF1852; pfam08908 693444008790 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 693444008791 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 693444008792 peptide binding site [polypeptide binding]; other site 693444008793 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 693444008794 YccA-like proteins; Region: YccA_like; cd10433 693444008795 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920 693444008796 sulfur transfer protein TusE; Provisional; Region: PRK11508 693444008797 acylphosphatase; Provisional; Region: PRK14426 693444008798 23S rRNA m(5)C1962 methyltransferase; Provisional; Region: PRK15128 693444008799 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 693444008800 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 693444008801 putative RNA binding site [nucleotide binding]; other site 693444008802 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693444008803 S-adenosylmethionine binding site [chemical binding]; other site 693444008804 heat shock protein HspQ; Provisional; Region: PRK14129 693444008805 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693444008806 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693444008807 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 693444008808 putative effector binding pocket; other site 693444008809 putative dimerization interface [polypeptide binding]; other site 693444008810 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 693444008811 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 693444008812 FMN binding site [chemical binding]; other site 693444008813 substrate binding site [chemical binding]; other site 693444008814 putative catalytic residue [active] 693444008815 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 693444008816 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 693444008817 active site 693444008818 dimer interfaces [polypeptide binding]; other site 693444008819 catalytic residues [active] 693444008820 DNA helicase IV; Provisional; Region: helD; PRK11054 693444008821 DNA helicase IV / RNA helicase N terminal; Region: Nucleolin_N; pfam12462 693444008822 Part of AAA domain; Region: AAA_19; pfam13245 693444008823 Family description; Region: UvrD_C_2; pfam13538 693444008824 Predicted membrane protein [Function unknown]; Region: COG3304 693444008825 Domain of unknown function (DUF307); Region: DUF307; pfam03733 693444008826 Domain of unknown function (DUF307); Region: DUF307; pfam03733 693444008827 TIGR01666 family membrane protein; Region: YCCS 693444008828 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 693444008829 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 693444008830 TfoX N-terminal domain; Region: TfoX_N; pfam04993 693444008831 TfoX C-terminal domain; Region: TfoX_C; pfam04994 693444008832 SOS cell division inhibitor; Provisional; Region: PRK10595 693444008833 outer membrane protein A; Reviewed; Region: PRK10808 693444008834 OmpA-like transmembrane domain; Region: OmpA_membrane; pfam01389 693444008835 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 693444008836 ligand binding site [chemical binding]; other site 693444008837 Ter macrodomain organizer matS-binding protein; Provisional; Region: PRK05097 693444008838 Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067 693444008839 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 693444008840 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 693444008841 active site 1 [active] 693444008842 dimer interface [polypeptide binding]; other site 693444008843 active site 2 [active] 693444008844 Ribosome modulation factor; Region: RMF; pfam04957 693444008845 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009 693444008846 Protein of unknown function (DUF330); Region: DUF330; pfam03886 693444008847 paraquat-inducible protein B; Provisional; Region: PRK10807 693444008848 mce related protein; Region: MCE; pfam02470 693444008849 mce related protein; Region: MCE; pfam02470 693444008850 mce related protein; Region: MCE; pfam02470 693444008851 paraquat-inducible membrane protein A; Provisional; Region: PRK15103 693444008852 Paraquat-inducible protein A; Region: PqiA; pfam04403 693444008853 Paraquat-inducible protein A; Region: PqiA; pfam04403 693444008854 ABC transporter ATPase component; Reviewed; Region: PRK11147 693444008855 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693444008856 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693444008857 Walker A/P-loop; other site 693444008858 Walker A/P-loop; other site 693444008859 ATP binding site [chemical binding]; other site 693444008860 ATP binding site [chemical binding]; other site 693444008861 Q-loop/lid; other site 693444008862 Q-loop/lid; other site 693444008863 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 693444008864 ABC transporter signature motif; other site 693444008865 Walker B; other site 693444008866 D-loop; other site 693444008867 ABC transporter; Region: ABC_tran_2; pfam12848 693444008868 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 693444008869 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 693444008870 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 693444008871 Putative RNA methylase family UPF0020; Region: UPF0020; pfam01170 693444008872 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693444008873 S-adenosylmethionine binding site [chemical binding]; other site 693444008874 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 693444008875 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 693444008876 MOSC domain; Region: MOSC; pfam03473 693444008877 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 693444008878 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 693444008879 catalytic loop [active] 693444008880 iron binding site [ion binding]; other site 693444008881 Protein of unknown function (DUF1379); Region: DUF1379; pfam07126 693444008882 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 693444008883 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 693444008884 quinone interaction residues [chemical binding]; other site 693444008885 active site 693444008886 catalytic residues [active] 693444008887 FMN binding site [chemical binding]; other site 693444008888 substrate binding site [chemical binding]; other site 693444008889 putativi pili assembly chaperone; Provisional; Region: PRK11385 693444008890 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 693444008891 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 693444008892 Fimbrial protein; Region: Fimbrial; cl01416 693444008893 Fimbrial protein; Region: Fimbrial; cl01416 693444008894 Fimbrial protein; Region: Fimbrial; cl01416 693444008895 outer membrane usher protein; Provisional; Region: PRK15193 693444008896 PapC N-terminal domain; Region: PapC_N; pfam13954 693444008897 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 693444008898 PapC C-terminal domain; Region: PapC_C; pfam13953 693444008899 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 693444008900 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 693444008901 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 693444008902 Fimbrial protein; Region: Fimbrial; cl01416 693444008903 NAD(P)H-dependent FMN reductase; Provisional; Region: PRK10569 693444008904 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 693444008905 aminopeptidase N; Provisional; Region: pepN; PRK14015 693444008906 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 693444008907 active site 693444008908 Zn binding site [ion binding]; other site 693444008909 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 693444008910 Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401 693444008911 active site 693444008912 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 693444008913 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 693444008914 putative dimer interface [polypeptide binding]; other site 693444008915 putative anticodon binding site; other site 693444008916 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 693444008917 homodimer interface [polypeptide binding]; other site 693444008918 motif 1; other site 693444008919 motif 2; other site 693444008920 active site 693444008921 motif 3; other site 693444008922 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 693444008923 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 693444008924 eyelet of channel; other site 693444008925 trimer interface [polypeptide binding]; other site 693444008926 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 693444008927 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 693444008928 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693444008929 homodimer interface [polypeptide binding]; other site 693444008930 catalytic residue [active] 693444008931 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 693444008932 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 693444008933 Peptidase M15; Region: Peptidase_M15_3; cl01194 693444008934 murein L,D-transpeptidase; Provisional; Region: PRK10594 693444008935 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 693444008936 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 693444008937 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 693444008938 cell division protein MukB; Provisional; Region: mukB; PRK04863 693444008939 P-loop containing region of AAA domain; Region: AAA_29; cl17516 693444008940 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 693444008941 condesin subunit E; Provisional; Region: PRK05256 693444008942 condesin subunit F; Provisional; Region: PRK05260 693444008943 Methyltransferase domain; Region: Methyltransf_31; pfam13847 693444008944 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693444008945 S-adenosylmethionine binding site [chemical binding]; other site 693444008946 Uncharacterized conserved protein [Function unknown]; Region: COG1434 693444008947 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 693444008948 putative active site [active] 693444008949 hypothetical protein; Provisional; Region: PRK10593 693444008950 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 693444008951 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 693444008952 Ligand binding site; other site 693444008953 oligomer interface; other site 693444008954 Trm112p-like protein; Region: Trm112p; cl01066 693444008955 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 693444008956 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 693444008957 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 693444008958 tetraacyldisaccharide 4'-kinase; Region: lpxK; TIGR00682 693444008959 lipid transporter ATP-binding/permease protein; Provisional; Region: PRK11176 693444008960 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 693444008961 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 693444008962 Walker A/P-loop; other site 693444008963 ATP binding site [chemical binding]; other site 693444008964 Q-loop/lid; other site 693444008965 ABC transporter signature motif; other site 693444008966 Walker B; other site 693444008967 D-loop; other site 693444008968 H-loop/switch region; other site 693444008969 ComEC family competence protein; Provisional; Region: PRK11539 693444008970 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 693444008971 Competence protein; Region: Competence; pfam03772 693444008972 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 693444008973 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 693444008974 IHF dimer interface [polypeptide binding]; other site 693444008975 IHF - DNA interface [nucleotide binding]; other site 693444008976 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 693444008977 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 693444008978 RNA binding site [nucleotide binding]; other site 693444008979 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 693444008980 RNA binding site [nucleotide binding]; other site 693444008981 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689 693444008982 RNA binding site [nucleotide binding]; other site 693444008983 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 693444008984 RNA binding site [nucleotide binding]; other site 693444008985 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 693444008986 RNA binding site [nucleotide binding]; other site 693444008987 cytidylate kinase; Provisional; Region: cmk; PRK00023 693444008988 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 693444008989 CMP-binding site; other site 693444008990 The sites determining sugar specificity; other site 693444008991 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 693444008992 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 693444008993 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288 693444008994 putative active site [active] 693444008995 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 693444008996 homodimer interface [polypeptide binding]; other site 693444008997 substrate-cofactor binding pocket; other site 693444008998 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693444008999 catalytic residue [active] 693444009000 Predicted membrane protein [Function unknown]; Region: COG2323 693444009001 uncharacterized domain; Region: TIGR00702 693444009002 YcaO-like family; Region: YcaO; pfam02624 693444009003 formate transporter; Provisional; Region: PRK10805 693444009004 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 693444009005 Pyruvate formate lyase 1; Region: PFL1; cd01678 693444009006 coenzyme A binding site [chemical binding]; other site 693444009007 active site 693444009008 catalytic residues [active] 693444009009 glycine loop; other site 693444009010 pyruvate formate lyase-activating enzyme 1; Provisional; Region: pflA; PRK11145 693444009011 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 693444009012 FeS/SAM binding site; other site 693444009013 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693444009014 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693444009015 LysR substrate binding domain; Region: LysR_substrate; pfam03466 693444009016 dimerization interface [polypeptide binding]; other site 693444009017 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 693444009018 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 693444009019 active site 693444009020 putative MFS family transporter protein; Provisional; Region: PRK03633 693444009021 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693444009022 putative substrate translocation pore; other site 693444009023 DMSO reductase anchor subunit (DmsC); Region: DmsC; pfam04976 693444009024 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 693444009025 4Fe-4S binding domain; Region: Fer4; pfam00037 693444009026 anaerobic dimethyl sulfoxide reductase subunit A; Provisional; Region: PRK14990 693444009027 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 693444009028 putative [Fe4-S4] binding site [ion binding]; other site 693444009029 putative molybdopterin cofactor binding site [chemical binding]; other site 693444009030 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 693444009031 putative molybdopterin cofactor binding site; other site 693444009032 seryl-tRNA synthetase; Provisional; Region: PRK05431 693444009033 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 693444009034 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 693444009035 dimer interface [polypeptide binding]; other site 693444009036 active site 693444009037 motif 1; other site 693444009038 motif 2; other site 693444009039 motif 3; other site 693444009040 recombination factor protein RarA; Reviewed; Region: PRK13342 693444009041 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693444009042 Walker A motif; other site 693444009043 ATP binding site [chemical binding]; other site 693444009044 Walker B motif; other site 693444009045 arginine finger; other site 693444009046 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 693444009047 periplasmic chaperone LolA; Region: lolA; TIGR00547 693444009048 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 693444009049 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 693444009050 DNA translocase FtsK; Provisional; Region: PRK10263 693444009051 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 693444009052 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 693444009053 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 693444009054 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 693444009055 putative DNA binding site [nucleotide binding]; other site 693444009056 putative Zn2+ binding site [ion binding]; other site 693444009057 AsnC family; Region: AsnC_trans_reg; pfam01037 693444009058 thioredoxin reductase; Provisional; Region: PRK10262 693444009059 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 693444009060 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 693444009061 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11174 693444009062 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 693444009063 Alginate O-acetyl transferase AlgF; Region: AlgF; pfam11182 693444009064 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693444009065 Walker A/P-loop; other site 693444009066 ATP binding site [chemical binding]; other site 693444009067 Q-loop/lid; other site 693444009068 ABC transporter signature motif; other site 693444009069 Walker B; other site 693444009070 D-loop; other site 693444009071 H-loop/switch region; other site 693444009072 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160 693444009073 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 693444009074 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693444009075 Walker A/P-loop; other site 693444009076 ATP binding site [chemical binding]; other site 693444009077 Q-loop/lid; other site 693444009078 ABC transporter signature motif; other site 693444009079 Walker B; other site 693444009080 D-loop; other site 693444009081 H-loop/switch region; other site 693444009082 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 693444009083 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 693444009084 rRNA binding site [nucleotide binding]; other site 693444009085 predicted 30S ribosome binding site; other site 693444009086 ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034 693444009087 Clp amino terminal domain; Region: Clp_N; pfam02861 693444009088 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693444009089 Walker A motif; other site 693444009090 ATP binding site [chemical binding]; other site 693444009091 Walker B motif; other site 693444009092 arginine finger; other site 693444009093 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693444009094 Walker A motif; other site 693444009095 ATP binding site [chemical binding]; other site 693444009096 Walker B motif; other site 693444009097 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 693444009098 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 693444009099 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 693444009100 DNA-binding site [nucleotide binding]; DNA binding site 693444009101 RNA-binding motif; other site 693444009102 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 693444009103 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 693444009104 Walker A/P-loop; other site 693444009105 ATP binding site [chemical binding]; other site 693444009106 Q-loop/lid; other site 693444009107 ABC transporter signature motif; other site 693444009108 Walker B; other site 693444009109 D-loop; other site 693444009110 H-loop/switch region; other site 693444009111 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 693444009112 FtsX-like permease family; Region: FtsX; pfam02687 693444009113 macrolide transporter subunit MacA; Provisional; Region: PRK11578 693444009114 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 693444009115 HlyD family secretion protein; Region: HlyD_3; pfam13437 693444009116 Protein of unknown function (DUF535); Region: DUF535; pfam04393 693444009117 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 693444009118 Protein of unknown function (DUF2813); Region: DUF2813; pfam11398 693444009119 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 693444009120 putative active site [active] 693444009121 putative metal-binding site [ion binding]; other site 693444009122 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 693444009123 amphipathic channel; other site 693444009124 Asn-Pro-Ala signature motifs; other site 693444009125 Predicted membrane protein [Function unknown]; Region: COG2431 693444009126 hybrid cluster protein; Provisional; Region: PRK05290 693444009127 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 693444009128 ACS interaction site; other site 693444009129 CODH interaction site; other site 693444009130 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 693444009131 hybrid metal cluster; other site 693444009132 HCP oxidoreductase, NADH-dependent; Provisional; Region: PRK10684 693444009133 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 693444009134 FAD binding pocket [chemical binding]; other site 693444009135 FAD binding motif [chemical binding]; other site 693444009136 phosphate binding motif [ion binding]; other site 693444009137 beta-alpha-beta structure motif; other site 693444009138 NAD binding pocket [chemical binding]; other site 693444009139 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 693444009140 catalytic loop [active] 693444009141 iron binding site [ion binding]; other site 693444009142 pyruvate dehydrogenase; Provisional; Region: PRK09124 693444009143 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 693444009144 PYR/PP interface [polypeptide binding]; other site 693444009145 dimer interface [polypeptide binding]; other site 693444009146 tetramer interface [polypeptide binding]; other site 693444009147 TPP binding site [chemical binding]; other site 693444009148 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 693444009149 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 693444009150 TPP-binding site [chemical binding]; other site 693444009151 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 693444009152 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 693444009153 tetramer interface [polypeptide binding]; other site 693444009154 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693444009155 catalytic residue [active] 693444009156 atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245 693444009157 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 693444009158 putative NAD(P) binding site [chemical binding]; other site 693444009159 putative active site [active] 693444009160 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 693444009161 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 693444009162 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 693444009163 NAD(P) binding site [chemical binding]; other site 693444009164 active site 693444009165 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 693444009166 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 693444009167 amidase catalytic site [active] 693444009168 Zn binding residues [ion binding]; other site 693444009169 substrate binding site [chemical binding]; other site 693444009170 hypothetical protein; Provisional; Region: PRK02877 693444009171 putative lipoprotein; Provisional; Region: PRK10533 693444009172 arginine transporter ATP-binding subunit; Provisional; Region: artP; PRK11124 693444009173 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693444009174 Walker A/P-loop; other site 693444009175 ATP binding site [chemical binding]; other site 693444009176 Q-loop/lid; other site 693444009177 ABC transporter signature motif; other site 693444009178 Walker B; other site 693444009179 D-loop; other site 693444009180 H-loop/switch region; other site 693444009181 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 693444009182 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 693444009183 substrate binding pocket [chemical binding]; other site 693444009184 membrane-bound complex binding site; other site 693444009185 hinge residues; other site 693444009186 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 693444009187 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693444009188 dimer interface [polypeptide binding]; other site 693444009189 conserved gate region; other site 693444009190 putative PBP binding loops; other site 693444009191 ABC-ATPase subunit interface; other site 693444009192 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 693444009193 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693444009194 dimer interface [polypeptide binding]; other site 693444009195 conserved gate region; other site 693444009196 putative PBP binding loops; other site 693444009197 ABC-ATPase subunit interface; other site 693444009198 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 693444009199 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 693444009200 substrate binding pocket [chemical binding]; other site 693444009201 membrane-bound complex binding site; other site 693444009202 hinge residues; other site 693444009203 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 693444009204 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 693444009205 dimer interface [polypeptide binding]; other site 693444009206 phosphorylation site [posttranslational modification] 693444009207 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693444009208 ATP binding site [chemical binding]; other site 693444009209 Mg2+ binding site [ion binding]; other site 693444009210 G-X-G motif; other site 693444009211 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 693444009212 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693444009213 active site 693444009214 phosphorylation site [posttranslational modification] 693444009215 intermolecular recognition site; other site 693444009216 dimerization interface [polypeptide binding]; other site 693444009217 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 693444009218 DNA binding site [nucleotide binding] 693444009219 23S rRNA (uracil-5-)-methyltransferase RumB; Region: meth_trns_rumB; TIGR02085 693444009220 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693444009221 S-adenosylmethionine binding site [chemical binding]; other site 693444009222 Protein of unknown function (DUF2593); Region: DUF2593; pfam10767 693444009223 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 693444009224 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693444009225 dimer interface [polypeptide binding]; other site 693444009226 conserved gate region; other site 693444009227 putative PBP binding loops; other site 693444009228 ABC-ATPase subunit interface; other site 693444009229 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693444009230 dimer interface [polypeptide binding]; other site 693444009231 conserved gate region; other site 693444009232 putative PBP binding loops; other site 693444009233 ABC-ATPase subunit interface; other site 693444009234 putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607 693444009235 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 693444009236 Walker A/P-loop; other site 693444009237 ATP binding site [chemical binding]; other site 693444009238 Q-loop/lid; other site 693444009239 ABC transporter signature motif; other site 693444009240 Walker B; other site 693444009241 D-loop; other site 693444009242 H-loop/switch region; other site 693444009243 TOBE domain; Region: TOBE_2; pfam08402 693444009244 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 693444009245 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 693444009246 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 693444009247 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 693444009248 RimK-like ATP-grasp domain; Region: RimK; pfam08443 693444009249 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 693444009250 dimer interface [polypeptide binding]; other site 693444009251 FMN binding site [chemical binding]; other site 693444009252 NADPH bind site [chemical binding]; other site 693444009253 Protein of unknown function (DUF1418); Region: DUF1418; pfam07214 693444009254 Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066 693444009255 GSH binding site [chemical binding]; other site 693444009256 catalytic residues [active] 693444009257 Putative inner membrane protein of Enterobacteriaceae; Region: YbjM; pfam11045 693444009258 putative transporter; Provisional; Region: PRK04972 693444009259 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 693444009260 TrkA-C domain; Region: TrkA_C; pfam02080 693444009261 TrkA-C domain; Region: TrkA_C; pfam02080 693444009262 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 693444009263 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 693444009264 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 693444009265 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 693444009266 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693444009267 putative substrate translocation pore; other site 693444009268 Major Facilitator Superfamily; Region: MFS_1; pfam07690 693444009269 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 693444009270 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 693444009271 active site 693444009272 motif I; other site 693444009273 motif II; other site 693444009274 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 693444009275 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 693444009276 multidrug efflux system translocase MdfA; Provisional; Region: PRK15402 693444009277 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693444009278 putative substrate translocation pore; other site 693444009279 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 693444009280 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 693444009281 active site 693444009282 DNA-binding transcriptional repressor DeoR; Provisional; Region: PRK10681 693444009283 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 693444009284 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 693444009285 D-alanyl-D-alanine carboxypeptidase fraction C; Provisional; Region: PRK10001 693444009286 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 693444009287 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 693444009288 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 693444009289 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 693444009290 putative C-terminal domain interface [polypeptide binding]; other site 693444009291 putative GSH binding site (G-site) [chemical binding]; other site 693444009292 putative dimer interface [polypeptide binding]; other site 693444009293 C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180 693444009294 putative N-terminal domain interface [polypeptide binding]; other site 693444009295 putative dimer interface [polypeptide binding]; other site 693444009296 putative substrate binding pocket (H-site) [chemical binding]; other site 693444009297 Transcriptional regulators [Transcription]; Region: PurR; COG1609 693444009298 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 693444009299 DNA binding site [nucleotide binding] 693444009300 domain linker motif; other site 693444009301 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 693444009302 Sugar-binding cellulase-like; Region: Cellulase-like; pfam12876 693444009303 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 693444009304 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 693444009305 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 693444009306 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 693444009307 Biofilm formation protein (YliH/bssR); Region: YliH; cl08211 693444009308 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 693444009309 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 693444009310 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 693444009311 FeS/SAM binding site; other site 693444009312 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 693444009313 DNA-binding site [nucleotide binding]; DNA binding site 693444009314 RNA-binding motif; other site 693444009315 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3122 693444009316 glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082 693444009317 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693444009318 dimer interface [polypeptide binding]; other site 693444009319 conserved gate region; other site 693444009320 putative PBP binding loops; other site 693444009321 ABC-ATPase subunit interface; other site 693444009322 glutathione ABC transporter permease GsiC; Provisional; Region: PRK15081 693444009323 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693444009324 dimer interface [polypeptide binding]; other site 693444009325 conserved gate region; other site 693444009326 putative PBP binding loops; other site 693444009327 ABC-ATPase subunit interface; other site 693444009328 glutathione ABC transporter substrate-binding protein GsiB; Provisional; Region: PRK15413 693444009329 The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499 693444009330 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 693444009331 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 693444009332 Walker A/P-loop; other site 693444009333 ATP binding site [chemical binding]; other site 693444009334 Q-loop/lid; other site 693444009335 ABC transporter signature motif; other site 693444009336 Walker B; other site 693444009337 D-loop; other site 693444009338 H-loop/switch region; other site 693444009339 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 693444009340 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 693444009341 Walker A/P-loop; other site 693444009342 ATP binding site [chemical binding]; other site 693444009343 Q-loop/lid; other site 693444009344 ABC transporter signature motif; other site 693444009345 Walker B; other site 693444009346 D-loop; other site 693444009347 H-loop/switch region; other site 693444009348 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 693444009349 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 693444009350 catalytic nucleophile [active] 693444009351 molybdopterin biosynthesis protein MoeA; Provisional; Region: PRK10680 693444009352 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 693444009353 dimer interface [polypeptide binding]; other site 693444009354 putative functional site; other site 693444009355 putative MPT binding site; other site 693444009356 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 693444009357 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 693444009358 ATP binding site [chemical binding]; other site 693444009359 substrate interface [chemical binding]; other site 693444009360 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 693444009361 active site 693444009362 intersubunit interactions; other site 693444009363 catalytic residue [active] 693444009364 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 693444009365 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 693444009366 FeS/SAM binding site; other site 693444009367 glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774 693444009368 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 693444009369 dimer interface [polypeptide binding]; other site 693444009370 active site 693444009371 glycine loop; other site 693444009372 hypothetical protein; Provisional; Region: PRK09956 693444009373 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 693444009374 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 693444009375 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 693444009376 active site 693444009377 motif I; other site 693444009378 motif II; other site 693444009379 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 693444009380 Protein of unknown function (DUF1479); Region: DUF1479; pfam07350 693444009381 Transcriptional regulators [Transcription]; Region: PurR; COG1609 693444009382 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 693444009383 DNA binding site [nucleotide binding] 693444009384 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 693444009385 ligand binding site [chemical binding]; other site 693444009386 dimerization interface [polypeptide binding]; other site 693444009387 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693444009388 D-galactonate transporter; Region: 2A0114; TIGR00893 693444009389 putative substrate translocation pore; other site 693444009390 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 693444009391 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 693444009392 Glycosyl hydrolase family 31 (GH31) domain of a bacterial protein family represented by Escherichia coli protein Aec37. The gene encoding Aec37 (aec-37) is located within a genomic island (AGI-3) isolated from the extraintestinal avian pathogenic...; Region: GH31_glycosidase_Aec37; cd06599 693444009393 putative active site [active] 693444009394 putative catalytic site [active] 693444009395 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 693444009396 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693444009397 Walker A/P-loop; other site 693444009398 ATP binding site [chemical binding]; other site 693444009399 Q-loop/lid; other site 693444009400 ABC transporter signature motif; other site 693444009401 Walker B; other site 693444009402 D-loop; other site 693444009403 H-loop/switch region; other site 693444009404 ABC transporter; Region: ABC_tran_2; pfam12848 693444009405 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 693444009406 L,D-transpeptidase; Provisional; Region: PRK10260 693444009407 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 693444009408 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 693444009409 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 693444009410 DNA-binding site [nucleotide binding]; DNA binding site 693444009411 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 693444009412 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 693444009413 beta-galactosidase; Region: BGL; TIGR03356 693444009414 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 693444009415 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117 693444009416 transmembrane helices; other site 693444009417 manganese transport regulator MntR; Provisional; Region: PRK11050 693444009418 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 693444009419 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 693444009420 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 693444009421 Sulfatase; Region: Sulfatase; pfam00884 693444009422 outer membrane protein X; Provisional; Region: ompX; PRK09408 693444009423 threonine and homoserine efflux system; Provisional; Region: PRK10532 693444009424 EamA-like transporter family; Region: EamA; cl17759 693444009425 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 693444009426 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 693444009427 dimerization interface [polypeptide binding]; other site 693444009428 DPS ferroxidase diiron center [ion binding]; other site 693444009429 ion pore; other site 693444009430 glutamine ABC transporter periplasmic protein; Reviewed; Region: glnH; PRK09495 693444009431 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 693444009432 substrate binding pocket [chemical binding]; other site 693444009433 membrane-bound complex binding site; other site 693444009434 hinge residues; other site 693444009435 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 693444009436 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693444009437 dimer interface [polypeptide binding]; other site 693444009438 conserved gate region; other site 693444009439 putative PBP binding loops; other site 693444009440 ABC-ATPase subunit interface; other site 693444009441 glutamine ABC transporter ATP-binding protein; Reviewed; Region: glnQ; PRK09493 693444009442 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 693444009443 Walker A/P-loop; other site 693444009444 ATP binding site [chemical binding]; other site 693444009445 Q-loop/lid; other site 693444009446 ABC transporter signature motif; other site 693444009447 Walker B; other site 693444009448 D-loop; other site 693444009449 H-loop/switch region; other site 693444009450 putative mechanosensitive channel protein; Provisional; Region: PRK11465 693444009451 Mechanosensitive ion channel; Region: MS_channel; pfam00924 693444009452 23S rRNA mA1618 methyltransferase; Provisional; Region: PRK11727 693444009453 Protein of unknown function (DUF890); Region: Methyltransf_10; pfam05971 693444009454 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 693444009455 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 693444009456 Protein of unknown function (DUF1090); Region: DUF1090; pfam06476 693444009457 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 693444009458 beta-galactosidase; Region: BGL; TIGR03356 693444009459 PTS system beta-glucoside-specific transporter subunits IIABC; Provisional; Region: PRK09824 693444009460 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 693444009461 active site turn [active] 693444009462 phosphorylation site [posttranslational modification] 693444009463 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 693444009464 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 693444009465 HPr interaction site; other site 693444009466 glycerol kinase (GK) interaction site [polypeptide binding]; other site 693444009467 active site 693444009468 phosphorylation site [posttranslational modification] 693444009469 Survival protein SurE; Region: SurE; pfam01975 693444009470 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 693444009471 catalytic core [active] 693444009472 outer membrane porin, OprD family; Region: OprD; pfam03573 693444009473 transcriptional antiterminator BglG; Provisional; Region: PRK09772 693444009474 CAT RNA binding domain; Region: CAT_RBD; smart01061 693444009475 PRD domain; Region: PRD; pfam00874 693444009476 PRD domain; Region: PRD; pfam00874 693444009477 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 693444009478 Fimbrial protein; Region: Fimbrial; cl01416 693444009479 fimbrial assembly chaperone SthB; Provisional; Region: PRK15295 693444009480 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 693444009481 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 693444009482 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 693444009483 PapC N-terminal domain; Region: PapC_N; pfam13954 693444009484 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 693444009485 PapC C-terminal domain; Region: PapC_C; pfam13953 693444009486 Fimbrial protein; Region: Fimbrial; cl01416 693444009487 catecholate siderophore receptor Fiu; Provisional; Region: PRK09840 693444009488 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 693444009489 N-terminal plug; other site 693444009490 ligand-binding