-- dump date 20140619_073813 -- class Genbank::misc_feature -- table misc_feature_note -- id note 657310000001 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 657310000002 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 657310000003 active site 657310000004 phosphorylation site [posttranslational modification] 657310000005 intermolecular recognition site; other site 657310000006 dimerization interface [polypeptide binding]; other site 657310000007 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 657310000008 DNA binding site [nucleotide binding] 657310000009 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 657310000010 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 657310000011 dimer interface [polypeptide binding]; other site 657310000012 phosphorylation site [posttranslational modification] 657310000013 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 657310000014 ATP binding site [chemical binding]; other site 657310000015 Mg2+ binding site [ion binding]; other site 657310000016 G-X-G motif; other site 657310000017 seryl-tRNA synthetase; Provisional; Region: PRK05431 657310000018 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 657310000019 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 657310000020 dimer interface [polypeptide binding]; other site 657310000021 active site 657310000022 motif 1; other site 657310000023 motif 2; other site 657310000024 motif 3; other site 657310000025 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 657310000026 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 657310000027 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 657310000028 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 657310000029 active site 657310000030 6-pyruvoyl-tetrahydropterin synthase related domain; membrane protein; Region: PTPS_related; pfam10131 657310000031 Protein of unknown function (DUF1129); Region: DUF1129; pfam06570 657310000032 GTP-binding protein YchF; Reviewed; Region: PRK09601 657310000033 YchF GTPase; Region: YchF; cd01900 657310000034 G1 box; other site 657310000035 GTP/Mg2+ binding site [chemical binding]; other site 657310000036 Switch I region; other site 657310000037 G2 box; other site 657310000038 Switch II region; other site 657310000039 G3 box; other site 657310000040 G4 box; other site 657310000041 G5 box; other site 657310000042 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 657310000043 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 657310000044 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 657310000045 ParB-like nuclease domain; Region: ParBc; pfam02195 657310000046 KorB domain; Region: KorB; pfam08535 657310000047 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 657310000048 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 657310000049 P-loop; other site 657310000050 Magnesium ion binding site [ion binding]; other site 657310000051 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 657310000052 Magnesium ion binding site [ion binding]; other site 657310000053 Protein of unknown function (DUF3114); Region: DUF3114; pfam11311 657310000054 myosin-cross-reactive antigen; Provisional; Region: PRK13977 657310000055 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 657310000056 active site 657310000057 intersubunit interactions; other site 657310000058 catalytic residue [active] 657310000059 PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; pfam03829 657310000060 PTS system, glucitol/sorbitol-specific, IIBC component; Region: EIIBC-GUT; TIGR00825 657310000061 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 657310000062 Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663 657310000063 PTS system enzyme II sorbitol-specific factor; Region: EII-GUT; pfam03608 657310000064 Glucitol operon activator protein (GutM); Region: GutM; pfam06923 657310000065 HTH domain; Region: HTH_11; pfam08279 657310000066 HTH domain; Region: HTH_11; pfam08279 657310000067 PRD domain; Region: PRD; pfam00874 657310000068 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 657310000069 active site 657310000070 P-loop; other site 657310000071 phosphorylation site [posttranslational modification] 657310000072 Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2; Region: PTS_EIIA_2; pfam00359 657310000073 active site 657310000074 phosphorylation site [posttranslational modification] 657310000075 sorbitol-6-phosphate 2-dehydrogenase; Provisional; Region: PRK06171 657310000076 classical (c) SDRs; Region: SDR_c; cd05233 657310000077 NAD(P) binding site [chemical binding]; other site 657310000078 active site 657310000079 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 657310000080 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 657310000081 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 657310000082 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 657310000083 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 657310000084 trmE is a tRNA modification GTPase; Region: trmE; cd04164 657310000085 G1 box; other site 657310000086 GTP/Mg2+ binding site [chemical binding]; other site 657310000087 Switch I region; other site 657310000088 G2 box; other site 657310000089 Switch II region; other site 657310000090 G3 box; other site 657310000091 G4 box; other site 657310000092 G5 box; other site 657310000093 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 657310000094 ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; cl00768 657310000095 2'-(5''-triphosphoribosyl)-3'- dephospho-CoA:apo-citrate lyase; Reviewed; Region: citX; PRK01392 657310000096 Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051 657310000097 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 657310000098 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06549 657310000099 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 657310000100 carboxyltransferase (CT) interaction site; other site 657310000101 biotinylation site [posttranslational modification]; other site 657310000102 H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851 657310000103 Citrate transporter; Region: CitMHS; pfam03600 657310000104 Transcriptional regulators [Transcription]; Region: FadR; COG2186 657310000105 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 657310000106 DNA-binding site [nucleotide binding]; DNA binding site 657310000107 FCD domain; Region: FCD; pfam07729 657310000108 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 657310000109 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 657310000110 active site 657310000111 phosphorylation site [posttranslational modification] 657310000112 intermolecular recognition site; other site 657310000113 dimerization interface [polypeptide binding]; other site 657310000114 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 657310000115 DNA binding site [nucleotide binding] 657310000116 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 657310000117 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 657310000118 G-X-X-G motif; other site 657310000119 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 657310000120 RxxxH motif; other site 657310000121 ribonuclease P; Reviewed; Region: rnpA; PRK00499 657310000122 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 657310000123 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 657310000124 DnaA N-terminal domain; Region: DnaA_N; pfam11638 657310000125 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 657310000126 Walker A motif; other site 657310000127 ATP binding site [chemical binding]; other site 657310000128 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 657310000129 Walker B motif; other site 657310000130 arginine finger; other site 657310000131 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 657310000132 DnaA box-binding interface [nucleotide binding]; other site 657310000133 DNA polymerase III subunit beta; Validated; Region: PRK05643 657310000134 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 657310000135 putative DNA binding surface [nucleotide binding]; other site 657310000136 dimer interface [polypeptide binding]; other site 657310000137 beta-clamp/clamp loader binding surface; other site 657310000138 beta-clamp/translesion DNA polymerase binding surface; other site 657310000139 recombination protein F; Reviewed; Region: recF; PRK00064 657310000140 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 657310000141 Walker A/P-loop; other site 657310000142 ATP binding site [chemical binding]; other site 657310000143 Q-loop/lid; other site 657310000144 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 657310000145 ABC transporter signature motif; other site 657310000146 Walker B; other site 657310000147 D-loop; other site 657310000148 H-loop/switch region; other site 657310000149 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 657310000150 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 657310000151 Mg2+ binding site [ion binding]; other site 657310000152 G-X-G motif; other site 657310000153 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 657310000154 anchoring element; other site 657310000155 dimer interface [polypeptide binding]; other site 657310000156 ATP binding site [chemical binding]; other site 657310000157 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 657310000158 active site 657310000159 putative metal-binding site [ion binding]; other site 657310000160 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 657310000161 DNA gyrase subunit A; Validated; Region: PRK05560 657310000162 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 657310000163 CAP-like domain; other site 657310000164 active site 657310000165 primary dimer interface [polypeptide binding]; other site 657310000166 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 657310000167 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 657310000168 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 657310000169 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 657310000170 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 657310000171 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 657310000172 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 657310000173 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 657310000174 dimer interface [polypeptide binding]; other site 657310000175 ssDNA binding site [nucleotide binding]; other site 657310000176 tetramer (dimer of dimers) interface [polypeptide binding]; other site 657310000177 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 657310000178 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 657310000179 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 657310000180 DHH family; Region: DHH; pfam01368 657310000181 DHHA1 domain; Region: DHHA1; pfam02272 657310000182 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 657310000183 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 657310000184 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 657310000185 replicative DNA helicase; Provisional; Region: PRK05748 657310000186 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 657310000187 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 657310000188 Walker A motif; other site 657310000189 ATP binding site [chemical binding]; other site 657310000190 Walker B motif; other site 657310000191 DNA binding loops [nucleotide binding] 657310000192 Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775 657310000193 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 657310000194 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 657310000195 Walker A motif; other site 657310000196 ATP binding site [chemical binding]; other site 657310000197 Walker B motif; other site 657310000198 arginine finger; other site 657310000199 Transcriptional antiterminator [Transcription]; Region: COG3933 657310000200 PRD domain; Region: PRD; pfam00874 657310000201 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 657310000202 active pocket/dimerization site; other site 657310000203 active site 657310000204 phosphorylation site [posttranslational modification] 657310000205 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cd00133 657310000206 active site 657310000207 P-loop; other site 657310000208 phosphorylation site [posttranslational modification] 657310000209 PRD domain; Region: PRD; pfam00874 657310000210 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 657310000211 active site 657310000212 phosphorylation site [posttranslational modification] 657310000213 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 657310000214 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 657310000215 active pocket/dimerization site; other site 657310000216 active site 657310000217 phosphorylation site [posttranslational modification] 657310000218 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 657310000219 active site 657310000220 phosphorylation site [posttranslational modification] 657310000221 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 657310000222 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 657310000223 Domain of unknown function (DUF956); Region: DUF956; pfam06115 657310000224 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 657310000225 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 657310000226 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 657310000227 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 657310000228 putative active site [active] 657310000229 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl17885 657310000230 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 657310000231 homotrimer interaction site [polypeptide binding]; other site 657310000232 putative active site [active] 657310000233 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 657310000234 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 657310000235 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 657310000236 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 657310000237 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 657310000238 NAD binding site [chemical binding]; other site 657310000239 sugar binding site [chemical binding]; other site 657310000240 divalent metal binding site [ion binding]; other site 657310000241 tetramer (dimer of dimers) interface [polypeptide binding]; other site 657310000242 dimer interface [polypeptide binding]; other site 657310000243 Predicted integral membrane protein [Function unknown]; Region: COG0392 657310000244 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 657310000245 Uncharacterized conserved protein [Function unknown]; Region: COG2898 657310000246 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 657310000247 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 657310000248 Protein of unknown function (DUF1706); Region: DUF1706; pfam08020 657310000249 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 657310000250 dimer interface [polypeptide binding]; other site 657310000251 Predicted transcriptional regulator [Transcription]; Region: COG2378 657310000252 HTH domain; Region: HTH_11; pfam08279 657310000253 WYL domain; Region: WYL; pfam13280 657310000254 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 657310000255 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 657310000256 putative catalytic cysteine [active] 657310000257 Glutamate 5-kinase [Amino acid transport and metabolism]; Region: ProB; COG0263 657310000258 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 657310000259 nucleotide binding site [chemical binding]; other site 657310000260 homotetrameric interface [polypeptide binding]; other site 657310000261 putative phosphate binding site [ion binding]; other site 657310000262 putative allosteric binding site; other site 657310000263 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 657310000264 trimer interface [polypeptide binding]; other site 657310000265 active site 657310000266 DNA repair protein RadA; Provisional; Region: PRK11823 657310000267 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 657310000268 Walker A motif/ATP binding site; other site 657310000269 ATP binding site [chemical binding]; other site 657310000270 Walker B motif; other site 657310000271 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 657310000272 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 657310000273 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 657310000274 putative active site [active] 657310000275 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 657310000276 homotrimer interaction site [polypeptide binding]; other site 657310000277 zinc binding site [ion binding]; other site 657310000278 CDP-binding sites; other site 657310000279 serine O-acetyltransferase; Region: cysE; TIGR01172 657310000280 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 657310000281 trimer interface [polypeptide binding]; other site 657310000282 active site 657310000283 substrate binding site [chemical binding]; other site 657310000284 CoA binding site [chemical binding]; other site 657310000285 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 657310000286 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 657310000287 active site 657310000288 HIGH motif; other site 657310000289 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 657310000290 KMSKS motif; other site 657310000291 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 657310000292 tRNA binding surface [nucleotide binding]; other site 657310000293 anticodon binding site; other site 657310000294 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 657310000295 active site 657310000296 metal binding site [ion binding]; metal-binding site 657310000297 dimerization interface [polypeptide binding]; other site 657310000298 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 657310000299 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 657310000300 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 657310000301 YacP-like NYN domain; Region: NYN_YacP; pfam05991 657310000302 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 657310000303 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 657310000304 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 657310000305 DNA binding residues [nucleotide binding] 657310000306 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 657310000307 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 657310000308 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 657310000309 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 657310000310 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 657310000311 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 657310000312 metal binding site [ion binding]; metal-binding site 657310000313 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 657310000314 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 657310000315 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 657310000316 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 657310000317 ABC-ATPase subunit interface; other site 657310000318 dimer interface [polypeptide binding]; other site 657310000319 putative PBP binding regions; other site 657310000320 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 657310000321 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 657310000322 peptide binding site [polypeptide binding]; other site 657310000323 Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979 657310000324 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 657310000325 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 657310000326 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 657310000327 Abi-like protein; Region: Abi_2; pfam07751 657310000328 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 657310000329 RuvA N terminal domain; Region: RuvA_N; pfam01330 657310000330 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 657310000331 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 657310000332 Walker A motif; other site 657310000333 ATP binding site [chemical binding]; other site 657310000334 Walker B motif; other site 657310000335 arginine finger; other site 657310000336 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 657310000337 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 657310000338 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 657310000339 putative active site cavity [active] 657310000340 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 657310000341 non-specific DNA binding site [nucleotide binding]; other site 657310000342 salt bridge; other site 657310000343 sequence-specific DNA binding site [nucleotide binding]; other site 657310000344 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 657310000345 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 657310000346 ligand binding site [chemical binding]; other site 657310000347 flexible hinge region; other site 657310000348 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 657310000349 oxidoreductase; Provisional; Region: PRK07985 657310000350 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 657310000351 NAD(P) binding site [chemical binding]; other site 657310000352 active site 657310000353 Small integral membrane protein (DUF2273); Region: DUF2273; cl11575 657310000354 Asp23 family; Region: Asp23; pfam03780 657310000355 Asp23 family; Region: Asp23; pfam03780 657310000356 Predicted membrane protein [Function unknown]; Region: COG2261 657310000357 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 657310000358 Major Facilitator Superfamily; Region: MFS_1; pfam07690 657310000359 putative substrate translocation pore; other site 657310000360 Mga helix-turn-helix domain; Region: Mga; pfam05043 657310000361 Mga helix-turn-helix domain; Region: Mga; pfam05043 657310000362 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 657310000363 Collagen binding domain; Region: Collagen_bind; pfam05737 657310000364 Collagen binding domain; Region: Collagen_bind; pfam05737 657310000365 Collagen binding domain; Region: Collagen_bind; pfam05737 657310000366 Collagen binding domain; Region: Collagen_bind; pfam05737 657310000367 Collagen binding domain; Region: Collagen_bind; pfam05737 657310000368 Cna protein B-type domain; Region: Cna_B; pfam05738 657310000369 Cna protein B-type domain; Region: Cna_B; pfam05738 657310000370 Cna protein B-type domain; Region: Cna_B; pfam05738 657310000371 Cna protein B-type domain; Region: Cna_B; pfam05738 657310000372 Cna protein B-type domain; Region: Cna_B; pfam05738 657310000373 Cna protein B-type domain; Region: Cna_B; pfam05738 657310000374 Cna protein B-type domain; Region: Cna_B; pfam05738 657310000375 Cna protein B-type domain; Region: Cna_B; pfam05738 657310000376 Cna protein B-type domain; Region: Cna_B; pfam05738 657310000377 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 657310000378 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 657310000379 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425 657310000380 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 657310000381 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 657310000382 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 657310000383 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 657310000384 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 657310000385 seryl-tRNA synthetase; Provisional; Region: PRK05431 657310000386 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 657310000387 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 657310000388 dimer interface [polypeptide binding]; other site 657310000389 active site 657310000390 motif 1; other site 657310000391 motif 2; other site 657310000392 motif 3; other site 657310000393 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 657310000394 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 657310000395 Arginine repressor [Transcription]; Region: ArgR; COG1438 657310000396 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 657310000397 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 657310000398 arginine deiminase; Provisional; Region: PRK01388 657310000399 ornithine carbamoyltransferase; Validated; Region: PRK02102 657310000400 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 657310000401 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 657310000402 carbamate kinase; Reviewed; Region: PRK12686 657310000403 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 657310000404 putative substrate binding site [chemical binding]; other site 657310000405 nucleotide binding site [chemical binding]; other site 657310000406 nucleotide binding site [chemical binding]; other site 657310000407 homodimer interface [polypeptide binding]; other site 657310000408 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 657310000409 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 657310000410 ligand binding site [chemical binding]; other site 657310000411 flexible hinge region; other site 657310000412 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 657310000413 putative switch regulator; other site 657310000414 non-specific DNA interactions [nucleotide binding]; other site 657310000415 DNA binding site [nucleotide binding] 657310000416 sequence specific DNA binding site [nucleotide binding]; other site 657310000417 putative cAMP binding site [chemical binding]; other site 657310000418 Predicted membrane protein [Function unknown]; Region: COG1288 657310000419 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 657310000420 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 657310000421 potential catalytic triad [active] 657310000422 conserved cys residue [active] 657310000423 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 657310000424 dimerization interface [polypeptide binding]; other site 657310000425 putative DNA binding site [nucleotide binding]; other site 657310000426 putative Zn2+ binding site [ion binding]; other site 657310000427 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 657310000428 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 657310000429 putative NAD(P) binding site [chemical binding]; other site 657310000430 Endo-beta-N-acetylglucosaminidases are bacterial chitinases that hydrolyze the chitin core of various asparagine (N)-linked glycans and glycoproteins. The endo-beta-N-acetylglucosaminidases have a glycosyl hydrolase family 18 (GH18) catalytic domain; Region: GH18_EndoS-like; cd06542 657310000431 active site 657310000432 Glycosyl hydrolase family 20 (GH20) catalytic domain of dispersin B (DspB), lacto-N-biosidase (LnbB) and related proteins. Dispersin B is a soluble beta-N-acetylglucosamidase found in bacteria that hydrolyzes the beta-1,6-linkages of PGA (poly-beta-(1,6)...; Region: GH20_DspB_LnbB-like; cd06564 657310000433 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 657310000434 active site 657310000435 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 657310000436 homotrimer interaction site [polypeptide binding]; other site 657310000437 putative active site [active] 657310000438 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 657310000439 homotrimer interaction site [polypeptide binding]; other site 657310000440 putative active site [active] 657310000441 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 657310000442 homotrimer interaction site [polypeptide binding]; other site 657310000443 putative active site [active] 657310000444 MepB protein; Region: MepB; pfam08877 657310000445 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 657310000446 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 657310000447 DNA-binding site [nucleotide binding]; DNA binding site 657310000448 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 657310000449 pyridoxal 5'-phosphate binding site [chemical binding]; other site 657310000450 homodimer interface [polypeptide binding]; other site 657310000451 catalytic residue [active] 657310000452 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 657310000453 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 657310000454 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 657310000455 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; cl00920 657310000456 AP2 domain; Region: AP2; pfam00847 657310000457 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 657310000458 Int/Topo IB signature motif; other site 657310000459 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 657310000460 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 657310000461 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 657310000462 active site 657310000463 metal binding site [ion binding]; metal-binding site 657310000464 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 657310000465 Int/Topo IB signature motif; other site 657310000466 Domain of unknown function (DUF3173); Region: DUF3173; pfam11372 657310000467 Replication initiation factor; Region: Rep_trans; pfam02486 657310000468 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 657310000469 Mga helix-turn-helix domain; Region: Mga; pfam05043 657310000470 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 657310000471 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 657310000472 non-specific DNA binding site [nucleotide binding]; other site 657310000473 salt bridge; other site 657310000474 sequence-specific DNA binding site [nucleotide binding]; other site 657310000475 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 657310000476 non-specific DNA binding site [nucleotide binding]; other site 657310000477 salt bridge; other site 657310000478 sequence-specific DNA binding site [nucleotide binding]; other site 657310000479 Bacterial protein of unknown function (DUF961); Region: DUF961; pfam06125 657310000480 Beta protein; Region: Beta_protein; pfam14350 657310000481 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 657310000482 active site 657310000483 NTP binding site [chemical binding]; other site 657310000484 metal binding triad [ion binding]; metal-binding site 657310000485 antibiotic binding site [chemical binding]; other site 657310000486 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 657310000487 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098 657310000488 active site 657310000489 catalytic site [active] 657310000490 Conjugative transposon protein TcpC; Region: TpcC; pfam12642 657310000491 AAA-like domain; Region: AAA_10; pfam12846 657310000492 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 657310000493 Walker A motif; other site 657310000494 ATP binding site [chemical binding]; other site 657310000495 CHAP domain; Region: CHAP; cl17642 657310000496 Domain of unknown function (DUF3173); Region: DUF3173; pfam11372 657310000497 pantothenate kinase; Provisional; Region: PRK05439 657310000498 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 657310000499 ATP-binding site [chemical binding]; other site 657310000500 CoA-binding site [chemical binding]; other site 657310000501 Mg2+-binding site [ion binding]; other site 657310000502 Isoamyl-acetate hydrolyzing esterase-like proteins. SGNH_hydrolase subfamily similar to the Saccharomyces cerevisiae IAH1. IAH1 may be the major esterase that hydrolyses isoamyl acetate in sake mash. The SGNH-family of hydrolases is a diverse family of...; Region: Isoamyl_acetate_hydrolase_like; cd01838 657310000503 catalytic triad [active] 657310000504 oxyanion hole [active] 657310000505 active site 657310000506 Methyltransferase domain; Region: Methyltransf_31; pfam13847 657310000507 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 657310000508 S-adenosylmethionine binding site [chemical binding]; other site 657310000509 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 657310000510 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 657310000511 active site 657310000512 purine riboside binding site [chemical binding]; other site 657310000513 Transcriptional regulators [Transcription]; Region: PurR; COG1609 657310000514 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 657310000515 DNA binding site [nucleotide binding] 657310000516 domain linker motif; other site 657310000517 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 657310000518 dimerization interface [polypeptide binding]; other site 657310000519 ligand binding site [chemical binding]; other site 657310000520 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 657310000521 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 657310000522 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 657310000523 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 657310000524 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 657310000525 intersubunit interface [polypeptide binding]; other site 657310000526 active site 657310000527 catalytic residue [active] 657310000528 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 657310000529 active site 657310000530 catalytic motif [active] 657310000531 Zn binding site [ion binding]; other site 657310000532 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 657310000533 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 657310000534 ligand binding site [chemical binding]; other site 657310000535 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 657310000536 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 657310000537 TM-ABC transporter signature motif; other site 657310000538 Protein of unknown function (DUF1211); Region: DUF1211; cl01421 657310000539 purine nucleoside phosphorylase; Provisional; Region: PRK08202 657310000540 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 657310000541 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 657310000542 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 657310000543 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 657310000544 putative ligand binding residues [chemical binding]; other site 657310000545 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 657310000546 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 657310000547 Walker A/P-loop; other site 657310000548 ATP binding site [chemical binding]; other site 657310000549 Q-loop/lid; other site 657310000550 ABC transporter signature motif; other site 657310000551 Walker B; other site 657310000552 D-loop; other site 657310000553 H-loop/switch region; other site 657310000554 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 657310000555 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 657310000556 ABC-ATPase subunit interface; other site 657310000557 dimer interface [polypeptide binding]; other site 657310000558 putative PBP binding regions; other site 657310000559 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 657310000560 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 657310000561 dimer interface [polypeptide binding]; other site 657310000562 putative PBP binding regions; other site 657310000563 ABC-ATPase subunit interface; other site 657310000564 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 657310000565 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 657310000566 dimer interface [polypeptide binding]; other site 657310000567 active site 657310000568 metal binding site [ion binding]; metal-binding site 657310000569 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 657310000570 catalytic core [active] 657310000571 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 657310000572 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 657310000573 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 657310000574 catalytic residues [active] 657310000575 catalytic nucleophile [active] 657310000576 Presynaptic Site I dimer interface [polypeptide binding]; other site 657310000577 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 657310000578 Synaptic Flat tetramer interface [polypeptide binding]; other site 657310000579 Synaptic Site I dimer interface [polypeptide binding]; other site 657310000580 DNA binding site [nucleotide binding] 657310000581 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 657310000582 tetramer (dimer of dimers) interface [polypeptide binding]; other site 657310000583 active site 657310000584 dimer interface [polypeptide binding]; other site 657310000585 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 657310000586 S17 interaction site [polypeptide binding]; other site 657310000587 S8 interaction site; other site 657310000588 16S rRNA interaction site [nucleotide binding]; other site 657310000589 streptomycin interaction site [chemical binding]; other site 657310000590 23S rRNA interaction site [nucleotide binding]; other site 657310000591 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 657310000592 30S ribosomal protein S7; Validated; Region: PRK05302 657310000593 elongation factor G; Reviewed; Region: PRK00007 657310000594 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 657310000595 G1 box; other site 657310000596 putative GEF interaction site [polypeptide binding]; other site 657310000597 GTP/Mg2+ binding site [chemical binding]; other site 657310000598 Switch I region; other site 657310000599 G2 box; other site 657310000600 G3 box; other site 657310000601 Switch II region; other site 657310000602 G4 box; other site 657310000603 G5 box; other site 657310000604 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 657310000605 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 657310000606 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 657310000607 elongation factor Tu; Reviewed; Region: PRK00049 657310000608 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 657310000609 G1 box; other site 657310000610 GEF interaction site [polypeptide binding]; other site 657310000611 GTP/Mg2+ binding site [chemical binding]; other site 657310000612 Switch I region; other site 657310000613 G2 box; other site 657310000614 G3 box; other site 657310000615 Switch II region; other site 657310000616 G4 box; other site 657310000617 G5 box; other site 657310000618 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 657310000619 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 657310000620 Antibiotic Binding Site [chemical binding]; other site 657310000621 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 657310000622 dimer interface [polypeptide binding]; other site 657310000623 substrate binding site [chemical binding]; other site 657310000624 ATP binding site [chemical binding]; other site 657310000625 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 657310000626 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 657310000627 S-adenosylmethionine binding site [chemical binding]; other site 657310000628 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 657310000629 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 657310000630 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 657310000631 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 657310000632 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 657310000633 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 657310000634 putative translocon binding site; other site 657310000635 protein-rRNA interface [nucleotide binding]; other site 657310000636 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 657310000637 23S rRNA interface [nucleotide binding]; other site 657310000638 5S rRNA interface [nucleotide binding]; other site 657310000639 putative antibiotic binding site [chemical binding]; other site 657310000640 L25 interface [polypeptide binding]; other site 657310000641 L27 interface [polypeptide binding]; other site 657310000642 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 657310000643 23S rRNA interface [nucleotide binding]; other site 657310000644 putative translocon interaction site; other site 657310000645 signal recognition particle (SRP54) interaction site; other site 657310000646 L23 interface [polypeptide binding]; other site 657310000647 trigger factor interaction site; other site 657310000648 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 657310000649 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 657310000650 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 657310000651 RNA binding site [nucleotide binding]; other site 657310000652 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 657310000653 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 657310000654 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 657310000655 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 657310000656 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 657310000657 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 657310000658 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 657310000659 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 657310000660 23S rRNA binding site [nucleotide binding]; other site 657310000661 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 657310000662 adenylate kinase; Reviewed; Region: adk; PRK00279 657310000663 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 657310000664 AMP-binding site [chemical binding]; other site 657310000665 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 657310000666 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 657310000667 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 657310000668 30S ribosomal protein S13; Region: bact_S13; TIGR03631 657310000669 30S ribosomal protein S11; Validated; Region: PRK05309 657310000670 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 657310000671 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 657310000672 alphaNTD homodimer interface [polypeptide binding]; other site 657310000673 alphaNTD - beta interaction site [polypeptide binding]; other site 657310000674 alphaNTD - beta' interaction site [polypeptide binding]; other site 657310000675 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 657310000676 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 657310000677 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_subfamily5; cd08019 657310000678 metal binding site [ion binding]; metal-binding site 657310000679 putative dimer interface [polypeptide binding]; other site 657310000680 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635 657310000681 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 657310000682 Walker A/P-loop; other site 657310000683 ATP binding site [chemical binding]; other site 657310000684 Q-loop/lid; other site 657310000685 ABC transporter signature motif; other site 657310000686 Walker B; other site 657310000687 D-loop; other site 657310000688 H-loop/switch region; other site 657310000689 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13634 657310000690 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 657310000691 Walker A/P-loop; other site 657310000692 ATP binding site [chemical binding]; other site 657310000693 Q-loop/lid; other site 657310000694 ABC transporter signature motif; other site 657310000695 Walker B; other site 657310000696 D-loop; other site 657310000697 H-loop/switch region; other site 657310000698 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 657310000699 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 657310000700 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 657310000701 dimerization interface 3.5A [polypeptide binding]; other site 657310000702 active site 657310000703 hypothetical protein; Provisional; Region: PRK00967 657310000704 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 657310000705 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 657310000706 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 657310000707 Walker A/P-loop; other site 657310000708 ATP binding site [chemical binding]; other site 657310000709 Q-loop/lid; other site 657310000710 ABC transporter signature motif; other site 657310000711 Walker B; other site 657310000712 D-loop; other site 657310000713 H-loop/switch region; other site 657310000714 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 657310000715 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 657310000716 substrate binding pocket [chemical binding]; other site 657310000717 membrane-bound complex binding site; other site 657310000718 hinge residues; other site 657310000719 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 657310000720 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 657310000721 dimer interface [polypeptide binding]; other site 657310000722 conserved gate region; other site 657310000723 putative PBP binding loops; other site 657310000724 ABC-ATPase subunit interface; other site 657310000725 NAD-dependent deacetylase; Provisional; Region: PRK00481 657310000726 SIR2H: Uncharacterized prokaryotic Sir2 homologs from several gram positive bacterial species and Fusobacteria; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone...; Region: SIR2H; cd01411 657310000727 NAD+ binding site [chemical binding]; other site 657310000728 substrate binding site [chemical binding]; other site 657310000729 putative Zn binding site [ion binding]; other site 657310000730 maltose O-acetyltransferase; Provisional; Region: PRK10092 657310000731 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 657310000732 active site 657310000733 substrate binding site [chemical binding]; other site 657310000734 trimer interface [polypeptide binding]; other site 657310000735 CoA binding site [chemical binding]; other site 657310000736 monofunctional chorismate mutase, gram positive-type, clade 2; Region: CM_mono_grmpos; TIGR01805 657310000737 E4 protein; Provisional; Region: PHA03420 657310000738 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 657310000739 CHAP domain; Region: CHAP; pfam05257 657310000740 Uncharacterized Staphylococcus aureus AldA1 (SACOL0154) aldehyde dehydrogenase-like; Region: ALDH_StaphAldA1; cd07117 657310000741 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 657310000742 NAD(P) binding site [chemical binding]; other site 657310000743 catalytic residues [active] 657310000744 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 657310000745 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 657310000746 tetramer (dimer of dimers) interface [polypeptide binding]; other site 657310000747 NAD binding site [chemical binding]; other site 657310000748 dimer interface [polypeptide binding]; other site 657310000749 substrate binding site [chemical binding]; other site 657310000750 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 657310000751 putative active site [active] 657310000752 catalytic residue [active] 657310000753 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 657310000754 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 657310000755 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 657310000756 RNA binding surface [nucleotide binding]; other site 657310000757 hypothetical protein; Provisional; Region: PRK08582 657310000758 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 657310000759 RNA binding site [nucleotide binding]; other site 657310000760 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 657310000761 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 657310000762 Ligand Binding Site [chemical binding]; other site 657310000763 TilS substrate C-terminal domain; Region: TilS_C; smart00977 657310000764 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 657310000765 active site 657310000766 FtsH Extracellular; Region: FtsH_ext; pfam06480 657310000767 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 657310000768 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 657310000769 Walker A motif; other site 657310000770 ATP binding site [chemical binding]; other site 657310000771 Walker B motif; other site 657310000772 arginine finger; other site 657310000773 Peptidase family M41; Region: Peptidase_M41; pfam01434 657310000774 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 657310000775 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 657310000776 dimerization interface [polypeptide binding]; other site 657310000777 domain crossover interface; other site 657310000778 redox-dependent activation switch; other site 657310000779 PrgI family protein; Region: PrgI; pfam12666 657310000780 AAA-like domain; Region: AAA_10; pfam12846 657310000781 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 657310000782 N-acetyl-D-glucosamine binding site [chemical binding]; other site 657310000783 catalytic residue [active] 657310000784 CHAP domain; Region: CHAP; pfam05257 657310000785 Type IV secretory system Conjugative DNA transfer; Region: T4SS-DNA_transf; pfam02534 657310000786 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 657310000787 Walker A motif; other site 657310000788 ATP binding site [chemical binding]; other site 657310000789 Walker B motif; other site 657310000790 Primase C terminal 1 (PriCT-1); Region: PriCT_1; pfam08708 657310000791 Transcriptional regulator; Region: Rrf2; cl17282 657310000792 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 657310000793 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 657310000794 catalytic residues [active] 657310000795 catalytic nucleophile [active] 657310000796 Presynaptic Site I dimer interface [polypeptide binding]; other site 657310000797 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 657310000798 Synaptic Flat tetramer interface [polypeptide binding]; other site 657310000799 Synaptic Site I dimer interface [polypeptide binding]; other site 657310000800 DNA binding site [nucleotide binding] 657310000801 Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme; Region: NT_2-5OAS_ClassI-CCAase; cd05400 657310000802 active site 657310000803 NTP binding site [chemical binding]; other site 657310000804 metal binding triad [ion binding]; metal-binding site 657310000805 DNA topoisomerase III; Provisional; Region: PRK07726 657310000806 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 657310000807 active site 657310000808 putative interdomain interaction site [polypeptide binding]; other site 657310000809 putative metal-binding site [ion binding]; other site 657310000810 putative nucleotide binding site [chemical binding]; other site 657310000811 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 657310000812 domain I; other site 657310000813 DNA binding groove [nucleotide binding] 657310000814 phosphate binding site [ion binding]; other site 657310000815 domain II; other site 657310000816 domain III; other site 657310000817 nucleotide binding site [chemical binding]; other site 657310000818 catalytic site [active] 657310000819 domain IV; other site 657310000820 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 657310000821 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 657310000822 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 657310000823 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 657310000824 P-loop; other site 657310000825 Magnesium ion binding site [ion binding]; other site 657310000826 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 657310000827 Magnesium ion binding site [ion binding]; other site 657310000828 Bacterial epsilon antitoxin; Region: Epsilon_antitox; pfam08998 657310000829 Zeta toxin; Region: Zeta_toxin; pfam06414 657310000830 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185 657310000831 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG3392 657310000832 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 657310000833 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 657310000834 AlwI restriction endonuclease; Region: RE_AlwI; pfam09491 657310000835 Zeta toxin; Region: Zeta_toxin; pfam06414 657310000836 Phage terminase, small subunit; Region: Terminase_4; cl01525 657310000837 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cl00338 657310000838 Uncharacterized homolog of PrgY (pheromone shutdown protein) [Function unknown]; Region: COG1916 657310000839 SEC10/PgrA surface exclusion domain; Region: