-- dump date 20140619_073845 -- class Genbank::misc_feature -- table misc_feature_note -- id note 565655000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 565655000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 565655000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 565655000004 Walker A motif; other site 565655000005 ATP binding site [chemical binding]; other site 565655000006 Walker B motif; other site 565655000007 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 565655000008 arginine finger; other site 565655000009 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 565655000010 DnaA box-binding interface [nucleotide binding]; other site 565655000011 DNA polymerase III subunit beta; Validated; Region: PRK05643 565655000012 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 565655000013 putative DNA binding surface [nucleotide binding]; other site 565655000014 dimer interface [polypeptide binding]; other site 565655000015 beta-clamp/clamp loader binding surface; other site 565655000016 beta-clamp/translesion DNA polymerase binding surface; other site 565655000017 S4 domain protein YaaA; Region: YaaA_near_RecF; TIGR02988 565655000018 recombination protein F; Reviewed; Region: recF; PRK00064 565655000019 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 565655000020 Walker A/P-loop; other site 565655000021 ATP binding site [chemical binding]; other site 565655000022 Q-loop/lid; other site 565655000023 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 565655000024 ABC transporter signature motif; other site 565655000025 Walker B; other site 565655000026 D-loop; other site 565655000027 H-loop/switch region; other site 565655000028 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 565655000029 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 565655000030 Mg2+ binding site [ion binding]; other site 565655000031 G-X-G motif; other site 565655000032 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 565655000033 anchoring element; other site 565655000034 dimer interface [polypeptide binding]; other site 565655000035 ATP binding site [chemical binding]; other site 565655000036 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 565655000037 active site 565655000038 putative metal-binding site [ion binding]; other site 565655000039 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 565655000040 DNA gyrase subunit A; Validated; Region: PRK05560 565655000041 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 565655000042 CAP-like domain; other site 565655000043 active site 565655000044 primary dimer interface [polypeptide binding]; other site 565655000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 565655000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 565655000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 565655000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 565655000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 565655000050 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 565655000051 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 565655000052 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 565655000053 dimer interface [polypeptide binding]; other site 565655000054 ssDNA binding site [nucleotide binding]; other site 565655000055 tetramer (dimer of dimers) interface [polypeptide binding]; other site 565655000056 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 565655000057 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 565655000058 Divergent AAA domain; Region: AAA_4; pfam04326 565655000059 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 565655000060 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 565655000061 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 565655000062 DHH family; Region: DHH; pfam01368 565655000063 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 565655000064 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 565655000065 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 565655000066 replicative DNA helicase; Provisional; Region: PRK05748 565655000067 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 565655000068 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 565655000069 Walker A motif; other site 565655000070 ATP binding site [chemical binding]; other site 565655000071 Walker B motif; other site 565655000072 DNA binding loops [nucleotide binding] 565655000073 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 565655000074 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 565655000075 GDP-binding site [chemical binding]; other site 565655000076 ACT binding site; other site 565655000077 IMP binding site; other site 565655000078 EDD domain protein, DegV family; Region: DegV; TIGR00762 565655000079 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 565655000080 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 565655000081 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 565655000082 Walker A/P-loop; other site 565655000083 ATP binding site [chemical binding]; other site 565655000084 Q-loop/lid; other site 565655000085 ABC transporter signature motif; other site 565655000086 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 565655000087 Walker B; other site 565655000088 D-loop; other site 565655000089 H-loop/switch region; other site 565655000090 ABC transporter; Region: ABC_tran_2; pfam12848 565655000091 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 565655000092 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 565655000093 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 565655000094 putative catalytic cysteine [active] 565655000095 gamma-glutamyl kinase; Provisional; Region: PRK05429 565655000096 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 565655000097 nucleotide binding site [chemical binding]; other site 565655000098 homotetrameric interface [polypeptide binding]; other site 565655000099 putative phosphate binding site [ion binding]; other site 565655000100 putative allosteric binding site; other site 565655000101 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 565655000102 trimer interface [polypeptide binding]; other site 565655000103 active site 565655000104 DNA repair protein RadA; Provisional; Region: PRK11823 565655000105 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 565655000106 Walker A motif/ATP binding site; other site 565655000107 ATP binding site [chemical binding]; other site 565655000108 Walker B motif; other site 565655000109 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 565655000110 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 565655000111 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 565655000112 putative active site [active] 565655000113 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 565655000114 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 565655000115 HIGH motif; other site 565655000116 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 565655000117 active site 565655000118 KMSKS motif; other site 565655000119 serine O-acetyltransferase; Region: cysE; TIGR01172 565655000120 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 565655000121 trimer interface [polypeptide binding]; other site 565655000122 active site 565655000123 substrate binding site [chemical binding]; other site 565655000124 CoA binding site [chemical binding]; other site 565655000125 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 565655000126 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 565655000127 active site 565655000128 HIGH motif; other site 565655000129 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 565655000130 KMSKS motif; other site 565655000131 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 565655000132 tRNA binding surface [nucleotide binding]; other site 565655000133 anticodon binding site; other site 565655000134 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 565655000135 active site 565655000136 metal binding site [ion binding]; metal-binding site 565655000137 dimerization interface [polypeptide binding]; other site 565655000138 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 565655000139 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 565655000140 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 565655000141 YacP-like NYN domain; Region: NYN_YacP; pfam05991 565655000142 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 565655000143 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 565655000144 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 565655000145 Coenzyme A binding pocket [chemical binding]; other site 565655000146 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 565655000147 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 565655000148 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 565655000149 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 565655000150 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 565655000151 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 565655000152 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 565655000153 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 565655000154 Helix-turn-helix domain; Region: HTH_25; pfam13413 565655000155 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 565655000156 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 565655000157 competence damage-inducible protein A; Provisional; Region: PRK00549 565655000158 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 565655000159 putative MPT binding site; other site 565655000160 Competence-damaged protein; Region: CinA; pfam02464 565655000161 recombinase A; Provisional; Region: recA; PRK09354 565655000162 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 565655000163 hexamer interface [polypeptide binding]; other site 565655000164 Walker A motif; other site 565655000165 ATP binding site [chemical binding]; other site 565655000166 Walker B motif; other site 565655000167 phosphodiesterase; Provisional; Region: PRK12704 565655000168 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 565655000169 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 565655000170 Zn2+ binding site [ion binding]; other site 565655000171 Mg2+ binding site [ion binding]; other site 565655000172 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 565655000173 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 565655000174 DNA-binding site [nucleotide binding]; DNA binding site 565655000175 UTRA domain; Region: UTRA; pfam07702 565655000176 beta-phosphoglucomutase; Region: bPGM; TIGR01990 565655000177 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 565655000178 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 565655000179 motif II; other site 565655000180 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 565655000181 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 565655000182 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 565655000183 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 565655000184 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 565655000185 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 565655000186 active site turn [active] 565655000187 phosphorylation site [posttranslational modification] 565655000188 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 565655000189 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 565655000190 HPr interaction site; other site 565655000191 glycerol kinase (GK) interaction site [polypeptide binding]; other site 565655000192 active site 565655000193 phosphorylation site [posttranslational modification] 565655000194 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 565655000195 Major Facilitator Superfamily; Region: MFS_1; pfam07690 565655000196 putative substrate translocation pore; other site 565655000197 Predicted membrane protein [Function unknown]; Region: COG4709 565655000198 Predicted transcriptional regulators [Transcription]; Region: COG1695 565655000199 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 565655000200 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 565655000201 WHG domain; Region: WHG; pfam13305 565655000202 HAMP domain; Region: HAMP; pfam00672 565655000203 Histidine kinase; Region: His_kinase; pfam06580 565655000204 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 565655000205 ATP binding site [chemical binding]; other site 565655000206 Mg2+ binding site [ion binding]; other site 565655000207 G-X-G motif; other site 565655000208 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 565655000209 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 565655000210 active site 565655000211 phosphorylation site [posttranslational modification] 565655000212 intermolecular recognition site; other site 565655000213 dimerization interface [polypeptide binding]; other site 565655000214 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 565655000215 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 565655000216 CrcB-like protein; Region: CRCB; cl09114 565655000217 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 565655000218 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 565655000219 dimer interface [polypeptide binding]; other site 565655000220 conserved gate region; other site 565655000221 ABC-ATPase subunit interface; other site 565655000222 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 565655000223 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 565655000224 dimer interface [polypeptide binding]; other site 565655000225 conserved gate region; other site 565655000226 ABC-ATPase subunit interface; other site 565655000227 pullulanase, type I; Region: pulA_typeI; TIGR02104 565655000228 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 565655000229 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 565655000230 Ca binding site [ion binding]; other site 565655000231 active site 565655000232 catalytic site [active] 565655000233 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 565655000234 beta-galactosidase; Region: BGL; TIGR03356 565655000235 Protein of unknown function (DUF419); Region: DUF419; pfam04237 565655000236 YwpF-like protein; Region: YwpF; pfam14183 565655000237 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 565655000238 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 565655000239 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 565655000240 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 565655000241 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 565655000242 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 565655000243 beta-galactosidase; Region: BGL; TIGR03356 565655000244 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 565655000245 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 565655000246 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 565655000247 Walker A/P-loop; other site 565655000248 ATP binding site [chemical binding]; other site 565655000249 Q-loop/lid; other site 565655000250 ABC transporter signature motif; other site 565655000251 Walker B; other site 565655000252 D-loop; other site 565655000253 H-loop/switch region; other site 565655000254 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 565655000255 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 565655000256 non-specific DNA binding site [nucleotide binding]; other site 565655000257 salt bridge; other site 565655000258 sequence-specific DNA binding site [nucleotide binding]; other site 565655000259 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 565655000260 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 565655000261 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 565655000262 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 565655000263 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 565655000264 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 565655000265 Walker A/P-loop; other site 565655000266 ATP binding site [chemical binding]; other site 565655000267 Q-loop/lid; other site 565655000268 ABC transporter signature motif; other site 565655000269 Walker B; other site 565655000270 D-loop; other site 565655000271 H-loop/switch region; other site 565655000272 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 565655000273 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 565655000274 ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247 565655000275 Walker A/P-loop; other site 565655000276 ATP binding site [chemical binding]; other site 565655000277 Q-loop/lid; other site 565655000278 ABC transporter signature motif; other site 565655000279 Walker B; other site 565655000280 D-loop; other site 565655000281 H-loop/switch region; other site 565655000282 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 565655000283 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 565655000284 substrate binding pocket [chemical binding]; other site 565655000285 chain length determination region; other site 565655000286 substrate-Mg2+ binding site; other site 565655000287 catalytic residues [active] 565655000288 aspartate-rich region 1; other site 565655000289 active site lid residues [active] 565655000290 aspartate-rich region 2; other site 565655000291 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 565655000292 UbiA prenyltransferase family; Region: UbiA; pfam01040 565655000293 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 565655000294 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 565655000295 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 565655000296 ApbE family; Region: ApbE; pfam02424 565655000297 Transcriptional regulator [Transcription]; Region: LysR; COG0583 565655000298 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 565655000299 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 565655000300 dimerization interface [polypeptide binding]; other site 565655000301 Predicted flavoprotein [General function prediction only]; Region: COG0431 565655000302 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 565655000303 Predicted flavoprotein [General function prediction only]; Region: COG0431 565655000304 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 565655000305 FMN-binding domain; Region: FMN_bind; pfam04205 565655000306 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 565655000307 L-aspartate oxidase; Provisional; Region: PRK06175 565655000308 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 565655000309 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 565655000310 putative substrate translocation pore; other site 565655000311 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 565655000312 Bacterial SH3 domain; Region: SH3_3; cl17532 565655000313 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 565655000314 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 565655000315 Heat induced stress protein YflT; Region: YflT; pfam11181 565655000316 phosphate-starvation-inducible protein PsiE; Provisional; Region: PRK02833 565655000317 Firmicute fructose-1,6-bisphosphatase; Region: FBPase_2; pfam06874 565655000318 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 565655000319 Kinase/pyrophosphorylase; Region: Kinase-PPPase; pfam03618 565655000320 HTH domain; Region: HTH_11; pfam08279 565655000321 FOG: CBS domain [General function prediction only]; Region: COG0517 565655000322 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 565655000323 pyruvate phosphate dikinase; Provisional; Region: PRK09279 565655000324 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 565655000325 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 565655000326 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 565655000327 Protein of unknown function (DUF454); Region: DUF454; cl01063 565655000328 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 565655000329 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 565655000330 active site 565655000331 catalytic tetrad [active] 565655000332 Cache domain; Region: Cache_1; pfam02743 565655000333 gliding motility-associated protein GldL; Region: GldL_gliding; TIGR03513 565655000334 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 565655000335 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 565655000336 dimer interface [polypeptide binding]; other site 565655000337 putative CheW interface [polypeptide binding]; other site 565655000338 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 565655000339 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 565655000340 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 565655000341 ligand binding site [chemical binding]; other site 565655000342 flagellar motor protein MotA; Validated; Region: PRK08124 565655000343 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 565655000344 flagellar basal-body rod protein FlgB; Region: FlgB; TIGR01396 565655000345 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 565655000346 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 565655000347 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 565655000348 Flagellar hook-basal body complex protein FliE; Region: FliE; pfam02049 565655000349 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 565655000350 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 565655000351 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 565655000352 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 565655000353 FliG C-terminal domain; Region: FliG_C; pfam01706 565655000354 flagellar protein export ATPase FliI; Region: FliI_clade2; TIGR03497 565655000355 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 565655000356 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 565655000357 Walker A motif/ATP binding site; other site 565655000358 Walker B motif; other site 565655000359 Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882 565655000360 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 565655000361 flagellar basal body rod modification protein; Provisional; Region: flgD; PRK09618 565655000362 Protein of unknown function (DUF3766); Region: DUF3766; cl11797 565655000363 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12636 565655000364 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 565655000365 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 565655000366 Flagellar protein (FlbD); Region: FlbD; pfam06289 565655000367 Flagellar basal body-associated protein FliL; Region: FliL; pfam03748 565655000368 Flagellar biosynthesis protein, FliO; Region: FliO; cl01247 565655000369 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 565655000370 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 565655000371 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 565655000372 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 565655000373 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 565655000374 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 565655000375 FHIPEP family; Region: FHIPEP; pfam00771 565655000376 RNA polymerase sigma factor, FliA/WhiG family; Region: FliA_WhiG; TIGR02479 565655000377 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 565655000378 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 565655000379 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 565655000380 DNA binding residues [nucleotide binding] 565655000381 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12818 565655000382 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 565655000383 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 565655000384 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 565655000385 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 565655000386 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 565655000387 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 565655000388 Walker A/P-loop; other site 565655000389 ATP binding site [chemical binding]; other site 565655000390 Q-loop/lid; other site 565655000391 ABC transporter signature motif; other site 565655000392 Walker B; other site 565655000393 D-loop; other site 565655000394 H-loop/switch region; other site 565655000395 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 565655000396 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 565655000397 dimer interface [polypeptide binding]; other site 565655000398 putative CheW interface [polypeptide binding]; other site 565655000399 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588 565655000400 CheD chemotactic sensory transduction; Region: CheD; cl00810 565655000401 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 565655000402 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 565655000403 active site 565655000404 phosphorylation site [posttranslational modification] 565655000405 intermolecular recognition site; other site 565655000406 dimerization interface [polypeptide binding]; other site 565655000407 CheB methylesterase; Region: CheB_methylest; pfam01339 565655000408 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 565655000409 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 565655000410 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 565655000411 S-adenosylmethionine binding site [chemical binding]; other site 565655000412 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 565655000413 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 565655000414 putative binding surface; other site 565655000415 active site 565655000416 P2 response regulator binding domain; Region: P2; pfam07194 565655000417 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 565655000418 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 565655000419 ATP binding site [chemical binding]; other site 565655000420 Mg2+ binding site [ion binding]; other site 565655000421 G-X-G motif; other site 565655000422 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 565655000423 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 565655000424 CheC-like family; Region: CheC; pfam04509 565655000425 Response regulator receiver domain; Region: Response_reg; pfam00072 565655000426 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 565655000427 active site 565655000428 phosphorylation site [posttranslational modification] 565655000429 intermolecular recognition site; other site 565655000430 dimerization interface [polypeptide binding]; other site 565655000431 CheW-like domain; Region: CheW; pfam01584 565655000432 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 565655000433 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 565655000434 flagellar motor switch protein; Validated; Region: PRK08119 565655000435 CheC-like family; Region: CheC; pfam04509 565655000436 CheC-like family; Region: CheC; pfam04509 565655000437 flagellar motor switch protein FliN; Region: fliN; TIGR02480 565655000438 Anti-sigma-28 factor, FlgM; Region: FlgM; pfam04316 565655000439 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739 565655000440 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 565655000441 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK07701 565655000442 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 565655000443 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 565655000444 Flagellin and related hook-associated proteins [Cell motility and secretion]; Region: FlgL; COG1344 565655000445 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 565655000446 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 565655000447 FlaG protein; Region: FlaG; pfam03646 565655000448 Flagellar capping protein [Cell motility and secretion]; Region: FliD; COG1345 565655000449 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 565655000450 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 565655000451 Flagellar protein FliS; Region: FliS; cl00654 565655000452 Uncharacterized protein family (UPF0182); Region: UPF0182; pfam03699 565655000453 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 565655000454 MarR family; Region: MarR_2; pfam12802 565655000455 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 565655000456 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 565655000457 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 565655000458 Walker A/P-loop; other site 565655000459 ATP binding site [chemical binding]; other site 565655000460 Q-loop/lid; other site 565655000461 ABC transporter signature motif; other site 565655000462 Walker B; other site 565655000463 D-loop; other site 565655000464 H-loop/switch region; other site 565655000465 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 565655000466 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 565655000467 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 565655000468 Walker A/P-loop; other site 565655000469 ATP binding site [chemical binding]; other site 565655000470 Q-loop/lid; other site 565655000471 ABC transporter signature motif; other site 565655000472 Walker B; other site 565655000473 D-loop; other site 565655000474 H-loop/switch region; other site 565655000475 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 565655000476 beta-galactosidase; Region: BGL; TIGR03356 565655000477 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 565655000478 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 565655000479 metal-binding site [ion binding] 565655000480 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 565655000481 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 565655000482 metal-binding site [ion binding] 565655000483 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 565655000484 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 565655000485 motif II; other site 565655000486 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 565655000487 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 565655000488 DNA-binding site [nucleotide binding]; DNA binding site 565655000489 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 565655000490 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 565655000491 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 565655000492 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 565655000493 beta-galactosidase; Region: BGL; TIGR03356 565655000494 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 565655000495 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 565655000496 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 565655000497 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 565655000498 DNA-binding site [nucleotide binding]; DNA binding site 565655000499 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 565655000500 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 565655000501 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 565655000502 GIY-YIG motif/motif A; other site 565655000503 active site 565655000504 catalytic site [active] 565655000505 putative DNA binding site [nucleotide binding]; other site 565655000506 metal binding site [ion binding]; metal-binding site 565655000507 UvrB/uvrC motif; Region: UVR; pfam02151 565655000508 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 565655000509 Transcriptional regulator [Transcription]; Region: LysR; COG0583 565655000510 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 565655000511 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 565655000512 dimerization interface [polypeptide binding]; other site 565655000513 Predicted membrane protein [Function unknown]; Region: COG2855 565655000514 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 565655000515 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 565655000516 beta-galactosidase; Region: BGL; TIGR03356 565655000517 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 565655000518 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 565655000519 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 565655000520 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 565655000521 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 565655000522 putative active site [active] 565655000523 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 565655000524 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 565655000525 nucleotide binding site [chemical binding]; other site 565655000526 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 565655000527 putative active site [active] 565655000528 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 565655000529 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 565655000530 Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301 565655000531 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 565655000532 Coenzyme A binding pocket [chemical binding]; other site 565655000533 Transcriptional regulators [Transcription]; Region: GntR; COG1802 565655000534 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 565655000535 DNA-binding site [nucleotide binding]; DNA binding site 565655000536 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 565655000537 phosphonate ABC transporter, ATP-binding protein; Region: ABC_phnC; TIGR02315 565655000538 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 565655000539 Walker A/P-loop; other site 565655000540 ATP binding site [chemical binding]; other site 565655000541 Q-loop/lid; other site 565655000542 ABC transporter signature motif; other site 565655000543 Walker B; other site 565655000544 D-loop; other site 565655000545 H-loop/switch region; other site 565655000546 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 565655000547 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 565655000548 dimer interface [polypeptide binding]; other site 565655000549 conserved gate region; other site 565655000550 ABC-ATPase subunit interface; other site 565655000551 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 565655000552 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 565655000553 dimer interface [polypeptide binding]; other site 565655000554 conserved gate region; other site 565655000555 putative PBP binding loops; other site 565655000556 ABC-ATPase subunit interface; other site 565655000557 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 565655000558 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 565655000559 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 565655000560 Protein of unknown function (DUF1093); Region: DUF1093; cl02185 565655000561 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 565655000562 Protein of unknown function (DUF1761); Region: DUF1761; pfam08570 565655000563 Protein of unknown function, DUF485; Region: DUF485; cl01231 565655000564 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 565655000565 PAS domain; Region: PAS_9; pfam13426 565655000566 putative active site [active] 565655000567 heme pocket [chemical binding]; other site 565655000568 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 565655000569 dimer interface [polypeptide binding]; other site 565655000570 putative CheW interface [polypeptide binding]; other site 565655000571 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 565655000572 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 565655000573 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 565655000574 acetolactate synthase; Reviewed; Region: PRK08617 565655000575 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 565655000576 PYR/PP interface [polypeptide binding]; other site 565655000577 dimer interface [polypeptide binding]; other site 565655000578 TPP binding site [chemical binding]; other site 565655000579 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 565655000580 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 565655000581 TPP-binding site [chemical binding]; other site 565655000582 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306 565655000583 Mga helix-turn-helix domain; Region: Mga; pfam05043 565655000584 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 565655000585 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 565655000586 Peptidase family M23; Region: Peptidase_M23; pfam01551 565655000587 HTH domain; Region: HTH_11; cl17392 565655000588 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 565655000589 Mga helix-turn-helix domain; Region: Mga; pfam05043 565655000590 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 565655000591 phytoene desaturase; Region: crtI_fam; TIGR02734 565655000592 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 565655000593 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 565655000594 active site 565655000595 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 565655000596 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 565655000597 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 565655000598 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 565655000599 DNA binding site [nucleotide binding] 565655000600 active site 565655000601 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 565655000602 MarR family; Region: MarR; pfam01047 565655000603 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 565655000604 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 565655000605 Zn binding site [ion binding]; other site 565655000606 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 565655000607 Zn binding site [ion binding]; other site 565655000608 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 565655000609 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 565655000610 Zn binding site [ion binding]; other site 565655000611 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 565655000612 Zn binding site [ion binding]; other site 565655000613 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 565655000614 putative hydrolase; Provisional; Region: PRK11460 565655000615 Predicted esterase [General function prediction only]; Region: COG0400 565655000616 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 565655000617 active pocket/dimerization site; other site 565655000618 active site 565655000619 phosphorylation site [posttranslational modification] 565655000620 Preprotein translocase subunit; Region: YajC; pfam02699 565655000621 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 565655000622 active site 565655000623 phosphorylation site [posttranslational modification] 565655000624 PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609 565655000625 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 565655000626 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; cl01507 565655000627 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 565655000628 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 565655000629 DNA-binding site [nucleotide binding]; DNA binding site 565655000630 UTRA domain; Region: UTRA; pfam07702 565655000631 putative sugar isomerase, AgaS family; Region: agaS_fam; TIGR02815 565655000632 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 565655000633 dimer interface [polypeptide binding]; other site 565655000634 active site 565655000635 AgaS-like protein. AgaS contains a SIS (Sugar ISomerase) domain which is found in many phosphosugar isomerases and phosphosugar binding proteins. AgaS is a putative isomerase in Escherichia coli. It is similar to the glucosamine-6-phosphate synthases; Region: SIS_AgaS_like; cd05010 565655000636 putative active site [active] 565655000637 tagatose 1,6-diphosphate aldolase; Reviewed; Region: PRK12399 565655000638 Uncharacterized protein conserved in bacteria (DUF2264); Region: DUF2264; pfam10022 565655000639 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 565655000640 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 565655000641 Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301 565655000642 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 565655000643 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 565655000644 DNA-binding site [nucleotide binding]; DNA binding site 565655000645 UTRA domain; Region: UTRA; pfam07702 565655000646 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 565655000647 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 565655000648 active site 565655000649 active pocket/dimerization site; other site 565655000650 phosphorylation site [posttranslational modification] 565655000651 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 565655000652 active site 565655000653 phosphorylation site [posttranslational modification] 565655000654 PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609 565655000655 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 565655000656 GMP synthase; Reviewed; Region: guaA; PRK00074 565655000657 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 565655000658 AMP/PPi binding site [chemical binding]; other site 565655000659 candidate oxyanion hole; other site 565655000660 catalytic triad [active] 565655000661 potential glutamine specificity residues [chemical binding]; other site 565655000662 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 565655000663 ATP Binding subdomain [chemical binding]; other site 565655000664 Dimerization subdomain; other site 565655000665 pantothenate kinase; Provisional; Region: PRK05439 565655000666 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 565655000667 ATP-binding site [chemical binding]; other site 565655000668 CoA-binding site [chemical binding]; other site 565655000669 Mg2+-binding site [ion binding]; other site 565655000670 Methyltransferase domain; Region: Methyltransf_31; pfam13847 565655000671 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 565655000672 S-adenosylmethionine binding site [chemical binding]; other site 565655000673 Transcriptional regulators [Transcription]; Region: PurR; COG1609 565655000674 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 565655000675 DNA binding site [nucleotide binding] 565655000676 domain linker motif; other site 565655000677 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 565655000678 dimerization interface [polypeptide binding]; other site 565655000679 ligand binding site [chemical binding]; other site 565655000680 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 565655000681 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 565655000682 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 565655000683 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 565655000684 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 565655000685 intersubunit interface [polypeptide binding]; other site 565655000686 active site 565655000687 catalytic residue [active] 565655000688 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 565655000689 active site 565655000690 catalytic motif [active] 565655000691 Zn binding site [ion binding]; other site 565655000692 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 565655000693 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 565655000694 ligand binding site [chemical binding]; other site 565655000695 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 565655000696 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 565655000697 Walker A/P-loop; other site 565655000698 ATP binding site [chemical binding]; other site 565655000699 Q-loop/lid; other site 565655000700 ABC transporter signature motif; other site 565655000701 Walker B; other site 565655000702 D-loop; other site 565655000703 H-loop/switch region; other site 565655000704 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 565655000705 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 565655000706 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 565655000707 TM-ABC transporter signature motif; other site 565655000708 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 565655000709 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 565655000710 TM-ABC transporter signature motif; other site 565655000711 phosphopentomutase; Provisional; Region: PRK05362 565655000712 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 565655000713 purine nucleoside phosphorylase; Provisional; Region: PRK08202 565655000714 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 565655000715 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 565655000716 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 565655000717 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 565655000718 dimer interface [polypeptide binding]; other site 565655000719 active site 565655000720 metal binding site [ion binding]; metal-binding site 565655000721 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_2; cd01834 565655000722 active site 565655000723 catalytic triad [active] 565655000724 oxyanion hole [active] 565655000725 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 565655000726 catalytic core [active] 565655000727 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 565655000728 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 565655000729 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 565655000730 catalytic residues [active] 565655000731 catalytic nucleophile [active] 565655000732 Presynaptic Site I dimer interface [polypeptide binding]; other site 565655000733 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 565655000734 Synaptic Flat tetramer interface [polypeptide binding]; other site 565655000735 Synaptic Site I dimer interface [polypeptide binding]; other site 565655000736 DNA binding site [nucleotide binding] 565655000737 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 565655000738 tetramer (dimer of dimers) interface [polypeptide binding]; other site 565655000739 active site 565655000740 dimer interface [polypeptide binding]; other site 565655000741 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 565655000742 S17 interaction site [polypeptide binding]; other site 565655000743 S8 interaction site; other site 565655000744 16S rRNA interaction site [nucleotide binding]; other site 565655000745 streptomycin interaction site [chemical binding]; other site 565655000746 23S rRNA interaction site [nucleotide binding]; other site 565655000747 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 565655000748 30S ribosomal protein S7; Validated; Region: PRK05302 565655000749 elongation factor G; Reviewed; Region: PRK00007 565655000750 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 565655000751 G1 box; other site 565655000752 putative GEF interaction site [polypeptide binding]; other site 565655000753 GTP/Mg2+ binding site [chemical binding]; other site 565655000754 Switch I region; other site 565655000755 G2 box; other site 565655000756 G3 box; other site 565655000757 Switch II region; other site 565655000758 G4 box; other site 565655000759 G5 box; other site 565655000760 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 565655000761 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 565655000762 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 565655000763 elongation factor Tu; Reviewed; Region: PRK00049 565655000764 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 565655000765 G1 box; other site 565655000766 GEF interaction site [polypeptide binding]; other site 565655000767 GTP/Mg2+ binding site [chemical binding]; other site 565655000768 Switch I region; other site 565655000769 G2 box; other site 565655000770 G3 box; other site 565655000771 Switch II region; other site 565655000772 G4 box; other site 565655000773 G5 box; other site 565655000774 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 565655000775 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 565655000776 Antibiotic Binding Site [chemical binding]; other site 565655000777 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 565655000778 dimer interface [polypeptide binding]; other site 565655000779 FMN binding site [chemical binding]; other site 565655000780 NADPH bind site [chemical binding]; other site 565655000781 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 565655000782 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 565655000783 