site [chemical binding]; other site 693444009491 Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467 693444009492 hypothetical protein; Provisional; Region: PRK11019 693444009493 Protein of unknown function (DUF1471); Region: DUF1471; cl11507 693444009494 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 693444009495 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 693444009496 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 693444009497 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733 693444009498 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 693444009499 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 693444009500 Protein of unknown function (DUF3828); Region: DUF3828; pfam12883 693444009501 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 693444009502 catalytic residue [active] 693444009503 glycosyl transferase family protein; Provisional; Region: PRK08136 693444009504 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 693444009505 ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747 693444009506 DEAD_2; Region: DEAD_2; pfam06733 693444009507 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 693444009508 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 693444009509 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 693444009510 ATP binding site [chemical binding]; other site 693444009511 Mg++ binding site [ion binding]; other site 693444009512 motif III; other site 693444009513 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 693444009514 nucleotide binding region [chemical binding]; other site 693444009515 ATP-binding site [chemical binding]; other site 693444009516 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11552 693444009517 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 693444009518 Domain of unknown function (DUF1956); Region: DUF1956; pfam09209 693444009519 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 693444009520 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 693444009521 HlyD family secretion protein; Region: HlyD_3; pfam13437 693444009522 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 693444009523 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 693444009524 Walker A/P-loop; other site 693444009525 ATP binding site [chemical binding]; other site 693444009526 Q-loop/lid; other site 693444009527 ABC transporter signature motif; other site 693444009528 Walker B; other site 693444009529 D-loop; other site 693444009530 H-loop/switch region; other site 693444009531 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 693444009532 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 693444009533 Walker A/P-loop; other site 693444009534 ATP binding site [chemical binding]; other site 693444009535 Q-loop/lid; other site 693444009536 ABC transporter signature motif; other site 693444009537 Walker B; other site 693444009538 D-loop; other site 693444009539 H-loop/switch region; other site 693444009540 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 693444009541 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 693444009542 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 693444009543 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 693444009544 Putative inner membrane protein YbhQ; Region: YbhQ; pfam11076 693444009545 Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568 693444009546 putative catalytic site [active] 693444009547 putative metal binding site [ion binding]; other site 693444009548 putative phosphate binding site [ion binding]; other site 693444009549 cardiolipin synthase 2; Provisional; Region: PRK11263 693444009550 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 693444009551 putative active site [active] 693444009552 catalytic site [active] 693444009553 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 693444009554 putative active site [active] 693444009555 catalytic site [active] 693444009556 Predicted integral membrane protein [Function unknown]; Region: COG0392 693444009557 BAX inhibitor (BI)-1/YccA-like protein family; Region: BI-1-like; cl00473 693444009558 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 693444009559 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 693444009560 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 693444009561 MoaE homodimer interface [polypeptide binding]; other site 693444009562 MoaD interaction [polypeptide binding]; other site 693444009563 active site residues [active] 693444009564 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 693444009565 MoaE interaction surface [polypeptide binding]; other site 693444009566 MoeB interaction surface [polypeptide binding]; other site 693444009567 thiocarboxylated glycine; other site 693444009568 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 693444009569 trimer interface [polypeptide binding]; other site 693444009570 dimer interface [polypeptide binding]; other site 693444009571 putative active site [active] 693444009572 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 693444009573 MPT binding site; other site 693444009574 trimer interface [polypeptide binding]; other site 693444009575 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 693444009576 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 693444009577 FeS/SAM binding site; other site 693444009578 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 693444009579 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 693444009580 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 693444009581 phosphate binding site [ion binding]; other site 693444009582 putative substrate binding pocket [chemical binding]; other site 693444009583 dimer interface [polypeptide binding]; other site 693444009584 putative metal dependent hydrolase; Provisional; Region: PRK11598 693444009585 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 693444009586 Sulfatase; Region: Sulfatase; pfam00884 693444009587 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 693444009588 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693444009589 active site 693444009590 phosphorylation site [posttranslational modification] 693444009591 intermolecular recognition site; other site 693444009592 dimerization interface [polypeptide binding]; other site 693444009593 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 693444009594 DNA binding site [nucleotide binding] 693444009595 sensor protein BasS/PmrB; Provisional; Region: PRK10755 693444009596 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 693444009597 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 693444009598 dimer interface [polypeptide binding]; other site 693444009599 phosphorylation site [posttranslational modification] 693444009600 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693444009601 ATP binding site [chemical binding]; other site 693444009602 Mg2+ binding site [ion binding]; other site 693444009603 G-X-G motif; other site 693444009604 excinuclease ABC subunit B; Provisional; Region: PRK05298 693444009605 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 693444009606 ATP binding site [chemical binding]; other site 693444009607 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 693444009608 nucleotide binding region [chemical binding]; other site 693444009609 ATP-binding site [chemical binding]; other site 693444009610 Ultra-violet resistance protein B; Region: UvrB; pfam12344 693444009611 UvrB/uvrC motif; Region: UVR; pfam02151 693444009612 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 693444009613 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693444009614 Walker A/P-loop; other site 693444009615 ATP binding site [chemical binding]; other site 693444009616 Q-loop/lid; other site 693444009617 ABC transporter signature motif; other site 693444009618 Walker B; other site 693444009619 D-loop; other site 693444009620 H-loop/switch region; other site 693444009621 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 693444009622 AAA domain; Region: AAA_26; pfam13500 693444009623 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 693444009624 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693444009625 S-adenosylmethionine binding site [chemical binding]; other site 693444009626 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 693444009627 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 693444009628 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 693444009629 catalytic residue [active] 693444009630 biotin synthase; Provisional; Region: PRK15108 693444009631 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 693444009632 FeS/SAM binding site; other site 693444009633 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 693444009634 adenosylmethionine--8-amino-7-oxononanoate transaminase; Validated; Region: PRK07986 693444009635 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 693444009636 inhibitor-cofactor binding pocket; inhibition site 693444009637 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693444009638 catalytic residue [active] 693444009639 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 693444009640 substrate binding site [chemical binding]; other site 693444009641 acyl-CoA thioesterase; Provisional; Region: PRK10531 693444009642 putative pectinesterase; Region: PLN02432; cl01911 693444009643 6-phosphogluconolactonase; Provisional; Region: PRK11028 693444009644 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693444009645 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 693444009646 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 693444009647 dimerization interface [polypeptide binding]; other site 693444009648 substrate binding pocket [chemical binding]; other site 693444009649 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; pfam01977 693444009650 pyridoxal phosphate (PLP) phosphatase; Provisional; Region: PRK10530 693444009651 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 693444009652 motif II; other site 693444009653 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 693444009654 molybdate transporter ATP-binding protein; Provisional; Region: modC; PRK11144 693444009655 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693444009656 Walker A/P-loop; other site 693444009657 ATP binding site [chemical binding]; other site 693444009658 Q-loop/lid; other site 693444009659 ABC transporter signature motif; other site 693444009660 Walker B; other site 693444009661 D-loop; other site 693444009662 H-loop/switch region; other site 693444009663 molybdenum-pterin binding domain; Region: Mop; TIGR00638 693444009664 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 693444009665 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693444009666 dimer interface [polypeptide binding]; other site 693444009667 conserved gate region; other site 693444009668 putative PBP binding loops; other site 693444009669 ABC-ATPase subunit interface; other site 693444009670 molybdate transporter periplasmic protein; Provisional; Region: modA; PRK10677 693444009671 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 693444009672 substrate binding pocket [chemical binding]; other site 693444009673 membrane-bound complex binding site; other site 693444009674 hinge residues; other site 693444009675 Protein of unknown function (DUF2592); Region: DUF2592; pfam10766 693444009676 DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676 693444009677 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 693444009678 molybdenum-pterin binding domain; Region: Mop; TIGR00638 693444009679 TOBE domain; Region: TOBE; pfam03459 693444009680 putative molybdenum transport ATP-binding protein ModF; Provisional; Region: PRK10938 693444009681 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693444009682 Walker A/P-loop; other site 693444009683 ATP binding site [chemical binding]; other site 693444009684 Q-loop/lid; other site 693444009685 ABC transporter signature motif; other site 693444009686 Walker B; other site 693444009687 D-loop; other site 693444009688 H-loop/switch region; other site 693444009689 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693444009690 Walker A/P-loop; other site 693444009691 ATP binding site [chemical binding]; other site 693444009692 Q-loop/lid; other site 693444009693 ABC transporter signature motif; other site 693444009694 Walker B; other site 693444009695 D-loop; other site 693444009696 H-loop/switch region; other site 693444009697 Protein of unknown function (DUF2167); Region: DUF2167; cl01938 693444009698 UDP-galactose-4-epimerase; Provisional; Region: PRK10675 693444009699 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 693444009700 NAD binding site [chemical binding]; other site 693444009701 homodimer interface [polypeptide binding]; other site 693444009702 active site 693444009703 substrate binding site [chemical binding]; other site 693444009704 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720 693444009705 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 693444009706 dimer interface [polypeptide binding]; other site 693444009707 active site 693444009708 galactokinase; Provisional; Region: PRK05101 693444009709 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 693444009710 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 693444009711 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 693444009712 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 693444009713 active site 693444009714 catalytic residues [active] 693444009715 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 693444009716 catalytic core [active] 693444009717 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 693444009718 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 693444009719 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 693444009720 Walker A/P-loop; other site 693444009721 ATP binding site [chemical binding]; other site 693444009722 Q-loop/lid; other site 693444009723 ABC transporter signature motif; other site 693444009724 Walker B; other site 693444009725 D-loop; other site 693444009726 H-loop/switch region; other site 693444009727 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 693444009728 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 693444009729 ABC-ATPase subunit interface; other site 693444009730 dimer interface [polypeptide binding]; other site 693444009731 putative PBP binding regions; other site 693444009732 Periplasmic binding protein TroA_e. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_e; cd01142 693444009733 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 693444009734 putative ligand binding residues [chemical binding]; other site 693444009735 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 693444009736 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 693444009737 N-terminal plug; other site 693444009738 ligand-binding site [chemical binding]; other site 693444009739 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 693444009740 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 693444009741 YbgS-like protein; Region: YbgS; pfam13985 693444009742 zinc transporter ZitB; Provisional; Region: PRK03557 693444009743 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 693444009744 nicotinamide riboside transporter PnuC; Provisional; Region: PRK15397 693444009745 quinolinate synthetase; Provisional; Region: PRK09375 693444009746 tol-pal system protein YbgF; Provisional; Region: PRK10803 693444009747 Tetratricopeptide repeat; Region: TPR_6; pfam13174 693444009748 peptidoglycan-associated outer membrane lipoprotein; Provisional; Region: PRK10802 693444009749 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 693444009750 ligand binding site [chemical binding]; other site 693444009751 translocation protein TolB; Provisional; Region: tolB; PRK03629 693444009752 TolB amino-terminal domain; Region: TolB_N; pfam04052 693444009753 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 693444009754 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 693444009755 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 693444009756 cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510 693444009757 TolA C-terminal; Region: TolA; pfam06519 693444009758 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 693444009759 colicin uptake protein TolR; Provisional; Region: PRK11024 693444009760 colicin uptake protein TolQ; Provisional; Region: PRK10801 693444009761 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 693444009762 active site 693444009763 hypothetical protein; Provisional; Region: PRK10588 693444009764 Membrane bound YbgT-like protein; Region: YbgT_YccB; cl02039 693444009765 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003 693444009766 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 693444009767 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 693444009768 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 693444009769 alpha-mannosidase; Provisional; Region: PRK09819 693444009770 N-terminal catalytic domain of Escherichia coli alpha-mannosidase MngB and its bacterial homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_EcMngB_like; cd10815 693444009771 active site 693444009772 metal binding site [ion binding]; metal-binding site 693444009773 catalytic site [active] 693444009774 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 693444009775 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 693444009776 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 693444009777 active site 693444009778 phosphorylation site [posttranslational modification] 693444009779 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 693444009780 active site 693444009781 P-loop; other site 693444009782 phosphorylation site [posttranslational modification] 693444009783 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 693444009784 DNA-binding transcriptional repressor MngR; Provisional; Region: PRK09764 693444009785 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 693444009786 DNA-binding site [nucleotide binding]; DNA binding site 693444009787 UTRA domain; Region: UTRA; pfam07702 693444009788 TPR repeat; Region: TPR_11; pfam13414 693444009789 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 693444009790 binding surface 693444009791 TPR motif; other site 693444009792 Tetratricopeptide repeat; Region: TPR_12; pfam13424 693444009793 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 693444009794 CoA binding domain; Region: CoA_binding; smart00881 693444009795 CoA-ligase; Region: Ligase_CoA; pfam00549 693444009796 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 693444009797 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 693444009798 CoA-ligase; Region: Ligase_CoA; pfam00549 693444009799 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 693444009800 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 693444009801 E3 interaction surface; other site 693444009802 lipoyl attachment site [posttranslational modification]; other site 693444009803 e3 binding domain; Region: E3_binding; pfam02817 693444009804 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 693444009805 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 693444009806 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 693444009807 TPP-binding site [chemical binding]; other site 693444009808 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 693444009809 dimer interface [polypeptide binding]; other site 693444009810 PYR/PP interface [polypeptide binding]; other site 693444009811 TPP binding site [chemical binding]; other site 693444009812 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 693444009813 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 693444009814 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08958 693444009815 L-aspartate oxidase; Provisional; Region: PRK06175 693444009816 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 693444009817 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 693444009818 SdhC subunit interface [polypeptide binding]; other site 693444009819 proximal heme binding site [chemical binding]; other site 693444009820 cardiolipin binding site; other site 693444009821 Iron-sulfur protein interface; other site 693444009822 proximal quinone binding site [chemical binding]; other site 693444009823 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 693444009824 Iron-sulfur protein interface; other site 693444009825 proximal quinone binding site [chemical binding]; other site 693444009826 SdhD (CybS) interface [polypeptide binding]; other site 693444009827 proximal heme binding site [chemical binding]; other site 693444009828 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 693444009829 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 693444009830 dimer interface [polypeptide binding]; other site 693444009831 active site 693444009832 citrylCoA binding site [chemical binding]; other site 693444009833 NADH binding [chemical binding]; other site 693444009834 cationic pore residues; other site 693444009835 oxalacetate/citrate binding site [chemical binding]; other site 693444009836 coenzyme A binding site [chemical binding]; other site 693444009837 catalytic triad [active] 693444009838 Protein of unknown function (DUF796); Region: DUF796; cl01226 693444009839 S-type Pyocin; Region: Pyocin_S; pfam06958 693444009840 DNase/tRNase domain of colicin-like bacteriocin; Region: Colicin-DNase; pfam12639 693444009841 Colicin immunity protein / pyocin immunity protein; Region: Colicin_Pyocin; pfam01320 693444009842 endonuclease VIII; Provisional; Region: PRK10445 693444009843 N-terminal domain of Escherichia coli Nei/endonuclease VIII and related DNA glycosylases; Region: EcNei-like_N; cd08965 693444009844 DNA binding site [nucleotide binding] 693444009845 catalytic residue [active] 693444009846 putative catalytic residues [active] 693444009847 H2TH interface [polypeptide binding]; other site 693444009848 intercalation triad [nucleotide binding]; other site 693444009849 substrate specificity determining residue; other site 693444009850 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 693444009851 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 693444009852 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 693444009853 putative substrate binding pocket [chemical binding]; other site 693444009854 AC domain interface; other site 693444009855 catalytic triad [active] 693444009856 AB domain interface; other site 693444009857 interchain disulfide; other site 693444009858 Predicted membrane protein [Function unknown]; Region: COG3817 693444009859 Protein of unknown function (DUF979); Region: DUF979; pfam06166 693444009860 Protein of unknown function (DUF969); Region: DUF969; pfam06149 693444009861 Escherichia coli putative lactam utilization protein YbgL and similar proteins; Region: LamB_YcsF_YbgL_like; cd10800 693444009862 putative active site [active] 693444009863 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 693444009864 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 693444009865 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 693444009866 Uncharacterized conserved protein [Function unknown]; Region: COG0327 693444009867 metal-binding protein; Provisional; Region: PRK10799 693444009868 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 693444009869 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693444009870 POT family; Region: PTR2; pfam00854 693444009871 deoxyribodipyrimidine photolyase; Provisional; Region: PRK10674 693444009872 DNA photolyase; Region: DNA_photolyase; pfam00875 693444009873 Protein of unknown function (DUF523); Region: DUF523; pfam04463 693444009874 Uncharacterized conserved protein [Function unknown]; Region: COG3272 693444009875 Protein of unknown function (DUF1722); Region: DUF1722; cl01284 693444009876 Protein of unknown function (DUF2517); Region: DUF2517; pfam10725 693444009877 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 693444009878 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 693444009879 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 693444009880 potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315 693444009881 sensor protein KdpD; Provisional; Region: PRK10490 693444009882 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 693444009883 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 693444009884 Ligand Binding Site [chemical binding]; other site 693444009885 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 693444009886 GAF domain; Region: GAF_3; pfam13492 693444009887 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 693444009888 dimer interface [polypeptide binding]; other site 693444009889 phosphorylation site [posttranslational modification] 693444009890 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693444009891 ATP binding site [chemical binding]; other site 693444009892 Mg2+ binding site [ion binding]; other site 693444009893 G-X-G motif; other site 693444009894 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 693444009895 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693444009896 active site 693444009897 phosphorylation site [posttranslational modification] 693444009898 intermolecular recognition site; other site 693444009899 dimerization interface [polypeptide binding]; other site 693444009900 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 693444009901 DNA binding site [nucleotide binding] 693444009902 ornithine decarboxylase; Provisional; Region: PRK13578 693444009903 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 693444009904 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 693444009905 homodimer interface [polypeptide binding]; other site 693444009906 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693444009907 catalytic residue [active] 693444009908 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 693444009909 phosphoglucomutase, alpha-D-glucose phosphate-specific; Region: pgm; TIGR01132 693444009910 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 693444009911 active site 693444009912 substrate binding site [chemical binding]; other site 693444009913 metal binding site [ion binding]; metal-binding site 693444009914 replication initiation regulator SeqA; Provisional; Region: PRK11187 693444009915 acyl-CoA esterase; Provisional; Region: PRK10673 693444009916 PGAP1-like protein; Region: PGAP1; pfam07819 693444009917 LexA regulated protein; Provisional; Region: PRK11675 693444009918 flavodoxin FldA; Validated; Region: PRK09267 693444009919 ferric uptake regulator; Provisional; Region: fur; PRK09462 693444009920 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 693444009921 metal binding site 2 [ion binding]; metal-binding site 693444009922 putative DNA binding helix; other site 693444009923 metal binding site 1 [ion binding]; metal-binding site 693444009924 dimer interface [polypeptide binding]; other site 693444009925 structural Zn2+ binding site [ion binding]; other site 693444009926 nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233 693444009927 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693444009928 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 693444009929 putative dimerization interface [polypeptide binding]; other site 693444009930 tricarballylate dehydrogenase; Validated; Region: PRK08274 693444009931 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 693444009932 tricarballylate utilization protein B; Provisional; Region: PRK15033 693444009933 citrate-proton symporter; Provisional; Region: PRK15075 693444009934 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693444009935 putative substrate translocation pore; other site 693444009936 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 693444009937 YbfN-like lipoprotein; Region: YbfN; pfam13982 693444009938 outer membrane porin, OprD family; Region: OprD; pfam03573 693444009939 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 693444009940 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 693444009941 active site 693444009942 HIGH motif; other site 693444009943 nucleotide binding site [chemical binding]; other site 693444009944 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 693444009945 KMSKS motif; other site 693444009946 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 693444009947 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 693444009948 PTS system N-acetyl glucosamine specific transporter subunits IIABC; Provisional; Region: PRK10255 693444009949 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 693444009950 active site turn [active] 693444009951 phosphorylation site [posttranslational modification] 693444009952 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 693444009953 HPr interaction site; other site 693444009954 glycerol kinase (GK) interaction site [polypeptide binding]; other site 693444009955 active site 693444009956 phosphorylation site [posttranslational modification] 693444009957 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 693444009958 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 693444009959 active site 693444009960 trimer interface [polypeptide binding]; other site 693444009961 allosteric site; other site 693444009962 active site lid [active] 693444009963 hexamer (dimer of trimers) interface [polypeptide binding]; other site 693444009964 N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221 693444009965 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 693444009966 active site 693444009967 dimer interface [polypeptide binding]; other site 693444009968 MarR family; Region: MarR; pfam01047 693444009969 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 693444009970 ROK family; Region: ROK; pfam00480 693444009971 UMP phosphatase; Provisional; Region: PRK10444 693444009972 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 693444009973 active site 693444009974 motif I; other site 693444009975 motif II; other site 693444009976 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 693444009977 asparagine synthetase B; Provisional; Region: asnB; PRK09431 693444009978 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 693444009979 active site 693444009980 dimer interface [polypeptide binding]; other site 693444009981 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 693444009982 Ligand Binding Site [chemical binding]; other site 693444009983 Molecular Tunnel; other site 693444009984 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Reviewed; Region: ubiF; PRK08020 693444009985 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 693444009986 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 693444009987 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 693444009988 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 693444009989 FeS/SAM binding site; other site 693444009990 TRAM domain; Region: TRAM; pfam01938 693444009991 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 693444009992 PhoH-like protein; Region: PhoH; pfam02562 693444009993 metal-binding heat shock protein; Provisional; Region: PRK00016 693444009994 magnesium/cobalt efflux protein CorC; Provisional; Region: PRK15094 693444009995 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 693444009996 Transporter associated domain; Region: CorC_HlyC; smart01091 693444009997 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 693444009998 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 693444009999 putative active site [active] 693444010000 catalytic triad [active] 693444010001 putative dimer interface [polypeptide binding]; other site 693444010002 glutamate and aspartate transporter subunit; Provisional; Region: PRK10797 693444010003 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 693444010004 substrate binding pocket [chemical binding]; other site 693444010005 membrane-bound complex binding site; other site 693444010006 hinge residues; other site 693444010007 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 693444010008 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693444010009 dimer interface [polypeptide binding]; other site 693444010010 conserved gate region; other site 693444010011 putative PBP binding loops; other site 693444010012 ABC-ATPase subunit interface; other site 693444010013 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 693444010014 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693444010015 dimer interface [polypeptide binding]; other site 693444010016 conserved gate region; other site 693444010017 putative PBP binding loops; other site 693444010018 ABC-ATPase subunit interface; other site 693444010019 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 693444010020 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 693444010021 Walker A/P-loop; other site 693444010022 ATP binding site [chemical binding]; other site 693444010023 Q-loop/lid; other site 693444010024 ABC transporter signature motif; other site 693444010025 Walker B; other site 693444010026 D-loop; other site 693444010027 H-loop/switch region; other site 693444010028 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 693444010029 active site 693444010030 tetramer interface [polypeptide binding]; other site 693444010031 hypothetical protein; Provisional; Region: PRK11032 693444010032 SPX domain; Region: SPX; pfam03105 693444010033 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 693444010034 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 693444010035 HIGH motif; other site 693444010036 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 693444010037 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 693444010038 active site 693444010039 KMSKS motif; other site 693444010040 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 693444010041 tRNA binding surface [nucleotide binding]; other site 693444010042 LPS-assembly lipoprotein RlpB; Provisional; Region: PRK10796 693444010043 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 693444010044 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 693444010045 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 693444010046 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 693444010047 active site 693444010048 (T/H)XGH motif; other site 693444010049 threonine-phosphate decarboxylase; Provisional; Region: PRK08056 693444010050 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 693444010051 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693444010052 homodimer interface [polypeptide binding]; other site 693444010053 catalytic residue [active] 693444010054 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 693444010055 catalytic core [active] 693444010056 ribosome-associated protein; Provisional; Region: PRK11538 693444010057 rRNA large subunit m3Psi methyltransferase RlmH; Region: tRNA_RlmH_YbeA; TIGR00246 693444010058 penicillin-binding protein 2; Provisional; Region: PRK10795 693444010059 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 693444010060 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 693444010061 cell wall shape-determining protein; Provisional; Region: PRK10794 693444010062 rare lipoprotein A; Provisional; Region: PRK10672 693444010063 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 693444010064 Sporulation related domain; Region: SPOR; pfam05036 693444010065 D-alanyl-D-alanine carboxypeptidase fraction A; Provisional; Region: PRK10793 693444010066 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 693444010067 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 693444010068 hypothetical protein; Provisional; Region: PRK04998 693444010069 lipoate-protein ligase B; Provisional; Region: PRK14342 693444010070 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11482 693444010071 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693444010072 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 693444010073 substrate binding pocket [chemical binding]; other site 693444010074 dimerization interface [polypeptide binding]; other site 693444010075 lipoyl synthase; Provisional; Region: PRK05481 693444010076 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 693444010077 FeS/SAM binding site; other site 693444010078 twin arginine translocase protein E; Validated; Region: tatE; PRK03625 693444010079 Predicted amidohydrolase [General function prediction only]; Region: COG0388 693444010080 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 693444010081 putative active site [active] 693444010082 catalytic triad [active] 693444010083 putative dimer interface [polypeptide binding]; other site 693444010084 chromosome condensation membrane protein; Provisional; Region: PRK14196 693444010085 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 693444010086 DNA-binding site [nucleotide binding]; DNA binding site 693444010087 RNA-binding motif; other site 693444010088 phospholipid:lipid A palmitoyltransferase; Provisional; Region: pagP; PRK11045 693444010089 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 693444010090 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 693444010091 HlyD family secretion protein; Region: HlyD_3; pfam13437 693444010092 Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604 693444010093 Outer membrane efflux protein; Region: OEP; pfam02321 693444010094 Outer membrane efflux protein; Region: OEP; pfam02321 693444010095 Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604 693444010096 C4-dicarboxylate transporter DcuC; Provisional; Region: dcuC; PRK10654 693444010097 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 693444010098 Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062 693444010099 B1 nucleotide binding pocket [chemical binding]; other site 693444010100 B2 nucleotide binding pocket [chemical binding]; other site 693444010101 CAS motifs; other site 693444010102 active site 693444010103 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 693444010104 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 693444010105 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 693444010106 Ligand Binding Site [chemical binding]; other site 693444010107 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 693444010108 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 693444010109 catalytic residue [active] 693444010110 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 693444010111 catalytic residues [active] 693444010112 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 693444010113 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 693444010114 alkyl hydroperoxide reductase subunit C; Provisional; Region: PRK10382 693444010115 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 693444010116 dimer interface [polypeptide binding]; other site 693444010117 decamer (pentamer of dimers) interface [polypeptide binding]; other site 693444010118 catalytic triad [active] 693444010119 peroxidatic and resolving cysteines [active] 693444010120 disulfide isomerase/thiol-disulfide oxidase; Provisional; Region: dsbG; PRK11657 693444010121 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 693444010122 dimerization domain [polypeptide binding]; other site 693444010123 dimer interface [polypeptide binding]; other site 693444010124 catalytic residues [active] 693444010125 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693444010126 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693444010127 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 693444010128 Predicted phosphoadenosine phosphosulfate sulfotransferase [General function prediction only]; Region: COG3969 693444010129 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 693444010130 Active Sites [active] 693444010131 Domain of unknown function (DUF3440); Region: DUF3440; pfam11922 693444010132 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 693444010133 ParB-like nuclease domain; Region: ParBc; pfam02195 693444010134 methionine aminotransferase; Validated; Region: PRK09082 693444010135 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 693444010136 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693444010137 homodimer interface [polypeptide binding]; other site 693444010138 catalytic residue [active] 693444010139 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 693444010140 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 693444010141 putative active site [active] 693444010142 metal binding site [ion binding]; metal-binding site 693444010143 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 693444010144 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 693444010145 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 693444010146 salt bridge; other site 693444010147 non-specific DNA binding site [nucleotide binding]; other site 693444010148 sequence-specific DNA binding site [nucleotide binding]; other site 693444010149 Uncharacterized small protein [Function unknown]; Region: COG2879 693444010150 carbon starvation protein A; Provisional; Region: PRK15015 693444010151 Carbon starvation protein CstA; Region: CstA; pfam02554 693444010152 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 693444010153 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 693444010154 CoenzymeA binding site [chemical binding]; other site 693444010155 subunit interaction site [polypeptide binding]; other site 693444010156 PHB binding site; other site 693444010157 2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220 693444010158 2,3 dihydro-2,3 dihydrozybenzoate dehydrogenases, classical (c) SDRs; Region: DH-DHB-DH_SDR_c; cd05331 693444010159 putative NAD(P) binding site [chemical binding]; other site 693444010160 active site 693444010161 Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013 693444010162 hydrophobic substrate binding pocket; other site 693444010163 Isochorismatase family; Region: Isochorismatase; pfam00857 693444010164 active site 693444010165 conserved cis-peptide bond; other site 693444010166 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 693444010167 enterobactin synthase subunit E; Provisional; Region: entE; PRK10946 693444010168 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 693444010169 acyl-activating enzyme (AAE) consensus motif; other site 693444010170 active site 693444010171 AMP binding site [chemical binding]; other site 693444010172 substrate binding site [chemical binding]; other site 693444010173 isochorismate synthase EntC; Provisional; Region: PRK15016 693444010174 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 693444010175 iron-enterobactin transporter periplasmic binding protein; Provisional; Region: PRK10957 693444010176 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 693444010177 siderophore binding site; other site 693444010178 enterobactin exporter EntS; Provisional; Region: PRK10489 693444010179 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693444010180 putative substrate translocation pore; other site 693444010181 