Surf_Exclu_PgrA; TIGR04320 657310000840 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 657310000841 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 657310000842 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 657310000843 Glucan-binding protein C; Region: GbpC; pfam08363 657310000844 adhesin isopeptide-forming domain, sspB-C2 type; Region: isopep_sspB_C2; TIGR04228 657310000845 adhesin isopeptide-forming domain, sspB-C2 type; Region: isopep_sspB_C2; TIGR04228 657310000846 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 657310000847 PrgU-like protein; Region: PrgU; pfam09627 657310000848 Protein of unknown function (DUF1761); Region: DUF1761; pfam08570 657310000849 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 657310000850 CHAP domain; Region: CHAP; cl17642 657310000851 integrating conjugative element protein, PFL_4705 family; Region: conj_TIGR03752 657310000852 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 657310000853 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 657310000854 Protein of unknown function (DUF3991); Region: DUF3991; pfam13154 657310000855 Toprim-like; Region: Toprim_2; pfam13155 657310000856 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 657310000857 S-adenosylmethionine binding site [chemical binding]; other site 657310000858 DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646 657310000859 DEAD-like helicases superfamily; Region: DEXDc; smart00487 657310000860 DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646 657310000861 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 657310000862 nucleotide binding region [chemical binding]; other site 657310000863 ATP-binding site [chemical binding]; other site 657310000864 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 657310000865 catalytic residues [active] 657310000866 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 657310000867 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 657310000868 dimer interface [polypeptide binding]; other site 657310000869 ssDNA binding site [nucleotide binding]; other site 657310000870 tetramer (dimer of dimers) interface [polypeptide binding]; other site 657310000871 Glucosyl transferase GtrII; Region: Glucos_trans_II; pfam14264 657310000872 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 657310000873 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 657310000874 catalytic residues [active] 657310000875 catalytic nucleophile [active] 657310000876 Presynaptic Site I dimer interface [polypeptide binding]; other site 657310000877 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 657310000878 Synaptic Flat tetramer interface [polypeptide binding]; other site 657310000879 Synaptic Site I dimer interface [polypeptide binding]; other site 657310000880 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 657310000881 DNA-binding interface [nucleotide binding]; DNA binding site 657310000882 Replication initiator protein A (RepA) N-terminus; Region: RepA_N; pfam06970 657310000883 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 657310000884 The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators; Region: NR_LBD; cl11397 657310000885 ligand binding site [chemical binding]; other site 657310000886 coregulator recognition site; other site 657310000887 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 657310000888 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 657310000889 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 657310000890 Phage capsid family; Region: Phage_capsid; pfam05065 657310000891 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 657310000892 oligomer interface [polypeptide binding]; other site 657310000893 active site residues [active] 657310000894 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 657310000895 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 657310000896 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 657310000897 active site 657310000898 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 657310000899 Domain of Unknown Function with PDB structure (DUF3850); Region: DUF3850; pfam12961 657310000900 Protein of unknown function (DUF1642); Region: DUF1642; pfam07852 657310000901 Restriction alleviation protein Lar; Region: Lar_restr_allev; pfam14354 657310000902 YopX protein; Region: YopX; pfam09643 657310000903 Protein of unknown function (DUF1064); Region: DUF1064; pfam06356 657310000904 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 657310000905 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 657310000906 Walker A motif; other site 657310000907 ATP binding site [chemical binding]; other site 657310000908 Walker B motif; other site 657310000909 PDDEXK-like domain of unknown function (DUF3799); Region: DUF3799; pfam12684 657310000910 RecT family; Region: RecT; pfam03837 657310000911 Domain of unknown function (DUF771); Region: DUF771; cl09962 657310000912 phage-associated protein, BcepMu gp16 family; Region: BcepMu_gp16; TIGR04111 657310000913 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 657310000914 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 657310000915 non-specific DNA binding site [nucleotide binding]; other site 657310000916 salt bridge; other site 657310000917 sequence-specific DNA binding site [nucleotide binding]; other site 657310000918 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 657310000919 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 657310000920 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 657310000921 Cna protein B-type domain; Region: Cna_B; pfam05738 657310000922 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 657310000923 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 657310000924 metal ion-dependent adhesion site (MIDAS); other site 657310000925 Cna protein B-type domain; Region: Cna_B; pfam05738 657310000926 Cna protein B-type domain; Region: Cna_B; pfam05738 657310000927 Mga helix-turn-helix domain; Region: Mga; pfam05043 657310000928 Protein of unknown function (DUF805); Region: DUF805; pfam05656 657310000929 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 657310000930 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 657310000931 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 657310000932 Coenzyme A binding pocket [chemical binding]; other site 657310000933 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 657310000934 Ligand Binding Site [chemical binding]; other site 657310000935 Protein of unknown function (DUF3016); Region: DUF3016; pfam11454 657310000936 DNA polymerase IV; Reviewed; Region: PRK03103 657310000937 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 657310000938 active site 657310000939 DNA binding site [nucleotide binding] 657310000940 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 657310000941 putative substrate translocation pore; other site 657310000942 Major Facilitator Superfamily; Region: MFS_1; pfam07690 657310000943 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 657310000944 Coenzyme A binding pocket [chemical binding]; other site 657310000945 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 657310000946 hypothetical protein; Provisional; Region: PRK06762 657310000947 AAA domain; Region: AAA_33; pfam13671 657310000948 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 657310000949 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 657310000950 Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744 657310000951 maltose O-acetyltransferase; Provisional; Region: PRK10092 657310000952 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 657310000953 active site 657310000954 substrate binding site [chemical binding]; other site 657310000955 trimer interface [polypeptide binding]; other site 657310000956 CoA binding site [chemical binding]; other site 657310000957 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 657310000958 putative deaminase; Validated; Region: PRK06846 657310000959 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 657310000960 active site 657310000961 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 657310000962 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 657310000963 peptide binding site [polypeptide binding]; other site 657310000964 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 657310000965 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 657310000966 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 657310000967 Ligand Binding Site [chemical binding]; other site 657310000968 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 657310000969 AAA domain; Region: AAA_18; pfam13238 657310000970 active site 657310000971 Bacterial protein of unknown function (DUF898); Region: DUF898; cl01738 657310000972 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 657310000973 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 657310000974 Walker A/P-loop; other site 657310000975 ATP binding site [chemical binding]; other site 657310000976 Q-loop/lid; other site 657310000977 ABC transporter signature motif; other site 657310000978 Walker B; other site 657310000979 D-loop; other site 657310000980 H-loop/switch region; other site 657310000981 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 657310000982 S-adenosylmethionine binding site [chemical binding]; other site 657310000983 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 657310000984 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 657310000985 Uncharacterized conserved protein [Function unknown]; Region: COG1556 657310000986 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 657310000987 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 657310000988 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 657310000989 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 657310000990 Part of AAA domain; Region: AAA_19; pfam13245 657310000991 Family description; Region: UvrD_C_2; pfam13538 657310000992 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 657310000993 Predicted transcriptional regulators [Transcription]; Region: COG1733 657310000994 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 657310000995 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 657310000996 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 657310000997 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 657310000998 dimer interface [polypeptide binding]; other site 657310000999 motif 1; other site 657310001000 active site 657310001001 motif 2; other site 657310001002 motif 3; other site 657310001003 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 657310001004 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 657310001005 putative tRNA-binding site [nucleotide binding]; other site 657310001006 B3/4 domain; Region: B3_4; pfam03483 657310001007 tRNA synthetase B5 domain; Region: B5; smart00874 657310001008 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 657310001009 dimer interface [polypeptide binding]; other site 657310001010 motif 1; other site 657310001011 motif 3; other site 657310001012 motif 2; other site 657310001013 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 657310001014 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 657310001015 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 657310001016 dimer interface [polypeptide binding]; other site 657310001017 conserved gate region; other site 657310001018 putative PBP binding loops; other site 657310001019 ABC-ATPase subunit interface; other site 657310001020 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 657310001021 dimer interface [polypeptide binding]; other site 657310001022 conserved gate region; other site 657310001023 putative PBP binding loops; other site 657310001024 ABC-ATPase subunit interface; other site 657310001025 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 657310001026 substrate binding pocket [chemical binding]; other site 657310001027 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 657310001028 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 657310001029 Walker A/P-loop; other site 657310001030 ATP binding site [chemical binding]; other site 657310001031 Q-loop/lid; other site 657310001032 ABC transporter signature motif; other site 657310001033 Walker B; other site 657310001034 D-loop; other site 657310001035 H-loop/switch region; other site 657310001036 glutamate racemase; Provisional; Region: PRK00865 657310001037 Predicted phosphoesterases, related to the Icc protein [General function prediction only]; Region: COG2129 657310001038 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 657310001039 active site 657310001040 metal binding site [ion binding]; metal-binding site 657310001041 homotetramer interface [polypeptide binding]; other site 657310001042 putative L-ascorbate 6-phosphate lactonase; Provisional; Region: PRK11709 657310001043 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 657310001044 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 657310001045 active site 657310001046 phosphorylation site [posttranslational modification] 657310001047 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: PRK12997 657310001048 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 657310001049 active site 657310001050 P-loop; other site 657310001051 phosphorylation site [posttranslational modification] 657310001052 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 657310001053 active site 657310001054 dimer interface [polypeptide binding]; other site 657310001055 magnesium binding site [ion binding]; other site 657310001056 putative L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13210 657310001057 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 657310001058 AP (apurinic/apyrimidinic) site pocket; other site 657310001059 DNA interaction; other site 657310001060 Metal-binding active site; metal-binding site 657310001061 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 657310001062 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 657310001063 intersubunit interface [polypeptide binding]; other site 657310001064 active site 657310001065 Zn2+ binding site [ion binding]; other site 657310001066 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 657310001067 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 657310001068 M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670 657310001069 metal binding site [ion binding]; metal-binding site 657310001070 putative dimer interface [polypeptide binding]; other site 657310001071 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 657310001072 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 657310001073 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 657310001074 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 657310001075 dimer interface [polypeptide binding]; other site 657310001076 active site 657310001077 metal binding site [ion binding]; metal-binding site 657310001078 glutathione binding site [chemical binding]; other site 657310001079 Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684 657310001080 nudix motif; other site 657310001081 sugar phosphate phosphatase; Provisional; Region: PRK10513 657310001082 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 657310001083 active site 657310001084 motif I; other site 657310001085 motif II; other site 657310001086 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 657310001087 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 657310001088 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 657310001089 Zn2+ binding site [ion binding]; other site 657310001090 Mg2+ binding site [ion binding]; other site 657310001091 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 657310001092 Domain of unknown function (DUF1934); Region: DUF1934; pfam09148 657310001093 CTP synthetase; Validated; Region: pyrG; PRK05380 657310001094 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 657310001095 Catalytic site [active] 657310001096 active site 657310001097 UTP binding site [chemical binding]; other site 657310001098 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 657310001099 active site 657310001100 putative oxyanion hole; other site 657310001101 catalytic triad [active] 657310001102 Transglycosylase; Region: Transgly; pfam00912 657310001103 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 657310001104 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 657310001105 hypothetical protein; Provisional; Region: PRK13660 657310001106 cell division protein GpsB; Provisional; Region: PRK14127 657310001107 DivIVA domain; Region: DivI1A_domain; TIGR03544 657310001108 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 657310001109 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 657310001110 active site 657310001111 Zn binding site [ion binding]; other site 657310001112 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 657310001113 Helix-turn-helix domain; Region: HTH_36; pfam13730 657310001114 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 657310001115 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 657310001116 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 657310001117 minor groove reading motif; other site 657310001118 helix-hairpin-helix signature motif; other site 657310001119 substrate binding pocket [chemical binding]; other site 657310001120 active site 657310001121 Glycosylasparaginase catalyzes the hydrolysis of the glycosylamide bond of asparagine-linked glycoproteins. This enzyme is an amidase located inside lysosomes. Mutation of this gene in humans causes a genetic disorder known as aspartylglycosaminuria (AGU)...; Region: Glycosylasparaginase; cd04513 657310001122 active site 657310001123 dimer interface [polypeptide binding]; other site 657310001124 catalytic nucleophile [active] 657310001125 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 657310001126 active site 657310001127 P-loop; other site 657310001128 phosphorylation site [posttranslational modification] 657310001129 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 657310001130 active site 657310001131 homotetramer interface [polypeptide binding]; other site 657310001132 homodimer interface [polypeptide binding]; other site 657310001133 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 657310001134 Zn2+ binding site [ion binding]; other site 657310001135 Mg2+ binding site [ion binding]; other site 657310001136 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 657310001137 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 657310001138 Uncharacterized conserved protein [Function unknown]; Region: COG1284 657310001139 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 657310001140 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 657310001141 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 657310001142 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 657310001143 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 657310001144 intersubunit interface [polypeptide binding]; other site 657310001145 active site 657310001146 zinc binding site [ion binding]; other site 657310001147 Na+ binding site [ion binding]; other site 657310001148 transcription termination factor Rho; Provisional; Region: rho; PRK09376 657310001149 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 657310001150 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 657310001151 RNA binding site [nucleotide binding]; other site 657310001152 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 657310001153 multimer interface [polypeptide binding]; other site 657310001154 Walker A motif; other site 657310001155 ATP binding site [chemical binding]; other site 657310001156 Walker B motif; other site 657310001157 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 657310001158 glycerol-3-phosphate cytidylyltransferase; Region: g3p_cytidyltrns; TIGR01518 657310001159 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 657310001160 active site 657310001161 nucleotide binding site [chemical binding]; other site 657310001162 HIGH motif; other site 657310001163 KMSKS motif; other site 657310001164 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 657310001165 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 657310001166 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 657310001167 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 657310001168 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 657310001169 nucleotide binding site [chemical binding]; other site 657310001170 CsbD-like; Region: CsbD; cl17424 657310001171 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 657310001172 dimer interface [polypeptide binding]; other site 657310001173 FMN binding site [chemical binding]; other site 657310001174 NADPH bind site [chemical binding]; other site 657310001175 S-ribosylhomocysteinase; Provisional; Region: PRK02260 657310001176 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 657310001177 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 657310001178 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 657310001179 dihydrodipicolinate synthase; Region: dapA; TIGR00674 657310001180 dimer interface [polypeptide binding]; other site 657310001181 active site 657310001182 catalytic residue [active] 657310001183 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 657310001184 EDD domain protein, DegV family; Region: DegV; TIGR00762 657310001185 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 657310001186 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 657310001187 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 657310001188 dimerization interface [polypeptide binding]; other site 657310001189 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 657310001190 putative active site [active] 657310001191 heme pocket [chemical binding]; other site 657310001192 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 657310001193 dimer interface [polypeptide binding]; other site 657310001194 phosphorylation site [posttranslational modification] 657310001195 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 657310001196 ATP binding site [chemical binding]; other site 657310001197 Mg2+ binding site [ion binding]; other site 657310001198 G-X-G motif; other site 657310001199 YycH protein; Region: YycH; pfam07435 657310001200 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863 657310001201 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 657310001202 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 657310001203 Predicted permeases [General function prediction only]; Region: COG0701 657310001204 Domain of unknown function (DUF1980); Region: DUF1980; cl01492 657310001205 Uncharacterized conserved protein [Function unknown]; Region: COG2966 657310001206 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 657310001207 hypothetical protein; Provisional; Region: PRK05473 657310001208 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 657310001209 hypothetical protein; Provisional; Region: PRK13678 657310001210 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 657310001211 2-hydroxycarboxylate transporter family; Region: 2HCT; pfam03390 657310001212 PAS domain S-box; Region: sensory_box; TIGR00229 657310001213 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 657310001214 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 657310001215 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 657310001216 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 657310001217 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 657310001218 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306 657310001219 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 657310001220 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 657310001221 dimer interface [polypeptide binding]; other site 657310001222 conserved gate region; other site 657310001223 putative PBP binding loops; other site 657310001224 ABC-ATPase subunit interface; other site 657310001225 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 657310001226 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 657310001227 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 657310001228 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 657310001229 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 657310001230 active site 657310001231 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 657310001232 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 657310001233 N-ethylammeline chlorohydrolase; Provisional; Region: PRK09045 657310001234 active site 657310001235 putative substrate binding pocket [chemical binding]; other site 657310001236 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 657310001237 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 657310001238 non-specific DNA binding site [nucleotide binding]; other site 657310001239 salt bridge; other site 657310001240 sequence-specific DNA binding site [nucleotide binding]; other site 657310001241 Predicted flavoprotein [General function prediction only]; Region: COG0431 657310001242 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 657310001243 Predicted flavoprotein [General function prediction only]; Region: COG0431 657310001244 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 657310001245 PAS domain; Region: PAS_10; pfam13596 657310001246 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 657310001247 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 657310001248 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 657310001249 dimer interface [polypeptide binding]; other site 657310001250 conserved gate region; other site 657310001251 ABC-ATPase subunit interface; other site 657310001252 Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448 657310001253 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 657310001254 Exonuclease-Endonuclease-Phosphatase domain; uncharacterized family 1; Region: EEP-1; cd09083 657310001255 putative catalytic site [active] 657310001256 putative metal binding site [ion binding]; other site 657310001257 putative phosphate binding site [ion binding]; other site 657310001258 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 657310001259 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 657310001260 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 657310001261 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 657310001262 Transcriptional regulators [Transcription]; Region: PurR; COG1609 657310001263 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 657310001264 DNA binding site [nucleotide binding] 657310001265 domain linker motif; other site 657310001266 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 657310001267 dimerization interface [polypeptide binding]; other site 657310001268 ligand binding site [chemical binding]; other site 657310001269 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 657310001270 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 657310001271 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 657310001272 DNA-binding site [nucleotide binding]; DNA binding site 657310001273 UTRA domain; Region: UTRA; pfam07702 657310001274 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 657310001275 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 657310001276 putative oxidoreductase; Provisional; Region: PRK10206 657310001277 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 657310001278 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 657310001279 glycoprotein BALF4; Provisional; Region: PHA03231 657310001280 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 657310001281 Domain of unknown function (DUF814); Region: DUF814; pfam05670 657310001282 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 657310001283 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 657310001284 zinc binding site [ion binding]; other site 657310001285 putative ligand binding site [chemical binding]; other site 657310001286 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 657310001287 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 657310001288 TM-ABC transporter signature motif; other site 657310001289 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 657310001290 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 657310001291 Walker A/P-loop; other site 657310001292 ATP binding site [chemical binding]; other site 657310001293 Q-loop/lid; other site 657310001294 ABC transporter signature motif; other site 657310001295 Walker B; other site 657310001296 D-loop; other site 657310001297 H-loop/switch region; other site 657310001298 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 657310001299 Uncharacterized conserved protein [Function unknown]; Region: COG2966 657310001300 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 657310001301 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 657310001302 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 657310001303 active site 657310001304 motif I; other site 657310001305 motif II; other site 657310001306 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 657310001307 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 657310001308 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 657310001309 active site 657310001310 phosphorylation site [posttranslational modification] 657310001311 intermolecular recognition site; other site 657310001312 dimerization interface [polypeptide binding]; other site 657310001313 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 657310001314 DNA binding site [nucleotide binding] 657310001315 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 657310001316 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 657310001317 dimerization interface [polypeptide binding]; other site 657310001318 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 657310001319 dimer interface [polypeptide binding]; other site 657310001320 phosphorylation site [posttranslational modification] 657310001321 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 657310001322 ATP binding site [chemical binding]; other site 657310001323 G-X-G motif; other site 657310001324 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 657310001325 Q-loop/lid; other site 657310001326 ABC transporter signature motif; other site 657310001327 Walker B; other site 657310001328 D-loop; other site 657310001329 H-loop/switch region; other site 657310001330 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 657310001331 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 657310001332 putative RNA binding site [nucleotide binding]; other site 657310001333 ribonuclease HIII; Provisional; Region: PRK00996 657310001334 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 657310001335 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 657310001336 RNA/DNA hybrid binding site [nucleotide binding]; other site 657310001337 active site 657310001338 Collagen binding domain; Region: Collagen_bind; pfam05737 657310001339 Cna protein B-type domain; Region: Cna_B; pfam05738 657310001340 streptococcal pilin isopeptide linkage domain; Region: strep_pil_rpt; TIGR03786 657310001341 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 657310001342 NusA N-terminal domain; Region: NusA_N; pfam08529 657310001343 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 657310001344 RNA binding site [nucleotide binding]; other site 657310001345 homodimer interface [polypeptide binding]; other site 657310001346 NusA-like KH domain; Region: KH_5; pfam13184 657310001347 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 657310001348 G-X-X-G motif; other site 657310001349 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 657310001350 putative RNA binding cleft [nucleotide binding]; other site 657310001351 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 657310001352 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 657310001353 translation initiation factor IF-2; Region: IF-2; TIGR00487 657310001354 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 657310001355 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 657310001356 G1 box; other site 657310001357 putative GEF interaction site [polypeptide binding]; other site 657310001358 GTP/Mg2+ binding site [chemical binding]; other site 657310001359 Switch I region; other site 657310001360 G2 box; other site 657310001361 G3 box; other site 657310001362 Switch II region; other site 657310001363 G4 box; other site 657310001364 G5 box; other site 657310001365 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 657310001366 Translation-initiation factor 2; Region: IF-2; pfam11987 657310001367 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 657310001368 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 657310001369 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 657310001370 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 657310001371 non-specific DNA binding site [nucleotide binding]; other site 657310001372 salt bridge; other site 657310001373 sequence-specific DNA binding site [nucleotide binding]; other site 657310001374 DnaD and phage-associated domain; Region: DnaD_dom; TIGR01446 657310001375 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 657310001376 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 657310001377 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 657310001378 Walker A motif; other site 657310001379 Walker A motif; other site 657310001380 ATP binding site [chemical binding]; other site 657310001381 ATP binding site [chemical binding]; other site 657310001382 Walker B motif; other site 657310001383 phage transcriptional activator, RinA family; Region: phage_rinA; TIGR01636 657310001384 Phage major tail protein 2; Region: Phage_tail_2; cl11463 657310001385 Phage protein; Region: DUF3647; pfam12363 657310001386 Phage-related protein [Function unknown]; Region: COG5412 657310001387 Phage tail protein; Region: Sipho_tail; pfam05709 657310001388 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 657310001389 Holin family; Region: Phage_holin_4; pfam05105 657310001390 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01550 657310001391 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 657310001392 RNA binding site [nucleotide binding]; other site 657310001393 active site 657310001394 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 657310001395 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 657310001396 active site 657310001397 Riboflavin kinase; Region: Flavokinase; smart00904 657310001398 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 657310001399 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 657310001400 Coenzyme A binding pocket [chemical binding]; other site 657310001401 Protein of unknown function (DUF1048); Region: DUF1048; pfam06304 657310001402 Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; pfam09860 657310001403 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 657310001404 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 657310001405 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 657310001406 Transcriptional regulator [Transcription]; Region: LysR; COG0583 657310001407 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 657310001408 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 657310001409 dimerization interface [polypeptide binding]; other site 657310001410 Transcriptional regulator [Transcription]; Region: LysR; COG0583 657310001411 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 657310001412 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 657310001413 dimerization interface [polypeptide binding]; other site 657310001414 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 657310001415 magnesium-transporting ATPase; Provisional; Region: PRK15122 657310001416 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 657310001417 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 657310001418 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 657310001419 motif II; other site 657310001420 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 657310001421 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 657310001422 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 657310001423 FeS/SAM binding site; other site 657310001424 HemN C-terminal domain; Region: HemN_C; pfam06969 657310001425 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 657310001426 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 657310001427 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 657310001428 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 657310001429 nucleotide binding site [chemical binding]; other site 657310001430 NEF interaction site [polypeptide binding]; other site 657310001431 SBD interface [polypeptide binding]; other site 657310001432 chaperone protein DnaJ; Provisional; Region: PRK14276 657310001433 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 657310001434 HSP70 interaction site [polypeptide binding]; other site 657310001435 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 657310001436 substrate binding site [polypeptide binding]; other site 657310001437 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 657310001438 Zn binding sites [ion binding]; other site 657310001439 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 657310001440 substrate binding site [polypeptide binding]; other site 657310001441 dimer interface [polypeptide binding]; other site 657310001442 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 657310001443 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 657310001444 active site 657310001445 metal binding site [ion binding]; metal-binding site 657310001446 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 657310001447 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 657310001448 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 657310001449 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 657310001450 RNA binding site [nucleotide binding]; other site 657310001451 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 657310001452 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 657310001453 non-specific DNA binding site [nucleotide binding]; other site 657310001454 salt bridge; other site 657310001455 sequence-specific DNA binding site [nucleotide binding]; other site 657310001456 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 657310001457 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 657310001458 active site 657310001459 dimer interface [polypeptide binding]; other site 657310001460 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; pfam13930 657310001461 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 657310001462 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 657310001463 FtsX-like permease family; Region: FtsX; pfam02687 657310001464 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 657310001465 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 657310001466 FtsX-like permease family; Region: FtsX; pfam02687 657310001467 Protein of unknown function (DUF2969); Region: DUF2969; pfam11184 657310001468 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 657310001469 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 657310001470 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 657310001471 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 657310001472 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 657310001473 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 657310001474 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3580 657310001475 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 657310001476 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 657310001477 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 657310001478 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 657310001479 DNA-binding site [nucleotide binding]; DNA binding site 657310001480 UTRA domain; Region: UTRA; pfam07702 657310001481 ThiF family; Region: ThiF; pfam00899 657310001482 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 [Coenzyme metabolism]; Region: ThiF; COG0476 657310001483 ATP binding site [chemical binding]; other site 657310001484 substrate interface [chemical binding]; other site 657310001485 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 657310001486 Walker A/P-loop; other site 657310001487 ATP binding site [chemical binding]; other site 657310001488 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 657310001489 ABC transporter signature motif; other site 657310001490 Walker B; other site 657310001491 D-loop; other site 657310001492 H-loop/switch region; other site 657310001493 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 657310001494 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 657310001495 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 657310001496 Walker A/P-loop; other site 657310001497 ATP binding site [chemical binding]; other site 657310001498 Q-loop/lid; other site 657310001499 ABC transporter signature motif; other site 657310001500 Walker B; other site 657310001501 D-loop; other site 657310001502 H-loop/switch region; other site 657310001503 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 657310001504 FtsX-like permease family; Region: FtsX; pfam02687 657310001505 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 657310001506 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 657310001507 dimer interface [polypeptide binding]; other site 657310001508 conserved gate region; other site 657310001509 putative PBP binding loops; other site 657310001510 ABC-ATPase subunit interface; other site 657310001511 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 657310001512 dimer interface [polypeptide binding]; other site 657310001513 conserved gate region; other site 657310001514 ABC-ATPase subunit interface; other site 657310001515 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 657310001516 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 657310001517 homodimer interface [polypeptide binding]; other site 657310001518 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 657310001519 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 657310001520 active site 657310001521 homodimer interface [polypeptide binding]; other site 657310001522 catalytic site [active] 657310001523 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 657310001524 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 657310001525 Ca binding site [ion binding]; other site 657310001526 active site 657310001527 catalytic site [active] 657310001528 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 657310001529 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 657310001530 Ca binding site [ion binding]; other site 657310001531 active site 657310001532 catalytic site [active] 657310001533 Protein of unknown function (DUF1211); Region: DUF1211; cl01421 657310001534 magnesium-transporting ATPase; Provisional; Region: PRK15122 657310001535 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 657310001536 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 657310001537 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 657310001538 Soluble P-type ATPase [General function prediction only]; Region: COG4087 657310001539 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 657310001540 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 657310001541 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 657310001542 alpha subunit interface [polypeptide binding]; other site 657310001543 TPP binding site [chemical binding]; other site 657310001544 heterodimer interface [polypeptide binding]; other site 657310001545 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 657310001546 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 657310001547 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 657310001548 E3 interaction surface; other site 657310001549 lipoyl attachment site [posttranslational modification]; other site 657310001550 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 657310001551 E3 interaction surface; other site 657310001552 lipoyl attachment site [posttranslational modification]; other site 657310001553 e3 binding domain; Region: E3_binding; pfam02817 657310001554 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 657310001555 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 657310001556 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 657310001557 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 657310001558 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 657310001559 Sensory domain found in PocR; Region: PocR; pfam10114 657310001560 Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936 657310001561 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 657310001562 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 657310001563 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 657310001564 dihydroxyacetone kinase, phosphotransfer subunit; Region: dha_pts; TIGR02364 657310001565 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 657310001566 dihydroxyacetone kinase, phosphoprotein-dependent, L subunit; Region: dha_L_ycgS; TIGR02365 657310001567 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 657310001568 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835 657310001569 dimer interface [polypeptide binding]; other site 657310001570 active site 657310001571 Domain of unknown function DUF20; Region: UPF0118; pfam01594 657310001572 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 657310001573 Uncharacterized conserved protein [Function unknown]; Region: COG1434 657310001574 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 657310001575 putative active site [active] 657310001576 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 657310001577 DNA-binding site [nucleotide binding]; DNA binding site 657310001578 RNA-binding motif; other site 657310001579 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 657310001580 Major Facilitator Superfamily; Region: MFS_1; pfam07690 657310001581 putative substrate translocation pore; other site 657310001582 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 657310001583 metal-dependent hydrolase; Provisional; Region: PRK00685 657310001584 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 657310001585 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 657310001586 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 657310001587 DNA-binding site [nucleotide binding]; DNA binding site 657310001588 DRTGG domain; Region: DRTGG; pfam07085 657310001589 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 657310001590 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 657310001591 active site 2 [active] 657310001592 active site 1 [active] 657310001593 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 657310001594 DHH family; Region: DHH; pfam01368 657310001595 DHHA1 domain; Region: DHHA1; pfam02272 657310001596 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 657310001597 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 657310001598 PhnA protein; Region: PhnA; pfam03831 657310001599 VanZ like family; Region: VanZ; cl01971 657310001600 RDD family; Region: RDD; pfam06271 657310001601 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 657310001602 DNA binding site [nucleotide binding] 657310001603 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 657310001604 Family of unknown function (DUF633); Region: DUF633; pfam04816 657310001605 Uncharacterized conserved protein [Function unknown]; Region: COG0327 657310001606 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 657310001607 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 657310001608 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 657310001609 Uncharacterized conserved protein [Function unknown]; Region: COG0327 657310001610 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 657310001611 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 657310001612 metal binding site [ion binding]; metal-binding site 657310001613 dimer interface [polypeptide binding]; other site 657310001614 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 657310001615 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 657310001616 GTP binding site; other site 657310001617 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 657310001618 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 657310001619 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 657310001620 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 657310001621 [2Fe-2S] cluster binding site [ion binding]; other site 657310001622 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 657310001623 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 657310001624 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 657310001625 catalytic loop [active] 657310001626 iron binding site [ion binding]; other site 657310001627 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 657310001628 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 657310001629 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 657310001630 molybdopterin cofactor binding site; other site 657310001631 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 657310001632 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790 657310001633 molybdopterin cofactor binding site; other site 657310001634 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 657310001635 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 657310001636 dimer interface [polypeptide binding]; other site 657310001637 putative functional site; other site 657310001638 putative MPT binding site; other site 657310001639 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 657310001640 trimer interface [polypeptide binding]; other site 657310001641 dimer interface [polypeptide binding]; other site 657310001642 putative active site [active] 657310001643 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 657310001644 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 657310001645 FeS/SAM binding site; other site 657310001646 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 657310001647 MOSC domain; Region: MOSC; pfam03473 657310001648 MoeA_like. This domain is similar to a domain found in a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. There this domain is presumed to bind molybdopterin. The exact function of this subgroup is...; Region: MoeA_like; cd03522 657310001649 putative MPT binding site; other site 657310001650 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 657310001651 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 657310001652 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 657310001653 putative PBP binding loops; other site 657310001654 ABC-ATPase subunit interface; other site 657310001655 ATP-binding cassette domain of the molybdenum transport system; Region: ABC_ModC_molybdenum_transporter; cd03297 657310001656 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 657310001657 Walker A/P-loop; other site 657310001658 ATP binding site [chemical binding]; other site 657310001659 Q-loop/lid; other site 657310001660 ABC transporter signature motif; other site 657310001661 Walker B; other site 657310001662 D-loop; other site 657310001663 H-loop/switch region; other site 657310001664 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 657310001665 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 657310001666 metal-binding site [ion binding] 657310001667 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 657310001668 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 657310001669 Cell division protein ZapA; Region: ZapA; cl01146 657310001670 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 657310001671 Colicin V production protein; Region: Colicin_V; pfam02674 657310001672 