DNA-binding site [nucleotide binding]; DNA binding site 565655000784 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 565655000785 pyridoxal 5'-phosphate binding site [chemical binding]; other site 565655000786 homodimer interface [polypeptide binding]; other site 565655000787 catalytic residue [active] 565655000788 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 565655000789 dimer interface [polypeptide binding]; other site 565655000790 substrate binding site [chemical binding]; other site 565655000791 ATP binding site [chemical binding]; other site 565655000792 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 565655000793 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 565655000794 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 565655000795 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 565655000796 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 565655000797 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 565655000798 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 565655000799 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 565655000800 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 565655000801 putative translocon binding site; other site 565655000802 protein-rRNA interface [nucleotide binding]; other site 565655000803 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 565655000804 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 565655000805 G-X-X-G motif; other site 565655000806 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 565655000807 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 565655000808 23S rRNA interface [nucleotide binding]; other site 565655000809 5S rRNA interface [nucleotide binding]; other site 565655000810 putative antibiotic binding site [chemical binding]; other site 565655000811 L25 interface [polypeptide binding]; other site 565655000812 L27 interface [polypeptide binding]; other site 565655000813 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 565655000814 23S rRNA interface [nucleotide binding]; other site 565655000815 putative translocon interaction site; other site 565655000816 signal recognition particle (SRP54) interaction site; other site 565655000817 L23 interface [polypeptide binding]; other site 565655000818 trigger factor interaction site; other site 565655000819 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 565655000820 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 565655000821 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 565655000822 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 565655000823 RNA binding site [nucleotide binding]; other site 565655000824 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 565655000825 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 565655000826 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 565655000827 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 565655000828 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 565655000829 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 565655000830 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 565655000831 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 565655000832 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 565655000833 5S rRNA interface [nucleotide binding]; other site 565655000834 L27 interface [polypeptide binding]; other site 565655000835 23S rRNA interface [nucleotide binding]; other site 565655000836 L5 interface [polypeptide binding]; other site 565655000837 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 565655000838 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 565655000839 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 565655000840 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 565655000841 23S rRNA binding site [nucleotide binding]; other site 565655000842 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 565655000843 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 565655000844 SecY translocase; Region: SecY; pfam00344 565655000845 adenylate kinase; Reviewed; Region: adk; PRK00279 565655000846 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 565655000847 AMP-binding site [chemical binding]; other site 565655000848 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 565655000849 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 565655000850 rRNA binding site [nucleotide binding]; other site 565655000851 predicted 30S ribosome binding site; other site 565655000852 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 565655000853 30S ribosomal protein S13; Region: bact_S13; TIGR03631 565655000854 30S ribosomal protein S11; Validated; Region: PRK05309 565655000855 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 565655000856 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 565655000857 alphaNTD homodimer interface [polypeptide binding]; other site 565655000858 alphaNTD - beta interaction site [polypeptide binding]; other site 565655000859 alphaNTD - beta' interaction site [polypeptide binding]; other site 565655000860 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 565655000861 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 565655000862 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635 565655000863 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 565655000864 Walker A/P-loop; other site 565655000865 ATP binding site [chemical binding]; other site 565655000866 Q-loop/lid; other site 565655000867 ABC transporter signature motif; other site 565655000868 Walker B; other site 565655000869 D-loop; other site 565655000870 H-loop/switch region; other site 565655000871 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13634 565655000872 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 565655000873 Walker A/P-loop; other site 565655000874 ATP binding site [chemical binding]; other site 565655000875 Q-loop/lid; other site 565655000876 ABC transporter signature motif; other site 565655000877 Walker B; other site 565655000878 D-loop; other site 565655000879 H-loop/switch region; other site 565655000880 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 565655000881 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 565655000882 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 565655000883 dimerization interface 3.5A [polypeptide binding]; other site 565655000884 active site 565655000885 H+ Antiporter protein; Region: 2A0121; TIGR00900 565655000886 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 565655000887 non-specific DNA binding site [nucleotide binding]; other site 565655000888 salt bridge; other site 565655000889 sequence-specific DNA binding site [nucleotide binding]; other site 565655000890 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 565655000891 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 565655000892 Predicted membrane protein [Function unknown]; Region: COG3463 565655000893 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 565655000894 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 565655000895 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 565655000896 DAK2 domain; Region: Dak2; pfam02734 565655000897 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 565655000898 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 565655000899 generic binding surface II; other site 565655000900 ssDNA binding site; other site 565655000901 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 565655000902 ATP binding site [chemical binding]; other site 565655000903 putative Mg++ binding site [ion binding]; other site 565655000904 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 565655000905 nucleotide binding region [chemical binding]; other site 565655000906 ATP-binding site [chemical binding]; other site 565655000907 putative phosphate acyltransferase; Provisional; Region: PRK05331 565655000908 acyl carrier protein; Provisional; Region: acpP; PRK00982 565655000909 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 565655000910 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 565655000911 Walker A/P-loop; other site 565655000912 ATP binding site [chemical binding]; other site 565655000913 Q-loop/lid; other site 565655000914 ABC transporter signature motif; other site 565655000915 Walker B; other site 565655000916 D-loop; other site 565655000917 H-loop/switch region; other site 565655000918 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 565655000919 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 565655000920 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 565655000921 Walker A/P-loop; other site 565655000922 ATP binding site [chemical binding]; other site 565655000923 Q-loop/lid; other site 565655000924 ABC transporter signature motif; other site 565655000925 Walker B; other site 565655000926 D-loop; other site 565655000927 H-loop/switch region; other site 565655000928 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 565655000929 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 565655000930 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 565655000931 dimer interface [polypeptide binding]; other site 565655000932 conserved gate region; other site 565655000933 putative PBP binding loops; other site 565655000934 ABC-ATPase subunit interface; other site 565655000935 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SapC; COG4171 565655000936 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 565655000937 dimer interface [polypeptide binding]; other site 565655000938 ABC-ATPase subunit interface; other site 565655000939 putative PBP binding loops; other site 565655000940 The substrate binding component of an ABC-type lactococcal OppA-like transport system contains; Region: PBP2_Lactococcal_OppA_like; cd08510 565655000941 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 565655000942 peptide binding site [polypeptide binding]; other site 565655000943 ribonuclease III; Reviewed; Region: rnc; PRK00102 565655000944 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 565655000945 dimerization interface [polypeptide binding]; other site 565655000946 active site 565655000947 metal binding site [ion binding]; metal-binding site 565655000948 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 565655000949 dsRNA binding site [nucleotide binding]; other site 565655000950 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 565655000951 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 565655000952 Walker A/P-loop; other site 565655000953 ATP binding site [chemical binding]; other site 565655000954 Q-loop/lid; other site 565655000955 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 565655000956 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 565655000957 ABC transporter signature motif; other site 565655000958 Walker B; other site 565655000959 D-loop; other site 565655000960 H-loop/switch region; other site 565655000961 sugar phosphate phosphatase; Provisional; Region: PRK10513 565655000962 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 565655000963 active site 565655000964 motif I; other site 565655000965 motif II; other site 565655000966 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 565655000967 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 565655000968 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 565655000969 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 565655000970 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 565655000971 P loop; other site 565655000972 GTP binding site [chemical binding]; other site 565655000973 Penicillinase repressor; Region: Pencillinase_R; cl17580 565655000974 bifunctional glutamate--cysteine ligase/glutathione synthetase; Provisional; Region: PRK02471 565655000975 Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352 565655000976 ATP-grasp domain; Region: ATP-grasp_4; cl17255 565655000977 Protein of unknown function (DUF1694); Region: DUF1694; pfam07997 565655000978 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 565655000979 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 565655000980 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 565655000981 putative phosphoesterase; Region: acc_ester; TIGR03729 565655000982 Protein of unknown function (DUF2829); Region: DUF2829; pfam11195 565655000983 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK06550 565655000984 classical (c) SDRs; Region: SDR_c; cd05233 565655000985 NAD(P) binding site [chemical binding]; other site 565655000986 active site 565655000987 Bacterial protein of unknown function (DUF925); Region: DUF925; pfam06042 565655000988 BioY family; Region: BioY; pfam02632 565655000989 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 565655000990 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 565655000991 non-specific DNA binding site [nucleotide binding]; other site 565655000992 salt bridge; other site 565655000993 sequence-specific DNA binding site [nucleotide binding]; other site 565655000994 isocitrate dehydrogenase; Validated; Region: PRK06451 565655000995 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 565655000996 aconitate hydratase; Validated; Region: PRK09277 565655000997 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 565655000998 substrate binding site [chemical binding]; other site 565655000999 ligand binding site [chemical binding]; other site 565655001000 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 565655001001 substrate binding site [chemical binding]; other site 565655001002 Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_1_2; cd06113 565655001003 dimer interface [polypeptide binding]; other site 565655001004 Citrate synthase; Region: Citrate_synt; pfam00285 565655001005 active site 565655001006 citrylCoA binding site [chemical binding]; other site 565655001007 oxalacetate/citrate binding site [chemical binding]; other site 565655001008 coenzyme A binding site [chemical binding]; other site 565655001009 catalytic triad [active] 565655001010 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 565655001011 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 565655001012 Peptidase family M23; Region: Peptidase_M23; pfam01551 565655001013 Asp23 family; Region: Asp23; pfam03780 565655001014 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 565655001015 ArsC family; Region: ArsC; pfam03960 565655001016 putative catalytic residues [active] 565655001017 thiol/disulfide switch; other site 565655001018 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 565655001019 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 565655001020 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 565655001021 RNA binding surface [nucleotide binding]; other site 565655001022 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927 565655001023 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 565655001024 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 565655001025 active site 565655001026 motif I; other site 565655001027 motif II; other site 565655001028 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 565655001029 active site 565655001030 dimer interfaces [polypeptide binding]; other site 565655001031 catalytic residues [active] 565655001032 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 565655001033 peptidase T; Region: peptidase-T; TIGR01882 565655001034 metal binding site [ion binding]; metal-binding site 565655001035 dimer interface [polypeptide binding]; other site 565655001036 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 565655001037 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 565655001038 putative active site [active] 565655001039 metal binding site [ion binding]; metal-binding site 565655001040 homodimer binding site [polypeptide binding]; other site 565655001041 Protein of unknown function (DUF964); Region: DUF964; cl01483 565655001042 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 565655001043 MutS domain I; Region: MutS_I; pfam01624 565655001044 MutS domain II; Region: MutS_II; pfam05188 565655001045 MutS domain III; Region: MutS_III; pfam05192 565655001046 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 565655001047 Walker A/P-loop; other site 565655001048 ATP binding site [chemical binding]; other site 565655001049 Q-loop/lid; other site 565655001050 ABC transporter signature motif; other site 565655001051 Walker B; other site 565655001052 D-loop; other site 565655001053 H-loop/switch region; other site 565655001054 DNA mismatch repair enzyme (predicted ATPase) [DNA replication, recombination, and repair]; Region: MutL; COG0323 565655001055 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 565655001056 ATP binding site [chemical binding]; other site 565655001057 Mg2+ binding site [ion binding]; other site 565655001058 G-X-G motif; other site 565655001059 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 565655001060 ATP binding site [chemical binding]; other site 565655001061 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 565655001062 Maf-like protein; Region: Maf; pfam02545 565655001063 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 565655001064 active site 565655001065 dimer interface [polypeptide binding]; other site 565655001066 Uncharacterized conserved protein [Function unknown]; Region: COG3791 565655001067 methionine sulfoxide reductase B; Provisional; Region: PRK00222 565655001068 SelR domain; Region: SelR; pfam01641 565655001069 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 565655001070 RuvA N terminal domain; Region: RuvA_N; pfam01330 565655001071 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 565655001072 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 565655001073 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 565655001074 Walker A motif; other site 565655001075 ATP binding site [chemical binding]; other site 565655001076 Walker B motif; other site 565655001077 arginine finger; other site 565655001078 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 565655001079 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 565655001080 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 565655001081 dimer interface [polypeptide binding]; other site 565655001082 conserved gate region; other site 565655001083 ABC-ATPase subunit interface; other site 565655001084 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 565655001085 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 565655001086 dimer interface [polypeptide binding]; other site 565655001087 conserved gate region; other site 565655001088 ABC-ATPase subunit interface; other site 565655001089 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 565655001090 Protein of unknown function, DUF624; Region: DUF624; cl02369 565655001091 Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448 565655001092 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 565655001093 Exonuclease-Endonuclease-Phosphatase domain; uncharacterized family 1; Region: EEP-1; cd09083 565655001094 putative catalytic site [active] 565655001095 putative metal binding site [ion binding]; other site 565655001096 putative phosphate binding site [ion binding]; other site 565655001097 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 565655001098 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 565655001099 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 565655001100 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 565655001101 Transcriptional regulators [Transcription]; Region: PurR; COG1609 565655001102 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 565655001103 DNA binding site [nucleotide binding] 565655001104 domain linker motif; other site 565655001105 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 565655001106 dimerization interface [polypeptide binding]; other site 565655001107 ligand binding site [chemical binding]; other site 565655001108 WxL domain surface cell wall-binding; Region: WxL; pfam13731 565655001109 WxL domain surface cell wall-binding; Region: WxL; pfam13731 565655001110 WxL domain surface cell wall-binding; Region: WxL; pfam13731 565655001111 WxL domain surface cell wall-binding; Region: WxL; pfam13731 565655001112 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 565655001113 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 565655001114 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098 565655001115 active site 565655001116 catalytic site [active] 565655001117 Mga helix-turn-helix domain; Region: Mga; pfam05043 565655001118 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 565655001119 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 565655001120 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 565655001121 Low molecular weight phosphatase family; Region: LMWPc; cd00115 565655001122 active site 565655001123 Domain of unknown function (DU1801); Region: DUF1801; cl17490 565655001124 Mga helix-turn-helix domain; Region: Mga; pfam05043 565655001125 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 565655001126 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 565655001127 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 565655001128 Walker A/P-loop; other site 565655001129 ATP binding site [chemical binding]; other site 565655001130 Q-loop/lid; other site 565655001131 ABC transporter signature motif; other site 565655001132 Walker B; other site 565655001133 D-loop; other site 565655001134 H-loop/switch region; other site 565655001135 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 565655001136 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 565655001137 substrate binding pocket [chemical binding]; other site 565655001138 membrane-bound complex binding site; other site 565655001139 hinge residues; other site 565655001140 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 565655001141 dimer interface [polypeptide binding]; other site 565655001142 conserved gate region; other site 565655001143 putative PBP binding loops; other site 565655001144 ABC-ATPase subunit interface; other site 565655001145 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 565655001146 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 565655001147 Walker A/P-loop; other site 565655001148 ATP binding site [chemical binding]; other site 565655001149 Q-loop/lid; other site 565655001150 ABC transporter signature motif; other site 565655001151 Walker B; other site 565655001152 D-loop; other site 565655001153 H-loop/switch region; other site 565655001154 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 565655001155 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 565655001156 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 565655001157 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 565655001158 dimer interface [polypeptide binding]; other site 565655001159 phosphorylation site [posttranslational modification] 565655001160 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 565655001161 ATP binding site [chemical binding]; other site 565655001162 Mg2+ binding site [ion binding]; other site 565655001163 G-X-G motif; other site 565655001164 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 565655001165 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 565655001166 active site 565655001167 phosphorylation site [posttranslational modification] 565655001168 intermolecular recognition site; other site 565655001169 dimerization interface [polypeptide binding]; other site 565655001170 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 565655001171 DNA binding site [nucleotide binding] 565655001172 NAD-dependent deacetylase; Provisional; Region: PRK00481 565655001173 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 565655001174 maltose O-acetyltransferase; Provisional; Region: PRK10092 565655001175 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 565655001176 active site 565655001177 substrate binding site [chemical binding]; other site 565655001178 trimer interface [polypeptide binding]; other site 565655001179 CoA binding site [chemical binding]; other site 565655001180 hypothetical protein; Provisional; Region: PRK07248 565655001181 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 565655001182 HTH domain; Region: HTH_11; pfam08279 565655001183 3H domain; Region: 3H; pfam02829 565655001184 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 565655001185 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 565655001186 Walker A/P-loop; other site 565655001187 ATP binding site [chemical binding]; other site 565655001188 Q-loop/lid; other site 565655001189 ABC transporter signature motif; other site 565655001190 Walker B; other site 565655001191 D-loop; other site 565655001192 H-loop/switch region; other site 565655001193 NIL domain; Region: NIL; pfam09383 565655001194 ABC-type metal ion transport system, permease component [Inorganic ion transport and metabolism]; Region: AbcD; COG2011 565655001195 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 565655001196 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 565655001197 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 565655001198 amidohydrolase; Region: amidohydrolases; TIGR01891 565655001199 metal binding site [ion binding]; metal-binding site 565655001200 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 565655001201 active site 565655001202 catalytic residues [active] 565655001203 metal binding site [ion binding]; metal-binding site 565655001204 Uncharacterized conserved protein [Function unknown]; Region: COG3589 565655001205 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 565655001206 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 565655001207 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 565655001208 putative active site [active] 565655001209 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 565655001210 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 565655001211 active site turn [active] 565655001212 phosphorylation site [posttranslational modification] 565655001213 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 565655001214 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 565655001215 HPr interaction site; other site 565655001216 glycerol kinase (GK) interaction site [polypeptide binding]; other site 565655001217 active site 565655001218 phosphorylation site [posttranslational modification] 565655001219 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 565655001220 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 565655001221 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 565655001222 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 565655001223 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 565655001224 Walker A/P-loop; other site 565655001225 ATP binding site [chemical binding]; other site 565655001226 Q-loop/lid; other site 565655001227 ABC transporter signature motif; other site 565655001228 Walker B; other site 565655001229 D-loop; other site 565655001230 H-loop/switch region; other site 565655001231 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 565655001232 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 565655001233 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 565655001234 Walker A/P-loop; other site 565655001235 ATP binding site [chemical binding]; other site 565655001236 Q-loop/lid; other site 565655001237 ABC transporter signature motif; other site 565655001238 Walker B; other site 565655001239 D-loop; other site 565655001240 H-loop/switch region; other site 565655001241 acetylornithine aminotransferase; Provisional; Region: argD; PRK02936 565655001242 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 565655001243 inhibitor-cofactor binding pocket; inhibition site 565655001244 pyridoxal 5'-phosphate binding site [chemical binding]; other site 565655001245 catalytic residue [active] 565655001246 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 565655001247 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 565655001248 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 565655001249 heterotetramer interface [polypeptide binding]; other site 565655001250 active site pocket [active] 565655001251 cleavage site 565655001252 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 565655001253 nucleotide binding site [chemical binding]; other site 565655001254 N-acetyl-L-glutamate binding site [chemical binding]; other site 565655001255 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 565655001256 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 565655001257 active site 565655001258 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 565655001259 Beta-lactamase; Region: Beta-lactamase; pfam00144 565655001260 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 565655001261 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 565655001262 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 565655001263 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 565655001264 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 565655001265 catalytic residue [active] 565655001266 Putative amino acid metabolism; Region: DUF1831; pfam08866 565655001267 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 565655001268 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 565655001269 active site 565655001270 catalytic tetrad [active] 565655001271 Aquifex aeolicus AQ1575 and related proteins, metallophosphatase domain; Region: MPP_AQ1575; cd07390 565655001272 putative active site [active] 565655001273 putative metal binding site [ion binding]; other site 565655001274 Small integral membrane protein (DUF2273); Region: DUF2273; pfam10031 565655001275 Asp23 family; Region: Asp23; pfam03780 565655001276 Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529 565655001277 putative active site [active] 565655001278 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 565655001279 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 565655001280 Ligand Binding Site [chemical binding]; other site 565655001281 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 565655001282 AAA domain; Region: AAA_21; pfam13304 565655001283 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 565655001284 Walker B; other site 565655001285 D-loop; other site 565655001286 H-loop/switch region; other site 565655001287 DNA topoisomerase III; Provisional; Region: PRK07726 565655001288 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 565655001289 active site 565655001290 putative interdomain interaction site [polypeptide binding]; other site 565655001291 putative metal-binding site [ion binding]; other site 565655001292 putative nucleotide binding site [chemical binding]; other site 565655001293 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 565655001294 domain I; other site 565655001295 DNA binding groove [nucleotide binding] 565655001296 phosphate binding site [ion binding]; other site 565655001297 domain II; other site 565655001298 domain III; other site 565655001299 nucleotide binding site [chemical binding]; other site 565655001300 catalytic site [active] 565655001301 domain IV; other site 565655001302 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 565655001303 Response regulator receiver domain; Region: Response_reg; pfam00072 565655001304 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 565655001305 active site 565655001306 phosphorylation site [posttranslational modification] 565655001307 intermolecular recognition site; other site 565655001308 dimerization interface [polypeptide binding]; other site 565655001309 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 565655001310 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 565655001311 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 565655001312 dimerization interface [polypeptide binding]; other site 565655001313 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 565655001314 Histidine kinase; Region: His_kinase; pfam06580 565655001315 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 565655001316 ATP binding site [chemical binding]; other site 565655001317 Mg2+ binding site [ion binding]; other site 565655001318 G-X-G motif; other site 565655001319 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 565655001320 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 565655001321 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 565655001322 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 565655001323 putative ligand binding site [chemical binding]; other site 565655001324 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 565655001325 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 565655001326 Walker A/P-loop; other site 565655001327 ATP binding site [chemical binding]; other site 565655001328 Q-loop/lid; other site 565655001329 ABC transporter signature motif; other site 565655001330 Walker B; other site 565655001331 D-loop; other site 565655001332 H-loop/switch region; other site 565655001333 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 565655001334 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 565655001335 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 565655001336 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 565655001337 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 565655001338 TM-ABC transporter signature motif; other site 565655001339 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 565655001340 active site 565655001341 P-loop; other site 565655001342 phosphorylation site [posttranslational modification] 565655001343 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 565655001344 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 565655001345 Walker A/P-loop; other site 565655001346 ATP binding site [chemical binding]; other site 565655001347 Q-loop/lid; other site 565655001348 ABC transporter signature motif; other site 565655001349 Walker B; other site 565655001350 D-loop; other site 565655001351 H-loop/switch region; other site 565655001352 TOBE domain; Region: TOBE_2; pfam08402 565655001353 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 565655001354 Short C-terminal domain; Region: SHOCT; pfam09851 565655001355 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 565655001356 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 565655001357 DNA-binding site [nucleotide binding]; DNA binding site 565655001358 Transcriptional regulators [Transcription]; Region: PurR; COG1609 565655001359 Ligand-binding domain of DNA transcription repressor specific for arabinose (AraR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AraR; cd01541 565655001360 putative dimerization interface [polypeptide binding]; other site 565655001361 putative ligand binding site [chemical binding]; other site 565655001362 L-ribulokinase-like proteins; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-RBK_like; cd07778 565655001363 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 565655001364 putative N- and C-terminal domain interface [polypeptide binding]; other site 565655001365 putative active site [active] 565655001366 MgATP binding site [chemical binding]; other site 565655001367 catalytic site [active] 565655001368 metal binding site [ion binding]; metal-binding site 565655001369 putative carbohydrate binding site [chemical binding]; other site 565655001370 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 565655001371 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 565655001372 intersubunit interface [polypeptide binding]; other site 565655001373 active site 565655001374 Zn2+ binding site [ion binding]; other site 565655001375 L-arabinose isomerase; Provisional; Region: PRK02929 565655001376 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 565655001377 hexamer (dimer of trimers) interface [polypeptide binding]; other site 565655001378 trimer interface [polypeptide binding]; other site 565655001379 substrate binding site [chemical binding]; other site 565655001380 Mn binding site [ion binding]; other site 565655001381 XFP N-terminal domain; Region: XFP_N; pfam09364 565655001382 putative phosphoketolase; Provisional; Region: PRK05261 565655001383 XFP C-terminal domain; Region: XFP_C; pfam09363 565655001384 Transcriptional regulator [Transcription]; Region: LysR; COG0583 565655001385 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 565655001386 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 565655001387 dimerization interface [polypeptide binding]; other site 565655001388 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 565655001389 substrate binding site [chemical binding]; other site 565655001390 THF binding site; other site 565655001391 zinc-binding site [ion binding]; other site 565655001392 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 565655001393 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 565655001394 dimer interface [polypeptide binding]; other site 565655001395 conserved gate region; other site 565655001396 putative PBP binding loops; other site 565655001397 ABC-ATPase subunit interface; other site 565655001398 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 565655001399 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 565655001400 Walker A/P-loop; other site 565655001401 ATP binding site [chemical binding]; other site 565655001402 Q-loop/lid; other site 565655001403 ABC transporter signature motif; other site 565655001404 Walker B; other site 565655001405 D-loop; other site 565655001406 H-loop/switch region; other site 565655001407 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 565655001408 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 565655001409 substrate binding pocket [chemical binding]; other site 565655001410 membrane-bound complex binding site; other site 565655001411 hinge residues; other site 565655001412 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 565655001413 PIN domain; Region: PIN_3; pfam13470 565655001414 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 565655001415 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 565655001416 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 565655001417 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 565655001418 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 565655001419 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 565655001420 DNA-binding site [nucleotide binding]; DNA binding site 565655001421 UTRA domain; Region: UTRA; pfam07702 565655001422 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 565655001423 pyrroline-5-carboxylate reductase; Region: PLN02688 565655001424 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 565655001425 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 565655001426 motif II; other site 565655001427 Predicted membrane protein [Function unknown]; Region: COG1511 565655001428 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 565655001429 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 565655001430 Amino acid permease; Region: AA_permease_2; pfam13520 565655001431 Predicted transcriptional regulator [Transcription]; Region: COG4189 565655001432 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 565655001433 putative DNA binding site [nucleotide binding]; other site 565655001434 dimerization interface [polypeptide binding]; other site 565655001435 putative Zn2+ binding site [ion binding]; other site 565655001436 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 565655001437 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 565655001438 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 565655001439 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 565655001440 dimer interface [polypeptide binding]; other site 565655001441 conserved gate region; other site 565655001442 putative PBP binding loops; other site 565655001443 ABC-ATPase subunit interface; other site 565655001444 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 565655001445 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 565655001446 dimer interface [polypeptide binding]; other site 565655001447 conserved gate region; other site 565655001448 putative PBP binding loops; other site 565655001449 ABC-ATPase subunit interface; other site 565655001450 Glycosyl hydrolase family 43; Region: GH43_ABN_1; cd08998 565655001451 substrate binding site [chemical binding]; other site 565655001452 active site 565655001453 Glycosyl hydrolase family 43; Region: GH43_1; cd08980 565655001454 active site 565655001455 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 565655001456 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 565655001457 Glycosyl hydrolase family 43; Region: GH43_ABN_1; cd08998 565655001458 substrate binding site [chemical binding]; other site 565655001459 active site 565655001460 alpha-galactosidase; Region: PLN02808; cl17638 565655001461 Cupin domain; Region: Cupin_2; pfam07883 565655001462 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 565655001463 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 565655001464 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 565655001465 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 565655001466 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 565655001467 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 565655001468 Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389 565655001469 Endo-beta-N-acetylglucosaminidase D [Carbohydrate transport and metabolism]; Region: COG4724 565655001470 Endo-beta-N-acetylglucosaminidase (ENGase) hydrolyzes the N-N'-diacetylchitobiosyl core of N-glycosylproteins. The beta-1,4-glycosyl bond located between two N-acetylglucosamine residues is hydrolyzed such that N-acetylglucosamine 1 remains with...; Region: GH85_ENGase; cd06547 565655001471 putative active site [active] 565655001472 FOG: PKD repeat [General function prediction only]; Region: COG3291 565655001473 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 565655001474 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 565655001475 sugar binding site [chemical binding]; other site 565655001476 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 565655001477 dimer interface [polypeptide binding]; other site 565655001478 conserved gate region; other site 565655001479 putative PBP binding loops; other site 565655001480 ABC-ATPase subunit interface; other site 565655001481 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 565655001482 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 565655001483 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 565655001484 dimer interface [polypeptide binding]; other site 565655001485 conserved gate region; other site 565655001486 putative PBP binding loops; other site 565655001487 ABC-ATPase subunit interface; other site 565655001488 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 565655001489 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 565655001490 Walker A/P-loop; other site 565655001491 ATP binding site [chemical binding]; other site 565655001492 Q-loop/lid; other site 565655001493 ABC transporter signature motif; other site 565655001494 Walker B; other site 565655001495 D-loop; other site 565655001496 H-loop/switch region; other site 565655001497 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 565655001498 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 565655001499 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 565655001500 Protein of unknown function (DUF975); Region: DUF975; cl10504 565655001501 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 565655001502 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 565655001503 Preprotein translocase subunit; Region: YajC; cl00806 565655001504 Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471 565655001505 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 565655001506 putative dimer interface [polypeptide binding]; other site 565655001507 Uncharacterized conserved protein [Function unknown]; Region: COG1284 565655001508 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 565655001509 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 565655001510 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 565655001511 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 565655001512 DNA-binding site [nucleotide binding]; DNA binding site 565655001513 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 565655001514 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 565655001515 dipeptidase, putative; Region: dipeptidaselike; TIGR01887 565655001516 active site 565655001517 metal binding site [ion binding]; metal-binding site 565655001518 Glycosylasparaginase catalyzes the hydrolysis of the glycosylamide bond of asparagine-linked glycoproteins. This enzyme is an amidase located inside lysosomes. Mutation of this gene in humans causes a genetic disorder known as aspartylglycosaminuria (AGU)...; Region: Glycosylasparaginase; cd04513 565655001519 active site 565655001520 dimer interface [polypeptide binding]; other site 565655001521 catalytic nucleophile [active] 565655001522 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 565655001523 active site 565655001524 P-loop; other site 565655001525 phosphorylation site [posttranslational modification] 565655001526 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 565655001527 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 565655001528 glycine reductase, selenoprotein B; Region: gly_red_sel_B; TIGR01917 565655001529 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 565655001530 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 565655001531 putative catalytic cysteine [active] 565655001532 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 565655001533 putative active site [active] 565655001534 metal binding site [ion binding]; metal-binding site 565655001535 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 565655001536 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 565655001537 Helix-turn-helix domain; Region: HTH_18; pfam12833 565655001538 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 565655001539 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 565655001540 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 565655001541 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 565655001542 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 565655001543 Walker A/P-loop; other site 565655001544 ATP binding site [chemical binding]; other site 565655001545 Q-loop/lid; other site 565655001546 ABC transporter signature motif; other site 565655001547 Walker B; other site 565655001548 D-loop; other site 565655001549 H-loop/switch region; other site 565655001550 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 565655001551 FeS assembly protein SufD; Region: sufD; TIGR01981 565655001552 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 565655001553 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 565655001554 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 565655001555 catalytic residue [active] 565655001556 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 565655001557 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 565655001558 trimerization site [polypeptide binding]; other site 565655001559 active site 565655001560 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 565655001561 FeS assembly protein SufB; Region: sufB; TIGR01980 565655001562 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 565655001563 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 565655001564 Int/Topo IB signature motif; other site 565655001565 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 565655001566 non-specific DNA binding site [nucleotide binding]; other site 565655001567 salt bridge; other site 565655001568 sequence-specific DNA binding site [nucleotide binding]; other site 565655001569 Helix-turn-helix