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 693444010182 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 693444010183 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 693444010184 ABC-ATPase subunit interface; other site 693444010185 dimer interface [polypeptide binding]; other site 693444010186 putative PBP binding regions; other site 693444010187 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 693444010188 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 693444010189 ABC-ATPase subunit interface; other site 693444010190 dimer interface [polypeptide binding]; other site 693444010191 putative PBP binding regions; other site 693444010192 iron-enterobactin transporter ATP-binding protein; Provisional; Region: PRK10253 693444010193 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 693444010194 Walker A/P-loop; other site 693444010195 ATP binding site [chemical binding]; other site 693444010196 Q-loop/lid; other site 693444010197 ABC transporter signature motif; other site 693444010198 Walker B; other site 693444010199 D-loop; other site 693444010200 H-loop/switch region; other site 693444010201 Chain length determinant protein [Cell envelope biogenesis, outer membrane]; Region: WzzB; COG3765 693444010202 Chain length determinant protein; Region: Wzz; cl15801 693444010203 UDP-D-galactose:(glucosyl)lipopolysaccharide-1, 6-D-galactosyltransferase; Provisional; Region: PRK09922 693444010204 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 693444010205 putative ADP-binding pocket [chemical binding]; other site 693444010206 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 693444010207 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 693444010208 acyl-activating enzyme (AAE) consensus motif; other site 693444010209 AMP binding site [chemical binding]; other site 693444010210 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 693444010211 MbtH-like protein; Region: MbtH; cl01279 693444010212 enterobactin/ferric enterobactin esterase; Provisional; Region: PRK10439 693444010213 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 693444010214 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 693444010215 outer membrane receptor FepA; Provisional; Region: PRK13524 693444010216 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 693444010217 N-terminal plug; other site 693444010218 ligand-binding site [chemical binding]; other site 693444010219 phosphopantetheinyltransferase component of enterobactin synthase multienzyme complex; Provisional; Region: PRK10251 693444010220 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 693444010221 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 693444010222 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 693444010223 active site 693444010224 FMN binding site [chemical binding]; other site 693444010225 substrate binding site [chemical binding]; other site 693444010226 homotetramer interface [polypeptide binding]; other site 693444010227 catalytic residue [active] 693444010228 p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819 693444010229 Putative p-aminobenzoyl-glutamate transporter [Coenzyme metabolism]; Region: AbgT; COG2978 693444010230 gamma-glutamyl:cysteine ligase; Provisional; Region: PRK13516 693444010231 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 693444010232 Predicted periplasmic protein [Function unknown]; Region: COG3698 693444010233 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 693444010234 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 693444010235 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 693444010236 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 693444010237 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 693444010238 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 693444010239 motif II; other site 693444010240 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 693444010241 Protein of unknown function (DUF1158); Region: DUF1158; pfam06643 693444010242 enterobactin/ferric enterobactin esterase; Provisional; Region: PRK10439 693444010243 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 693444010244 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 693444010245 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 693444010246 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 693444010247 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 693444010248 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 693444010249 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 693444010250 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 693444010251 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 693444010252 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 693444010253 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693444010254 homodimer interface [polypeptide binding]; other site 693444010255 catalytic residue [active] 693444010256 Protein of unknown function (DUF419); Region: DUF419; cl15265 693444010257 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 693444010258 dimer interface [polypeptide binding]; other site 693444010259 FMN binding site [chemical binding]; other site 693444010260 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 693444010261 Mechanosensitive ion channel; Region: MS_channel; pfam00924 693444010262 Transcriptional regulators [Transcription]; Region: PurR; COG1609 693444010263 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 693444010264 DNA binding site [nucleotide binding] 693444010265 domain linker motif; other site 693444010266 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 693444010267 dimerization interface [polypeptide binding]; other site 693444010268 ligand binding site [chemical binding]; other site 693444010269 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 693444010270 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 693444010271 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 693444010272 phenylalanine transporter; Provisional; Region: PRK10249 693444010273 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 693444010274 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 693444010275 N-terminal plug; other site 693444010276 ligand-binding site [chemical binding]; other site 693444010277 threonine and homoserine efflux system; Provisional; Region: PRK10532 693444010278 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 693444010279 Zn2+ binding site [ion binding]; other site 693444010280 Mg2+ binding site [ion binding]; other site 693444010281 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 693444010282 Zn2+ binding site [ion binding]; other site 693444010283 Mg2+ binding site [ion binding]; other site 693444010284 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 693444010285 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 693444010286 active site 693444010287 non-prolyl cis peptide bond; other site 693444010288 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 693444010289 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693444010290 dimer interface [polypeptide binding]; other site 693444010291 conserved gate region; other site 693444010292 putative PBP binding loops; other site 693444010293 ABC-ATPase subunit interface; other site 693444010294 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 693444010295 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 693444010296 membrane-bound complex binding site; other site 693444010297 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 693444010298 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 693444010299 Walker A/P-loop; other site 693444010300 ATP binding site [chemical binding]; other site 693444010301 Q-loop/lid; other site 693444010302 ABC transporter signature motif; other site 693444010303 Walker B; other site 693444010304 D-loop; other site 693444010305 H-loop/switch region; other site 693444010306 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 693444010307 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 693444010308 Walker A/P-loop; other site 693444010309 ATP binding site [chemical binding]; other site 693444010310 Q-loop/lid; other site 693444010311 ABC transporter signature motif; other site 693444010312 Walker B; other site 693444010313 D-loop; other site 693444010314 H-loop/switch region; other site 693444010315 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 693444010316 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693444010317 dimer interface [polypeptide binding]; other site 693444010318 conserved gate region; other site 693444010319 putative PBP binding loops; other site 693444010320 ABC-ATPase subunit interface; other site 693444010321 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 693444010322 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 693444010323 substrate binding pocket [chemical binding]; other site 693444010324 membrane-bound complex binding site; other site 693444010325 hinge residues; other site 693444010326 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 693444010327 classical (c) SDRs; Region: SDR_c; cd05233 693444010328 NAD(P) binding site [chemical binding]; other site 693444010329 active site 693444010330 4-hydroxyphenylacetate catabolism regulatory protein HpaA; Region: HpaA; TIGR02297 693444010331 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 693444010332 NIPSNAP; Region: NIPSNAP; pfam07978 693444010333 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 693444010334 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 693444010335 active site 693444010336 FMN binding site [chemical binding]; other site 693444010337 substrate binding site [chemical binding]; other site 693444010338 homotetramer interface [polypeptide binding]; other site 693444010339 catalytic residue [active] 693444010340 putative succinate dehydrogenase; Reviewed; Region: PRK12842 693444010341 L-aspartate oxidase; Provisional; Region: PRK06175 693444010342 Predicted oxidoreductase [General function prediction only]; Region: COG3573 693444010343 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 693444010344 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 693444010345 DHHA2 domain; Region: DHHA2; pfam02833 693444010346 transcriptional regulator FimZ; Provisional; Region: PRK09935 693444010347 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693444010348 active site 693444010349 phosphorylation site [posttranslational modification] 693444010350 intermolecular recognition site; other site 693444010351 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 693444010352 DNA binding residues [nucleotide binding] 693444010353 dimerization interface [polypeptide binding]; other site 693444010354 Fimbrial protein; Region: Fimbrial; cl01416 693444010355 Fimbrial protein; Region: Fimbrial; cl01416 693444010356 outer membrane usher protein FimD; Provisional; Region: PRK15198 693444010357 PapC N-terminal domain; Region: PapC_N; pfam13954 693444010358 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 693444010359 PapC C-terminal domain; Region: PapC_C; pfam13953 693444010360 fimbrial chaperone protein FimC; Provisional; Region: PRK15195 693444010361 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 693444010362 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 693444010363 Fimbrial protein; Region: Fimbrial; cl01416 693444010364 Fimbrial protein; Region: Fimbrial; cl01416 693444010365 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792 693444010366 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 693444010367 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 693444010368 homodimer interface [polypeptide binding]; other site 693444010369 NADP binding site [chemical binding]; other site 693444010370 substrate binding site [chemical binding]; other site 693444010371 ribosome-associated protein; Provisional; Region: PRK11507 693444010372 YARHG domain; Region: YARHG; pfam13308 693444010373 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 693444010374 putative lipoprotein/autotransporter domain-containing protein; Provisional; Region: PRK14849 693444010375 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 693444010376 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 693444010377 Autotransporter beta-domain; Region: Autotransporter; pfam03797 693444010378 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 693444010379 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 693444010380 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 693444010381 active site turn [active] 693444010382 phosphorylation site [posttranslational modification] 693444010383 DNA-binding transcriptional repressor MalI; Provisional; Region: PRK10014 693444010384 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 693444010385 DNA binding site [nucleotide binding] 693444010386 domain linker motif; other site 693444010387 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 693444010388 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 693444010389 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 693444010390 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 693444010391 active site 693444010392 HIGH motif; other site 693444010393 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 693444010394 KMSKS motif; other site 693444010395 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 693444010396 tRNA binding surface [nucleotide binding]; other site 693444010397 anticodon binding site; other site 693444010398 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 693444010399 substrate binding site [chemical binding]; other site 693444010400 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 693444010401 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 693444010402 putative active site [active] 693444010403 putative metal binding site [ion binding]; other site 693444010404 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 693444010405 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 693444010406 ATP-grasp domain; Region: ATP-grasp; pfam02222 693444010407 tRNA 2-selenouridine synthase; Provisional; Region: PRK11784 693444010408 Member of the Rhodanese Homology Domain superfamily. This CD includes several putative ATP /GTP binding proteins including E. coli YbbB; Region: RHOD_YbbB; cd01520 693444010409 active site residue [active] 693444010410 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693444010411 dimer interface [polypeptide binding]; other site 693444010412 conserved gate region; other site 693444010413 ABC-ATPase subunit interface; other site 693444010414 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 693444010415 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 693444010416 Walker A/P-loop; other site 693444010417 ATP binding site [chemical binding]; other site 693444010418 Q-loop/lid; other site 693444010419 ABC transporter signature motif; other site 693444010420 Walker B; other site 693444010421 D-loop; other site 693444010422 H-loop/switch region; other site 693444010423 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 693444010424 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 693444010425 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 693444010426 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 693444010427 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 693444010428 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 693444010429 FtsX-like permease family; Region: FtsX; pfam02687 693444010430 putative ABC transporter ATP-binding protein YbbA; Provisional; Region: PRK10584 693444010431 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 693444010432 Walker A/P-loop; other site 693444010433 ATP binding site [chemical binding]; other site 693444010434 Q-loop/lid; other site 693444010435 ABC transporter signature motif; other site 693444010436 Walker B; other site 693444010437 D-loop; other site 693444010438 H-loop/switch region; other site 693444010439 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 693444010440 active site 693444010441 catalytic triad [active] 693444010442 oxyanion hole [active] 693444010443 switch loop; other site 693444010444 oxidoreductase; Provisional; Region: PRK08017 693444010445 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 693444010446 NADP binding site [chemical binding]; other site 693444010447 active site 693444010448 steroid binding site; other site 693444010449 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 693444010450 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 693444010451 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 693444010452 putative ABC transporter ATP-binding protein YbbL; Provisional; Region: PRK10247 693444010453 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693444010454 Walker A/P-loop; other site 693444010455 ATP binding site [chemical binding]; other site 693444010456 Q-loop/lid; other site 693444010457 ABC transporter signature motif; other site 693444010458 Walker B; other site 693444010459 D-loop; other site 693444010460 H-loop/switch region; other site 693444010461 YadA-like C-terminal region; Region: YadA; pfam03895 693444010462 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 693444010463 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 693444010464 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 693444010465 DNA-binding transcriptional regulator CueR; Provisional; Region: PRK10227 693444010466 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 693444010467 DNA binding residues [nucleotide binding] 693444010468 dimer interface [polypeptide binding]; other site 693444010469 copper binding site [ion binding]; other site 693444010470 coproporphyrinogen III oxidase; Provisional; Region: PRK09058 693444010471 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 693444010472 FeS/SAM binding site; other site 693444010473 Putative heme iron utilization protein [Inorganic ion transport and metabolism]; Region: HugX; COG3721 693444010474 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 693444010475 NADH(P)-binding; Region: NAD_binding_10; pfam13460 693444010476 NAD(P) binding site [chemical binding]; other site 693444010477 putative active site [active] 693444010478 copper exporting ATPase; Provisional; Region: copA; PRK10671 693444010479 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 693444010480 metal-binding site [ion binding] 693444010481 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 693444010482 metal-binding site [ion binding] 693444010483 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 693444010484 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 693444010485 motif II; other site 693444010486 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3735 693444010487 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 693444010488 putative deacylase active site [active] 693444010489 bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558 693444010490 Escherichia coli UshA and related proteins, N-terminal metallophosphatase domain; Region: MPP_UshA_N; cd07405 693444010491 active site 693444010492 metal binding site [ion binding]; metal-binding site 693444010493 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 693444010494 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693444010495 Major Facilitator Superfamily; Region: MFS_1; pfam07690 693444010496 putative substrate translocation pore; other site 693444010497 putative cation:proton antiport protein; Provisional; Region: PRK10669 693444010498 Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651 693444010499 TrkA-N domain; Region: TrkA_N; pfam02254 693444010500 inosine/guanosine kinase; Provisional; Region: PRK15074 693444010501 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 693444010502 acetyl esterase; Provisional; Region: PRK10162 693444010503 ferrochelatase; Reviewed; Region: hemH; PRK00035 693444010504 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 693444010505 C-terminal domain interface [polypeptide binding]; other site 693444010506 active site 693444010507 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 693444010508 active site 693444010509 N-terminal domain interface [polypeptide binding]; other site 693444010510 adenylate kinase; Reviewed; Region: adk; PRK00279 693444010511 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 693444010512 AMP-binding site [chemical binding]; other site 693444010513 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 693444010514 heat shock protein 90; Provisional; Region: PRK05218 693444010515 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693444010516 ATP binding site [chemical binding]; other site 693444010517 Mg2+ binding site [ion binding]; other site 693444010518 G-X-G motif; other site 693444010519 Recombinational DNA repair protein (RecF pathway) [DNA replication, recombination, and repair]; Region: RecR; COG0353 693444010520 RecR protein; Region: RecR; pfam02132 693444010521 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 693444010522 putative active site [active] 693444010523 putative metal-binding site [ion binding]; other site 693444010524 tetramer interface [polypeptide binding]; other site 693444010525 hypothetical protein; Validated; Region: PRK00153 693444010526 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994 693444010527 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693444010528 Walker A motif; other site 693444010529 ATP binding site [chemical binding]; other site 693444010530 Walker B motif; other site 693444010531 arginine finger; other site 693444010532 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 693444010533 DNA polymerase III subunits tau domain IV DnaB-binding; Region: DNA_pol3_tau_4; pfam12168 693444010534 DNA polymerase III tau subunit V interacting with alpha; Region: DNA_pol3_tau_5; pfam12170 693444010535 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 693444010536 active site 693444010537 hypothetical protein; Provisional; Region: PRK10527 693444010538 Primosomal replication protein priB and priC; Region: priB_priC; cl11483 693444010539 hypothetical protein; Provisional; Region: PRK11038 693444010540 hypothetical protein; Provisional; Region: PRK11281 693444010541 Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits...; Region: Prefoldin; cl09111 693444010542 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 693444010543 NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; cl00779 693444010544 Mechanosensitive ion channel; Region: MS_channel; pfam00924 693444010545 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 693444010546 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 693444010547 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 693444010548 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 693444010549 HlyD family secretion protein; Region: HlyD_3; pfam13437 693444010550 Animal heme peroxidases and related proteins; Region: An_peroxidase_like; cl14561 693444010551 substrate binding site [chemical binding]; other site 693444010552 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 693444010553 Protein export membrane protein; Region: SecD_SecF; cl14618 693444010554 Protein export membrane protein; Region: SecD_SecF; cl14618 693444010555 Hha toxicity attenuator; Provisional; Region: PRK10667 693444010556 gene expression modulator; Provisional; Region: PRK10945 693444010557 maltose O-acetyltransferase; Provisional; Region: PRK10092 693444010558 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 693444010559 active site 693444010560 substrate binding site [chemical binding]; other site 693444010561 trimer interface [polypeptide binding]; other site 693444010562 CoA binding site [chemical binding]; other site 693444010563 sigma70 family sigma factor YlaC; Region: YlaC; pfam10777 693444010564 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 693444010565 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 693444010566 DNA-binding site [nucleotide binding]; DNA binding site 693444010567 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 693444010568 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693444010569 homodimer interface [polypeptide binding]; other site 693444010570 catalytic residue [active] 693444010571 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 693444010572 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 693444010573 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 693444010574 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 693444010575 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 693444010576 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 693444010577 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 693444010578 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 693444010579 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 693444010580 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 693444010581 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 693444010582 Walker A/P-loop; other site 693444010583 ATP binding site [chemical binding]; other site 693444010584 Q-loop/lid; other site 693444010585 ABC transporter signature motif; other site 693444010586 Walker B; other site 693444010587 D-loop; other site 693444010588 H-loop/switch region; other site 693444010589 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693444010590 dimer interface [polypeptide binding]; other site 693444010591 conserved gate region; other site 693444010592 ABC-ATPase subunit interface; other site 693444010593 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 693444010594 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 693444010595 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 693444010596 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 693444010597 Protein of unknown function (DUF1428); Region: DUF1428; cl02319 693444010598 Predicted membrane protein [Function unknown]; Region: COG2364 693444010599 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 693444010600 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 693444010601 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 693444010602 DNA-binding site [nucleotide binding]; DNA binding site 693444010603 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 693444010604 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693444010605 homodimer interface [polypeptide binding]; other site 693444010606 catalytic residue [active] 693444010607 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 693444010608 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 693444010609 DNA binding site [nucleotide binding] 693444010610 active site 693444010611 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3126 693444010612 acyl-CoA thioesterase II; Provisional; Region: PRK10526 693444010613 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 693444010614 active site 693444010615 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 693444010616 catalytic triad [active] 693444010617 dimer interface [polypeptide binding]; other site 693444010618 ammonium transporter; Provisional; Region: PRK10666 693444010619 nitrogen regulatory protein P-II 2; Provisional; Region: PRK10665 693444010620 Nitrogen regulatory protein P-II; Region: P-II; smart00938 693444010621 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10790 693444010622 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 693444010623 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 693444010624 Walker A/P-loop; other site 693444010625 ATP binding site [chemical binding]; other site 693444010626 Q-loop/lid; other site 693444010627 ABC transporter signature motif; other site 693444010628 Walker B; other site 693444010629 D-loop; other site 693444010630 H-loop/switch region; other site 693444010631 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 693444010632 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 693444010633 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693444010634 Walker A/P-loop; other site 693444010635 ATP binding site [chemical binding]; other site 693444010636 Q-loop/lid; other site 693444010637 ABC transporter signature motif; other site 693444010638 Walker B; other site 693444010639 D-loop; other site 693444010640 H-loop/switch region; other site 693444010641 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 693444010642 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 693444010643 putative DNA binding site [nucleotide binding]; other site 693444010644 putative Zn2+ binding site [ion binding]; other site 693444010645 AsnC family; Region: AsnC_trans_reg; pfam01037 693444010646 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 693444010647 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 693444010648 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 693444010649 catalytic residue [active] 693444010650 thiamin pyrimidine pyrophosphate hydrolase; Provisional; Region: PRK15126 693444010651 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 693444010652 active site 693444010653 motif I; other site 693444010654 motif II; other site 693444010655 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 693444010656 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 693444010657 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 693444010658 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 693444010659 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 693444010660 Ligand Binding Site [chemical binding]; other site 693444010661 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 693444010662 active site 693444010663 competence protein ComEA helix-hairpin-helix repeat region; Region: TIGR00426 693444010664 periplasmic folding chaperone; Provisional; Region: PRK10788 693444010665 SurA N-terminal domain; Region: SurA_N_3; cl07813 693444010666 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 693444010667 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 693444010668 IHF dimer interface [polypeptide binding]; other site 693444010669 IHF - DNA interface [nucleotide binding]; other site 693444010670 DNA-binding ATP-dependent protease La; Provisional; Region: PRK10787 693444010671 Found in ATP-dependent protease La (LON); Region: LON; smart00464 693444010672 Found in ATP-dependent protease La (LON); Region: LON; smart00464 693444010673 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693444010674 Walker A motif; other site 693444010675 ATP binding site [chemical binding]; other site 693444010676 Walker B motif; other site 693444010677 arginine finger; other site 693444010678 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 693444010679 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 693444010680 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 693444010681 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693444010682 Walker A motif; other site 693444010683 ATP binding site [chemical binding]; other site 693444010684 Walker B motif; other site 693444010685 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 693444010686 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 693444010687 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 693444010688 oligomer interface [polypeptide binding]; other site 693444010689 active site residues [active] 693444010690 trigger factor; Provisional; Region: tig; PRK01490 693444010691 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 693444010692 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 693444010693 transcriptional regulator BolA; Provisional; Region: PRK11628 693444010694 hypothetical protein; Provisional; Region: PRK11627 693444010695 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 693444010696 Uncharacterized lipoprotein; Region: Lipoprotein_16; pfam03923 693444010697 muropeptide transporter; Reviewed; Region: ampG; PRK11902 693444010698 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693444010699 putative substrate translocation pore; other site 693444010700 cytochrome o ubiquinol oxidase subunit II; Provisional; Region: PRK10525 693444010701 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 693444010702 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 693444010703 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 693444010704 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 693444010705 D-pathway; other site 693444010706 Putative ubiquinol binding site [chemical binding]; other site 693444010707 Low-spin heme (heme b) binding site [chemical binding]; other site 693444010708 Putative water exit pathway; other site 693444010709 Binuclear center (heme o3/CuB) [ion binding]; other site 693444010710 K-pathway; other site 693444010711 Putative proton exit pathway; other site 693444010712 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 693444010713 Subunit I/III interface [polypeptide binding]; other site 693444010714 Subunit III/IV interface [polypeptide binding]; other site 693444010715 cytochrome o ubiquinol oxidase subunit IV; Provisional; Region: PRK10582 693444010716 protoheme IX farnesyltransferase; Provisional; Region: PRK13362 693444010717 UbiA prenyltransferase family; Region: UbiA; pfam01040 693444010718 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 693444010719 Sel1-like repeats; Region: SEL1; smart00671 693444010720 Sel1-like repeats; Region: SEL1; smart00671 693444010721 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 693444010722 TPR motif; other site 693444010723 binding surface 693444010724 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 693444010725 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 693444010726 Bacterial transcriptional regulator; Region: IclR; pfam01614 693444010727 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 693444010728 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 693444010729 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 693444010730 shikimate binding site; other site 693444010731 NAD(P) binding site [chemical binding]; other site 693444010732 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12843 693444010733 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 693444010734 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 693444010735 NIPSNAP; Region: NIPSNAP; pfam07978 693444010736 putative FAD-binding dehydrogenase; Reviewed; Region: PRK06134 693444010737 Predicted oxidoreductase [General function prediction only]; Region: COG3573 693444010738 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 693444010739 benzoate transport; Region: 2A0115; TIGR00895 693444010740 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693444010741 putative substrate translocation pore; other site 693444010742 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693444010743 putative substrate translocation pore; other site 693444010744 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 693444010745 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 693444010746 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 693444010747 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693444010748 Major Facilitator Superfamily; Region: MFS_1; pfam07690 693444010749 putative substrate translocation pore; other site 693444010750 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 693444010751 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 693444010752 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 693444010753 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 693444010754 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 693444010755 oxidative-stress-resistance chaperone; Provisional; Region: PRK11574 693444010756 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 693444010757 conserved cys residue [active] 693444010758 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 693444010759 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 693444010760 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 693444010761 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 693444010762 NAD binding site [chemical binding]; other site 693444010763 sugar binding site [chemical binding]; other site 693444010764 divalent metal binding site [ion binding]; other site 693444010765 tetramer (dimer of dimers) interface [polypeptide binding]; other site 693444010766 dimer interface [polypeptide binding]; other site 693444010767 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 693444010768 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 693444010769 active site 693444010770 trimer interface [polypeptide binding]; other site 693444010771 allosteric site; other site 693444010772 active site lid [active] 693444010773 hexamer (dimer of trimers) interface [polypeptide binding]; other site 693444010774 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 693444010775 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 693444010776 DNA-binding site [nucleotide binding]; DNA binding site 693444010777 UTRA domain; Region: UTRA; pfam07702 693444010778 tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269 693444010779 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 693444010780 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 693444010781 Ligand Binding Site [chemical binding]; other site 693444010782 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 693444010783 active site residue [active] 693444010784 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 693444010785 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 693444010786 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 693444010787 substrate binding pocket [chemical binding]; other site 693444010788 chain length determination region; other site 693444010789 substrate-Mg2+ binding site; other site 693444010790 catalytic residues [active] 693444010791 aspartate-rich region 1; other site 693444010792 active site lid residues [active] 693444010793 aspartate-rich region 2; other site 693444010794 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 693444010795 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 693444010796 TPP-binding site; other site 693444010797 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 693444010798 PYR/PP interface [polypeptide binding]; other site 693444010799 dimer interface [polypeptide binding]; other site 693444010800 TPP binding site [chemical binding]; other site 693444010801 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 693444010802 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 693444010803 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 693444010804 active site 693444010805 catalytic tetrad [active] 693444010806 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 693444010807 tetramer interfaces [polypeptide binding]; other site 693444010808 binuclear metal-binding site [ion binding]; other site 693444010809 thiamine monophosphate kinase; Provisional; Region: PRK05731 693444010810 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 693444010811 ATP binding site [chemical binding]; other site 693444010812 dimerization interface [polypeptide binding]; other site 693444010813 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 693444010814 putative RNA binding site [nucleotide binding]; other site 693444010815 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 693444010816 homopentamer interface [polypeptide binding]; other site 693444010817 active site 693444010818 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 693444010819 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 693444010820 catalytic motif [active] 693444010821 Zn binding site [ion binding]; other site 693444010822 riboflavin-specific deaminase C-terminal domain; Region: ribD_Cterm; TIGR00227 693444010823 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 693444010824 ATP cone domain; Region: ATP-cone; pfam03477 693444010825 hypothetical protein; Provisional; Region: PRK11530 693444010826 nucleoside-specific channel-forming protein Tsx; Provisional; Region: PRK15106 693444010827 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 693444010828 active site 693444010829 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 693444010830 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 693444010831 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 693444010832 active site 693444010833 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 693444010834 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 693444010835 Protein export membrane protein; Region: SecD_SecF; pfam02355 693444010836 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 693444010837 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 693444010838 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 693444010839 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 693444010840 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 693444010841 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 693444010842 tRNA-guanine family transglycosylase; Region: tgt_general; TIGR00449 693444010843 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 693444010844 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 693444010845 acyl carrier protein phosphodiesterase; Provisional; Region: PRK10045 693444010846 peroxidase; Provisional; Region: PRK15000 693444010847 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 693444010848 dimer interface [polypeptide binding]; other site 693444010849 decamer (pentamer of dimers) interface [polypeptide binding]; other site 693444010850 catalytic triad [active] 693444010851 peroxidatic and resolving cysteines [active] 693444010852 Protein of unknown function (DUF3999); Region: DUF3999; pfam13163 693444010853 Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101 693444010854 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 693444010855 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 693444010856 active site 693444010857 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224 693444010858 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 693444010859 Isochorismatase family; Region: Isochorismatase; pfam00857 693444010860 catalytic triad [active] 693444010861 dimer interface [polypeptide binding]; other site 693444010862 conserved cis-peptide bond; other site 693444010863 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693444010864 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 693444010865 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 693444010866 dimerization interface [polypeptide binding]; other site 693444010867 maltodextrin glucosidase; Provisional; Region: PRK10785 693444010868 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 693444010869 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 693444010870 active site 693444010871 homodimer interface [polypeptide binding]; other site 693444010872 catalytic site [active] 693444010873 putative proline-specific permease; Provisional; Region: proY; PRK10580 