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 657310001673 MutS domain III; Region: MutS_III; pfam05192 657310001674 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 657310001675 Walker A/P-loop; other site 657310001676 ATP binding site [chemical binding]; other site 657310001677 Q-loop/lid; other site 657310001678 ABC transporter signature motif; other site 657310001679 Walker B; other site 657310001680 D-loop; other site 657310001681 H-loop/switch region; other site 657310001682 Smr domain; Region: Smr; pfam01713 657310001683 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 657310001684 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 657310001685 catalytic residues [active] 657310001686 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 657310001687 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 657310001688 GIY-YIG motif/motif A; other site 657310001689 active site 657310001690 catalytic site [active] 657310001691 putative DNA binding site [nucleotide binding]; other site 657310001692 metal binding site [ion binding]; metal-binding site 657310001693 UvrB/uvrC motif; Region: UVR; pfam02151 657310001694 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 657310001695 Protein of unknown function (DUF3884); Region: DUF3884; pfam13024 657310001696 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 657310001697 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 657310001698 substrate binding site [chemical binding]; other site 657310001699 HI0933-like protein; Region: HI0933_like; pfam03486 657310001700 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 657310001701 NAD(P) binding pocket [chemical binding]; other site 657310001702 flavoprotein NrdI; Provisional; Region: PRK02551 657310001703 V-type ATP synthase subunit I; Validated; Region: PRK05771 657310001704 V-type ATP synthase subunit K; Validated; Region: PRK06558 657310001705 ATP synthase subunit C; Region: ATP-synt_C; pfam00137 657310001706 ATP synthase subunit C; Region: ATP-synt_C; pfam00137 657310001707 phosphodiesterase; Provisional; Region: PRK12704 657310001708 V-type ATP synthase subunit C; Provisional; Region: PRK01198; cl00660 657310001709 V-type ATP synthase subunit F; Provisional; Region: PRK01395 657310001710 V-type ATP synthase subunit B; Provisional; Region: PRK04196 657310001711 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 657310001712 V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_B; cd01135 657310001713 Walker A motif homologous position; other site 657310001714 Walker B motif; other site 657310001715 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 657310001716 V-type ATP synthase subunit D; Reviewed; Region: PRK00373 657310001717 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 657310001718 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 657310001719 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 657310001720 DNA binding residues [nucleotide binding] 657310001721 diaminopimelate decarboxylase; Region: lysA; TIGR01048 657310001722 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 657310001723 active site 657310001724 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 657310001725 substrate binding site [chemical binding]; other site 657310001726 catalytic residues [active] 657310001727 dimer interface [polypeptide binding]; other site 657310001728 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 657310001729 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 657310001730 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 657310001731 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 657310001732 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 657310001733 active site 657310001734 transcriptional antiterminator BglG; Provisional; Region: PRK09772 657310001735 CAT RNA binding domain; Region: CAT_RBD; smart01061 657310001736 PRD domain; Region: PRD; pfam00874 657310001737 PRD domain; Region: PRD; pfam00874 657310001738 PTS system arbutin-specific transporter subunit IIB; Provisional; Region: PRK09702 657310001739 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 657310001740 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 657310001741 active site turn [active] 657310001742 phosphorylation site [posttranslational modification] 657310001743 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 657310001744 HPr interaction site; other site 657310001745 glycerol kinase (GK) interaction site [polypeptide binding]; other site 657310001746 active site 657310001747 phosphorylation site [posttranslational modification] 657310001748 HTH domain; Region: HTH_11; pfam08279 657310001749 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 657310001750 active site 657310001751 phosphorylation site [posttranslational modification] 657310001752 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 657310001753 active site 657310001754 P-loop; other site 657310001755 phosphorylation site [posttranslational modification] 657310001756 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 657310001757 active site 657310001758 phosphorylation site [posttranslational modification] 657310001759 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 657310001760 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 657310001761 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 657310001762 substrate binding site [chemical binding]; other site 657310001763 hexamer interface [polypeptide binding]; other site 657310001764 metal binding site [ion binding]; metal-binding site 657310001765 Lysozyme-like; Region: Lysozyme_like; pfam13702 657310001766 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 657310001767 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 657310001768 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 657310001769 motif II; other site 657310001770 DNA primase, catalytic core; Region: dnaG; TIGR01391 657310001771 CHC2 zinc finger; Region: zf-CHC2; pfam01807 657310001772 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 657310001773 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 657310001774 active site 657310001775 metal binding site [ion binding]; metal-binding site 657310001776 interdomain interaction site; other site 657310001777 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 657310001778 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 657310001779 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 657310001780 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 657310001781 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 657310001782 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 657310001783 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 657310001784 DNA binding residues [nucleotide binding] 657310001785 ATP-dependent nuclease subunit B; Region: rexB_recomb; TIGR02774 657310001786 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 657310001787 S1 domain; Region: S1_2; pfam13509 657310001788 ferric uptake regulator; Provisional; Region: fur; PRK09462 657310001789 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 657310001790 metal binding site 2 [ion binding]; metal-binding site 657310001791 putative DNA binding helix; other site 657310001792 metal binding site 1 [ion binding]; metal-binding site 657310001793 dimer interface [polypeptide binding]; other site 657310001794 structural Zn2+ binding site [ion binding]; other site 657310001795 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 657310001796 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 657310001797 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 657310001798 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 657310001799 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 657310001800 WHG domain; Region: WHG; pfam13305 657310001801 Uncharacterized conserved protein [Function unknown]; Region: COG3589 657310001802 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 657310001803 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 657310001804 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 657310001805 active site 657310001806 Int/Topo IB signature motif; other site 657310001807 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 657310001808 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 657310001809 RNA binding surface [nucleotide binding]; other site 657310001810 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 657310001811 active site 657310001812 Predicted membrane protein [Function unknown]; Region: COG3601 657310001813 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 657310001814 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 657310001815 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 657310001816 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 657310001817 cytidylate kinase; Provisional; Region: cmk; PRK00023 657310001818 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 657310001819 CMP-binding site; other site 657310001820 The sites determining sugar specificity; other site 657310001821 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 657310001822 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 657310001823 RNA binding site [nucleotide binding]; other site 657310001824 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 657310001825 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 657310001826 RNA binding site [nucleotide binding]; other site 657310001827 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 657310001828 RNA binding site [nucleotide binding]; other site 657310001829 GTP-binding protein Der; Reviewed; Region: PRK00093 657310001830 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 657310001831 G1 box; other site 657310001832 GTP/Mg2+ binding site [chemical binding]; other site 657310001833 Switch I region; other site 657310001834 G2 box; other site 657310001835 Switch II region; other site 657310001836 G3 box; other site 657310001837 G4 box; other site 657310001838 G5 box; other site 657310001839 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 657310001840 G1 box; other site 657310001841 GTP/Mg2+ binding site [chemical binding]; other site 657310001842 Switch I region; other site 657310001843 G2 box; other site 657310001844 G3 box; other site 657310001845 Switch II region; other site 657310001846 G4 box; other site 657310001847 G5 box; other site 657310001848 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 657310001849 IHF dimer interface [polypeptide binding]; other site 657310001850 IHF - DNA interface [nucleotide binding]; other site 657310001851 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 657310001852 TPR motif; other site 657310001853 binding surface 657310001854 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 657310001855 binding surface 657310001856 TPR motif; other site 657310001857 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 657310001858 TPR motif; other site 657310001859 binding surface 657310001860 hypothetical protein; Provisional; Region: PRK03636 657310001861 UPF0302 domain; Region: UPF0302; pfam08864 657310001862 A short protein domain of unknown function; Region: IDEAL; smart00914 657310001863 Uncharacterized conserved protein [Function unknown]; Region: COG1284 657310001864 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 657310001865 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 657310001866 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531 657310001867 homodimer interface [polypeptide binding]; other site 657310001868 metal binding site [ion binding]; metal-binding site 657310001869 dihydrodipicolinate reductase; Provisional; Region: PRK00048 657310001870 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 657310001871 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 657310001872 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 657310001873 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 657310001874 active site 657310001875 NTP binding site [chemical binding]; other site 657310001876 metal binding triad [ion binding]; metal-binding site 657310001877 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 657310001878 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 657310001879 Predicted thioesterase [General function prediction only]; Region: COG5496 657310001880 shikimate 5-dehydrogenase; Provisional; Region: PRK12548 657310001881 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 657310001882 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 657310001883 shikimate binding site; other site 657310001884 NAD(P) binding site [chemical binding]; other site 657310001885 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 657310001886 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 657310001887 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 657310001888 active site 657310001889 dimer interface [polypeptide binding]; other site 657310001890 metal binding site [ion binding]; metal-binding site 657310001891 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 657310001892 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 657310001893 Tetramer interface [polypeptide binding]; other site 657310001894 active site 657310001895 FMN-binding site [chemical binding]; other site 657310001896 prephenate dehydrogenase; Validated; Region: PRK06545 657310001897 prephenate dehydrogenase; Validated; Region: PRK08507 657310001898 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 657310001899 shikimate kinase; Reviewed; Region: aroK; PRK00131 657310001900 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 657310001901 ADP binding site [chemical binding]; other site 657310001902 magnesium binding site [ion binding]; other site 657310001903 putative shikimate binding site; other site 657310001904 Prephenate dehydratase; Region: PDT; pfam00800 657310001905 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816 657310001906 EDD domain protein, DegV family; Region: DegV; TIGR00762 657310001907 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 657310001908 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 657310001909 thymidylate synthase; Region: thym_sym; TIGR03284 657310001910 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 657310001911 dimerization interface [polypeptide binding]; other site 657310001912 active site 657310001913 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 657310001914 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 657310001915 folate binding site [chemical binding]; other site 657310001916 NADP+ binding site [chemical binding]; other site 657310001917 epoxyqueuosine reductase; Region: TIGR00276 657310001918 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 657310001919 HEAT repeat; Region: HEAT; pfam02985 657310001920 hypothetical protein; Provisional; Region: PRK02539 657310001921 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 657310001922 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 657310001923 putative substrate translocation pore; other site 657310001924 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 657310001925 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 657310001926 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 657310001927 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 657310001928 dimer interface [polypeptide binding]; other site 657310001929 pyridoxal 5'-phosphate binding site [chemical binding]; other site 657310001930 catalytic residue [active] 657310001931 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 657310001932 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 657310001933 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 657310001934 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 657310001935 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 657310001936 nudix motif; other site 657310001937 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 657310001938 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 657310001939 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 657310001940 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 657310001941 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 657310001942 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 657310001943 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 657310001944 Walker A/P-loop; other site 657310001945 ATP binding site [chemical binding]; other site 657310001946 Q-loop/lid; other site 657310001947 ABC transporter signature motif; other site 657310001948 Walker B; other site 657310001949 D-loop; other site 657310001950 H-loop/switch region; other site 657310001951 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 657310001952 nudix motif; other site 657310001953 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 657310001954 DNA photolyase; Region: DNA_photolyase; pfam00875 657310001955 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 657310001956 active site turn [active] 657310001957 phosphorylation site [posttranslational modification] 657310001958 PTS system, glucose-like IIB component; Region: EIIB_glc; TIGR00826 657310001959 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 657310001960 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 657310001961 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 657310001962 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 657310001963 Ca binding site [ion binding]; other site 657310001964 active site 657310001965 catalytic site [active] 657310001966 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 657310001967 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 657310001968 Transcriptional regulators [Transcription]; Region: PurR; COG1609 657310001969 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 657310001970 DNA binding site [nucleotide binding] 657310001971 domain linker motif; other site 657310001972 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 657310001973 dimerization interface [polypeptide binding]; other site 657310001974 ligand binding site [chemical binding]; other site 657310001975 sodium binding site [ion binding]; other site 657310001976 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 657310001977 beta-galactosidase; Region: BGL; TIGR03356 657310001978 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 657310001979 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 657310001980 active site turn [active] 657310001981 phosphorylation site [posttranslational modification] 657310001982 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 657310001983 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 657310001984 HPr interaction site; other site 657310001985 glycerol kinase (GK) interaction site [polypeptide binding]; other site 657310001986 active site 657310001987 phosphorylation site [posttranslational modification] 657310001988 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 657310001989 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 657310001990 active site 657310001991 metal binding site [ion binding]; metal-binding site 657310001992 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 657310001993 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 657310001994 dimer interface [polypeptide binding]; other site 657310001995 conserved gate region; other site 657310001996 putative PBP binding loops; other site 657310001997 ABC-ATPase subunit interface; other site 657310001998 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 657310001999 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 657310002000 Walker A/P-loop; other site 657310002001 ATP binding site [chemical binding]; other site 657310002002 Q-loop/lid; other site 657310002003 ABC transporter signature motif; other site 657310002004 Walker B; other site 657310002005 D-loop; other site 657310002006 H-loop/switch region; other site 657310002007 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 657310002008 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 657310002009 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 657310002010 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 657310002011 putative active site [active] 657310002012 catalytic site [active] 657310002013 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 657310002014 putative active site [active] 657310002015 catalytic site [active] 657310002016 hypothetical protein; Provisional; Region: PRK04164 657310002017 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 657310002018 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 657310002019 DHH family; Region: DHH; pfam01368 657310002020 DHHA2 domain; Region: DHHA2; pfam02833 657310002021 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 657310002022 active site 657310002023 metal binding site [ion binding]; metal-binding site 657310002024 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 657310002025 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 657310002026 Ethanolamine utilisation protein EutQ; Region: EutQ; pfam06249 657310002027 ethanolamine utilization protein EutQ; Provisional; Region: PRK15457 657310002028 ethanolamine utilization protein; Region: eut_hyp; TIGR02536 657310002029 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; cl00920 657310002030 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 657310002031 1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059 657310002032 Hexamer interface [polypeptide binding]; other site 657310002033 Putative hexagonal pore residue; other site 657310002034 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 657310002035 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 657310002036 Hexamer interface [polypeptide binding]; other site 657310002037 Hexagonal pore residue; other site 657310002038 ethanolamine utilization protein EutL; Provisional; Region: PRK15405 657310002039 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_EutL_repeat1; cd07049 657310002040 putative hexamer interface [polypeptide binding]; other site 657310002041 putative hexagonal pore; other site 657310002042 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_EutL_repeat2; cd07050 657310002043 putative hexamer interface [polypeptide binding]; other site 657310002044 putative hexagonal pore; other site 657310002045 Ethanolamine ammonia-lyase, small subunit [Amino acid transport and metabolism]; Region: EutC; COG4302 657310002046 ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067 657310002047 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 657310002048 reactivating factor for ethanolamine ammonia lyase; Provisional; Region: eutA; PRK10719 657310002049 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 657310002050 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 657310002051 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 657310002052 Histidine kinase; Region: HisKA_2; pfam07568 657310002053 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 657310002054 ATP binding site [chemical binding]; other site 657310002055 Mg2+ binding site [ion binding]; other site 657310002056 G-X-G motif; other site 657310002057 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 657310002058 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 657310002059 active site 657310002060 phosphorylation site [posttranslational modification] 657310002061 intermolecular recognition site; other site 657310002062 dimerization interface [polypeptide binding]; other site 657310002063 ANTAR domain; Region: ANTAR; pfam03861 657310002064 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 657310002065 1,3-propanediol dehydrogenase (PPD) catalyzes the reduction of 3-hydroxypropionaldehyde (3-HPA) to 1,3-propanediol in glycerol metabolism; Region: PDD; cd08180 657310002066 putative active site [active] 657310002067 metal binding site [ion binding]; metal-binding site 657310002068 ATP:cob(I)alamin adenosyltransferase; Region: PduO_Nterm; TIGR00636 657310002069 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 657310002070 G1 box; other site 657310002071 GTP/Mg2+ binding site [chemical binding]; other site 657310002072 G2 box; other site 657310002073 Switch I region; other site 657310002074 G3 box; other site 657310002075 Switch II region; other site 657310002076 G4 box; other site 657310002077 G5 box; other site 657310002078 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 657310002079 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 657310002080 Walker A/P-loop; other site 657310002081 ATP binding site [chemical binding]; other site 657310002082 Q-loop/lid; other site 657310002083 ABC transporter signature motif; other site 657310002084 Walker B; other site 657310002085 D-loop; other site 657310002086 H-loop/switch region; other site 657310002087 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 657310002088 Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143 657310002089 putative binding site residues; other site 657310002090 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 657310002091 active site 657310002092 catalytic residues [active] 657310002093 CodY GAF-like domain; Region: CodY; pfam06018 657310002094 GTP-sensing transcriptional pleiotropic repressor CodY; Region: codY_Gpos; TIGR02787 657310002095 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 657310002096 putative DNA binding site [nucleotide binding]; other site 657310002097 putative Zn2+ binding site [ion binding]; other site 657310002098 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 657310002099 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 657310002100 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 657310002101 Walker A motif; other site 657310002102 ATP binding site [chemical binding]; other site 657310002103 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 657310002104 Walker B motif; other site 657310002105 arginine finger; other site 657310002106 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 657310002107 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 657310002108 active site 657310002109 HslU subunit interaction site [polypeptide binding]; other site 657310002110 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 657310002111 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 657310002112 active site 657310002113 Int/Topo IB signature motif; other site 657310002114 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 657310002115 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 657310002116 Topoisomerase IA [DNA replication, recombination, and repair]; Region: TopA; COG0550 657310002117 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 657310002118 active site 657310002119 interdomain interaction site; other site 657310002120 putative metal-binding site [ion binding]; other site 657310002121 nucleotide binding site [chemical binding]; other site 657310002122 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 657310002123 domain I; other site 657310002124 DNA binding groove [nucleotide binding] 657310002125 phosphate binding site [ion binding]; other site 657310002126 domain II; other site 657310002127 domain III; other site 657310002128 nucleotide binding site [chemical binding]; other site 657310002129 catalytic site [active] 657310002130 domain IV; other site 657310002131 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 657310002132 RNA/DNA hybrid binding site [nucleotide binding]; other site 657310002133 active site 657310002134 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 657310002135 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 657310002136 GTP/Mg2+ binding site [chemical binding]; other site 657310002137 G4 box; other site 657310002138 G5 box; other site 657310002139 G1 box; other site 657310002140 Switch I region; other site 657310002141 G2 box; other site 657310002142 G3 box; other site 657310002143 Switch II region; other site 657310002144 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 657310002145 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 657310002146 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 657310002147 Transcriptional regulator [Transcription]; Region: LysR; COG0583 657310002148 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 657310002149 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 657310002150 dimerization interface [polypeptide binding]; other site 657310002151 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 657310002152 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 657310002153 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 657310002154 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 657310002155 E3 interaction surface; other site 657310002156 lipoyl attachment site [posttranslational modification]; other site 657310002157 e3 binding domain; Region: E3_binding; pfam02817 657310002158 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 657310002159 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 657310002160 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 657310002161 tetramer interface [polypeptide binding]; other site 657310002162 TPP-binding site [chemical binding]; other site 657310002163 heterodimer interface [polypeptide binding]; other site 657310002164 phosphorylation loop region [posttranslational modification] 657310002165 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 657310002166 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 657310002167 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 657310002168 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 657310002169 nucleotide binding site [chemical binding]; other site 657310002170 Acetokinase family; Region: Acetate_kinase; cl17229 657310002171 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212 657310002172 TraX protein; Region: TraX; cl05434 657310002173 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 657310002174 MarR family; Region: MarR; pfam01047 657310002175 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 657310002176 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 657310002177 Zn binding site [ion binding]; other site 657310002178 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 657310002179 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 657310002180 FtsX-like permease family; Region: FtsX; pfam02687 657310002181 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 657310002182 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 657310002183 Walker A/P-loop; other site 657310002184 ATP binding site [chemical binding]; other site 657310002185 Q-loop/lid; other site 657310002186 ABC transporter signature motif; other site 657310002187 Walker B; other site 657310002188 D-loop; other site 657310002189 H-loop/switch region; other site 657310002190 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 657310002191 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 657310002192 Walker A/P-loop; other site 657310002193 ATP binding site [chemical binding]; other site 657310002194 Q-loop/lid; other site 657310002195 ABC transporter signature motif; other site 657310002196 Walker B; other site 657310002197 D-loop; other site 657310002198 H-loop/switch region; other site 657310002199 Predicted transcriptional regulators [Transcription]; Region: COG1725 657310002200 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 657310002201 DNA-binding site [nucleotide binding]; DNA binding site 657310002202 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 657310002203 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 657310002204 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 657310002205 protein binding site [polypeptide binding]; other site 657310002206 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 657310002207 Catalytic dyad [active] 657310002208 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 657310002209 hypothetical protein; Provisional; Region: PRK13672 657310002210 methionine sulfoxide reductase A; Provisional; Region: PRK14054 657310002211 Uncharacterized protein conserved in bacteria (DUF2140); Region: DUF2140; pfam09911 657310002212 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 657310002213 active site 657310002214 catalytic triad [active] 657310002215 oxyanion hole [active] 657310002216 EDD domain protein, DegV family; Region: DegV; TIGR00762 657310002217 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 657310002218 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 657310002219 active site 657310002220 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 657310002221 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 657310002222 NAD(P) binding site [chemical binding]; other site 657310002223 active site 657310002224 ribonuclease Z; Region: RNase_Z; TIGR02651 657310002225 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 657310002226 KH domain; Region: KH_4; pfam13083 657310002227 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 657310002228 Predicted flavoprotein [General function prediction only]; Region: COG0431 657310002229 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 657310002230 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 657310002231 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 657310002232 DNA binding residues [nucleotide binding] 657310002233 dimer interface [polypeptide binding]; other site 657310002234 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 657310002235 signal recognition particle protein; Provisional; Region: PRK10867 657310002236 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 657310002237 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 657310002238 P loop; other site 657310002239 GTP binding site [chemical binding]; other site 657310002240 Signal peptide binding domain; Region: SRP_SPB; pfam02978 657310002241 Uncharacterized conserved protein [Function unknown]; Region: COG1683 657310002242 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 657310002243 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 657310002244 active site 657310002245 phosphorylation site [posttranslational modification] 657310002246 intermolecular recognition site; other site 657310002247 dimerization interface [polypeptide binding]; other site 657310002248 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 657310002249 DNA binding site [nucleotide binding] 657310002250 aromatic amino acid aminotransferase; Validated; Region: PRK07309 657310002251 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 657310002252 pyridoxal 5'-phosphate binding site [chemical binding]; other site 657310002253 homodimer interface [polypeptide binding]; other site 657310002254 catalytic residue [active] 657310002255 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 657310002256 N-terminal catalytic domain of SPGH38, a putative alpha-mannosidase of Streptococcus pyogenes, and its prokaryotic homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_SpGH38_like; cd10814 657310002257 active site 657310002258 metal binding site [ion binding]; metal-binding site 657310002259 homodimer interface [polypeptide binding]; other site 657310002260 catalytic site [active] 657310002261 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 657310002262 Uncharacterized conserved protein [Function unknown]; Region: COG3538 657310002263 Protein of unknown function (DUF1237); Region: DUF1237; pfam06824 657310002264 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 657310002265 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 657310002266 DNA-binding site [nucleotide binding]; DNA binding site 657310002267 Transcriptional regulators [Transcription]; Region: PurR; COG1609 657310002268 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 657310002269 ligand binding site [chemical binding]; other site 657310002270 dimerization interface [polypeptide binding]; other site 657310002271 Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124 657310002272 active site 657310002273 zinc binding site [ion binding]; other site 657310002274 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 657310002275 active site 657310002276 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 657310002277 active site 657310002278 dimer interface [polypeptide binding]; other site 657310002279 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 657310002280 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 657310002281 heterodimer interface [polypeptide binding]; other site 657310002282 active site 657310002283 FMN binding site [chemical binding]; other site 657310002284 homodimer interface [polypeptide binding]; other site 657310002285 substrate binding site [chemical binding]; other site 657310002286 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 657310002287 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 657310002288 FAD binding pocket [chemical binding]; other site 657310002289 FAD binding motif [chemical binding]; other site 657310002290 phosphate binding motif [ion binding]; other site 657310002291 beta-alpha-beta structure motif; other site 657310002292 NAD binding pocket [chemical binding]; other site 657310002293 Iron coordination center [ion binding]; other site 657310002294 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 657310002295 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; smart01096 657310002296 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 657310002297 Carbamoylphosphate synthase large subunit (split gene in MJ) [Amino acid transport and metabolism / Nucleotide transport and metabolism]; Region: CarB; COG0458 657310002298 ATP-grasp domain; Region: ATP-grasp_4; cl17255 657310002299 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 657310002300 IMP binding site; other site 657310002301 dimer interface [polypeptide binding]; other site 657310002302 interdomain contacts; other site 657310002303 partial ornithine binding site; other site 657310002304 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 657310002305 Carbamoylphosphate synthase large subunit (split gene in MJ) [Amino acid transport and metabolism / Nucleotide transport and metabolism]; Region: CarB; COG0458 657310002306 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 657310002307 dihydroorotase; Validated; Region: pyrC; PRK09357 657310002308 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 657310002309 active site 657310002310 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 657310002311 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 657310002312 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 657310002313 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 657310002314 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 657310002315 active site 657310002316 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 657310002317 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 657310002318 RNA binding surface [nucleotide binding]; other site 657310002319 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 657310002320 active site 657310002321 lipoprotein signal peptidase; Provisional; Region: PRK14797 657310002322 lipoprotein signal peptidase; Provisional; Region: PRK14787 657310002323 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 657310002324 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 657310002325 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 657310002326 Potassium binding sites [ion binding]; other site 657310002327 Cesium cation binding sites [ion binding]; other site 657310002328 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 657310002329 DNA-binding site [nucleotide binding]; DNA binding site 657310002330 RNA-binding motif; other site 657310002331 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 657310002332 RNA/DNA hybrid binding site [nucleotide binding]; other site 657310002333 active site 657310002334 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 657310002335 putative deacylase active site [active] 657310002336 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 657310002337 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 657310002338 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 657310002339 Walker A/P-loop; other site 657310002340 ATP binding site [chemical binding]; other site 657310002341 Q-loop/lid; other site 657310002342 ABC transporter signature motif; other site 657310002343 Walker B; other site 657310002344 D-loop; other site 657310002345 H-loop/switch region; other site 657310002346 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 657310002347 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 657310002348 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 657310002349 Walker A/P-loop; other site 657310002350 ATP binding site [chemical binding]; other site 657310002351 Q-loop/lid; other site 657310002352 ABC transporter signature motif; other site 657310002353 Walker B; other site 657310002354 D-loop; other site 657310002355 H-loop/switch region; other site 657310002356 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3763 657310002357 endonuclease IV; Provisional; Region: PRK01060 657310002358 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 657310002359 AP (apurinic/apyrimidinic) site pocket; other site 657310002360 DNA interaction; other site 657310002361 Metal-binding active site; metal-binding site 657310002362 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 657310002363 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 657310002364 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 657310002365 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 657310002366 active site 657310002367 HIGH motif; other site 657310002368 dimer interface [polypeptide binding]; other site 657310002369 KMSKS motif; other site 657310002370 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 657310002371 RNA binding surface [nucleotide binding]; other site 657310002372 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 657310002373 DNA binding site [nucleotide binding] 657310002374 domain linker motif; other site 657310002375 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 657310002376 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 657310002377 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 657310002378 active site 657310002379 YtxH-like protein; Region: YtxH; pfam12732 657310002380 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 657310002381 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 657310002382 active site 657310002383 tetramer interface; other site 657310002384 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 657310002385 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 657310002386 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 657310002387 HPr kinase/phosphorylase; Provisional; Region: PRK05428 657310002388 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 657310002389 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 657310002390 Hpr binding site; other site 657310002391 active site 657310002392 homohexamer subunit interaction site [polypeptide binding]; other site 657310002393 Membrane protein of unknown function; Region: DUF360; pfam04020 657310002394 PspC domain; Region: PspC; pfam04024 657310002395 Uncharacterized conserved protein [Function unknown]; Region: COG3595 657310002396 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 657310002397 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 657310002398 PhoU domain; Region: PhoU; pfam01895 657310002399 PhoU domain; Region: PhoU; pfam01895 657310002400 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14255 657310002401 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 657310002402 Walker A/P-loop; other site 657310002403 ATP binding site [chemical binding]; other site 657310002404 Q-loop/lid; other site 657310002405 ABC transporter signature motif; other site 657310002406 Walker B; other site 657310002407 D-loop; other site 657310002408 H-loop/switch region; other site 657310002409 phosphate transporter ATP-binding protein; Provisional; Region: PRK14237 657310002410 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 657310002411 Walker A/P-loop; other site 657310002412 ATP binding site [chemical binding]; other site 657310002413 Q-loop/lid; other site 657310002414 ABC transporter signature motif; other site 657310002415 Walker B; other site 657310002416 D-loop; other site 657310002417 H-loop/switch region; other site 657310002418 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 657310002419 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 657310002420 dimer interface [polypeptide binding]; other site 657310002421 conserved gate region; other site 657310002422 putative PBP binding loops; other site 657310002423 ABC-ATPase subunit interface; other site 657310002424 phosphate binding protein; Region: ptsS_2; TIGR02136 657310002425 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 657310002426 CRISPR/Cas system-associated protein Csn2; Region: Csn2_like; cl09913 657310002427 tetramer interface [polypeptide binding]; other site 657310002428 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cl11442 657310002429 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 657310002430 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 657310002431 FtsX-like permease family; Region: FtsX; pfam02687 657310002432 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 657310002433 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 657310002434 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 657310002435 nucleotide binding region [chemical binding]; other site 657310002436 ATP-binding site [chemical binding]; other site 657310002437 SEC-C motif; Region: SEC-C; pfam02810 657310002438 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 657310002439 30S subunit binding site; other site 657310002440 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 657310002441 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 657310002442 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 657310002443 ATP-binding cassette domain of non-transporter proteins; Region: ABC_Class2; cd03227 657310002444 Walker A/P-loop; other site 657310002445 Walker A/P-loop; other site 657310002446 ATP binding site [chemical binding]; other site 657310002447 ATP binding site [chemical binding]; other site 657310002448 Q-loop/lid; other site 657310002449 ABC transporter signature motif; other site 657310002450 Walker B; other site 657310002451 D-loop; other site 657310002452 H-loop/switch region; other site 657310002453 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 657310002454 active site 657310002455 P-loop; other site 657310002456 phosphorylation site [posttranslational modification] 657310002457 Uncharacterized conserved protein [Function unknown]; Region: COG1739 657310002458 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 657310002459 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 657310002460 Protein of unknown function (DUF2829); Region: DUF2829; pfam11195 657310002461 classical (c) SDRs; Region: SDR_c; cd05233 657310002462 NAD(P) binding site [chemical binding]; other site 657310002463 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 657310002464 active site 657310002465 QueT transporter; Region: QueT; pfam06177 657310002466 Tim44-like domain; Region: Tim44; cl09208 657310002467 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 657310002468 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 657310002469 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 657310002470 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 657310002471 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 657310002472 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 657310002473 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 657310002474 purine monophosphate binding site [chemical binding]; other site 657310002475 dimer interface [polypeptide binding]; other site 657310002476 putative catalytic residues [active] 657310002477 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 657310002478 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 657310002479 Folate-dependent phosphoribosylglycinamide formyltransferase PurN [Nucleotide transport and metabolism]; Region: PurN; COG0299 657310002480 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 657310002481 active site 657310002482 substrate binding site [chemical binding]; other site 657310002483 cosubstrate binding site; other site 657310002484 catalytic site [active] 657310002485 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 657310002486 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 657310002487 dimerization interface [polypeptide binding]; other site 657310002488 putative ATP binding site [chemical binding]; other site 657310002489 amidophosphoribosyltransferase; Provisional; Region: PRK07272 657310002490 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 657310002491 active site 657310002492 tetramer interface [polypeptide binding]; other site 657310002493 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 657310002494 active site 657310002495 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 657310002496 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 657310002497 dimerization interface [polypeptide binding]; other site 657310002498 ATP binding site [chemical binding]; other site 657310002499 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 657310002500 dimerization interface [polypeptide binding]; other site 657310002501 ATP binding site [chemical binding]; other site 657310002502 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 657310002503 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 657310002504 putative active site [active] 657310002505 catalytic triad [active] 657310002506 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700 657310002507 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 657310002508 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 657310002509 ATP binding site [chemical binding]; other site 657310002510 active site 657310002511 substrate binding site [chemical binding]; other site 657310002512 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 657310002513 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 657310002514 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_2; cd03402 657310002515 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 657310002516 putative substrate binding site [chemical binding]; other site 657310002517 putative ATP binding site [chemical binding]; other site 657310002518 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 657310002519 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 657310002520 peptide binding site [polypeptide binding]; other site 657310002521 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 657310002522 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 657310002523 homodimer interface [polypeptide binding]; other site 657310002524 substrate-cofactor binding pocket; other site 657310002525 catalytic residue [active] 657310002526 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4876 657310002527 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 657310002528 active pocket/dimerization site; other site 657310002529 active site 657310002530 phosphorylation site [posttranslational modification] 657310002531 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 657310002532 PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609 657310002533 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 657310002534 active site 657310002535 phosphorylation site [posttranslational modification] 657310002536 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 657310002537 ATP binding site [chemical binding]; other site 657310002538 substrate binding site [chemical binding]; other site 657310002539 