domain; Region: HTH_17; pfam12728 565655001570 TrbC/VIRB2 family; Region: TrbC; pfam04956 565655001571 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 565655001572 NACHT domain; Region: NACHT; pfam05729 565655001573 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4913 565655001574 P-loop containing region of AAA domain; Region: AAA_29; pfam13555 565655001575 Tubulin binding cofactor A; Region: TBCA; pfam02970 565655001576 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; cl05797 565655001577 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 565655001578 Uncharacterized protein conserved in bacteria C-term(DUF2220); Region: DUF2220; pfam09983 565655001579 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 565655001580 dimer interface [polypeptide binding]; other site 565655001581 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 565655001582 AAA domain; Region: AAA_13; pfam13166 565655001583 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 565655001584 non-specific DNA binding site [nucleotide binding]; other site 565655001585 salt bridge; other site 565655001586 sequence-specific DNA binding site [nucleotide binding]; other site 565655001587 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 565655001588 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 565655001589 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 565655001590 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 565655001591 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 565655001592 dimer interface [polypeptide binding]; other site 565655001593 conserved gate region; other site 565655001594 putative PBP binding loops; other site 565655001595 ABC-ATPase subunit interface; other site 565655001596 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 565655001597 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 565655001598 dimer interface [polypeptide binding]; other site 565655001599 conserved gate region; other site 565655001600 putative PBP binding loops; other site 565655001601 ABC-ATPase subunit interface; other site 565655001602 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 565655001603 Melibiase; Region: Melibiase; pfam02065 565655001604 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 565655001605 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 565655001606 DNA-binding site [nucleotide binding]; DNA binding site 565655001607 UTRA domain; Region: UTRA; pfam07702 565655001608 Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448 565655001609 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 565655001610 beta-galactosidase; Region: BGL; TIGR03356 565655001611 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 565655001612 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 565655001613 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 565655001614 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 565655001615 active site turn [active] 565655001616 phosphorylation site [posttranslational modification] 565655001617 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 565655001618 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 565655001619 HPr interaction site; other site 565655001620 glycerol kinase (GK) interaction site [polypeptide binding]; other site 565655001621 active site 565655001622 phosphorylation site [posttranslational modification] 565655001623 Uncharacterized conserved protein [Function unknown]; Region: COG5476 565655001624 Protein of unknown function (DUF1485); Region: DUF1485; pfam07364 565655001625 MlrC C-terminus; Region: MlrC_C; pfam07171 565655001626 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 565655001627 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 565655001628 active site 565655001629 CAT RNA binding domain; Region: CAT_RBD; cl03904 565655001630 PRD domain; Region: PRD; pfam00874 565655001631 PRD domain; Region: PRD; pfam00874 565655001632 Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803 565655001633 putative active site [active] 565655001634 YdjC motif; other site 565655001635 Mg binding site [ion binding]; other site 565655001636 putative homodimer interface [polypeptide binding]; other site 565655001637 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 565655001638 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 565655001639 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 565655001640 active site turn [active] 565655001641 phosphorylation site [posttranslational modification] 565655001642 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 565655001643 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 565655001644 NAD(P) binding site [chemical binding]; other site 565655001645 LDH/MDH dimer interface [polypeptide binding]; other site 565655001646 substrate binding site [chemical binding]; other site 565655001647 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 565655001648 HPr interaction site; other site 565655001649 glycerol kinase (GK) interaction site [polypeptide binding]; other site 565655001650 active site 565655001651 phosphorylation site [posttranslational modification] 565655001652 Sugar transport protein; Region: Sugar_transport; pfam06800 565655001653 GIY-YIG domain of uncharacterized bacterial protein structurally related to COG3410; Region: GIY-YIG_COG3410; cd10439 565655001654 GIY-YIG motif/motif A; other site 565655001655 putative active site [active] 565655001656 putative metal binding site [ion binding]; other site 565655001657 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 565655001658 Uncharacterized conserved protein (DUF2075); Region: DUF2075; pfam09848 565655001659 Walker A motif; other site 565655001660 ATP binding site [chemical binding]; other site 565655001661 Walker B motif; other site 565655001662 Uncharacterized conserved protein [Function unknown]; Region: COG3410 565655001663 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537 565655001664 homodimer interface [polypeptide binding]; other site 565655001665 chemical substrate binding site [chemical binding]; other site 565655001666 oligomer interface [polypeptide binding]; other site 565655001667 metal binding site [ion binding]; metal-binding site 565655001668 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 565655001669 putative active site [active] 565655001670 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 565655001671 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 565655001672 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 565655001673 active site turn [active] 565655001674 phosphorylation site [posttranslational modification] 565655001675 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 565655001676 Beta-lactamase; Region: Beta-lactamase; pfam00144 565655001677 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 565655001678 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 565655001679 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 565655001680 Walker A/P-loop; other site 565655001681 ATP binding site [chemical binding]; other site 565655001682 Q-loop/lid; other site 565655001683 AAA domain; Region: AAA_21; pfam13304 565655001684 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 565655001685 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 565655001686 Walker A/P-loop; other site 565655001687 ATP binding site [chemical binding]; other site 565655001688 Q-loop/lid; other site 565655001689 ABC transporter signature motif; other site 565655001690 Walker B; other site 565655001691 D-loop; other site 565655001692 H-loop/switch region; other site 565655001693 Mga helix-turn-helix domain; Region: Mga; pfam05043 565655001694 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 565655001695 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 565655001696 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 565655001697 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 565655001698 metal binding site [ion binding]; metal-binding site 565655001699 active site 565655001700 I-site; other site 565655001701 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 565655001702 Protein of unknown function (DUF2000); Region: DUF2000; pfam09391 565655001703 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 565655001704 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 565655001705 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 565655001706 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 565655001707 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 565655001708 beta-galactosidase; Region: BGL; TIGR03356 565655001709 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 565655001710 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 565655001711 DNA-binding site [nucleotide binding]; DNA binding site 565655001712 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 565655001713 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 565655001714 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 565655001715 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 565655001716 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 565655001717 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 565655001718 putative active site [active] 565655001719 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 565655001720 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 565655001721 NAD binding site [chemical binding]; other site 565655001722 sugar binding site [chemical binding]; other site 565655001723 divalent metal binding site [ion binding]; other site 565655001724 tetramer (dimer of dimers) interface [polypeptide binding]; other site 565655001725 dimer interface [polypeptide binding]; other site 565655001726 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 565655001727 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 565655001728 active site 565655001729 trimer interface [polypeptide binding]; other site 565655001730 allosteric site; other site 565655001731 active site lid [active] 565655001732 hexamer (dimer of trimers) interface [polypeptide binding]; other site 565655001733 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 565655001734 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 565655001735 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 565655001736 Mga helix-turn-helix domain; Region: Mga; pfam05043 565655001737 PRD domain; Region: PRD; pfam00874 565655001738 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 565655001739 active site 565655001740 P-loop; other site 565655001741 phosphorylation site [posttranslational modification] 565655001742 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 565655001743 active site 565655001744 phosphorylation site [posttranslational modification] 565655001745 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 565655001746 active site 565655001747 P-loop; other site 565655001748 phosphorylation site [posttranslational modification] 565655001749 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 565655001750 transketolase; Reviewed; Region: PRK05899 565655001751 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 565655001752 TPP-binding site [chemical binding]; other site 565655001753 dimer interface [polypeptide binding]; other site 565655001754 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 565655001755 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 565655001756 PYR/PP interface [polypeptide binding]; other site 565655001757 dimer interface [polypeptide binding]; other site 565655001758 TPP binding site [chemical binding]; other site 565655001759 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 565655001760 Bacterial PH domain; Region: DUF304; pfam03703 565655001761 Bacterial PH domain; Region: DUF304; pfam03703 565655001762 Bacterial PH domain; Region: DUF304; cl01348 565655001763 Uncharacterized conserved protein [Function unknown]; Region: COG3402 565655001764 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 565655001765 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 565655001766 S-adenosylmethionine binding site [chemical binding]; other site 565655001767 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 565655001768 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 565655001769 Coenzyme A binding pocket [chemical binding]; other site 565655001770 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK12815 565655001771 Predicted transcriptional regulator [Transcription]; Region: COG2378 565655001772 HTH domain; Region: HTH_11; pfam08279 565655001773 WYL domain; Region: WYL; pfam13280 565655001774 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 565655001775 Protein of unknown function (DUF1706); Region: DUF1706; pfam08020 565655001776 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 565655001777 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 565655001778 S-adenosylmethionine binding site [chemical binding]; other site 565655001779 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 565655001780 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 565655001781 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 565655001782 motif II; other site 565655001783 Transcriptional regulators [Transcription]; Region: PurR; COG1609 565655001784 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 565655001785 DNA binding site [nucleotide binding] 565655001786 domain linker motif; other site 565655001787 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 565655001788 Predicted phosphoadenosine phosphosulfate sulfotransferase [General function prediction only]; Region: COG3969 565655001789 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 565655001790 Active Sites [active] 565655001791 Domain of unknown function (DUF3440); Region: DUF3440; pfam11922 565655001792 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 565655001793 ParB-like nuclease domain; Region: ParBc; pfam02195 565655001794 Transcriptional regulator [Transcription]; Region: LysR; COG0583 565655001795 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 565655001796 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 565655001797 dimerization interface [polypeptide binding]; other site 565655001798 Mga helix-turn-helix domain; Region: Mga; pfam05043 565655001799 multiple promoter invertase; Provisional; Region: mpi; PRK13413 565655001800 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 565655001801 catalytic residues [active] 565655001802 catalytic nucleophile [active] 565655001803 Presynaptic Site I dimer interface [polypeptide binding]; other site 565655001804 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 565655001805 Synaptic Flat tetramer interface [polypeptide binding]; other site 565655001806 Synaptic Site I dimer interface [polypeptide binding]; other site 565655001807 DNA binding site [nucleotide binding] 565655001808 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 565655001809 DNA-binding interface [nucleotide binding]; DNA binding site 565655001810 Mga helix-turn-helix domain; Region: Mga; pfam05043 565655001811 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 565655001812 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 565655001813 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 565655001814 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 565655001815 Chain length determinant protein; Region: Wzz; cl15801 565655001816 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 565655001817 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 565655001818 Bacterial sugar transferase; Region: Bac_transf; pfam02397 565655001819 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 565655001820 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 565655001821 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 565655001822 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 565655001823 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 565655001824 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 565655001825 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 565655001826 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 565655001827 active site 565655001828 homodimer interface [polypeptide binding]; other site 565655001829 Mga helix-turn-helix domain; Region: Mga; pfam05043 565655001830 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 565655001831 Mga helix-turn-helix domain; Region: Mga; pfam05043 565655001832 WxL domain surface cell wall-binding; Region: WxL; pfam13731 565655001833 WxL domain surface cell wall-binding; Region: WxL; pfam13731 565655001834 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 565655001835 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 565655001836 HTH domain; Region: HTH_11; pfam08279 565655001837 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462 565655001838 Catalytic site [active] 565655001839 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 565655001840 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 565655001841 DNA binding residues [nucleotide binding] 565655001842 putative dimer interface [polypeptide binding]; other site 565655001843 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 565655001844 NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236 565655001845 putative NAD(P) binding site [chemical binding]; other site 565655001846 catalytic Zn binding site [ion binding]; other site 565655001847 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 565655001848 Malic enzyme, N-terminal domain; Region: malic; pfam00390 565655001849 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 565655001850 putative NAD(P) binding site [chemical binding]; other site 565655001851 2-hydroxycarboxylate transporter family; Region: 2HCT; pfam03390 565655001852 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 565655001853 CHASE4 domain; Region: CHASE4; cl01308 565655001854 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 565655001855 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 565655001856 active site 565655001857 phosphorylation site [posttranslational modification] 565655001858 intermolecular recognition site; other site 565655001859 dimerization interface [polypeptide binding]; other site 565655001860 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 565655001861 HTH domain; Region: HTH_11; cl17392 565655001862 Mga helix-turn-helix domain; Region: Mga; pfam05043 565655001863 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 565655001864 metal ion-dependent adhesion site (MIDAS); other site 565655001865 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 565655001866 domain interaction interfaces [polypeptide binding]; other site 565655001867 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 565655001868 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 565655001869 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 565655001870 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 565655001871 Walker A/P-loop; other site 565655001872 ATP binding site [chemical binding]; other site 565655001873 Q-loop/lid; other site 565655001874 ABC transporter signature motif; other site 565655001875 Walker B; other site 565655001876 D-loop; other site 565655001877 H-loop/switch region; other site 565655001878 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 565655001879 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 565655001880 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 565655001881 Walker A/P-loop; other site 565655001882 ATP binding site [chemical binding]; other site 565655001883 Q-loop/lid; other site 565655001884 ABC transporter signature motif; other site 565655001885 Walker B; other site 565655001886 D-loop; other site 565655001887 H-loop/switch region; other site 565655001888 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 565655001889 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 565655001890 DNA binding residues [nucleotide binding] 565655001891 drug binding residues [chemical binding]; other site 565655001892 dimer interface [polypeptide binding]; other site 565655001893 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 565655001894 Predicted membrane protein [Function unknown]; Region: COG2364 565655001895 tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144 565655001896 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 565655001897 S-adenosylmethionine binding site [chemical binding]; other site 565655001898 Uncharacterized conserved protein [Function unknown]; Region: COG3270 565655001899 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 565655001900 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 565655001901 nucleoside/Zn binding site; other site 565655001902 dimer interface [polypeptide binding]; other site 565655001903 catalytic motif [active] 565655001904 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 565655001905 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 565655001906 active site 565655001907 metal binding site [ion binding]; metal-binding site 565655001908 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 565655001909 Protein of unknown function (DUF1027); Region: DUF1027; pfam06265 565655001910 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 565655001911 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 565655001912 active site 565655001913 motif I; other site 565655001914 motif II; other site 565655001915 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 565655001916 Protein of unknown function (DUF1461); Region: DUF1461; pfam07314 565655001917 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 565655001918 tetramer interfaces [polypeptide binding]; other site 565655001919 binuclear metal-binding site [ion binding]; other site 565655001920 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 565655001921 Zn2+ binding site [ion binding]; other site 565655001922 Mg2+ binding site [ion binding]; other site 565655001923 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 565655001924 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 565655001925 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 565655001926 peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903 565655001927 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 565655001928 active site 565655001929 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 565655001930 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 565655001931 pyridoxal 5'-phosphate binding site [chemical binding]; other site 565655001932 homodimer interface [polypeptide binding]; other site 565655001933 catalytic residue [active] 565655001934 general stress protein 13; Validated; Region: PRK08059 565655001935 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 565655001936 RNA binding site [nucleotide binding]; other site 565655001937 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 565655001938 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 565655001939 motif II; other site 565655001940 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 565655001941 Ligand Binding Site [chemical binding]; other site 565655001942 Predicted membrane protein [General function prediction only]; Region: COG4194 565655001943 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 565655001944 DNA-binding site [nucleotide binding]; DNA binding site 565655001945 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 565655001946 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 565655001947 trimer interface [polypeptide binding]; other site 565655001948 active site 565655001949 G bulge; other site 565655001950 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 565655001951 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 565655001952 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 565655001953 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 565655001954 Phosphotransferase enzyme family; Region: APH; pfam01636 565655001955 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 565655001956 active site 565655001957 substrate binding site [chemical binding]; other site 565655001958 ATP binding site [chemical binding]; other site 565655001959 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 565655001960 substrate binding site [chemical binding]; other site 565655001961 Acyl-ACP thioesterase; Region: Acyl-ACP_TE; pfam01643 565655001962 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 565655001963 active site 565655001964 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 565655001965 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 565655001966 active site 565655001967 homotetramer interface [polypeptide binding]; other site 565655001968 homodimer interface [polypeptide binding]; other site 565655001969 Protein of unknown function DUF72; Region: DUF72; pfam01904 565655001970 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 565655001971 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 565655001972 active site 565655001973 motif I; other site 565655001974 motif II; other site 565655001975 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 565655001976 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4696 565655001977 metal binding site [ion binding]; metal-binding site 565655001978 aspartate kinase; Reviewed; Region: PRK09034 565655001979 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 565655001980 putative catalytic residues [active] 565655001981 putative nucleotide binding site [chemical binding]; other site 565655001982 putative aspartate binding site [chemical binding]; other site 565655001983 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 565655001984 allosteric regulatory residue; other site 565655001985 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 565655001986 Septation ring formation regulator, EzrA; Region: EzrA; pfam06160 565655001987 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 565655001988 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 565655001989 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 565655001990 catalytic residue [active] 565655001991 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 565655001992 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 565655001993 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 565655001994 Ligand Binding Site [chemical binding]; other site 565655001995 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 565655001996 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 565655001997 CoA binding domain; Region: CoA_binding; pfam02629 565655001998 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 565655001999 dimer interface [polypeptide binding]; other site 565655002000 catalytic triad [active] 565655002001 peroxidatic and resolving cysteines [active] 565655002002 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 565655002003 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 565655002004 active site 565655002005 HIGH motif; other site 565655002006 nucleotide binding site [chemical binding]; other site 565655002007 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 565655002008 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 565655002009 active site 565655002010 KMSKS motif; other site 565655002011 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 565655002012 tRNA binding surface [nucleotide binding]; other site 565655002013 anticodon binding site; other site 565655002014 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 565655002015 folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499 565655002016 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 565655002017 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 565655002018 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 565655002019 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 565655002020 motif II; other site 565655002021 hypothetical protein; Reviewed; Region: PRK00024 565655002022 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 565655002023 MPN+ (JAMM) motif; other site 565655002024 Zinc-binding site [ion binding]; other site 565655002025 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 565655002026 DNA-binding site [nucleotide binding]; DNA binding site 565655002027 RNA-binding motif; other site 565655002028 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 565655002029 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 565655002030 non-specific DNA binding site [nucleotide binding]; other site 565655002031 salt bridge; other site 565655002032 sequence-specific DNA binding site [nucleotide binding]; other site 565655002033 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 565655002034 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 565655002035 non-specific DNA binding site [nucleotide binding]; other site 565655002036 salt bridge; other site 565655002037 sequence-specific DNA binding site [nucleotide binding]; other site 565655002038 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 565655002039 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 565655002040 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 565655002041 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 565655002042 dimer interface [polypeptide binding]; other site 565655002043 conserved gate region; other site 565655002044 putative PBP binding loops; other site 565655002045 ABC-ATPase subunit interface; other site 565655002046 Protein of unknown function, DUF624; Region: DUF624; cl02369 565655002047 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 565655002048 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 565655002049 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 565655002050 N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789 565655002051 active site 565655002052 catalytic site [active] 565655002053 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; pfam09261 565655002054 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 565655002055 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 565655002056 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 565655002057 Protein of unknown function (DUF1447); Region: DUF1447; pfam07288 565655002058 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 565655002059 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 565655002060 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 565655002061 Walker A/P-loop; other site 565655002062 ATP binding site [chemical binding]; other site 565655002063 Q-loop/lid; other site 565655002064 ABC transporter signature motif; other site 565655002065 Walker B; other site 565655002066 D-loop; other site 565655002067 H-loop/switch region; other site 565655002068 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 565655002069 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 565655002070 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 565655002071 Walker A/P-loop; other site 565655002072 ATP binding site [chemical binding]; other site 565655002073 Q-loop/lid; other site 565655002074 ABC transporter signature motif; other site 565655002075 Walker B; other site 565655002076 D-loop; other site 565655002077 H-loop/switch region; other site 565655002078 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 565655002079 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 565655002080 trimer interface [polypeptide binding]; other site 565655002081 putative metal binding site [ion binding]; other site 565655002082 Clp protease; Region: CLP_protease; pfam00574 565655002083 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 565655002084 oligomer interface [polypeptide binding]; other site 565655002085 active site residues [active] 565655002086 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 565655002087 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 565655002088 active site 565655002089 catalytic site [active] 565655002090 metal binding site [ion binding]; metal-binding site 565655002091 dimer interface [polypeptide binding]; other site 565655002092 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 565655002093 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 565655002094 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 565655002095 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 565655002096 HflX GTPase family; Region: HflX; cd01878 565655002097 G1 box; other site 565655002098 GTP/Mg2+ binding site [chemical binding]; other site 565655002099 Switch I region; other site 565655002100 G2 box; other site 565655002101 G3 box; other site 565655002102 Switch II region; other site 565655002103 G4 box; other site 565655002104 G5 box; other site 565655002105 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 565655002106 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 565655002107 DNA binding residues [nucleotide binding] 565655002108 putative dimer interface [polypeptide binding]; other site 565655002109 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 565655002110 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 565655002111 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 565655002112 Protein of unknown function (DUF1093); Region: DUF1093; cl02185 565655002113 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 565655002114 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 565655002115 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 565655002116 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 565655002117 active site 565655002118 trimer interface [polypeptide binding]; other site 565655002119 allosteric site; other site 565655002120 active site lid [active] 565655002121 hexamer (dimer of trimers) interface [polypeptide binding]; other site 565655002122 magnesium transport protein MgtC; Provisional; Region: PRK15385 565655002123 MgtC family; Region: MgtC; pfam02308 565655002124 Integral membrane protein DUF92; Region: DUF92; pfam01940 565655002125 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 565655002126 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 565655002127 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 565655002128 Mga helix-turn-helix domain; Region: Mga; pfam05043 565655002129 glycerol kinase; Provisional; Region: glpK; PRK00047 565655002130 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 565655002131 N- and C-terminal domain interface [polypeptide binding]; other site 565655002132 active site 565655002133 MgATP binding site [chemical binding]; other site 565655002134 catalytic site [active] 565655002135 metal binding site [ion binding]; metal-binding site 565655002136 glycerol binding site [chemical binding]; other site 565655002137 homotetramer interface [polypeptide binding]; other site 565655002138 homodimer interface [polypeptide binding]; other site 565655002139 FBP binding site [chemical binding]; other site 565655002140 protein IIAGlc interface [polypeptide binding]; other site 565655002141 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 565655002142 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 565655002143 amphipathic channel; other site 565655002144 Asn-Pro-Ala signature motifs; other site 565655002145 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 565655002146 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 565655002147 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 565655002148 dimer interface [polypeptide binding]; other site 565655002149 putative radical transfer pathway; other site 565655002150 diiron center [ion binding]; other site 565655002151 tyrosyl radical; other site 565655002152 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07306 565655002153 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 565655002154 Class I ribonucleotide reductase; Region: RNR_I; cd01679 565655002155 active site 565655002156 dimer interface [polypeptide binding]; other site 565655002157 catalytic residues [active] 565655002158 effector binding site; other site 565655002159 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 565655002160 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 565655002161 catalytic residues [active] 565655002162 FeoA domain; Region: FeoA; pfam04023 565655002163 Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918 565655002164 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 565655002165 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 565655002166 G1 box; other site 565655002167 GTP/Mg2+ binding site [chemical binding]; other site 565655002168 Switch I region; other site 565655002169 G2 box; other site 565655002170 G3 box; other site 565655002171 Switch II region; other site 565655002172 G4 box; other site 565655002173 G5 box; other site 565655002174 Nucleoside recognition; Region: Gate; pfam07670 565655002175 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 565655002176 Nucleoside recognition; Region: Gate; pfam07670 565655002177 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 565655002178 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 565655002179 putative active site [active] 565655002180 putative metal binding site [ion binding]; other site 565655002181 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 565655002182 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 565655002183 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 565655002184 Glycosyl hydrolases family 39; Region: Glyco_hydro_39; pfam01229 565655002185 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 565655002186 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 565655002187 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 565655002188 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 565655002189 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 565655002190 Metal-binding active site; metal-binding site 565655002191 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 565655002192 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 565655002193 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 565655002194 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 565655002195 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 565655002196 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 565655002197 catalytic core [active] 565655002198 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 565655002199 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 565655002200 nucleotide binding site [chemical binding]; other site 565655002201 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 565655002202 HPr interaction site; other site 565655002203 glycerol kinase (GK) interaction site [polypeptide binding]; other site 565655002204 active site 565655002205 phosphorylation site [posttranslational modification] 565655002206 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 565655002207 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 565655002208 active site turn [active] 565655002209 phosphorylation site [posttranslational modification] 565655002210 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 565655002211 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 565655002212 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 565655002213 motif I; other site 565655002214 active site 565655002215 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 565655002216 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 565655002217 motif II; other site 565655002218 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 565655002219 salt bridge; other site 565655002220 non-specific DNA binding site [nucleotide binding]; other site 565655002221 sequence-specific DNA binding site [nucleotide binding]; other site 565655002222 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 565655002223 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 565655002224 Predicted transcriptional regulator [Transcription]; Region: COG4189 565655002225 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 565655002226 dimerization interface [polypeptide binding]; other site 565655002227 putative DNA binding site [nucleotide binding]; other site 565655002228 putative Zn2+ binding site [ion binding]; other site 565655002229 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 565655002230 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 565655002231 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 565655002232 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 565655002233 dimer interface [polypeptide binding]; other site 565655002234 conserved gate region; other site 565655002235 putative PBP binding loops; other site 565655002236 ABC-ATPase subunit interface; other site 565655002237 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 565655002238 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 565655002239 dimer interface [polypeptide binding]; other site 565655002240 conserved gate region; other site 565655002241 putative PBP binding loops; other site 565655002242 ABC-ATPase subunit interface; other site 565655002243 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 565655002244 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 565655002245 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 565655002246 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 565655002247 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 565655002248 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 565655002249 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 565655002250 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 565655002251 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 565655002252 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 565655002253 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 565655002254 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 565655002255 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 565655002256 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 565655002257 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 565655002258 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 565655002259 non-specific DNA binding site [nucleotide binding]; other site 565655002260 salt bridge; other site 565655002261 sequence-specific DNA binding site [nucleotide binding]; other site 565655002262 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 565655002263 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 565655002264 active site 565655002265 motif I; other site 565655002266 motif II; other site 565655002267 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 565655002268 Protein of unknown function (DUF2851); Region: DUF2851; pfam11013 565655002269 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 565655002270 ATP phosphoribosyltransferase, regulatory subunit; Region: hisZ_biosyn_reg; TIGR00443 565655002271 dimer interface [polypeptide binding]; other site 565655002272 motif 1; other site 565655002273 active site 565655002274 motif 2; other site 565655002275 motif 3; other site 565655002276 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 565655002277 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 565655002278 histidinol dehydrogenase; Region: hisD; TIGR00069 565655002279 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 565655002280 NAD binding site [chemical binding]; other site 565655002281 dimerization interface [polypeptide binding]; other site 565655002282 product binding site; other site 565655002283 substrate binding site [chemical binding]; other site 565655002284 zinc binding site [ion binding]; other site 565655002285 catalytic residues [active] 565655002286 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141 565655002287 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 565655002288 pyridoxal 5'-phosphate binding site [chemical binding]; other site 565655002289 homodimer interface [polypeptide binding]; other site 565655002290 catalytic residue [active] 565655002291 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 565655002292 putative active site pocket [active] 565655002293 4-fold oligomerization interface [polypeptide binding]; other site 565655002294 metal binding residues [ion binding]; metal-binding site 565655002295 3-fold/trimer interface [polypeptide binding]; other site 565655002296 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 565655002297 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 565655002298 putative active site [active] 565655002299 oxyanion strand; other site 565655002300 catalytic triad [active] 565655002301 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 565655002302 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 565655002303 catalytic residues [active] 565655002304 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 565655002305 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 565655002306 substrate binding site [chemical binding]; other site 565655002307 glutamase interaction surface [polypeptide binding]; other site 565655002308 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 565655002309 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 565655002310 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 565655002311 metal binding site [ion binding]; metal-binding site 565655002312 Domain of unknown function (DUF305); Region: DUF305; cl17794 565655002313 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807 565655002314 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 565655002315 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 565655002316 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 565655002317 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 565655002318 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 565655002319 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 565655002320 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 565655002321 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 565655002322 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 565655002323 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 565655002324 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 565655002325 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 565655002326 Mga helix-turn-helix domain; Region: Mga; pfam05043 565655002327 HD domain; Region: HD_3; pfam13023 565655002328 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 565655002329 homotrimer interaction site [polypeptide binding]; other site 565655002330 putative active site [active] 565655002331 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 565655002332 MucBP domain; Region: MucBP; pfam06458 565655002333 MucBP domain; Region: MucBP; pfam06458 565655002334 MucBP domain; Region: MucBP; pfam06458 565655002335 MucBP domain; Region: MucBP; pfam06458 565655002336 MucBP domain; Region: MucBP; pfam06458 565655002337 MucBP domain; Region: MucBP; pfam06458 565655002338 MucBP domain; Region: MucBP; pfam06458 565655002339 MucBP domain; Region: MucBP; pfam06458 565655002340 MucBP domain; Region: MucBP; pfam06458 565655002341 MucBP domain; Region: MucBP; pfam06458 565655002342 MucBP domain; Region: MucBP; pfam06458 565655002343 MucBP domain; Region: MucBP; pfam06458 565655002344 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 565655002345 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 565655002346 non-specific DNA binding site [nucleotide binding]; other site 565655002347 salt bridge; other site 565655002348 sequence-specific DNA binding site [nucleotide binding]; other site 565655002349 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 565655002350 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3575 565655002351 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 565655002352 HTH domain; Region: HTH_11; pfam08279 565655002353 Mga helix-turn-helix domain; Region: Mga; pfam05043 565655002354 PRD domain; Region: PRD; pfam00874 565655002355 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 