693444010874 Spore germination protein; Region: Spore_permease; cl17796 693444010875 branched-chain amino acid transport system 2 carrier protein BrnQ; Provisional; Region: PRK15433 693444010876 phosphate regulon sensor protein; Provisional; Region: phoR; PRK11006 693444010877 Domain of unknown function (DUF3329); Region: DUF3329; pfam11808 693444010878 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 693444010879 putative active site [active] 693444010880 heme pocket [chemical binding]; other site 693444010881 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 693444010882 dimer interface [polypeptide binding]; other site 693444010883 phosphorylation site [posttranslational modification] 693444010884 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693444010885 ATP binding site [chemical binding]; other site 693444010886 Mg2+ binding site [ion binding]; other site 693444010887 G-X-G motif; other site 693444010888 transcriptional regulator PhoB; Provisional; Region: PRK10161 693444010889 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693444010890 active site 693444010891 phosphorylation site [posttranslational modification] 693444010892 intermolecular recognition site; other site 693444010893 dimerization interface [polypeptide binding]; other site 693444010894 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 693444010895 DNA binding site [nucleotide binding] 693444010896 exonuclease subunit SbcD; Provisional; Region: PRK10966 693444010897 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 693444010898 active site 693444010899 metal binding site [ion binding]; metal-binding site 693444010900 DNA binding site [nucleotide binding] 693444010901 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 693444010902 exonuclease subunit SbcC; Provisional; Region: PRK10246 693444010903 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693444010904 Walker A/P-loop; other site 693444010905 ATP binding site [chemical binding]; other site 693444010906 Q-loop/lid; other site 693444010907 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693444010908 ABC transporter signature motif; other site 693444010909 Walker B; other site 693444010910 D-loop; other site 693444010911 H-loop/switch region; other site 693444010912 fructokinase; Reviewed; Region: PRK09557 693444010913 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 693444010914 nucleotide binding site [chemical binding]; other site 693444010915 recombination associated protein; Reviewed; Region: rdgC; PRK00321 693444010916 hypothetical protein; Provisional; Region: PRK10579 693444010917 hypothetical protein; Provisional; Region: PRK10481 693444010918 hypothetical protein; Provisional; Region: PRK10380 693444010919 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 693444010920 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 693444010921 ADP binding site [chemical binding]; other site 693444010922 magnesium binding site [ion binding]; other site 693444010923 putative shikimate binding site; other site 693444010924 hypothetical protein; Validated; Region: PRK00124 693444010925 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 693444010926 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 693444010927 hypothetical protein; Provisional; Region: PRK11505 693444010928 psiF repeat; Region: PsiF_repeat; pfam07769 693444010929 psiF repeat; Region: PsiF_repeat; pfam07769 693444010930 alkaline phosphatase; Provisional; Region: PRK10518 693444010931 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 693444010932 active site 693444010933 dimer interface [polypeptide binding]; other site 693444010934 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 693444010935 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 693444010936 DNA binding site [nucleotide binding] 693444010937 domain linker motif; other site 693444010938 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 693444010939 putative dimerization interface [polypeptide binding]; other site 693444010940 putative ligand binding site [chemical binding]; other site 693444010941 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693444010942 D-galactonate transporter; Region: 2A0114; TIGR00893 693444010943 putative substrate translocation pore; other site 693444010944 gluconate 5-dehydrogenase; Provisional; Region: PRK08085 693444010945 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 693444010946 NADP binding site [chemical binding]; other site 693444010947 homodimer interface [polypeptide binding]; other site 693444010948 active site 693444010949 drug efflux system protein MdtG; Provisional; Region: PRK09874 693444010950 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693444010951 putative substrate translocation pore; other site 693444010952 Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904 693444010953 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 693444010954 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 693444010955 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 693444010956 Protein of unknown function (DUF2754); Region: DUF2754; pfam10953 693444010957 Protein of unknown function (DUF2755); Region: DUF2755; pfam10954 693444010958 Protein of unknown function (DUF1615); Region: DUF1615; pfam07759 693444010959 microcin B17 transporter; Reviewed; Region: PRK11098 693444010960 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 693444010961 beta-lactam binding protein AmpH; Provisional; Region: PRK10662 693444010962 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11832 693444010963 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 693444010964 ligand binding site [chemical binding]; other site 693444010965 flexible hinge region; other site 693444010966 Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta) domain...; Region: PL_Passenger_AT; cd00253 693444010967 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 693444010968 Autotransporter beta-domain; Region: Autotransporter; pfam03797 693444010969 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 693444010970 dimer interface [polypeptide binding]; other site 693444010971 active site 693444010972 Schiff base residues; other site 693444010973 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 693444010974 taurine dioxygenase; Reviewed; Region: tauD; PRK09553 693444010975 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 693444010976 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693444010977 dimer interface [polypeptide binding]; other site 693444010978 conserved gate region; other site 693444010979 putative PBP binding loops; other site 693444010980 ABC-ATPase subunit interface; other site 693444010981 taurine transporter ATP-binding subunit; Provisional; Region: tauB; PRK11248 693444010982 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 693444010983 Walker A/P-loop; other site 693444010984 ATP binding site [chemical binding]; other site 693444010985 Q-loop/lid; other site 693444010986 ABC transporter signature motif; other site 693444010987 Walker B; other site 693444010988 D-loop; other site 693444010989 H-loop/switch region; other site 693444010990 ABC-type taurine transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: TauA; COG4521 693444010991 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 693444010992 substrate binding pocket [chemical binding]; other site 693444010993 membrane-bound complex binding site; other site 693444010994 hinge residues; other site 693444010995 homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485 693444010996 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 693444010997 S-methylmethionine transporter; Provisional; Region: PRK11387 693444010998 Uncharacterized conserved protein [Function unknown]; Region: COG2850 693444010999 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 693444011000 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 693444011001 active site 693444011002 catalytic tetrad [active] 693444011003 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 693444011004 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 693444011005 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 693444011006 HlyD family secretion protein; Region: HlyD_3; pfam13437 693444011007 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 693444011008 Beta-lactamase; Region: Beta-lactamase; pfam00144 693444011009 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 693444011010 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 693444011011 trimer interface [polypeptide binding]; other site 693444011012 eyelet of channel; other site 693444011013 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 693444011014 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 693444011015 HlyD family secretion protein; Region: HlyD_3; pfam13437 693444011016 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 693444011017 putative active site [active] 693444011018 type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375 693444011019 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 693444011020 ATP-binding cassette domain of bacteriocin exporters, subfamily C; Region: ABCC_bacteriocin_exporters; cd03245 693444011021 Walker A/P-loop; other site 693444011022 ATP binding site [chemical binding]; other site 693444011023 Q-loop/lid; other site 693444011024 ABC transporter signature motif; other site 693444011025 Walker B; other site 693444011026 D-loop; other site 693444011027 H-loop/switch region; other site 693444011028 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 693444011029 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 693444011030 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 693444011031 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 693444011032 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 693444011033 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 693444011034 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 693444011035 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 693444011036 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 693444011037 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 693444011038 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 693444011039 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 693444011040 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 693444011041 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 693444011042 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 693444011043 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 693444011044 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 693444011045 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 693444011046 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 693444011047 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 693444011048 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 693444011049 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 693444011050 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 693444011051 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 693444011052 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 693444011053 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 693444011054 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 693444011055 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 693444011056 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 693444011057 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 693444011058 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 693444011059 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 693444011060 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 693444011061 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 693444011062 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 693444011063 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 693444011064 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 693444011065 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 693444011066 Family description; Region: VCBS; pfam13517 693444011067 type I secretion C-terminal target domain (VC_A0849 subclass); Region: T1SS_VCA0849; TIGR03661 693444011068 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 693444011069 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 693444011070 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693444011071 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 693444011072 dimerization interface [polypeptide binding]; other site 693444011073 benzoate transport; Region: 2A0115; TIGR00895 693444011074 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693444011075 putative substrate translocation pore; other site 693444011076 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693444011077 PilZ domain; Region: PilZ; pfam07238 693444011078 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 693444011079 fimbrial chaperone protein PegB; Provisional; Region: PRK15218 693444011080 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 693444011081 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 693444011082 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 693444011083 PapC N-terminal domain; Region: PapC_N; pfam13954 693444011084 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 693444011085 PapC C-terminal domain; Region: PapC_C; pfam13953 693444011086 Fimbrial protein; Region: Fimbrial; pfam00419 693444011087 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 693444011088 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 693444011089 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 693444011090 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 693444011091 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 693444011092 N-terminal plug; other site 693444011093 ligand-binding site [chemical binding]; other site 693444011094 Hemin uptake protein hemP; Region: hemP; cl10043 693444011095 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 693444011096 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 693444011097 N-terminal plug; other site 693444011098 ligand-binding site [chemical binding]; other site 693444011099 Putative heme degradation protein [Inorganic ion transport and metabolism]; Region: HemS; COG3720 693444011100 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 693444011101 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 693444011102 Hemin binding protein HutB. These proteins have been shown to function as initial receptors in ABC transport of hemin and hemoproteins in many eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a...; Region: HutB; cd01149 693444011103 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 693444011104 putative hemin binding site; other site 693444011105 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 693444011106 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 693444011107 ABC-ATPase subunit interface; other site 693444011108 dimer interface [polypeptide binding]; other site 693444011109 putative PBP binding regions; other site 693444011110 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 693444011111 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 693444011112 Walker A/P-loop; other site 693444011113 ATP binding site [chemical binding]; other site 693444011114 Q-loop/lid; other site 693444011115 ABC transporter signature motif; other site 693444011116 Walker B; other site 693444011117 D-loop; other site 693444011118 H-loop/switch region; other site 693444011119 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 693444011120 putative lipoprotein/autotransporter domain-containing protein; Provisional; Region: PRK14849 693444011121 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 693444011122 Autotransporter beta-domain; Region: Autotransporter; pfam03797 693444011123 Protein of unknown function (DUF1398); Region: DUF1398; cl11576 693444011124 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 693444011125 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 693444011126 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 693444011127 active site 693444011128 phosphorylation site [posttranslational modification] 693444011129 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 693444011130 active site 693444011131 P-loop; other site 693444011132 phosphorylation site [posttranslational modification] 693444011133 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 693444011134 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 693444011135 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 693444011136 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 693444011137 substrate binding site [chemical binding]; other site 693444011138 hexamer interface [polypeptide binding]; other site 693444011139 metal binding site [ion binding]; metal-binding site 693444011140 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 693444011141 classical (c) SDRs; Region: SDR_c; cd05233 693444011142 NAD(P) binding site [chemical binding]; other site 693444011143 active site 693444011144 Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005 693444011145 tetramer interface [polypeptide binding]; other site 693444011146 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 693444011147 active site 693444011148 dipeptide/tripeptide permease B; Provisional; Region: PRK10207 693444011149 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693444011150 putative substrate translocation pore; other site 693444011151 POT family; Region: PTR2; cl17359 693444011152 Major royal jelly protein; Region: MRJP; pfam03022 693444011153 short chain dehydrogenase; Provisional; Region: PRK06701 693444011154 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 693444011155 NAD binding site [chemical binding]; other site 693444011156 metal binding site [ion binding]; metal-binding site 693444011157 active site 693444011158 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 693444011159 ArsC family; Region: ArsC; pfam03960 693444011160 catalytic residues [active] 693444011161 arsenical pump membrane protein; Provisional; Region: PRK15445 693444011162 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 693444011163 transmembrane helices; other site 693444011164 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 693444011165 dimerization interface [polypeptide binding]; other site 693444011166 putative DNA binding site [nucleotide binding]; other site 693444011167 putative Zn2+ binding site [ion binding]; other site 693444011168 General stress protein [General function prediction only]; Region: GsiB; COG3729 693444011169 YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909 693444011170 dimerization interface [polypeptide binding]; other site 693444011171 metal binding site [ion binding]; metal-binding site 693444011172 Competence-damaged protein; Region: CinA; cl00666 693444011173 Predicted membrane protein [Function unknown]; Region: COG2323 693444011174 hypothetical protein; Provisional; Region: PRK10053 693444011175 choline transport protein BetT; Provisional; Region: PRK09928 693444011176 transcriptional regulator BetI; Validated; Region: PRK00767 693444011177 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 693444011178 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 693444011179 betaine aldehyde dehydrogenase; Provisional; Region: PRK13252 693444011180 NAD+-dependent 4-trimethylaminobutyraldehyde dehydrogenase, ALDH family 9A1; Region: ALDH_F9_TMBADH; cd07090 693444011181 tetrameric interface [polypeptide binding]; other site 693444011182 NAD binding site [chemical binding]; other site 693444011183 catalytic residues [active] 693444011184 choline dehydrogenase; Validated; Region: PRK02106 693444011185 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 693444011186 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 693444011187 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 693444011188 N-terminal plug; other site 693444011189 ligand-binding site [chemical binding]; other site 693444011190 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 693444011191 putative fimbrial-like adhesin protein StcD; Provisional; Region: PRK15252 693444011192 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 693444011193 DNA binding site [nucleotide binding] 693444011194 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 693444011195 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 693444011196 Zn2+ binding site [ion binding]; other site 693444011197 Mg2+ binding site [ion binding]; other site 693444011198 PapC N-terminal domain; Region: PapC_N; pfam13954 693444011199 fimbrial outer membrane usher protein; Provisional; Region: PRK15217 693444011200 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 693444011201 PapC C-terminal domain; Region: PapC_C; pfam13953 693444011202 putative chaperone protein EcpD; Provisional; Region: PRK09926 693444011203 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 693444011204 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 693444011205 integrase; Provisional; Region: int; PHA02601 693444011206 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 693444011207 active site 693444011208 DNA binding site [nucleotide binding] 693444011209 Int/Topo IB signature motif; other site 693444011210 VbhA antitoxin and related proteins; Region: VbhA_like; cd11586 693444011211 FIC domain binding interface [polypeptide binding]; other site 693444011212 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 693444011213 dimer interface [polypeptide binding]; other site 693444011214 FMN binding site [chemical binding]; other site 693444011215 NADPH bind site [chemical binding]; other site 693444011216 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 693444011217 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 693444011218 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 693444011219 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 693444011220 glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774 693444011221 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 693444011222 dimer interface [polypeptide binding]; other site 693444011223 active site 693444011224 glycine loop; other site 693444011225 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 693444011226 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 693444011227 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 693444011228 FeS/SAM binding site; other site 693444011229 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 693444011230 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 693444011231 DNA binding site [nucleotide binding] 693444011232 fructuronate transporter; Provisional; Region: PRK10034; cl15264 693444011233 gluconate transporter; Region: gntP; TIGR00791 693444011234 mannonate dehydratase; Provisional; Region: PRK03906 693444011235 mannonate dehydratase; Region: uxuA; TIGR00695 693444011236 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; cl01503 693444011237 conjugal transfer protein TrbJ; Provisional; Region: PRK13879 693444011238 conjugal transfer relaxosome component TraJ; Provisional; Region: PRK13877 693444011239 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 693444011240 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 693444011241 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 693444011242 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 693444011243 AzlC protein; Region: AzlC; cl00570 693444011244 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693444011245 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693444011246 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 693444011247 dimerization interface [polypeptide binding]; other site 693444011248 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 693444011249 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 693444011250 Coenzyme A binding pocket [chemical binding]; other site 693444011251 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 693444011252 Coenzyme A binding pocket [chemical binding]; other site 693444011253 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 693444011254 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 693444011255 non-specific DNA binding site [nucleotide binding]; other site 693444011256 salt bridge; other site 693444011257 sequence-specific DNA binding site [nucleotide binding]; other site 693444011258 Cupin domain; Region: Cupin_2; pfam07883 693444011259 Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382 693444011260 B3/4 domain; Region: B3_4; pfam03483 693444011261 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 693444011262 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 693444011263 inhibitor site; inhibition site 693444011264 active site 693444011265 dimer interface [polypeptide binding]; other site 693444011266 catalytic residue [active] 693444011267 Winged helix-turn helix; Region: HTH_29; pfam13551 693444011268 Helix-turn-helix domain; Region: HTH_28; pfam13518 693444011269 Cache domain; Region: Cache_1; pfam02743 693444011270 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 693444011271 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693444011272 metal binding site [ion binding]; metal-binding site 693444011273 active site 693444011274 I-site; other site 693444011275 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 693444011276 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 693444011277 active site 693444011278 metal binding site [ion binding]; metal-binding site 693444011279 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553 693444011280 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 693444011281 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 693444011282 putative catalytic cysteine [active] 693444011283 gamma-glutamyl kinase; Provisional; Region: PRK05429 693444011284 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 693444011285 nucleotide binding site [chemical binding]; other site 693444011286 homotetrameric interface [polypeptide binding]; other site 693444011287 putative phosphate binding site [ion binding]; other site 693444011288 putative allosteric binding site; other site 693444011289 PUA domain; Region: PUA; pfam01472 693444011290 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 693444011291 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 693444011292 trimer interface [polypeptide binding]; other site 693444011293 eyelet of channel; other site 693444011294 DNA-binding transcriptional regulator Crl; Provisional; Region: PRK10984 693444011295 fermentation/respiration switch protein; Reviewed; Region: frsA; PRK05077 693444011296 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 693444011297 active site 693444011298 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 693444011299 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 693444011300 metal binding site [ion binding]; metal-binding site 693444011301 dimer interface [polypeptide binding]; other site 693444011302 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 693444011303 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 693444011304 Coenzyme A binding pocket [chemical binding]; other site 693444011305 putative antitoxin of the YafO-YafN toxin-antitoxin system; Provisional; Region: PRK09778 693444011306 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 693444011307 active site 693444011308 DNA polymerase IV; Validated; Region: PRK02406 693444011309 DNA binding site [nucleotide binding] 693444011310 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2991 693444011311 Na(+)-translocating NADH-quinone reductase subunit F; Provisional; Region: PRK05464 693444011312 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 693444011313 catalytic loop [active] 693444011314 iron binding site [ion binding]; other site 693444011315 Na+-translocating NADH:quinone oxidoreductase (Na+-NQR) FAD/NADH binding domain. (Na+-NQR) provides a means of storing redox reaction energy via the transmembrane translocation of Na2+ ions. The C-terminal domain resembles ferredoxin:NADP+ oxidoreductase; Region: NADH_quinone_reductase; cd06188 693444011316 FAD binding pocket [chemical binding]; other site 693444011317 FAD binding motif [chemical binding]; other site 693444011318 phosphate binding motif [ion binding]; other site 693444011319 beta-alpha-beta structure motif; other site 693444011320 NAD binding pocket [chemical binding]; other site 693444011321 Na(+)-translocating NADH-quinone reductase subunit E; Provisional; Region: PRK02830 693444011322 Na(+)-translocating NADH-quinone reductase subunit D; Validated; Region: PRK09292 693444011323 Na(+)-translocating NADH-quinone reductase subunit C; Provisional; Region: PRK05346 693444011324 NADH:ubiquinone oxidoreductase, Na(+)-translocating, C subunit; Region: nqrC; TIGR01938 693444011325 Na(+)-translocating NADH-quinone reductase subunit B; Provisional; Region: PRK05349 693444011326 Na(+)-translocating NADH-quinone reductase subunit A; Provisional; Region: PRK05352 693444011327 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 693444011328 E3 interaction surface; other site 693444011329 lipoyl attachment site [posttranslational modification]; other site 693444011330 NQRA C-terminal domain; Region: NQRA_SLBB; pfam11973 693444011331 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 693444011332 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 693444011333 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 693444011334 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 693444011335 putative active site [active] 693444011336 putative dimer interface [polypeptide binding]; other site 693444011337 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 693444011338 dimer interface [polypeptide binding]; other site 693444011339 active site 693444011340 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 693444011341 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 693444011342 active site 693444011343 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 693444011344 C-lysozyme inhibitor; Provisional; Region: PRK09993 693444011345 C-N hydrolase family amidase; Provisional; Region: PRK10438 693444011346 Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575 693444011347 putative active site [active] 693444011348 catalytic triad [active] 693444011349 dimer interface [polypeptide binding]; other site 693444011350 multimer interface [polypeptide binding]; other site 693444011351 Uncharacterized conserved protein (DUF2235); Region: DUF2235; pfam09994 693444011352 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 693444011353 Protein of unknown function (DUF3304); Region: DUF3304; pfam11745 693444011354 Protein of unknown function (DUF3304); Region: DUF3304; pfam11745 693444011355 Domain of unknown function (DUF4123); Region: DUF4123; pfam13503 693444011356 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 693444011357 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 693444011358 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 693444011359 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 693444011360 Protein of unknown function (DUF770); Region: DUF770; pfam05591 693444011361 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517; cl05484 693444011362 Protein of unknown function (DUF877); Region: DUF877; pfam05943 693444011363 type VI secretion system lysozyme-like protein; Region: VI_zyme; TIGR03357 693444011364 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 693444011365 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 693444011366 type VI secretion protein, VC_A0111 family; Region: VI_chp_1; TIGR03347 693444011367 Predicted component of the type VI protein secretion system, contains a FHA domain [Intracellular trafficking, secretion, and vesicular transport; Signal transduction mechanisms]; Region: COG3456 693444011368 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062 693444011369 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3521 693444011370 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3522 693444011371 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 693444011372 Type VI protein secretion system component VasF [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3455 693444011373 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 693444011374 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693444011375 Walker A motif; other site 693444011376 ATP binding site [chemical binding]; other site 693444011377 Walker B motif; other site 693444011378 arginine finger; other site 693444011379 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693444011380 Walker A motif; other site 693444011381 ATP binding site [chemical binding]; other site 693444011382 Walker B motif; other site 693444011383 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 693444011384 type VI secretion-associated protein, VC_A0118 family; Region: VI_minor_1; TIGR03360 693444011385 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3515 693444011386 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 693444011387 type VI secretion-associated protein, VC_A0119 family; Region: VI_chp_7; TIGR03362 693444011388 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3515 693444011389 Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and vesicular transport]; Region: IcmF; COG3523 693444011390 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 693444011391 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 693444011392 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 693444011393 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3515 693444011394 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 693444011395 Domain of unknown function (DUF4010); Region: DUF4010; pfam13194 693444011396 ImpA domain protein; Region: DUF3702; pfam12486 693444011397 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 693444011398 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 693444011399 active site 693444011400 catalytic site [active] 693444011401 substrate binding site [chemical binding]; other site 693444011402 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 693444011403 RNA/DNA hybrid binding site [nucleotide binding]; other site 693444011404 active site 693444011405 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693444011406 hydroxyacylglutathione hydrolase; Provisional; Region: PRK10241 693444011407 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 693444011408 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 693444011409 N-acetyl-D-glucosamine binding site [chemical binding]; other site 693444011410 catalytic residue [active] 693444011411 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 693444011412 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 693444011413 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693444011414 S-adenosylmethionine binding site [chemical binding]; other site 693444011415 hypothetical protein; Provisional; Region: PRK05421 693444011416 putative catalytic site [active] 693444011417 putative metal binding site [ion binding]; other site 693444011418 putative phosphate binding site [ion binding]; other site 693444011419 putative catalytic site [active] 693444011420 putative phosphate binding site [ion binding]; other site 693444011421 putative metal binding site [ion binding]; other site 693444011422 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 693444011423 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693444011424 putative substrate translocation pore; other site 693444011425 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693444011426 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693444011427 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 693444011428 dimerization interface [polypeptide binding]; other site 693444011429 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 693444011430 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 693444011431 active site 693444011432 catalytic tetrad [active] 693444011433 D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942 693444011434 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 693444011435 active site 693444011436 motif I; other site 693444011437 motif II; other site 693444011438 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 693444011439 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 693444011440 Walker A/P-loop; other site 693444011441 ATP binding site [chemical binding]; other site 693444011442 Q-loop/lid; other site 693444011443 ABC transporter signature motif; other site 693444011444 Walker B; other site 693444011445 D-loop; other site 693444011446 H-loop/switch region; other site 693444011447 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 693444011448 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693444011449 dimer interface [polypeptide binding]; other site 693444011450 conserved gate region; other site 693444011451 ABC-ATPase subunit interface; other site 693444011452 DL-methionine transporter substrate-binding subunit; Provisional; Region: metQ; PRK11063 693444011453 lipoprotein, YaeC family; Region: TIGR00363 693444011454 outer membrane lipoprotein; Reviewed; Region: rcsF; PRK10781 693444011455 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 693444011456 homodimer interaction site [polypeptide binding]; other site 693444011457 cofactor binding site; other site 693444011458 prolyl-tRNA synthetase; Provisional; Region: PRK09194 693444011459 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 693444011460 dimer interface [polypeptide binding]; other site 693444011461 motif 1; other site 693444011462 active site 693444011463 motif 2; other site 693444011464 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 693444011465 putative deacylase active site [active] 693444011466 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 693444011467 active site 693444011468 motif 3; other site 693444011469 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 693444011470 anticodon binding site; other site 693444011471 lipoprotein involved with copper homeostasis and adhesion; Provisional; Region: PRK10523 693444011472 NlpE N-terminal domain; Region: NlpE; pfam04170 693444011473 hypothetical protein; Provisional; Region: PRK09256 693444011474 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 693444011475 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4681 693444011476 hypothetical protein; Provisional; Region: PRK04964 693444011477 Rho-binding antiterminator; Provisional; Region: PRK11625 693444011478 tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660 693444011479 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 693444011480 Ligand Binding Site [chemical binding]; other site 693444011481 TilS substrate binding domain; Region: TilS; pfam09179 693444011482 TilS substrate C-terminal domain; Region: TilS_C; pfam11734 693444011483 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 693444011484 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 693444011485 putative metal binding site [ion binding]; other site 693444011486 lysine decarboxylase LdcC; Provisional; Region: PRK15399 693444011487 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 693444011488 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 693444011489 homodimer interface [polypeptide binding]; other site 693444011490 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693444011491 catalytic residue [active] 693444011492 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 693444011493 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 693444011494 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 693444011495 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 693444011496 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 693444011497 putative active site [active] 693444011498 putative PHP Thumb interface [polypeptide binding]; other site 693444011499 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 693444011500 generic binding surface II; other site 693444011501 generic binding surface I; other site 693444011502 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 693444011503 RNA/DNA hybrid binding site [nucleotide binding]; other site 693444011504 active site 693444011505 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 693444011506 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 693444011507 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 693444011508 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 693444011509 active site 693444011510 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 693444011511 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 693444011512 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 693444011513 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 693444011514 trimer interface [polypeptide binding]; other site 693444011515 active site 693444011516 UDP-GlcNAc binding site [chemical binding]; other site 693444011517 lipid binding site [chemical binding]; lipid-binding site 693444011518 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 693444011519 periplasmic chaperone; Provisional; Region: PRK10780 693444011520 outer membrane protein assembly factor YaeT; Provisional; Region: PRK11067 693444011521 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 693444011522 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 693444011523 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 693444011524 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 693444011525 Surface antigen; Region: Bac_surface_Ag; pfam01103 693444011526 zinc metallopeptidase RseP; Provisional; Region: PRK10779 693444011527 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 693444011528 active site 693444011529 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 693444011530 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 693444011531 protein binding site [polypeptide binding]; other site 693444011532 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 693444011533 putative substrate binding region [chemical binding]; other site 693444011534 CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624 693444011535 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 693444011536 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 693444011537 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 693444011538 catalytic residue [active] 693444011539 putative FPP diphosphate binding site; other site 693444011540 putative FPP binding hydrophobic cleft; other site 693444011541 dimer interface [polypeptide binding]; other site 693444011542 putative IPP diphosphate binding site; other site 693444011543 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 693444011544 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 693444011545 