tagatose 1,6-diphosphate aldolase; Reviewed; Region: PRK12399 657310002540 putative sugar isomerase, AgaS family; Region: agaS_fam; TIGR02815 657310002541 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 657310002542 dimer interface [polypeptide binding]; other site 657310002543 active site 657310002544 AgaS-like protein. AgaS contains a SIS (Sugar ISomerase) domain which is found in many phosphosugar isomerases and phosphosugar binding proteins. AgaS is a putative isomerase in Escherichia coli. It is similar to the glucosamine-6-phosphate synthases; Region: SIS_AgaS_like; cd05010 657310002545 putative active site [active] 657310002546 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 657310002547 UTRA domain; Region: UTRA; pfam07702 657310002548 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 657310002549 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 657310002550 DNA-binding site [nucleotide binding]; DNA binding site 657310002551 Transcriptional regulator [Transcription]; Region: LysR; COG0583 657310002552 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 657310002553 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 657310002554 putative hydrolase; Provisional; Region: PRK02113 657310002555 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 657310002556 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 657310002557 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 657310002558 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 657310002559 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 657310002560 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 657310002561 active site 657310002562 Zn binding site [ion binding]; other site 657310002563 Accessory gene regulator B; Region: AgrB; smart00793 657310002564 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 657310002565 active site 657310002566 phosphorylation site [posttranslational modification] 657310002567 intermolecular recognition site; other site 657310002568 dimerization interface [polypeptide binding]; other site 657310002569 N-acetylmuramoyl-L-alanine amidase; Validated; Region: PRK08581 657310002570 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 657310002571 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 657310002572 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 657310002573 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 657310002574 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 657310002575 NodB motif; other site 657310002576 active site 657310002577 catalytic site [active] 657310002578 Zn binding site [ion binding]; other site 657310002579 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 657310002580 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 657310002581 manganese transport protein MntH; Reviewed; Region: PRK00701 657310002582 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 657310002583 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 657310002584 Mitomycin C resistance protein (MRD); Region: MRD; cd07235 657310002585 dimer interface [polypeptide binding]; other site 657310002586 ligand binding site [chemical binding]; other site 657310002587 Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; pfam10110 657310002588 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579 657310002589 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 657310002590 putative active site [active] 657310002591 catalytic site [active] 657310002592 putative metal binding site [ion binding]; other site 657310002593 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 657310002594 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 657310002595 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 657310002596 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 657310002597 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 657310002598 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 657310002599 Predicted membrane protein [Function unknown]; Region: COG4129 657310002600 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 657310002601 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 657310002602 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 657310002603 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 657310002604 nucleotide binding site [chemical binding]; other site 657310002605 Haemolytic domain; Region: Haemolytic; pfam01809 657310002606 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 657310002607 G1 box; other site 657310002608 GTP/Mg2+ binding site [chemical binding]; other site 657310002609 Switch I region; other site 657310002610 G2 box; other site 657310002611 G3 box; other site 657310002612 Switch II region; other site 657310002613 G4 box; other site 657310002614 G5 box; other site 657310002615 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 657310002616 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 657310002617 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 657310002618 Walker A motif; other site 657310002619 ATP binding site [chemical binding]; other site 657310002620 Walker B motif; other site 657310002621 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 657310002622 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 657310002623 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 657310002624 Coenzyme A binding pocket [chemical binding]; other site 657310002625 C4-dicarboxylate transporter [Energy production and conversion]; Region: DcuC; cl17322 657310002626 5-bromo-4-chloroindolyl phosphate hydrolysis protein; Region: Halogen_Hydrol; cl02059 657310002627 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 657310002628 amphipathic channel; other site 657310002629 Asn-Pro-Ala signature motifs; other site 657310002630 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 657310002631 glycerol kinase; Provisional; Region: glpK; PRK00047 657310002632 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 657310002633 N- and C-terminal domain interface [polypeptide binding]; other site 657310002634 active site 657310002635 MgATP binding site [chemical binding]; other site 657310002636 catalytic site [active] 657310002637 metal binding site [ion binding]; metal-binding site 657310002638 glycerol binding site [chemical binding]; other site 657310002639 homotetramer interface [polypeptide binding]; other site 657310002640 homodimer interface [polypeptide binding]; other site 657310002641 FBP binding site [chemical binding]; other site 657310002642 protein IIAGlc interface [polypeptide binding]; other site 657310002643 Mga helix-turn-helix domain; Region: Mga; pfam05043 657310002644 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 657310002645 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 657310002646 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 657310002647 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 657310002648 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 657310002649 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 657310002650 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 657310002651 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 657310002652 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 657310002653 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 657310002654 Predicted membrane protein [Function unknown]; Region: COG2364 657310002655 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 657310002656 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 657310002657 ligand binding site [chemical binding]; other site 657310002658 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 657310002659 putative switch regulator; other site 657310002660 non-specific DNA interactions [nucleotide binding]; other site 657310002661 DNA binding site [nucleotide binding] 657310002662 sequence specific DNA binding site [nucleotide binding]; other site 657310002663 putative cAMP binding site [chemical binding]; other site 657310002664 Protein of unknown function (DUF3224); Region: DUF3224; pfam11528 657310002665 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 657310002666 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 657310002667 putative substrate translocation pore; other site 657310002668 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 657310002669 A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710 657310002670 putative active site [active] 657310002671 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 657310002672 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 657310002673 dimer interface [polypeptide binding]; other site 657310002674 active site 657310002675 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 657310002676 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 657310002677 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 657310002678 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 657310002679 active site 657310002680 phosphorylation site [posttranslational modification] 657310002681 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01096 657310002682 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 657310002683 Zn2+ binding site [ion binding]; other site 657310002684 Mg2+ binding site [ion binding]; other site 657310002685 enolase; Provisional; Region: eno; PRK00077 657310002686 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 657310002687 dimer interface [polypeptide binding]; other site 657310002688 metal binding site [ion binding]; metal-binding site 657310002689 substrate binding pocket [chemical binding]; other site 657310002690 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 657310002691 triosephosphate isomerase; Provisional; Region: PRK14565 657310002692 substrate binding site [chemical binding]; other site 657310002693 dimer interface [polypeptide binding]; other site 657310002694 catalytic triad [active] 657310002695 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 657310002696 Phosphoglycerate kinase; Region: PGK; pfam00162 657310002697 substrate binding site [chemical binding]; other site 657310002698 hinge regions; other site 657310002699 ADP binding site [chemical binding]; other site 657310002700 catalytic site [active] 657310002701 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 657310002702 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 657310002703 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 657310002704 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 657310002705 Predicted transcriptional regulator [Transcription]; Region: COG3388 657310002706 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 657310002707 Uncharacterized conserved protein [Function unknown]; Region: COG1284 657310002708 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 657310002709 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 657310002710 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 657310002711 Protein of unknown function (DUF436); Region: DUF436; pfam04260 657310002712 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; pfam07155 657310002713 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 657310002714 dimer interface [polypeptide binding]; other site 657310002715 substrate binding site [chemical binding]; other site 657310002716 ATP binding site [chemical binding]; other site 657310002717 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 657310002718 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 657310002719 dimer interface [polypeptide binding]; other site 657310002720 anticodon binding site; other site 657310002721 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 657310002722 homodimer interface [polypeptide binding]; other site 657310002723 motif 1; other site 657310002724 active site 657310002725 motif 2; other site 657310002726 GAD domain; Region: GAD; pfam02938 657310002727 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 657310002728 motif 3; other site 657310002729 histidyl-tRNA synthetase; Region: hisS; TIGR00442 657310002730 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 657310002731 dimer interface [polypeptide binding]; other site 657310002732 motif 1; other site 657310002733 active site 657310002734 motif 2; other site 657310002735 motif 3; other site 657310002736 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 657310002737 anticodon binding site; other site 657310002738 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 657310002739 putative active site [active] 657310002740 dimerization interface [polypeptide binding]; other site 657310002741 putative tRNAtyr binding site [nucleotide binding]; other site 657310002742 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 657310002743 HD domain; Region: HD_4; pfam13328 657310002744 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 657310002745 synthetase active site [active] 657310002746 NTP binding site [chemical binding]; other site 657310002747 metal binding site [ion binding]; metal-binding site 657310002748 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 657310002749 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 657310002750 RNA methyltransferase, RsmE family; Region: TIGR00046 657310002751 RNA methyltransferase; Region: Methyltrans_RNA; pfam04452 657310002752 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 657310002753 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 657310002754 S-adenosylmethionine binding site [chemical binding]; other site 657310002755 Protein of unknown function (DUF3013); Region: DUF3013; pfam11217 657310002756 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 657310002757 active site 657310002758 DNA binding site [nucleotide binding] 657310002759 recombination factor protein RarA; Reviewed; Region: PRK13342 657310002760 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 657310002761 Walker A motif; other site 657310002762 ATP binding site [chemical binding]; other site 657310002763 Walker B motif; other site 657310002764 arginine finger; other site 657310002765 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 657310002766 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 657310002767 Predicted transcriptional regulators [Transcription]; Region: COG1695 657310002768 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 657310002769 putative DNA binding site [nucleotide binding]; other site 657310002770 putative Zn2+ binding site [ion binding]; other site 657310002771 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 657310002772 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 657310002773 active site 657310002774 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 657310002775 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 657310002776 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 657310002777 Bacteriophage holin; Region: Phage_holin_1; pfam04531 657310002778 Phage uncharacterized protein (Phage_XkdX); Region: Phage_XkdX; pfam09693 657310002779 Domain of unknown function (DUF2479); Region: DUF2479; pfam10651 657310002780 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1483 657310002781 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 657310002782 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 657310002783 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 657310002784 Domain of unknown function (DUF4355); Region: DUF4355; pfam14265 657310002785 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 657310002786 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 657310002787 phage portal protein, SPP1 family; Region: portal_SPP1; TIGR01538 657310002788 Phage terminase large subunit; Region: Terminase_3; cl12054 657310002789 Phage terminase small subunit; Region: Phage_terminase; pfam10668 657310002790 Uncharacterized conserved protein [Function unknown]; Region: COG5484 657310002791 Beta protein; Region: Beta_protein; pfam14350 657310002792 Endodeoxyribonuclease RusA; Region: RusA; pfam05866 657310002793 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u3; cd11540 657310002794 putative metal binding site [ion binding]; other site 657310002795 RecT family; Region: RecT; cl04285 657310002796 Uncharacterized phage-encoded protein [Function unknown]; Region: COG3646 657310002797 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 657310002798 ORF6C domain; Region: ORF6C; pfam10552 657310002799 phage-associated protein, BcepMu gp16 family; Region: BcepMu_gp16; TIGR04111 657310002800 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 657310002801 non-specific DNA binding site [nucleotide binding]; other site 657310002802 salt bridge; other site 657310002803 sequence-specific DNA binding site [nucleotide binding]; other site 657310002804 Domain of unknown function (DUF955); Region: DUF955; pfam06114 657310002805 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 657310002806 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 657310002807 Int/Topo IB signature motif; other site 657310002808 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 657310002809 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 657310002810 Walker A motif; other site 657310002811 ATP binding site [chemical binding]; other site 657310002812 Walker B motif; other site 657310002813 amino acid transporter; Region: 2A0306; TIGR00909 657310002814 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 657310002815 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 657310002816 FtsX-like permease family; Region: FtsX; pfam02687 657310002817 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 657310002818 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 657310002819 Walker A/P-loop; other site 657310002820 ATP binding site [chemical binding]; other site 657310002821 Q-loop/lid; other site 657310002822 ABC transporter signature motif; other site 657310002823 Walker B; other site 657310002824 D-loop; other site 657310002825 H-loop/switch region; other site 657310002826 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 657310002827 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 657310002828 DNA-binding site [nucleotide binding]; DNA binding site 657310002829 UTRA domain; Region: UTRA; pfam07702 657310002830 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 657310002831 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 657310002832 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 657310002833 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 657310002834 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 657310002835 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 657310002836 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 657310002837 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 657310002838 substrate binding pocket [chemical binding]; other site 657310002839 chain length determination region; other site 657310002840 substrate-Mg2+ binding site; other site 657310002841 catalytic residues [active] 657310002842 aspartate-rich region 1; other site 657310002843 active site lid residues [active] 657310002844 aspartate-rich region 2; other site 657310002845 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 657310002846 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 657310002847 ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247 657310002848 Walker A/P-loop; other site 657310002849 ATP binding site [chemical binding]; other site 657310002850 Q-loop/lid; other site 657310002851 ABC transporter signature motif; other site 657310002852 Walker B; other site 657310002853 D-loop; other site 657310002854 H-loop/switch region; other site 657310002855 thiol reductant ABC exporter, CydD subunit; Region: CydD; TIGR02857 657310002856 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 657310002857 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 657310002858 Walker A/P-loop; other site 657310002859 ATP binding site [chemical binding]; other site 657310002860 Q-loop/lid; other site 657310002861 ABC transporter signature motif; other site 657310002862 Walker B; other site 657310002863 D-loop; other site 657310002864 H-loop/switch region; other site 657310002865 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 657310002866 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 657310002867 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 657310002868 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 657310002869 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 657310002870 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 657310002871 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 657310002872 Protein of unknown function (DUF1033); Region: DUF1033; pfam06279 657310002873 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 657310002874 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 657310002875 WHG domain; Region: WHG; pfam13305 657310002876 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 657310002877 substrate binding site [chemical binding]; other site 657310002878 drug efflux system protein MdtG; Provisional; Region: PRK09874 657310002879 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 657310002880 putative substrate translocation pore; other site 657310002881 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 657310002882 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 657310002883 Putative amino acid metabolism; Region: DUF1831; pfam08866 657310002884 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 657310002885 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 657310002886 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 657310002887 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 657310002888 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 657310002889 ABC-ATPase subunit interface; other site 657310002890 dimer interface [polypeptide binding]; other site 657310002891 putative PBP binding regions; other site 657310002892 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 657310002893 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 657310002894 metal binding site [ion binding]; metal-binding site 657310002895 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 657310002896 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_subfamily5; cd08019 657310002897 metal binding site [ion binding]; metal-binding site 657310002898 putative dimer interface [polypeptide binding]; other site 657310002899 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 657310002900 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 657310002901 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 657310002902 dimer interface [polypeptide binding]; other site 657310002903 conserved gate region; other site 657310002904 ABC-ATPase subunit interface; other site 657310002905 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 657310002906 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 657310002907 Walker A/P-loop; other site 657310002908 ATP binding site [chemical binding]; other site 657310002909 Q-loop/lid; other site 657310002910 ABC transporter signature motif; other site 657310002911 Walker B; other site 657310002912 D-loop; other site 657310002913 H-loop/switch region; other site 657310002914 NIL domain; Region: NIL; pfam09383 657310002915 Glucosyl transferase GtrII; Region: Glucos_trans_II; pfam14264 657310002916 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 657310002917 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 657310002918 glutaminase active site [active] 657310002919 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 657310002920 dimer interface [polypeptide binding]; other site 657310002921 active site 657310002922 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 657310002923 dimer interface [polypeptide binding]; other site 657310002924 active site 657310002925 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 657310002926 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 657310002927 Walker A/P-loop; other site 657310002928 ATP binding site [chemical binding]; other site 657310002929 Q-loop/lid; other site 657310002930 ABC transporter signature motif; other site 657310002931 Walker B; other site 657310002932 D-loop; other site 657310002933 H-loop/switch region; other site 657310002934 ATP-binding cassette cobalt transporter; Region: DUF3744; pfam12558 657310002935 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 657310002936 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 657310002937 Walker A/P-loop; other site 657310002938 ATP binding site [chemical binding]; other site 657310002939 Q-loop/lid; other site 657310002940 ABC transporter signature motif; other site 657310002941 Walker B; other site 657310002942 D-loop; other site 657310002943 H-loop/switch region; other site 657310002944 hypothetical protein; Provisional; Region: PRK13661 657310002945 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 657310002946 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 657310002947 YbbR-like protein; Region: YbbR; pfam07949 657310002948 Uncharacterized conserved protein [Function unknown]; Region: COG1624 657310002949 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 657310002950 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 657310002951 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 657310002952 dimer interface [polypeptide binding]; other site 657310002953 PYR/PP interface [polypeptide binding]; other site 657310002954 TPP binding site [chemical binding]; other site 657310002955 substrate binding site [chemical binding]; other site 657310002956 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 657310002957 Domain of unknown function; Region: EKR; smart00890 657310002958 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 657310002959 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 657310002960 TPP-binding site [chemical binding]; other site 657310002961 dimer interface [polypeptide binding]; other site 657310002962 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 657310002963 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 657310002964 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 657310002965 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 657310002966 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 657310002967 DNA binding residues [nucleotide binding] 657310002968 putative dimer interface [polypeptide binding]; other site 657310002969 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 657310002970 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 657310002971 HflX GTPase family; Region: HflX; cd01878 657310002972 G1 box; other site 657310002973 GTP/Mg2+ binding site [chemical binding]; other site 657310002974 Switch I region; other site 657310002975 G2 box; other site 657310002976 G3 box; other site 657310002977 Switch II region; other site 657310002978 G4 box; other site 657310002979 G5 box; other site 657310002980 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 657310002981 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 657310002982 active site 657310002983 catalytic site [active] 657310002984 metal binding site [ion binding]; metal-binding site 657310002985 dimer interface [polypeptide binding]; other site 657310002986 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 657310002987 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 657310002988 NAD(P) binding site [chemical binding]; other site 657310002989 active site 657310002990 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 657310002991 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 657310002992 active site 657310002993 nucleotide binding site [chemical binding]; other site 657310002994 HIGH motif; other site 657310002995 KMSKS motif; other site 657310002996 Core-2/I-Branching enzyme; Region: Branch; pfam02485 657310002997 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 657310002998 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 657310002999 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 657310003000 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 657310003001 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 657310003002 active site 657310003003 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 657310003004 Bacterial sugar transferase; Region: Bac_transf; pfam02397 657310003005 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 657310003006 Methyltransferase domain; Region: Methyltransf_23; pfam13489 657310003007 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 657310003008 S-adenosylmethionine binding site [chemical binding]; other site 657310003009 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 657310003010 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 657310003011 Walker A/P-loop; other site 657310003012 ATP binding site [chemical binding]; other site 657310003013 Q-loop/lid; other site 657310003014 ABC transporter signature motif; other site 657310003015 Walker B; other site 657310003016 D-loop; other site 657310003017 H-loop/switch region; other site 657310003018 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 657310003019 putative carbohydrate binding site [chemical binding]; other site 657310003020 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 657310003021 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 657310003022 Uncharacterized conserved protein (DUF2304); Region: DUF2304; cl01034 657310003023 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 657310003024 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 657310003025 Ligand binding site; other site 657310003026 Putative Catalytic site; other site 657310003027 DXD motif; other site 657310003028 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 657310003029 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 657310003030 NADP binding site [chemical binding]; other site 657310003031 active site 657310003032 putative substrate binding site [chemical binding]; other site 657310003033 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 657310003034 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 657310003035 NAD binding site [chemical binding]; other site 657310003036 substrate binding site [chemical binding]; other site 657310003037 homodimer interface [polypeptide binding]; other site 657310003038 active site 657310003039 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 657310003040 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 657310003041 substrate binding site; other site 657310003042 tetramer interface; other site 657310003043 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 657310003044 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196 657310003045 Probable Catalytic site; other site 657310003046 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 657310003047 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 657310003048 active site 657310003049 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 657310003050 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 657310003051 Probable Catalytic site; other site 657310003052 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 657310003053 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 657310003054 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 657310003055 Mg++ binding site [ion binding]; other site 657310003056 putative catalytic motif [active] 657310003057 substrate binding site [chemical binding]; other site 657310003058 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 657310003059 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 657310003060 active site 657310003061 flavodoxin; Validated; Region: PRK07308 657310003062 TspO/MBR family; Region: TspO_MBR; pfam03073 657310003063 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 657310003064 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 657310003065 WHG domain; Region: WHG; pfam13305 657310003066 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 657310003067 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 657310003068 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 657310003069 pentamer interface [polypeptide binding]; other site 657310003070 dodecaamer interface [polypeptide binding]; other site 657310003071 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 657310003072 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 657310003073 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298 657310003074 Protein of unknown function (DUF1093); Region: DUF1093; cl02185 657310003075 37-kD nucleoid-associated bacterial protein; Region: NA37; cl15473 657310003076 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 657310003077 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 657310003078 active site turn [active] 657310003079 phosphorylation site [posttranslational modification] 657310003080 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 657310003081 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 657310003082 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 657310003083 putative metal binding site [ion binding]; other site 657310003084 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 657310003085 putative hydrophobic ligand binding site [chemical binding]; other site 657310003086 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 657310003087 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 657310003088 Protein of unknown function, DUF624; Region: DUF624; cl02369 657310003089 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 657310003090 Domain of unknown function (DUF3502); Region: DUF3502; pfam12010 657310003091 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 657310003092 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 657310003093 dimer interface [polypeptide binding]; other site 657310003094 ABC-ATPase subunit interface; other site 657310003095 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 657310003096 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 657310003097 dimer interface [polypeptide binding]; other site 657310003098 conserved gate region; other site 657310003099 putative PBP binding loops; other site 657310003100 ABC-ATPase subunit interface; other site 657310003101 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 657310003102 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 657310003103 DNA binding residues [nucleotide binding] 657310003104 dimer interface [polypeptide binding]; other site 657310003105 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 657310003106 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 657310003107 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 657310003108 Walker A/P-loop; other site 657310003109 ATP binding site [chemical binding]; other site 657310003110 Q-loop/lid; other site 657310003111 ABC transporter signature motif; other site 657310003112 Walker B; other site 657310003113 D-loop; other site 657310003114 H-loop/switch region; other site 657310003115 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 657310003116 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 657310003117 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 657310003118 Walker A/P-loop; other site 657310003119 ATP binding site [chemical binding]; other site 657310003120 Q-loop/lid; other site 657310003121 ABC transporter signature motif; other site 657310003122 Walker B; other site 657310003123 D-loop; other site 657310003124 H-loop/switch region; other site 657310003125 Tryptophanyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: TrpS; COG0180 657310003126 active site 657310003127 KMSKS motif; other site 657310003128 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 657310003129 active site 657310003130 HIGH motif; other site 657310003131 nucleotide binding site [chemical binding]; other site 657310003132 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 657310003133 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 657310003134 dimer interface [polypeptide binding]; other site 657310003135 conserved gate region; other site 657310003136 putative PBP binding loops; other site 657310003137 ABC-ATPase subunit interface; other site 657310003138 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 657310003139 dimer interface [polypeptide binding]; other site 657310003140 putative PBP binding loops; other site 657310003141 ABC-ATPase subunit interface; other site 657310003142 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 657310003143 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 657310003144 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 657310003145 Uncharacterized protein conserved in bacteria (DUF2264); Region: DUF2264; pfam10022 657310003146 Transcriptional regulators [Transcription]; Region: PurR; COG1609 657310003147 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 657310003148 DNA binding site [nucleotide binding] 657310003149 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 657310003150 putative dimerization interface [polypeptide binding]; other site 657310003151 putative ligand binding site [chemical binding]; other site 657310003152 GTP-binding protein LepA; Provisional; Region: PRK05433 657310003153 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 657310003154 G1 box; other site 657310003155 putative GEF interaction site [polypeptide binding]; other site 657310003156 GTP/Mg2+ binding site [chemical binding]; other site 657310003157 Switch I region; other site 657310003158 G2 box; other site 657310003159 G3 box; other site 657310003160 Switch II region; other site 657310003161 G4 box; other site 657310003162 G5 box; other site 657310003163 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 657310003164 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 657310003165 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 657310003166 Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527 657310003167 Sterol carrier protein domain; Region: SCP2_2; pfam13530 657310003168 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014 657310003169 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 657310003170 Clp amino terminal domain; Region: Clp_N; pfam02861 657310003171 Clp amino terminal domain; Region: Clp_N; pfam02861 657310003172 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 657310003173 Walker A motif; other site 657310003174 ATP binding site [chemical binding]; other site 657310003175 Walker B motif; other site 657310003176 arginine finger; other site 657310003177 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 657310003178 Walker A motif; other site 657310003179 ATP binding site [chemical binding]; other site 657310003180 Walker B motif; other site 657310003181 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 657310003182 DoxX; Region: DoxX; cl17842 657310003183 adenylosuccinate lyase; Provisional; Region: PRK07492 657310003184 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 657310003185 tetramer interface [polypeptide binding]; other site 657310003186 active site 657310003187 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 657310003188 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 657310003189 NAD binding site [chemical binding]; other site 657310003190 ATP-grasp domain; Region: ATP-grasp; pfam02222 657310003191 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 657310003192 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 657310003193 putative dimer interface [polypeptide binding]; other site 657310003194 putative anticodon binding site; other site 657310003195 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 657310003196 homodimer interface [polypeptide binding]; other site 657310003197 motif 1; other site 657310003198 motif 2; other site 657310003199 active site 657310003200 motif 3; other site 657310003201 aspartate aminotransferase; Provisional; Region: PRK05764 657310003202 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 657310003203 pyridoxal 5'-phosphate binding site [chemical binding]; other site 657310003204 homodimer interface [polypeptide binding]; other site 657310003205 catalytic residue [active] 657310003206 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 657310003207 DnaQ family exonuclease/DinG family helicase, putative; Region: dinG_rel; TIGR01407 657310003208 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 657310003209 active site 657310003210 catalytic site [active] 657310003211 substrate binding site [chemical binding]; other site 657310003212 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 657310003213 ATP binding site [chemical binding]; other site 657310003214 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 657310003215 prolyl-tRNA synthetase; Provisional; Region: PRK09194 657310003216 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 657310003217 dimer interface [polypeptide binding]; other site 657310003218 motif 1; other site 657310003219 active site 657310003220 motif 2; other site 657310003221 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 657310003222 putative deacylase active site [active] 657310003223 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 657310003224 active site 657310003225 motif 3; other site 657310003226 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 657310003227 anticodon binding site; other site 657310003228 RIP metalloprotease RseP; Region: TIGR00054 657310003229 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 657310003230 active site 657310003231 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 657310003232 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 657310003233 protein binding site [polypeptide binding]; other site 657310003234 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 657310003235 putative substrate binding region [chemical binding]; other site 657310003236 glucose-1-dehydrogenase; Provisional; Region: PRK08936 657310003237 glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358 657310003238 NAD binding site [chemical binding]; other site 657310003239 homodimer interface [polypeptide binding]; other site 657310003240 active site 657310003241 Predicted membrane protein [Function unknown]; Region: COG2364 657310003242 TIGR02594 family protein; Region: TIGR02594 657310003243 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 657310003244 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 657310003245 active site 657310003246 phosphorylation site [posttranslational modification] 657310003247 intermolecular recognition site; other site 657310003248 dimerization interface [polypeptide binding]; other site 657310003249 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 657310003250 DNA binding residues [nucleotide binding] 657310003251 dimerization interface [polypeptide binding]; other site 657310003252 Asparagine synthase; Region: Asn_synthase; pfam00733 657310003253 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 657310003254 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 657310003255 Transglutaminase-like superfamily; Region: Transglut_core3; pfam13471 657310003256 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 657310003257 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 657310003258 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 657310003259 Walker A/P-loop; other site 657310003260 ATP binding site [chemical binding]; other site 657310003261 Q-loop/lid; other site 657310003262 ABC transporter signature motif; other site 657310003263 Walker B; other site 657310003264 D-loop; other site 657310003265 H-loop/switch region; other site 657310003266 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 657310003267 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 657310003268 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 657310003269 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 657310003270 ATP binding site [chemical binding]; other site 657310003271 putative Mg++ binding site [ion binding]; other site 657310003272 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 657310003273 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 657310003274 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 657310003275 substrate binding site [chemical binding]; other site 657310003276 dimer interface [polypeptide binding]; other site 657310003277 catalytic triad [active] 657310003278 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 657310003279 active site 657310003280 intersubunit interactions; other site 657310003281 catalytic residue [active] 657310003282 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 657310003283 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 657310003284 active site 657310003285 intersubunit interface [polypeptide binding]; other site 657310003286 catalytic residue [active] 657310003287 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 657310003288 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 657310003289 active site 657310003290 P-loop; other site 657310003291 phosphorylation site [posttranslational modification] 657310003292 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 657310003293 HTH domain; Region: HTH_11; pfam08279 657310003294 PRD domain; Region: PRD; pfam00874 657310003295 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 657310003296 active site 657310003297 P-loop; other site 657310003298 phosphorylation site [posttranslational modification] 657310003299 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 657310003300 active site 657310003301 phosphorylation site [posttranslational modification] 657310003302 Transposase; Region: HTH_Tnp_1; cl17663 657310003303 Transposase; Region: HTH_Tnp_1; cl17663 657310003304 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 657310003305 catalytic core [active] 657310003306 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 657310003307 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 657310003308 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 657310003309 active site 657310003310 P-loop; other site 657310003311 phosphorylation site [posttranslational modification] 657310003312 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 657310003313 active site 657310003314 phosphorylation site [posttranslational modification] 657310003315 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 657310003316 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 657310003317 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 657310003318 non-specific DNA binding site [nucleotide binding]; other site 657310003319 salt bridge; other site 657310003320 sequence-specific DNA binding site [nucleotide binding]; other site 657310003321 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 657310003322 non-specific DNA binding site [nucleotide binding]; other site 657310003323 salt bridge; other site 657310003324 sequence-specific DNA binding site [nucleotide binding]; other site 657310003325 CHC2 zinc finger; Region: zf-CHC2; cl17510 657310003326 Helix-turn-helix domain; Region: HTH_17; pfam12728 657310003327 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 657310003328 non-specific DNA binding site [nucleotide binding]; other site 657310003329 salt bridge; other site 657310003330 sequence-specific DNA binding site [nucleotide binding]; other site 657310003331 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 657310003332 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 657310003333 trimerization site [polypeptide binding]; other site 657310003334 active site 657310003335 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 657310003336 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 657310003337 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 657310003338 catalytic residue [active] 657310003339 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 657310003340 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 657310003341 FeS assembly protein SufD; Region: sufD; TIGR01981 657310003342 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 657310003343 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 657310003344 Walker A/P-loop; other site 657310003345 ATP binding site [chemical binding]; other site 657310003346 Q-loop/lid; other site 657310003347 ABC transporter signature motif; other site 657310003348 Walker B; other site 657310003349 D-loop; other site 657310003350 H-loop/switch region; other site 657310003351 ribosome recycling factor; Reviewed; Region: frr; PRK00083 657310003352 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 657310003353 hinge region; other site 657310003354 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 657310003355 putative nucleotide binding site [chemical binding]; other site 657310003356 uridine monophosphate binding site [chemical binding]; other site 657310003357 homohexameric interface [polypeptide binding]; other site 657310003358 elongation factor Ts; Provisional; Region: tsf; PRK09377 657310003359 UBA/TS-N domain; Region: UBA; pfam00627 657310003360 Elongation factor TS; Region: EF_TS; pfam00889 657310003361 Elongation factor TS; Region: EF_TS; pfam00889 657310003362 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 657310003363 rRNA interaction site [nucleotide binding]; other site 657310003364 S8 interaction site; other site 657310003365 putative laminin-1 binding site; other site 657310003366 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 657310003367 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 657310003368 Coenzyme A binding pocket [chemical binding]; other site 657310003369 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 657310003370 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 657310003371 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 657310003372 Acylphosphatases [Energy production and conversion]; Region: AcyP; COG1254 657310003373 hypothetical protein; Provisional; Region: PRK07758 657310003374 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 657310003375 DALR anticodon binding domain; Region: DALR_1; pfam05746 657310003376 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 657310003377 dimer interface [polypeptide binding]; other site 657310003378 motif 1; other site 657310003379 active site 657310003380 motif 2; other site 657310003381 motif 3; other site 657310003382 Recombination protein O N terminal; Region: RecO_N; pfam11967 657310003383 DNA repair protein RecO; Region: reco; TIGR00613 657310003384 Recombination protein O C terminal; Region: RecO_C; pfam02565 657310003385 GTPase Era; Reviewed; Region: era; PRK00089 657310003386 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 657310003387 G1 box; other site 657310003388 GTP/Mg2+ binding site [chemical binding]; other site 657310003389 Switch I region; other site 657310003390 G2 box; other site 657310003391 Switch II region; other site 657310003392 G3 box; other site 657310003393 G4 box; other site 657310003394 G5 box; other site 657310003395 KH domain; Region: KH_2; pfam07650 657310003396 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 657310003397 metal-binding heat shock protein; Provisional; Region: PRK00016 657310003398 Yqey-like protein; Region: YqeY; pfam09424 657310003399 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 657310003400 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 657310003401 metal binding site 2 [ion binding]; metal-binding site 657310003402 putative DNA binding helix; other site 657310003403 metal binding site 1 [ion binding]; metal-binding site 657310003404 dimer interface [polypeptide binding]; other site 657310003405 structural Zn2+ binding site [ion binding]; other site 657310003406 homoserine kinase; Provisional; Region: PRK01212 657310003407 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 657310003408 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 657310003409 threonine synthase; Reviewed; Region: PRK06721 657310003410 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 657310003411 homodimer interface [polypeptide binding]; other site 657310003412 pyridoxal 5'-phosphate binding site [chemical binding]; other site 657310003413 catalytic residue [active] 657310003414 homoserine dehydrogenase; Provisional; Region: PRK06349 657310003415 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 657310003416 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 657310003417 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 657310003418 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 657310003419 dimerization interface [polypeptide binding]; other site 657310003420 putative DNA binding site [nucleotide binding]; other site 657310003421 putative Zn2+ binding site [ion binding]; other site 657310003422 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 657310003423 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 657310003424 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 657310003425 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 657310003426 DNA-binding site [nucleotide binding]; DNA binding site 657310003427 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 657310003428 pyridoxal 5'-phosphate binding site [chemical binding]; other site 657310003429 homodimer interface [polypeptide binding]; other site 657310003430 catalytic residue [active] 657310003431 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 657310003432 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 657310003433 active site 657310003434 xanthine permease; Region: pbuX; TIGR03173 657310003435 Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303 657310003436 guanine deaminase; Region: guan_deamin; TIGR02967 657310003437 active site 657310003438 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 657310003439 Broad specificity phosphatase PhoE and related phosphatases [General function prediction only]; Region: phoE; COG0406 657310003440 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 657310003441 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 657310003442 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 657310003443 putative active site [active] 657310003444 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 657310003445 active site turn [active] 657310003446 phosphorylation site [posttranslational modification] 657310003447 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 657310003448 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 657310003449 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 657310003450 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 657310003451 putative active site [active] 657310003452 Uncharacterized conserved protein [Function unknown]; Region: COG3589 657310003453 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 657310003454 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 657310003455 HPr interaction site; other site 657310003456 glycerol kinase (GK) interaction site [polypeptide binding]; other site 657310003457 active site 657310003458 phosphorylation site [posttranslational modification] 657310003459 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 657310003460 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 657310003461 Phosphate transporter family; Region: PHO4; pfam01384 657310003462 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 657310003463 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 657310003464 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 657310003465 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 657310003466 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 657310003467 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 657310003468 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 657310003469 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 657310003470 catalytic motif [active] 657310003471 Zn binding site [ion binding]; other site 657310003472 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 657310003473 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 657310003474 protein binding site [polypeptide binding]; other site 657310003475 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 657310003476 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 657310003477 active site 657310003478 (T/H)XGH motif; other site 657310003479 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 657310003480 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 657310003481 S-adenosylmethionine binding site [chemical binding]; other site 657310003482 Uncharacterized protein conserved in bacteria (DUF2129); Region: DUF2129; pfam09902 657310003483 Protein of unknown function (DUF964); Region: DUF964; pfam06133 657310003484 hypothetical protein; Provisional; Region: PRK13666 657310003485 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 657310003486 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 657310003487 ATP binding site [chemical binding]; other site 657310003488 putative Mg++ binding site [ion binding]; other site 657310003489 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 657310003490 nucleotide binding region [chemical binding]; other site 657310003491 ATP-binding site [chemical binding]; other site 657310003492 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 657310003493 HRDC domain; Region: HRDC; pfam00570 657310003494 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 657310003495 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 657310003496 active site 657310003497 hypothetical protein; Provisional; Region: PRK04387 657310003498 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 657310003499 Zn2+ binding site [ion binding]; other site 657310003500 Mg2+ binding site [ion binding]; other site 657310003501 arginyl-tRNA synthetase; Reviewed; Region: PRK12451 657310003502 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 657310003503 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 657310003504 active site 657310003505 HIGH motif; other site 657310003506 KMSK motif region; other site 657310003507 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 657310003508 tRNA binding surface [nucleotide binding]; other site 657310003509 anticodon binding site; other site 657310003510 UGMP family protein; Validated; Region: PRK09604 657310003511 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 657310003512 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 657310003513 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 657310003514 Coenzyme A binding pocket [chemical binding]; other site 657310003515 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 657310003516 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 657310003517 Coenzyme A binding pocket [chemical binding]; other site 657310003518 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 657310003519 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 657310003520 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 657310003521 Membrane protease subunit, stomatin/prohibitin family [Amino acid transport and metabolism]; Region: COG4260 657310003522 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_5; cd03408 657310003523 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 657310003524 Uncharacterized protein family UPF0547; Region: UPF0547; pfam10571 657310003525 Repair protein; Region: Repair_PSII; pfam04536 657310003526 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 657310003527 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 657310003528 motif II; other site 657310003529 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 657310003530 Ligand Binding Site [chemical binding]; other site 657310003531 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 657310003532 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 657310003533 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 657310003534 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 657310003535 Walker A/P-loop; other site 657310003536 ATP binding site [chemical binding]; other site 657310003537 Q-loop/lid; other site 657310003538 ABC transporter signature motif; other site 657310003539 Walker B; other site 657310003540 D-loop; other site 657310003541 H-loop/switch region; other site 657310003542 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 657310003543 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 657310003544 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 657310003545 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 657310003546 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 657310003547 FAD binding domain; Region: FAD_binding_4; pfam01565 657310003548 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 657310003549 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 657310003550 active site 657310003551 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 657310003552 active site 657310003553 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 657310003554 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 657310003555 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 657310003556 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 657310003557 catalytic residue [active] 657310003558 putative FPP diphosphate binding site; other site 657310003559 putative FPP binding hydrophobic cleft; other site 657310003560 dimer interface [polypeptide binding]; other site 657310003561 putative IPP diphosphate binding site; other site 657310003562 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 657310003563 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 657310003564 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 657310003565 dimer interface [polypeptide binding]; other site 657310003566 conserved gate region; other site 657310003567 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 657310003568 ABC-ATPase subunit interface; other site 657310003569 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 657310003570 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 657310003571 Walker A/P-loop; other site 657310003572 ATP binding site [chemical binding]; other site 657310003573 Q-loop/lid; other site 657310003574 ABC transporter signature motif; other site 657310003575 Walker B; other site 657310003576 D-loop; other site 657310003577 H-loop/switch region; other site 657310003578 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 657310003579 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 657310003580 lipoyl attachment site [posttranslational modification]; other site 657310003581 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 657310003582 ArsC family; Region: ArsC; pfam03960 657310003583 putative ArsC-like catalytic residues; other site 657310003584 putative TRX-like catalytic residues [active] 657310003585 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 657310003586 Mga helix-turn-helix domain; Region: Mga; pfam05043 657310003587 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 657310003588 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 657310003589 Predicted membrane protein [Function unknown]; Region: COG4392 657310003590 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 657310003591 active site 657310003592 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 657310003593 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 657310003594 dimer interface [polypeptide binding]; other site 657310003595 active site 657310003596 glycine-pyridoxal phosphate binding site [chemical binding]; other site 657310003597 folate binding site [chemical binding]; other site 657310003598 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 657310003599 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 657310003600 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 657310003601 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 657310003602 S-adenosylmethionine binding site [chemical binding]; other site 657310003603 peptide chain release factor 1; Validated; Region: prfA; PRK00591 657310003604 This domain is found in peptide chain release factors; Region: PCRF; smart00937 657310003605 RF-1 domain; Region: RF-1; pfam00472 657310003606 thymidine kinase; Provisional; Region: PRK04296 657310003607 fumarate reductase flavoprotein subunit; Validated; Region: PRK06481 657310003608 L-aspartate oxidase; Provisional; Region: PRK06175 657310003609 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 657310003610 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 657310003611 dimer interface [polypeptide binding]; other site 657310003612 PYR/PP interface [polypeptide binding]; other site 657310003613 TPP binding site [chemical binding]; other site 657310003614 substrate binding site [chemical binding]; other site 657310003615 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 657310003616 Domain of unknown function; Region: EKR; smart00890 657310003617 4Fe-4S binding domain; Region: Fer4_6; pfam12837 657310003618 4Fe-4S binding domain; Region: Fer4; pfam00037 657310003619 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 657310003620 TPP-binding site [chemical binding]; other site 657310003621 dimer interface [polypeptide binding]; other site 657310003622 putative oxidoreductase; Provisional; Region: PRK12831 657310003623 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 657310003624 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 657310003625 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 657310003626 ferredoxin-NADP(+) reductase subunit alpha; Reviewed; Region: PRK06222 657310003627 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)...; Region: DHOD_e_trans_like1; cd06219 657310003628 FAD binding pocket [chemical binding]; other site 657310003629 FAD binding motif [chemical binding]; other site 657310003630 phosphate binding motif [ion binding]; other site 657310003631 beta-alpha-beta structure motif; other site 657310003632 NAD binding pocket [chemical binding]; other site 657310003633 Iron coordination center [ion binding]; other site 657310003634 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 657310003635 Protein of unknown function (DUF3343); Region: DUF3343; pfam11823 657310003636 selenium metabolism protein YedF; Region: selenium_YedF; TIGR03527 657310003637 SirA_like_N, a protein of unknown function with an N-terminal SirA-like domain. The SirA, YedF, YeeD protein family is present in bacteria as well as archaea. SirA (also known as UvrY, and YhhP) belongs to a family of a two-component response...; Region: SirA_like_N; cd03421 657310003638 CPxP motif; other site 657310003639 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 657310003640 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 657310003641 dimerization interface [polypeptide binding]; other site 657310003642 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 657310003643 cysteine desulfurase family protein; Region: am_tr_V_EF2568; TIGR01977 657310003644 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 657310003645 catalytic residue [active] 657310003646 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 657310003647 Ligand binding site; other site 657310003648 metal-binding site 657310003649 selenium-dependent molybdenum hydroxylase 1; Region: Se_dep_Molyb_1; TIGR03311 657310003650 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 657310003651 catalytic loop [active] 657310003652 iron binding site [ion binding]; other site 657310003653 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 657310003654 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 657310003655 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 657310003656 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 657310003657 XdhC Rossmann domain; Region: XdhC_C; pfam13478 657310003658 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 657310003659 xanthine permease; Region: pbuX; TIGR03173 657310003660 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 657310003661 homotrimer interaction site [polypeptide binding]; other site 657310003662 putative active site [active] 657310003663 carbamate kinase; Reviewed; Region: PRK12686 657310003664 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 657310003665 putative substrate binding site [chemical binding]; other site 657310003666 nucleotide binding site [chemical binding]; other site 657310003667 nucleotide binding site [chemical binding]; other site 657310003668 homodimer interface [polypeptide binding]; other site 657310003669 aspartate/ornithine carbamoyltransferase family protein; Validated; Region: PRK07200 657310003670 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 657310003671 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 657310003672 putative selenium metabolism hydrolase; Region: selenium_YgeY; TIGR03526 657310003673 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like4; cd05649 657310003674 putative metal binding site [ion binding]; other site 657310003675 putative dimer interface [polypeptide binding]; other site 657310003676 D-hydantoinase; Region: D-hydantoinase; TIGR02033 657310003677 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 657310003678 tetramer interface [polypeptide binding]; other site 657310003679 active site 657310003680 putative chlorohydrolase/aminohydrolase; Validated; Region: PRK07203 657310003681 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 657310003682 active site 657310003683 putative substrate binding pocket [chemical binding]; other site 657310003684 YheO-like PAS domain; Region: PAS_6; pfam08348 657310003685 HTH domain; Region: HTH_22; pfam13309 657310003686 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 657310003687 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 657310003688 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 657310003689 NH_3: A subgroup of nucleoside hydrolases. This group contains eukaryotic and bacterial proteins similar to nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes...; Region: nuc_hydro_3; cd02653 657310003690 active site 657310003691 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 657310003692 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 657310003693 Beta-lactamase; Region: Beta-lactamase; pfam00144 657310003694 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 657310003695 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 657310003696 active site 657310003697 metal binding site [ion binding]; metal-binding site 657310003698 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 657310003699 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 657310003700 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 657310003701 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 657310003702 Walker A/P-loop; other site 657310003703 ATP binding site [chemical binding]; other site 657310003704 Q-loop/lid; other site 657310003705 ABC transporter signature motif; other site 657310003706 Walker B; other site 657310003707 D-loop; other site 657310003708 H-loop/switch region; other site 657310003709 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 657310003710 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 657310003711 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 657310003712 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 657310003713 catalytic site [active] 657310003714 G-X2-G-X-G-K; other site 657310003715 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 657310003716 beta-galactosidase; Region: BGL; TIGR03356 657310003717 transcriptional antiterminator BglG; Provisional; Region: PRK09772 657310003718 CAT RNA binding domain; Region: CAT_RBD; smart01061 657310003719 PRD domain; Region: PRD; pfam00874 657310003720 PRD domain; Region: PRD; pfam00874 657310003721 Acyl carrier protein phosphodiesterase [Lipid metabolism]; Region: AcpD; COG1182 657310003722 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 657310003723 Domain of unknown function DUF20; Region: UPF0118; pfam01594 657310003724 PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; cl01516 657310003725 DNA-directed RNA polymerase subunit beta; Region: EpuA; pfam11772 657310003726 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 657310003727 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 657310003728 hinge; other site 657310003729 active site 657310003730 conserved hypothetical integral membrane protein; Region: int_mem_ywzB; TIGR02327 657310003731 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 657310003732 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 657310003733 gamma subunit interface [polypeptide binding]; other site 657310003734 epsilon subunit interface [polypeptide binding]; other site 657310003735 LBP interface [polypeptide binding]; other site 657310003736 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 657310003737 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 657310003738 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 657310003739 alpha subunit interaction interface [polypeptide binding]; other site 657310003740 Walker A motif; other site 657310003741 ATP binding site [chemical binding]; other site 657310003742 Walker B motif; other site 657310003743 inhibitor binding site; inhibition site 657310003744 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 657310003745 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 657310003746 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 657310003747 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 657310003748 beta subunit interaction interface [polypeptide binding]; other site 657310003749 Walker A motif; other site 657310003750 ATP binding site [chemical binding]; other site 657310003751 Walker B motif; other site 657310003752 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 657310003753 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 657310003754 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 657310003755 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 657310003756 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 657310003757 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 657310003758 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 657310003759 SmpB-tmRNA interface; other site 657310003760 ribonuclease R; Region: RNase_R; TIGR02063 657310003761 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 657310003762 RNB domain; Region: RNB; pfam00773 657310003763 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 657310003764 RNA binding site [nucleotide binding]; other site 657310003765 Preprotein translocase SecG subunit; Region: SecG; pfam03840 657310003766 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 657310003767 Coenzyme A binding pocket [chemical binding]; other site 657310003768 Uncharacterized conserved protein [Function unknown]; Region: COG3592 657310003769 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 657310003770 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 657310003771 Soluble P-type ATPase [General function prediction only]; Region: COG4087 657310003772 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 657310003773 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 657310003774 homodimer interface [polypeptide binding]; other site 657310003775 NAD binding pocket [chemical binding]; other site 657310003776 ATP binding pocket [chemical binding]; other site 657310003777 Mg binding site [ion binding]; other site 657310003778 active-site loop [active] 657310003779 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 657310003780 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 657310003781 active site 657310003782 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 657310003783 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 657310003784 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 657310003785 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 657310003786 ribonuclease Y; Region: RNase_Y; TIGR03319 657310003787 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 657310003788 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 657310003789 DNA binding site [nucleotide binding] 657310003790 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 657310003791 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 657310003792 ring oligomerisation interface [polypeptide binding]; other site 657310003793 ATP/Mg binding site [chemical binding]; other site 657310003794 stacking interactions; other site 657310003795 hinge regions; other site 657310003796 CAAX protease self-immunity; Region: Abi; pfam02517 657310003797 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 657310003798 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 657310003799 Walker A/P-loop; other site 657310003800 ATP binding site [chemical binding]; other site 657310003801 Q-loop/lid; other site 657310003802 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 657310003803 ABC transporter signature motif; other site 657310003804 Walker B; other site 657310003805 D-loop; other site 657310003806 H-loop/switch region; other site 657310003807 ABC transporter; Region: ABC_tran_2; pfam12848 657310003808 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 657310003809 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 657310003810 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 657310003811 DNA-binding site [nucleotide binding]; DNA binding site 657310003812 TrkA-C domain; Region: TrkA_C; pfam02080 657310003813 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 657310003814 dimer interface [polypeptide binding]; other site 657310003815 conserved gate region; other site 657310003816 putative PBP binding loops; other site 657310003817 ABC-ATPase subunit interface; other site 657310003818 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 657310003819 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 657310003820 Uncharacterized protein/domain associated with GTPases [Function unknown]; Region: COG3597 657310003821 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 657310003822 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 657310003823 glycerate kinase; Region: TIGR00045 657310003824 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 657310003825 fructuronate transporter; Provisional; Region: PRK10034; cl15264 657310003826 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 657310003827 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 657310003828 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 657310003829 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 657310003830 dimer interface [polypeptide binding]; other site 657310003831 conserved gate region; other site 657310003832 putative PBP binding loops; other site 657310003833 ABC-ATPase subunit interface; other site 657310003834 2-aminoethylphosphonate transport system permease PhnU; Provisional; Region: PRK15050 657310003835 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 657310003836 dimer interface [polypeptide binding]; other site 657310003837 conserved gate region; other site 657310003838 putative PBP binding loops; other site 657310003839 ABC-ATPase subunit interface; other site 657310003840 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 657310003841 non-specific DNA binding site [nucleotide binding]; other site 657310003842 salt bridge; other site 657310003843 sequence-specific DNA binding site [nucleotide binding]; other site 657310003844 Cupin domain; Region: Cupin_2; pfam07883 657310003845 Yhdh and yhfp-like putative quinone oxidoreductases; Region: MDR_yhdh_yhfp; cd05280 657310003846 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 657310003847 NADP binding site [chemical binding]; other site 657310003848 dimer interface [polypeptide binding]; other site 657310003849 DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410 657310003850 phosphopantothenoylcysteine decarboxylase, streptococcal; Region: coaC_strep; TIGR02113 657310003851 Flavoprotein; Region: Flavoprotein; pfam02441 657310003852 QueT transporter; Region: QueT; pfam06177 657310003853 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 657310003854 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 657310003855 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 657310003856 catalytic core [active] 657310003857 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 657310003858 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 657310003859 S-adenosylmethionine binding site [chemical binding]; other site 657310003860 Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142 657310003861 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 657310003862 MgtE intracellular N domain; Region: MgtE_N; pfam03448 657310003863 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 657310003864 Divalent cation transporter; Region: MgtE; pfam01769 657310003865 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 657310003866 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 657310003867 active site 657310003868 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 657310003869 ATP-NAD kinase; Region: NAD_kinase; pfam01513 657310003870 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 657310003871 synthetase active site [active] 657310003872 NTP binding site [chemical binding]; other site 657310003873 metal binding site [ion binding]; metal-binding site 657310003874 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 657310003875 putative active site [active] 657310003876 putative metal binding residues [ion binding]; other site 657310003877 signature motif; other site 657310003878 putative triphosphate binding site [ion binding]; other site 657310003879 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 657310003880 catalytic residues [active] 657310003881 Oligoendopeptidase F [Amino acid transport and metabolism]; Region: COG1164 657310003882 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 657310003883 active site 657310003884 Zn binding site [ion binding]; other site 657310003885 Competence protein CoiA-like family; Region: CoiA; pfam06054 657310003886 adaptor protein; Provisional; Region: PRK02315 657310003887 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 657310003888 ArsC family; Region: ArsC; pfam03960 657310003889 putative catalytic residues [active] 657310003890 thiol/disulfide switch; other site 657310003891 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 657310003892 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 657310003893 active site 657310003894 HIGH motif; other site 657310003895 dimer interface [polypeptide binding]; other site 657310003896 KMSKS motif; other site 657310003897 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 657310003898 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 657310003899 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 657310003900 Walker A/P-loop; other site 657310003901 ATP binding site [chemical binding]; other site 657310003902 Q-loop/lid; other site 657310003903 ABC transporter signature motif; other site 657310003904 Walker B; other site 657310003905 D-loop; other site 657310003906 H-loop/switch region; other site 657310003907 WxL domain surface cell wall-binding; Region: WxL; pfam13731 657310003908 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 657310003909 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 657310003910 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 657310003911 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 657310003912 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 657310003913 LRR adjacent; Region: LRR_adjacent; pfam08191 657310003914 WxL domain surface cell wall-binding; Region: WxL; pfam13731 657310003915 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 657310003916 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 657310003917 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 657310003918 ATP binding site [chemical binding]; other site 657310003919 putative Mg++ binding site [ion binding]; other site 657310003920 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 657310003921 nucleotide binding region [chemical binding]; other site 657310003922 ATP-binding site [chemical binding]; other site 657310003923 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 657310003924 AAA domain; Region: AAA_23; pfam13476 657310003925 Walker A/P-loop; other site 657310003926 ATP binding site [chemical binding]; other site 657310003927 Q-loop/lid; other site 657310003928 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 657310003929 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 657310003930 ABC transporter signature motif; other site 657310003931 Walker B; other site 657310003932 D-loop; other site 657310003933 H-loop/switch region; other site 657310003934 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 657310003935 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 657310003936 active site 657310003937 metal binding site [ion binding]; metal-binding site 657310003938 DNA binding site [nucleotide binding] 657310003939 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 657310003940 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 657310003941 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 657310003942 putative acyl-acceptor binding pocket; other site 657310003943 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 657310003944 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 657310003945 S-adenosylmethionine binding site [chemical binding]; other site 657310003946 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 657310003947 GIY-YIG motif/motif A; other site 657310003948 putative active site [active] 657310003949 putative metal binding site [ion binding]; other site 657310003950 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 657310003951 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 657310003952 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 657310003953 dimer interface [polypeptide binding]; other site 657310003954 ADP-ribose binding site [chemical binding]; other site 657310003955 active site 657310003956 nudix motif; other site 657310003957 metal binding site [ion binding]; metal-binding site 657310003958 5-bromo-4-chloroindolyl phosphate hydrolysis protein; Region: Halogen_Hydrol; pfam10112 657310003959 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 657310003960 Transcriptional regulator [Transcription]; Region: LytR; COG1316 657310003961 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 657310003962 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 657310003963 minor groove reading motif; other site 657310003964 helix-hairpin-helix signature motif; other site 657310003965 substrate binding pocket [chemical binding]; other site 657310003966 active site 657310003967 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 657310003968 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 657310003969 DNA binding and oxoG recognition site [nucleotide binding] 657310003970 recombination regulator RecX; Provisional; Region: recX; PRK14135 657310003971 TRAM domain; Region: TRAM; pfam01938 657310003972 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 657310003973 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 657310003974 S-adenosylmethionine binding site [chemical binding]; other site 657310003975 Predicted membrane protein [Function unknown]; Region: COG2261 657310003976 Amino acid permease; Region: AA_permease_2; pfam13520 657310003977 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 657310003978 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 657310003979 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 657310003980 Glucosyl transferase GtrII; Region: Glucos_trans_II; pfam14264 657310003981 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 657310003982 core dimer interface [polypeptide binding]; other site 657310003983 peripheral dimer interface [polypeptide binding]; other site 657310003984 L10 interface [polypeptide binding]; other site 657310003985 L11 interface [polypeptide binding]; other site 657310003986 putative EF-Tu interaction site [polypeptide binding]; other site 657310003987 putative EF-G interaction site [polypeptide binding]; other site 657310003988 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 657310003989 23S rRNA interface [nucleotide binding]; other site 657310003990 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 657310003991 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 657310003992 mRNA/rRNA interface [nucleotide binding]; other site 657310003993 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 657310003994 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 657310003995 ABC transporter; Region: ABC_tran_2; pfam12848 657310003996 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 657310003997 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 657310003998 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 657310003999 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 657310004000 putative L-serine binding site [chemical binding]; other site 657310004001 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 657310004002 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 657310004003 Peptidase M55, D-aminopeptidase dipeptide-binding protein family; Region: DAP_dppA_2; cd08769 657310004004 SxDxEG motif; other site 657310004005 putative active site [active] 657310004006 putative metal binding site [ion binding]; other site 657310004007 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 657310004008 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 657310004009 oligomer interface [polypeptide binding]; other site 657310004010 active site 657310004011 metal binding site [ion binding]; metal-binding site 657310004012 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 657310004013 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 657310004014 peptide binding site [polypeptide binding]; other site 657310004015 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 657310004016 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 657310004017 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 657310004018 putative active site [active] 657310004019 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 657310004020 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 657310004021 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 657310004022 putative homodimer interface [polypeptide binding]; other site 657310004023 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 657310004024 heterodimer interface [polypeptide binding]; other site 657310004025 homodimer interface [polypeptide binding]; other site 657310004026 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 657310004027 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 657310004028 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 657310004029 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 657310004030 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 657310004031 active site 657310004032 putative catalytic site [active] 657310004033 DNA binding site [nucleotide binding] 657310004034 putative phosphate binding site [ion binding]; other site 657310004035 metal binding site A [ion binding]; metal-binding site 657310004036 AP binding site [nucleotide binding]; other site 657310004037 metal binding site B [ion binding]; metal-binding site 657310004038 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 657310004039 active site 657310004040 catalytic site [active] 657310004041 substrate binding site [chemical binding]; other site 657310004042 peroxiredoxin; Region: AhpC; TIGR03137 657310004043 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 657310004044 dimer interface [polypeptide binding]; other site 657310004045 decamer (pentamer of dimers) interface [polypeptide binding]; other site 657310004046 catalytic triad [active] 657310004047 peroxidatic and resolving cysteines [active] 657310004048 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 657310004049 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 657310004050 S-adenosylmethionine binding site [chemical binding]; other site 657310004051 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 657310004052 putative hydrolase; Provisional; Region: PRK02113 657310004053 Protein of unknown function (DUF975); Region: DUF975; cl10504 657310004054 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 657310004055 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 657310004056 oligomer interface [polypeptide binding]; other site 657310004057 active site 657310004058 metal binding site [ion binding]; metal-binding site 657310004059 D-alanyl-lipoteichoic acid biosynthesis protein DltD; Region: LTA_DltD; TIGR04092 657310004060 DltD N-terminal region; Region: DltD_N; pfam04915 657310004061 DltD central region; Region: DltD_M; pfam04918 657310004062 DltD C-terminal region; Region: DltD_C; pfam04914 657310004063 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087 657310004064 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091 657310004065 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 657310004066 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 657310004067 acyl-activating enzyme (AAE) consensus motif; other site 657310004068 AMP binding site [chemical binding]; other site 657310004069 D-Ala-teichoic acid biosynthesis protein; Region: DUF3687; pfam12459 657310004070 FtsX-like permease family; Region: FtsX; pfam02687 657310004071 FtsX-like permease family; Region: FtsX; pfam02687 657310004072 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 657310004073 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 657310004074 Walker A/P-loop; other site 657310004075 ATP binding site [chemical binding]; other site 657310004076 Q-loop/lid; other site 657310004077 ABC transporter signature motif; other site 657310004078 Walker B; other site 657310004079 D-loop; other site 657310004080 H-loop/switch region; other site 657310004081 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804 657310004082 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 657310004083 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 657310004084 active site 657310004085 DNA polymerase IV; Validated; Region: PRK02406 657310004086 DNA binding site [nucleotide binding] 657310004087 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 657310004088 Predicted methyltransferases [General function prediction only]; Region: COG0313 657310004089 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 657310004090 putative SAM binding site [chemical binding]; other site 657310004091 putative homodimer interface [polypeptide binding]; other site 657310004092 Protein of unknown function (DUF972); Region: DUF972; pfam06156 657310004093 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 657310004094 DNA polymerase III subunit delta'; Validated; Region: PRK08058 657310004095 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 657310004096 Walker A motif; other site 657310004097 ATP binding site [chemical binding]; other site 657310004098 Walker B motif; other site 657310004099 arginine finger; other site 657310004100 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3870 657310004101 recombination protein RecR; Reviewed; Region: recR; PRK00076 657310004102 RecR protein; Region: RecR; pfam02132 657310004103 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 657310004104 putative active site [active] 657310004105 putative metal-binding site [ion binding]; other site 657310004106 tetramer interface [polypeptide binding]; other site 657310004107 Putative transcription activator [Transcription]; Region: TenA; COG0819 657310004108 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 657310004109 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 657310004110 Walker A/P-loop; other site 657310004111 ATP binding site [chemical binding]; other site 657310004112 Q-loop/lid; other site 657310004113 ABC transporter signature motif; other site 657310004114 Walker B; other site 657310004115 D-loop; other site 657310004116 H-loop/switch region; other site 657310004117 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4136 657310004118 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 657310004119 Walker A/P-loop; other site 657310004120 ATP binding site [chemical binding]; other site 657310004121 Q-loop/lid; other site 657310004122 ABC transporter signature motif; other site 657310004123 Walker B; other site 657310004124 D-loop; other site 657310004125 H-loop/switch region; other site 657310004126 TraX protein; Region: TraX; cl05434 657310004127 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 657310004128 putative substrate translocation pore; other site 657310004129 Major Facilitator Superfamily; Region: MFS_1; pfam07690 657310004130 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 657310004131 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 657310004132 putative substrate translocation pore; other site 657310004133 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 657310004134 dimer interface [polypeptide binding]; other site 657310004135 substrate binding site [chemical binding]; other site 657310004136 ATP binding site [chemical binding]; other site 657310004137 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 657310004138 thiamine phosphate binding site [chemical binding]; other site 657310004139 active site 657310004140 pyrophosphate binding site [ion binding]; other site 657310004141 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 657310004142 substrate binding site [chemical binding]; other site 657310004143 multimerization interface [polypeptide binding]; other site 657310004144 ATP binding site [chemical binding]; other site 657310004145 hypothetical protein; Validated; Region: PRK00153 657310004146 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 657310004147 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 657310004148 Walker A motif; other site 657310004149 ATP binding site [chemical binding]; other site 657310004150 Walker B motif; other site 657310004151 arginine finger; other site 657310004152 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 657310004153 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 657310004154 Protein of unknown function (DUF3042); Region: DUF3042; pfam11240 657310004155 Uncharacterized conserved protein [Function unknown]; Region: COG3189 657310004156 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 657310004157 active site residue [active] 657310004158 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 657310004159 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 657310004160 nucleotide binding site [chemical binding]; other site 657310004161 Bacterial protein of unknown function (DUF910); Region: DUF910; pfam06014 657310004162 Rhomboid family; Region: Rhomboid; pfam01694 657310004163 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 657310004164 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 657310004165 esterase; Provisional; Region: PRK10566 657310004166 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 657310004167 conserved hypothetical integral membrane protein; Region: TIGR03766 657310004168 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 657310004169 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 657310004170 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 657310004171 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 657310004172 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 657310004173 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 657310004174 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 657310004175 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 657310004176 active site 657310004177 dimer interface [polypeptide binding]; other site 657310004178 motif 1; other site 657310004179 motif 2; other site 657310004180 motif 3; other site 657310004181 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 657310004182 anticodon binding site; other site 657310004183 4-oxalocrotonate tautomerase; Provisional; Region: PRK02220 657310004184 active site 1 [active] 657310004185 dimer interface [polypeptide binding]; other site 657310004186 hexamer interface [polypeptide binding]; other site 657310004187 active site 2 [active] 657310004188 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 657310004189 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 657310004190 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 657310004191 active site 657310004192 phosphorylation site [posttranslational modification] 657310004193 intermolecular recognition site; other site 657310004194 dimerization interface [polypeptide binding]; other site 657310004195 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 657310004196 DNA binding site [nucleotide binding] 657310004197 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 657310004198 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 657310004199 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 657310004200 Streptomycin adenylyltransferase; Region: Adenyl_transf; pfam04439 657310004201 Uncharacterized conserved protein [Function unknown]; Region: COG1434 657310004202 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 657310004203 putative active site [active] 657310004204 Endo-beta-N-acetylglucosaminidases are bacterial chitinases that hydrolyze the chitin core of various asparagine (N)-linked glycans and glycoproteins. The endo-beta-N-acetylglucosaminidases have a glycosyl hydrolase family 18 (GH18) catalytic domain; Region: GH18_EndoS-like; cd06542 657310004205 active site 657310004206 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 657310004207 hypothetical protein; Provisional; Region: PRK12378 657310004208 Methyltransferase domain; Region: Methyltransf_23; pfam13489 657310004209 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 657310004210 S-adenosylmethionine binding site [chemical binding]; other site 657310004211 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 657310004212 Zn2+ binding site [ion binding]; other site 657310004213 Mg2+ binding site [ion binding]; other site 657310004214 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 657310004215 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 657310004216 active site 657310004217 (T/H)XGH motif; other site 657310004218 GTPase YqeH; Provisional; Region: PRK13796 657310004219 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 657310004220 GTP/Mg2+ binding site [chemical binding]; other site 657310004221 G4 box; other site 657310004222 G5 box; other site 657310004223 G1 box; other site 657310004224 Switch I region; other site 657310004225 G2 box; other site 657310004226 G3 box; other site 657310004227 Switch II region; other site 657310004228 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 657310004229 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 657310004230 active site 657310004231 motif I; other site 657310004232 motif II; other site 657310004233 acetyl-CoA carboxylase subunit alpha; Provisional; Region: PRK12319 657310004234 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 657310004235 Uncharacterized protein family UPF0547; Region: UPF0547; pfam10571 657310004236 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 657310004237 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 657310004238 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 657310004239 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 657310004240 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 657310004241 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 657310004242 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 657310004243 