565655002356 active site 565655002357 P-loop; other site 565655002358 phosphorylation site [posttranslational modification] 565655002359 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 565655002360 active site 565655002361 phosphorylation site [posttranslational modification] 565655002362 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 565655002363 active site 565655002364 phosphorylation site [posttranslational modification] 565655002365 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 565655002366 active site 565655002367 P-loop; other site 565655002368 phosphorylation site [posttranslational modification] 565655002369 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 565655002370 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 565655002371 alpha-mannosidase; Provisional; Region: PRK09819 565655002372 N-terminal catalytic domain of Escherichia coli alpha-mannosidase MngB and its bacterial homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_EcMngB_like; cd10815 565655002373 active site 565655002374 metal binding site [ion binding]; metal-binding site 565655002375 catalytic site [active] 565655002376 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 565655002377 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 565655002378 Transcriptional regulator [Transcription]; Region: LysR; COG0583 565655002379 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 565655002380 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 565655002381 dimerization interface [polypeptide binding]; other site 565655002382 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 565655002383 C4-dicarboxylate transporters of the Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_C4-dicarb_trans; cd09325 565655002384 gating phenylalanine in ion channel; other site 565655002385 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 565655002386 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 565655002387 tetramer (dimer of dimers) interface [polypeptide binding]; other site 565655002388 NAD binding site [chemical binding]; other site 565655002389 dimer interface [polypeptide binding]; other site 565655002390 substrate binding site [chemical binding]; other site 565655002391 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 565655002392 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 565655002393 FtsX-like permease family; Region: FtsX; pfam02687 565655002394 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 565655002395 ABC transporter; Region: ABC_tran; pfam00005 565655002396 Q-loop/lid; other site 565655002397 ABC transporter signature motif; other site 565655002398 Walker B; other site 565655002399 D-loop; other site 565655002400 H-loop/switch region; other site 565655002401 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 565655002402 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 565655002403 inner membrane transporter YjeM; Provisional; Region: PRK15238 565655002404 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08115 565655002405 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 565655002406 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 565655002407 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 565655002408 active site 565655002409 AAA domain; Region: AAA_33; pfam13671 565655002410 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 565655002411 active site 565655002412 RelB antitoxin; Region: RelB; cl01171 565655002413 SynChlorMet cassette protein ScmC; Region: SCM_chp_ScmC; TIGR04249 565655002414 PemK-like protein; Region: PemK; pfam02452 565655002415 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 565655002416 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 565655002417 EDD domain protein, DegV family; Region: DegV; TIGR00762 565655002418 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 565655002419 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 565655002420 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 565655002421 active site 565655002422 phosphorylation site [posttranslational modification] 565655002423 intermolecular recognition site; other site 565655002424 dimerization interface [polypeptide binding]; other site 565655002425 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 565655002426 DNA binding site [nucleotide binding] 565655002427 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 565655002428 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 565655002429 dimerization interface [polypeptide binding]; other site 565655002430 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 565655002431 putative active site [active] 565655002432 heme pocket [chemical binding]; other site 565655002433 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 565655002434 dimer interface [polypeptide binding]; other site 565655002435 phosphorylation site [posttranslational modification] 565655002436 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 565655002437 ATP binding site [chemical binding]; other site 565655002438 Mg2+ binding site [ion binding]; other site 565655002439 G-X-G motif; other site 565655002440 YycH protein; Region: YycH; pfam07435 565655002441 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863 565655002442 YycH protein; Region: YycI; pfam09648 565655002443 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 565655002444 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 565655002445 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 565655002446 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 565655002447 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 565655002448 putative active site [active] 565655002449 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 565655002450 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 565655002451 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 565655002452 beta-galactosidase; Region: BGL; TIGR03356 565655002453 CAAX protease self-immunity; Region: Abi; pfam02517 565655002454 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 565655002455 oligomerisation interface [polypeptide binding]; other site 565655002456 mobile loop; other site 565655002457 roof hairpin; other site 565655002458 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 565655002459 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 565655002460 ring oligomerisation interface [polypeptide binding]; other site 565655002461 ATP/Mg binding site [chemical binding]; other site 565655002462 stacking interactions; other site 565655002463 hinge regions; other site 565655002464 Uncharacterized protein/domain associated with GTPases [Function unknown]; Region: COG3597 565655002465 N-glycosyltransferase; Provisional; Region: PRK11204 565655002466 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 565655002467 DXD motif; other site 565655002468 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 565655002469 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 565655002470 DNA-binding site [nucleotide binding]; DNA binding site 565655002471 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 565655002472 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 565655002473 beta-galactosidase; Region: BGL; TIGR03356 565655002474 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 565655002475 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 565655002476 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Sulfolobus solfataricus (Ss) and its homologs from archaea and bacteria; Region: NTP-PPase_SsMazG; cd11535 565655002477 metal binding site [ion binding]; metal-binding site 565655002478 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 565655002479 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 565655002480 Coenzyme A binding pocket [chemical binding]; other site 565655002481 Cupin domain; Region: Cupin_2; pfam07883 565655002482 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 565655002483 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 565655002484 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 565655002485 EamA-like transporter family; Region: EamA; pfam00892 565655002486 EamA-like transporter family; Region: EamA; pfam00892 565655002487 Bacterial SH3 domain; Region: SH3_3; pfam08239 565655002488 Bacterial SH3 domain; Region: SH3_3; pfam08239 565655002489 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 565655002490 NlpC/P60 family; Region: NLPC_P60; pfam00877 565655002491 myosin-cross-reactive antigen; Provisional; Region: PRK13977 565655002492 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 565655002493 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 565655002494 DNA binding residues [nucleotide binding] 565655002495 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 565655002496 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 565655002497 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 565655002498 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 565655002499 active site 565655002500 motif I; other site 565655002501 motif II; other site 565655002502 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 565655002503 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 565655002504 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 565655002505 peptide binding site [polypeptide binding]; other site 565655002506 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 565655002507 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 565655002508 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 565655002509 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 565655002510 putative active site [active] 565655002511 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 565655002512 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 565655002513 active site turn [active] 565655002514 phosphorylation site [posttranslational modification] 565655002515 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 565655002516 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 565655002517 HPr interaction site; other site 565655002518 glycerol kinase (GK) interaction site [polypeptide binding]; other site 565655002519 active site 565655002520 phosphorylation site [posttranslational modification] 565655002521 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 565655002522 beta-galactosidase; Region: BGL; TIGR03356 565655002523 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 565655002524 beta-galactosidase; Region: BGL; TIGR03356 565655002525 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 565655002526 DNA-binding site [nucleotide binding]; DNA binding site 565655002527 RNA-binding motif; other site 565655002528 SnoaL-like domain; Region: SnoaL_2; pfam12680 565655002529 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 565655002530 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 565655002531 active site 565655002532 metal binding site [ion binding]; metal-binding site 565655002533 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 565655002534 Protein of unknown function (DUF2810); Region: DUF2810; cl08159 565655002535 Surface antigen [General function prediction only]; Region: COG3942 565655002536 CHAP domain; Region: CHAP; pfam05257 565655002537 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 565655002538 Part of AAA domain; Region: AAA_19; pfam13245 565655002539 Family description; Region: UvrD_C_2; pfam13538 565655002540 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 565655002541 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 565655002542 active site 565655002543 FMN binding site [chemical binding]; other site 565655002544 substrate binding site [chemical binding]; other site 565655002545 homotetramer interface [polypeptide binding]; other site 565655002546 catalytic residue [active] 565655002547 Predicted transcriptional regulators [Transcription]; Region: COG1695 565655002548 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 565655002549 hypothetical protein; Validated; Region: PRK07668 565655002550 Tocopherol cyclase; Region: Tocopherol_cycl; cl14571 565655002551 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 565655002552 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 565655002553 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 565655002554 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 565655002555 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 565655002556 Listerrria innocua Lin0431 is similar to the N-Utilization Substance G (NusG) N terminal (NGN) insert (DII); Region: Lin0431_like; cd09911 565655002557 trimer interface [polypeptide binding]; other site 565655002558 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 565655002559 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 565655002560 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 565655002561 metal binding site [ion binding]; metal-binding site 565655002562 active site 565655002563 I-site; other site 565655002564 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 565655002565 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 565655002566 metal binding site [ion binding]; metal-binding site 565655002567 active site 565655002568 I-site; other site 565655002569 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 565655002570 Ligand binding site; other site 565655002571 Putative Catalytic site; other site 565655002572 DXD motif; other site 565655002573 Predicted membrane protein [Function unknown]; Region: COG2246 565655002574 GtrA-like protein; Region: GtrA; pfam04138 565655002575 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 565655002576 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 565655002577 DXD motif; other site 565655002578 PilZ domain; Region: PilZ; pfam07238 565655002579 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily, YbbW-like; solute-binding domain; Region: SLC-NCS1sbd_YbbW-like; cd11485 565655002580 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 565655002581 Na binding site [ion binding]; other site 565655002582 putative substrate binding site [chemical binding]; other site 565655002583 allantoinase; Provisional; Region: PRK08044 565655002584 L-Hydantoinases (L-HYDs) and Allantoinase (ALN); L-Hydantoinases are a member of the dihydropyrimidinase family, which catalyzes the reversible hydrolytic ring opening of dihydropyrimidines and hydantoins (five-membered cyclic diamides used in...; Region: L-HYD_ALN; cd01315 565655002585 active site 565655002586 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 565655002587 putative substrate translocation pore; other site 565655002588 D-galactonate transporter; Region: 2A0114; TIGR00893 565655002589 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 565655002590 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 565655002591 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 565655002592 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 565655002593 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 565655002594 N- and C-terminal domain interface [polypeptide binding]; other site 565655002595 rhamnulokinase; Region: rhamnulo_kin; TIGR02627 565655002596 active site 565655002597 putative catalytic site [active] 565655002598 metal binding site [ion binding]; metal-binding site 565655002599 ATP binding site [chemical binding]; other site 565655002600 carbohydrate binding site [chemical binding]; other site 565655002601 L-rhamnose isomerase; Provisional; Region: PRK01076 565655002602 Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900 565655002603 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 565655002604 intersubunit interface [polypeptide binding]; other site 565655002605 active site 565655002606 Zn2+ binding site [ion binding]; other site 565655002607 L-1,2-propanediol oxidoreductase; Provisional; Region: PRK10624 565655002608 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 565655002609 dimer interface [polypeptide binding]; other site 565655002610 active site 565655002611 metal binding site [ion binding]; metal-binding site 565655002612 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 565655002613 allantoate amidohydrolase; Region: AllC; TIGR03176 565655002614 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 565655002615 active site 565655002616 metal binding site [ion binding]; metal-binding site 565655002617 dimer interface [polypeptide binding]; other site 565655002618 putative allantoin catabolism protein; Region: ura-cupin; TIGR03214 565655002619 Cupin domain; Region: Cupin_2; cl17218 565655002620 Cupin domain; Region: Cupin_2; cl17218 565655002621 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 565655002622 membrane protein FdrA; Validated; Region: PRK06091 565655002623 CoA binding domain; Region: CoA_binding; pfam02629 565655002624 CoA-ligase; Region: Ligase_CoA; pfam00549 565655002625 Protein of unknown function (DUF1116); Region: DUF1116; pfam06545 565655002626 Protein of unknown function (DUF2877); Region: DUF2877; pfam11392 565655002627 carbamate kinase; Reviewed; Region: PRK12686 565655002628 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 565655002629 putative substrate binding site [chemical binding]; other site 565655002630 nucleotide binding site [chemical binding]; other site 565655002631 nucleotide binding site [chemical binding]; other site 565655002632 homodimer interface [polypeptide binding]; other site 565655002633 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 565655002634 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 565655002635 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 565655002636 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 565655002637 catalytic residue [active] 565655002638 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 565655002639 D-galactonate transporter; Region: 2A0114; TIGR00893 565655002640 putative substrate translocation pore; other site 565655002641 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 565655002642 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 565655002643 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 565655002644 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 565655002645 ABC transporter; Region: ABC_tran_2; pfam12848 565655002646 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 565655002647 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 565655002648 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 565655002649 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 565655002650 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 565655002651 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 565655002652 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 565655002653 membrane protein FdrA; Validated; Region: PRK06091 565655002654 CoA binding domain; Region: CoA_binding; pfam02629 565655002655 CoA-ligase; Region: Ligase_CoA; pfam00549 565655002656 Protein of unknown function (DUF1116); Region: DUF1116; pfam06545 565655002657 Protein of unknown function (DUF2877); Region: DUF2877; pfam11392 565655002658 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 565655002659 Major Facilitator Superfamily; Region: MFS_1; pfam07690 565655002660 putative substrate translocation pore; other site 565655002661 carbamate kinase; Reviewed; Region: PRK12686 565655002662 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 565655002663 putative substrate binding site [chemical binding]; other site 565655002664 nucleotide binding site [chemical binding]; other site 565655002665 nucleotide binding site [chemical binding]; other site 565655002666 homodimer interface [polypeptide binding]; other site 565655002667 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 565655002668 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 565655002669 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 565655002670 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 565655002671 dimer interface [polypeptide binding]; other site 565655002672 ssDNA binding site [nucleotide binding]; other site 565655002673 tetramer (dimer of dimers) interface [polypeptide binding]; other site 565655002674 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 565655002675 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 565655002676 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 565655002677 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 565655002678 peptide binding site [polypeptide binding]; other site 565655002679 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 565655002680 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 565655002681 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 565655002682 Walker A/P-loop; other site 565655002683 ATP binding site [chemical binding]; other site 565655002684 Q-loop/lid; other site 565655002685 ABC transporter signature motif; other site 565655002686 Walker B; other site 565655002687 D-loop; other site 565655002688 H-loop/switch region; other site 565655002689 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 565655002690 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 565655002691 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 565655002692 Walker A/P-loop; other site 565655002693 ATP binding site [chemical binding]; other site 565655002694 Q-loop/lid; other site 565655002695 ABC transporter signature motif; other site 565655002696 Walker B; other site 565655002697 D-loop; other site 565655002698 H-loop/switch region; other site 565655002699 Transcriptional regulator [Transcription]; Region: LysR; COG0583 565655002700 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 565655002701 LysR substrate binding domain; Region: LysR_substrate; pfam03466 565655002702 dimerization interface [polypeptide binding]; other site 565655002703 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 565655002704 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 565655002705 Lin1944 and related proteins, classical (c) SDRs; Region: Lin1944_like_SDR_c; cd11731 565655002706 putative NAD(P) binding site [chemical binding]; other site 565655002707 homodimer interface [polypeptide binding]; other site 565655002708 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 565655002709 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 565655002710 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 565655002711 active site 565655002712 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 565655002713 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 565655002714 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 565655002715 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 565655002716 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 565655002717 putative NAD(P) binding site [chemical binding]; other site 565655002718 conserved hypothetical protein; Region: TIGR02328 565655002719 Pyrimidine dimer DNA glycosylase; Region: Pyr_excise; pfam03013 565655002720 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 565655002721 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 565655002722 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 565655002723 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 565655002724 putative septicolysin, cholesterol-dependent cytolysin family and related proteins; Region: septicolysin_like; cd12208 565655002725 oligomer interface [polypeptide binding]; other site 565655002726 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 565655002727 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 565655002728 peptide binding site [polypeptide binding]; other site 565655002729 Uncharacterized conserved protein [Function unknown]; Region: COG1912 565655002730 hypothetical protein; Provisional; Region: PRK13661 565655002731 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 565655002732 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 565655002733 Walker A/P-loop; other site 565655002734 ATP binding site [chemical binding]; other site 565655002735 Q-loop/lid; other site 565655002736 ABC transporter signature motif; other site 565655002737 Walker B; other site 565655002738 D-loop; other site 565655002739 H-loop/switch region; other site 565655002740 ATP-binding cassette cobalt transporter; Region: DUF3744; pfam12558 565655002741 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 565655002742 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 565655002743 Walker A/P-loop; other site 565655002744 ATP binding site [chemical binding]; other site 565655002745 Q-loop/lid; other site 565655002746 ABC transporter signature motif; other site 565655002747 Walker B; other site 565655002748 D-loop; other site 565655002749 H-loop/switch region; other site 565655002750 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 565655002751 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 565655002752 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 565655002753 Walker A/P-loop; other site 565655002754 ATP binding site [chemical binding]; other site 565655002755 Q-loop/lid; other site 565655002756 ABC transporter signature motif; other site 565655002757 Walker B; other site 565655002758 D-loop; other site 565655002759 H-loop/switch region; other site 565655002760 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 565655002761 Predicted metalloprotease [General function prediction only]; Region: COG2321 565655002762 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 565655002763 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 565655002764 PRD domain; Region: PRD; pfam00874 565655002765 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 565655002766 active site 565655002767 P-loop; other site 565655002768 phosphorylation site [posttranslational modification] 565655002769 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 565655002770 active site 565655002771 phosphorylation site [posttranslational modification] 565655002772 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 565655002773 active site 565655002774 phosphorylation site [posttranslational modification] 565655002775 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 565655002776 active site 565655002777 P-loop; other site 565655002778 phosphorylation site [posttranslational modification] 565655002779 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 565655002780 hypothetical protein; Provisional; Region: PRK02947 565655002781 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 565655002782 putative active site [active] 565655002783 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 565655002784 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 565655002785 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 565655002786 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 565655002787 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 565655002788 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 565655002789 dimer interface [polypeptide binding]; other site 565655002790 conserved gate region; other site 565655002791 putative PBP binding loops; other site 565655002792 ABC-ATPase subunit interface; other site 565655002793 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 565655002794 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 565655002795 dimer interface [polypeptide binding]; other site 565655002796 conserved gate region; other site 565655002797 putative PBP binding loops; other site 565655002798 ABC-ATPase subunit interface; other site 565655002799 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 565655002800 N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789 565655002801 active site 565655002802 catalytic site [active] 565655002803 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; pfam09261 565655002804 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 565655002805 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 565655002806 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 565655002807 active site 565655002808 catalytic tetrad [active] 565655002809 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 565655002810 dimanganese center [ion binding]; other site 565655002811 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 565655002812 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 565655002813 Cl binding site [ion binding]; other site 565655002814 oligomer interface [polypeptide binding]; other site 565655002815 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 565655002816 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 565655002817 dimer interface [polypeptide binding]; other site 565655002818 conserved gate region; other site 565655002819 putative PBP binding loops; other site 565655002820 ABC-ATPase subunit interface; other site 565655002821 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 565655002822 dimer interface [polypeptide binding]; other site 565655002823 conserved gate region; other site 565655002824 putative PBP binding loops; other site 565655002825 ABC-ATPase subunit interface; other site 565655002826 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 565655002827 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 565655002828 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 565655002829 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 565655002830 Predicted small secreted protein [Function unknown]; Region: COG5584 565655002831 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 565655002832 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 565655002833 oligomer interface [polypeptide binding]; other site 565655002834 active site 565655002835 metal binding site [ion binding]; metal-binding site 565655002836 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 565655002837 catalytic residues [active] 565655002838 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 565655002839 Ligand Binding Site [chemical binding]; other site 565655002840 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 565655002841 putative tRNA-binding site [nucleotide binding]; other site 565655002842 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 565655002843 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 565655002844 protein binding site [polypeptide binding]; other site 565655002845 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 565655002846 GIY-YIG domain of uncharacterized proteins from bacteria and their eukaryotic homologs; Region: GIY-YIG_COG3680; cd10440 565655002847 GIY-YIG motif/motif A; other site 565655002848 putative active site [active] 565655002849 putative metal binding site [ion binding]; other site 565655002850 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 565655002851 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 565655002852 dimerization interface 3.5A [polypeptide binding]; other site 565655002853 active site 565655002854 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 565655002855 active site 565655002856 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 565655002857 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 565655002858 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 565655002859 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 565655002860 Cupin domain; Region: Cupin_2; cl17218 565655002861 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 565655002862 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 565655002863 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 565655002864 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 565655002865 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 565655002866 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 565655002867 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 565655002868 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 565655002869 Major Facilitator Superfamily; Region: MFS_1; pfam07690 565655002870 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 565655002871 putative substrate translocation pore; other site 565655002872 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 565655002873 PemK-like protein; Region: PemK; pfam02452 565655002874 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 565655002875 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 565655002876 Isochorismatase family; Region: Isochorismatase; pfam00857 565655002877 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 565655002878 catalytic triad [active] 565655002879 conserved cis-peptide bond; other site 565655002880 Enterocin A Immunity; Region: EntA_Immun; pfam08951 565655002881 Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225 565655002882 cytosine deaminase; Provisional; Region: PRK05985 565655002883 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 565655002884 active site 565655002885 WxL domain surface cell wall-binding; Region: WxL; pfam13731 565655002886 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 565655002887 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 565655002888 non-specific DNA binding site [nucleotide binding]; other site 565655002889 salt bridge; other site 565655002890 sequence-specific DNA binding site [nucleotide binding]; other site 565655002891 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 565655002892 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014 565655002893 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014 565655002894 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 565655002895 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 565655002896 Substrate-binding site [chemical binding]; other site 565655002897 Substrate specificity [chemical binding]; other site 565655002898 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 565655002899 non-specific DNA binding site [nucleotide binding]; other site 565655002900 salt bridge; other site 565655002901 sequence-specific DNA binding site [nucleotide binding]; other site 565655002902 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 565655002903 ApbE family; Region: ApbE; pfam02424 565655002904 Predicted flavoprotein [General function prediction only]; Region: COG0431 565655002905 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 565655002906 Predicted flavoprotein [General function prediction only]; Region: COG0431 565655002907 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 565655002908 PAS domain; Region: PAS_10; pfam13596 565655002909 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 565655002910 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 565655002911 HTH domain; Region: HTH_11; pfam08279 565655002912 PRD domain; Region: PRD; pfam00874 565655002913 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 565655002914 active site 565655002915 P-loop; other site 565655002916 phosphorylation site [posttranslational modification] 565655002917 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 565655002918 active site 565655002919 phosphorylation site [posttranslational modification] 565655002920 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 565655002921 active site 565655002922 P-loop; other site 565655002923 phosphorylation site [posttranslational modification] 565655002924 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 565655002925 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 565655002926 intersubunit interface [polypeptide binding]; other site 565655002927 active site 565655002928 zinc binding site [ion binding]; other site 565655002929 Na+ binding site [ion binding]; other site 565655002930 AAA domain; Region: AAA_18; pfam13238 565655002931 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 565655002932 Domain of unknown function (DUF389); Region: DUF389; pfam04087 565655002933 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 565655002934 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 565655002935 nudix motif; other site 565655002936 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 565655002937 Transcriptional regulators [Transcription]; Region: PurR; COG1609 565655002938 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 565655002939 DNA binding site [nucleotide binding] 565655002940 domain linker motif; other site 565655002941 Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542 565655002942 dimerization interface [polypeptide binding]; other site 565655002943 ligand binding site [chemical binding]; other site 565655002944 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 565655002945 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 565655002946 active site turn [active] 565655002947 phosphorylation site [posttranslational modification] 565655002948 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 565655002949 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 565655002950 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 565655002951 substrate binding [chemical binding]; other site 565655002952 active site 565655002953 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 565655002954 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 565655002955 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 565655002956 ligand binding site [chemical binding]; other site 565655002957 flexible hinge region; other site 565655002958 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 565655002959 Predicted membrane protein [Function unknown]; Region: COG2364 565655002960 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 565655002961 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 565655002962 Arsenical resistance operon trans-acting repressor ArsD; Region: ArsD; pfam06953 565655002963 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 565655002964 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 565655002965 Putative catalytic polysaccharide deacetylase domain of uncharacterized protein yadE and similar proteins; Region: CE4_yadE_5s; cd10966 565655002966 putative active site [active] 565655002967 putative metal binding site [ion binding]; other site 565655002968 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 565655002969 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 565655002970 Walker A/P-loop; other site 565655002971 ATP binding site [chemical binding]; other site 565655002972 Q-loop/lid; other site 565655002973 ABC transporter signature motif; other site 565655002974 Walker B; other site 565655002975 D-loop; other site 565655002976 H-loop/switch region; other site 565655002977 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 565655002978 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 565655002979 Domain of unknown function (DUF1858); Region: DUF1858; pfam08984 565655002980 Uncharacterized conserved protein [Function unknown]; Region: COG2461 565655002981 Family of unknown function (DUF438); Region: DUF438; pfam04282 565655002982 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 565655002983 transcriptional antiterminator BglG; Provisional; Region: PRK09772 565655002984 CAT RNA binding domain; Region: CAT_RBD; smart01061 565655002985 PRD domain; Region: PRD; pfam00874 565655002986 PRD domain; Region: PRD; pfam00874 565655002987 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 565655002988 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 565655002989 active site turn [active] 565655002990 phosphorylation site [posttranslational modification] 565655002991 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 565655002992 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 565655002993 HPr interaction site; other site 565655002994 glycerol kinase (GK) interaction site [polypeptide binding]; other site 565655002995 active site 565655002996 phosphorylation site [posttranslational modification] 565655002997 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 565655002998 Sulfatase; Region: Sulfatase; cl17466 565655002999 anaerobic sulfatase-maturase; Provisional; Region: PRK13758 565655003000 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 565655003001 FeS/SAM binding site; other site 565655003002 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 565655003003 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 565655003004 Uncharacterized conserved protein [Function unknown]; Region: COG1262 565655003005 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 565655003006 Domain of unknown function (DUF378); Region: DUF378; pfam04070 565655003007 YrhK-like protein; Region: YrhK; pfam14145 565655003008 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 565655003009 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 565655003010 NAD binding site [chemical binding]; other site 565655003011 catalytic Zn binding site [ion binding]; other site 565655003012 structural Zn binding site [ion binding]; other site 565655003013 Isochorismatase family; Region: Isochorismatase; pfam00857 565655003014 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 565655003015 catalytic triad [active] 565655003016 conserved cis-peptide bond; other site 565655003017 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 565655003018 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 565655003019 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 565655003020 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 565655003021 dimer interface [polypeptide binding]; other site 565655003022 conserved gate region; other site 565655003023 putative PBP binding loops; other site 565655003024 ABC-ATPase subunit interface; other site 565655003025 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 565655003026 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 565655003027 dimer interface [polypeptide binding]; other site 565655003028 conserved gate region; other site 565655003029 putative PBP binding loops; other site 565655003030 ABC-ATPase subunit interface; other site 565655003031 Transcriptional regulators [Transcription]; Region: PurR; COG1609 565655003032 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 565655003033 DNA binding site [nucleotide binding] 565655003034 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 565655003035 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 565655003036 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 565655003037 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 565655003038 Melibiase; Region: Melibiase; pfam02065 565655003039 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 565655003040 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 565655003041 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 565655003042 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 565655003043 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 565655003044 putative substrate binding site [chemical binding]; other site 565655003045 putative ATP binding site [chemical binding]; other site 565655003046 dipeptidase PepV; Reviewed; Region: PRK07318 565655003047 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 565655003048 active site 565655003049 metal binding site [ion binding]; metal-binding site 565655003050 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 565655003051 dimer interface [polypeptide binding]; other site 565655003052 FMN binding site [chemical binding]; other site 565655003053 NADPH bind site [chemical binding]; other site 565655003054 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 565655003055 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 565655003056 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 565655003057 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 565655003058 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 565655003059 motif II; other site 565655003060 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 565655003061 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 565655003062 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 565655003063 Protein of unknown function DUF58; Region: DUF58; pfam01882 565655003064 MoxR-like ATPases [General function prediction only]; Region: COG0714 565655003065 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 565655003066 Walker A motif; other site 565655003067 ATP binding site [chemical binding]; other site 565655003068 Walker B motif; other site 565655003069 arginine finger; other site 565655003070 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 565655003071 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 565655003072 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 565655003073 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 565655003074 active site 565655003075 motif I; other site 565655003076 motif II; other site 565655003077 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 565655003078 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 565655003079 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 565655003080 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 565655003081 DNA-binding site [nucleotide binding]; DNA binding site 565655003082 Transcriptional regulators [Transcription]; Region: PurR; COG1609 565655003083 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 565655003084 ligand binding site [chemical binding]; other site 565655003085 dimerization interface [polypeptide binding]; other site 565655003086 Uncharacterized conserved protein [Function unknown]; Region: COG3538 565655003087 Protein of unknown function (DUF1237); Region: DUF1237; pfam06824 565655003088 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 565655003089 N-terminal catalytic domain of SPGH38, a putative alpha-mannosidase of Streptococcus pyogenes, and its prokaryotic homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_SpGH38_like; cd10814 565655003090 active site 565655003091 metal binding site [ion binding]; metal-binding site 565655003092 homodimer interface [polypeptide binding]; other site 565655003093 catalytic site [active] 565655003094 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 565655003095 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 565655003096 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 565655003097 nucleotide binding site [chemical binding]; other site 565655003098 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 565655003099 beta-galactosidase; Region: BGL; TIGR03356 565655003100 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 565655003101 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 565655003102 dimer interface [polypeptide binding]; other site 565655003103 conserved gate region; other site 565655003104 ABC-ATPase subunit interface; other site 565655003105 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 565655003106 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 565655003107 dimer interface [polypeptide binding]; other site 565655003108 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 565655003109 ABC-ATPase subunit interface; other site 565655003110 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 565655003111 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 565655003112 Domain of unknown function (DUF3502); Region: DUF3502; pfam12010 565655003113 Protein of unknown function, DUF624; Region: DUF624; cl02369 565655003114 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 565655003115 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 565655003116 Histidine kinase; Region: His_kinase; pfam06580 565655003117 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 565655003118 ATP binding site [chemical binding]; other site 565655003119 Mg2+ binding site [ion binding]; other site 565655003120 G-X-G motif; other site 565655003121 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 565655003122 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 565655003123 active site 565655003124 phosphorylation site [posttranslational modification] 565655003125 intermolecular recognition site; other site 565655003126 dimerization