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 693444011546 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 693444011547 ribosome recycling factor; Reviewed; Region: frr; PRK00083 693444011548 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 693444011549 hinge region; other site 693444011550 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 693444011551 putative nucleotide binding site [chemical binding]; other site 693444011552 uridine monophosphate binding site [chemical binding]; other site 693444011553 homohexameric interface [polypeptide binding]; other site 693444011554 elongation factor Ts; Provisional; Region: tsf; PRK09377 693444011555 UBA/TS-N domain; Region: UBA; pfam00627 693444011556 Elongation factor TS; Region: EF_TS; pfam00889 693444011557 Elongation factor TS; Region: EF_TS; pfam00889 693444011558 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 693444011559 rRNA interaction site [nucleotide binding]; other site 693444011560 S8 interaction site; other site 693444011561 putative laminin-1 binding site; other site 693444011562 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 693444011563 active site 693444011564 PII uridylyl-transferase; Provisional; Region: PRK05007 693444011565 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 693444011566 metal binding triad; other site 693444011567 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 693444011568 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 693444011569 Zn2+ binding site [ion binding]; other site 693444011570 Mg2+ binding site [ion binding]; other site 693444011571 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 693444011572 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 693444011573 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 693444011574 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 693444011575 trimer interface [polypeptide binding]; other site 693444011576 active site 693444011577 substrate binding site [chemical binding]; other site 693444011578 CoA binding site [chemical binding]; other site 693444011579 hypothetical protein; Provisional; Region: PRK13677 693444011580 carbohydrate diacid transcriptional activator CdaR; Provisional; Region: PRK11477 693444011581 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 693444011582 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 693444011583 serine endoprotease; Provisional; Region: PRK10942 693444011584 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 693444011585 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 693444011586 protein binding site [polypeptide binding]; other site 693444011587 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 693444011588 deoxyguanosinetriphosphate triphosphohydrolase; Provisional; Region: dgt; PRK04926 693444011589 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 693444011590 Zn2+ binding site [ion binding]; other site 693444011591 Mg2+ binding site [ion binding]; other site 693444011592 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 693444011593 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 693444011594 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 693444011595 vitamin B12-transporter protein BtuF; Provisional; Region: PRK03379 693444011596 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 693444011597 cobalamin binding residues [chemical binding]; other site 693444011598 putative BtuC binding residues; other site 693444011599 dimer interface [polypeptide binding]; other site 693444011600 hypothetical protein; Provisional; Region: PRK10578 693444011601 UPF0126 domain; Region: UPF0126; pfam03458 693444011602 UPF0126 domain; Region: UPF0126; pfam03458 693444011603 Protein of unknown function (DUF3617); Region: DUF3617; pfam12276 693444011604 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 693444011605 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 693444011606 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 693444011607 Cl- selectivity filter; other site 693444011608 Cl- binding residues [ion binding]; other site 693444011609 pore gating glutamate residue; other site 693444011610 dimer interface [polypeptide binding]; other site 693444011611 H+/Cl- coupling transport residue; other site 693444011612 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 693444011613 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 693444011614 inhibitor-cofactor binding pocket; inhibition site 693444011615 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693444011616 catalytic residue [active] 693444011617 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 693444011618 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 693444011619 ABC-ATPase subunit interface; other site 693444011620 dimer interface [polypeptide binding]; other site 693444011621 putative PBP binding regions; other site 693444011622 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 693444011623 ABC-ATPase subunit interface; other site 693444011624 dimer interface [polypeptide binding]; other site 693444011625 putative PBP binding regions; other site 693444011626 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 693444011627 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 693444011628 siderophore binding site; other site 693444011629 iron-hydroxamate transporter ATP-binding subunit; Provisional; Region: PRK10575 693444011630 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 693444011631 Walker A/P-loop; other site 693444011632 ATP binding site [chemical binding]; other site 693444011633 Q-loop/lid; other site 693444011634 ABC transporter signature motif; other site 693444011635 Walker B; other site 693444011636 D-loop; other site 693444011637 H-loop/switch region; other site 693444011638 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 693444011639 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 693444011640 N-terminal plug; other site 693444011641 ligand-binding site [chemical binding]; other site 693444011642 bifunctional glycosyl transferase/transpeptidase; Reviewed; Region: mrcB; PRK09506 693444011643 Transglycosylase; Region: Transgly; pfam00912 693444011644 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 693444011645 ATP-dependent RNA helicase HrpB; Provisional; Region: PRK11664 693444011646 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 693444011647 ATP binding site [chemical binding]; other site 693444011648 putative Mg++ binding site [ion binding]; other site 693444011649 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 693444011650 nucleotide binding region [chemical binding]; other site 693444011651 ATP-binding site [chemical binding]; other site 693444011652 Helicase associated domain (HA2) Add an annotation; Region: HA2; smart00847 693444011653 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 693444011654 2'-5' RNA ligase; Provisional; Region: PRK15124 693444011655 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 693444011656 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 693444011657 RNA polymerase-binding transcription factor; Provisional; Region: dksA; PRK10778 693444011658 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 693444011659 tRNA synthetases class I (E and Q), catalytic domain; Region: tRNA-synt_1c; pfam00749 693444011660 active site 693444011661 HIGH motif; other site 693444011662 nucleotide binding site [chemical binding]; other site 693444011663 KMSKS motif; other site 693444011664 poly(A) polymerase I; Provisional; Region: pcnB; PRK11623 693444011665 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 693444011666 active site 693444011667 NTP binding site [chemical binding]; other site 693444011668 metal binding triad [ion binding]; metal-binding site 693444011669 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 693444011670 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 693444011671 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 693444011672 catalytic center binding site [active] 693444011673 ATP binding site [chemical binding]; other site 693444011674 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 693444011675 oligomerization interface [polypeptide binding]; other site 693444011676 active site 693444011677 metal binding site [ion binding]; metal-binding site 693444011678 pantoate--beta-alanine ligase; Region: panC; TIGR00018 693444011679 Pantoate-beta-alanine ligase; Region: PanC; cd00560 693444011680 active site 693444011681 ATP-binding site [chemical binding]; other site 693444011682 pantoate-binding site; other site 693444011683 HXXH motif; other site 693444011684 putative transposase; Provisional; Region: PRK09857 693444011685 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 693444011686 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 693444011687 tetramerization interface [polypeptide binding]; other site 693444011688 active site 693444011689 Putative catalytic polysaccharide deacetylase domain of uncharacterized protein yadE and similar proteins; Region: CE4_yadE_5s; cd10966 693444011690 putative active site [active] 693444011691 putative metal binding site [ion binding]; other site 693444011692 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 693444011693 active pocket/dimerization site; other site 693444011694 active site 693444011695 phosphorylation site [posttranslational modification] 693444011696 inner membrane transport permease; Provisional; Region: PRK15066 693444011697 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 693444011698 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 693444011699 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 693444011700 Walker A/P-loop; other site 693444011701 ATP binding site [chemical binding]; other site 693444011702 Q-loop/lid; other site 693444011703 ABC transporter signature motif; other site 693444011704 Walker B; other site 693444011705 D-loop; other site 693444011706 H-loop/switch region; other site 693444011707 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 693444011708 active site clefts [active] 693444011709 zinc binding site [ion binding]; other site 693444011710 dimer interface [polypeptide binding]; other site 693444011711 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 693444011712 active site 693444011713 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 693444011714 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 693444011715 Trp docking motif [polypeptide binding]; other site 693444011716 putative active site [active] 693444011717 multicopper oxidase; Provisional; Region: PRK10965 693444011718 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 693444011719 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 693444011720 Bacterial chaperone lipoprotein (PulS_OutS); Region: PulS_OutS; cl09898 693444011721 spermidine synthase; Provisional; Region: PRK00811 693444011722 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693444011723 S-adenosylmethionine binding site [chemical binding]; other site 693444011724 S-adenosylmethionine decarboxylase; Provisional; Region: PRK05462 693444011725 LacY proton/sugar symporter; Region: LacY_symp; pfam01306 693444011726 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693444011727 putative substrate translocation pore; other site 693444011728 beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525 693444011729 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 693444011730 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 693444011731 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 693444011732 Beta galactosidase small chain; Region: Bgal_small_N; pfam02929 693444011733 lac repressor; Reviewed; Region: lacI; PRK09526 693444011734 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 693444011735 DNA binding site [nucleotide binding] 693444011736 domain linker motif; other site 693444011737 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 693444011738 ligand binding site [chemical binding]; other site 693444011739 dimerization interface (open form) [polypeptide binding]; other site 693444011740 dimerization interface (closed form) [polypeptide binding]; other site 693444011741 hypothetical protein; Provisional; Region: PRK05248 693444011742 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 693444011743 short chain dehydrogenase; Provisional; Region: PRK07041 693444011744 NAD(P) binding site [chemical binding]; other site 693444011745 active site 693444011746 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 693444011747 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 693444011748 substrate binding site [chemical binding]; other site 693444011749 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 693444011750 substrate binding site [chemical binding]; other site 693444011751 ligand binding site [chemical binding]; other site 693444011752 Protein of unknown function (DUF3300); Region: DUF3300; pfam11737 693444011753 Protein of unknown function (DUF2950); Region: DUF2950; pfam11453 693444011754 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 693444011755 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 693444011756 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 693444011757 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 693444011758 pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated; Region: aceF; PRK11854 693444011759 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 693444011760 E3 interaction surface; other site 693444011761 lipoyl attachment site [posttranslational modification]; other site 693444011762 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 693444011763 E3 interaction surface; other site 693444011764 lipoyl attachment site [posttranslational modification]; other site 693444011765 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 693444011766 E3 interaction surface; other site 693444011767 lipoyl attachment site [posttranslational modification]; other site 693444011768 e3 binding domain; Region: E3_binding; pfam02817 693444011769 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 693444011770 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 693444011771 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 693444011772 dimer interface [polypeptide binding]; other site 693444011773 TPP-binding site [chemical binding]; other site 693444011774 transcriptional regulator PdhR; Reviewed; Region: pdhR; PRK09464 693444011775 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 693444011776 DNA-binding site [nucleotide binding]; DNA binding site 693444011777 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 693444011778 aromatic amino acid transporter; Provisional; Region: PRK10238 693444011779 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 693444011780 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693444011781 putative substrate translocation pore; other site 693444011782 Glycosyl hydrolase family 43; Region: GH43_1; cd08980 693444011783 active site 693444011784 regulatory protein AmpE; Provisional; Region: PRK10987 693444011785 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 693444011786 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 693444011787 amidase catalytic site [active] 693444011788 Zn binding residues [ion binding]; other site 693444011789 substrate binding site [chemical binding]; other site 693444011790 quinolinate phosphoribosyltransferase; Validated; Region: PRK09016 693444011791 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 693444011792 dimerization interface [polypeptide binding]; other site 693444011793 active site 693444011794 putative major pilin subunit; Provisional; Region: PRK10574 693444011795 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 693444011796 Pilin (bacterial filament); Region: Pilin; pfam00114 693444011797 hypothetical protein; Provisional; Region: PRK10436 693444011798 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 693444011799 Walker A motif; other site 693444011800 ATP binding site [chemical binding]; other site 693444011801 Walker B motif; other site 693444011802 type IV pilin biogenesis protein; Provisional; Region: PRK10573 693444011803 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 693444011804 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 693444011805 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05096 693444011806 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 693444011807 active site 693444011808 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 693444011809 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 693444011810 CoA-binding site [chemical binding]; other site 693444011811 ATP-binding [chemical binding]; other site 693444011812 hypothetical protein; Provisional; Region: PRK05287 693444011813 DNA gyrase inhibitor; Reviewed; Region: PRK00418 693444011814 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 693444011815 active site 693444011816 8-oxo-dGMP binding site [chemical binding]; other site 693444011817 nudix motif; other site 693444011818 metal binding site [ion binding]; metal-binding site 693444011819 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 693444011820 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 693444011821 SEC-C motif; Region: SEC-C; pfam02810 693444011822 SecA regulator SecM; Provisional; Region: PRK02943 693444011823 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 693444011824 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 693444011825 cell division protein FtsZ; Validated; Region: PRK09330 693444011826 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 693444011827 nucleotide binding site [chemical binding]; other site 693444011828 SulA interaction site; other site 693444011829 cell division protein FtsA; Reviewed; Region: ftsA; PRK09472 693444011830 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 693444011831 Cell division protein FtsA; Region: FtsA; pfam14450 693444011832 cell division protein FtsQ; Provisional; Region: PRK10775 693444011833 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 693444011834 Cell division protein FtsQ; Region: FtsQ; pfam03799 693444011835 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 693444011836 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 693444011837 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 693444011838 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 693444011839 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 693444011840 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 693444011841 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 693444011842 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 693444011843 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 693444011844 active site 693444011845 homodimer interface [polypeptide binding]; other site 693444011846 cell division protein FtsW; Provisional; Region: PRK10774 693444011847 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03806 693444011848 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 693444011849 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 693444011850 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 693444011851 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 693444011852 Mg++ binding site [ion binding]; other site 693444011853 putative catalytic motif [active] 693444011854 putative substrate binding site [chemical binding]; other site 693444011855 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed; Region: murF; PRK10773 693444011856 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 693444011857 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 693444011858 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 693444011859 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 693444011860 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 693444011861 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 693444011862 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 693444011863 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 693444011864 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 693444011865 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 693444011866 cell division protein FtsL; Provisional; Region: PRK10772 693444011867 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 693444011868 16S rRNA (cytosine(1402)-N(4))-methyltransferase; Region: TIGR00006 693444011869 mraZ protein; Region: TIGR00242 693444011870 MraZ protein; Region: MraZ; pfam02381 693444011871 MraZ protein; Region: MraZ; pfam02381 693444011872 DNA-binding transcriptional regulator FruR; Provisional; Region: PRK11303 693444011873 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 693444011874 DNA binding site [nucleotide binding] 693444011875 domain linker motif; other site 693444011876 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 693444011877 dimerization interface [polypeptide binding]; other site 693444011878 ligand binding site [chemical binding]; other site 693444011879 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 693444011880 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 693444011881 putative valine binding site [chemical binding]; other site 693444011882 dimer interface [polypeptide binding]; other site 693444011883 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 693444011884 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK07979 693444011885 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 693444011886 PYR/PP interface [polypeptide binding]; other site 693444011887 dimer interface [polypeptide binding]; other site 693444011888 TPP binding site [chemical binding]; other site 693444011889 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 693444011890 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 693444011891 TPP-binding site [chemical binding]; other site 693444011892 dimer interface [polypeptide binding]; other site 693444011893 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 693444011894 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693444011895 The C-terminal substrate binding domain of LysR-type transcriptional regulator LeuO, an activator of leucine synthesis operon, contains the type 2 periplasmic binding fold; Region: PBP2_LeuO; cd08466 693444011896 putative substrate binding pocket [chemical binding]; other site 693444011897 putative dimerization interface [polypeptide binding]; other site 693444011898 2-isopropylmalate synthase; Validated; Region: PRK00915 693444011899 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 693444011900 active site 693444011901 catalytic residues [active] 693444011902 metal binding site [ion binding]; metal-binding site 693444011903 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 693444011904 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 693444011905 tartrate dehydrogenase; Region: TTC; TIGR02089 693444011906 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 693444011907 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 693444011908 substrate binding site [chemical binding]; other site 693444011909 ligand binding site [chemical binding]; other site 693444011910 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 693444011911 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 693444011912 substrate binding site [chemical binding]; other site 693444011913 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693444011914 sugar efflux transporter; Region: 2A0120; TIGR00899 693444011915 putative substrate translocation pore; other site 693444011916 transcriptional regulator SgrR; Provisional; Region: PRK13626 693444011917 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 693444011918 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 693444011919 thiamine transporter substrate binding subunit; Provisional; Region: tbpA; PRK11205 693444011920 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 693444011921 thiamine transporter membrane protein; Reviewed; Region: thiP; PRK09433 693444011922 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693444011923 dimer interface [polypeptide binding]; other site 693444011924 conserved gate region; other site 693444011925 putative PBP binding loops; other site 693444011926 ABC-ATPase subunit interface; other site 693444011927 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693444011928 dimer interface [polypeptide binding]; other site 693444011929 conserved gate region; other site 693444011930 putative PBP binding loops; other site 693444011931 ABC-ATPase subunit interface; other site 693444011932 thiamine transporter ATP-binding subunit; Provisional; Region: thiQ; PRK10771 693444011933 ATP-binding cassette domain of the thiamine transport system; Region: ABC_ThiQ_thiamine_transporter; cd03298 693444011934 Walker A/P-loop; other site 693444011935 ATP binding site [chemical binding]; other site 693444011936 Q-loop/lid; other site 693444011937 ABC transporter signature motif; other site 693444011938 Walker B; other site 693444011939 D-loop; other site 693444011940 H-loop/switch region; other site 693444011941 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 693444011942 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 693444011943 DNA-binding transcriptional regulator AraC; Provisional; Region: PRK10572 693444011944 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 693444011945 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 693444011946 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 693444011947 ribulokinase; Provisional; Region: PRK04123 693444011948 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 693444011949 N- and C-terminal domain interface [polypeptide binding]; other site 693444011950 active site 693444011951 MgATP binding site [chemical binding]; other site 693444011952 catalytic site [active] 693444011953 metal binding site [ion binding]; metal-binding site 693444011954 carbohydrate binding site [chemical binding]; other site 693444011955 homodimer interface [polypeptide binding]; other site 693444011956 L-arabinose isomerase; Provisional; Region: PRK02929 693444011957 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 693444011958 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 693444011959 trimer interface [polypeptide binding]; other site 693444011960 putative substrate binding site [chemical binding]; other site 693444011961 putative metal binding site [ion binding]; other site 693444011962 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 693444011963 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 693444011964 intersubunit interface [polypeptide binding]; other site 693444011965 active site 693444011966 Zn2+ binding site [ion binding]; other site 693444011967 DNA polymerase II; Reviewed; Region: PRK05762 693444011968 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase II and similar bacterial family-B DNA polymerases; Region: DNA_polB_II_exo; cd05784 693444011969 active site 693444011970 catalytic site [active] 693444011971 substrate binding site [chemical binding]; other site 693444011972 DNA polymerase type-II subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II; cd05537 693444011973 active site 693444011974 metal-binding site 693444011975 ATP-dependent helicase HepA; Validated; Region: PRK04914 693444011976 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 693444011977 ATP binding site [chemical binding]; other site 693444011978 putative Mg++ binding site [ion binding]; other site 693444011979 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 693444011980 nucleotide binding region [chemical binding]; other site 693444011981 ATP-binding site [chemical binding]; other site 693444011982 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 693444011983 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 693444011984 active site 693444011985 Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430 693444011986 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 693444011987 putative metal binding site [ion binding]; other site 693444011988 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 693444011989 HSP70 interaction site [polypeptide binding]; other site 693444011990 LPS assembly outer membrane complex protein LptD; Provisional; Region: PRK03761 693444011991 OstA-like protein; Region: OstA; pfam03968 693444011992 Organic solvent tolerance protein; Region: OstA_C; pfam04453 693444011993 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 693444011994 SurA N-terminal domain; Region: SurA_N; pfam09312 693444011995 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 693444011996 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 693444011997 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 693444011998 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 693444011999 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 693444012000 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 693444012001 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 693444012002 bis(5'-nucleosyl)-tetraphosphatase (symmetrical); Region: apaH; TIGR00668 693444012003 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 693444012004 active site 693444012005 metal binding site [ion binding]; metal-binding site 693444012006 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 693444012007 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 693444012008 folate binding site [chemical binding]; other site 693444012009 NADP+ binding site [chemical binding]; other site 693444012010 glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562 693444012011 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 693444012012 TrkA-N domain; Region: TrkA_N; pfam02254 693444012013 glutathione-regulated potassium-efflux system ancillary protein KefF; Provisional; Region: PRK00871 693444012014 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 693444012015 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693444012016 benzoate transport; Region: 2A0115; TIGR00895 693444012017 putative substrate translocation pore; other site 693444012018 ferredoxin-like protein FixX; Provisional; Region: PRK15449 693444012019 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 693444012020 putative oxidoreductase FixC; Provisional; Region: PRK10157 693444012021 putative electron transfer flavoprotein FixB; Provisional; Region: fixB; PRK03363 693444012022 Electron transfer flavoprotein domain; Region: ETF; smart00893 693444012023 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 693444012024 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 693444012025 Ligand binding site [chemical binding]; other site 693444012026 Electron transfer flavoprotein domain; Region: ETF; pfam01012 693444012027 L-carnitine/gamma-butyrobetaine antiporter; Provisional; Region: PRK03356 693444012028 crotonobetainyl-CoA dehydrogenase; Validated; Region: PRK03354 693444012029 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 693444012030 active site 693444012031 crotonobetainyl-CoA:carnitine CoA-transferase; Provisional; Region: PRK03525 693444012032 CoA-transferase family III; Region: CoA_transf_3; pfam02515 693444012033 putative crotonobetaine/carnitine-CoA ligase; Validated; Region: caiC; PRK08008 693444012034 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_DitJ_like; cd05934 693444012035 acyl-activating enzyme (AAE) consensus motif; other site 693444012036 putative AMP binding site [chemical binding]; other site 693444012037 putative active site [active] 693444012038 putative CoA binding site [chemical binding]; other site 693444012039 carnitinyl-CoA dehydratase; Provisional; Region: PRK03580 693444012040 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 693444012041 substrate binding site [chemical binding]; other site 693444012042 oxyanion hole (OAH) forming residues; other site 693444012043 trimer interface [polypeptide binding]; other site 693444012044 carnitine operon protein CaiE; Provisional; Region: PRK13627 693444012045 paaY-like: This group is composed by uncharacterized proteins with similarity to the protein product of the E. coli paaY gene, which is part of the paa gene cluster responsible for phenylacetic acid degradation. Proteins in this group are expected to...; Region: LbH_paaY_like; cd04745 693444012046 putative trimer interface [polypeptide binding]; other site 693444012047 putative metal binding site [ion binding]; other site 693444012048 DNA-binding transcriptional activator CaiF; Provisional; Region: PRK11476 693444012049 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 693444012050 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 693444012051 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 693444012052 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 693444012053 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 693444012054 ATP-grasp domain; Region: ATP-grasp_4; cl17255 693444012055 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 693444012056 IMP binding site; other site 693444012057 dimer interface [polypeptide binding]; other site 693444012058 interdomain contacts; other site 693444012059 partial ornithine binding site; other site 693444012060 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 693444012061 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 693444012062 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 693444012063 catalytic site [active] 693444012064 subunit interface [polypeptide binding]; other site 693444012065 Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289 693444012066 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 693444012067 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 693444012068 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 693444012069 active site 693444012070 tetramer interface [polypeptide binding]; other site 693444012071 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 693444012072 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 693444012073 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 693444012074 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 693444012075 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 693444012076 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 693444012077 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 693444012078 active site 693444012079 HIGH motif; other site 693444012080 nucleotide binding site [chemical binding]; other site 693444012081 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 693444012082 active site 693444012083 KMSKS motif; other site 693444012084 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 693444012085 tRNA binding surface [nucleotide binding]; other site 693444012086 anticodon binding site; other site 693444012087 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 693444012088 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 693444012089 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 693444012090 active site 693444012091 Riboflavin kinase; Region: Flavokinase; smart00904 693444012092 transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062 693444012093 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693444012094 The C-terminal substrate binding domain of LysR-type transcriptional activator of the nhaA gene, encoding Na+/H+ antiporter, contains the type 2 periplasmic binding fold; Region: PBP2_NhaR; cd08429 693444012095 putative dimerization interface [polypeptide binding]; other site 693444012096 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09561 693444012097 chaperone protein DnaJ; Provisional; Region: PRK10767 693444012098 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 693444012099 HSP70 interaction site [polypeptide binding]; other site 693444012100 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 693444012101 substrate binding site [polypeptide binding]; other site 693444012102 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 693444012103 Zn binding sites [ion binding]; other site 693444012104 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 693444012105 dimer interface [polypeptide binding]; other site 693444012106 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 693444012107 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 693444012108 nucleotide binding site [chemical binding]; other site 693444012109 Protein of unknown function (DUF2541); Region: DUF2541; cl08090 693444012110 hypothetical protein; Provisional; Region: PRK10236 693444012111 Domain of unknown function (DUF3944); Region: DUF3944; pfam13099 693444012112 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4735 693444012113 hypothetical protein; Provisional; Region: PRK10659 693444012114 hypothetical protein; Provisional; Region: PRK09956 693444012115 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 693444012116 metabolite-proton symporter; Region: 2A0106; TIGR00883 693444012117 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693444012118 putative substrate translocation pore; other site 693444012119 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 693444012120 MPT binding site; other site 693444012121 trimer interface [polypeptide binding]; other site 693444012122 transaldolase-like protein; Provisional; Region: PTZ00411 693444012123 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 693444012124 active site 693444012125 dimer interface [polypeptide binding]; other site 693444012126 catalytic residue [active] 693444012127 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 693444012128 Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235 693444012129 hypothetical protein; Validated; Region: PRK02101 693444012130 Protein of unknown function (DUF2502); Region: DUF2502; pfam10697 693444012131 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 693444012132 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 693444012133 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693444012134 catalytic residue [active] 693444012135 homoserine kinase; Provisional; Region: PRK01212 693444012136 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 693444012137 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 693444012138 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 693444012139 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 693444012140 putative catalytic residues [active] 693444012141 putative nucleotide binding site [chemical binding]; other site 693444012142 putative aspartate binding site [chemical binding]; other site 693444012143 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 693444012144 dimer interface [polypeptide binding]; other site 693444012145 putative threonine allosteric regulatory site; other site 693444012146 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922 693444012147 putative threonine allosteric regulatory site; other site 693444012148 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 693444012149 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 693444012150 putative RNA methyltransferase; Provisional; Region: PRK10433 693444012151 RNA methyltransferase, TrmH family, group 1; Region: rRNA_methyl_1; TIGR00050 693444012152 two-component response regulator; Provisional; Region: PRK11173 693444012153 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693444012154 active site 693444012155 phosphorylation site [posttranslational modification] 693444012156 intermolecular recognition site; other site 693444012157 dimerization interface [polypeptide binding]; other site 693444012158 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 693444012159 DNA binding site [nucleotide binding] 693444012160 Inner membrane protein involved in colicin E2 resistance [Defense mechanisms]; Region: CreD; COG4452 693444012161 sensory histidine kinase CreC; Provisional; Region: PRK11100 693444012162 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 693444012163 dimerization interface [polypeptide binding]; other site 693444012164 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 693444012165 dimer interface [polypeptide binding]; other site 693444012166 phosphorylation site [posttranslational modification] 693444012167 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693444012168 ATP binding site [chemical binding]; other site 693444012169 Mg2+ binding site [ion binding]; other site 693444012170 G-X-G motif; other site 693444012171 DNA-binding response regulator CreB; Provisional; Region: PRK11083 693444012172 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693444012173 active site 693444012174 phosphorylation site [posttranslational modification] 693444012175 intermolecular recognition site; other site 693444012176 dimerization interface [polypeptide binding]; other site 693444012177 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 693444012178 DNA binding site [nucleotide binding] 693444012179 hypothetical protein; Provisional; Region: PRK10756 693444012180 CreA protein; Region: CreA; pfam05981 693444012181 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 693444012182 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 693444012183 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 693444012184 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 693444012185 catalytic core [active] 693444012186 inosine/xanthosine triphosphatase; Reviewed; Region: PRK05074 693444012187 Trp operon repressor; Provisional; Region: PRK01381 693444012188 lytic murein transglycosylase; Provisional; Region: PRK11619 693444012189 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 693444012190 N-acetyl-D-glucosamine binding site [chemical binding]; other site 693444012191 catalytic residue [active] 693444012192 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 693444012193 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 693444012194 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 693444012195 ABC transporter; Region: ABC_tran_2; pfam12848 693444012196 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 693444012197 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 693444012198 non-specific DNA binding site [nucleotide binding]; other site 693444012199 salt bridge; other site 693444012200 bifunctional DNA-binding transcriptional repressor/ NMN adenylyltransferase; Provisional; Region: PRK08099 693444012201 sequence-specific DNA binding site [nucleotide binding]; other site 693444012202 Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional NadR-like proteins; Region: NMNAT_NadR; cd02167 693444012203 active site 693444012204 (T/H)XGH motif; other site 693444012205 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 693444012206 DNA repair protein RadA; Region: sms; TIGR00416 693444012207 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 693444012208 Walker A motif/ATP binding site; other site 693444012209 ATP binding site [chemical binding]; other site 693444012210 Walker B motif; other site 693444012211 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 