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 657310004244 carboxyltransferase (CT) interaction site; other site 657310004245 biotinylation site [posttranslational modification]; other site 657310004246 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 657310004247 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 657310004248 dimer interface [polypeptide binding]; other site 657310004249 active site 657310004250 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 657310004251 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 657310004252 NAD(P) binding site [chemical binding]; other site 657310004253 homotetramer interface [polypeptide binding]; other site 657310004254 homodimer interface [polypeptide binding]; other site 657310004255 active site 657310004256 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 657310004257 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 657310004258 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 657310004259 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 657310004260 FMN binding site [chemical binding]; other site 657310004261 substrate binding site [chemical binding]; other site 657310004262 putative catalytic residue [active] 657310004263 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 657310004264 acyl carrier protein; Provisional; Region: acpP; PRK00982 657310004265 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 657310004266 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 657310004267 dimer interface [polypeptide binding]; other site 657310004268 active site 657310004269 CoA binding pocket [chemical binding]; other site 657310004270 Transcriptional regulators [Transcription]; Region: MarR; COG1846 657310004271 MarR family; Region: MarR_2; pfam12802 657310004272 Protein of unknown function (DUF1797); Region: DUF1797; pfam08796 657310004273 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 657310004274 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 657310004275 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 657310004276 substrate binding site [chemical binding]; other site 657310004277 Phage uncharacterized protein (Phage_XkdX); Region: Phage_XkdX; pfam09693 657310004278 Phage tail protein; Region: Sipho_tail; cl17486 657310004279 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 657310004280 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 657310004281 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 657310004282 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 657310004283 Phage terminase large subunit; Region: Terminase_3; cl12054 657310004284 Terminase-like family; Region: Terminase_6; pfam03237 657310004285 Terminase small subunit; Region: Terminase_2; pfam03592 657310004286 Predicted permease [General function prediction only]; Region: COG2056 657310004287 YopX protein; Region: YopX; pfam09643 657310004288 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 657310004289 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 657310004290 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 657310004291 S-adenosylmethionine binding site [chemical binding]; other site 657310004292 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 657310004293 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 657310004294 dimer interface [polypeptide binding]; other site 657310004295 ssDNA binding site [nucleotide binding]; other site 657310004296 tetramer (dimer of dimers) interface [polypeptide binding]; other site 657310004297 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u3; cd11540 657310004298 putative metal binding site [ion binding]; other site 657310004299 Protein of unknown function (DUF1351); Region: DUF1351; pfam07083 657310004300 ERF superfamily; Region: ERF; pfam04404 657310004301 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 657310004302 ORF6C domain; Region: ORF6C; pfam10552 657310004303 Domain of unknown function (DUF771); Region: DUF771; pfam05595 657310004304 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 657310004305 non-specific DNA binding site [nucleotide binding]; other site 657310004306 salt bridge; other site 657310004307 sequence-specific DNA binding site [nucleotide binding]; other site 657310004308 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 657310004309 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 657310004310 non-specific DNA binding site [nucleotide binding]; other site 657310004311 salt bridge; other site 657310004312 sequence-specific DNA binding site [nucleotide binding]; other site 657310004313 Domain of unknown function (DUF955); Region: DUF955; pfam06114 657310004314 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107 657310004315 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 657310004316 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 657310004317 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 657310004318 Int/Topo IB signature motif; other site 657310004319 Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527 657310004320 Sterol carrier protein domain; Region: SCP2_2; pfam13530 657310004321 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 657310004322 beta-galactosidase; Region: BGL; TIGR03356 657310004323 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 657310004324 active site 657310004325 methionine cluster; other site 657310004326 phosphorylation site [posttranslational modification] 657310004327 metal binding site [ion binding]; metal-binding site 657310004328 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 657310004329 active site 657310004330 P-loop; other site 657310004331 phosphorylation site [posttranslational modification] 657310004332 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 657310004333 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 657310004334 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 657310004335 active site 657310004336 P-loop; other site 657310004337 phosphorylation site [posttranslational modification] 657310004338 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 657310004339 putative Zn2+ binding site [ion binding]; other site 657310004340 putative DNA binding site [nucleotide binding]; other site 657310004341 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 657310004342 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 657310004343 Walker A motif; other site 657310004344 ATP binding site [chemical binding]; other site 657310004345 Walker B motif; other site 657310004346 arginine finger; other site 657310004347 Transcriptional antiterminator [Transcription]; Region: COG3933 657310004348 PRD domain; Region: PRD; pfam00874 657310004349 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 657310004350 active pocket/dimerization site; other site 657310004351 active site 657310004352 phosphorylation site [posttranslational modification] 657310004353 PRD domain; Region: PRD; pfam00874 657310004354 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 657310004355 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 657310004356 ATP binding site [chemical binding]; other site 657310004357 putative Mg++ binding site [ion binding]; other site 657310004358 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 657310004359 nucleotide binding region [chemical binding]; other site 657310004360 ATP-binding site [chemical binding]; other site 657310004361 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 657310004362 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 657310004363 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 657310004364 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 657310004365 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 657310004366 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 657310004367 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 657310004368 FeoA domain; Region: FeoA; pfam04023 657310004369 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 657310004370 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 657310004371 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 657310004372 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 657310004373 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 657310004374 active site 657310004375 HIGH motif; other site 657310004376 nucleotide binding site [chemical binding]; other site 657310004377 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 657310004378 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 657310004379 active site 657310004380 KMSKS motif; other site 657310004381 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 657310004382 tRNA binding surface [nucleotide binding]; other site 657310004383 anticodon binding site; other site 657310004384 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 657310004385 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 657310004386 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 657310004387 RNA binding surface [nucleotide binding]; other site 657310004388 Protein of unknown function (DUF552); Region: DUF552; pfam04472 657310004389 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 657310004390 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 657310004391 catalytic residue [active] 657310004392 cell division protein FtsZ; Validated; Region: PRK09330 657310004393 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 657310004394 nucleotide binding site [chemical binding]; other site 657310004395 SulA interaction site; other site 657310004396 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 657310004397 Cell division protein FtsA; Region: FtsA; smart00842 657310004398 Cell division protein FtsA; Region: FtsA; pfam14450 657310004399 Domain of unknown function (DUF3484); Region: DUF3484; pfam11983 657310004400 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 657310004401 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 657310004402 active site 657310004403 homodimer interface [polypeptide binding]; other site 657310004404 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 657310004405 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002 657310004406 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 657310004407 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 657310004408 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 657310004409 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 657310004410 Mg++ binding site [ion binding]; other site 657310004411 putative catalytic motif [active] 657310004412 putative substrate binding site [chemical binding]; other site 657310004413 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 657310004414 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 657310004415 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 657310004416 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 657310004417 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 657310004418 Cell division protein FtsL; Region: FtsL; cl11433 657310004419 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001 657310004420 MraZ protein; Region: MraZ; pfam02381 657310004421 MraZ protein; Region: MraZ; pfam02381 657310004422 Protein of unknown function (DUF3397); Region: DUF3397; pfam11877 657310004423 Protein of unknown function (DUF4044); Region: DUF4044; pfam13253 657310004424 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 657310004425 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 657310004426 Walker A/P-loop; other site 657310004427 ATP binding site [chemical binding]; other site 657310004428 Q-loop/lid; other site 657310004429 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 657310004430 ABC transporter signature motif; other site 657310004431 Walker B; other site 657310004432 D-loop; other site 657310004433 H-loop/switch region; other site 657310004434 Arginine repressor [Transcription]; Region: ArgR; COG1438 657310004435 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 657310004436 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 657310004437 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 657310004438 active site 657310004439 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 657310004440 S4 RNA-binding domain; Region: S4; smart00363 657310004441 RNA binding surface [nucleotide binding]; other site 657310004442 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 657310004443 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 657310004444 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 657310004445 substrate binding pocket [chemical binding]; other site 657310004446 chain length determination region; other site 657310004447 substrate-Mg2+ binding site; other site 657310004448 catalytic residues [active] 657310004449 aspartate-rich region 1; other site 657310004450 active site lid residues [active] 657310004451 aspartate-rich region 2; other site 657310004452 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 657310004453 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 657310004454 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 657310004455 generic binding surface II; other site 657310004456 generic binding surface I; other site 657310004457 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14179 657310004458 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 657310004459 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 657310004460 homodimer interface [polypeptide binding]; other site 657310004461 NADP binding site [chemical binding]; other site 657310004462 substrate binding site [chemical binding]; other site 657310004463 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 657310004464 putative RNA binding site [nucleotide binding]; other site 657310004465 Asp23 family; Region: Asp23; pfam03780 657310004466 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cd11523 657310004467 metal binding site [ion binding]; metal-binding site 657310004468 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 657310004469 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 657310004470 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 657310004471 active site 657310004472 phosphodiesterase YaeI; Provisional; Region: PRK11340 657310004473 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 657310004474 putative active site [active] 657310004475 putative metal binding site [ion binding]; other site 657310004476 phosphate-starvation-inducible protein PsiE; Provisional; Region: PRK02833 657310004477 Protein of unknown function (DUF464); Region: DUF464; pfam04327 657310004478 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 657310004479 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 657310004480 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 657310004481 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 657310004482 DNA binding residues [nucleotide binding] 657310004483 drug binding residues [chemical binding]; other site 657310004484 dimer interface [polypeptide binding]; other site 657310004485 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 657310004486 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 657310004487 putative dimer interface [polypeptide binding]; other site 657310004488 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537 657310004489 homodimer interface [polypeptide binding]; other site 657310004490 chemical substrate binding site [chemical binding]; other site 657310004491 oligomer interface [polypeptide binding]; other site 657310004492 metal binding site [ion binding]; metal-binding site 657310004493 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 657310004494 pyrroline-5-carboxylate reductase; Region: proC; TIGR00112 657310004495 Streptococcus agalactiae RgfB, part of a putative two component signal transduction system, and related proteins; Region: RgfB-like; cd09079 657310004496 putative catalytic site [active] 657310004497 putative metal binding site [ion binding]; other site 657310004498 putative phosphate binding site [ion binding]; other site 657310004499 PTS system, IIBC component; Region: PTS-II-BC-unk1; TIGR02003 657310004500 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 657310004501 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 657310004502 active site turn [active] 657310004503 phosphorylation site [posttranslational modification] 657310004504 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 657310004505 HPr interaction site; other site 657310004506 glycerol kinase (GK) interaction site [polypeptide binding]; other site 657310004507 active site 657310004508 phosphorylation site [posttranslational modification] 657310004509 maltose phosphorylase; Provisional; Region: PRK13807 657310004510 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 657310004511 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 657310004512 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 657310004513 beta-phosphoglucomutase; Region: bPGM; TIGR01990 657310004514 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 657310004515 motif II; other site 657310004516 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 657310004517 active site 657310004518 catalytic residues [active] 657310004519 Transcriptional regulators [Transcription]; Region: PurR; COG1609 657310004520 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 657310004521 DNA binding site [nucleotide binding] 657310004522 domain linker motif; other site 657310004523 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 657310004524 putative dimerization interface [polypeptide binding]; other site 657310004525 putative ligand binding site [chemical binding]; other site 657310004526 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 657310004527 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 657310004528 Coenzyme A binding pocket [chemical binding]; other site 657310004529 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 657310004530 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 657310004531 ligand binding site [chemical binding]; other site 657310004532 active site 657310004533 UGI interface [polypeptide binding]; other site 657310004534 catalytic site [active] 657310004535 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 657310004536 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 657310004537 active site 657310004538 motif I; other site 657310004539 motif II; other site 657310004540 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 657310004541 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 657310004542 Coenzyme A binding pocket [chemical binding]; other site 657310004543 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 657310004544 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 657310004545 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 657310004546 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 657310004547 Walker A/P-loop; other site 657310004548 ATP binding site [chemical binding]; other site 657310004549 Q-loop/lid; other site 657310004550 ABC transporter signature motif; other site 657310004551 Walker B; other site 657310004552 D-loop; other site 657310004553 H-loop/switch region; other site 657310004554 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 657310004555 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 657310004556 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 657310004557 Walker A/P-loop; other site 657310004558 ATP binding site [chemical binding]; other site 657310004559 Q-loop/lid; other site 657310004560 ABC transporter signature motif; other site 657310004561 Walker B; other site 657310004562 D-loop; other site 657310004563 H-loop/switch region; other site 657310004564 hypothetical protein; Provisional; Region: PRK09609 657310004565 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 657310004566 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 657310004567 active site 657310004568 dimer interfaces [polypeptide binding]; other site 657310004569 catalytic residues [active] 657310004570 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 657310004571 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 657310004572 Walker A/P-loop; other site 657310004573 ATP binding site [chemical binding]; other site 657310004574 Q-loop/lid; other site 657310004575 ABC transporter signature motif; other site 657310004576 Walker B; other site 657310004577 D-loop; other site 657310004578 H-loop/switch region; other site 657310004579 TOBE domain; Region: TOBE_2; pfam08402 657310004580 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 657310004581 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 657310004582 putative active site [active] 657310004583 putative metal binding site [ion binding]; other site 657310004584 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 657310004585 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 657310004586 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 657310004587 active site 657310004588 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 657310004589 Part of AAA domain; Region: AAA_19; pfam13245 657310004590 Family description; Region: UvrD_C_2; pfam13538 657310004591 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 657310004592 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 657310004593 active site 657310004594 HIGH motif; other site 657310004595 KMSKS motif; other site 657310004596 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 657310004597 tRNA binding surface [nucleotide binding]; other site 657310004598 anticodon binding site; other site 657310004599 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 657310004600 dimer interface [polypeptide binding]; other site 657310004601 putative tRNA-binding site [nucleotide binding]; other site 657310004602 amino acid transporter; Region: 2A0306; TIGR00909 657310004603 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 657310004604 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 657310004605 L-rhamnose-proton symport protein (RhaT); Region: RhaT; cl05728 657310004606 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 657310004607 dimer interface [polypeptide binding]; other site 657310004608 His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388 657310004609 phosphorylation site [posttranslational modification] 657310004610 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 657310004611 ATP binding site [chemical binding]; other site 657310004612 Mg2+ binding site [ion binding]; other site 657310004613 G-X-G motif; other site 657310004614 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 657310004615 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 657310004616 active site 657310004617 phosphorylation site [posttranslational modification] 657310004618 intermolecular recognition site; other site 657310004619 dimerization interface [polypeptide binding]; other site 657310004620 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 657310004621 DNA binding site [nucleotide binding] 657310004622 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 657310004623 dimer interface [polypeptide binding]; other site 657310004624 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 657310004625 dimer interface [polypeptide binding]; other site 657310004626 Transcriptional regulator [Transcription]; Region: LysR; COG0583 657310004627 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 657310004628 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 657310004629 dimerization interface [polypeptide binding]; other site 657310004630 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 657310004631 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 657310004632 Sulfate transporter family; Region: Sulfate_transp; pfam00916 657310004633 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 657310004634 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 657310004635 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 657310004636 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 657310004637 Protein of unknown function (DUF419); Region: DUF419; pfam04237 657310004638 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 657310004639 23S rRNA binding site [nucleotide binding]; other site 657310004640 L21 binding site [polypeptide binding]; other site 657310004641 L13 binding site [polypeptide binding]; other site 657310004642 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 657310004643 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 657310004644 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 657310004645 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 657310004646 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 657310004647 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 657310004648 Probable transposase; Region: OrfB_IS605; pfam01385 657310004649 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 657310004650 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 657310004651 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 657310004652 Walker A/P-loop; other site 657310004653 ATP binding site [chemical binding]; other site 657310004654 Q-loop/lid; other site 657310004655 ABC transporter signature motif; other site 657310004656 Walker B; other site 657310004657 D-loop; other site 657310004658 H-loop/switch region; other site 657310004659 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 657310004660 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 657310004661 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 657310004662 Walker A/P-loop; other site 657310004663 ATP binding site [chemical binding]; other site 657310004664 Q-loop/lid; other site 657310004665 ABC transporter signature motif; other site 657310004666 Walker B; other site 657310004667 D-loop; other site 657310004668 H-loop/switch region; other site 657310004669 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 657310004670 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 657310004671 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 657310004672 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 657310004673 dimer interface [polypeptide binding]; other site 657310004674 conserved gate region; other site 657310004675 putative PBP binding loops; other site 657310004676 ABC-ATPase subunit interface; other site 657310004677 Domain of unknown function (DUF3899); Region: DUF3899; pfam13038 657310004678 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 657310004679 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 657310004680 peptide binding site [polypeptide binding]; other site 657310004681 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 657310004682 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 657310004683 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 657310004684 mevalonate kinase; Region: mevalon_kin; TIGR00549 657310004685 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 657310004686 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 657310004687 diphosphomevalonate decarboxylase; Region: mevDPdecarb; TIGR01240 657310004688 diphosphomevalonate decarboxylase; Region: PLN02407 657310004689 phosphomevalonate kinase, ERG8-type, Gram-positive branch; Region: Pmev_kin_Gr_pos; TIGR01220 657310004690 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 657310004691 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 657310004692 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 657310004693 homotetramer interface [polypeptide binding]; other site 657310004694 FMN binding site [chemical binding]; other site 657310004695 homodimer contacts [polypeptide binding]; other site 657310004696 putative active site [active] 657310004697 putative substrate binding site [chemical binding]; other site 657310004698 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 657310004699 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 657310004700 putative catalytic cysteine [active] 657310004701 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 657310004702 putative active site [active] 657310004703 metal binding site [ion binding]; metal-binding site 657310004704 Preprotein translocase subunit; Region: YajC; pfam02699 657310004705 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 657310004706 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 657310004707 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 657310004708 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 657310004709 substrate binding pocket [chemical binding]; other site 657310004710 membrane-bound complex binding site; other site 657310004711 hinge residues; other site 657310004712 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 657310004713 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 657310004714 dimer interface [polypeptide binding]; other site 657310004715 conserved gate region; other site 657310004716 ABC-ATPase subunit interface; other site 657310004717 aspartate aminotransferase; Provisional; Region: PRK06348 657310004718 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 657310004719 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 657310004720 DXD motif; other site 657310004721 primosomal protein DnaI; Reviewed; Region: PRK08939 657310004722 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 657310004723 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 657310004724 Walker A motif; other site 657310004725 ATP binding site [chemical binding]; other site 657310004726 Walker B motif; other site 657310004727 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 657310004728 ATP cone domain; Region: ATP-cone; pfam03477 657310004729 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 657310004730 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 657310004731 CoA-binding site [chemical binding]; other site 657310004732 ATP-binding [chemical binding]; other site 657310004733 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 657310004734 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 657310004735 DNA binding site [nucleotide binding] 657310004736 catalytic residue [active] 657310004737 H2TH interface [polypeptide binding]; other site 657310004738 putative catalytic residues [active] 657310004739 turnover-facilitating residue; other site 657310004740 intercalation triad [nucleotide binding]; other site 657310004741 8OG recognition residue [nucleotide binding]; other site 657310004742 putative reading head residues; other site 657310004743 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 657310004744 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 657310004745 DNA polymerase I; Provisional; Region: PRK05755 657310004746 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 657310004747 active site 657310004748 metal binding site 1 [ion binding]; metal-binding site 657310004749 putative 5' ssDNA interaction site; other site 657310004750 metal binding site 3; metal-binding site 657310004751 metal binding site 2 [ion binding]; metal-binding site 657310004752 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 657310004753 putative DNA binding site [nucleotide binding]; other site 657310004754 putative metal binding site [ion binding]; other site 657310004755 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 657310004756 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 657310004757 active site 657310004758 DNA binding site [nucleotide binding] 657310004759 catalytic site [active] 657310004760 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 657310004761 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 657310004762 active site 657310004763 catalytic tetrad [active] 657310004764 Mga helix-turn-helix domain; Region: Mga; pfam05043 657310004765 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 657310004766 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 657310004767 Soluble P-type ATPase [General function prediction only]; Region: COG4087 657310004768 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 657310004769 non-specific DNA binding site [nucleotide binding]; other site 657310004770 salt bridge; other site 657310004771 sequence-specific DNA binding site [nucleotide binding]; other site 657310004772 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 657310004773 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 657310004774 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 657310004775 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 657310004776 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 657310004777 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 657310004778 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 657310004779 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 657310004780 salt bridge; other site 657310004781 non-specific DNA binding site [nucleotide binding]; other site 657310004782 sequence-specific DNA binding site [nucleotide binding]; other site 657310004783 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 657310004784 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 657310004785 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 657310004786 Zn binding site [ion binding]; other site 657310004787 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 657310004788 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 657310004789 Zn binding site [ion binding]; other site 657310004790 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 657310004791 dimer interface [polypeptide binding]; other site 657310004792 conserved gate region; other site 657310004793 putative PBP binding loops; other site 657310004794 ABC-ATPase subunit interface; other site 657310004795 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 657310004796 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 657310004797 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 657310004798 dimer interface [polypeptide binding]; other site 657310004799 conserved gate region; other site 657310004800 putative PBP binding loops; other site 657310004801 ABC-ATPase subunit interface; other site 657310004802 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 657310004803 Coenzyme A binding pocket [chemical binding]; other site 657310004804 Amino acid permease; Region: AA_permease_2; pfam13520 657310004805 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 657310004806 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 657310004807 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 657310004808 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 657310004809 active site residue [active] 657310004810 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 657310004811 Mga helix-turn-helix domain; Region: Mga; pfam05043 657310004812 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 657310004813 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 657310004814 Catalytic site [active] 657310004815 hypothetical protein; Provisional; Region: PRK11281 657310004816 PemK-like protein; Region: PemK; pfam02452 657310004817 alanine racemase; Reviewed; Region: alr; PRK00053 657310004818 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 657310004819 active site 657310004820 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 657310004821 dimer interface [polypeptide binding]; other site 657310004822 substrate binding site [chemical binding]; other site 657310004823 catalytic residues [active] 657310004824 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 657310004825 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 657310004826 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 657310004827 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 657310004828 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 657310004829 hypothetical protein; Validated; Region: PRK00124 657310004830 DNA gyrase B; Region: DNA_gyraseB; pfam00204 657310004831 ATP binding site [chemical binding]; other site 657310004832 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 657310004833 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 657310004834 substrate binding site [chemical binding]; other site 657310004835 ATP binding site [chemical binding]; other site 657310004836 probable amidohydrolase EF_0837/AHA_3915; Region: EF_0837; TIGR03583 657310004837 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 657310004838 active site 657310004839 Uncharacterized conserved protein [Function unknown]; Region: COG3589 657310004840 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 657310004841 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 657310004842 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 657310004843 conserved hypothetical protein EF_0833/AHA_3914; Region: EF_0833; TIGR03579 657310004844 Domain of unknown function (DUF4311); Region: DUF4311; cl11919 657310004845 conserved hypothetical protein EF_0831/AHA_3912; Region: EF_0831; TIGR03578 657310004846 Glycine-rich SFCGS; Region: Gly_rich_SFCGS; pfam14272 657310004847 PRD domain protein EF_0829/AHA_3910; Region: EF_0829; TIGR03582 657310004848 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 657310004849 HTH domain; Region: HTH_11; pfam08279 657310004850 HTH domain; Region: HTH_11; pfam08279 657310004851 PRD domain; Region: PRD; pfam00874 657310004852 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 657310004853 active site 657310004854 P-loop; other site 657310004855 phosphorylation site [posttranslational modification] 657310004856 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 657310004857 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 657310004858 PemK-like protein; Region: PemK; pfam02452 657310004859 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 657310004860 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 657310004861 Sugar specificity; other site 657310004862 Pyrimidine base specificity; other site 657310004863 ATP-binding site [chemical binding]; other site 657310004864 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 657310004865 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 657310004866 Coenzyme A binding pocket [chemical binding]; other site 657310004867 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 657310004868 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 657310004869 motif II; other site 657310004870 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 657310004871 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 657310004872 RNA binding surface [nucleotide binding]; other site 657310004873 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 657310004874 active site 657310004875 uracil binding [chemical binding]; other site 657310004876 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 657310004877 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 657310004878 5S rRNA interface [nucleotide binding]; other site 657310004879 CTC domain interface [polypeptide binding]; other site 657310004880 L16 interface [polypeptide binding]; other site 657310004881 Staphylococcal protein of unknown function (DUF960); Region: DUF960; pfam06124 657310004882 Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues; Region: GAG_Lyase; cd01083 657310004883 substrate binding site [chemical binding]; other site 657310004884 catalytic residues [active] 657310004885 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 657310004886 PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609 657310004887 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 657310004888 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 657310004889 DNA-binding site [nucleotide binding]; DNA binding site 657310004890 UTRA domain; Region: UTRA; pfam07702 657310004891 Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301 657310004892 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 657310004893 Uncharacterized protein conserved in bacteria (DUF2264); Region: DUF2264; pfam10022 657310004894 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 657310004895 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 657310004896 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 657310004897 peptide binding site [polypeptide binding]; other site 657310004898 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 657310004899 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 657310004900 dimer interface [polypeptide binding]; other site 657310004901 conserved gate region; other site 657310004902 putative PBP binding loops; other site 657310004903 ABC-ATPase subunit interface; other site 657310004904 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 657310004905 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 657310004906 Walker A/P-loop; other site 657310004907 ATP binding site [chemical binding]; other site 657310004908 Q-loop/lid; other site 657310004909 ABC transporter signature motif; other site 657310004910 Walker B; other site 657310004911 D-loop; other site 657310004912 H-loop/switch region; other site 657310004913 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 657310004914 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 657310004915 substrate binding pocket [chemical binding]; other site 657310004916 membrane-bound complex binding site; other site 657310004917 hinge residues; other site 657310004918 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 657310004919 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 657310004920 Ligand binding site; other site 657310004921 Putative Catalytic site; other site 657310004922 DXD motif; other site 657310004923 conserved hypothetical integral membrane protein; Region: TIGR03766 657310004924 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 657310004925 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 657310004926 HIGH motif; other site 657310004927 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 657310004928 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 657310004929 active site 657310004930 KMSKS motif; other site 657310004931 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 657310004932 tRNA binding surface [nucleotide binding]; other site 657310004933 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 657310004934 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 657310004935 Protein of unknown function (DUF1700); Region: DUF1700; pfam08006 657310004936 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 657310004937 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 657310004938 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 657310004939 active site 657310004940 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 657310004941 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 657310004942 Putative rRNA methylase; Region: rRNA_methylase; pfam06962 657310004943 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 657310004944 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 657310004945 Walker A/P-loop; other site 657310004946 ATP binding site [chemical binding]; other site 657310004947 Q-loop/lid; other site 657310004948 ABC transporter signature motif; other site 657310004949 Walker B; other site 657310004950 D-loop; other site 657310004951 H-loop/switch region; other site 657310004952 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 657310004953 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 657310004954 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 657310004955 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 657310004956 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 657310004957 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 657310004958 Walker A/P-loop; other site 657310004959 ATP binding site [chemical binding]; other site 657310004960 Q-loop/lid; other site 657310004961 ABC transporter signature motif; other site 657310004962 Walker B; other site 657310004963 D-loop; other site 657310004964 H-loop/switch region; other site 657310004965 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 657310004966 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 657310004967 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 657310004968 Walker A/P-loop; other site 657310004969 ATP binding site [chemical binding]; other site 657310004970 Q-loop/lid; other site 657310004971 ABC transporter signature motif; other site 657310004972 Walker B; other site 657310004973 D-loop; other site 657310004974 H-loop/switch region; other site 657310004975 tetracycline repressor protein TetR; Provisional; Region: PRK13756 657310004976 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 657310004977 Predicted esterase [General function prediction only]; Region: COG0627 657310004978 S-formylglutathione hydrolase; Region: PLN02442 657310004979 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 657310004980 Major Facilitator Superfamily; Region: MFS_1; pfam07690 657310004981 putative substrate translocation pore; other site 657310004982 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 657310004983 S-adenosylmethionine synthetase; Validated; Region: PRK05250 657310004984 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 657310004985 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 657310004986 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 657310004987 RNA polymerase sigma-54 factor; Region: rpoN_sigma; TIGR02395 657310004988 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 657310004989 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 657310004990 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 657310004991 DNA-binding site [nucleotide binding]; DNA binding site 657310004992 RNA-binding motif; other site 657310004993 WxL domain surface cell wall-binding; Region: WxL; pfam13731 657310004994 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 657310004995 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 657310004996 Predicted SPOUT methyltransferase; Region: SPOUT_MTase; cl00679 657310004997 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 657310004998 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 657310004999 DNA binding site [nucleotide binding] 657310005000 Mga helix-turn-helix domain; Region: Mga; pfam05043 657310005001 Mga helix-turn-helix domain; Region: Mga; pfam05043 657310005002 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 657310005003 nudix motif; other site 657310005004 Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; pfam10110 657310005005 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 657310005006 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 657310005007 active site 657310005008 catalytic site [active] 657310005009 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 657310005010 Protein of unknown function (DUF1622); Region: DUF1622; pfam07784 657310005011 Clp protease; Region: CLP_protease; pfam00574 657310005012 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 657310005013 oligomer interface [polypeptide binding]; other site 657310005014 active site residues [active] 657310005015 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 657310005016 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 657310005017 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 657310005018 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 657310005019 phosphate binding site [ion binding]; other site 657310005020 putative substrate binding pocket [chemical binding]; other site 657310005021 dimer interface [polypeptide binding]; other site 657310005022 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 657310005023 YusW-like protein; Region: YusW; pfam14039 657310005024 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 657310005025 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 657310005026 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 657310005027 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 657310005028 excinuclease ABC subunit B; Provisional; Region: PRK05298 657310005029 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 657310005030 ATP binding site [chemical binding]; other site 657310005031 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 657310005032 nucleotide binding region [chemical binding]; other site 657310005033 ATP-binding site [chemical binding]; other site 657310005034 Ultra-violet resistance protein B; Region: UvrB; pfam12344 657310005035 UvrB/uvrC motif; Region: UVR; pfam02151 657310005036 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 657310005037 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 657310005038 substrate binding pocket [chemical binding]; other site 657310005039 membrane-bound complex binding site; other site 657310005040 hinge residues; other site 657310005041 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 657310005042 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 657310005043 substrate binding pocket [chemical binding]; other site 657310005044 membrane-bound complex binding site; other site 657310005045 hinge residues; other site 657310005046 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 657310005047 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 657310005048 dimer interface [polypeptide binding]; other site 657310005049 conserved gate region; other site 657310005050 putative PBP binding loops; other site 657310005051 ABC-ATPase subunit interface; other site 657310005052 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 657310005053 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 657310005054 Walker A/P-loop; other site 657310005055 ATP binding site [chemical binding]; other site 657310005056 Q-loop/lid; other site 657310005057 ABC transporter signature motif; other site 657310005058 Walker B; other site 657310005059 D-loop; other site 657310005060 H-loop/switch region; other site 657310005061 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 657310005062 MgtC family; Region: MgtC; pfam02308 657310005063 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 657310005064 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 657310005065 Soluble P-type ATPase [General function prediction only]; Region: COG4087 657310005066 WxL domain surface cell wall-binding; Region: WxL; pfam13731 657310005067 legume lectins; Region: lectin_L-type; cd01951 657310005068 homotetramer interaction site [polypeptide binding]; other site 657310005069 homodimer interaction site [polypeptide binding]; other site 657310005070 carbohydrate binding site [chemical binding]; other site 657310005071 metal binding site [ion binding]; metal-binding site 657310005072 WxL domain surface cell wall-binding; Region: WxL; pfam13731 657310005073 WxL domain surface cell wall-binding; Region: WxL; pfam13731 657310005074 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 657310005075 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 657310005076 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 657310005077 active site residue [active] 657310005078 Protein of unknown function (DUF3650); Region: DUF3650; pfam12368 657310005079 Predicted membrane protein [Function unknown]; Region: COG4420 657310005080 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 657310005081 Beta-lactamase; Region: Beta-lactamase; pfam00144 657310005082 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 657310005083 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 657310005084 Protein of unknown function (DUF1149); Region: DUF1149; pfam06619 657310005085 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 657310005086 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 657310005087 Substrate-binding site [chemical binding]; other site 657310005088 Substrate specificity [chemical binding]; other site 657310005089 amidase; Provisional; Region: PRK06707 657310005090 Amidase; Region: Amidase; cl11426 657310005091 carbamate kinase; Reviewed; Region: PRK12686 657310005092 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 