interface [polypeptide binding]; other site 565655003127 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 565655003128 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 565655003129 Predicted membrane protein [Function unknown]; Region: COG2364 565655003130 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 565655003131 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 565655003132 putative substrate translocation pore; other site 565655003133 Amino acid permease; Region: AA_permease_2; pfam13520 565655003134 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 565655003135 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162 565655003136 putative ligand binding site [chemical binding]; other site 565655003137 putative NAD binding site [chemical binding]; other site 565655003138 catalytic site [active] 565655003139 YibE/F-like protein; Region: YibE_F; pfam07907 565655003140 YibE/F-like protein; Region: YibE_F; pfam07907 565655003141 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 565655003142 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 565655003143 fumarate reductase flavoprotein subunit; Validated; Region: PRK06481 565655003144 L-aspartate oxidase; Provisional; Region: PRK06175 565655003145 Predicted oxidoreductase [General function prediction only]; Region: COG3573 565655003146 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 565655003147 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 565655003148 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 565655003149 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 565655003150 ABC-ATPase subunit interface; other site 565655003151 dimer interface [polypeptide binding]; other site 565655003152 putative PBP binding regions; other site 565655003153 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 565655003154 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 565655003155 metal binding site [ion binding]; metal-binding site 565655003156 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 565655003157 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 565655003158 putative active site [active] 565655003159 putative metal binding site [ion binding]; other site 565655003160 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 565655003161 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 565655003162 active site 565655003163 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 565655003164 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 565655003165 putative active site [active] 565655003166 putative metal binding site [ion binding]; other site 565655003167 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 565655003168 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 565655003169 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 565655003170 S-adenosylmethionine binding site [chemical binding]; other site 565655003171 Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529 565655003172 putative active site [active] 565655003173 homoserine O-succinyltransferase; Provisional; Region: PRK05368 565655003174 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 565655003175 proposed active site lysine [active] 565655003176 conserved cys residue [active] 565655003177 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 565655003178 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 565655003179 pyridoxal 5'-phosphate binding site [chemical binding]; other site 565655003180 homodimer interface [polypeptide binding]; other site 565655003181 catalytic residue [active] 565655003182 cystathionine gamma-synthase; Reviewed; Region: PRK08247 565655003183 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 565655003184 homodimer interface [polypeptide binding]; other site 565655003185 substrate-cofactor binding pocket; other site 565655003186 pyridoxal 5'-phosphate binding site [chemical binding]; other site 565655003187 catalytic residue [active] 565655003188 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 565655003189 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 565655003190 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 565655003191 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 565655003192 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 565655003193 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 565655003194 dimer interface [polypeptide binding]; other site 565655003195 conserved gate region; other site 565655003196 putative PBP binding loops; other site 565655003197 ABC-ATPase subunit interface; other site 565655003198 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 565655003199 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 565655003200 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 565655003201 dimer interface [polypeptide binding]; other site 565655003202 conserved gate region; other site 565655003203 putative PBP binding loops; other site 565655003204 ABC-ATPase subunit interface; other site 565655003205 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 565655003206 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 565655003207 Walker A/P-loop; other site 565655003208 ATP binding site [chemical binding]; other site 565655003209 Q-loop/lid; other site 565655003210 ABC transporter signature motif; other site 565655003211 Walker B; other site 565655003212 D-loop; other site 565655003213 H-loop/switch region; other site 565655003214 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 565655003215 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 565655003216 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 565655003217 Walker A/P-loop; other site 565655003218 ATP binding site [chemical binding]; other site 565655003219 Q-loop/lid; other site 565655003220 ABC transporter signature motif; other site 565655003221 Walker B; other site 565655003222 D-loop; other site 565655003223 H-loop/switch region; other site 565655003224 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 565655003225 OsmC-like protein; Region: OsmC; pfam02566 565655003226 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 565655003227 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 565655003228 ligand binding site [chemical binding]; other site 565655003229 flexible hinge region; other site 565655003230 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 565655003231 non-specific DNA interactions [nucleotide binding]; other site 565655003232 DNA binding site [nucleotide binding] 565655003233 sequence specific DNA binding site [nucleotide binding]; other site 565655003234 putative cAMP binding site [chemical binding]; other site 565655003235 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 565655003236 Major Facilitator Superfamily; Region: MFS_1; pfam07690 565655003237 putative substrate translocation pore; other site 565655003238 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 565655003239 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 565655003240 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 565655003241 non-specific DNA binding site [nucleotide binding]; other site 565655003242 salt bridge; other site 565655003243 sequence-specific DNA binding site [nucleotide binding]; other site 565655003244 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 565655003245 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 565655003246 active site 565655003247 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 565655003248 AAA domain; Region: AAA_17; pfam13207 565655003249 AAA domain; Region: AAA_18; pfam13238 565655003250 Tetratrico peptide repeat; Region: TPR_5; pfam12688 565655003251 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 565655003252 binding surface 565655003253 TPR motif; other site 565655003254 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 565655003255 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 565655003256 Coenzyme A binding pocket [chemical binding]; other site 565655003257 V-type ATP synthase subunit I; Validated; Region: PRK05771 565655003258 V-type ATP synthase subunit K; Validated; Region: PRK06558 565655003259 ATP synthase subunit C; Region: ATP-synt_C; pfam00137 565655003260 ATP synthase subunit C; Region: ATP-synt_C; pfam00137 565655003261 Archaeal/vacuolar-type H+-ATPase subunit C [Energy production and conversion]; Region: NtpC; COG1527 565655003262 V-type ATP synthase subunit C; Provisional; Region: PRK01198; cl00660 565655003263 ATP synthase (F/14-kDa) subunit; Region: ATP-synt_F; cl00632 565655003264 V-type ATP synthase subunit A; Provisional; Region: PRK04192 565655003265 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 565655003266 V/A-type ATP synthase catalytic subunit A. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_A; cd01134 565655003267 Walker A motif/ATP binding site; other site 565655003268 Walker B motif; other site 565655003269 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 565655003270 V-type ATP synthase subunit B; Provisional; Region: PRK04196 565655003271 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 565655003272 V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_B; cd01135 565655003273 Walker A motif homologous position; other site 565655003274 Walker B motif; other site 565655003275 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 565655003276 V-type ATP synthase subunit D; Reviewed; Region: PRK00373 565655003277 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 565655003278 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 565655003279 MarR family; Region: MarR_2; pfam12802 565655003280 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 565655003281 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 565655003282 putative active site [active] 565655003283 putative FMN binding site [chemical binding]; other site 565655003284 putative substrate binding site [chemical binding]; other site 565655003285 putative catalytic residue [active] 565655003286 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 565655003287 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 565655003288 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 565655003289 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 565655003290 conserved gate region; other site 565655003291 dimer interface [polypeptide binding]; other site 565655003292 putative PBP binding loops; other site 565655003293 ABC-ATPase subunit interface; other site 565655003294 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 565655003295 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 565655003296 dimer interface [polypeptide binding]; other site 565655003297 conserved gate region; other site 565655003298 putative PBP binding loops; other site 565655003299 ABC-ATPase subunit interface; other site 565655003300 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033 565655003301 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 565655003302 transcriptional antiterminator BglG; Provisional; Region: PRK09772 565655003303 CAT RNA binding domain; Region: CAT_RBD; smart01061 565655003304 PRD domain; Region: PRD; pfam00874 565655003305 PRD domain; Region: PRD; pfam00874 565655003306 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 565655003307 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 565655003308 active site turn [active] 565655003309 phosphorylation site [posttranslational modification] 565655003310 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 565655003311 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 565655003312 HPr interaction site; other site 565655003313 glycerol kinase (GK) interaction site [polypeptide binding]; other site 565655003314 active site 565655003315 phosphorylation site [posttranslational modification] 565655003316 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 565655003317 beta-galactosidase; Region: BGL; TIGR03356 565655003318 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 565655003319 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 565655003320 dimerization interface [polypeptide binding]; other site 565655003321 Histidine kinase; Region: His_kinase; pfam06580 565655003322 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 565655003323 ATP binding site [chemical binding]; other site 565655003324 Mg2+ binding site [ion binding]; other site 565655003325 G-X-G motif; other site 565655003326 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 565655003327 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 565655003328 active site 565655003329 phosphorylation site [posttranslational modification] 565655003330 intermolecular recognition site; other site 565655003331 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 565655003332 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 565655003333 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 565655003334 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 565655003335 dimer interface [polypeptide binding]; other site 565655003336 conserved gate region; other site 565655003337 putative PBP binding loops; other site 565655003338 ABC-ATPase subunit interface; other site 565655003339 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 565655003340 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 565655003341 dimer interface [polypeptide binding]; other site 565655003342 conserved gate region; other site 565655003343 putative PBP binding loops; other site 565655003344 ABC-ATPase subunit interface; other site 565655003345 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 565655003346 Melibiase; Region: Melibiase; pfam02065 565655003347 Uncharacterized conserved protein [Function unknown]; Region: COG3592 565655003348 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 565655003349 Coenzyme A binding pocket [chemical binding]; other site 565655003350 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 565655003351 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 565655003352 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 565655003353 Walker A/P-loop; other site 565655003354 ATP binding site [chemical binding]; other site 565655003355 Q-loop/lid; other site 565655003356 ABC transporter signature motif; other site 565655003357 Walker B; other site 565655003358 D-loop; other site 565655003359 H-loop/switch region; other site 565655003360 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 565655003361 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 565655003362 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 565655003363 Walker A/P-loop; other site 565655003364 ATP binding site [chemical binding]; other site 565655003365 Q-loop/lid; other site 565655003366 ABC transporter signature motif; other site 565655003367 Walker B; other site 565655003368 D-loop; other site 565655003369 H-loop/switch region; other site 565655003370 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 565655003371 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 565655003372 Predicted transcriptional regulator [Transcription]; Region: COG2378 565655003373 HTH domain; Region: HTH_11; pfam08279 565655003374 WYL domain; Region: WYL; pfam13280 565655003375 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 565655003376 dimer interface [polypeptide binding]; other site 565655003377 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 565655003378 Transcriptional regulator [Transcription]; Region: LytR; COG1316 565655003379 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 565655003380 Cation efflux family; Region: Cation_efflux; pfam01545 565655003381 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 565655003382 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 565655003383 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 565655003384 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 565655003385 Soluble P-type ATPase [General function prediction only]; Region: COG4087 565655003386 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 565655003387 Transcriptional regulators [Transcription]; Region: MarR; COG1846 565655003388 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 565655003389 putative DNA binding site [nucleotide binding]; other site 565655003390 putative Zn2+ binding site [ion binding]; other site 565655003391 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 565655003392 dimer interface [polypeptide binding]; other site 565655003393 FMN binding site [chemical binding]; other site 565655003394 Uncharacterized conserved protein [Function unknown]; Region: COG1359 565655003395 Predicted membrane protein [Function unknown]; Region: COG3759 565655003396 Predicted membrane protein [Function unknown]; Region: COG4684 565655003397 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 565655003398 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 565655003399 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 565655003400 TATA element modulatory factor 1 DNA binding; Region: TMF_DNA_bd; pfam12329 565655003401 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 565655003402 NlpC/P60 family; Region: NLPC_P60; pfam00877 565655003403 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 565655003404 Bacterial SH3 domain; Region: SH3_3; pfam08239 565655003405 Bacterial SH3 domain; Region: SH3_3; pfam08239 565655003406 Bacterial SH3 domain; Region: SH3_3; pfam08239 565655003407 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 565655003408 Predicted membrane protein [Function unknown]; Region: COG4905 565655003409 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 565655003410 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 565655003411 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 565655003412 Mga helix-turn-helix domain; Region: Mga; pfam05043 565655003413 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 565655003414 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 565655003415 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 565655003416 Chain length determinant protein; Region: Wzz; cl15801 565655003417 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 565655003418 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 565655003419 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 565655003420 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 565655003421 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 565655003422 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 565655003423 NAD(P) binding site [chemical binding]; other site 565655003424 homodimer interface [polypeptide binding]; other site 565655003425 substrate binding site [chemical binding]; other site 565655003426 active site 565655003427 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 565655003428 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 565655003429 putative trimer interface [polypeptide binding]; other site 565655003430 putative CoA binding site [chemical binding]; other site 565655003431 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 565655003432 aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181 565655003433 inhibitor-cofactor binding pocket; inhibition site 565655003434 pyridoxal 5'-phosphate binding site [chemical binding]; other site 565655003435 catalytic residue [active] 565655003436 Bacterial sugar transferase; Region: Bac_transf; pfam02397 565655003437 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 565655003438 putative ADP-binding pocket [chemical binding]; other site 565655003439 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 565655003440 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 565655003441 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 565655003442 trimer interface [polypeptide binding]; other site 565655003443 active site 565655003444 substrate binding site [chemical binding]; other site 565655003445 CoA binding site [chemical binding]; other site 565655003446 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 565655003447 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 565655003448 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 565655003449 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 565655003450 putative ADP-binding pocket [chemical binding]; other site 565655003451 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 565655003452 TupA-like ATPgrasp; Region: ATPgrasp_TupA; pfam14305 565655003453 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 565655003454 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 565655003455 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 565655003456 putative NAD(P) binding site [chemical binding]; other site 565655003457 active site 565655003458 putative substrate binding site [chemical binding]; other site 565655003459 UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057 565655003460 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 565655003461 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 565655003462 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 565655003463 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 565655003464 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 565655003465 non-specific DNA binding site [nucleotide binding]; other site 565655003466 salt bridge; other site 565655003467 sequence-specific DNA binding site [nucleotide binding]; other site 565655003468 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 565655003469 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 565655003470 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 565655003471 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 565655003472 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 565655003473 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 565655003474 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 565655003475 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 565655003476 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 565655003477 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 565655003478 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 565655003479 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 565655003480 CAAX protease self-immunity; Region: Abi; pfam02517 565655003481 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 565655003482 Catalytic NodB homology domain of Clostridium thermocellum acetylxylan esterase and its bacterial homologs; Region: CE4_CtAXE_like; cd10954 565655003483 NodB motif; other site 565655003484 active site 565655003485 catalytic site [active] 565655003486 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 565655003487 non-specific DNA binding site [nucleotide binding]; other site 565655003488 salt bridge; other site 565655003489 sequence-specific DNA binding site [nucleotide binding]; other site 565655003490 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 565655003491 ribonuclease E; Reviewed; Region: rne; PRK10811 565655003492 WxL domain surface cell wall-binding; Region: WxL; pfam13731 565655003493 WxL domain surface cell wall-binding; Region: WxL; pfam13731 565655003494 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 565655003495 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 565655003496 LytTr DNA-binding domain; Region: LytTR; cl04498 565655003497 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 565655003498 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 565655003499 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 565655003500 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 565655003501 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 565655003502 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 565655003503 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 565655003504 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 565655003505 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 565655003506 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 565655003507 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 565655003508 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 565655003509 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 565655003510 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 565655003511 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 565655003512 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 565655003513 Soluble P-type ATPase [General function prediction only]; Region: COG4087 565655003514 K+-transporting ATPase, c chain; Region: KdpC; cl00944 565655003515 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 565655003516 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 565655003517 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 565655003518 Ligand Binding Site [chemical binding]; other site 565655003519 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 565655003520 GAF domain; Region: GAF_3; pfam13492 565655003521 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 565655003522 dimer interface [polypeptide binding]; other site 565655003523 phosphorylation site [posttranslational modification] 565655003524 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 565655003525 ATP binding site [chemical binding]; other site 565655003526 Mg2+ binding site [ion binding]; other site 565655003527 G-X-G motif; other site 565655003528 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 565655003529 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 565655003530 active site 565655003531 phosphorylation site [posttranslational modification] 565655003532 intermolecular recognition site; other site 565655003533 dimerization interface [polypeptide binding]; other site 565655003534 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 565655003535 DNA binding site [nucleotide binding] 565655003536 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 565655003537 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 565655003538 Coenzyme A binding pocket [chemical binding]; other site 565655003539 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 565655003540 Kinesin motor; Region: Kinesin-relat_1; pfam12711 565655003541 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 565655003542 Peptidase family M23; Region: Peptidase_M23; pfam01551 565655003543 Uncharacterized conserved protein [Function unknown]; Region: COG5646 565655003544 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 565655003545 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 565655003546 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 565655003547 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 565655003548 DNA-binding site [nucleotide binding]; DNA binding site 565655003549 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 565655003550 phosphodiesterase; Provisional; Region: PRK12704 565655003551 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 565655003552 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 565655003553 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 565655003554 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 565655003555 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 565655003556 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 565655003557 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 565655003558 Walker A motif; other site 565655003559 ATP binding site [chemical binding]; other site 565655003560 Walker B motif; other site 565655003561 pilus retraction protein PilT; Region: pilT_fam; TIGR01420 565655003562 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 565655003563 Walker A motif; other site 565655003564 ATP binding site [chemical binding]; other site 565655003565 Walker B motif; other site 565655003566 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 565655003567 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 565655003568 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 565655003569 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 565655003570 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 565655003571 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 565655003572 Competence protein A; Region: Competence_A; pfam11104 565655003573 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 565655003574 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 565655003575 S-adenosylmethionine binding site [chemical binding]; other site 565655003576 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 565655003577 FtsX-like permease family; Region: FtsX; pfam02687 565655003578 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 565655003579 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 565655003580 Walker A/P-loop; other site 565655003581 ATP binding site [chemical binding]; other site 565655003582 Q-loop/lid; other site 565655003583 ABC transporter signature motif; other site 565655003584 Walker B; other site 565655003585 D-loop; other site 565655003586 H-loop/switch region; other site 565655003587 Protein of unknown function (DUF1093); Region: DUF1093; cl02185 565655003588 Protein of unknown function (DUF1576); Region: DUF1576; pfam07613 565655003589 Protein of unknown function (DUF1576); Region: DUF1576; pfam07613 565655003590 The substrate binding component of an ABC-type lactococcal OppA-like transport system contains; Region: PBP2_Lactococcal_OppA_like; cd08510 565655003591 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 565655003592 peptide binding site [polypeptide binding]; other site 565655003593 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 565655003594 non-specific DNA binding site [nucleotide binding]; other site 565655003595 salt bridge; other site 565655003596 sequence-specific DNA binding site [nucleotide binding]; other site 565655003597 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 565655003598 transcriptional antiterminator BglG; Provisional; Region: PRK09772 565655003599 CAT RNA binding domain; Region: CAT_RBD; smart01061 565655003600 PRD domain; Region: PRD; pfam00874 565655003601 PRD domain; Region: PRD; pfam00874 565655003602 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 565655003603 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 565655003604 active site turn [active] 565655003605 phosphorylation site [posttranslational modification] 565655003606 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 565655003607 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 565655003608 HPr interaction site; other site 565655003609 glycerol kinase (GK) interaction site [polypeptide binding]; other site 565655003610 active site 565655003611 phosphorylation site [posttranslational modification] 565655003612 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 565655003613 beta-galactosidase; Region: BGL; TIGR03356 565655003614 oxidoreductase; Provisional; Region: PRK07985 565655003615 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 565655003616 NAD binding site [chemical binding]; other site 565655003617 metal binding site [ion binding]; metal-binding site 565655003618 active site 565655003619 Mga helix-turn-helix domain; Region: Mga; pfam05043 565655003620 WxL domain surface cell wall-binding; Region: WxL; pfam13731 565655003621 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 565655003622 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 565655003623 legume lectins; Region: lectin_L-type; cd01951 565655003624 homotetramer interaction site [polypeptide binding]; other site 565655003625 carbohydrate binding site [chemical binding]; other site 565655003626 metal binding site [ion binding]; metal-binding site 565655003627 Penicillinase repressor; Region: Pencillinase_R; cl17580 565655003628 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 565655003629 MarR family; Region: MarR; pfam01047 565655003630 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 565655003631 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 565655003632 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 565655003633 Predicted integral membrane protein [Function unknown]; Region: COG0392 565655003634 Uncharacterized conserved protein [Function unknown]; Region: COG2898 565655003635 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 565655003636 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 565655003637 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 565655003638 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 565655003639 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 565655003640 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 565655003641 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 565655003642 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 565655003643 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 565655003644 Coenzyme A binding pocket [chemical binding]; other site 565655003645 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 565655003646 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 565655003647 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 565655003648 putative active site [active] 565655003649 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 565655003650 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 565655003651 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 565655003652 putative active site [active] 565655003653 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 565655003654 beta-galactosidase; Region: BGL; TIGR03356 565655003655 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 565655003656 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 565655003657 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 565655003658 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 565655003659 Uncharacterized conserved protein [Function unknown]; Region: COG3589 565655003660 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 565655003661 probable amidohydrolase EF_0837/AHA_3915; Region: EF_0837; TIGR03583 565655003662 Metallo-dependent hydrolases, subgroup B is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_B; cd01307 565655003663 active site 565655003664 uncharacterized pyridoxal phosphate-dependent enzyme; Region: selA_rel; TIGR01437 565655003665 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 565655003666 catalytic residue [active] 565655003667 conserved hypothetical protein EF_0839/AHA_3917; Region: EF_0839; TIGR03581 565655003668 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 565655003669 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 565655003670 substrate binding site [chemical binding]; other site 565655003671 ATP binding site [chemical binding]; other site 565655003672 Protein of unknown function (DUF1211); Region: DUF1211; cl01421 565655003673 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 565655003674 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 565655003675 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 565655003676 active site lid residues [active] 565655003677 substrate binding pocket [chemical binding]; other site 565655003678 catalytic residues [active] 565655003679 substrate-Mg2+ binding site; other site 565655003680 aspartate-rich region 1; other site 565655003681 aspartate-rich region 2; other site 565655003682 phytoene desaturase; Region: crtI_fam; TIGR02734 565655003683 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 565655003684 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 565655003685 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 565655003686 Walker A/P-loop; other site 565655003687 ATP binding site [chemical binding]; other site 565655003688 Q-loop/lid; other site 565655003689 ABC transporter signature motif; other site 565655003690 Walker B; other site 565655003691 D-loop; other site 565655003692 H-loop/switch region; other site 565655003693 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 565655003694 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 565655003695 FtsX-like permease family; Region: FtsX; pfam02687 565655003696 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 565655003697 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 565655003698 N-acetylneuraminate lyase; Region: nanA; TIGR00683 565655003699 inhibitor site; inhibition site 565655003700 active site 565655003701 dimer interface [polypeptide binding]; other site 565655003702 catalytic residue [active] 565655003703 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 565655003704 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 565655003705 active site turn [active] 565655003706 phosphorylation site [posttranslational modification] 565655003707 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 565655003708 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 565655003709 HPr interaction site; other site 565655003710 glycerol kinase (GK) interaction site [polypeptide binding]; other site 565655003711 active site 565655003712 phosphorylation site [posttranslational modification] 565655003713 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 565655003714 beta-galactosidase; Region: BGL; TIGR03356 565655003715 transcriptional antiterminator BglG; Provisional; Region: PRK09772 565655003716 CAT RNA binding domain; Region: CAT_RBD; smart01061 565655003717 PRD domain; Region: PRD; pfam00874 565655003718 PRD domain; Region: PRD; pfam00874 565655003719 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 565655003720 nucleotide binding site/active site [active] 565655003721 HIT family signature motif; other site 565655003722 catalytic residue [active] 565655003723 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 565655003724 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 565655003725 active site 565655003726 catalytic tetrad [active] 565655003727 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 565655003728 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 565655003729 DNA binding residues [nucleotide binding] 565655003730 putative dimer interface [polypeptide binding]; other site 565655003731 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 565655003732 NADH(P)-binding; Region: NAD_binding_10; pfam13460 565655003733 NAD(P) binding site [chemical binding]; other site 565655003734 Uncharacterized conserved protein [Function unknown]; Region: COG1284 565655003735 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 565655003736 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 565655003737 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 565655003738 Walker A/P-loop; other site 565655003739 ATP binding site [chemical binding]; other site 565655003740 Q-loop/lid; other site 565655003741 ABC transporter signature motif; other site 565655003742 Walker B; other site 565655003743 D-loop; other site 565655003744 H-loop/switch region; other site 565655003745 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 565655003746 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 565655003747 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 565655003748 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 565655003749 non-specific DNA binding site [nucleotide binding]; other site 565655003750 salt bridge; other site 565655003751 sequence-specific DNA binding site [nucleotide binding]; other site 565655003752 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 565655003753 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 565655003754 homotrimer interaction site [polypeptide binding]; other site 565655003755 putative active site [active] 565655003756 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 565655003757 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 565655003758 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 565655003759 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 565655003760 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 565655003761 Soluble P-type ATPase [General function prediction only]; Region: COG4087 565655003762 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 565655003763 Mga helix-turn-helix domain; Region: Mga; pfam05043 565655003764 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 565655003765 anthranilate synthase component I; Provisional; Region: PRK13570 565655003766 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 565655003767 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 565655003768 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 565655003769 Glutamine amidotransferase class-I; Region: GATase; pfam00117 565655003770 glutamine binding [chemical binding]; other site 565655003771 catalytic triad [active] 565655003772 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 565655003773 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 565655003774 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 565655003775 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 565655003776 active site 565655003777 ribulose/triose binding site [chemical binding]; other site 565655003778 phosphate binding site [ion binding]; other site 565655003779 substrate (anthranilate) binding pocket [chemical binding]; other site 565655003780 product (indole) binding pocket [chemical binding]; other site 565655003781 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 565655003782 active site 565655003783 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 565655003784 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 565655003785 pyridoxal 5'-phosphate binding site [chemical binding]; other site 565655003786 catalytic residue [active] 565655003787 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 565655003788 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 565655003789 substrate binding site [chemical binding]; other site 565655003790 active site 565655003791 catalytic residues [active] 565655003792 heterodimer interface [polypeptide binding]; other site 565655003793 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 565655003794 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 565655003795 S-adenosylmethionine binding site [chemical binding]; other site 565655003796 2-isopropylmalate synthase; Validated; Region: PRK00915 565655003797 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 565655003798 active site 565655003799 catalytic residues [active] 565655003800 metal binding site [ion binding]; metal-binding site 565655003801 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212 565655003802 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 565655003803 tartrate dehydrogenase; Region: TTC; TIGR02089 565655003804 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 565655003805 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 565655003806 substrate binding site [chemical binding]; other site 565655003807 ligand binding site [chemical binding]; other site 565655003808 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 565655003809 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 565655003810 substrate binding site [chemical binding]; other site 565655003811 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 565655003812 active site 565655003813 Fe-S cluster binding site [ion binding]; other site 565655003814 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 565655003815 Protein of unknown function (DUF464); Region: DUF464; pfam04327 565655003816 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 565655003817 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 565655003818 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 565655003819 Coenzyme A binding pocket [chemical binding]; other site 565655003820 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 565655003821 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 565655003822 substrate binding pocket [chemical binding]; other site 565655003823 membrane-bound complex binding site; other site 565655003824 hinge residues; other site 565655003825 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 565655003826 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 565655003827 Walker A/P-loop; other site 565655003828 ATP binding site [chemical binding]; other site 565655003829 Q-loop/lid; other site 565655003830 ABC transporter signature motif; other site 565655003831 Walker B; other site 565655003832 D-loop; other site 565655003833 H-loop/switch region; other site 565655003834 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 565655003835 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 565655003836 ABC-ATPase subunit interface; other site 565655003837 putative PBP binding loops; other site 565655003838 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 565655003839 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 565655003840 dimer interface [polypeptide binding]; other site 565655003841 conserved gate region; other site 565655003842 putative PBP binding loops; other site 565655003843 ABC-ATPase subunit interface; other site 565655003844 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 565655003845 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 565655003846 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 565655003847 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 565655003848 Coenzyme A binding pocket [chemical binding]; other site 565655003849 Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775 565655003850 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 565655003851 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 565655003852 Walker A motif; other site 565655003853 ATP binding site [chemical binding]; other site 565655003854 Walker B motif; other site 565655003855 arginine finger; other site 565655003856 Transcriptional antiterminator [Transcription]; Region: COG3933 565655003857 PRD domain; Region: PRD; pfam00874 565655003858 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 565655003859 active pocket/dimerization site; other site 565655003860 active site 565655003861 phosphorylation site [posttranslational modification] 565655003862 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 565655003863 active site 565655003864 phosphorylation site [posttranslational modification] 565655003865 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 565655003866 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 565655003867 active pocket/dimerization site; other site 565655003868 active site 565655003869 phosphorylation site [posttranslational modification] 565655003870 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 565655003871 active site 565655003872 phosphorylation site [posttranslational modification] 565655003873 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 565655003874 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 565655003875 Domain of unknown function (DUF956); Region: DUF956; pfam06115 565655003876 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 565655003877 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 565655003878 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 565655003879 active site 565655003880 Asp23 family; Region: Asp23; pfam03780 565655003881 transcription antitermination factor NusB; Region: nusB; TIGR01951 565655003882 putative RNA binding site [nucleotide binding]; other site 565655003883 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14179 565655003884 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 565655003885 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 565655003886 homodimer interface [polypeptide binding]; other site 565655003887 NADP binding site [chemical binding]; other site 565655003888 substrate binding site [chemical binding]; other site 565655003889 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 565655003890 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 565655003891 generic binding surface II; other site 565655003892 generic binding surface I; other site 565655003893 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 565655003894 