693444012212 phosphoserine phosphatase; Provisional; Region: serB; PRK11133 693444012213 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 693444012214 motif II; other site 693444012215 hypothetical protein; Provisional; Region: PRK11246 693444012216 lipoate-protein ligase A; Provisional; Region: lplA; PRK03822 693444012217 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 693444012218 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 693444012219 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943 693444012220 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 693444012221 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 693444012222 phosphopentomutase; Provisional; Region: PRK05362 693444012223 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 693444012224 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 693444012225 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 693444012226 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 693444012227 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 693444012228 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 693444012229 intersubunit interface [polypeptide binding]; other site 693444012230 active site 693444012231 catalytic residue [active] 693444012232 hypothetical protein; Provisional; Region: PRK10977 693444012233 glycine radical enzyme activase, YjjW family; Region: activase_YjjW; TIGR04041 693444012234 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 693444012235 FeS/SAM binding site; other site 693444012236 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 693444012237 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 693444012238 Nucleoside recognition; Region: Gate; pfam07670 693444012239 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 693444012240 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 693444012241 active site 693444012242 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 693444012243 BON domain; Region: BON; pfam04972 693444012244 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 693444012245 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 693444012246 G1 box; other site 693444012247 putative GEF interaction site [polypeptide binding]; other site 693444012248 GTP/Mg2+ binding site [chemical binding]; other site 693444012249 Switch I region; other site 693444012250 G2 box; other site 693444012251 G3 box; other site 693444012252 Switch II region; other site 693444012253 G4 box; other site 693444012254 G5 box; other site 693444012255 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 693444012256 dUMP phosphatase; Provisional; Region: PRK09449 693444012257 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 693444012258 motif II; other site 693444012259 ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491 693444012260 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 693444012261 Coenzyme A binding pocket [chemical binding]; other site 693444012262 DNA polymerase III subunit psi; Validated; Region: PRK06856 693444012263 16S ribosomal RNA m2G1207 methyltransferase; Provisional; Region: rsmC; PRK09489 693444012264 Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468 693444012265 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693444012266 S-adenosylmethionine binding site [chemical binding]; other site 693444012267 Protein of unknown function (DUF1435); Region: DUF1435; pfam07256 693444012268 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 693444012269 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693444012270 metal binding site [ion binding]; metal-binding site 693444012271 active site 693444012272 I-site; other site 693444012273 ferric iron reductase involved in ferric hydroximate transport; Provisional; Region: PRK10647 693444012274 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 693444012275 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 693444012276 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 693444012277 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 693444012278 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 693444012279 putative deacylase active site [active] 693444012280 DNA-binding transcriptional activator BglJ; Provisional; Region: PRK11475 693444012281 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 693444012282 DNA binding residues [nucleotide binding] 693444012283 dimerization interface [polypeptide binding]; other site 693444012284 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 693444012285 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 693444012286 DNA binding residues [nucleotide binding] 693444012287 dimerization interface [polypeptide binding]; other site 693444012288 4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243 693444012289 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 693444012290 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 693444012291 Uncharacterized conserved protein [Function unknown]; Region: COG2966 693444012292 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 693444012293 hypothetical protein; Provisional; Region: PRK09917 693444012294 primosomal protein DnaI; Provisional; Region: PRK02854 693444012295 DNA replication protein DnaC; Validated; Region: PRK07952 693444012296 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693444012297 Walker A motif; other site 693444012298 ATP binding site [chemical binding]; other site 693444012299 Walker B motif; other site 693444012300 hypothetical protein; Provisional; Region: PRK11667 693444012301 phosphoglycerol transferase I; Provisional; Region: PRK03776 693444012302 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 693444012303 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 693444012304 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 693444012305 dimer interface [polypeptide binding]; other site 693444012306 ligand binding site [chemical binding]; other site 693444012307 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 693444012308 dimerization interface [polypeptide binding]; other site 693444012309 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 693444012310 dimer interface [polypeptide binding]; other site 693444012311 putative CheW interface [polypeptide binding]; other site 693444012312 Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055 693444012313 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 693444012314 DNA binding residues [nucleotide binding] 693444012315 dimerization interface [polypeptide binding]; other site 693444012316 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 693444012317 DNA binding site [nucleotide binding] 693444012318 homoprotocatechuate degradation operon regulator, HpaR; Region: HpaR; TIGR02337 693444012319 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 693444012320 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase; Provisional; Region: PRK15203 693444012321 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, N-terminal subunit; Region: HpaG-N-term; TIGR02305 693444012322 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 693444012323 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase; Region: HpaE; TIGR02299 693444012324 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 693444012325 NAD binding site [chemical binding]; other site 693444012326 catalytic residues [active] 693444012327 The Class III extradiol dioxygenase, homoprotocatechuate 2,3-dioxygenase, catalyzes the key ring cleavage step in the metabolism of homoprotocatechuate; Region: HPCD; cd07370 693444012328 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 693444012329 putative active site [active] 693444012330 putative metal binding site [ion binding]; other site 693444012331 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580 693444012332 putative substrate binding pocket [chemical binding]; other site 693444012333 trimer interface [polypeptide binding]; other site 693444012334 2-oxo-hepta-3-ene-1,7-dioic acid hydratase; Region: HpaH; TIGR02312 693444012335 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 693444012336 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693444012337 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 693444012338 putative substrate translocation pore; other site 693444012339 4-hydroxyphenylacetate catabolism regulatory protein HpaA; Region: HpaA; TIGR02297 693444012340 Cupin domain; Region: Cupin_2; pfam07883 693444012341 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 693444012342 4-hydroxyphenylacetate 3-monooxygenase, oxygenase component; Region: HpaB-2; TIGR02310 693444012343 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 693444012344 4-hydroxyphenylacetate 3-monooxygenase reductase subunit; Provisional; Region: hpaC; PRK15486 693444012345 carbon starvation protein A; Provisional; Region: PRK15015 693444012346 Carbon starvation protein CstA; Region: CstA; pfam02554 693444012347 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 693444012348 Uncharacterized small protein [Function unknown]; Region: COG2879 693444012349 putative GTP-binding protein YjiA; Provisional; Region: PRK11537 693444012350 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 693444012351 P-loop, Walker A motif; other site 693444012352 Base recognition motif; other site 693444012353 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 693444012354 Fic/DOC family; Region: Fic; pfam02661 693444012355 Uncharacterized conserved protein [Function unknown]; Region: COG1479 693444012356 Protein of unknown function DUF262; Region: DUF262; pfam03235 693444012357 Protein of unknown function DUF262; Region: DUF262; pfam03235 693444012358 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 693444012359 Uncharacterized conserved protein [Function unknown]; Region: COG3586 693444012360 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 693444012361 HsdM N-terminal domain; Region: HsdM_N; pfam12161 693444012362 Methyltransferase domain; Region: Methyltransf_26; pfam13659 693444012363 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 693444012364 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 693444012365 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520 693444012366 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 693444012367 DEAD-like helicases superfamily; Region: DEXDc; smart00487 693444012368 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 693444012369 ATP binding site [chemical binding]; other site 693444012370 putative Mg++ binding site [ion binding]; other site 693444012371 endoribonuclease SymE; Provisional; Region: PRK13605 693444012372 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 693444012373 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 693444012374 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 693444012375 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 693444012376 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 693444012377 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 693444012378 NAD(P) binding site [chemical binding]; other site 693444012379 catalytic residues [active] 693444012380 Predicted membrane protein [Function unknown]; Region: COG2733 693444012381 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 693444012382 Protein of unknown function (DUF2955); Region: DUF2955; pfam11168 693444012383 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 693444012384 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 693444012385 HlyD family secretion protein; Region: HlyD_3; pfam13437 693444012386 MarR family; Region: MarR_2; cl17246 693444012387 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 693444012388 Uncharacterized conserved small protein [Function unknown]; Region: COG5457 693444012389 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 693444012390 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 693444012391 DNA-binding site [nucleotide binding]; DNA binding site 693444012392 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 693444012393 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693444012394 homodimer interface [polypeptide binding]; other site 693444012395 catalytic residue [active] 693444012396 YebF-like protein; Region: YebF; cl10126 693444012397 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 693444012398 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 693444012399 active site 693444012400 HIGH motif; other site 693444012401 dimer interface [polypeptide binding]; other site 693444012402 KMSKS motif; other site 693444012403 Predicted restriction endonuclease [Defense mechanisms]; Region: COG3440 693444012404 HNH endonuclease; Region: HNH_2; pfam13391 693444012405 Protein of unknown function (DUF1219); Region: DUF1219; pfam06755 693444012406 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 693444012407 Transposase; Region: HTH_Tnp_1; cl17663 693444012408 HTH-like domain; Region: HTH_21; pfam13276 693444012409 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 693444012410 Integrase core domain; Region: rve; pfam00665 693444012411 Integrase core domain; Region: rve_3; pfam13683 693444012412 DEAD-like helicases superfamily; Region: DEXDc; smart00487 693444012413 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 693444012414 ATP binding site [chemical binding]; other site 693444012415 putative Mg++ binding site [ion binding]; other site 693444012416 Type III restriction/modification enzyme methylation subunit; Region: TypeIII_RM_meth; pfam12564 693444012417 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 693444012418 DNA methylase; Region: N6_N4_Mtase; pfam01555 693444012419 DNA methylase; Region: N6_N4_Mtase; pfam01555 693444012420 integrase; Provisional; Region: PRK09692 693444012421 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 693444012422 active site 693444012423 Int/Topo IB signature motif; other site 693444012424 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 693444012425 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 693444012426 putative NAD(P) binding site [chemical binding]; other site 693444012427 putative substrate binding site [chemical binding]; other site 693444012428 catalytic Zn binding site [ion binding]; other site 693444012429 structural Zn binding site [ion binding]; other site 693444012430 dimer interface [polypeptide binding]; other site 693444012431 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 693444012432 lipopolysaccharide ABC transporter permease; Provisional; Region: PRK15071 693444012433 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 693444012434 lipopolysaccharide ABC transporter permease LptF; Provisional; Region: PRK15120 693444012435 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 693444012436 multifunctional aminopeptidase A; Provisional; Region: PRK00913 693444012437 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 693444012438 interface (dimer of trimers) [polypeptide binding]; other site 693444012439 Substrate-binding/catalytic site; other site 693444012440 Zn-binding sites [ion binding]; other site 693444012441 DNA polymerase III subunit chi; Validated; Region: PRK05728 693444012442 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 693444012443 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 693444012444 HIGH motif; other site 693444012445 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 693444012446 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 693444012447 active site 693444012448 KMSKS motif; other site 693444012449 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 693444012450 tRNA binding surface [nucleotide binding]; other site 693444012451 anticodon binding site; other site 693444012452 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 693444012453 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 693444012454 Coenzyme A binding pocket [chemical binding]; other site 693444012455 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 693444012456 MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910 693444012457 active site 693444012458 dinuclear metal binding site [ion binding]; other site 693444012459 dimerization interface [polypeptide binding]; other site 693444012460 RNase E inhibitor protein; Provisional; Region: PRK11191 693444012461 ornithine carbamoyltransferase subunit I; Provisional; Region: PRK03515 693444012462 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 693444012463 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 693444012464 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 693444012465 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 693444012466 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 693444012467 putative fimbrial outer membrane usher protein StfC; Provisional; Region: PRK15284 693444012468 PapC N-terminal domain; Region: PapC_N; pfam13954 693444012469 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 693444012470 PapC C-terminal domain; Region: PapC_C; pfam13953 693444012471 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 693444012472 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 693444012473 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 693444012474 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 693444012475 Fimbrial protein; Region: Fimbrial; cl01416 693444012476 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 693444012477 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 693444012478 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 693444012479 catalytic residues [active] 693444012480 hinge region; other site 693444012481 alpha helical domain; other site 693444012482 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 693444012483 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 693444012484 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 693444012485 putative active site [active] 693444012486 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 693444012487 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 693444012488 Walker A/P-loop; other site 693444012489 ATP binding site [chemical binding]; other site 693444012490 Q-loop/lid; other site 693444012491 ABC transporter signature motif; other site 693444012492 Walker B; other site 693444012493 D-loop; other site 693444012494 H-loop/switch region; other site 693444012495 macrolide transporter subunit MacA; Provisional; Region: PRK11578 693444012496 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 693444012497 HlyD family secretion protein; Region: HlyD_3; pfam13437 693444012498 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 693444012499 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 693444012500 Walker A/P-loop; other site 693444012501 ATP binding site [chemical binding]; other site 693444012502 Q-loop/lid; other site 693444012503 ABC transporter signature motif; other site 693444012504 Walker B; other site 693444012505 D-loop; other site 693444012506 H-loop/switch region; other site 693444012507 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 693444012508 FtsX-like permease family; Region: FtsX; pfam02687 693444012509 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 693444012510 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 693444012511 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 693444012512 dimer interface [polypeptide binding]; other site 693444012513 active site 693444012514 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 693444012515 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 693444012516 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 693444012517 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 693444012518 NAD(P) binding site [chemical binding]; other site 693444012519 active site 693444012520 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 693444012521 Zn2+ binding site [ion binding]; other site 693444012522 Mg2+ binding site [ion binding]; other site 693444012523 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 693444012524 Zn2+ binding site [ion binding]; other site 693444012525 Mg2+ binding site [ion binding]; other site 693444012526 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 693444012527 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 693444012528 DNA binding site [nucleotide binding] 693444012529 Aspartate carbamoyltransferase, catalytic chain [Nucleotide transport and metabolism]; Region: PyrB; COG0540 693444012530 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 693444012531 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 693444012532 aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893 693444012533 Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948 693444012534 Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748 693444012535 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 693444012536 homotrimer interaction site [polypeptide binding]; other site 693444012537 putative active site [active] 693444012538 magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517 693444012539 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 693444012540 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 693444012541 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 693444012542 Soluble P-type ATPase [General function prediction only]; Region: COG4087 693444012543 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 693444012544 trehalose repressor; Provisional; Region: treR; PRK09492 693444012545 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 693444012546 DNA binding site [nucleotide binding] 693444012547 domain linker motif; other site 693444012548 Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542 693444012549 dimerization interface [polypeptide binding]; other site 693444012550 ligand binding site [chemical binding]; other site 693444012551 PTS system trehalose(maltose)-specific transporter subunits IIBC; Provisional; Region: PRK11007 693444012552 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 693444012553 active site turn [active] 693444012554 phosphorylation site [posttranslational modification] 693444012555 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 693444012556 trehalose-6-phosphate hydrolase; Provisional; Region: PRK10933 693444012557 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 693444012558 Ca binding site [ion binding]; other site 693444012559 active site 693444012560 catalytic site [active] 693444012561 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 693444012562 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 693444012563 ATP cone domain; Region: ATP-cone; pfam03477 693444012564 Class III ribonucleotide reductase; Region: RNR_III; cd01675 693444012565 effector binding site; other site 693444012566 active site 693444012567 Zn binding site [ion binding]; other site 693444012568 glycine loop; other site 693444012569 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491 693444012570 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 693444012571 FeS/SAM binding site; other site 693444012572 SnoaL-like domain; Region: SnoaL_4; pfam13577 693444012573 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 693444012574 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693444012575 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 693444012576 dimerization interface [polypeptide binding]; other site 693444012577 substrate binding pocket [chemical binding]; other site 693444012578 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 693444012579 HTH domain; Region: HTH_11; pfam08279 693444012580 Mga helix-turn-helix domain; Region: Mga; pfam05043 693444012581 PRD domain; Region: PRD; pfam00874 693444012582 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 693444012583 active site 693444012584 P-loop; other site 693444012585 phosphorylation site [posttranslational modification] 693444012586 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 693444012587 active site 693444012588 phosphorylation site [posttranslational modification] 693444012589 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 693444012590 conserved hypothetical protein EF_0839/AHA_3917; Region: EF_0839; TIGR03581 693444012591 uncharacterized pyridoxal phosphate-dependent enzyme; Region: selA_rel; TIGR01437 693444012592 dihydroorotase; Provisional; Region: PRK09237 693444012593 Metallo-dependent hydrolases, subgroup B is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_B; cd01307 693444012594 active site 693444012595 conserved hypothetical protein EF_0833/AHA_3914; Region: EF_0833; TIGR03579 693444012596 conserved hypothetical protein EF_0832/AHA_3913; Region: EF_0832; TIGR03580 693444012597 conserved hypothetical protein EF_0831/AHA_3912; Region: EF_0831; TIGR03578 693444012598 Glycine-rich SFCGS; Region: Gly_rich_SFCGS; pfam14272 693444012599 PRD domain protein EF_0829/AHA_3910; Region: EF_0829; TIGR03582 693444012600 Protein of unknown function (DUF2726); Region: DUF2726; pfam10881 693444012601 Cytochrome b562; Region: Cytochrom_B562; cl01546 693444012602 peptidase PmbA; Provisional; Region: PRK11040 693444012603 hypothetical protein; Provisional; Region: PRK05255 693444012604 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 693444012605 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 693444012606 Coenzyme A binding pocket [chemical binding]; other site 693444012607 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 693444012608 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 693444012609 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 693444012610 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 693444012611 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 693444012612 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 693444012613 AMP binding site [chemical binding]; other site 693444012614 metal binding site [ion binding]; metal-binding site 693444012615 active site 693444012616 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 693444012617 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 693444012618 TM-ABC transporter signature motif; other site 693444012619 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 693444012620 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 693444012621 TM-ABC transporter signature motif; other site 693444012622 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 693444012623 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 693444012624 Walker A/P-loop; other site 693444012625 ATP binding site [chemical binding]; other site 693444012626 Q-loop/lid; other site 693444012627 ABC transporter signature motif; other site 693444012628 Walker B; other site 693444012629 D-loop; other site 693444012630 H-loop/switch region; other site 693444012631 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 693444012632 Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309 693444012633 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 693444012634 putative ligand binding site [chemical binding]; other site 693444012635 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 693444012636 dimer interface [polypeptide binding]; other site 693444012637 substrate binding site [chemical binding]; other site 693444012638 metal binding sites [ion binding]; metal-binding site 693444012639 PemK-like protein; Region: PemK; cl00995 693444012640 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 693444012641 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 693444012642 putative active site pocket [active] 693444012643 dimerization interface [polypeptide binding]; other site 693444012644 putative catalytic residue [active] 693444012645 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 693444012646 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 693444012647 Family of unknown function (DUF490); Region: DUF490; pfam04357 693444012648 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 693444012649 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 693444012650 Surface antigen; Region: Bac_surface_Ag; pfam01103 693444012651 methionine sulfoxide reductase A; Provisional; Region: PRK00058 693444012652 Transcriptional regulators [Transcription]; Region: PurR; COG1609 693444012653 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 693444012654 DNA binding site [nucleotide binding] 693444012655 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 693444012656 ligand binding site [chemical binding]; other site 693444012657 dimerization interface [polypeptide binding]; other site 693444012658 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 693444012659 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 693444012660 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 693444012661 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 693444012662 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 693444012663 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 693444012664 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 693444012665 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 693444012666 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 693444012667 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 693444012668 Domain of unknown function DUF21; Region: DUF21; pfam01595 693444012669 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 693444012670 Transporter associated domain; Region: CorC_HlyC; smart01091 693444012671 Protein of unknown function (DUF1107); Region: DUF1107; pfam06526 693444012672 Predicted transcriptional regulator [General function prediction only]; Region: COG3054 693444012673 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 693444012674 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 693444012675 active site 693444012676 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420 693444012677 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 693444012678 active site 693444012679 metal binding site [ion binding]; metal-binding site 693444012680 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 693444012681 Predicted transcriptional regulators [Transcription]; Region: COG1733 693444012682 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 693444012683 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 693444012684 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 693444012685 NADP binding site [chemical binding]; other site 693444012686 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 693444012687 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 693444012688 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 693444012689 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 693444012690 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 693444012691 EamA-like transporter family; Region: EamA; pfam00892 693444012692 iron-sulfur cluster repair di-iron protein; Provisional; Region: PRK10992 693444012693 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 693444012694 Hemerythrin-like domain; Region: Hr-like; cd12108 693444012695 Fe binding site [ion binding]; other site 693444012696 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 693444012697 peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK11570 693444012698 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 693444012699 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 693444012700 Cell envelope opacity-associated protein A [Cell envelope biogenesis, outer membrane]; Region: OapA; COG3061 693444012701 Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225 693444012702 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 693444012703 EamA-like transporter family; Region: EamA; pfam00892 693444012704 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 693444012705 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 693444012706 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 693444012707 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 693444012708 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 693444012709 dimer interface [polypeptide binding]; other site 693444012710 ssDNA binding site [nucleotide binding]; other site 693444012711 tetramer (dimer of dimers) interface [polypeptide binding]; other site 693444012712 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 693444012713 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 693444012714 Protein of unknown function (DUF1440); Region: DUF1440; pfam07274 693444012715 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 693444012716 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 693444012717 intersubunit interface [polypeptide binding]; other site 693444012718 active site 693444012719 Zn2+ binding site [ion binding]; other site 693444012720 L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13209 693444012721 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 693444012722 AP (apurinic/apyrimidinic) site pocket; other site 693444012723 DNA interaction; other site 693444012724 Metal-binding active site; metal-binding site 693444012725 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 693444012726 active site 693444012727 dimer interface [polypeptide binding]; other site 693444012728 magnesium binding site [ion binding]; other site 693444012729 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 693444012730 active site 693444012731 phosphorylation site [posttranslational modification] 693444012732 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 693444012733 active site 693444012734 P-loop; other site 693444012735 phosphorylation site [posttranslational modification] 693444012736 Uncharacterized protein conserved in bacteria [Function unknown]; Region: SgaT; COG3037 693444012737 PTS system ascorbate-specific transporter subunits IICB; Provisional; Region: PRK09548 693444012738 putative L-ascorbate 6-phosphate lactonase; Provisional; Region: PRK11709 693444012739 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 693444012740 transcriptional repressor UlaR; Provisional; Region: PRK13509 693444012741 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 693444012742 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 693444012743 esterase; Provisional; Region: PRK10566 693444012744 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 693444012745 putative biofilm stress and motility protein A; Provisional; Region: PRK14864 693444012746 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 693444012747 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 693444012748 Proteins involved in DNA damage response, similar to the AidB gene product; Region: AidB; cd01154 693444012749 FAD binding site [chemical binding]; other site 693444012750 substrate binding site [chemical binding]; other site 693444012751 catalytic residues [active] 693444012752 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 693444012753 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 693444012754 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 693444012755 exoribonuclease R; Provisional; Region: PRK11642 693444012756 Ribonuclease R winged-helix domain; Region: HTH_12; pfam08461 693444012757 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 693444012758 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 693444012759 RNB domain; Region: RNB; pfam00773 693444012760 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 693444012761 RNA binding site [nucleotide binding]; other site 693444012762 Predicted transcriptional regulator [Transcription]; Region: COG1959 693444012763 transcriptional repressor NsrR; Provisional; Region: PRK11014 693444012764 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 693444012765 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 693444012766 GDP-binding site [chemical binding]; other site 693444012767 ACT binding site; other site 693444012768 IMP binding site; other site 693444012769 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3242 693444012770 FtsH protease regulator HflC; Provisional; Region: PRK11029 693444012771 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 693444012772 FtsH protease regulator HflK; Provisional; Region: PRK10930 693444012773 Bacterial membrane protein N terminal; Region: HflK_N; pfam12221 693444012774 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 693444012775 GTPase HflX; Provisional; Region: PRK11058 693444012776 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 693444012777 HflX GTPase family; Region: HflX; cd01878 693444012778 G1 box; other site 693444012779 GTP/Mg2+ binding site [chemical binding]; other site 693444012780 Switch I region; other site 693444012781 G2 box; other site 693444012782 G3 box; other site 693444012783 Switch II region; other site 693444012784 G4 box; other site 693444012785 G5 box; other site 693444012786 bacterial Hfq-like; Region: Hfq; cd01716 693444012787 hexamer interface [polypeptide binding]; other site 693444012788 Sm1 motif; other site 693444012789 RNA binding site [nucleotide binding]; other site 693444012790 Sm2 motif; other site 693444012791 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 693444012792 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 693444012793 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 693444012794 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693444012795 ATP binding site [chemical binding]; other site 693444012796 Mg2+ binding site [ion binding]; other site 693444012797 G-X-G motif; other site 693444012798 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 693444012799 ATP binding site [chemical binding]; other site 693444012800 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 693444012801 N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431 693444012802 AMIN domain; Region: AMIN; pfam11741 693444012803 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 693444012804 active site 693444012805 metal binding site [ion binding]; metal-binding site 693444012806 ADP-binding protein; Provisional; Region: PRK10646 693444012807 putative carbohydrate kinase; Provisional; Region: PRK10565 693444012808 Uncharacterized conserved protein [Function unknown]; Region: COG0062 693444012809 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 693444012810 putative substrate binding site [chemical binding]; other site 693444012811 putative ATP binding site [chemical binding]; other site 693444012812 epoxyqueuosine reductase; Region: TIGR00276 693444012813 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 693444012814 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 693444012815 catalytic site [active] 693444012816 putative active site [active] 693444012817 putative substrate binding site [chemical binding]; other site 693444012818 dimer interface [polypeptide binding]; other site 693444012819 GTPase RsgA; Reviewed; Region: PRK12288 693444012820 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 693444012821 RNA binding site [nucleotide binding]; other site 693444012822 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 693444012823 GTPase/Zn-binding domain interface [polypeptide binding]; other site 693444012824 GTP/Mg2+ binding site [chemical binding]; other site 693444012825 G4 box; other site 693444012826 G5 box; other site 693444012827 G1 box; other site 693444012828 Switch I region; other site 693444012829 G2 box; other site 693444012830 G3 box; other site 693444012831 Switch II region; other site 693444012832 phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044 693444012833 putative mechanosensitive channel protein; Provisional; Region: PRK10929 693444012834 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 693444012835 Mechanosensitive ion channel; Region: MS_channel; pfam00924 693444012836 inner membrane transporter YjeM; Provisional; Region: PRK15238 693444012837 poxB regulator PoxA; Provisional; Region: PRK09350 693444012838 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 693444012839 motif 1; other site 693444012840 dimer interface [polypeptide binding]; other site 693444012841 active site 693444012842 motif 2; other site 693444012843 motif 3; other site 693444012844 fumarate reductase flavoprotein subunit; Validated; Region: PRK09231 693444012845 L-aspartate oxidase; Provisional; Region: PRK06175 693444012846 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 693444012847 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12385 693444012848 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 693444012849 catalytic loop [active] 693444012850 iron binding site [ion binding]; other site 693444012851 Quinol:fumarate reductase (QFR) Type D subfamily, 15kD hydrophobic subunit C; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitC; cd00546 693444012852 D-subunit interface [polypeptide binding]; other site 693444012853 Iron-sulfur protein interface; other site 693444012854 proximal quinone binding site [chemical binding]; other site 693444012855 Quinol:fumarate reductase (QFR) Type D subfamily, 13kD hydrophobic subunit D; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitD; cd00547 693444012856 Iron-sulfur protein interface; other site 693444012857 proximal quinone binding site [chemical binding]; other site 693444012858 C-subunit interface; other site 693444012859 distal quinone binding site; other site 693444012860 beta-lactamase/D-alanine carboxypeptidase; Provisional; Region: ampC; PRK11289 693444012861 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 693444012862 outer membrane lipoprotein Blc; Provisional; Region: PRK10477 693444012863 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 693444012864 multidrug efflux system protein; Provisional; Region: PRK11431 693444012865 mini-ykkC RNA motif; D782_4111; IMG reference gene:2507518807 693444012866 entericidin B membrane lipoprotein; Provisional; Region: PRK10081 693444012867 entericidin A; Provisional; Region: PRK09810 693444012868 elongation factor P; Validated; Region: PRK00529 693444012869 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 693444012870 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 693444012871 RNA binding site [nucleotide binding]; other site 693444012872 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 693444012873 RNA binding site [nucleotide binding]; other site 693444012874 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 693444012875 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 693444012876 FeS/SAM binding site; other site 693444012877 Domain of unknown function (DUF4156); Region: DUF4156; pfam13698 693444012878 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 693444012879 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 693444012880 ring oligomerisation interface [polypeptide binding]; other site 693444012881 ATP/Mg binding site [chemical binding]; other site 693444012882 stacking interactions; other site 693444012883 hinge regions; other site 693444012884 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 693444012885 oligomerisation interface [polypeptide