657310005093 putative substrate binding site [chemical binding]; other site 657310005094 nucleotide binding site [chemical binding]; other site 657310005095 nucleotide binding site [chemical binding]; other site 657310005096 homodimer interface [polypeptide binding]; other site 657310005097 agmatine deiminase; Provisional; Region: PRK13551 657310005098 agmatine deiminase; Region: agmatine_aguA; TIGR03380 657310005099 putrescine carbamoyltransferase; Provisional; Region: PRK02255 657310005100 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 657310005101 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 657310005102 Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cl02626 657310005103 active site 657310005104 DNA binding site [nucleotide binding] 657310005105 catalytic site [active] 657310005106 Protein of unknown function (DUF2815); Region: DUF2815; pfam10991 657310005107 Protein of unknown function (DUF2800); Region: DUF2800; pfam10926 657310005108 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 657310005109 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 657310005110 Walker A/P-loop; other site 657310005111 ATP binding site [chemical binding]; other site 657310005112 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 657310005113 non-specific DNA binding site [nucleotide binding]; other site 657310005114 salt bridge; other site 657310005115 sequence-specific DNA binding site [nucleotide binding]; other site 657310005116 DEAD-like helicases superfamily; Region: DEXDc; smart00487 657310005117 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 657310005118 ATP binding site [chemical binding]; other site 657310005119 putative Mg++ binding site [ion binding]; other site 657310005120 Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002 657310005121 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 657310005122 non-specific DNA binding site [nucleotide binding]; other site 657310005123 salt bridge; other site 657310005124 sequence-specific DNA binding site [nucleotide binding]; other site 657310005125 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria and archaea; Region: GIY-YIG_unchar_2; cd10447 657310005126 GIY-YIG motif/motif A; other site 657310005127 putative active site [active] 657310005128 putative metal binding site [ion binding]; other site 657310005129 TRAM domain; Region: TRAM; pfam01938 657310005130 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 657310005131 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 657310005132 S-adenosylmethionine binding site [chemical binding]; other site 657310005133 putative lipid kinase; Reviewed; Region: PRK13055 657310005134 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 657310005135 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 657310005136 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 657310005137 GatB domain; Region: GatB_Yqey; smart00845 657310005138 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 657310005139 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 657310005140 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 657310005141 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 657310005142 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 657310005143 nucleotide binding pocket [chemical binding]; other site 657310005144 K-X-D-G motif; other site 657310005145 catalytic site [active] 657310005146 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 657310005147 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 657310005148 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 657310005149 Dimer interface [polypeptide binding]; other site 657310005150 BRCT sequence motif; other site 657310005151 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 657310005152 Part of AAA domain; Region: AAA_19; pfam13245 657310005153 Family description; Region: UvrD_C_2; pfam13538 657310005154 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 657310005155 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 657310005156 Cl- selectivity filter; other site 657310005157 Cl- binding residues [ion binding]; other site 657310005158 pore gating glutamate residue; other site 657310005159 dimer interface [polypeptide binding]; other site 657310005160 H+/Cl- coupling transport residue; other site 657310005161 TrkA-C domain; Region: TrkA_C; pfam02080 657310005162 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 657310005163 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 657310005164 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 657310005165 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 657310005166 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 657310005167 putative substrate binding site [chemical binding]; other site 657310005168 putative ATP binding site [chemical binding]; other site 657310005169 trigger factor; Provisional; Region: tig; PRK01490 657310005170 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 657310005171 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 657310005172 WxL domain surface cell wall-binding; Region: WxL; pfam13731 657310005173 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 657310005174 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 657310005175 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 657310005176 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 657310005177 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 657310005178 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 657310005179 dimerization domain swap beta strand [polypeptide binding]; other site 657310005180 regulatory protein interface [polypeptide binding]; other site 657310005181 active site 657310005182 regulatory phosphorylation site [posttranslational modification]; other site 657310005183 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 657310005184 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 657310005185 Walker A motif; other site 657310005186 ATP binding site [chemical binding]; other site 657310005187 Walker B motif; other site 657310005188 arginine finger; other site 657310005189 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 657310005190 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 657310005191 Walker A motif; other site 657310005192 ATP binding site [chemical binding]; other site 657310005193 Walker B motif; other site 657310005194 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 657310005195 Predicted membrane protein [Function unknown]; Region: COG2323 657310005196 Protein of unknown function (DUF3290); Region: DUF3290; pfam11694 657310005197 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 657310005198 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 657310005199 G1 box; other site 657310005200 putative GEF interaction site [polypeptide binding]; other site 657310005201 GTP/Mg2+ binding site [chemical binding]; other site 657310005202 Switch I region; other site 657310005203 G2 box; other site 657310005204 G3 box; other site 657310005205 Switch II region; other site 657310005206 G4 box; other site 657310005207 G5 box; other site 657310005208 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 657310005209 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 657310005210 Domain of unknown function DUF21; Region: DUF21; pfam01595 657310005211 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 657310005212 Transporter associated domain; Region: CorC_HlyC; pfam03471 657310005213 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444 657310005214 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 657310005215 Coenzyme A binding pocket [chemical binding]; other site 657310005216 hypothetical protein; Provisional; Region: PRK13662 657310005217 tagatose 1,6-diphosphate aldolase; Reviewed; Region: PRK12399 657310005218 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 657310005219 active site 657310005220 phosphorylation site [posttranslational modification] 657310005221 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 657310005222 active site 657310005223 P-loop; other site 657310005224 phosphorylation site [posttranslational modification] 657310005225 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 657310005226 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 657310005227 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 657310005228 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 657310005229 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 657310005230 putative active site [active] 657310005231 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 657310005232 S-adenosylmethionine binding site [chemical binding]; other site 657310005233 Thiamine kinase and related kinases [Coenzyme transport and metabolism]; Region: ycfN; COG0510 657310005234 Phosphotransferase enzyme family; Region: APH; pfam01636 657310005235 active site 657310005236 substrate binding site [chemical binding]; other site 657310005237 ATP binding site [chemical binding]; other site 657310005238 Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975 657310005239 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 657310005240 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 657310005241 Walker A/P-loop; other site 657310005242 ATP binding site [chemical binding]; other site 657310005243 Q-loop/lid; other site 657310005244 ABC transporter signature motif; other site 657310005245 Walker B; other site 657310005246 D-loop; other site 657310005247 H-loop/switch region; other site 657310005248 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 657310005249 HIT family signature motif; other site 657310005250 catalytic residue [active] 657310005251 foldase protein PrsA; Reviewed; Region: prsA; PRK01326 657310005252 Uncharacterized conserved protein [Function unknown]; Region: COG4717 657310005253 Uncharacterized conserved protein [Function unknown]; Region: COG4717 657310005254 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 657310005255 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 657310005256 active site 657310005257 metal binding site [ion binding]; metal-binding site 657310005258 DNA binding site [nucleotide binding] 657310005259 Transglycosylase; Region: Transgly; pfam00912 657310005260 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 657310005261 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 657310005262 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 657310005263 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 657310005264 active site 657310005265 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 657310005266 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 657310005267 Arginine repressor [Transcription]; Region: ArgR; COG1438 657310005268 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 657310005269 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 657310005270 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 657310005271 ABC-ATPase subunit interface; other site 657310005272 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 657310005273 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 657310005274 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 657310005275 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 657310005276 Walker A/P-loop; other site 657310005277 ATP binding site [chemical binding]; other site 657310005278 Q-loop/lid; other site 657310005279 ABC transporter signature motif; other site 657310005280 Walker B; other site 657310005281 D-loop; other site 657310005282 H-loop/switch region; other site 657310005283 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 657310005284 Acyltransferase family; Region: Acyl_transf_3; pfam01757 657310005285 DNA primase large subunit; Validated; Region: PRK03968 657310005286 dipeptidase PepV; Region: dipeptidase; TIGR01886 657310005287 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 657310005288 active site 657310005289 metal binding site [ion binding]; metal-binding site 657310005290 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 657310005291 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 657310005292 RNA binding surface [nucleotide binding]; other site 657310005293 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 657310005294 active site 657310005295 uracil binding [chemical binding]; other site 657310005296 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 657310005297 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 657310005298 putative hydrolase; Provisional; Region: PRK11460 657310005299 Predicted esterase [General function prediction only]; Region: COG0400 657310005300 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 657310005301 Zn binding site [ion binding]; other site 657310005302 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 657310005303 Zn binding site [ion binding]; other site 657310005304 C_GCAxxG_C_C family probable redox protein; Region: C_GCAxxG_C_C; TIGR01909 657310005305 hypothetical protein; Validated; Region: PRK00110 657310005306 Predicted integral membrane protein [Function unknown]; Region: COG5652 657310005307 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 657310005308 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_2; cd09607 657310005309 active site 657310005310 Zn binding site [ion binding]; other site 657310005311 multidrug efflux pump VmrA; Reviewed; Region: vmrA; PRK09575 657310005312 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 657310005313 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 657310005314 active site 657310005315 Fe-S cluster binding site [ion binding]; other site 657310005316 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 657310005317 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 657310005318 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 657310005319 active site 657310005320 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 657310005321 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 657310005322 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 657310005323 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 657310005324 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 657310005325 putative metal binding site [ion binding]; other site 657310005326 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 657310005327 active site 657310005328 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 657310005329 dimer interface [polypeptide binding]; other site 657310005330 FMN binding site [chemical binding]; other site 657310005331 Transcriptional regulators [Transcription]; Region: PurR; COG1609 657310005332 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 657310005333 DNA binding site [nucleotide binding] 657310005334 domain linker motif; other site 657310005335 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 657310005336 putative dimerization interface [polypeptide binding]; other site 657310005337 putative ligand binding site [chemical binding]; other site 657310005338 Peptidase family M48; Region: Peptidase_M48; cl12018 657310005339 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 657310005340 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 657310005341 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 657310005342 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 657310005343 dimer interface [polypeptide binding]; other site 657310005344 FMN binding site [chemical binding]; other site 657310005345 Predicted transcriptional regulators [Transcription]; Region: COG1733 657310005346 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 657310005347 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 657310005348 C4-dicarboxylate transporters of the Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_C4-dicarb_trans; cd09325 657310005349 gating phenylalanine in ion channel; other site 657310005350 Transcriptional regulator [Transcription]; Region: LysR; COG0583 657310005351 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 657310005352 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 657310005353 dimerization interface [polypeptide binding]; other site 657310005354 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 657310005355 tetramer (dimer of dimers) interface [polypeptide binding]; other site 657310005356 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 657310005357 NAD binding site [chemical binding]; other site 657310005358 dimer interface [polypeptide binding]; other site 657310005359 substrate binding site [chemical binding]; other site 657310005360 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 657310005361 tetramer interfaces [polypeptide binding]; other site 657310005362 binuclear metal-binding site [ion binding]; other site 657310005363 Protein of unknown function (DUF1307); Region: DUF1307; pfam06998 657310005364 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 657310005365 tyrosine decarboxylase, Enterococcus type; Region: tyr_de_CO2_Ent; TIGR03811 657310005366 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 657310005367 catalytic residue [active] 657310005368 tyrosyl-tRNA synthetase; Provisional; Region: PRK13354 657310005369 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 657310005370 active site 657310005371 HIGH motif; other site 657310005372 dimer interface [polypeptide binding]; other site 657310005373 KMSKS motif; other site 657310005374 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 657310005375 RNA binding surface [nucleotide binding]; other site 657310005376 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 657310005377 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 657310005378 active site 657310005379 metal binding site [ion binding]; metal-binding site 657310005380 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 657310005381 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 657310005382 active site 657310005383 catalytic tetrad [active] 657310005384 Transposase, Mutator family; Region: Transposase_mut; pfam00872 657310005385 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 657310005386 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 657310005387 Walker A motif; other site 657310005388 ATP binding site [chemical binding]; other site 657310005389 Walker B motif; other site 657310005390 arginine finger; other site 657310005391 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 657310005392 Walker A motif; other site 657310005393 ATP binding site [chemical binding]; other site 657310005394 Walker B motif; other site 657310005395 arginine finger; other site 657310005396 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 657310005397 Transposase, Mutator family; Region: Transposase_mut; pfam00872 657310005398 MULE transposase domain; Region: MULE; pfam10551 657310005399 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 657310005400 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 657310005401 Transposase; Region: DDE_Tnp_ISL3; pfam01610 657310005402 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 657310005403 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 657310005404 Isochorismatase family; Region: Isochorismatase; pfam00857 657310005405 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 657310005406 catalytic triad [active] 657310005407 conserved cis-peptide bond; other site 657310005408 pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK07251 657310005409 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 657310005410 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 657310005411 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 657310005412 Helix-turn-helix domain; Region: HTH_28; pfam13518 657310005413 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 657310005414 Homeodomain-like domain; Region: HTH_23; cl17451 657310005415 Integrase core domain; Region: rve; pfam00665 657310005416 Integrase core domain; Region: rve_2; pfam13333 657310005417 D-lactate dehydrogenase; Provisional; Region: PRK11183 657310005418 D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330 657310005419 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 657310005420 DNA-binding interface [nucleotide binding]; DNA binding site 657310005421 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 657310005422 putative substrate translocation pore; other site 657310005423 multicopper oxidase; Provisional; Region: PRK10965 657310005424 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 657310005425 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 657310005426 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 657310005427 Integrase core domain; Region: rve; pfam00665 657310005428 Helix-turn-helix domain; Region: HTH_17; pfam12728 657310005429 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 657310005430 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 657310005431 G1 box; other site 657310005432 GTP/Mg2+ binding site [chemical binding]; other site 657310005433 Switch I region; other site 657310005434 G2 box; other site 657310005435 G3 box; other site 657310005436 Switch II region; other site 657310005437 G4 box; other site 657310005438 G5 box; other site 657310005439 Nucleoside recognition; Region: Gate; pfam07670 657310005440 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 657310005441 Nucleoside recognition; Region: Gate; pfam07670 657310005442 Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918 657310005443 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 657310005444 catalytic residues [active] 657310005445 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 657310005446 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 657310005447 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 657310005448 dimer interface [polypeptide binding]; other site 657310005449 putative radical transfer pathway; other site 657310005450 diiron center [ion binding]; other site 657310005451 tyrosyl radical; other site 657310005452 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 657310005453 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 657310005454 MgtC family; Region: MgtC; pfam02308 657310005455 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 657310005456 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 657310005457 active site 657310005458 trimer interface [polypeptide binding]; other site 657310005459 allosteric site; other site 657310005460 active site lid [active] 657310005461 hexamer (dimer of trimers) interface [polypeptide binding]; other site 657310005462 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 657310005463 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 657310005464 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 657310005465 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 657310005466 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 657310005467 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 657310005468 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 657310005469 Protein of unknown function (DUF1189); Region: DUF1189; pfam06691 657310005470 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 657310005471 active pocket/dimerization site; other site 657310005472 active site 657310005473 phosphorylation site [posttranslational modification] 657310005474 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 657310005475 Beta-lactamase; Region: Beta-lactamase; pfam00144 657310005476 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: PRK12570 657310005477 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 657310005478 putative active site [active] 657310005479 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11557 657310005480 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 657310005481 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 657310005482 putative active site [active] 657310005483 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 657310005484 active site 657310005485 phosphorylation site [posttranslational modification] 657310005486 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 657310005487 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 657310005488 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 657310005489 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 657310005490 active site 657310005491 trimer interface [polypeptide binding]; other site 657310005492 allosteric site; other site 657310005493 hexamer (dimer of trimers) interface [polypeptide binding]; other site 657310005494 N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317 657310005495 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 657310005496 active site 657310005497 octamer interface [polypeptide binding]; other site 657310005498 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 657310005499 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 657310005500 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 657310005501 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 657310005502 dimer interface [polypeptide binding]; other site 657310005503 tetramer interface [polypeptide binding]; other site 657310005504 PYR/PP interface [polypeptide binding]; other site 657310005505 TPP binding site [chemical binding]; other site 657310005506 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 657310005507 TPP-binding site; other site 657310005508 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 657310005509 isochorismate synthases; Region: isochor_syn; TIGR00543 657310005510 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK03640 657310005511 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 657310005512 acyl-activating enzyme (AAE) consensus motif; other site 657310005513 putative AMP binding site [chemical binding]; other site 657310005514 putative active site [active] 657310005515 putative CoA binding site [chemical binding]; other site 657310005516 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 657310005517 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 657310005518 substrate binding site [chemical binding]; other site 657310005519 oxyanion hole (OAH) forming residues; other site 657310005520 trimer interface [polypeptide binding]; other site 657310005521 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 657310005522 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 657310005523 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 657310005524 Metal-binding active site; metal-binding site 657310005525 Domain of unknown function (DUF718); Region: DUF718; cl01281 657310005526 rhamnulose-1-phosphate aldolase; Region: rhamnu_1P_ald; TIGR02624 657310005527 intersubunit interface [polypeptide binding]; other site 657310005528 active site 657310005529 Zn2+ binding site [ion binding]; other site 657310005530 L-rhamnose isomerase; Provisional; Region: PRK01076 657310005531 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 657310005532 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 657310005533 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 657310005534 DctM-like transporters; Region: DctM; pfam06808 657310005535 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 657310005536 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 657310005537 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 657310005538 gluconate 5-dehydrogenase; Provisional; Region: PRK07097 657310005539 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 657310005540 NADP binding site [chemical binding]; other site 657310005541 homodimer interface [polypeptide binding]; other site 657310005542 active site 657310005543 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 657310005544 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 657310005545 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 657310005546 substrate binding site [chemical binding]; other site 657310005547 ATP binding site [chemical binding]; other site 657310005548 Transcriptional regulator [Transcription]; Region: IclR; COG1414 657310005549 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 657310005550 Bacterial transcriptional regulator; Region: IclR; pfam01614 657310005551 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 657310005552 DNA binding residues [nucleotide binding] 657310005553 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 657310005554 putative dimer interface [polypeptide binding]; other site 657310005555 TrbC/VIRB2 family; Region: TrbC; pfam04956 657310005556 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 657310005557 FtsX-like permease family; Region: FtsX; pfam02687 657310005558 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 657310005559 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 657310005560 Walker A/P-loop; other site 657310005561 ATP binding site [chemical binding]; other site 657310005562 Q-loop/lid; other site 657310005563 ABC transporter signature motif; other site 657310005564 Walker B; other site 657310005565 D-loop; other site 657310005566 H-loop/switch region; other site 657310005567 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 657310005568 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 657310005569 NADH(P)-binding; Region: NAD_binding_10; pfam13460 657310005570 NAD(P) binding site [chemical binding]; other site 657310005571 active site 657310005572 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 657310005573 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 657310005574 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 657310005575 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 657310005576 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 657310005577 active site 657310005578 phosphorylation site [posttranslational modification] 657310005579 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 657310005580 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 657310005581 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 657310005582 active site 657310005583 P-loop; other site 657310005584 phosphorylation site [posttranslational modification] 657310005585 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 657310005586 active site 657310005587 P-loop; other site 657310005588 phosphorylation site [posttranslational modification] 657310005589 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 657310005590 active site 657310005591 phosphorylation site [posttranslational modification] 657310005592 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 657310005593 PRD domain; Region: PRD; pfam00874 657310005594 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 657310005595 P-loop; other site 657310005596 active site 657310005597 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 657310005598 active site 657310005599 phosphorylation site [posttranslational modification] 657310005600 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 657310005601 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 657310005602 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 657310005603 active site 657310005604 P-loop; other site 657310005605 phosphorylation site [posttranslational modification] 657310005606 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 657310005607 active site 657310005608 P-loop; other site 657310005609 phosphorylation site [posttranslational modification] 657310005610 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 657310005611 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 657310005612 active site 657310005613 motif I; other site 657310005614 motif II; other site 657310005615 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 657310005616 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 657310005617 dimer interface [polypeptide binding]; other site 657310005618 FMN binding site [chemical binding]; other site 657310005619 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 657310005620 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 657310005621 putative DNA binding site [nucleotide binding]; other site 657310005622 putative Zn2+ binding site [ion binding]; other site 657310005623 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 657310005624 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 657310005625 putative substrate binding pocket [chemical binding]; other site 657310005626 AC domain interface; other site 657310005627 catalytic triad [active] 657310005628 AB domain interface; other site 657310005629 interchain disulfide; other site 657310005630 Predicted membrane protein [Function unknown]; Region: COG3817 657310005631 Protein of unknown function (DUF979); Region: DUF979; pfam06166 657310005632 Protein of unknown function (DUF969); Region: DUF969; pfam06149 657310005633 Short repeat of unknown function (DUF308); Region: DUF308; cl15828 657310005634 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 657310005635 Domain of unknown function DUF20; Region: UPF0118; pfam01594 657310005636 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 657310005637 substrate binding site [chemical binding]; other site 657310005638 THF binding site; other site 657310005639 zinc-binding site [ion binding]; other site 657310005640 WxL domain surface cell wall-binding; Region: WxL; pfam13731 657310005641 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 657310005642 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 657310005643 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 657310005644 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 657310005645 D-galactonate transporter; Region: 2A0114; TIGR00893 657310005646 putative substrate translocation pore; other site 657310005647 membrane protein FdrA; Validated; Region: PRK06091 657310005648 CoA binding domain; Region: CoA_binding; pfam02629 657310005649 CoA-ligase; Region: Ligase_CoA; pfam00549 657310005650 Protein of unknown function (DUF1116); Region: DUF1116; pfam06545 657310005651 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 657310005652 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 657310005653 putative deaminase; Validated; Region: PRK06846 657310005654 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 657310005655 active site 657310005656 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 657310005657 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 657310005658 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 657310005659 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 657310005660 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 657310005661 active site 657310005662 phosphorylation site [posttranslational modification] 657310005663 intermolecular recognition site; other site 657310005664 dimerization interface [polypeptide binding]; other site 657310005665 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 657310005666 DNA binding site [nucleotide binding] 657310005667 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 657310005668 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 657310005669 motif II; other site 657310005670 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4696 657310005671 metal binding site [ion binding]; metal-binding site 657310005672 Protein of unknown function DUF72; Region: DUF72; pfam01904 657310005673 GH18 domain of Chitinase D (ChiD). ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins. The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18; Region: GH18_chitinase_D-like; cd02871 657310005674 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 657310005675 putative active site [active] 657310005676 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 657310005677 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 657310005678 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 657310005679 Zn binding site [ion binding]; other site 657310005680 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 657310005681 Zn binding site [ion binding]; other site 657310005682 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 657310005683 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 657310005684 trimer interface [polypeptide binding]; other site 657310005685 active site 657310005686 G bulge; other site 657310005687 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 657310005688 DNA-binding site [nucleotide binding]; DNA binding site 657310005689 Predicted membrane protein [General function prediction only]; Region: COG4194 657310005690 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 657310005691 metal-binding site [ion binding] 657310005692 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 657310005693 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 657310005694 metal-binding site [ion binding] 657310005695 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 657310005696 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 657310005697 metal-binding site [ion binding] 657310005698 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 657310005699 Soluble P-type ATPase [General function prediction only]; Region: COG4087 657310005700 copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698 657310005701 Penicillinase repressor; Region: Pencillinase_R; pfam03965 657310005702 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 657310005703 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 657310005704 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 657310005705 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 657310005706 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 657310005707 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 657310005708 6-phospho-beta-glucosidase; Reviewed; Region: celA; PRK09589 657310005709 beta-galactosidase; Region: BGL; TIGR03356 657310005710 cystathionine gamma-synthase/cystathionine beta-lyase; Validated; Region: PRK06176 657310005711 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 657310005712 homodimer interface [polypeptide binding]; other site 657310005713 substrate-cofactor binding pocket; other site 657310005714 pyridoxal 5'-phosphate binding site [chemical binding]; other site 657310005715 catalytic residue [active] 657310005716 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 657310005717 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 657310005718 dimer interface [polypeptide binding]; other site 657310005719 pyridoxal 5'-phosphate binding site [chemical binding]; other site 657310005720 catalytic residue [active] 657310005721 elongation factor P; Validated; Region: PRK00529 657310005722 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 657310005723 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 657310005724 RNA binding site [nucleotide binding]; other site 657310005725 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 657310005726 RNA binding site [nucleotide binding]; other site 657310005727 Fibronectin-binding protein (FBP); Region: FBP; pfam07299 657310005728 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 657310005729 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 657310005730 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 657310005731 dimer interface [polypeptide binding]; other site 657310005732 active site 657310005733 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK06079 657310005734 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 657310005735 NAD binding site [chemical binding]; other site 657310005736 homotetramer interface [polypeptide binding]; other site 657310005737 homodimer interface [polypeptide binding]; other site 657310005738 substrate binding site [chemical binding]; other site 657310005739 active site 657310005740 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 657310005741 Cation efflux family; Region: Cation_efflux; pfam01545 657310005742 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 657310005743 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 657310005744 Zn2+ binding site [ion binding]; other site 657310005745 Mg2+ binding site [ion binding]; other site 657310005746 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 657310005747 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 657310005748 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 657310005749 DNA binding site [nucleotide binding] 657310005750 active site 657310005751 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 657310005752 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 657310005753 catalytic core [active] 657310005754 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 657310005755 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 657310005756 beta-galactosidase; Region: BGL; TIGR03356 657310005757 6-phospho-beta-glucosidase; Reviewed; Region: arb; PRK09593 657310005758 beta-galactosidase; Region: BGL; TIGR03356 657310005759 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 657310005760 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 657310005761 active site turn [active] 657310005762 phosphorylation site [posttranslational modification] 657310005763 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 657310005764 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 657310005765 HPr interaction site; other site 657310005766 glycerol kinase (GK) interaction site [polypeptide binding]; other site 657310005767 active site 657310005768 phosphorylation site [posttranslational modification] 657310005769 general stress protein 13; Validated; Region: PRK08059 657310005770 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 657310005771 RNA binding site [nucleotide binding]; other site 657310005772 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 657310005773 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 657310005774 pyridoxal 5'-phosphate binding site [chemical binding]; other site 657310005775 homodimer interface [polypeptide binding]; other site 657310005776 catalytic residue [active] 657310005777 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 657310005778 active site 657310005779 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 657310005780 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 657310005781 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 657310005782 Phosphoglycerate Dehydrogenase, 2-hydroxyacid dehydrogenase family; Region: PGDH_1; cd12155 657310005783 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 657310005784 putative ligand binding site [chemical binding]; other site 657310005785 NAD binding site [chemical binding]; other site 657310005786 catalytic site [active] 657310005787 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 657310005788 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 657310005789 active site 657310005790 metal binding site [ion binding]; metal-binding site 657310005791 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 657310005792 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 657310005793 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 657310005794 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 657310005795 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 657310005796 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 657310005797 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 657310005798 dimer interface [polypeptide binding]; other site 657310005799 conserved gate region; other site 657310005800 putative PBP binding loops; other site 657310005801 ABC-ATPase subunit interface; other site 657310005802 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 657310005803 dimer interface [polypeptide binding]; other site 657310005804 conserved gate region; other site 657310005805 putative PBP binding loops; other site 657310005806 ABC-ATPase subunit interface; other site 657310005807 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 657310005808 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 657310005809 Walker A/P-loop; other site 657310005810 ATP binding site [chemical binding]; other site 657310005811 Q-loop/lid; other site 657310005812 ABC transporter signature motif; other site 657310005813 Walker B; other site 657310005814 D-loop; other site 657310005815 H-loop/switch region; other site 657310005816 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 657310005817 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 657310005818 Ligand binding site; other site 657310005819 Putative Catalytic site; other site 657310005820 DXD motif; other site 657310005821 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 657310005822 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 657310005823 TrkA-N domain; Region: TrkA_N; pfam02254 657310005824 TrkA-C domain; Region: TrkA_C; pfam02080 657310005825 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 657310005826 Histidine kinase; Region: HisKA_3; pfam07730 657310005827 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 657310005828 ATP binding site [chemical binding]; other site 657310005829 Mg2+ binding site [ion binding]; other site 657310005830 G-X-G motif; other site 657310005831 Predicted membrane protein [Function unknown]; Region: COG4758 657310005832 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 657310005833 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 657310005834 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 657310005835 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 657310005836 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 657310005837 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 657310005838 motif II; other site 657310005839 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 657310005840 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 657310005841 active site 657310005842 homodimer interface [polypeptide binding]; other site 657310005843 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832 657310005844 Protein of unknown function (DUF1447); Region: DUF1447; pfam07288 657310005845 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 657310005846 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 657310005847 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 657310005848 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 657310005849 DNA-binding site [nucleotide binding]; DNA binding site 657310005850 RNA-binding motif; other site 657310005851 hypothetical protein; Reviewed; Region: PRK00024 657310005852 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 657310005853 MPN+ (JAMM) motif; other site 657310005854 Zinc-binding site [ion binding]; other site 657310005855 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 657310005856 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 657310005857 motif II; other site 657310005858 folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499 657310005859 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 657310005860 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 657310005861 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 657310005862 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 657310005863 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 657310005864 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 657310005865 active site 657310005866 HIGH motif; other site 657310005867 nucleotide binding site [chemical binding]; other site 657310005868 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 657310005869 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 657310005870 active site 657310005871 KMSKS motif; other site 657310005872 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 657310005873 tRNA binding surface [nucleotide binding]; other site 657310005874 anticodon binding site; other site 657310005875 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 657310005876 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 657310005877 dimer interface [polypeptide binding]; other site 657310005878 catalytic triad [active] 657310005879 peroxidatic and resolving cysteines [active] 657310005880 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 657310005881 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 657310005882 CoA binding domain; Region: CoA_binding; pfam02629 657310005883 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 657310005884 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 657310005885 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 657310005886 NAD(P) binding site [chemical binding]; other site 657310005887 active site 657310005888 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 657310005889 active site 657310005890 substrate binding site [chemical binding]; other site 657310005891 trimer interface [polypeptide binding]; other site 657310005892 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 657310005893 CoA binding site [chemical binding]; other site 657310005894 Transcriptional regulator [Transcription]; Region: LysR; COG0583 657310005895 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 657310005896 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 657310005897 dimerization interface [polypeptide binding]; other site 657310005898 Sugar transport protein; Region: Sugar_transport; pfam06800 657310005899 D-ribose pyranase; Provisional; Region: PRK11797 657310005900 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 657310005901 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 657310005902 substrate binding site [chemical binding]; other site 657310005903 dimer interface [polypeptide binding]; other site 657310005904 ATP binding site [chemical binding]; other site 657310005905 Transcriptional regulators [Transcription]; Region: PurR; COG1609 657310005906 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 657310005907 DNA binding site [nucleotide binding] 657310005908 domain linker motif; other site 657310005909 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 657310005910 dimerization interface [polypeptide binding]; other site 657310005911 ligand binding site [chemical binding]; other site 657310005912 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 657310005913 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 657310005914 active site 657310005915 P-loop; other site 657310005916 phosphorylation site [posttranslational modification] 657310005917 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 657310005918 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 657310005919 WxL domain surface cell wall-binding; Region: WxL; pfam13731 657310005920 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 657310005921 Amidinotransferase; Region: Amidinotransf; cl12043 657310005922 Alkaline phosphatase homologues; Region: alkPPc; smart00098 657310005923 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 657310005924 active site 657310005925 dimer interface [polypeptide binding]; other site 657310005926 MutS domain III; Region: MutS_III; pfam05192 657310005927 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 657310005928 Walker A/P-loop; other site 657310005929 ATP binding site [chemical binding]; other site 657310005930 Q-loop/lid; other site 657310005931 ABC transporter signature motif; other site 657310005932 Walker B; other site 657310005933 D-loop; other site 657310005934 H-loop/switch region; other site 657310005935 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 657310005936 PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609 657310005937 PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830 657310005938 active site 657310005939 phosphorylation site [posttranslational modification] 657310005940 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 657310005941 active pocket/dimerization site; other site 657310005942 active site 657310005943 phosphorylation site [posttranslational modification] 657310005944 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 657310005945 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 657310005946 Walker A