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 565655003895 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 565655003896 substrate binding pocket [chemical binding]; other site 565655003897 chain length determination region; other site 565655003898 substrate-Mg2+ binding site; other site 565655003899 catalytic residues [active] 565655003900 aspartate-rich region 1; other site 565655003901 active site lid residues [active] 565655003902 aspartate-rich region 2; other site 565655003903 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 565655003904 S4 RNA-binding domain; Region: S4; smart00363 565655003905 RNA binding surface [nucleotide binding]; other site 565655003906 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 565655003907 Arginine repressor [Transcription]; Region: ArgR; COG1438 565655003908 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 565655003909 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 565655003910 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 565655003911 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 565655003912 Walker A/P-loop; other site 565655003913 ATP binding site [chemical binding]; other site 565655003914 Q-loop/lid; other site 565655003915 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 565655003916 Q-loop/lid; other site 565655003917 ABC transporter signature motif; other site 565655003918 Walker B; other site 565655003919 D-loop; other site 565655003920 H-loop/switch region; other site 565655003921 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 565655003922 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 565655003923 phosphate binding protein; Region: ptsS_2; TIGR02136 565655003924 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 565655003925 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 565655003926 dimer interface [polypeptide binding]; other site 565655003927 conserved gate region; other site 565655003928 putative PBP binding loops; other site 565655003929 ABC-ATPase subunit interface; other site 565655003930 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 565655003931 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 565655003932 dimer interface [polypeptide binding]; other site 565655003933 conserved gate region; other site 565655003934 putative PBP binding loops; other site 565655003935 ABC-ATPase subunit interface; other site 565655003936 phosphate transporter ATP-binding protein; Provisional; Region: PRK14237 565655003937 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 565655003938 Walker A/P-loop; other site 565655003939 ATP binding site [chemical binding]; other site 565655003940 Q-loop/lid; other site 565655003941 ABC transporter signature motif; other site 565655003942 Walker B; other site 565655003943 D-loop; other site 565655003944 H-loop/switch region; other site 565655003945 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14255 565655003946 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 565655003947 Walker A/P-loop; other site 565655003948 ATP binding site [chemical binding]; other site 565655003949 Q-loop/lid; other site 565655003950 ABC transporter signature motif; other site 565655003951 Walker B; other site 565655003952 D-loop; other site 565655003953 H-loop/switch region; other site 565655003954 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 565655003955 PhoU domain; Region: PhoU; pfam01895 565655003956 PhoU domain; Region: PhoU; pfam01895 565655003957 Uncharacterized conserved protein [Function unknown]; Region: COG3595 565655003958 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 565655003959 PspC domain; Region: PspC; pfam04024 565655003960 Membrane protein of unknown function; Region: DUF360; pfam04020 565655003961 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_1; cd09606 565655003962 oligoendopeptidase, M3 family; Region: M3_not_pepF; TIGR02289 565655003963 active site 565655003964 Zn binding site [ion binding]; other site 565655003965 HPr kinase/phosphorylase; Provisional; Region: PRK05428 565655003966 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 565655003967 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 565655003968 Hpr binding site; other site 565655003969 active site 565655003970 homohexamer subunit interaction site [polypeptide binding]; other site 565655003971 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 565655003972 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 565655003973 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 565655003974 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 565655003975 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 565655003976 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 565655003977 active site 565655003978 tetramer interface; other site 565655003979 Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768 565655003980 YtxH-like protein; Region: YtxH; pfam12732 565655003981 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 565655003982 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 565655003983 NAD(P) binding site [chemical binding]; other site 565655003984 active site 565655003985 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 565655003986 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 565655003987 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 565655003988 active site 565655003989 catabolite control protein A; Region: ccpA; TIGR01481 565655003990 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 565655003991 DNA binding site [nucleotide binding] 565655003992 domain linker motif; other site 565655003993 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 565655003994 dimerization interface [polypeptide binding]; other site 565655003995 effector binding site; other site 565655003996 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 565655003997 Transglycosylase; Region: Transgly; pfam00912 565655003998 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 565655003999 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 565655004000 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 565655004001 active site 565655004002 HIGH motif; other site 565655004003 dimer interface [polypeptide binding]; other site 565655004004 KMSKS motif; other site 565655004005 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 565655004006 RNA binding surface [nucleotide binding]; other site 565655004007 Membrane transport protein; Region: Mem_trans; cl09117 565655004008 endonuclease IV; Provisional; Region: PRK01060 565655004009 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 565655004010 AP (apurinic/apyrimidinic) site pocket; other site 565655004011 DNA interaction; other site 565655004012 Metal-binding active site; metal-binding site 565655004013 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 565655004014 active site 565655004015 catalytic motif [active] 565655004016 Zn binding site [ion binding]; other site 565655004017 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 565655004018 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 565655004019 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 565655004020 active site 565655004021 phosphorylation site [posttranslational modification] 565655004022 intermolecular recognition site; other site 565655004023 dimerization interface [polypeptide binding]; other site 565655004024 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 565655004025 DNA binding site [nucleotide binding] 565655004026 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 565655004027 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 565655004028 ATP binding site [chemical binding]; other site 565655004029 Mg2+ binding site [ion binding]; other site 565655004030 G-X-G motif; other site 565655004031 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 565655004032 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 565655004033 Walker A/P-loop; other site 565655004034 ATP binding site [chemical binding]; other site 565655004035 Q-loop/lid; other site 565655004036 ABC transporter signature motif; other site 565655004037 Walker B; other site 565655004038 D-loop; other site 565655004039 H-loop/switch region; other site 565655004040 FtsX-like permease family; Region: FtsX; pfam02687 565655004041 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 565655004042 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 565655004043 Mga helix-turn-helix domain; Region: Mga; pfam05043 565655004044 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 565655004045 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 565655004046 Walker A/P-loop; other site 565655004047 ATP binding site [chemical binding]; other site 565655004048 Q-loop/lid; other site 565655004049 ABC transporter signature motif; other site 565655004050 Walker B; other site 565655004051 D-loop; other site 565655004052 H-loop/switch region; other site 565655004053 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 565655004054 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3763 565655004055 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 565655004056 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 565655004057 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 565655004058 Walker A/P-loop; other site 565655004059 ATP binding site [chemical binding]; other site 565655004060 Q-loop/lid; other site 565655004061 ABC transporter signature motif; other site 565655004062 Walker B; other site 565655004063 D-loop; other site 565655004064 H-loop/switch region; other site 565655004065 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 565655004066 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 565655004067 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 565655004068 Walker A/P-loop; other site 565655004069 ATP binding site [chemical binding]; other site 565655004070 Q-loop/lid; other site 565655004071 ABC transporter signature motif; other site 565655004072 Walker B; other site 565655004073 D-loop; other site 565655004074 H-loop/switch region; other site 565655004075 transcriptional antiterminator BglG; Provisional; Region: PRK09772 565655004076 CAT RNA binding domain; Region: CAT_RBD; smart01061 565655004077 PRD domain; Region: PRD; pfam00874 565655004078 PRD domain; Region: PRD; pfam00874 565655004079 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 565655004080 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 565655004081 active site turn [active] 565655004082 phosphorylation site [posttranslational modification] 565655004083 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 565655004084 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 565655004085 HPr interaction site; other site 565655004086 glycerol kinase (GK) interaction site [polypeptide binding]; other site 565655004087 active site 565655004088 phosphorylation site [posttranslational modification] 565655004089 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 565655004090 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 565655004091 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 565655004092 putative active site [active] 565655004093 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 565655004094 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 565655004095 NAD binding site [chemical binding]; other site 565655004096 sugar binding site [chemical binding]; other site 565655004097 divalent metal binding site [ion binding]; other site 565655004098 tetramer (dimer of dimers) interface [polypeptide binding]; other site 565655004099 dimer interface [polypeptide binding]; other site 565655004100 6-phospho-beta-glucosidase; Reviewed; Region: arb; PRK09593 565655004101 beta-galactosidase; Region: BGL; TIGR03356 565655004102 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 565655004103 catalytic residues [active] 565655004104 dimer interface [polypeptide binding]; other site 565655004105 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134 565655004106 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 565655004107 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 565655004108 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 565655004109 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 565655004110 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 565655004111 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 565655004112 active site 565655004113 substrate binding site [chemical binding]; other site 565655004114 metal binding site [ion binding]; metal-binding site 565655004115 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 565655004116 dimerization interface [polypeptide binding]; other site 565655004117 putative DNA binding site [nucleotide binding]; other site 565655004118 putative Zn2+ binding site [ion binding]; other site 565655004119 homoserine dehydrogenase; Provisional; Region: PRK06349 565655004120 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 565655004121 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 565655004122 threonine synthase; Reviewed; Region: PRK06721 565655004123 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 565655004124 homodimer interface [polypeptide binding]; other site 565655004125 pyridoxal 5'-phosphate binding site [chemical binding]; other site 565655004126 catalytic residue [active] 565655004127 homoserine kinase; Provisional; Region: PRK01212 565655004128 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 565655004129 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 565655004130 Kinase/pyrophosphorylase; Region: Kinase-PPPase; pfam03618 565655004131 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 565655004132 metal binding site 2 [ion binding]; metal-binding site 565655004133 putative DNA binding helix; other site 565655004134 metal binding site 1 [ion binding]; metal-binding site 565655004135 dimer interface [polypeptide binding]; other site 565655004136 structural Zn2+ binding site [ion binding]; other site 565655004137 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 565655004138 Yqey-like protein; Region: YqeY; pfam09424 565655004139 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 565655004140 KH domain; Region: KH_1; pfam00013 565655004141 PhoH-like protein; Region: PhoH; pfam02562 565655004142 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 565655004143 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 565655004144 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 565655004145 Zn2+ binding site [ion binding]; other site 565655004146 Mg2+ binding site [ion binding]; other site 565655004147 metal-binding heat shock protein; Provisional; Region: PRK00016 565655004148 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219 565655004149 GTPase Era; Reviewed; Region: era; PRK00089 565655004150 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 565655004151 G1 box; other site 565655004152 GTP/Mg2+ binding site [chemical binding]; other site 565655004153 Switch I region; other site 565655004154 G2 box; other site 565655004155 Switch II region; other site 565655004156 G3 box; other site 565655004157 G4 box; other site 565655004158 G5 box; other site 565655004159 KH domain; Region: KH_2; pfam07650 565655004160 Recombination protein O N terminal; Region: RecO_N; pfam11967 565655004161 DNA repair protein RecO; Region: reco; TIGR00613 565655004162 Recombination protein O C terminal; Region: RecO_C; pfam02565 565655004163 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 565655004164 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 565655004165 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 565655004166 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 565655004167 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 565655004168 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 565655004169 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 565655004170 Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301 565655004171 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 565655004172 dimer interface [polypeptide binding]; other site 565655004173 motif 1; other site 565655004174 active site 565655004175 motif 2; other site 565655004176 motif 3; other site 565655004177 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 565655004178 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 565655004179 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 565655004180 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 565655004181 active site 565655004182 phosphorylation site [posttranslational modification] 565655004183 intermolecular recognition site; other site 565655004184 dimerization interface [polypeptide binding]; other site 565655004185 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 565655004186 DNA binding site [nucleotide binding] 565655004187 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 565655004188 dimer interface [polypeptide binding]; other site 565655004189 phosphorylation site [posttranslational modification] 565655004190 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 565655004191 ATP binding site [chemical binding]; other site 565655004192 Mg2+ binding site [ion binding]; other site 565655004193 G-X-G motif; other site 565655004194 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 565655004195 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 565655004196 HlyD family secretion protein; Region: HlyD_3; pfam13437 565655004197 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 565655004198 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 565655004199 Walker A/P-loop; other site 565655004200 ATP binding site [chemical binding]; other site 565655004201 Q-loop/lid; other site 565655004202 ABC transporter signature motif; other site 565655004203 Walker B; other site 565655004204 D-loop; other site 565655004205 H-loop/switch region; other site 565655004206 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 565655004207 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 565655004208 FtsX-like permease family; Region: FtsX; pfam02687 565655004209 TRAM domain; Region: TRAM; pfam01938 565655004210 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 565655004211 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 565655004212 S-adenosylmethionine binding site [chemical binding]; other site 565655004213 RecX family; Region: RecX; cl00936 565655004214 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 565655004215 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 565655004216 minor groove reading motif; other site 565655004217 helix-hairpin-helix signature motif; other site 565655004218 substrate binding pocket [chemical binding]; other site 565655004219 active site 565655004220 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 565655004221 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 565655004222 DNA binding and oxoG recognition site [nucleotide binding] 565655004223 hypothetical protein; Provisional; Region: PRK13662 565655004224 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 565655004225 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 565655004226 active site 565655004227 metal binding site [ion binding]; metal-binding site 565655004228 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444 565655004229 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 565655004230 Coenzyme A binding pocket [chemical binding]; other site 565655004231 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 565655004232 Domain of unknown function DUF20; Region: UPF0118; pfam01594 565655004233 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 565655004234 Domain of unknown function DUF21; Region: DUF21; pfam01595 565655004235 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 565655004236 Transporter associated domain; Region: CorC_HlyC; pfam03471 565655004237 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 565655004238 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 565655004239 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 565655004240 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 565655004241 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 565655004242 Walker A/P-loop; other site 565655004243 ATP binding site [chemical binding]; other site 565655004244 Q-loop/lid; other site 565655004245 ABC transporter signature motif; other site 565655004246 Walker B; other site 565655004247 D-loop; other site 565655004248 H-loop/switch region; other site 565655004249 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 565655004250 dimer interface [polypeptide binding]; other site 565655004251 conserved gate region; other site 565655004252 putative PBP binding loops; other site 565655004253 ABC-ATPase subunit interface; other site 565655004254 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 565655004255 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 565655004256 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 565655004257 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 565655004258 G1 box; other site 565655004259 putative GEF interaction site [polypeptide binding]; other site 565655004260 GTP/Mg2+ binding site [chemical binding]; other site 565655004261 Switch I region; other site 565655004262 G2 box; other site 565655004263 G3 box; other site 565655004264 Switch II region; other site 565655004265 G4 box; other site 565655004266 G5 box; other site 565655004267 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 565655004268 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 565655004269 Helix-turn-helix domain; Region: HTH_28; pfam13518 565655004270 putative transposase OrfB; Reviewed; Region: PHA02517 565655004271 HTH-like domain; Region: HTH_21; pfam13276 565655004272 Integrase core domain; Region: rve; pfam00665 565655004273 Integrase core domain; Region: rve_2; pfam13333 565655004274 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 565655004275 Domain of unknown function (DUF1827); Region: DUF1827; pfam08860 565655004276 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 565655004277 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 565655004278 Walker A motif; other site 565655004279 ATP binding site [chemical binding]; other site 565655004280 Walker B motif; other site 565655004281 arginine finger; other site 565655004282 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 565655004283 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 565655004284 Walker A motif; other site 565655004285 ATP binding site [chemical binding]; other site 565655004286 Walker B motif; other site 565655004287 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 565655004288 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 565655004289 dimerization domain swap beta strand [polypeptide binding]; other site 565655004290 regulatory protein interface [polypeptide binding]; other site 565655004291 active site 565655004292 regulatory phosphorylation site [posttranslational modification]; other site 565655004293 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 565655004294 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 565655004295 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 565655004296 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 565655004297 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 565655004298 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 565655004299 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 565655004300 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 565655004301 putative ADP-binding pocket [chemical binding]; other site 565655004302 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 565655004303 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 565655004304 Protein of unknown function (DUF1797); Region: DUF1797; pfam08796 565655004305 Nuclease subunit of the excinuclease complex [DNA replication, recombination, and repair]; Region: UvrC; COG0322 565655004306 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 565655004307 GIY-YIG motif/motif A; other site 565655004308 active site 565655004309 catalytic site [active] 565655004310 putative DNA binding site [nucleotide binding]; other site 565655004311 metal binding site [ion binding]; metal-binding site 565655004312 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 565655004313 MarR family; Region: MarR_2; pfam12802 565655004314 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 565655004315 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 565655004316 dimer interface [polypeptide binding]; other site 565655004317 active site 565655004318 CoA binding pocket [chemical binding]; other site 565655004319 acyl carrier protein; Provisional; Region: acpP; PRK00982 565655004320 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 565655004321 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 565655004322 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 565655004323 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 565655004324 NAD(P) binding site [chemical binding]; other site 565655004325 homotetramer interface [polypeptide binding]; other site 565655004326 homodimer interface [polypeptide binding]; other site 565655004327 active site 565655004328 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 565655004329 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 565655004330 dimer interface [polypeptide binding]; other site 565655004331 active site 565655004332 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 565655004333 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 565655004334 carboxyltransferase (CT) interaction site; other site 565655004335 biotinylation site [posttranslational modification]; other site 565655004336 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 565655004337 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 565655004338 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 565655004339 ATP-grasp domain; Region: ATP-grasp_4; cl17255 565655004340 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 565655004341 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 565655004342 DNA directed RNA polymerase, 7 kDa subunit; Region: DNA_RNApol_7kD; cl00874 565655004343 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 565655004344 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 565655004345 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 565655004346 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 565655004347 substrate binding pocket [chemical binding]; other site 565655004348 membrane-bound complex binding site; other site 565655004349 hinge residues; other site 565655004350 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 565655004351 dimer interface [polypeptide binding]; other site 565655004352 conserved gate region; other site 565655004353 putative PBP binding loops; other site 565655004354 ABC-ATPase subunit interface; other site 565655004355 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 565655004356 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 565655004357 Walker A/P-loop; other site 565655004358 ATP binding site [chemical binding]; other site 565655004359 Q-loop/lid; other site 565655004360 ABC transporter signature motif; other site 565655004361 Walker B; other site 565655004362 D-loop; other site 565655004363 H-loop/switch region; other site 565655004364 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 565655004365 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 565655004366 active site 565655004367 motif I; other site 565655004368 motif II; other site 565655004369 GTPase YqeH; Provisional; Region: PRK13796 565655004370 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 565655004371 GTP/Mg2+ binding site [chemical binding]; other site 565655004372 G4 box; other site 565655004373 G5 box; other site 565655004374 G1 box; other site 565655004375 Switch I region; other site 565655004376 G2 box; other site 565655004377 G3 box; other site 565655004378 Switch II region; other site 565655004379 Escherichia coli YhbY is associated with pre-50S ribosomal subunits, which implies a function in ribosome assembly; Region: CRS1_YhbY; smart01103 565655004380 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 565655004381 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 565655004382 active site 565655004383 (T/H)XGH motif; other site 565655004384 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 565655004385 Zn2+ binding site [ion binding]; other site 565655004386 Mg2+ binding site [ion binding]; other site 565655004387 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 565655004388 Methyltransferase domain; Region: Methyltransf_23; pfam13489 565655004389 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 565655004390 S-adenosylmethionine binding site [chemical binding]; other site 565655004391 hypothetical protein; Provisional; Region: PRK13670 565655004392 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673 565655004393 hypothetical protein; Provisional; Region: PRK12378 565655004394 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 565655004395 Part of AAA domain; Region: AAA_19; pfam13245 565655004396 Family description; Region: UvrD_C_2; pfam13538 565655004397 Streptomycin adenylyltransferase; Region: Adenyl_transf; pfam04439 565655004398 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 565655004399 4-oxalocrotonate tautomerase; Provisional; Region: PRK02220 565655004400 active site 1 [active] 565655004401 dimer interface [polypeptide binding]; other site 565655004402 hexamer interface [polypeptide binding]; other site 565655004403 active site 2 [active] 565655004404 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 565655004405 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 565655004406 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 565655004407 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 565655004408 active site 565655004409 dimer interface [polypeptide binding]; other site 565655004410 motif 1; other site 565655004411 motif 2; other site 565655004412 motif 3; other site 565655004413 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 565655004414 anticodon binding site; other site 565655004415 Domain of unknown function (DUF4234); Region: DUF4234; pfam14018 565655004416 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 565655004417 ribosome maturation protein RimP; Reviewed; Region: PRK00092 565655004418 Sm and related proteins; Region: Sm_like; cl00259 565655004419 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 565655004420 putative oligomer interface [polypeptide binding]; other site 565655004421 putative RNA binding site [nucleotide binding]; other site 565655004422 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 565655004423 NusA N-terminal domain; Region: NusA_N; pfam08529 565655004424 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 565655004425 RNA binding site [nucleotide binding]; other site 565655004426 homodimer interface [polypeptide binding]; other site 565655004427 NusA-like KH domain; Region: KH_5; pfam13184 565655004428 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 565655004429 G-X-X-G motif; other site 565655004430 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 565655004431 putative RNA binding cleft [nucleotide binding]; other site 565655004432 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 565655004433 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 565655004434 translation initiation factor IF-2; Region: IF-2; TIGR00487 565655004435 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 565655004436 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 565655004437 G1 box; other site 565655004438 putative GEF interaction site [polypeptide binding]; other site 565655004439 GTP/Mg2+ binding site [chemical binding]; other site 565655004440 Switch I region; other site 565655004441 G2 box; other site 565655004442 G3 box; other site 565655004443 Switch II region; other site 565655004444 G4 box; other site 565655004445 G5 box; other site 565655004446 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 565655004447 Translation-initiation factor 2; Region: IF-2; pfam11987 565655004448 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 565655004449 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 565655004450 HTH-like domain; Region: HTH_21; pfam13276 565655004451 Integrase core domain; Region: rve; pfam00665 565655004452 Integrase core domain; Region: rve_2; pfam13333 565655004453 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 565655004454 Helix-turn-helix domain; Region: HTH_28; pfam13518 565655004455 Helix-turn-helix domain; Region: HTH_28; pfam13518 565655004456 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 565655004457 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 565655004458 active site 565655004459 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01550 565655004460 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 565655004461 RNA binding site [nucleotide binding]; other site 565655004462 active site 565655004463 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 565655004464 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 565655004465 active site 565655004466 Riboflavin kinase; Region: Flavokinase; smart00904 565655004467 Predicted membrane protein [Function unknown]; Region: COG1288; cl17886 565655004468 hypothetical protein; Provisional; Region: PRK11588 565655004469 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 565655004470 isoaspartyl dipeptidase; Provisional; Region: PRK10657 565655004471 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 565655004472 active site 565655004473 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 565655004474 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 565655004475 active site 565655004476 catalytic tetrad [active] 565655004477 thiopurine S-methyltransferase; Reviewed; Region: PRK13255 565655004478 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 565655004479 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 565655004480 FeS/SAM binding site; other site 565655004481 HemN C-terminal domain; Region: HemN_C; pfam06969 565655004482 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 565655004483 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cl17326 565655004484 GrpE; Region: GrpE; pfam01025 565655004485 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 565655004486 dimer interface [polypeptide binding]; other site 565655004487 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 565655004488 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 565655004489 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 565655004490 nucleotide binding site [chemical binding]; other site 565655004491 NEF interaction site [polypeptide binding]; other site 565655004492 SBD interface [polypeptide binding]; other site 565655004493 chaperone protein DnaJ; Provisional; Region: PRK14276 565655004494 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 565655004495 HSP70 interaction site [polypeptide binding]; other site 565655004496 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 565655004497 substrate binding site [polypeptide binding]; other site 565655004498 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 565655004499 Zn binding sites [ion binding]; other site 565655004500 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 565655004501 substrate binding site [polypeptide binding]; other site 565655004502 dimer interface [polypeptide binding]; other site 565655004503 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 565655004504 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 565655004505 dimer interface [polypeptide binding]; other site 565655004506 active site 565655004507 metal binding site [ion binding]; metal-binding site 565655004508 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 565655004509 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 565655004510 dimer interface [polypeptide binding]; other site 565655004511 pyridoxal 5'-phosphate binding site [chemical binding]; other site 565655004512 catalytic residue [active] 565655004513 cystathionine gamma-synthase/cystathionine beta-lyase; Validated; Region: PRK06176 565655004514 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 565655004515 homodimer interface [polypeptide binding]; other site 565655004516 substrate-cofactor binding pocket; other site 565655004517 pyridoxal 5'-phosphate binding site [chemical binding]; other site 565655004518 catalytic residue [active] 565655004519 Methyltransferase domain; Region: Methyltransf_23; pfam13489 565655004520 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 565655004521 S-adenosylmethionine binding site [chemical binding]; other site 565655004522 S-ribosylhomocysteinase; Provisional; Region: PRK02260 565655004523 SmpA / OmlA family; Region: SmpA_OmlA; cl17115 565655004524 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 565655004525 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 565655004526 Walker A/P-loop; other site 565655004527 ATP binding site [chemical binding]; other site 565655004528 Q-loop/lid; other site 565655004529 ABC transporter signature motif; other site 565655004530 Walker B; other site 565655004531 D-loop; other site 565655004532 H-loop/switch region; other site 565655004533 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 565655004534 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 565655004535 substrate binding pocket [chemical binding]; other site 565655004536 membrane-bound complex binding site; other site 565655004537 hinge residues; other site 565655004538 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 565655004539 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 565655004540 substrate binding pocket [chemical binding]; other site 565655004541 membrane-bound complex binding site; other site 565655004542 hinge residues; other site 565655004543 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 565655004544 dimer interface [polypeptide binding]; other site 565655004545 conserved gate region; other site 565655004546 ABC-ATPase subunit interface; other site 565655004547 excinuclease ABC subunit B; Provisional; Region: PRK05298 565655004548 Myosin and Kinesin motor domain. These ATPases belong to the P-loop NTPase family and provide the driving force in myosin and kinesin mediated processes; Region: Motor_domain; cl00286 565655004549 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 565655004550 ATP-binding site [chemical binding]; other site 565655004551 ATP binding site [chemical binding]; other site 565655004552 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 565655004553 nucleotide binding region [chemical binding]; other site 565655004554 ATP-binding site [chemical binding]; other site 565655004555 Ultra-violet resistance protein B; Region: UvrB; pfam12344 565655004556 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 565655004557 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 565655004558 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 565655004559 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 565655004560 Predicted ATP-grasp enzyme [General function prediction only]; Region: COG3919 565655004561 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 565655004562 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 565655004563 aspartate racemase; Region: asp_race; TIGR00035 565655004564 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 565655004565 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 565655004566 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 565655004567 phosphate binding site [ion binding]; other site 565655004568 putative substrate binding pocket [chemical binding]; other site 565655004569 dimer interface [polypeptide binding]; other site 565655004570 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 565655004571 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 565655004572 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 565655004573 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 565655004574 catalytic residues [active] 565655004575 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 565655004576 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 565655004577 dimer interface [polypeptide binding]; other site 565655004578 PYR/PP interface [polypeptide binding]; other site 565655004579 TPP binding site [chemical binding]; other site 565655004580 substrate binding site [chemical binding]; other site 565655004581 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 565655004582 Domain of unknown function; Region: EKR; pfam10371 565655004583 4Fe-4S binding domain; Region: Fer4_6; pfam12837 565655004584 4Fe-4S binding domain; Region: Fer4; pfam00037 565655004585 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 565655004586 TPP-binding site [chemical binding]; other site 565655004587 dimer interface [polypeptide binding]; other site 565655004588 Uncharacterized conserved protein [Function unknown]; Region: COG1624 565655004589 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 565655004590 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 565655004591 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 565655004592 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 565655004593 active site 565655004594 substrate binding site [chemical binding]; other site 565655004595 metal binding site [ion binding]; metal-binding site 565655004596 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 565655004597 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 565655004598 glutaminase active site [active] 565655004599 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 565655004600 dimer interface [polypeptide binding]; other site 565655004601 active site 565655004602 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 565655004603 dimer interface [polypeptide binding]; other site 565655004604 active site 565655004605 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 565655004606 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 565655004607 tandem repeat interface [polypeptide binding]; other site 565655004608 oligomer interface [polypeptide binding]; other site 565655004609 active site residues [active] 565655004610 RDD family; Region: RDD; pfam06271 565655004611 trigger factor; Provisional; Region: tig; PRK01490 565655004612 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 565655004613 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 565655004614 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 565655004615 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 565655004616 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 565655004617 Walker A motif; other site 565655004618 ATP binding site [chemical binding]; other site 565655004619 Walker B motif; other site 565655004620 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 565655004621 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 565655004622 G1 box; other site 565655004623 GTP/Mg2+ binding site [chemical binding]; other site 565655004624 Switch I region; other site 565655004625 G2 box; other site 565655004626 G3 box; other site 565655004627 Switch II region; other site 565655004628 G4 box; other site 565655004629 G5 box; other site 565655004630 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 565655004631 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 565655004632 non-specific DNA binding site [nucleotide binding]; other site 565655004633 salt bridge; other site 565655004634 sequence-specific DNA binding site [nucleotide binding]; other site 565655004635 HTH-like domain; Region: HTH_21; pfam13276 565655004636 Integrase core domain; Region: rve; pfam00665 565655004637 Integrase core domain; Region: rve_2; pfam13333 565655004638 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 565655004639 Helix-turn-helix domain; Region: HTH_28; pfam13518 565655004640 Helix-turn-helix domain; Region: HTH_28; pfam13518 565655004641 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 565655004642 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 565655004643 active site 565655004644 phosphorylation site [posttranslational modification] 565655004645 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 565655004646 active site 565655004647 P-loop; other site 565655004648 phosphorylation site [posttranslational modification] 565655004649 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 565655004650 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 565655004651 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 565655004652 putative substrate binding site [chemical binding]; other site 565655004653 putative ATP binding site [chemical binding]; other site 565655004654 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 565655004655 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 565655004656 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 565655004657 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 565655004658 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 565655004659 active site 565655004660 Na/Ca binding site [ion binding]; other site 565655004661 catalytic site [active] 565655004662 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 565655004663 Part of AAA domain; Region: AAA_19; pfam13245 565655004664 Family description; Region: UvrD_C_2; pfam13538 565655004665 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 565655004666 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 565655004667 nucleotide binding pocket [chemical binding]; other site 565655004668 K-X-D-G motif; other site 565655004669 catalytic site [active] 565655004670 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 565655004671 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 565655004672 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 565655004673 Dimer interface [polypeptide binding]; other site 565655004674 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 565655004675 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 565655004676 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 565655004677 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 565655004678 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 565655004679 GatB domain; Region: GatB_Yqey; smart00845 565655004680 putative lipid kinase; Reviewed; Region: PRK13055 565655004681 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 565655004682 Protein of unknown function (DUF1507); Region: DUF1507; pfam07408 565655004683 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 565655004684 pyruvate carboxylase; Reviewed; Region: PRK12999 565655004685 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 565655004686 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 565655004687 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 565655004688 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 565655004689 active site 565655004690 catalytic residues [active] 565655004691 metal binding site [ion binding]; metal-binding site 565655004692 homodimer binding site [polypeptide binding]; other site 565655004693 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 565655004694 carboxyltransferase (CT) interaction site; other site 565655004695 biotinylation site [posttranslational modification]; other site 565655004696 Protein of unknown function (DUF964); Region: DUF964; pfam06133 565655004697 Uncharacterized protein conserved in bacteria (DUF2129); Region: DUF2129; pfam09902 565655004698 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 565655004699 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 565655004700 S-adenosylmethionine binding site [chemical