binding]; other site 693444012886 mobile loop; other site 693444012887 roof hairpin; other site 693444012888 histidine-histamine antiporter; Region: his_histam_anti; TIGR04298 693444012889 Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030 693444012890 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 693444012891 Aspartase; Region: Aspartase; cd01357 693444012892 active sites [active] 693444012893 tetramer interface [polypeptide binding]; other site 693444012894 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 693444012895 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 693444012896 divalent-cation tolerance protein CutA; Provisional; Region: PRK10645 693444012897 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 693444012898 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 693444012899 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 693444012900 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 693444012901 DsbD alpha interface [polypeptide binding]; other site 693444012902 catalytic residues [active] 693444012903 putative transcriptional regulator; Provisional; Region: PRK11640 693444012904 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 693444012905 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 693444012906 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 693444012907 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 693444012908 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 693444012909 metal ion-dependent adhesion site (MIDAS); other site 693444012910 type I secretion C-terminal target domain (VC_A0849 subclass); Region: T1SS_VCA0849; TIGR03661 693444012911 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 693444012912 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39_likeD; cd02421 693444012913 type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375 693444012914 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 693444012915 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693444012916 Walker A/P-loop; other site 693444012917 ATP binding site [chemical binding]; other site 693444012918 Q-loop/lid; other site 693444012919 ABC transporter signature motif; other site 693444012920 Walker B; other site 693444012921 D-loop; other site 693444012922 H-loop/switch region; other site 693444012923 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 693444012924 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 693444012925 HlyD family secretion protein; Region: HlyD_3; pfam13437 693444012926 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 693444012927 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 693444012928 Predicted transglutaminase-like cysteine proteinase [General function prediction only]; Region: COG3672 693444012929 HAMP domain; Region: HAMP; pfam00672 693444012930 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693444012931 metal binding site [ion binding]; metal-binding site 693444012932 active site 693444012933 I-site; other site 693444012934 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 693444012935 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 693444012936 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39_likeD; cd02421 693444012937 type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375 693444012938 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 693444012939 ATP-binding cassette domain of bacteriocin exporters, subfamily C; Region: ABCC_bacteriocin_exporters; cd03245 693444012940 Walker A/P-loop; other site 693444012941 ATP binding site [chemical binding]; other site 693444012942 Q-loop/lid; other site 693444012943 ABC transporter signature motif; other site 693444012944 Walker B; other site 693444012945 D-loop; other site 693444012946 H-loop/switch region; other site 693444012947 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 693444012948 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 693444012949 HlyD family secretion protein; Region: HlyD_3; pfam13437 693444012950 acyl-CoA synthetase; Validated; Region: PRK09192 693444012951 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 693444012952 acyl-activating enzyme (AAE) consensus motif; other site 693444012953 active site 693444012954 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271 693444012955 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 693444012956 putative NAD(P) binding site [chemical binding]; other site 693444012957 active site 693444012958 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 693444012959 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 693444012960 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 693444012961 catalytic residue [active] 693444012962 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 693444012963 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 693444012964 Predicted permeases [General function prediction only]; Region: COG0795 693444012965 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 693444012966 Bacterial protein of unknown function (YtfJ_HI0045); Region: YtfJ_HI0045; pfam09695 693444012967 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 693444012968 Polysaccharide biosynthesis protein; Region: Polysacc_synt_3; pfam13440 693444012969 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 693444012970 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 693444012971 Thymidylate kinase; Region: Thymidylate_kin; pfam02223 693444012972 active site 693444012973 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 693444012974 active site 693444012975 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 693444012976 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 693444012977 TMP-binding site; other site 693444012978 ATP-binding site [chemical binding]; other site 693444012979 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 693444012980 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 693444012981 proline/glycine betaine transporter; Provisional; Region: PRK10642 693444012982 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693444012983 putative substrate translocation pore; other site 693444012984 Osmosensory transporter coiled coil; Region: Osmo_CC; pfam08946 693444012985 2-keto-3-deoxygluconate permease; Region: KdgT; cl14653 693444012986 hypothetical protein; Provisional; Region: PRK10220 693444012987 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 693444012988 PhnA protein; Region: PhnA; pfam03831 693444012989 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 693444012990 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 693444012991 dimer interface [polypeptide binding]; other site 693444012992 phosphonate/organophosphate ester transporter subunit; Provisional; Region: PRK09984 693444012993 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 693444012994 Walker A/P-loop; other site 693444012995 ATP binding site [chemical binding]; other site 693444012996 Q-loop/lid; other site 693444012997 ABC transporter signature motif; other site 693444012998 Walker B; other site 693444012999 D-loop; other site 693444013000 H-loop/switch region; other site 693444013001 phosphonate ABC transporter, periplasmic phosphonate binding protein; Region: PhnD; TIGR03431 693444013002 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 693444013003 substrate binding pocket [chemical binding]; other site 693444013004 membrane-bound complex binding site; other site 693444013005 hinge residues; other site 693444013006 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 693444013007 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693444013008 dimer interface [polypeptide binding]; other site 693444013009 conserved gate region; other site 693444013010 putative PBP binding loops; other site 693444013011 ABC-ATPase subunit interface; other site 693444013012 phosphonate metabolism transcriptional regulator PhnF; Provisional; Region: PRK10079 693444013013 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 693444013014 DNA-binding site [nucleotide binding]; DNA binding site 693444013015 UTRA domain; Region: UTRA; pfam07702 693444013016 Phosphonate metabolism protein PhnG; Region: PhnG; pfam06754 693444013017 Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnH; COG3625 693444013018 Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnI; COG3626 693444013019 Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnJ; COG3627 693444013020 phosphonate C-P lyase system protein PhnK; Provisional; Region: phnK; PRK11701 693444013021 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 693444013022 Walker A/P-loop; other site 693444013023 ATP binding site [chemical binding]; other site 693444013024 Q-loop/lid; other site 693444013025 ABC transporter signature motif; other site 693444013026 Walker B; other site 693444013027 D-loop; other site 693444013028 H-loop/switch region; other site 693444013029 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 693444013030 ABC-type phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PhnL; COG4778 693444013031 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 693444013032 Walker A/P-loop; other site 693444013033 ATP binding site [chemical binding]; other site 693444013034 Q-loop/lid; other site 693444013035 ABC transporter signature motif; other site 693444013036 Walker B; other site 693444013037 D-loop; other site 693444013038 H-loop/switch region; other site 693444013039 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 693444013040 Metal-dependent hydrolase involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: COG3454 693444013041 PhnM is believed to be a subunit of the membrane associated C-P lyase complex. C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage...; Region: PhnM; cd01306 693444013042 active site 693444013043 ribose 1,5-bisphosphokinase; Provisional; Region: PRK10078 693444013044 AAA domain; Region: AAA_18; pfam13238 693444013045 active site 693444013046 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 693444013047 Coenzyme A binding pocket [chemical binding]; other site 693444013048 carbon-phosphorus lyase complex accessory protein; Provisional; Region: phnP; PRK11244 693444013049 putative hydrolase; Provisional; Region: PRK02113 693444013050 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 693444013051 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 693444013052 multidrug resistance protein MdtN; Provisional; Region: PRK10476 693444013053 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 693444013054 HlyD family secretion protein; Region: HlyD_3; pfam13437 693444013055 multidrug efflux system protein MdtO; Provisional; Region: PRK11427 693444013056 putative outer membrane efflux protein MdtP; Provisional; Region: PRK09915 693444013057 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 693444013058 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 693444013059 molybdopterin cofactor binding site; other site 693444013060 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790 693444013061 molybdopterin cofactor binding site; other site 693444013062 glutamate/aspartate:proton symporter; Provisional; Region: gltP; PRK11283 693444013063 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 693444013064 acetyl-CoA synthetase; Provisional; Region: PRK00174 693444013065 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 693444013066 active site 693444013067 CoA binding site [chemical binding]; other site 693444013068 acyl-activating enzyme (AAE) consensus motif; other site 693444013069 AMP binding site [chemical binding]; other site 693444013070 acetate binding site [chemical binding]; other site 693444013071 Predicted membrane protein [Function unknown]; Region: COG3162 693444013072 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 693444013073 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 693444013074 Na binding site [ion binding]; other site 693444013075 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 693444013076 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 693444013077 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 693444013078 Hok/gef family; Region: HOK_GEF; pfam01848 693444013079 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 693444013080 Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380 693444013081 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693444013082 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693444013083 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 693444013084 putative dimerization interface [polypeptide binding]; other site 693444013085 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 693444013086 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 693444013087 Transcriptional regulators [Transcription]; Region: PurR; COG1609 693444013088 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 693444013089 DNA binding site [nucleotide binding] 693444013090 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 693444013091 putative dimerization interface [polypeptide binding]; other site 693444013092 putative ligand binding site [chemical binding]; other site 693444013093 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 693444013094 active site 693444013095 phosphorylation site [posttranslational modification] 693444013096 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 693444013097 active site 693444013098 P-loop; other site 693444013099 phosphorylation site [posttranslational modification] 693444013100 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 693444013101 transketolase; Reviewed; Region: PRK05899 693444013102 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 693444013103 TPP-binding site [chemical binding]; other site 693444013104 dimer interface [polypeptide binding]; other site 693444013105 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 693444013106 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 693444013107 PYR/PP interface [polypeptide binding]; other site 693444013108 dimer interface [polypeptide binding]; other site 693444013109 TPP binding site [chemical binding]; other site 693444013110 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 693444013111 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 693444013112 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 693444013113 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 693444013114 putative C-terminal domain interface [polypeptide binding]; other site 693444013115 putative GSH binding site (G-site) [chemical binding]; other site 693444013116 putative dimer interface [polypeptide binding]; other site 693444013117 C-terminal, alpha helical domain of GTT1-like Glutathione S-transferases; Region: GST_C_GTT1_like; cd03189 693444013118 putative N-terminal domain interface [polypeptide binding]; other site 693444013119 putative dimer interface [polypeptide binding]; other site 693444013120 putative substrate binding pocket (H-site) [chemical binding]; other site 693444013121 redox-sensitivie transcriptional activator SoxR; Provisional; Region: PRK15002 693444013122 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 693444013123 DNA binding residues [nucleotide binding] 693444013124 dimer interface [polypeptide binding]; other site 693444013125 [2Fe-2S] cluster binding site [ion binding]; other site 693444013126 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 693444013127 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 693444013128 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 693444013129 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 693444013130 dimer interface [polypeptide binding]; other site 693444013131 ssDNA binding site [nucleotide binding]; other site 693444013132 tetramer (dimer of dimers) interface [polypeptide binding]; other site 693444013133 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 693444013134 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 693444013135 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 693444013136 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 693444013137 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 693444013138 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 693444013139 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 693444013140 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 693444013141 active site 693444013142 motif I; other site 693444013143 motif II; other site 693444013144 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 693444013145 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 693444013146 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 693444013147 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693444013148 homodimer interface [polypeptide binding]; other site 693444013149 catalytic residue [active] 693444013150 alanine racemase; Reviewed; Region: alr; PRK00053 693444013151 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 693444013152 active site 693444013153 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 693444013154 substrate binding site [chemical binding]; other site 693444013155 catalytic residues [active] 693444013156 dimer interface [polypeptide binding]; other site 693444013157 replicative DNA helicase; Provisional; Region: PRK08006 693444013158 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 693444013159 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 693444013160 Walker A motif; other site 693444013161 ATP binding site [chemical binding]; other site 693444013162 Walker B motif; other site 693444013163 DNA binding loops [nucleotide binding] 693444013164 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 693444013165 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 693444013166 NADP binding site [chemical binding]; other site 693444013167 dimer interface [polypeptide binding]; other site 693444013168 phage shock protein G; Reviewed; Region: pspG; PRK09459 693444013169 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 693444013170 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 693444013171 FMN binding site [chemical binding]; other site 693444013172 active site 693444013173 catalytic residues [active] 693444013174 substrate binding site [chemical binding]; other site 693444013175 F plasmid transfer operon, TraF, protein; Region: TraF_2; pfam13729 693444013176 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 693444013177 metal binding site 2 [ion binding]; metal-binding site 693444013178 putative DNA binding helix; other site 693444013179 metal binding site 1 [ion binding]; metal-binding site 693444013180 dimer interface [polypeptide binding]; other site 693444013181 structural Zn2+ binding site [ion binding]; other site 693444013182 hypothetical protein; Provisional; Region: PRK10428 693444013183 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 693444013184 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 693444013185 LexA repressor; Validated; Region: PRK00215 693444013186 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 693444013187 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 693444013188 Catalytic site [active] 693444013189 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 693444013190 glycerol-3-phosphate O-acyltransferase; Region: plsB; TIGR03703 693444013191 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 693444013192 putative acyl-acceptor binding pocket; other site 693444013193 4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848 693444013194 UbiA prenyltransferase family; Region: UbiA; pfam01040 693444013195 chorismate pyruvate lyase; Provisional; Region: ubiC; PRK11655 693444013196 maltose regulon periplasmic protein; Provisional; Region: PRK10564 693444013197 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 693444013198 trimer interface; other site 693444013199 sugar binding site [chemical binding]; other site 693444013200 maltose/maltodextrin transporter ATP-binding protein; Provisional; Region: PRK11000 693444013201 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 693444013202 Walker A/P-loop; other site 693444013203 ATP binding site [chemical binding]; other site 693444013204 Q-loop/lid; other site 693444013205 ABC transporter signature motif; other site 693444013206 Walker B; other site 693444013207 D-loop; other site 693444013208 H-loop/switch region; other site 693444013209 TOBE domain; Region: TOBE_2; pfam08402 693444013210 maltose ABC transporter periplasmic protein; Reviewed; Region: malE; PRK09474 693444013211 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 693444013212 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 693444013213 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693444013214 dimer interface [polypeptide binding]; other site 693444013215 conserved gate region; other site 693444013216 putative PBP binding loops; other site 693444013217 ABC-ATPase subunit interface; other site 693444013218 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 693444013219 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693444013220 dimer interface [polypeptide binding]; other site 693444013221 conserved gate region; other site 693444013222 putative PBP binding loops; other site 693444013223 ABC-ATPase subunit interface; other site 693444013224 phosphate-starvation-inducible protein PsiE; Provisional; Region: PRK02833 693444013225 Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082 693444013226 Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251 693444013227 Protein of unknown function (DUF2886); Region: DUF2886; pfam11102 693444013228 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 693444013229 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 693444013230 active site 693444013231 dimer interface [polypeptide binding]; other site 693444013232 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 693444013233 dimer interface [polypeptide binding]; other site 693444013234 active site 693444013235 aspartate kinase III; Validated; Region: PRK09084 693444013236 AAK_AKiii-LysC-EC: Amino Acid Kinase Superfamily (AAK), AKiii-LysC-EC: this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKIII. AKIII is a monofunctional class enzyme (LysC) found in some...; Region: AAK_AKiii-LysC-EC; cd04258 693444013237 nucleotide binding site [chemical binding]; other site 693444013238 putative catalytic residues [active] 693444013239 aspartate binding site [chemical binding]; other site 693444013240 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_1; cd04932 693444013241 lysine allosteric regulatory site; other site 693444013242 dimer interface [polypeptide binding]; other site 693444013243 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_2; cd04917 693444013244 dimer interface [polypeptide binding]; other site 693444013245 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 693444013246 Sodium Bile acid symporter family; Region: SBF; cl17470 693444013247 Uncharacterized conserved small protein [Function unknown]; Region: COG5606 693444013248 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 693444013249 hypothetical protein; Provisional; Region: PRK10515 693444013250 23S rRNA pseudouridine synthase F; Provisional; Region: PRK10475 693444013251 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 693444013252 RNA binding surface [nucleotide binding]; other site 693444013253 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 693444013254 probable active site [active] 693444013255 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 693444013256 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 693444013257 putative DNA binding site [nucleotide binding]; other site 693444013258 putative Zn2+ binding site [ion binding]; other site 693444013259 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 693444013260 sorbitol-6-phosphate 2-dehydrogenase; Provisional; Region: PRK06171 693444013261 classical (c) SDRs; Region: SDR_c; cd05233 693444013262 NAD(P) binding site [chemical binding]; other site 693444013263 active site 693444013264 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 693444013265 active pocket/dimerization site; other site 693444013266 active site 693444013267 phosphorylation site [posttranslational modification] 693444013268 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 693444013269 active site 693444013270 phosphorylation site [posttranslational modification] 693444013271 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 693444013272 PTS system, mannose/fructose/sorbose family, IID component; Region: EIID-AGA; TIGR00828 693444013273 L-sorbose-1-phosphate reductase; Region: sorbose_phosphate_red; cd08238 693444013274 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 693444013275 putative NAD(P) binding site [chemical binding]; other site 693444013276 catalytic Zn binding site [ion binding]; other site 693444013277 shikimate 5-dehydrogenase; Reviewed; Region: PRK12550 693444013278 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 693444013279 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 693444013280 shikimate binding site; other site 693444013281 NAD(P) binding site [chemical binding]; other site 693444013282 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 693444013283 active site pocket [active] 693444013284 oxyanion hole [active] 693444013285 catalytic triad [active] 693444013286 active site nucleophile [active] 693444013287 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 693444013288 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 693444013289 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 693444013290 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 693444013291 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 693444013292 substrate binding pocket [chemical binding]; other site 693444013293 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 693444013294 B12 binding site [chemical binding]; other site 693444013295 cobalt ligand [ion binding]; other site 693444013296 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 693444013297 transcriptional repressor IclR; Provisional; Region: PRK11569 693444013298 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 693444013299 Bacterial transcriptional regulator; Region: IclR; pfam01614 693444013300 bifunctional isocitrate dehydrogenase kinase/phosphatase protein; Validated; Region: aceK; PRK02946 693444013301 Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579 693444013302 isocitrate lyase; Provisional; Region: PRK15063 693444013303 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 693444013304 tetramer interface [polypeptide binding]; other site 693444013305 active site 693444013306 Mg2+/Mn2+ binding site [ion binding]; other site 693444013307 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 693444013308 malate synthase A; Region: malate_syn_A; TIGR01344 693444013309 active site 693444013310 homoserine O-succinyltransferase; Provisional; Region: PRK05368 693444013311 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 693444013312 proposed active site lysine [active] 693444013313 conserved cys residue [active] 693444013314 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 693444013315 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 693444013316 Coenzyme A binding pocket [chemical binding]; other site 693444013317 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 693444013318 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 693444013319 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 693444013320 purine monophosphate binding site [chemical binding]; other site 693444013321 dimer interface [polypeptide binding]; other site 693444013322 putative catalytic residues [active] 693444013323 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 693444013324 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 693444013325 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 693444013326 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 693444013327 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 693444013328 Protein of unknown function (DUF1481); Region: DUF1481; pfam07356 693444013329 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 693444013330 IHF dimer interface [polypeptide binding]; other site 693444013331 IHF - DNA interface [nucleotide binding]; other site 693444013332 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3068 693444013333 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 693444013334 Active_site [active] 693444013335 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 693444013336 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 693444013337 substrate binding site [chemical binding]; other site 693444013338 active site 693444013339 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 693444013340 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 693444013341 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 693444013342 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 693444013343 putative NADH binding site [chemical binding]; other site 693444013344 putative active site [active] 693444013345 nudix motif; other site 693444013346 putative metal binding site [ion binding]; other site 693444013347 Regulator of sigma D [Transcription]; Region: Rsd; COG3160 693444013348 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 693444013349 ThiC-associated domain; Region: ThiC-associated; pfam13667 693444013350 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 693444013351 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 693444013352 thiamine phosphate binding site [chemical binding]; other site 693444013353 active site 693444013354 pyrophosphate binding site [ion binding]; other site 693444013355 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 693444013356 thiazole biosynthesis adenylyltransferase ThiF, E. coli subfamily; Region: adenyl_thiF; TIGR02356 693444013357 ATP binding site [chemical binding]; other site 693444013358 substrate interface [chemical binding]; other site 693444013359 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 693444013360 thiS-thiF/thiG interaction site; other site 693444013361 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 693444013362 ThiS interaction site; other site 693444013363 putative active site [active] 693444013364 tetramer interface [polypeptide binding]; other site 693444013365 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240 693444013366 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 693444013367 FeS/SAM binding site; other site 693444013368 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 693444013369 Cache domain; Region: Cache_1; pfam02743 693444013370 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 693444013371 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693444013372 metal binding site [ion binding]; metal-binding site 693444013373 active site 693444013374 I-site; other site 693444013375 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 693444013376 active site 693444013377 P-loop; other site 693444013378 phosphorylation site [posttranslational modification] 693444013379 methionine cluster; other site 693444013380 PTS system, Lactose/Cellobiose specific IIA subunit; Region: PTS_IIA; pfam02255 693444013381 active site 693444013382 phosphorylation site [posttranslational modification] 693444013383 metal binding site [ion binding]; metal-binding site 693444013384 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 693444013385 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK12489 693444013386 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 693444013387 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 693444013388 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 693444013389 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 693444013390 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 693444013391 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 693444013392 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 693444013393 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 693444013394 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 693444013395 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 693444013396 DNA binding site [nucleotide binding] 693444013397 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 693444013398 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 693444013399 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 693444013400 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 693444013401 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 693444013402 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 693444013403 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 693444013404 RPB3 interaction site [polypeptide binding]; other site 693444013405 RPB1 interaction site [polypeptide binding]; other site 693444013406 RPB11 interaction site [polypeptide binding]; other site 693444013407 RPB10 interaction site [polypeptide binding]; other site 693444013408 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 693444013409 core dimer interface [polypeptide binding]; other site 693444013410 peripheral dimer interface [polypeptide binding]; other site 693444013411 L10 interface [polypeptide binding]; other site 693444013412 L11 interface [polypeptide binding]; other site 693444013413 putative EF-Tu interaction site [polypeptide binding]; other site 693444013414 putative EF-G interaction site [polypeptide binding]; other site 693444013415 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 693444013416 23S rRNA interface [nucleotide binding]; other site 693444013417 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 693444013418 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 693444013419 mRNA/rRNA interface [nucleotide binding]; other site 693444013420 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 693444013421 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 693444013422 23S rRNA interface [nucleotide binding]; other site 693444013423 L7/L12 interface [polypeptide binding]; other site 693444013424 putative thiostrepton binding site; other site 693444013425 L25 interface [polypeptide binding]; other site 693444013426 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 693444013427 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 693444013428 putative homodimer interface [polypeptide binding]; other site 693444013429 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 693444013430 heterodimer interface [polypeptide binding]; other site 693444013431 homodimer interface [polypeptide binding]; other site 693444013432 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 693444013433 elongation factor Tu; Reviewed; Region: PRK00049 693444013434 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 693444013435 G1 box; other site 693444013436 GEF interaction site [polypeptide binding]; other site 693444013437 GTP/Mg2+ binding site [chemical binding]; other site 693444013438 Switch I region; other site 693444013439 G2 box; other site 693444013440 G3 box; other site 693444013441 Switch II region; other site 693444013442 G4 box; other site 693444013443 G5 box; other site 693444013444 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 693444013445 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 693444013446 Antibiotic Binding Site [chemical binding]; other site 693444013447 pantothenate kinase; Provisional; Region: PRK05439 693444013448 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 693444013449 ATP-binding site [chemical binding]; other site 693444013450 CoA-binding site [chemical binding]; other site 693444013451 Mg2+-binding site [ion binding]; other site 693444013452 Biotin operon repressor [Transcription]; Region: BirA; COG1654 693444013453 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 693444013454 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 693444013455 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 693444013456 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 693444013457 FAD binding domain; Region: FAD_binding_4; pfam01565 693444013458 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 693444013459 protoporphyrinogen oxidase; Provisional; Region: hemG; PRK11104 693444013460 potassium transporter; Provisional; Region: PRK10750 693444013461 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 693444013462 hypothetical protein; Provisional; Region: PRK11568 693444013463 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 693444013464 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 693444013465 proline dipeptidase; Provisional; Region: PRK13607 693444013466 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 693444013467 active site 693444013468 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 693444013469 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 693444013470 substrate binding site [chemical binding]; other site 693444013471 oxyanion hole (OAH) forming residues; other site 693444013472 trimer interface [polypeptide binding]; other site 693444013473 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 693444013474 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 693444013475 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 693444013476 3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947 693444013477 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 693444013478 dimer interface [polypeptide binding]; other site 693444013479 active site 693444013480 FMN reductase; Validated; Region: fre; PRK08051 693444013481 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 693444013482 FAD binding pocket [chemical binding]; other site 693444013483 FAD binding motif [chemical binding]; other site 693444013484 phosphate binding motif [ion binding]; other site 693444013485 beta-alpha-beta structure motif; other site 693444013486 NAD binding pocket [chemical binding]; other site 693444013487 3-octaprenyl-4-hydroxybenzoate decarboxylase; Provisional; Region: PRK10922 693444013488 transcriptional activator RfaH; Provisional; Region: rfaH; PRK09014 693444013489 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), RfaH; Region: NGN_SP_RfaH; cd09892 693444013490 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 693444013491 active site 693444013492 twin-arginine protein translocation system subunit TatC; Provisional; Region: PRK10921 693444013493 sec-independent translocase; Provisional; Region: PRK01770 693444013494 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 693444013495 putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750 693444013496 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 693444013497 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 693444013498 SCP-2 sterol transfer family; Region: SCP2; pfam02036 693444013499 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 693444013500 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693444013501 S-adenosylmethionine binding site [chemical binding]; other site 693444013502 DNA recombination protein RmuC; Provisional; Region: PRK10361 693444013503 RmuC family; Region: RmuC; pfam02646 693444013504 uridine phosphorylase; Provisional; Region: PRK11178 693444013505 uridine phosphorylase; Region: Uridine-psphlse; TIGR01718 693444013506 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 693444013507 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 693444013508 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 693444013509 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 693444013510 THF binding site; other site 693444013511 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 693444013512 substrate binding site [chemical binding]; other site 693444013513 THF binding site; other site 693444013514 zinc-binding site [ion binding]; other site 693444013515 DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421 693444013516 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693444013517 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 693444013518 putative dimerization interface [polypeptide binding]; other site 693444013519 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 693444013520 EamA-like transporter family; Region: EamA; pfam00892 693444013521 putative hydrolase; Provisional; Region: PRK10976 693444013522 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 693444013523 active site 693444013524 motif I; other site 693444013525 motif II; other site 693444013526 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 693444013527 lysophospholipase L2; Provisional; Region: PRK10749 693444013528 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 693444013529 homoserine/homoserine lactone efflux protein; Provisional; Region: rhtB; PRK10520 693444013530 putative transposase; Provisional; Region: PRK09857 693444013531 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 693444013532 threonine efflux system; Provisional; Region: PRK10229 693444013533 ATP-dependent DNA helicase RecQ; Provisional; Region: PRK11057 693444013534 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 693444013535 ATP binding site [chemical binding]; other site 693444013536 putative Mg++ binding site [ion binding]; other site 693444013537 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 693444013538 nucleotide binding region [chemical binding]; other site 693444013539 ATP-binding site [chemical binding]; other site 693444013540 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 693444013541 HRDC domain; Region: HRDC; pfam00570 693444013542 The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541 693444013543 dimerization interface [polypeptide binding]; other site 693444013544 substrate binding site [chemical binding]; other site 693444013545 active site 693444013546 calcium binding site [ion binding]; other site 693444013547 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 693444013548 CoenzymeA binding site [chemical binding]; other site 693444013549 subunit interaction site [polypeptide binding]; other site 693444013550 PHB binding site; other site 693444013551 putative chloramphenical resistance permease RarD; Provisional; Region: PRK15430 693444013552 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 693444013553 Escherichia coli Mg2+ transporter CorA_like subgroup; Region: EcCorA-like_1; cd12835 693444013554 Cl binding site [ion binding]; other site 693444013555 oligomer interface [polypeptide binding]; other site 693444013556 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 693444013557 Part of AAA domain; Region: AAA_19; pfam13245 693444013558 Family description; Region: UvrD_C_2; pfam13538 693444013559 flavin mononucleotide phosphatase; Provisional; Region: PRK10748 693444013560 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 693444013561 motif II; other site 693444013562 Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973 693444013563 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 