motif; other site 657310005947 ATP binding site [chemical binding]; other site 657310005948 Walker B motif; other site 657310005949 arginine finger; other site 657310005950 PRD domain; Region: PRD; pfam00874 657310005951 Transcriptional antiterminator [Transcription]; Region: COG3933 657310005952 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 657310005953 active site 657310005954 active pocket/dimerization site; other site 657310005955 phosphorylation site [posttranslational modification] 657310005956 PRD domain; Region: PRD; pfam00874 657310005957 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 657310005958 catalytic core [active] 657310005959 amidase; Provisional; Region: PRK06529 657310005960 Amidase; Region: Amidase; cl11426 657310005961 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 657310005962 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 657310005963 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 657310005964 FtsX-like permease family; Region: FtsX; pfam02687 657310005965 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 657310005966 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 657310005967 Walker A/P-loop; other site 657310005968 ATP binding site [chemical binding]; other site 657310005969 Q-loop/lid; other site 657310005970 ABC transporter signature motif; other site 657310005971 Walker B; other site 657310005972 D-loop; other site 657310005973 H-loop/switch region; other site 657310005974 HlyD family secretion protein; Region: HlyD_2; pfam12700 657310005975 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 657310005976 active site residue [active] 657310005977 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 657310005978 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 657310005979 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 657310005980 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 657310005981 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 657310005982 active site residue [active] 657310005983 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 657310005984 active site residue [active] 657310005985 Uncharacterized protein YrkD from Bacillus subtilis and related domains; this domain superfamily was previously known as part of DUF156; Region: BsYrkD-like_DUF156; cd10155 657310005986 putative homodimer interface [polypeptide binding]; other site 657310005987 putative homotetramer interface [polypeptide binding]; other site 657310005988 putative metal binding site [ion binding]; other site 657310005989 putative homodimer-homodimer interface [polypeptide binding]; other site 657310005990 putative allosteric switch controlling residues; other site 657310005991 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 657310005992 D-galactonate transporter; Region: 2A0114; TIGR00893 657310005993 putative substrate translocation pore; other site 657310005994 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 657310005995 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 657310005996 catalytic residue [active] 657310005997 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 657310005998 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 657310005999 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 657310006000 putative allantoin catabolism protein; Region: ura-cupin; TIGR03214 657310006001 Protein of unknown function (DUF861); Region: Cupin_3; cl17594 657310006002 Cupin domain; Region: Cupin_2; cl17218 657310006003 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 657310006004 active site 657310006005 metal binding site [ion binding]; metal-binding site 657310006006 dimer interface [polypeptide binding]; other site 657310006007 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 657310006008 allantoinase; Provisional; Region: PRK08044 657310006009 L-Hydantoinases (L-HYDs) and Allantoinase (ALN); L-Hydantoinases are a member of the dihydropyrimidinase family, which catalyzes the reversible hydrolytic ring opening of dihydropyrimidines and hydantoins (five-membered cyclic diamides used in...; Region: L-HYD_ALN; cd01315 657310006010 active site 657310006011 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 657310006012 Na binding site [ion binding]; other site 657310006013 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 657310006014 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 657310006015 Coenzyme A binding pocket [chemical binding]; other site 657310006016 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 657310006017 Sulfate transporter family; Region: Sulfate_transp; pfam00916 657310006018 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 657310006019 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 657310006020 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 657310006021 active site 657310006022 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 657310006023 beta-galactosidase; Region: BGL; TIGR03356 657310006024 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 657310006025 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 657310006026 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 657310006027 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 657310006028 DNA binding residues [nucleotide binding] 657310006029 dimer interface [polypeptide binding]; other site 657310006030 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915 657310006031 Cl- selectivity filter; other site 657310006032 Cl- binding residues [ion binding]; other site 657310006033 pore gating glutamate residue; other site 657310006034 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 657310006035 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 657310006036 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 657310006037 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 657310006038 HsdM N-terminal domain; Region: HsdM_N; pfam12161 657310006039 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 657310006040 Methyltransferase domain; Region: Methyltransf_26; pfam13659 657310006041 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 657310006042 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 657310006043 DRTGG domain; Region: DRTGG; pfam07085 657310006044 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 657310006045 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 657310006046 Protein of unknown function (DUF2877); Region: DUF2877; pfam11392 657310006047 CoA binding domain; Region: CoA_binding; pfam02629 657310006048 CoA-ligase; Region: Ligase_CoA; pfam00549 657310006049 Protein of unknown function (DUF1116); Region: DUF1116; pfam06545 657310006050 Mga helix-turn-helix domain; Region: Mga; pfam05043 657310006051 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 657310006052 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 657310006053 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 657310006054 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 657310006055 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 657310006056 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 657310006057 Soluble P-type ATPase [General function prediction only]; Region: COG4087 657310006058 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 657310006059 serine/threonine transporter SstT; Provisional; Region: PRK13628 657310006060 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 657310006061 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 657310006062 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 657310006063 dimerization interface 3.5A [polypeptide binding]; other site 657310006064 active site 657310006065 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 657310006066 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 657310006067 DNA binding residues [nucleotide binding] 657310006068 DinB superfamily; Region: DinB_2; pfam12867 657310006069 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 657310006070 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 657310006071 protein binding site [polypeptide binding]; other site 657310006072 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 657310006073 putative tRNA-binding site [nucleotide binding]; other site 657310006074 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 657310006075 Ligand Binding Site [chemical binding]; other site 657310006076 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 657310006077 catalytic residues [active] 657310006078 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 657310006079 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 657310006080 oligomer interface [polypeptide binding]; other site 657310006081 active site 657310006082 metal binding site [ion binding]; metal-binding site 657310006083 Predicted small secreted protein [Function unknown]; Region: COG5584 657310006084 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 657310006085 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 657310006086 peptide binding site [polypeptide binding]; other site 657310006087 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 657310006088 PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609 657310006089 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 657310006090 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 657310006091 active site 657310006092 dimer interface [polypeptide binding]; other site 657310006093 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 657310006094 active site 657310006095 phosphorylation site [posttranslational modification] 657310006096 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 657310006097 active pocket/dimerization site; other site 657310006098 active site 657310006099 phosphorylation site [posttranslational modification] 657310006100 Acyltransferase family; Region: Acyl_transf_3; pfam01757 657310006101 Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803 657310006102 putative active site [active] 657310006103 YdjC motif; other site 657310006104 Mg binding site [ion binding]; other site 657310006105 putative homodimer interface [polypeptide binding]; other site 657310006106 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 657310006107 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 657310006108 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 657310006109 putative active site [active] 657310006110 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 657310006111 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 657310006112 putative active site [active] 657310006113 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 657310006114 Predicted membrane protein [Function unknown]; Region: COG3212 657310006115 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 657310006116 Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165 657310006117 active site 657310006118 catalytic site [active] 657310006119 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 657310006120 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 657310006121 rod shape-determining protein MreD; Region: shape_MreD; TIGR03426 657310006122 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 657310006123 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 657310006124 RNase E interface [polypeptide binding]; other site 657310006125 trimer interface [polypeptide binding]; other site 657310006126 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 657310006127 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 657310006128 RNase E interface [polypeptide binding]; other site 657310006129 trimer interface [polypeptide binding]; other site 657310006130 active site 657310006131 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 657310006132 putative nucleic acid binding region [nucleotide binding]; other site 657310006133 G-X-X-G motif; other site 657310006134 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 657310006135 RNA binding site [nucleotide binding]; other site 657310006136 domain interface; other site 657310006137 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 657310006138 16S/18S rRNA binding site [nucleotide binding]; other site 657310006139 S13e-L30e interaction site [polypeptide binding]; other site 657310006140 25S rRNA binding site [nucleotide binding]; other site 657310006141 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 657310006142 active site 657310006143 catalytic residues [active] 657310006144 metal binding site [ion binding]; metal-binding site 657310006145 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 657310006146 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 657310006147 active site 657310006148 motif I; other site 657310006149 motif II; other site 657310006150 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 657310006151 active site 657310006152 motif I; other site 657310006153 motif II; other site 657310006154 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 657310006155 A new structural DNA glycosylase containing HEAT-like repeats; Region: AlkD_like_1; cd07064 657310006156 active site 657310006157 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927 657310006158 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 657310006159 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 657310006160 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 657310006161 RNA binding surface [nucleotide binding]; other site 657310006162 BioY family; Region: BioY; pfam02632 657310006163 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 657310006164 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462 657310006165 Catalytic site [active] 657310006166 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 657310006167 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 657310006168 peptidase T; Region: peptidase-T; TIGR01882 657310006169 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 657310006170 metal binding site [ion binding]; metal-binding site 657310006171 dimer interface [polypeptide binding]; other site 657310006172 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 657310006173 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 657310006174 peptide binding site [polypeptide binding]; other site 657310006175 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 657310006176 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 657310006177 putative ligand binding residues [chemical binding]; other site 657310006178 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 657310006179 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 657310006180 Walker A/P-loop; other site 657310006181 ATP binding site [chemical binding]; other site 657310006182 Q-loop/lid; other site 657310006183 ABC transporter signature motif; other site 657310006184 Walker B; other site 657310006185 D-loop; other site 657310006186 H-loop/switch region; other site 657310006187 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 657310006188 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 657310006189 ABC-ATPase subunit interface; other site 657310006190 dimer interface [polypeptide binding]; other site 657310006191 putative PBP binding regions; other site 657310006192 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 657310006193 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 657310006194 ABC-ATPase subunit interface; other site 657310006195 dimer interface [polypeptide binding]; other site 657310006196 putative PBP binding regions; other site 657310006197 Protein of unknown function (DUF1694); Region: DUF1694; pfam07997 657310006198 glutamate--cysteine ligase/gamma-glutamylcysteine synthetase, Streptococcus agalactiae type; Region: glu_cys_lig_rel; TIGR01435 657310006199 Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352 657310006200 ATP-grasp domain; Region: ATP-grasp_4; cl17255 657310006201 Uncharacterized conserved protein [Function unknown]; Region: COG1284 657310006202 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 657310006203 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 657310006204 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 657310006205 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 657310006206 Cupin superfamily (DUF985); Region: Cupin_5; pfam06172 657310006207 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 657310006208 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 657310006209 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 657310006210 P loop; other site 657310006211 GTP binding site [chemical binding]; other site 657310006212 ribonuclease III; Reviewed; Region: rnc; PRK00102 657310006213 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 657310006214 dimerization interface [polypeptide binding]; other site 657310006215 active site 657310006216 metal binding site [ion binding]; metal-binding site 657310006217 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 657310006218 dsRNA binding site [nucleotide binding]; other site 657310006219 The substrate binding component of an ABC-type lactococcal OppA-like transport system contains; Region: PBP2_Lactococcal_OppA_like; cd08510 657310006220 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 657310006221 peptide binding site [polypeptide binding]; other site 657310006222 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SapC; COG4171 657310006223 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 657310006224 dimer interface [polypeptide binding]; other site 657310006225 conserved gate region; other site 657310006226 putative PBP binding loops; other site 657310006227 ABC-ATPase subunit interface; other site 657310006228 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 657310006229 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 657310006230 dimer interface [polypeptide binding]; other site 657310006231 conserved gate region; other site 657310006232 putative PBP binding loops; other site 657310006233 ABC-ATPase subunit interface; other site 657310006234 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 657310006235 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 657310006236 Walker A/P-loop; other site 657310006237 ATP binding site [chemical binding]; other site 657310006238 Q-loop/lid; other site 657310006239 ABC transporter signature motif; other site 657310006240 Walker B; other site 657310006241 D-loop; other site 657310006242 H-loop/switch region; other site 657310006243 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 657310006244 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 657310006245 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 657310006246 Walker A/P-loop; other site 657310006247 ATP binding site [chemical binding]; other site 657310006248 Q-loop/lid; other site 657310006249 ABC transporter signature motif; other site 657310006250 Walker B; other site 657310006251 D-loop; other site 657310006252 H-loop/switch region; other site 657310006253 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 657310006254 putative phosphate acyltransferase; Provisional; Region: PRK05331 657310006255 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 657310006256 Y-family of DNA polymerases; Region: PolY; cl12025 657310006257 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 657310006258 generic binding surface II; other site 657310006259 ssDNA binding site; other site 657310006260 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 657310006261 ATP binding site [chemical binding]; other site 657310006262 putative Mg++ binding site [ion binding]; other site 657310006263 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 657310006264 nucleotide binding region [chemical binding]; other site 657310006265 ATP-binding site [chemical binding]; other site 657310006266 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 657310006267 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 657310006268 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 657310006269 Walker A/P-loop; other site 657310006270 ATP binding site [chemical binding]; other site 657310006271 Q-loop/lid; other site 657310006272 ABC transporter signature motif; other site 657310006273 Walker B; other site 657310006274 D-loop; other site 657310006275 H-loop/switch region; other site 657310006276 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 657310006277 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 657310006278 Thiamine pyrophosphokinase; Region: TPK; cd07995 657310006279 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 657310006280 active site 657310006281 dimerization interface [polypeptide binding]; other site 657310006282 thiamine binding site [chemical binding]; other site 657310006283 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 657310006284 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 657310006285 substrate binding site [chemical binding]; other site 657310006286 hexamer interface [polypeptide binding]; other site 657310006287 metal binding site [ion binding]; metal-binding site 657310006288 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 657310006289 Catalytic domain of Protein Kinases; Region: PKc; cd00180 657310006290 active site 657310006291 ATP binding site [chemical binding]; other site 657310006292 substrate binding site [chemical binding]; other site 657310006293 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 657310006294 substrate binding site [chemical binding]; other site 657310006295 activation loop (A-loop); other site 657310006296 activation loop (A-loop); other site 657310006297 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 657310006298 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 657310006299 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 657310006300 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 657310006301 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 657310006302 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 657310006303 16S rRNA methyltransferase B; Provisional; Region: PRK14902 657310006304 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 657310006305 putative RNA binding site [nucleotide binding]; other site 657310006306 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 657310006307 S-adenosylmethionine binding site [chemical binding]; other site 657310006308 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 657310006309 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 657310006310 putative active site [active] 657310006311 substrate binding site [chemical binding]; other site 657310006312 putative cosubstrate binding site; other site 657310006313 catalytic site [active] 657310006314 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 657310006315 substrate binding site [chemical binding]; other site 657310006316 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 657310006317 active site 657310006318 catalytic residues [active] 657310006319 metal binding site [ion binding]; metal-binding site 657310006320 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 657310006321 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 657310006322 ATP binding site [chemical binding]; other site 657310006323 putative Mg++ binding site [ion binding]; other site 657310006324 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 657310006325 nucleotide binding region [chemical binding]; other site 657310006326 ATP-binding site [chemical binding]; other site 657310006327 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 657310006328 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 657310006329 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 657310006330 catalytic site [active] 657310006331 G-X2-G-X-G-K; other site 657310006332 acyl-CoA esterase; Provisional; Region: PRK10673 657310006333 hypothetical protein; Provisional; Region: PRK11820 657310006334 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 657310006335 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 657310006336 Uncharacterized protein conserved in bacteria (DUF2128); Region: DUF2128; pfam09901 657310006337 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 657310006338 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 657310006339 active pocket/dimerization site; other site 657310006340 active site 657310006341 phosphorylation site [posttranslational modification] 657310006342 PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830 657310006343 active site 657310006344 phosphorylation site [posttranslational modification] 657310006345 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 657310006346 PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609 657310006347 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 657310006348 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 657310006349 putative active site [active] 657310006350 metal binding site [ion binding]; metal-binding site 657310006351 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 657310006352 Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_12; cd12177 657310006353 putative ligand binding site [chemical binding]; other site 657310006354 putative NAD binding site [chemical binding]; other site 657310006355 catalytic site [active] 657310006356 Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023 657310006357 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 657310006358 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 657310006359 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 657310006360 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 657310006361 putative active site [active] 657310006362 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 657310006363 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 657310006364 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 657310006365 Walker A/P-loop; other site 657310006366 ATP binding site [chemical binding]; other site 657310006367 Q-loop/lid; other site 657310006368 ABC transporter signature motif; other site 657310006369 Walker B; other site 657310006370 D-loop; other site 657310006371 H-loop/switch region; other site 657310006372 Transcriptional regulators [Transcription]; Region: MarR; COG1846 657310006373 MarR family; Region: MarR_2; pfam12802 657310006374 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 657310006375 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 657310006376 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 657310006377 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 657310006378 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 657310006379 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 657310006380 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 657310006381 WxL domain surface cell wall-binding; Region: WxL; pfam13731 657310006382 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 657310006383 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 657310006384 DNA-binding site [nucleotide binding]; DNA binding site 657310006385 UTRA domain; Region: UTRA; pfam07702 657310006386 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 657310006387 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 657310006388 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 657310006389 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 657310006390 beta-phosphoglucomutase; Region: bPGM; TIGR01990 657310006391 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 657310006392 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 657310006393 motif II; other site 657310006394 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 657310006395 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 657310006396 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 657310006397 active site 657310006398 methionine sulfoxide reductase B; Provisional; Region: PRK00222 657310006399 SelR domain; Region: SelR; pfam01641 657310006400 Maf-like protein; Region: Maf; pfam02545 657310006401 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 657310006402 active site 657310006403 dimer interface [polypeptide binding]; other site 657310006404 DNA mismatch repair enzyme (predicted ATPase) [DNA replication, recombination, and repair]; Region: MutL; COG0323 657310006405 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 657310006406 ATP binding site [chemical binding]; other site 657310006407 Mg2+ binding site [ion binding]; other site 657310006408 G-X-G motif; other site 657310006409 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 657310006410 ATP binding site [chemical binding]; other site 657310006411 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 657310006412 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 657310006413 MutS domain I; Region: MutS_I; pfam01624 657310006414 MutS domain II; Region: MutS_II; pfam05188 657310006415 MutS domain III; Region: MutS_III; pfam05192 657310006416 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 657310006417 Walker A/P-loop; other site 657310006418 ATP binding site [chemical binding]; other site 657310006419 Q-loop/lid; other site 657310006420 ABC transporter signature motif; other site 657310006421 Walker B; other site 657310006422 D-loop; other site 657310006423 H-loop/switch region; other site 657310006424 Protein of unknown function (DUF964); Region: DUF964; cl01483 657310006425 phosphodiesterase; Provisional; Region: PRK12704 657310006426 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 657310006427 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 657310006428 Zn2+ binding site [ion binding]; other site 657310006429 Mg2+ binding site [ion binding]; other site 657310006430 competence damage-inducible protein A; Provisional; Region: PRK00549 657310006431 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 657310006432 putative MPT binding site; other site 657310006433 Competence-damaged protein; Region: CinA; pfam02464 657310006434 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 657310006435 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 657310006436 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 657310006437 putative active site [active] 657310006438 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 657310006439 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 657310006440 Walker A/P-loop; other site 657310006441 ATP binding site [chemical binding]; other site 657310006442 Q-loop/lid; other site 657310006443 ABC transporter signature motif; other site 657310006444 Walker B; other site 657310006445 D-loop; other site 657310006446 H-loop/switch region; other site 657310006447 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 657310006448 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 657310006449 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 657310006450 active site 657310006451 zinc binding site [ion binding]; other site 657310006452 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 657310006453 type 2 lantibiotic, SP_1948 family; Region: lant_SP_1948; TIGR03893 657310006454 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 657310006455 non-specific DNA binding site [nucleotide binding]; other site 657310006456 salt bridge; other site 657310006457 sequence-specific DNA binding site [nucleotide binding]; other site 657310006458 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 657310006459 NADH(P)-binding; Region: NAD_binding_10; pfam13460 657310006460 NAD binding site [chemical binding]; other site 657310006461 substrate binding site [chemical binding]; other site 657310006462 putative active site [active] 657310006463 Predicted transcriptional regulator [Transcription]; Region: COG1959 657310006464 Transcriptional regulator; Region: Rrf2; pfam02082 657310006465 hypothetical protein; Provisional; Region: PRK11770 657310006466 Domain of unknown function (DUF307); Region: DUF307; pfam03733 657310006467 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588 657310006468 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 657310006469 metal binding site [ion binding]; metal-binding site 657310006470 dimer interface [polypeptide binding]; other site 657310006471 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 657310006472 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 657310006473 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 657310006474 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 657310006475 DNA binding residues [nucleotide binding] 657310006476 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 657310006477 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 657310006478 WxL domain surface cell wall-binding; Region: WxL; pfam13731 657310006479 WxL domain surface cell wall-binding; Region: WxL; pfam13731 657310006480 WxL domain surface cell wall-binding; Region: WxL; pfam13731 657310006481 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 657310006482 WxL domain surface cell wall-binding; Region: WxL; pfam13731 657310006483 Isochorismatase family; Region: Isochorismatase; pfam00857 657310006484 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 657310006485 catalytic triad [active] 657310006486 conserved cis-peptide bond; other site 657310006487 antiholin-like protein LrgB; Provisional; Region: PRK04288 657310006488 murein hydrolase regulator LrgA; Provisional; Region: PRK04125 657310006489 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 657310006490 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 657310006491 ABC-type metal ion transport system, permease component [Inorganic ion transport and metabolism]; Region: AbcD; COG2011 657310006492 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 657310006493 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 657310006494 Walker A/P-loop; other site 657310006495 ATP binding site [chemical binding]; other site 657310006496 Q-loop/lid; other site 657310006497 ABC transporter signature motif; other site 657310006498 Walker B; other site 657310006499 D-loop; other site 657310006500 H-loop/switch region; other site 657310006501 OsmC-like protein; Region: OsmC; pfam02566 657310006502 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 657310006503 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 657310006504 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 657310006505 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 657310006506 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 657310006507 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 657310006508 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 657310006509 metal binding site [ion binding]; metal-binding site 657310006510 YodA lipocalin-like domain; Region: YodA; pfam09223 657310006511 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 657310006512 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 657310006513 FMN binding site [chemical binding]; other site 657310006514 active site 657310006515 catalytic residues [active] 657310006516 substrate binding site [chemical binding]; other site 657310006517 inner membrane transport permease; Provisional; Region: PRK15066 657310006518 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 657310006519 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 657310006520 ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263 657310006521 Walker A/P-loop; other site 657310006522 ATP binding site [chemical binding]; other site 657310006523 Q-loop/lid; other site 657310006524 ABC transporter signature motif; other site 657310006525 Walker B; other site 657310006526 D-loop; other site 657310006527 H-loop/switch region; other site 657310006528 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 657310006529 active pocket/dimerization site; other site 657310006530 active site 657310006531 phosphorylation site [posttranslational modification] 657310006532 PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830 657310006533 active site 657310006534 phosphorylation site [posttranslational modification] 657310006535 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 657310006536 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 657310006537 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 657310006538 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 657310006539 Walker A motif; other site 657310006540 ATP binding site [chemical binding]; other site 657310006541 Walker B motif; other site 657310006542 arginine finger; other site 657310006543 Transcriptional antiterminator [Transcription]; Region: COG3933 657310006544 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 657310006545 active pocket/dimerization site; other site 657310006546 active site 657310006547 phosphorylation site [posttranslational modification] 657310006548 PRD domain; Region: PRD; pfam00874 657310006549 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 657310006550 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 657310006551 active site 657310006552 8-oxo-dGMP binding site [chemical binding]; other site 657310006553 nudix motif; other site 657310006554 metal binding site [ion binding]; metal-binding site 657310006555 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 657310006556 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3421 657310006557 ATP binding site [chemical binding]; other site 657310006558 putative Mg++ binding site [ion binding]; other site 657310006559 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 657310006560 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 657310006561 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 657310006562 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 657310006563 dimerization interface [polypeptide binding]; other site 657310006564 DPS ferroxidase diiron center [ion binding]; other site 657310006565 ion pore; other site 657310006566 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 657310006567 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 657310006568 N- and C-terminal domain interface [polypeptide binding]; other site 657310006569 active site 657310006570 catalytic site [active] 657310006571 metal binding site [ion binding]; metal-binding site 657310006572 carbohydrate binding site [chemical binding]; other site 657310006573 ATP binding site [chemical binding]; other site 657310006574 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 657310006575 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 657310006576 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 657310006577 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 657310006578 Walker A/P-loop; other site 657310006579 ATP binding site [chemical binding]; other site 657310006580 Q-loop/lid; other site 657310006581 ABC transporter signature motif; other site 657310006582 Walker B; other site 657310006583 D-loop; other site 657310006584 H-loop/switch region; other site 657310006585 Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082); Region: DUF2082; pfam09855 657310006586 Biotin operon repressor [Transcription]; Region: BirA; COG1654 657310006587 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 657310006588 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 657310006589 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 657310006590 Chitin binding domain; Region: Chitin_bind_3; pfam03067 657310006591 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 657310006592 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 657310006593 active site 657310006594 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 657310006595 WxL domain surface cell wall-binding; Region: WxL; pfam13731 657310006596 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Provisional; Region: PRK13387 657310006597 UbiA prenyltransferase family; Region: UbiA; pfam01040 657310006598 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 657310006599 ApbE family; Region: ApbE; pfam02424 657310006600 This conserved region includes the FMN-binding site of the NqrC protein as well as the NosR and NirI regulatory proteins; Region: FMN_bind; smart00900 657310006601 FMN-binding domain; Region: FMN_bind; pfam04205 657310006602 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 657310006603 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 657310006604 Listerrria innocua Lin0431 is similar to the N-Utilization Substance G (NusG) N terminal (NGN) insert (DII); Region: Lin0431_like; cd09911 657310006605 trimer interface [polypeptide binding]; other site 657310006606 Heptaprenyl diphosphate synthase component I; Region: Hpre_diP_synt_I; pfam07456 657310006607 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 657310006608 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 657310006609 substrate binding pocket [chemical binding]; other site 657310006610 chain length determination region; other site 657310006611 substrate-Mg2+ binding site; other site 657310006612 catalytic residues [active] 657310006613 aspartate-rich region 1; other site 657310006614 active site lid residues [active] 657310006615 aspartate-rich region 2; other site 657310006616 dihydropteroate synthase; Region: DHPS; TIGR01496 657310006617 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 657310006618 substrate binding pocket [chemical binding]; other site 657310006619 dimer interface [polypeptide binding]; other site 657310006620 inhibitor binding site; inhibition site 657310006621 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 657310006622 active site 657310006623 dimerization interface [polypeptide binding]; other site 657310006624 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 657310006625 GTP cyclohydrolase I; Provisional; Region: PLN03044 657310006626 active site 657310006627 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 657310006628 catalytic center binding site [active] 657310006629 ATP binding site [chemical binding]; other site 657310006630 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 657310006631 homooctamer interface [polypeptide binding]; other site 657310006632 active site 657310006633 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 657310006634 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 657310006635 non-specific DNA binding site [nucleotide binding]; other site 657310006636 salt bridge; other site 657310006637 sequence-specific DNA binding site [nucleotide binding]; other site 657310006638 glutathione-disulfide reductase, animal/bacterial; Region: gluta_reduc_1; TIGR01421 657310006639 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 657310006640 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 657310006641 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 657310006642 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 657310006643 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 657310006644 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 657310006645 Uncharacterized conserved protein [Function unknown]; Region: COG3535 657310006646 Purine-cytosine permease and related proteins [Nucleotide transport and metabolism]; Region: CodB; COG1457 657310006647 Na binding site [ion binding]; other site 657310006648 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 657310006649 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 657310006650 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 657310006651 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 657310006652 Peptidase family U32; Region: Peptidase_U32; pfam01136 657310006653 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 657310006654 Peptidase family U32; Region: Peptidase_U32; pfam01136 657310006655 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 657310006656 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 657310006657 Clp amino terminal domain; Region: Clp_N; pfam02861 657310006658 Clp amino terminal domain; Region: Clp_N; pfam02861 657310006659 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 657310006660 Walker A motif; other site 657310006661 ATP binding site [chemical binding]; other site 657310006662 Walker B motif; other site 657310006663 arginine finger; other site 657310006664 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 657310006665 Walker A motif; other site 657310006666 ATP binding site [chemical binding]; other site 657310006667 Walker B motif; other site 657310006668 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 657310006669 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848 657310006670 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 657310006671 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 657310006672 homodimer interface [polypeptide binding]; other site 657310006673 substrate-cofactor binding pocket; other site 657310006674 pyridoxal 5'-phosphate binding site [chemical binding]; other site 657310006675 catalytic residue [active] 657310006676 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 657310006677 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 657310006678 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 657310006679 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 657310006680 Host cell surface-exposed lipoprotein; Region: Lipoprotein_Ltp; pfam07553 657310006681 Host cell surface-exposed lipoprotein; Region: Lipoprotein_Ltp; pfam07553 657310006682 multiple promoter invertase; Provisional; Region: mpi; PRK13413 657310006683 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 657310006684 catalytic residues [active] 657310006685 catalytic nucleophile [active] 657310006686 Presynaptic Site I dimer interface [polypeptide binding]; other site 657310006687 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 657310006688 Synaptic Flat tetramer interface [polypeptide binding]; other site 657310006689 Synaptic Site I dimer interface [polypeptide binding]; other site 657310006690 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 657310006691 DNA-binding interface [nucleotide binding]; DNA binding site 657310006692 putative transposase OrfB; Reviewed; Region: PHA02517 657310006693 HTH-like domain; Region: HTH_21; pfam13276 657310006694 Integrase core domain; Region: rve; pfam00665 657310006695 Integrase core domain; Region: rve_3; pfam13683 657310006696 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 657310006697 Transposase; Region: HTH_Tnp_1; pfam01527 657310006698 Bacterial mobilisation protein (MobC); Region: MobC; pfam05713 657310006699 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 657310006700 probable regulatory domain; Region: near_KaiC_dom; TIGR03879 657310006701 Uncharacterized conserved protein [Function unknown]; Region: COG1359 657310006702 pyruvate, phosphate dikinase; Region: pyru_phos_dikin; TIGR01828 657310006703 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 657310006704 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 657310006705 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 657310006706 HTH domain; Region: HTH_11; pfam08279 657310006707 FOG: CBS domain [General function prediction only]; Region: COG0517 657310006708 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617 657310006709 Kinase/pyrophosphorylase; Region: Kinase-PPPase; pfam03618 657310006710 Predicted integral membrane protein [Function unknown]; Region: COG0392 657310006711 Uncharacterized conserved protein [Function unknown]; Region: COG2898 657310006712 Keratinocyte-associated protein 2; Region: Keratin_assoc; pfam09775 657310006713 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 657310006714 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 657310006715 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 657310006716 AAA domain; Region: AAA_17; cl17253 657310006717 AAA domain; Region: AAA_18; pfam13238 657310006718 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 657310006719 Walker A/P-loop; other site 657310006720 ATP binding site [chemical binding]; other site 657310006721 Q-loop/lid; other site 657310006722 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 657310006723 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 657310006724 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 657310006725 Walker A/P-loop; other site 657310006726 ATP binding site [chemical binding]; other site 657310006727 Q-loop/lid; other site 657310006728 ABC transporter signature motif; other site 657310006729 Walker B; other site 657310006730 D-loop; other site 657310006731 H-loop/switch region; other site 657310006732 Amidase; Region: Amidase; cl11426 657310006733 Phosphotransferase enzyme family; Region: APH; pfam01636 657310006734 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 657310006735 active site 657310006736 ATP binding site [chemical binding]; other site 657310006737 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 657310006738 active site 657310006739 multimer interface [polypeptide binding]; other site 657310006740 aspartate 4-decarboxylase; Region: asp_4_decarbox; TIGR03801 657310006741 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 657310006742 pyridoxal 5'-phosphate binding site [chemical binding]; other site 657310006743 homodimer interface [polypeptide binding]; other site 657310006744 catalytic residue [active] 657310006745 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 657310006746 drug efflux system protein MdtG; Provisional; Region: PRK09874 657310006747 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 657310006748 putative substrate translocation pore; other site 657310006749 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 657310006750 DNA polymerase III DnaE; Validated; Region: dnaE; PRK07135 657310006751 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 657310006752 active site 657310006753 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 657310006754 generic binding surface I; other site 657310006755 generic binding surface II; other site 657310006756 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 657310006757 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 657310006758 active site 657310006759 ADP/pyrophosphate binding site [chemical binding]; other site 657310006760 dimerization interface [polypeptide binding]; other site 657310006761 allosteric effector site; other site 657310006762 fructose-1,6-bisphosphate binding site; other site 657310006763 pyruvate kinase; Provisional; Region: PRK06354 657310006764 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 657310006765 domain interfaces; other site 657310006766 active site 657310006767 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 657310006768 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 657310006769 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 657310006770 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 657310006771 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 657310006772 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 657310006773 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 657310006774 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 657310006775 active site 657310006776 phosphorylation site [posttranslational modification] 657310006777 intermolecular recognition site; other site 657310006778 dimerization interface [polypeptide binding]; other site 657310006779 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 657310006780 DNA binding site [nucleotide binding] 657310006781 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 657310006782 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 657310006783 dimerization interface [polypeptide binding]; other site 657310006784 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 657310006785 dimer interface [polypeptide binding]; other site 657310006786 phosphorylation site [posttranslational modification] 657310006787 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 657310006788 ATP binding site [chemical binding]; other site 657310006789 Mg2+ binding site [ion binding]; other site 657310006790 G-X-G motif; other site