binding]; other site 565655004701 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 565655004702 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 565655004703 active site 565655004704 (T/H)XGH motif; other site 565655004705 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 565655004706 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 565655004707 protein binding site [polypeptide binding]; other site 565655004708 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 565655004709 Protein of unknown function (DUF1149); Region: DUF1149; cl11551 565655004710 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 565655004711 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 565655004712 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 565655004713 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 565655004714 active site 565655004715 metal binding site [ion binding]; metal-binding site 565655004716 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 565655004717 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 565655004718 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 565655004719 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 565655004720 RNA binding site [nucleotide binding]; other site 565655004721 hypothetical protein; Provisional; Region: PRK04351 565655004722 SprT homologues; Region: SprT; cl01182 565655004723 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 565655004724 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 565655004725 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 565655004726 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 565655004727 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 565655004728 active site 2 [active] 565655004729 active site 1 [active] 565655004730 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 565655004731 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 565655004732 DNA polymerase I; Provisional; Region: PRK05755 565655004733 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 565655004734 active site 565655004735 metal binding site 1 [ion binding]; metal-binding site 565655004736 putative 5' ssDNA interaction site; other site 565655004737 metal binding site 3; metal-binding site 565655004738 metal binding site 2 [ion binding]; metal-binding site 565655004739 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 565655004740 putative DNA binding site [nucleotide binding]; other site 565655004741 putative metal binding site [ion binding]; other site 565655004742 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 565655004743 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 565655004744 active site 565655004745 DNA binding site [nucleotide binding] 565655004746 catalytic site [active] 565655004747 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 565655004748 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 565655004749 DNA binding site [nucleotide binding] 565655004750 catalytic residue [active] 565655004751 H2TH interface [polypeptide binding]; other site 565655004752 putative catalytic residues [active] 565655004753 turnover-facilitating residue; other site 565655004754 intercalation triad [nucleotide binding]; other site 565655004755 8OG recognition residue [nucleotide binding]; other site 565655004756 putative reading head residues; other site 565655004757 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 565655004758 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 565655004759 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 565655004760 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 565655004761 CoA-binding site [chemical binding]; other site 565655004762 ATP-binding [chemical binding]; other site 565655004763 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 565655004764 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 565655004765 Walker A/P-loop; other site 565655004766 ATP binding site [chemical binding]; other site 565655004767 Q-loop/lid; other site 565655004768 ABC transporter signature motif; other site 565655004769 Walker B; other site 565655004770 D-loop; other site 565655004771 H-loop/switch region; other site 565655004772 Fibronectin-binding protein (FBP); Region: FBP; pfam07299 565655004773 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 565655004774 Transcription factor S-II (TFIIS); Region: TFIIS_C; cl02609 565655004775 ATP cone domain; Region: ATP-cone; pfam03477 565655004776 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 565655004777 primosomal protein DnaI; Reviewed; Region: PRK08939 565655004778 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 565655004779 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 565655004780 Walker A motif; other site 565655004781 ATP binding site [chemical binding]; other site 565655004782 Walker B motif; other site 565655004783 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 565655004784 Family of unknown function (DUF633); Region: DUF633; pfam04816 565655004785 Uncharacterized conserved protein [Function unknown]; Region: COG0327 565655004786 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 565655004787 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 565655004788 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 565655004789 Uncharacterized conserved protein [Function unknown]; Region: COG0327 565655004790 peptidase T; Region: peptidase-T; TIGR01882 565655004791 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 565655004792 metal binding site [ion binding]; metal-binding site 565655004793 dimer interface [polypeptide binding]; other site 565655004794 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 565655004795 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 565655004796 Protein of unknown function (DUF1294); Region: DUF1294; pfam06961 565655004797 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 565655004798 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 565655004799 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 565655004800 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 565655004801 ABC transporter; Region: ABC_tran_2; pfam12848 565655004802 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 565655004803 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 565655004804 Clp amino terminal domain; Region: Clp_N; pfam02861 565655004805 Clp amino terminal domain; Region: Clp_N; pfam02861 565655004806 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 565655004807 Walker A motif; other site 565655004808 ATP binding site [chemical binding]; other site 565655004809 Walker B motif; other site 565655004810 arginine finger; other site 565655004811 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 565655004812 Walker A motif; other site 565655004813 ATP binding site [chemical binding]; other site 565655004814 Walker B motif; other site 565655004815 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 565655004816 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 565655004817 dimer interface [polypeptide binding]; other site 565655004818 conserved gate region; other site 565655004819 ABC-ATPase subunit interface; other site 565655004820 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 565655004821 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 565655004822 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 565655004823 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 565655004824 Walker A/P-loop; other site 565655004825 ATP binding site [chemical binding]; other site 565655004826 Q-loop/lid; other site 565655004827 ABC transporter signature motif; other site 565655004828 Walker B; other site 565655004829 D-loop; other site 565655004830 H-loop/switch region; other site 565655004831 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 565655004832 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 565655004833 Catalytic site [active] 565655004834 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 565655004835 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014 565655004836 Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527 565655004837 Sterol carrier protein domain; Region: SCP2_2; pfam13530 565655004838 GTP-binding protein LepA; Provisional; Region: PRK05433 565655004839 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 565655004840 G1 box; other site 565655004841 putative GEF interaction site [polypeptide binding]; other site 565655004842 GTP/Mg2+ binding site [chemical binding]; other site 565655004843 Switch I region; other site 565655004844 G2 box; other site 565655004845 G3 box; other site 565655004846 Switch II region; other site 565655004847 G4 box; other site 565655004848 G5 box; other site 565655004849 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 565655004850 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 565655004851 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 565655004852 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 565655004853 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 565655004854 NADP binding site [chemical binding]; other site 565655004855 dimer interface [polypeptide binding]; other site 565655004856 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 565655004857 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 565655004858 dimerization interface [polypeptide binding]; other site 565655004859 DNA binding residues [nucleotide binding] 565655004860 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 565655004861 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 565655004862 FeS/SAM binding site; other site 565655004863 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 565655004864 glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774 565655004865 Predicted permeases [General function prediction only]; Region: COG0730 565655004866 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 565655004867 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 565655004868 active site 565655004869 NAD binding site [chemical binding]; other site 565655004870 metal binding site [ion binding]; metal-binding site 565655004871 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 565655004872 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 565655004873 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 565655004874 Domain of unknown function (DUF1127); Region: DUF1127; cl02276 565655004875 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 565655004876 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 565655004877 Walker A/P-loop; other site 565655004878 ATP binding site [chemical binding]; other site 565655004879 Q-loop/lid; other site 565655004880 ABC transporter signature motif; other site 565655004881 Walker B; other site 565655004882 D-loop; other site 565655004883 H-loop/switch region; other site 565655004884 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 565655004885 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 565655004886 Coenzyme A binding pocket [chemical binding]; other site 565655004887 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 565655004888 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 565655004889 DNA-binding site [nucleotide binding]; DNA binding site 565655004890 FCD domain; Region: FCD; pfam07729 565655004891 N-terminal, non-catalytic, domain of BphC_JF8, (2,3-dihydroxybiphenyl 1,2-dioxygenase) from Bacillus sp. JF8 and similar proteins; Region: BphC-JF8_N_like; cd09013 565655004892 tetramer interface [polypeptide binding]; other site 565655004893 catechol 2,3 dioxygenase; Region: catechol_2_3; TIGR03211 565655004894 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 565655004895 active site 565655004896 metal binding site [ion binding]; metal-binding site 565655004897 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 565655004898 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 565655004899 hypothetical protein; Validated; Region: PRK06201 565655004900 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 565655004901 homotrimer interaction site [polypeptide binding]; other site 565655004902 putative active site [active] 565655004903 Protein of unknown function (DUF554); Region: DUF554; pfam04474 565655004904 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 565655004905 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 565655004906 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 565655004907 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 565655004908 dimer interface [polypeptide binding]; other site 565655004909 conserved gate region; other site 565655004910 putative PBP binding loops; other site 565655004911 ABC-ATPase subunit interface; other site 565655004912 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 565655004913 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 565655004914 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 565655004915 dimer interface [polypeptide binding]; other site 565655004916 conserved gate region; other site 565655004917 putative PBP binding loops; other site 565655004918 ABC-ATPase subunit interface; other site 565655004919 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 565655004920 Walker A/P-loop; other site 565655004921 ATP binding site [chemical binding]; other site 565655004922 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 565655004923 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 565655004924 Q-loop/lid; other site 565655004925 ABC transporter signature motif; other site 565655004926 Walker B; other site 565655004927 D-loop; other site 565655004928 H-loop/switch region; other site 565655004929 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 565655004930 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 565655004931 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 565655004932 Walker A/P-loop; other site 565655004933 ATP binding site [chemical binding]; other site 565655004934 Q-loop/lid; other site 565655004935 ABC transporter signature motif; other site 565655004936 Walker B; other site 565655004937 D-loop; other site 565655004938 H-loop/switch region; other site 565655004939 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 565655004940 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 565655004941 Transcriptional regulator [Transcription]; Region: LysR; COG0583 565655004942 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 565655004943 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 565655004944 dimerization interface [polypeptide binding]; other site 565655004945 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 565655004946 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 565655004947 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 565655004948 Transcriptional regulator [Transcription]; Region: LysR; COG0583 565655004949 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 565655004950 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 565655004951 dimerization interface [polypeptide binding]; other site 565655004952 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 565655004953 malonate decarboxylase, epsilon subunit; Region: malonate_mdcH; TIGR03131 565655004954 malonate decarboxylase, alpha subunit; Region: mdcA; TIGR01110 565655004955 Coenzyme A transferase; Region: CoA_trans; cl17247 565655004956 malonate decarboxylase acyl carrier protein; Region: malonate_delta; TIGR03130 565655004957 malonate decarboxylase, beta subunit; Region: malonate_beta; TIGR03133 565655004958 malonate decarboxylase, gamma subunit; Region: malonate_gamma; TIGR03134 565655004959 phosphoribosyl-dephospho-CoA transferase; Provisional; Region: PRK01293; cl07913 565655004960 Phosphoribosyl-dephospho-CoA transferase MdcG; Region: MdcG; pfam10620 565655004961 Acyltransferase family; Region: Acyl_transf_3; pfam01757 565655004962 triphosphoribosyl-dephospho-CoA synthase MdcB; Region: malonate_mdcB; TIGR03132 565655004963 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 565655004964 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 565655004965 GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718 565655004966 Coenzyme A binding pocket [chemical binding]; other site 565655004967 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 565655004968 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 565655004969 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 565655004970 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 565655004971 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 565655004972 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 565655004973 putative active site [active] 565655004974 putative oxidoreductase; Provisional; Region: PRK10206 565655004975 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 565655004976 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 565655004977 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 565655004978 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 565655004979 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 565655004980 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 565655004981 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 565655004982 RNA polymerase factor sigma-70; Validated; Region: PRK06811 565655004983 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 565655004984 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 565655004985 AmiS/UreI family transporter; Region: AmiS_UreI; pfam02293 565655004986 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 565655004987 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; pfam13930 565655004988 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 565655004989 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 565655004990 MgtE intracellular N domain; Region: MgtE_N; smart00924 565655004991 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 565655004992 Divalent cation transporter; Region: MgtE; pfam01769 565655004993 Predicted GTPases [General function prediction only]; Region: COG1162 565655004994 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 565655004995 RNA binding site [nucleotide binding]; other site 565655004996 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 565655004997 GTPase/Zn-binding domain interface [polypeptide binding]; other site 565655004998 GTP/Mg2+ binding site [chemical binding]; other site 565655004999 G4 box; other site 565655005000 G5 box; other site 565655005001 G1 box; other site 565655005002 Switch I region; other site 565655005003 G2 box; other site 565655005004 G3 box; other site 565655005005 Switch II region; other site 565655005006 Uncharacterized protein conserved in bacteria (DUF2200); Region: DUF2200; pfam09966 565655005007 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 565655005008 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 565655005009 metal ion-dependent adhesion site (MIDAS); other site 565655005010 TfoX C-terminal domain; Region: TfoX_C; pfam04994 565655005011 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 565655005012 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 565655005013 EDD domain protein, DegV family; Region: DegV; TIGR00762 565655005014 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 565655005015 Transcriptional regulator [Transcription]; Region: LytR; COG1316 565655005016 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 565655005017 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 565655005018 Coenzyme A binding pocket [chemical binding]; other site 565655005019 prephenate dehydratase; Provisional; Region: PRK11898 565655005020 Prephenate dehydratase; Region: PDT; pfam00800 565655005021 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 565655005022 putative L-Phe binding site [chemical binding]; other site 565655005023 shikimate kinase; Reviewed; Region: aroK; PRK00131 565655005024 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 565655005025 ADP binding site [chemical binding]; other site 565655005026 magnesium binding site [ion binding]; other site 565655005027 putative shikimate binding site; other site 565655005028 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 565655005029 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 565655005030 hinge; other site 565655005031 active site 565655005032 prephenate dehydrogenase; Validated; Region: PRK06545 565655005033 prephenate dehydrogenase; Validated; Region: PRK08507 565655005034 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 565655005035 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 565655005036 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 565655005037 Tetramer interface [polypeptide binding]; other site 565655005038 active site 565655005039 FMN-binding site [chemical binding]; other site 565655005040 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 565655005041 active site 565655005042 dimer interface [polypeptide binding]; other site 565655005043 metal binding site [ion binding]; metal-binding site 565655005044 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 565655005045 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 565655005046 shikimate 5-dehydrogenase; Provisional; Region: PRK12548 565655005047 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 565655005048 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 565655005049 shikimate binding site; other site 565655005050 NAD(P) binding site [chemical binding]; other site 565655005051 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 565655005052 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 565655005053 Walker A/P-loop; other site 565655005054 ATP binding site [chemical binding]; other site 565655005055 Q-loop/lid; other site 565655005056 ABC transporter signature motif; other site 565655005057 Walker B; other site 565655005058 D-loop; other site 565655005059 H-loop/switch region; other site 565655005060 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 565655005061 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 565655005062 TM-ABC transporter signature motif; other site 565655005063 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 565655005064 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 565655005065 zinc binding site [ion binding]; other site 565655005066 putative ligand binding site [chemical binding]; other site 565655005067 Protein of unknown function (DUF1622); Region: DUF1622; pfam07784 565655005068 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 565655005069 Domain of unknown function (DUF814); Region: DUF814; pfam05670 565655005070 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 565655005071 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 565655005072 Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124 565655005073 active site 565655005074 zinc binding site [ion binding]; other site 565655005075 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 565655005076 active site 565655005077 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 565655005078 active site 565655005079 dimer interface [polypeptide binding]; other site 565655005080 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 565655005081 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 565655005082 heterodimer interface [polypeptide binding]; other site 565655005083 active site 565655005084 FMN binding site [chemical binding]; other site 565655005085 homodimer interface [polypeptide binding]; other site 565655005086 substrate binding site [chemical binding]; other site 565655005087 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 565655005088 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 565655005089 FAD binding pocket [chemical binding]; other site 565655005090 FAD binding motif [chemical binding]; other site 565655005091 phosphate binding motif [ion binding]; other site 565655005092 beta-alpha-beta structure motif; other site 565655005093 NAD binding pocket [chemical binding]; other site 565655005094 Iron coordination center [ion binding]; other site 565655005095 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 565655005096 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 565655005097 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 565655005098 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 565655005099 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 565655005100 ATP-grasp domain; Region: ATP-grasp_4; cl17255 565655005101 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 565655005102 IMP binding site; other site 565655005103 dimer interface [polypeptide binding]; other site 565655005104 interdomain contacts; other site 565655005105 partial ornithine binding site; other site 565655005106 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 565655005107 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 565655005108 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 565655005109 catalytic site [active] 565655005110 subunit interface [polypeptide binding]; other site 565655005111 dihydroorotase; Validated; Region: pyrC; PRK09357 565655005112 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 565655005113 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 565655005114 active site 565655005115 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 565655005116 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 565655005117 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 565655005118 uracil transporter; Provisional; Region: PRK10720 565655005119 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 565655005120 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 565655005121 active site 565655005122 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 565655005123 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 565655005124 RNA binding surface [nucleotide binding]; other site 565655005125 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 565655005126 active site 565655005127 lipoprotein signal peptidase; Provisional; Region: PRK14787 565655005128 lipoprotein signal peptidase; Provisional; Region: PRK14797 565655005129 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 565655005130 FOG: CBS domain [General function prediction only]; Region: COG0517 565655005131 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 565655005132 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 565655005133 Potassium binding sites [ion binding]; other site 565655005134 Cesium cation binding sites [ion binding]; other site 565655005135 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 565655005136 RNA/DNA hybrid binding site [nucleotide binding]; other site 565655005137 active site 565655005138 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 565655005139 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 565655005140 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 565655005141 putative active site [active] 565655005142 catalytic site [active] 565655005143 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 565655005144 putative active site [active] 565655005145 catalytic site [active] 565655005146 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 565655005147 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 565655005148 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 565655005149 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 565655005150 motif 1; other site 565655005151 active site 565655005152 motif 2; other site 565655005153 motif 3; other site 565655005154 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 565655005155 DHHA1 domain; Region: DHHA1; pfam02272 565655005156 Pleckstrin homology-like domain; Region: PH-like; cl17171 565655005157 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 565655005158 Coenzyme A binding pocket [chemical binding]; other site 565655005159 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 565655005160 DEAD-like helicases superfamily; Region: DEXDc; smart00487 565655005161 ATP binding site [chemical binding]; other site 565655005162 Mg++ binding site [ion binding]; other site 565655005163 motif III; other site 565655005164 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 565655005165 nucleotide binding region [chemical binding]; other site 565655005166 ATP-binding site [chemical binding]; other site 565655005167 VanZ like family; Region: VanZ; cl01971 565655005168 RDD family; Region: RDD; pfam06271 565655005169 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 565655005170 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 565655005171 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 565655005172 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 565655005173 active site 565655005174 Zn binding site [ion binding]; other site 565655005175 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 565655005176 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 565655005177 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 565655005178 cell division protein GpsB; Provisional; Region: PRK14127 565655005179 DivIVA domain; Region: DivI1A_domain; TIGR03544 565655005180 hypothetical protein; Provisional; Region: PRK13660 565655005181 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 565655005182 Transglycosylase; Region: Transgly; pfam00912 565655005183 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 565655005184 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 565655005185 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 565655005186 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 565655005187 Catalytic site [active] 565655005188 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 565655005189 CHAP domain; Region: CHAP; pfam05257 565655005190 WxL domain surface cell wall-binding; Region: WxL; pfam13731 565655005191 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 565655005192 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 565655005193 WxL domain surface cell wall-binding; Region: WxL; pfam13731 565655005194 WxL domain surface cell wall-binding; Region: WxL; pfam13731 565655005195 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 565655005196 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 565655005197 minor groove reading motif; other site 565655005198 helix-hairpin-helix signature motif; other site 565655005199 substrate binding pocket [chemical binding]; other site 565655005200 active site 565655005201 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 565655005202 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 565655005203 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 565655005204 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 565655005205 homotrimer interaction site [polypeptide binding]; other site 565655005206 putative active site [active] 565655005207 ferric uptake regulator; Provisional; Region: fur; PRK09462 565655005208 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 565655005209 metal binding site 2 [ion binding]; metal-binding site 565655005210 putative DNA binding helix; other site 565655005211 metal binding site 1 [ion binding]; metal-binding site 565655005212 dimer interface [polypeptide binding]; other site 565655005213 structural Zn2+ binding site [ion binding]; other site 565655005214 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 565655005215 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 565655005216 dimer interface [polypeptide binding]; other site 565655005217 pyridoxal 5'-phosphate binding site [chemical binding]; other site 565655005218 catalytic residue [active] 565655005219 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 565655005220 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 565655005221 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 565655005222 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 565655005223 TPP-binding site [chemical binding]; other site 565655005224 dimer interface [polypeptide binding]; other site 565655005225 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 565655005226 PYR/PP interface [polypeptide binding]; other site 565655005227 dimer interface [polypeptide binding]; other site 565655005228 TPP binding site [chemical binding]; other site 565655005229 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 565655005230 Bacterial protein of unknown function (DUF896); Region: DUF896; cl01722 565655005231 LexA repressor; Validated; Region: PRK00215 565655005232 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 565655005233 putative DNA binding site [nucleotide binding]; other site 565655005234 putative Zn2+ binding site [ion binding]; other site 565655005235 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 565655005236 Catalytic site [active] 565655005237 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 565655005238 active site 565655005239 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 565655005240 DHH family; Region: DHH; pfam01368 565655005241 DHHA1 domain; Region: DHHA1; pfam02272 565655005242 Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; pfam10141 565655005243 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 565655005244 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 565655005245 NAD(P) binding site [chemical binding]; other site 565655005246 active site 565655005247 ribonuclease Z; Region: RNase_Z; TIGR02651 565655005248 GTPase CgtA; Reviewed; Region: obgE; PRK12297 565655005249 GTP1/OBG; Region: GTP1_OBG; pfam01018 565655005250 Obg GTPase; Region: Obg; cd01898 565655005251 G1 box; other site 565655005252 GTP/Mg2+ binding site [chemical binding]; other site 565655005253 Switch I region; other site 565655005254 G2 box; other site 565655005255 G3 box; other site 565655005256 Switch II region; other site 565655005257 G4 box; other site 565655005258 G5 box; other site 565655005259 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 565655005260 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 565655005261 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 565655005262 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 565655005263 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 565655005264 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 565655005265 Uncharacterized conserved protein [Function unknown]; Region: COG3589 565655005266 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 565655005267 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 565655005268 active site 565655005269 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 565655005270 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK06079 565655005271 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 565655005272 NAD binding site [chemical binding]; other site 565655005273 homotetramer interface [polypeptide binding]; other site 565655005274 homodimer interface [polypeptide binding]; other site 565655005275 substrate binding site [chemical binding]; other site 565655005276 active site 565655005277 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 565655005278 Mechanosensitive ion channel; Region: MS_channel; pfam00924 565655005279 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 565655005280 FOG: CBS domain [General function prediction only]; Region: COG0517 565655005281 Predicted phosphoesterases, related to the Icc protein [General function prediction only]; Region: COG2129 565655005282 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 565655005283 active site 565655005284 metal binding site [ion binding]; metal-binding site 565655005285 homotetramer interface [polypeptide binding]; other site 565655005286 ribonuclease PH; Reviewed; Region: rph; PRK00173 565655005287 Ribonuclease PH; Region: RNase_PH_bact; cd11362 565655005288 hexamer interface [polypeptide binding]; other site 565655005289 active site 565655005290 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 565655005291 active site 565655005292 dimerization interface [polypeptide binding]; other site 565655005293 glutamate racemase; Provisional; Region: PRK00865 565655005294 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 565655005295 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 565655005296 dimer interface [polypeptide binding]; other site 565655005297 conserved gate region; other site 565655005298 putative PBP binding loops; other site 565655005299 ABC-ATPase subunit interface; other site 565655005300 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 565655005301 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 565655005302 dimer interface [polypeptide binding]; other site 565655005303 conserved gate region; other site 565655005304 putative PBP binding loops; other site 565655005305 ABC-ATPase subunit interface; other site 565655005306 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 565655005307 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 565655005308 substrate binding pocket [chemical binding]; other site 565655005309 membrane-bound complex binding site; other site 565655005310 hinge residues; other site 565655005311 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 565655005312 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 565655005313 Walker A/P-loop; other site 565655005314 ATP binding site [chemical binding]; other site 565655005315 Q-loop/lid; other site 565655005316 ABC transporter signature motif; other site 565655005317 Walker B; other site 565655005318 D-loop; other site 565655005319 H-loop/switch region; other site 565655005320 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 565655005321 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 565655005322 active site 565655005323 HIGH motif; other site 565655005324 dimer interface [polypeptide binding]; other site 565655005325 KMSKS motif; other site 565655005326 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 565655005327 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 565655005328 putative tRNA-binding site [nucleotide binding]; other site 565655005329 B3/4 domain; Region: B3_4; pfam03483 565655005330 tRNA synthetase B5 domain; Region: B5; smart00874 565655005331 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 565655005332 dimer interface [polypeptide binding]; other site 565655005333 motif 1; other site 565655005334 motif 3; other site 565655005335 motif 2; other site 565655005336 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 565655005337 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 565655005338 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 565655005339 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 565655005340 dimer interface [polypeptide binding]; other site 565655005341 motif 1; other site 565655005342 active site 565655005343 motif 2; other site 565655005344 motif 3; other site 565655005345 Predicted transcriptional regulators [Transcription]; Region: COG1733 565655005346 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 565655005347 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 565655005348 Part of AAA domain; Region: AAA_19; pfam13245 565655005349 Family description; Region: UvrD_C_2; pfam13538 565655005350 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 565655005351 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 565655005352 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 565655005353 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 565655005354 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 565655005355 Catalytic site [active] 565655005356 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 565655005357 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 565655005358 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 565655005359 tetramerization interface [polypeptide binding]; other site 565655005360 NAD(P) binding site [chemical binding]; other site 565655005361 catalytic residues [active] 565655005362 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 565655005363 dimer interface [polypeptide binding]; other site 565655005364 FMN binding site [chemical binding]; other site 565655005365 Short repeat of unknown function (DUF308); Region: DUF308; cl15828 565655005366 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 565655005367 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 565655005368 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 565655005369 motif II; other site 565655005370 electron transport complex, RnfABCDGE type, C subunit; Region: rnfC; TIGR01945 565655005371 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 565655005372 SLBB domain; Region: SLBB; pfam10531 565655005373 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 565655005374 NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; pfam03116 565655005375 Peptidase family C69; Region: Peptidase_C69; pfam03577 565655005376 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 565655005377 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 565655005378 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 565655005379 homodimer interface [polypeptide binding]; other site 565655005380 substrate-cofactor binding pocket; other site 565655005381 pyridoxal 5'-phosphate binding site [chemical binding]; other site 565655005382 catalytic residue [active] 565655005383 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 565655005384 Domain of unknown function DUF20; Region: UPF0118; pfam01594 565655005385 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 565655005386 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 565655005387 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 565655005388 Coenzyme A binding pocket [chemical binding]; other site 565655005389 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 565655005390 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 565655005391 active site 565655005392 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 565655005393 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 565655005394 MutS domain III; Region: MutS_III; pfam05192 565655005395 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 565655005396 Walker A/P-loop; other site 565655005397 ATP binding site [chemical binding]; other site 565655005398 Q-loop/lid; other site 565655005399 ABC transporter signature motif; other site 565655005400 Walker B; other site 565655005401 D-loop; other site 565655005402 H-loop/switch region; other site 565655005403 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 565655005404 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 565655005405 catalytic residue [active] 565655005406 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 565655005407 catalytic residues [active] 565655005408 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 565655005409 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 565655005410 peroxiredoxin; Region: AhpC; TIGR03137 565655005411 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 565655005412 dimer interface [polypeptide binding]; other site 565655005413 decamer (pentamer of dimers) interface [polypeptide binding]; other site 565655005414 catalytic triad [active] 565655005415 peroxidatic and resolving cysteines [active] 565655005416 Predicted transcriptional regulators [Transcription]; Region: COG1695 565655005417 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 565655005418 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 565655005419 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 565655005420 putative ligand binding residues [chemical binding]; other site 565655005421 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 565655005422 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 565655005423 Walker A/P-loop; other site 565655005424 ATP binding site [chemical binding]; other site 565655005425 Q-loop/lid; other site 565655005426 ABC transporter signature motif; other site 565655005427 Walker B; other site 565655005428 D-loop; other site 565655005429 H-loop/switch region; other site 565655005430 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 565655005431 ABC-ATPase subunit interface; other site 565655005432 dimer interface [polypeptide binding]; other site 565655005433 putative PBP binding regions; other site 565655005434 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 565655005435 ABC-ATPase subunit interface; other site 565655005436 dimer interface [polypeptide binding]; other site 565655005437 putative PBP binding regions; other site 565655005438 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 565655005439 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 565655005440 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 565655005441 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 565655005442 Mga helix-turn-helix domain; Region: Mga; pfam05043 565655005443 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 565655005444 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 565655005445 transmembrane helices; other site 565655005446 Methyltransferase domain; Region: Methyltransf_25; pfam13649 565655005447 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 565655005448 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 565655005449 putative NAD(P) binding site [chemical binding]; other site 565655005450 dimer interface [polypeptide binding]; other site 565655005451 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 565655005452 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 565655005453 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 565655005454 Coenzyme A binding pocket [chemical binding]; other site 565655005455 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 565655005456 Dihydroorotate dehydrogenase (DHOD) class 1A FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1A_like; cd04741 565655005457 active site 565655005458 FMN binding site [chemical binding]; other site 565655005459 substrate binding site [chemical binding]; other site 565655005460 catalytic residues [active] 565655005461 homodimer interface [polypeptide binding]; other site 565655005462 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 565655005463 NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236 565655005464 putative NAD(P) binding site [chemical binding]; other site 565655005465 catalytic Zn binding site [ion binding]; other site 565655005466 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 565655005467 intersubunit interface [polypeptide binding]; other site 565655005468 active site 565655005469 Zn2+ binding site [ion binding]; other site 565655005470 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 565655005471 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 565655005472 active site 565655005473 P-loop; other site 565655005474 phosphorylation site [posttranslational modification] 565655005475 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 565655005476 active site 565655005477 phosphorylation site [posttranslational modification] 565655005478 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 565655005479 active site 565655005480 phosphorylation site [posttranslational modification] 565655005481 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 565655005482 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 565655005483 active site 565655005484 P-loop; other site 565655005485 phosphorylation site [posttranslational modification] 565655005486 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 565655005487 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 565655005488 NAD(P) binding site [chemical binding]; other site 565655005489 Protein of unknown function (DUF2500); Region: DUF2500; pfam10694 565655005490 Mga helix-turn-helix domain; Region: Mga; pfam05043 565655005491 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 565655005492 phospholipase D; Region: PLN02866 565655005493 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 565655005494 