693444013564 active site 693444013565 DNA binding site [nucleotide binding] 693444013566 Int/Topo IB signature motif; other site 693444013567 hypothetical protein; Provisional; Region: PRK10963 693444013568 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 693444013569 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 693444013570 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 693444013571 Prokaryotic lipoprotein-attachment site; Region: LPAM_2; cl02361 693444013572 Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate...; Region: Frataxin; cd00503 693444013573 putative iron binding site [ion binding]; other site 693444013574 Adenylate cyclase [Nucleotide transport and metabolism]; Region: CyaA; COG3072 693444013575 Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633 693444013576 Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295 693444013577 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 693444013578 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 693444013579 domain interfaces; other site 693444013580 active site 693444013581 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 693444013582 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 693444013583 active site 693444013584 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 693444013585 Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemX; COG2959 693444013586 putative protoheme IX biogenesis protein; Provisional; Region: PRK10747 693444013587 HemY protein N-terminus; Region: HemY_N; pfam07219 693444013588 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 693444013589 Sulfatase; Region: Sulfatase; pfam00884 693444013590 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 693444013591 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 693444013592 FeS/SAM binding site; other site 693444013593 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 693444013594 putative transport protein YifK; Provisional; Region: PRK10746 693444013595 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 693444013596 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 693444013597 putative common antigen polymerase; Provisional; Region: PRK02975 693444013598 4-alpha-L-fucosyltransferase glycosyl transferase group 56; Region: Glyco_transf_56; pfam07429 693444013599 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 693444013600 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_10; cd13125 693444013601 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 693444013602 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 693444013603 inhibitor-cofactor binding pocket; inhibition site 693444013604 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693444013605 catalytic residue [active] 693444013606 TDP-fucosamine acetyltransferase; Provisional; Region: PRK10975 693444013607 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 693444013608 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 693444013609 substrate binding site; other site 693444013610 tetramer interface; other site 693444013611 dTDP-glucose 4,6-dehydratase; Provisional; Region: PRK10217 693444013612 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 693444013613 NAD binding site [chemical binding]; other site 693444013614 substrate binding site [chemical binding]; other site 693444013615 homodimer interface [polypeptide binding]; other site 693444013616 active site 693444013617 UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064 693444013618 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 693444013619 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 693444013620 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 693444013621 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 693444013622 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 693444013623 homodimer interface [polypeptide binding]; other site 693444013624 active site 693444013625 lipopolysaccharide biosynthesis protein WzzE; Provisional; Region: PRK11638 693444013626 Chain length determinant protein; Region: Wzz; pfam02706 693444013627 undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase; Provisional; Region: PRK15119 693444013628 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 693444013629 Mg++ binding site [ion binding]; other site 693444013630 putative catalytic motif [active] 693444013631 substrate binding site [chemical binding]; other site 693444013632 transcription termination factor Rho; Provisional; Region: rho; PRK09376 693444013633 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 693444013634 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 693444013635 RNA binding site [nucleotide binding]; other site 693444013636 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 693444013637 multimer interface [polypeptide binding]; other site 693444013638 Walker A motif; other site 693444013639 ATP binding site [chemical binding]; other site 693444013640 Walker B motif; other site 693444013641 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 693444013642 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 693444013643 catalytic residues [active] 693444013644 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 693444013645 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 693444013646 ATP binding site [chemical binding]; other site 693444013647 Mg++ binding site [ion binding]; other site 693444013648 motif III; other site 693444013649 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 693444013650 nucleotide binding region [chemical binding]; other site 693444013651 ATP-binding site [chemical binding]; other site 693444013652 guanosine pentaphosphate phosphohydrolase; Provisional; Region: PRK11031 693444013653 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 693444013654 ATP-dependent DNA helicase Rep; Provisional; Region: PRK10919 693444013655 Part of AAA domain; Region: AAA_19; pfam13245 693444013656 Family description; Region: UvrD_C_2; pfam13538 693444013657 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 693444013658 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 693444013659 peptidyl-prolyl cis-trans isomerase C; Provisional; Region: PRK15441 693444013660 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 693444013661 ketol-acid reductoisomerase; Validated; Region: PRK05225 693444013662 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 693444013663 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 693444013664 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 693444013665 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693444013666 DNA-binding transcriptional regulator IlvY; Provisional; Region: PRK11716 693444013667 The C-terminal substrate binding of LysR-type transcriptional regulator IlvY, which activates the expression of ilvC gene that encoding acetohydroxy acid isomeroreductase for the biosynthesis of branched amino acids; contains the type 2 periplasmic bindin; Region: PBP2_IlvY; cd08430 693444013668 putative dimerization interface [polypeptide binding]; other site 693444013669 threonine dehydratase; Reviewed; Region: PRK09224 693444013670 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 693444013671 tetramer interface [polypeptide binding]; other site 693444013672 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693444013673 catalytic residue [active] 693444013674 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 693444013675 putative Ile/Val binding site [chemical binding]; other site 693444013676 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 693444013677 putative Ile/Val binding site [chemical binding]; other site 693444013678 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 693444013679 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 693444013680 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 693444013681 homodimer interface [polypeptide binding]; other site 693444013682 substrate-cofactor binding pocket; other site 693444013683 catalytic residue [active] 693444013684 acetolactate synthase 2 regulatory subunit; Provisional; Region: ilvM; PRK11152 693444013685 acetolactate synthase 2 catalytic subunit; Reviewed; Region: PRK08978 693444013686 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 693444013687 PYR/PP interface [polypeptide binding]; other site 693444013688 dimer interface [polypeptide binding]; other site 693444013689 TPP binding site [chemical binding]; other site 693444013690 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 693444013691 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 693444013692 TPP-binding site [chemical binding]; other site 693444013693 dimer interface [polypeptide binding]; other site 693444013694 ilvG operon leader peptide; Provisional; Region: PRK10424 693444013695 putative ATP-dependent protease; Provisional; Region: PRK09862 693444013696 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 693444013697 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693444013698 Walker A motif; other site 693444013699 ATP binding site [chemical binding]; other site 693444013700 Walker B motif; other site 693444013701 arginine finger; other site 693444013702 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 693444013703 hypothetical protein; Provisional; Region: PRK11027 693444013704 transcriptional regulator HdfR; Provisional; Region: PRK03601 693444013705 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693444013706 LysR substrate binding domain; Region: LysR_substrate; pfam03466 693444013707 dimerization interface [polypeptide binding]; other site 693444013708 glutamate racemase; Provisional; Region: PRK00865 693444013709 vitamin B12/cobalamin outer membrane transporter; Provisional; Region: btuB; PRK10641 693444013710 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 693444013711 N-terminal plug; other site 693444013712 ligand-binding site [chemical binding]; other site 693444013713 tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031 693444013714 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693444013715 S-adenosylmethionine binding site [chemical binding]; other site 693444013716 hypothetical protein; Provisional; Region: PRK11056 693444013717 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 693444013718 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 693444013719 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 693444013720 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 693444013721 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 693444013722 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 693444013723 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693444013724 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 693444013725 dimerization interface [polypeptide binding]; other site 693444013726 argininosuccinate lyase; Provisional; Region: PRK04833 693444013727 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 693444013728 active sites [active] 693444013729 tetramer interface [polypeptide binding]; other site 693444013730 AAK_NAGK-NC: N-Acetyl-L-glutamate kinase - noncyclic (NAGK-NC) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of microbial arginine biosynthesis using the acetylated, noncyclic route of...; Region: AAK_NAGK-NC; cd04249 693444013731 nucleotide binding site [chemical binding]; other site 693444013732 N-acetyl-L-glutamate binding site [chemical binding]; other site 693444013733 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 693444013734 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 693444013735 acetylornithine deacetylase; Provisional; Region: PRK05111 693444013736 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 693444013737 metal binding site [ion binding]; metal-binding site 693444013738 putative dimer interface [polypeptide binding]; other site 693444013739 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 693444013740 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 693444013741 hypothetical protein; Provisional; Region: PRK10649 693444013742 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 693444013743 Sulfatase; Region: Sulfatase; pfam00884 693444013744 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 693444013745 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 693444013746 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 693444013747 active site 693444013748 P-loop; other site 693444013749 phosphorylation site [posttranslational modification] 693444013750 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 693444013751 active site 693444013752 P-loop; other site 693444013753 phosphorylation site [posttranslational modification] 693444013754 putative PTS system fructose-like transporter subunit EIIC; Provisional; Region: PRK10478 693444013755 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 693444013756 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 693444013757 dimerization domain swap beta strand [polypeptide binding]; other site 693444013758 regulatory protein interface [polypeptide binding]; other site 693444013759 active site 693444013760 regulatory phosphorylation site [posttranslational modification]; other site 693444013761 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 693444013762 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 693444013763 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 693444013764 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 693444013765 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 693444013766 active site 693444013767 phosphorylation site [posttranslational modification] 693444013768 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 693444013769 active site 693444013770 intersubunit interactions; other site 693444013771 catalytic residue [active] 693444013772 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 693444013773 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 693444013774 dimer interface [polypeptide binding]; other site 693444013775 active site 693444013776 metal binding site [ion binding]; metal-binding site 693444013777 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 693444013778 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 693444013779 heme binding site [chemical binding]; other site 693444013780 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 693444013781 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 693444013782 FAD binding site [chemical binding]; other site 693444013783 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693444013784 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693444013785 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 693444013786 dimerization interface [polypeptide binding]; other site 693444013787 substrate binding pocket [chemical binding]; other site 693444013788 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 693444013789 bifunctional aspartate kinase II/homoserine dehydrogenase II; Provisional; Region: metL; PRK09466 693444013790 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 693444013791 putative catalytic residues [active] 693444013792 putative nucleotide binding site [chemical binding]; other site 693444013793 putative aspartate binding site [chemical binding]; other site 693444013794 ACT domains C-terminal to the catalytic domain of aspartokinase (AK; 4-L-aspartate-4-phosphotransferase); Region: ACT_AK-like_2; cd04892 693444013795 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 693444013796 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 693444013797 cystathionine gamma-synthase; Provisional; Region: PRK08045 693444013798 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 693444013799 homodimer interface [polypeptide binding]; other site 693444013800 substrate-cofactor binding pocket; other site 693444013801 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693444013802 catalytic residue [active] 693444013803 Met Repressor, MetJ. MetJ is a bacterial regulatory protein that uses S-adenosylmethionine (SAM) as a corepressor to regulate the production of Methionine. MetJ binds arrays of two to five adjacent copies of an eight base-pair 'metbox'...; Region: Met_repressor_MetJ; cd00490 693444013804 dimerization interface [polypeptide binding]; other site 693444013805 DNA binding site [nucleotide binding] 693444013806 corepressor binding sites; other site 693444013807 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 693444013808 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 693444013809 primosome assembly protein PriA; Validated; Region: PRK05580 693444013810 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 693444013811 ATP binding site [chemical binding]; other site 693444013812 putative Mg++ binding site [ion binding]; other site 693444013813 helicase superfamily c-terminal domain; Region: HELICc; smart00490 693444013814 ATP-binding site [chemical binding]; other site 693444013815 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 693444013816 DNA binding site [nucleotide binding] 693444013817 DNA-binding transcriptional regulator CytR; Provisional; Region: PRK11041 693444013818 domain linker motif; other site 693444013819 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 693444013820 dimerization interface [polypeptide binding]; other site 693444013821 ligand binding site [chemical binding]; other site 693444013822 cell division protein FtsN; Provisional; Region: PRK12757 693444013823 Sporulation related domain; Region: SPOR; cl10051 693444013824 Sporulation related domain; Region: SPOR; cl10051 693444013825 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 693444013826 active site 693444013827 HslU subunit interaction site [polypeptide binding]; other site 693444013828 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 693444013829 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693444013830 Walker A motif; other site 693444013831 ATP binding site [chemical binding]; other site 693444013832 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 693444013833 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 693444013834 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Region: menA; TIGR00751 693444013835 UbiA prenyltransferase family; Region: UbiA; pfam01040 693444013836 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 693444013837 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 693444013838 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 693444013839 active site 693444013840 ADP/pyrophosphate binding site [chemical binding]; other site 693444013841 dimerization interface [polypeptide binding]; other site 693444013842 allosteric effector site; other site 693444013843 fructose-1,6-bisphosphate binding site; other site 693444013844 ferrous iron efflux protein F; Reviewed; Region: fieF; PRK09509 693444013845 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 693444013846 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 693444013847 dimer interface [polypeptide binding]; other site 693444013848 DNA-binding transcriptional regulator CpxR; Provisional; Region: PRK10955 693444013849 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693444013850 active site 693444013851 intermolecular recognition site; other site 693444013852 dimerization interface [polypeptide binding]; other site 693444013853 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 693444013854 DNA binding site [nucleotide binding] 693444013855 two-component sensor protein; Provisional; Region: cpxA; PRK09470 693444013856 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 693444013857 dimerization interface [polypeptide binding]; other site 693444013858 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 693444013859 dimer interface [polypeptide binding]; other site 693444013860 phosphorylation site [posttranslational modification] 693444013861 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693444013862 ATP binding site [chemical binding]; other site 693444013863 Mg2+ binding site [ion binding]; other site 693444013864 G-X-G motif; other site 693444013865 6-N-hydroxylaminopurine resistance protein; Provisional; Region: PRK11536 693444013866 MOSC domain; Region: MOSC; pfam03473 693444013867 3-alpha domain; Region: 3-alpha; pfam03475 693444013868 superoxide dismutase; Provisional; Region: PRK10925 693444013869 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 693444013870 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 693444013871 L-rhamnose-proton symport protein (RhaT); Region: RhaT; cl05728 693444013872 RhaT L-rhamnose-proton symporter family protein; Region: RhaT; TIGR00776 693444013873 transcriptional activator RhaR; Provisional; Region: PRK13502 693444013874 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 693444013875 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 693444013876 transcriptional activator RhaS; Provisional; Region: PRK13503 693444013877 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 693444013878 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 693444013879 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 693444013880 N- and C-terminal domain interface [polypeptide binding]; other site 693444013881 active site 693444013882 putative catalytic site [active] 693444013883 metal binding site [ion binding]; metal-binding site 693444013884 ATP binding site [chemical binding]; other site 693444013885 rhamnulokinase; Provisional; Region: rhaB; PRK10640 693444013886 carbohydrate binding site [chemical binding]; other site 693444013887 L-rhamnose isomerase; Provisional; Region: PRK01076 693444013888 Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900 693444013889 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 693444013890 intersubunit interface [polypeptide binding]; other site 693444013891 active site 693444013892 Zn2+ binding site [ion binding]; other site 693444013893 lactaldehyde reductase; Region: lactal_redase; TIGR02638 693444013894 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 693444013895 dimer interface [polypeptide binding]; other site 693444013896 active site 693444013897 metal binding site [ion binding]; metal-binding site 693444013898 Domain of unknown function (DUF718); Region: DUF718; cl01281 693444013899 Maltoporin periplasmic N-terminal extension; Region: Sugarporin_N; pfam11471 693444013900 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 693444013901 non-specific DNA binding site [nucleotide binding]; other site 693444013902 salt bridge; other site 693444013903 sequence-specific DNA binding site [nucleotide binding]; other site 693444013904 Cupin domain; Region: Cupin_2; cl17218 693444013905 AzlC protein; Region: AzlC; cl00570 693444013906 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 693444013907 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693444013908 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 693444013909 Walker A motif; other site 693444013910 ATP binding site [chemical binding]; other site 693444013911 Walker B motif; other site 693444013912 arginine finger; other site 693444013913 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 693444013914 active pocket/dimerization site; other site 693444013915 active site 693444013916 phosphorylation site [posttranslational modification] 693444013917 PRD domain; Region: PRD; pfam00874 693444013918 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 693444013919 active pocket/dimerization site; other site 693444013920 active site 693444013921 phosphorylation site [posttranslational modification] 693444013922 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 693444013923 PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830 693444013924 active site 693444013925 phosphorylation site [posttranslational modification] 693444013926 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 693444013927 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 693444013928 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_8; cd12167 693444013929 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 693444013930 putative ligand binding site [chemical binding]; other site 693444013931 putative NAD binding site [chemical binding]; other site 693444013932 catalytic site [active] 693444013933 Oligogalacturonate-specific porin protein (KdgM); Region: KdgM; cl11629 693444013934 Protein of unknown function (DUF3829); Region: DUF3829; pfam12889 693444013935 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 693444013936 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 693444013937 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 693444013938 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 693444013939 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 693444013940 molybdopterin cofactor binding site; other site 693444013941 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 693444013942 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 693444013943 formate dehydrogenase-O subunit gamma; Provisional; Region: PRK10639 693444013944 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 693444013945 formate dehydrogenase accessory protein FdhE; Provisional; Region: PRK03564 693444013946 formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562 693444013947 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 693444013948 oligomeric interface; other site 693444013949 putative active site [active] 693444013950 homodimer interface [polypeptide binding]; other site 693444013951 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 693444013952 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 693444013953 non-specific DNA binding site [nucleotide binding]; other site 693444013954 salt bridge; other site 693444013955 sequence-specific DNA binding site [nucleotide binding]; other site 693444013956 Protein of unknown function (DUF1044); Region: DUF1044; cl01955 693444013957 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 693444013958 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 693444013959 substrate binding pocket [chemical binding]; other site 693444013960 Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; cl01912 693444013961 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 693444013962 non-specific DNA binding site [nucleotide binding]; other site 693444013963 salt bridge; other site 693444013964 sequence-specific DNA binding site [nucleotide binding]; other site 693444013965 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 693444013966 Coenzyme A binding pocket [chemical binding]; other site 693444013967 Putative thioesterase (yiiD_Cterm); Region: YiiD_Cterm; pfam09500 693444013968 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 693444013969 putative active site [active] 693444013970 dimerization interface [polypeptide binding]; other site 693444013971 putative tRNAtyr binding site [nucleotide binding]; other site 693444013972 hypothetical protein; Reviewed; Region: PRK01637 693444013973 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 693444013974 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 693444013975 motif II; other site 693444013976 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693444013977 putative substrate translocation pore; other site 693444013978 phosphoglycerate transporter family protein; Region: 2A0104; TIGR00881 693444013979 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 693444013980 transcriptional regulator protein; Region: phnR; TIGR03337 693444013981 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 693444013982 DNA-binding site [nucleotide binding]; DNA binding site 693444013983 UTRA domain; Region: UTRA; pfam07702 693444013984 GTP-binding protein; Provisional; Region: PRK10218 693444013985 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 693444013986 G1 box; other site 693444013987 putative GEF interaction site [polypeptide binding]; other site 693444013988 GTP/Mg2+ binding site [chemical binding]; other site 693444013989 Switch I region; other site 693444013990 G2 box; other site 693444013991 G3 box; other site 693444013992 Switch II region; other site 693444013993 G4 box; other site 693444013994 G5 box; other site 693444013995 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 693444013996 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 693444013997 glutamine synthetase; Provisional; Region: glnA; PRK09469 693444013998 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 693444013999 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 693444014000 nitrogen regulation protein NR(II); Provisional; Region: glnL; PRK11073 693444014001 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 693444014002 putative active site [active] 693444014003 heme pocket [chemical binding]; other site 693444014004 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 693444014005 dimer interface [polypeptide binding]; other site 693444014006 phosphorylation site [posttranslational modification] 693444014007 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693444014008 ATP binding site [chemical binding]; other site 693444014009 Mg2+ binding site [ion binding]; other site 693444014010 G-X-G motif; other site 693444014011 nitrogen regulation protein NR(I); Provisional; Region: glnG; PRK10923 693444014012 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693444014013 active site 693444014014 phosphorylation site [posttranslational modification] 693444014015 intermolecular recognition site; other site 693444014016 dimerization interface [polypeptide binding]; other site 693444014017 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693444014018 Walker A motif; other site 693444014019 ATP binding site [chemical binding]; other site 693444014020 Walker B motif; other site 693444014021 arginine finger; other site 693444014022 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 693444014023 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 693444014024 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 693444014025 FeS/SAM binding site; other site 693444014026 HemN C-terminal domain; Region: HemN_C; pfam06969 693444014027 Der GTPase activator; Provisional; Region: PRK05244 693444014028 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 693444014029 G1 box; other site 693444014030 GTP/Mg2+ binding site [chemical binding]; other site 693444014031 Switch I region; other site 693444014032 G2 box; other site 693444014033 G3 box; other site 693444014034 Switch II region; other site 693444014035 G4 box; other site 693444014036 G5 box; other site 693444014037 DNA polymerase I; Provisional; Region: PRK05755 693444014038 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 693444014039 active site 693444014040 metal binding site 1 [ion binding]; metal-binding site 693444014041 putative 5' ssDNA interaction site; other site 693444014042 metal binding site 3; metal-binding site 693444014043 metal binding site 2 [ion binding]; metal-binding site 693444014044 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 693444014045 putative DNA binding site [nucleotide binding]; other site 693444014046 putative metal binding site [ion binding]; other site 693444014047 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 693444014048 active site 693444014049 catalytic site [active] 693444014050 substrate binding site [chemical binding]; other site 693444014051 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 693444014052 active site 693444014053 DNA binding site [nucleotide binding] 693444014054 catalytic site [active] 693444014055 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 693444014056 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990 693444014057 putative acyl-acceptor binding pocket; other site 693444014058 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339 693444014059 hypothetical protein; Provisional; Region: PRK11367 693444014060 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 693444014061 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 693444014062 catalytic residues [active] 693444014063 hinge region; other site 693444014064 alpha helical domain; other site 693444014065 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 693444014066 serine/threonine protein kinase; Provisional; Region: PRK11768 693444014067 Protein of unknown function (DUF1040); Region: DUF1040; pfam06288 693444014068 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 693444014069 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 693444014070 GTP binding site; other site 693444014071 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 693444014072 Walker A motif; other site 693444014073 transcriptional regulator NanR; Provisional; Region: PRK03837 693444014074 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 693444014075 DNA-binding site [nucleotide binding]; DNA binding site 693444014076 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 693444014077 putative transporter; Provisional; Region: PRK10504 693444014078 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693444014079 putative substrate translocation pore; other site 693444014080 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693444014081 transcriptional repressor RbsR; Provisional; Region: PRK10423 693444014082 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 693444014083 DNA binding site [nucleotide binding] 693444014084 domain linker motif; other site 693444014085 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 693444014086 dimerization interface [polypeptide binding]; other site 693444014087 ligand binding site [chemical binding]; other site 693444014088 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 693444014089 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 693444014090 substrate binding site [chemical binding]; other site 693444014091 dimer interface [polypeptide binding]; other site 693444014092 ATP binding site [chemical binding]; other site 693444014093 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 693444014094 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 693444014095 ligand binding site [chemical binding]; other site 693444014096 dimerization interface [polypeptide binding]; other site 693444014097 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 693444014098 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 693444014099 TM-ABC transporter signature motif; other site 693444014100 D-ribose transporter ATP binding protein; Provisional; Region: PRK10762 693444014101 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 693444014102 Walker A/P-loop; other site 693444014103 ATP binding site [chemical binding]; other site 693444014104 Q-loop/lid; other site 693444014105 ABC transporter signature motif; other site 693444014106 Walker B; other site 693444014107 D-loop; other site 693444014108 H-loop/switch region; other site 693444014109 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 693444014110 D-ribose pyranase; Provisional; Region: PRK11797 693444014111 potassium transport protein Kup; Provisional; Region: trkD; PRK10745 693444014112 potassium uptake protein; Region: kup; TIGR00794 693444014113 regulatory ATPase RavA; Provisional; Region: PRK13531 693444014114 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693444014115 Walker A motif; other site 693444014116 ATP binding site [chemical binding]; other site 693444014117 Walker B motif; other site 693444014118 Protein of unknown function (DUF3763); Region: DUF3763; pfam12592 693444014119 hypothetical protein; Provisional; Region: yieM; PRK10997 693444014120 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 693444014121 metal ion-dependent adhesion site (MIDAS); other site 693444014122 Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia. AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645 693444014123 dimer interface [polypeptide binding]; other site 693444014124 active site 693444014125 DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179 693444014126 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 693444014127 putative DNA binding site [nucleotide binding]; other site 693444014128 putative Zn2+ binding site [ion binding]; other site 693444014129 AsnC family; Region: AsnC_trans_reg; pfam01037 693444014130 FMN-binding protein MioC; Provisional; Region: PRK09004 693444014131 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 693444014132 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 693444014133 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 693444014134 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 693444014135 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693444014136 S-adenosylmethionine binding site [chemical binding]; other site 693444014137 F0F1 ATP synthase subunit I; Validated; Region: PRK08049 693444014138 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 693444014139 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 693444014140 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 693444014141 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 693444014142 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 693444014143 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 693444014144 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 693444014145 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 693444014146 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 693444014147 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 693444014148 beta subunit interaction interface [polypeptide binding]; other site 693444014149 Walker A motif; other site 693444014150 ATP binding site [chemical binding]; other site 693444014151 Walker B motif; other site 693444014152 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 693444014153 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 693444014154 core domain interface [polypeptide binding]; other site 693444014155 delta subunit interface [polypeptide binding]; other site 693444014156 epsilon subunit interface [polypeptide binding]; other site 693444014157 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 693444014158 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 693444014159 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 693444014160 alpha subunit interaction interface [polypeptide binding]; other site 693444014161 Walker A motif; other site 693444014162 ATP binding site [chemical binding]; other site 693444014163 Walker B motif; other site 693444014164 inhibitor binding site; inhibition site 693444014165 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 693444014166 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 693444014167 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 693444014168 gamma subunit interface [polypeptide binding]; other site 693444014169 epsilon subunit interface [polypeptide binding]; other site 693444014170 LBP interface [polypeptide binding]; other site 693444014171 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 693444014172 Inhibitor of apoptosis-promoting Bax1; Region: Bax1-I; pfam01027 693444014173 Right handed beta helix region; Region: Beta_helix; pfam13229 693444014174 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK09451 693444014175 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 693444014176 Substrate binding site; other site 693444014177 Mg++ binding site; other site 693444014178 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 693444014179 active site 693444014180 substrate binding site [chemical binding]; other site 693444014181 CoA binding site [chemical binding]; other site 693444014182 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 693444014183 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 693444014184 glutaminase active site [active] 693444014185 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 693444014186 dimer interface [polypeptide binding]; other site 693444014187 active site 693444014188 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 693444014189 dimer interface [polypeptide binding]; other site 693444014190 active site 693444014191 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 693444014192 phosphate transporter permease subunit PstC; Provisional; Region: pstC; PRK11275 693444014193 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693444014194 dimer interface [polypeptide binding]; other site 693444014195 conserved gate region; other site 693444014196 putative PBP binding loops; other site 693444014197 ABC-ATPase subunit interface; other site 693444014198 phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268 693444014199 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693444014200 dimer interface [polypeptide binding]; other site 693444014201 conserved gate region; other site 693444014202 putative PBP binding loops; other site 693444014203 ABC-ATPase subunit interface; other site 693444014204 phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744 693444014205 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 693444014206 Walker A/P-loop; other site 693444014207 ATP binding site [chemical binding]; other site 693444014208 Q-loop/lid; other site 693444014209 ABC transporter signature motif; other site 693444014210 Walker B; other site 693444014211 D-loop; other site 693444014212 H-loop/switch region; other site 693444014213 transcriptional regulator PhoU; Provisional; Region: PRK11115 693444014214 PhoU domain; Region: PhoU; pfam01895 693444014215 PhoU domain; Region: PhoU; pfam01895 693444014216 6-phosphogluconate phosphatase; Provisional; Region: PRK10563 693444014217 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 693444014218 active site 693444014219 motif I; other site 693444014220 motif II; other site 693444014221 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 693444014222 Predicted flavoprotein [General function prediction only]; Region: COG0431 693444014223 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 693444014224 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 693444014225 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 693444014226 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 693444014227 trmE is a tRNA modification GTPase; Region: trmE; cd04164 693444014228 G1 box; other site 693444014229 GTP/Mg2+ binding site [chemical binding]; other site 693444014230 Switch I region; other site 693444014231 G2 box; other site 693444014232 Switch II region; other site 693444014233 G3 box; other site 693444014234 G4 box; other site 693444014235 G5 box; other site 693444014236 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 693444014237 membrane protein insertase; Provisional; Region: PRK01318 693444014238 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 693444014239 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 693444014240 hypothetical protein; Validated; Region: PRK00041 693444014241 ribonuclease P; Reviewed; Region: rnpA; PRK01732 693444014242 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399