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 565655005495 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 565655005496 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 565655005497 catalytic residues [active] 565655005498 catalytic nucleophile [active] 565655005499 Presynaptic Site I dimer interface [polypeptide binding]; other site 565655005500 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 565655005501 Synaptic Flat tetramer interface [polypeptide binding]; other site 565655005502 Synaptic Site I dimer interface [polypeptide binding]; other site 565655005503 DNA binding site [nucleotide binding] 565655005504 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 565655005505 active site 565655005506 DNA binding site [nucleotide binding] 565655005507 Int/Topo IB signature motif; other site 565655005508 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 565655005509 active site 565655005510 DNA binding site [nucleotide binding] 565655005511 Int/Topo IB signature motif; other site 565655005512 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 565655005513 Uncharacterized conserved protein [Function unknown]; Region: COG1284 565655005514 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 565655005515 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 565655005516 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 565655005517 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 565655005518 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 565655005519 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 565655005520 DEAD/DEAH box helicase; Region: DEAD; pfam00270 565655005521 DEAD_2; Region: DEAD_2; pfam06733 565655005522 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 565655005523 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 565655005524 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 565655005525 Coenzyme A binding pocket [chemical binding]; other site 565655005526 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 565655005527 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 565655005528 catalytic core [active] 565655005529 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 565655005530 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 565655005531 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 565655005532 Phosphate transporter family; Region: PHO4; pfam01384 565655005533 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 565655005534 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 565655005535 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 565655005536 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 565655005537 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 565655005538 Competence protein; Region: Competence; pfam03772 565655005539 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 565655005540 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 565655005541 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 565655005542 catalytic motif [active] 565655005543 Zn binding site [ion binding]; other site 565655005544 SLBB domain; Region: SLBB; pfam10531 565655005545 comEA protein; Region: comE; TIGR01259 565655005546 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 565655005547 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 565655005548 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 565655005549 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 565655005550 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 565655005551 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 565655005552 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 565655005553 active site 565655005554 phosphorylation site [posttranslational modification] 565655005555 intermolecular recognition site; other site 565655005556 dimerization interface [polypeptide binding]; other site 565655005557 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 565655005558 DNA binding site [nucleotide binding] 565655005559 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 565655005560 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 565655005561 dimerization interface [polypeptide binding]; other site 565655005562 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 565655005563 dimer interface [polypeptide binding]; other site 565655005564 phosphorylation site [posttranslational modification] 565655005565 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 565655005566 ATP binding site [chemical binding]; other site 565655005567 Mg2+ binding site [ion binding]; other site 565655005568 G-X-G motif; other site 565655005569 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 565655005570 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 565655005571 motif II; other site 565655005572 Repair protein; Region: Repair_PSII; pfam04536 565655005573 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 565655005574 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 565655005575 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 565655005576 catalytic core [active] 565655005577 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 565655005578 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 565655005579 substrate binding pocket [chemical binding]; other site 565655005580 membrane-bound complex binding site; other site 565655005581 hinge residues; other site 565655005582 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 565655005583 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 565655005584 dimer interface [polypeptide binding]; other site 565655005585 conserved gate region; other site 565655005586 ABC-ATPase subunit interface; other site 565655005587 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 565655005588 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 565655005589 Walker A/P-loop; other site 565655005590 ATP binding site [chemical binding]; other site 565655005591 Q-loop/lid; other site 565655005592 ABC transporter signature motif; other site 565655005593 Walker B; other site 565655005594 D-loop; other site 565655005595 H-loop/switch region; other site 565655005596 aspartate aminotransferase; Provisional; Region: PRK06348 565655005597 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 565655005598 pyridoxal 5'-phosphate binding site [chemical binding]; other site 565655005599 homodimer interface [polypeptide binding]; other site 565655005600 catalytic residue [active] 565655005601 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 565655005602 Major Facilitator Superfamily; Region: MFS_1; pfam07690 565655005603 putative substrate translocation pore; other site 565655005604 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 565655005605 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 565655005606 DNA binding residues [nucleotide binding] 565655005607 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 565655005608 putative dimer interface [polypeptide binding]; other site 565655005609 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 565655005610 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 565655005611 putative active site cavity [active] 565655005612 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 565655005613 pyruvate oxidase; Region: pyruv_oxi_spxB; TIGR02720 565655005614 PYR/PP interface [polypeptide binding]; other site 565655005615 dimer interface [polypeptide binding]; other site 565655005616 tetramer interface [polypeptide binding]; other site 565655005617 TPP binding site [chemical binding]; other site 565655005618 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 565655005619 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 565655005620 TPP-binding site [chemical binding]; other site 565655005621 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 565655005622 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 565655005623 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 565655005624 active site 565655005625 substrate binding site [chemical binding]; other site 565655005626 trimer interface [polypeptide binding]; other site 565655005627 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 565655005628 CoA binding site [chemical binding]; other site 565655005629 Uncharacterized conserved protein [Function unknown]; Region: COG4925 565655005630 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 565655005631 Toxin YafO, type II toxin-antitoxin system; Region: YafO_toxin; cl08066 565655005632 Transcriptional regulator [Transcription]; Region: LysR; COG0583 565655005633 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 565655005634 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 565655005635 dimerization interface [polypeptide binding]; other site 565655005636 Protein of unknown function (DUF3788); Region: DUF3788; pfam12663 565655005637 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 565655005638 Beta-lactamase; Region: Beta-lactamase; pfam00144 565655005639 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 565655005640 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 565655005641 Peptidase family M23; Region: Peptidase_M23; pfam01551 565655005642 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 565655005643 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 565655005644 FtsX-like permease family; Region: FtsX; pfam02687 565655005645 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 565655005646 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 565655005647 Walker A/P-loop; other site 565655005648 ATP binding site [chemical binding]; other site 565655005649 Q-loop/lid; other site 565655005650 ABC transporter signature motif; other site 565655005651 Walker B; other site 565655005652 D-loop; other site 565655005653 H-loop/switch region; other site 565655005654 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 565655005655 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 565655005656 ATP binding site [chemical binding]; other site 565655005657 Mg2+ binding site [ion binding]; other site 565655005658 G-X-G motif; other site 565655005659 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 565655005660 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 565655005661 active site 565655005662 phosphorylation site [posttranslational modification] 565655005663 intermolecular recognition site; other site 565655005664 dimerization interface [polypeptide binding]; other site 565655005665 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 565655005666 DNA binding site [nucleotide binding] 565655005667 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 565655005668 Prenyltransferase-like; Region: Prenyltrans_1; pfam13243 565655005669 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 565655005670 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 565655005671 active site 565655005672 metal binding site [ion binding]; metal-binding site 565655005673 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270 565655005674 Predicted RNA-binding protein, contains TRAM domain [General function prediction only]; Region: COG3269 565655005675 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 565655005676 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 565655005677 S-adenosylmethionine binding site [chemical binding]; other site 565655005678 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 565655005679 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 565655005680 G1 box; other site 565655005681 putative GEF interaction site [polypeptide binding]; other site 565655005682 GTP/Mg2+ binding site [chemical binding]; other site 565655005683 Switch I region; other site 565655005684 G2 box; other site 565655005685 G3 box; other site 565655005686 Switch II region; other site 565655005687 G4 box; other site 565655005688 G5 box; other site 565655005689 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 565655005690 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 565655005691 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 565655005692 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 565655005693 active site 565655005694 Uncharacterized protein family (UPF0223); Region: UPF0223; cl11484 565655005695 intracellular protease, PfpI family; Region: PfpI; TIGR01382 565655005696 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 565655005697 proposed catalytic triad [active] 565655005698 conserved cys residue [active] 565655005699 OAH/OAS sulfhydrylase; Region: OAH_OAS_sulfhy; TIGR01326 565655005700 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 565655005701 homodimer interface [polypeptide binding]; other site 565655005702 substrate-cofactor binding pocket; other site 565655005703 pyridoxal 5'-phosphate binding site [chemical binding]; other site 565655005704 catalytic residue [active] 565655005705 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 565655005706 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 565655005707 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 565655005708 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 565655005709 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 565655005710 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 565655005711 E3 interaction surface; other site 565655005712 lipoyl attachment site [posttranslational modification]; other site 565655005713 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 565655005714 E3 interaction surface; other site 565655005715 lipoyl attachment site [posttranslational modification]; other site 565655005716 e3 binding domain; Region: E3_binding; pfam02817 565655005717 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 565655005718 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 565655005719 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 565655005720 alpha subunit interface [polypeptide binding]; other site 565655005721 TPP binding site [chemical binding]; other site 565655005722 heterodimer interface [polypeptide binding]; other site 565655005723 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 565655005724 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 565655005725 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 565655005726 tetramer interface [polypeptide binding]; other site 565655005727 TPP-binding site [chemical binding]; other site 565655005728 heterodimer interface [polypeptide binding]; other site 565655005729 phosphorylation loop region [posttranslational modification] 565655005730 magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517 565655005731 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 565655005732 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 565655005733 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 565655005734 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 565655005735 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 565655005736 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 565655005737 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 565655005738 active site 565655005739 homodimer interface [polypeptide binding]; other site 565655005740 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 565655005741 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 565655005742 active site 565655005743 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 565655005744 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 565655005745 active site 565655005746 catalytic tetrad [active] 565655005747 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 565655005748 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 565655005749 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 565655005750 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 565655005751 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 565655005752 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 565655005753 purine monophosphate binding site [chemical binding]; other site 565655005754 dimer interface [polypeptide binding]; other site 565655005755 putative catalytic residues [active] 565655005756 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 565655005757 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 565655005758 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 565655005759 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 565655005760 active site 565655005761 substrate binding site [chemical binding]; other site 565655005762 cosubstrate binding site; other site 565655005763 catalytic site [active] 565655005764 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 565655005765 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 565655005766 dimerization interface [polypeptide binding]; other site 565655005767 putative ATP binding site [chemical binding]; other site 565655005768 amidophosphoribosyltransferase; Provisional; Region: PRK07272 565655005769 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 565655005770 active site 565655005771 tetramer interface [polypeptide binding]; other site 565655005772 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 565655005773 active site 565655005774 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 565655005775 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 565655005776 dimerization interface [polypeptide binding]; other site 565655005777 ATP binding site [chemical binding]; other site 565655005778 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 565655005779 dimerization interface [polypeptide binding]; other site 565655005780 ATP binding site [chemical binding]; other site 565655005781 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 565655005782 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 565655005783 putative active site [active] 565655005784 catalytic triad [active] 565655005785 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700 565655005786 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 565655005787 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 565655005788 ATP binding site [chemical binding]; other site 565655005789 active site 565655005790 substrate binding site [chemical binding]; other site 565655005791 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4493 565655005792 Protein of unknown function (DUF1054); Region: DUF1054; pfam06335 565655005793 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 565655005794 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 565655005795 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 565655005796 adenylosuccinate lyase; Provisional; Region: PRK07492 565655005797 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 565655005798 tetramer interface [polypeptide binding]; other site 565655005799 active site 565655005800 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 565655005801 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 565655005802 NAD binding site [chemical binding]; other site 565655005803 ATP-grasp domain; Region: ATP-grasp; pfam02222 565655005804 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 565655005805 xanthine permease; Region: pbuX; TIGR03173 565655005806 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 565655005807 active site 565655005808 Class I aldolases; Region: Aldolase_Class_I; cl17187 565655005809 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 565655005810 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 565655005811 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 565655005812 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 565655005813 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 565655005814 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 565655005815 Predicted membrane protein [Function unknown]; Region: COG4129 565655005816 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 565655005817 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 565655005818 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 565655005819 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 565655005820 FtsX-like permease family; Region: FtsX; pfam02687 565655005821 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 565655005822 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 565655005823 FtsX-like permease family; Region: FtsX; pfam02687 565655005824 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 565655005825 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 565655005826 Walker A/P-loop; other site 565655005827 ATP binding site [chemical binding]; other site 565655005828 Q-loop/lid; other site 565655005829 ABC transporter signature motif; other site 565655005830 Walker B; other site 565655005831 D-loop; other site 565655005832 H-loop/switch region; other site 565655005833 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 565655005834 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 565655005835 putative NAD(P) binding site [chemical binding]; other site 565655005836 active site 565655005837 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 565655005838 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 565655005839 active site 565655005840 dimer interface [polypeptide binding]; other site 565655005841 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 565655005842 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 565655005843 non-specific DNA binding site [nucleotide binding]; other site 565655005844 salt bridge; other site 565655005845 sequence-specific DNA binding site [nucleotide binding]; other site 565655005846 Tetratricopeptide repeat; Region: TPR_12; pfam13424 565655005847 aminotransferase AlaT; Validated; Region: PRK09265 565655005848 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 565655005849 pyridoxal 5'-phosphate binding site [chemical binding]; other site 565655005850 homodimer interface [polypeptide binding]; other site 565655005851 catalytic residue [active] 565655005852 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 565655005853 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 565655005854 Walker A/P-loop; other site 565655005855 ATP binding site [chemical binding]; other site 565655005856 Q-loop/lid; other site 565655005857 ABC transporter signature motif; other site 565655005858 Walker B; other site 565655005859 D-loop; other site 565655005860 H-loop/switch region; other site 565655005861 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 565655005862 Host cell surface-exposed lipoprotein; Region: Lipoprotein_Ltp; pfam07553 565655005863 Host cell surface-exposed lipoprotein; Region: Lipoprotein_Ltp; pfam07553 565655005864 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 565655005865 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 565655005866 putative metal binding site [ion binding]; other site 565655005867 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 565655005868 active site 565655005869 metal binding site [ion binding]; metal-binding site 565655005870 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 565655005871 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 565655005872 Metal-binding active site; metal-binding site 565655005873 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 565655005874 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 565655005875 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 565655005876 inhibitor binding site; inhibition site 565655005877 active site 565655005878 putative pectinesterase; Region: PLN02432; cl01911 565655005879 Abhydrolase family; Region: Abhydrolase_7; pfam12715 565655005880 Endopygalactorunase [Cell envelope biogenesis, outer membrane]; Region: PGU1; COG5434 565655005881 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 565655005882 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 565655005883 Protein of unknown function, DUF624; Region: DUF624; cl02369 565655005884 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 565655005885 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 565655005886 dimer interface [polypeptide binding]; other site 565655005887 conserved gate region; other site 565655005888 ABC-ATPase subunit interface; other site 565655005889 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 565655005890 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 565655005891 dimer interface [polypeptide binding]; other site 565655005892 conserved gate region; other site 565655005893 putative PBP binding loops; other site 565655005894 ABC-ATPase subunit interface; other site 565655005895 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 565655005896 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 565655005897 Transcriptional regulators [Transcription]; Region: PurR; COG1609 565655005898 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 565655005899 DNA binding site [nucleotide binding] 565655005900 domain linker motif; other site 565655005901 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 565655005902 dimerization interface [polypeptide binding]; other site 565655005903 ligand binding site [chemical binding]; other site 565655005904 altronate oxidoreductase; Provisional; Region: PRK03643 565655005905 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 565655005906 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 565655005907 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 565655005908 galactarate dehydratase; Region: galactar-dH20; TIGR03248 565655005909 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 565655005910 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 565655005911 Glucuronate isomerase; Region: UxaC; pfam02614 565655005912 Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821 565655005913 active site 565655005914 catalytic triad [active] 565655005915 gluconate 5-dehydrogenase; Provisional; Region: PRK07097 565655005916 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 565655005917 NADP binding site [chemical binding]; other site 565655005918 homodimer interface [polypeptide binding]; other site 565655005919 active site 565655005920 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 565655005921 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 565655005922 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 565655005923 substrate binding site [chemical binding]; other site 565655005924 ATP binding site [chemical binding]; other site 565655005925 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 565655005926 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 565655005927 active site 565655005928 intersubunit interface [polypeptide binding]; other site 565655005929 catalytic residue [active] 565655005930 Transcriptional regulator [Transcription]; Region: IclR; COG1414 565655005931 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 565655005932 Bacterial transcriptional regulator; Region: IclR; pfam01614 565655005933 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 565655005934 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 565655005935 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 565655005936 putative active site [active] 565655005937 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 565655005938 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 565655005939 nucleotide binding site [chemical binding]; other site 565655005940 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 565655005941 Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298 565655005942 NAD binding site [chemical binding]; other site 565655005943 sugar binding site [chemical binding]; other site 565655005944 divalent metal binding site [ion binding]; other site 565655005945 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 565655005946 dimer interface [polypeptide binding]; other site 565655005947 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 565655005948 bifunctional PTS system maltose and glucose-specific transporter subunits IICB; Provisional; Region: PRK10110 565655005949 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 565655005950 active site turn [active] 565655005951 phosphorylation site [posttranslational modification] 565655005952 legume lectins; Region: lectin_L-type; cd01951 565655005953 homotetramer interaction site [polypeptide binding]; other site 565655005954 carbohydrate binding site [chemical binding]; other site 565655005955 metal binding site [ion binding]; metal-binding site 565655005956 WxL domain surface cell wall-binding; Region: WxL; pfam13731 565655005957 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 565655005958 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 565655005959 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 565655005960 putative active site [active] 565655005961 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 565655005962 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 565655005963 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 565655005964 Coenzyme A binding pocket [chemical binding]; other site 565655005965 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 565655005966 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 565655005967 ATP binding site [chemical binding]; other site 565655005968 putative Mg++ binding site [ion binding]; other site 565655005969 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 565655005970 nucleotide binding region [chemical binding]; other site 565655005971 ATP-binding site [chemical binding]; other site 565655005972 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 565655005973 HRDC domain; Region: HRDC; pfam00570 565655005974 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 565655005975 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 565655005976 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 565655005977 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 565655005978 metal binding site [ion binding]; metal-binding site 565655005979 YodA lipocalin-like domain; Region: YodA; pfam09223 565655005980 YKOF-related Family; Region: Ykof; pfam07615 565655005981 YKOF-related Family; Region: Ykof; pfam07615 565655005982 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; pfam09819 565655005983 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 565655005984 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 565655005985 Walker A/P-loop; other site 565655005986 ATP binding site [chemical binding]; other site 565655005987 Q-loop/lid; other site 565655005988 ABC transporter signature motif; other site 565655005989 Walker B; other site 565655005990 D-loop; other site 565655005991 H-loop/switch region; other site 565655005992 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 565655005993 Walker A/P-loop; other site 565655005994 ATP binding site [chemical binding]; other site 565655005995 Q-loop/lid; other site 565655005996 ABC transporter signature motif; other site 565655005997 Walker B; other site 565655005998 D-loop; other site 565655005999 H-loop/switch region; other site 565655006000 Signal peptidase I [Intracellular trafficking and secretion]; Region: LepB; COG0681 565655006001 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462 565655006002 Catalytic site [active] 565655006003 Protein of unknown function (DUF3533); Region: DUF3533; pfam12051 565655006004 prolyl-tRNA synthetase; Provisional; Region: PRK08661 565655006005 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778 565655006006 dimer interface [polypeptide binding]; other site 565655006007 motif 1; other site 565655006008 active site 565655006009 motif 2; other site 565655006010 motif 3; other site 565655006011 ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862 565655006012 anticodon binding site; other site 565655006013 zinc-binding site [ion binding]; other site 565655006014 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 565655006015 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 565655006016 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 565655006017 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 565655006018 Protein of unknown function (DUF975); Region: DUF975; cl10504 565655006019 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 565655006020 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 565655006021 oligomer interface [polypeptide binding]; other site 565655006022 active site 565655006023 metal binding site [ion binding]; metal-binding site 565655006024 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 565655006025 FtsX-like permease family; Region: FtsX; pfam02687 565655006026 FtsX-like permease family; Region: FtsX; pfam02687 565655006027 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 565655006028 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 565655006029 Walker A/P-loop; other site 565655006030 ATP binding site [chemical binding]; other site 565655006031 Q-loop/lid; other site 565655006032 ABC transporter signature motif; other site 565655006033 Walker B; other site 565655006034 D-loop; other site 565655006035 H-loop/switch region; other site 565655006036 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 565655006037 ATP cone domain; Region: ATP-cone; pfam03477 565655006038 Class III ribonucleotide reductase; Region: RNR_III; cd01675 565655006039 effector binding site; other site 565655006040 active site 565655006041 Zn binding site [ion binding]; other site 565655006042 glycine loop; other site 565655006043 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804 565655006044 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 565655006045 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 565655006046 A new structural DNA glycosylase containing HEAT-like repeats; Region: AlkD_like_1; cd07064 565655006047 active site 565655006048 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 565655006049 active site 565655006050 DNA polymerase IV; Validated; Region: PRK02406 565655006051 DNA binding site [nucleotide binding] 565655006052 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 565655006053 Nitrogen regulatory protein P-II; Region: P-II; smart00938 565655006054 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 565655006055 Predicted methyltransferases [General function prediction only]; Region: COG0313 565655006056 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 565655006057 putative SAM binding site [chemical binding]; other site 565655006058 putative homodimer interface [polypeptide binding]; other site 565655006059 Protein of unknown function (DUF972); Region: DUF972; pfam06156 565655006060 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 565655006061 DNA polymerase III subunit delta'; Validated; Region: PRK08058 565655006062 DNA polymerase III subunit delta'; Validated; Region: PRK08485 565655006063 Protein of unknown function (DUF970); Region: DUF970; pfam06153 565655006064 thymidylate kinase; Validated; Region: tmk; PRK00698 565655006065 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 565655006066 TMP-binding site; other site 565655006067 ATP-binding site [chemical binding]; other site 565655006068 recombination protein RecR; Reviewed; Region: recR; PRK00076 565655006069 RecR protein; Region: RecR; pfam02132 565655006070 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 565655006071 putative active site [active] 565655006072 putative metal-binding site [ion binding]; other site 565655006073 tetramer interface [polypeptide binding]; other site 565655006074 hypothetical protein; Validated; Region: PRK00153 565655006075 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 565655006076 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 565655006077 Walker A motif; other site 565655006078 ATP binding site [chemical binding]; other site 565655006079 Walker B motif; other site 565655006080 arginine finger; other site 565655006081 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 565655006082 Membrane protease subunit, stomatin/prohibitin family [Amino acid transport and metabolism]; Region: COG4260 565655006083 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_5; cd03408 565655006084 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 565655006085 Repair protein; Region: Repair_PSII; pfam04536 565655006086 hypothetical protein; Provisional; Region: PRK06815 565655006087 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 565655006088 tetramer interface [polypeptide binding]; other site 565655006089 pyridoxal 5'-phosphate binding site [chemical binding]; other site 565655006090 catalytic residue [active] 565655006091 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 565655006092 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 565655006093 homodimer interface [polypeptide binding]; other site 565655006094 substrate-cofactor binding pocket; other site 565655006095 catalytic residue [active] 565655006096 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 565655006097 core dimer interface [polypeptide binding]; other site 565655006098 peripheral dimer interface [polypeptide binding]; other site 565655006099 L10 interface [polypeptide binding]; other site 565655006100 L11 interface [polypeptide binding]; other site 565655006101 putative EF-Tu interaction site [polypeptide binding]; other site 565655006102 putative EF-G interaction site [polypeptide binding]; other site 565655006103 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 565655006104 23S rRNA interface [nucleotide binding]; other site 565655006105 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 565655006106 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 565655006107 mRNA/rRNA interface [nucleotide binding]; other site 565655006108 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 565655006109 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 565655006110 23S rRNA interface [nucleotide binding]; other site 565655006111 L7/L12 interface [polypeptide binding]; other site 565655006112 putative thiostrepton binding site; other site 565655006113 L25 interface [polypeptide binding]; other site 565655006114 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 565655006115 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 565655006116 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 565655006117 putative L-serine binding site [chemical binding]; other site 565655006118 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 565655006119 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 565655006120 Protein of unknown function (DUF1576); Region: DUF1576; pfam07613 565655006121 Protein of unknown function (DUF1576); Region: DUF1576; pfam07613 565655006122 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 565655006123 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 565655006124 putative homodimer interface [polypeptide binding]; other site 565655006125 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 565655006126 heterodimer interface [polypeptide binding]; other site 565655006127 homodimer interface [polypeptide binding]; other site 565655006128 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 565655006129 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 565655006130 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 565655006131 QueT transporter; Region: QueT; pfam06177 565655006132 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 565655006133 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 565655006134 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 565655006135 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 565655006136 active site 565655006137 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 565655006138 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 565655006139 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 565655006140 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 565655006141 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 565655006142 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 565655006143 Walker A/P-loop; other site 565655006144 ATP binding site [chemical binding]; other site 565655006145 Q-loop/lid; other site 565655006146 ABC transporter signature motif; other site 565655006147 Walker B; other site 565655006148 D-loop; other site 565655006149 H-loop/switch region; other site 565655006150 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 565655006151 Histidine kinase; Region: HisKA_3; pfam07730 565655006152 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 565655006153 ATP binding site [chemical binding]; other site 565655006154 Mg2+ binding site [ion binding]; other site 565655006155 G-X-G motif; other site 565655006156 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 565655006157 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 565655006158 active site 565655006159 phosphorylation site [posttranslational modification] 565655006160 intermolecular recognition site; other site 565655006161 dimerization interface [polypeptide binding]; other site 565655006162 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 565655006163 DNA binding residues [nucleotide binding] 565655006164 dimerization interface [polypeptide binding]; other site 565655006165 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 565655006166 AAA domain; Region: AAA_30; pfam13604 565655006167 Family description; Region: UvrD_C_2; pfam13538 565655006168 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 565655006169 catalytic core [active] 565655006170 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 565655006171 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 565655006172 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 565655006173 S-adenosylmethionine binding site [chemical binding]; other site 565655006174 Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142 565655006175 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 565655006176 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 565655006177 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 565655006178 Walker A/P-loop; other site 565655006179 ATP binding site [chemical binding]; other site 565655006180 Q-loop/lid; other site 565655006181 ABC transporter signature motif; other site 565655006182 Walker B; other site 565655006183 D-loop; other site 565655006184 H-loop/switch region; other site 565655006185 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 565655006186 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 565655006187 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 565655006188 Walker A/P-loop; other site 565655006189 ATP binding site [chemical binding]; other site 565655006190 Q-loop/lid; other site 565655006191 ABC transporter signature motif; other site 565655006192 Walker B; other site 565655006193 D-loop; other site 565655006194 H-loop/switch region; other site 565655006195 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 565655006196 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 565655006197 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 565655006198 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 565655006199 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 565655006200 MgtE intracellular N domain; Region: MgtE_N; pfam03448 565655006201 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 565655006202 Divalent cation transporter; Region: MgtE; pfam01769 565655006203 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 565655006204 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 565655006205 active site 565655006206 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 565655006207 ATP-NAD kinase; Region: NAD_kinase; pfam01513 565655006208 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 565655006209 synthetase active site [active] 565655006210 NTP binding site [chemical binding]; other site 565655006211 metal binding site [ion binding]; metal-binding site 565655006212 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 565655006213 putative active site [active] 565655006214 putative metal binding residues [ion binding]; other site 565655006215 signature motif; other site 565655006216 putative triphosphate binding site [ion binding]; other site 565655006217 Thioredoxin; Region: Thioredoxin_5; pfam13743 565655006218 Oligoendopeptidase F [Amino acid transport and metabolism]; Region: COG1164 565655006219 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 565655006220 active site 565655006221 Zn binding site [ion binding]; other site 565655006222 Competence protein CoiA-like family; Region: CoiA; cl11541 565655006223 adaptor protein; Provisional; Region: PRK02315 565655006224 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 565655006225 ArsC family; Region: ArsC; pfam03960 565655006226 putative catalytic residues [active] 565655006227 thiol/disulfide switch; other site 565655006228 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 565655006229 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 565655006230 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 565655006231 Walker A/P-loop; other site 565655006232 ATP binding site [chemical binding]; other site 565655006233 Q-loop/lid; other site 565655006234 ABC transporter signature motif; other site 565655006235 Walker B; other site 565655006236 D-loop; other site 565655006237 H-loop/switch region; other site 565655006238 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 565655006239 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 565655006240 motif II; other site 565655006241 SWIM zinc finger; Region: SWIM; pfam04434 565655006242 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 565655006243 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 565655006244 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 565655006245 ATP binding site [chemical binding]; other site 565655006246 putative Mg++ binding site [ion binding]; other site 565655006247 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 565655006248 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 565655006249 nucleotide binding region [chemical binding]; other site 565655006250 ATP-binding site [chemical binding]; other site 565655006251 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 565655006252 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 565655006253 Walker A/P-loop; other site 565655006254 ATP binding site [chemical binding]; other site 565655006255 Q-loop/lid; other site 565655006256 ABC transporter signature motif; other site 565655006257 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 565655006258 ABC transporter signature motif; other site 565655006259 Walker B; other site 565655006260 D-loop; other site 565655006261 H-loop/switch region; other site 565655006262 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 565655006263 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 565655006264 active site 565655006265 metal binding site [ion binding]; metal-binding site 565655006266 DNA binding site [nucleotide binding] 565655006267 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 565655006268 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 565655006269 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 565655006270 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 565655006271 Uncharacterized conserved protein [Function unknown]; Region: COG3589 565655006272 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 565655006273 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 565655006274 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 565655006275 putative acyl-acceptor binding pocket; other site 565655006276 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 565655006277 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 565655006278 S-adenosylmethionine binding site [chemical binding]; other site 565655006279 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 565655006280 GIY-YIG motif/motif A; other site 565655006281 putative active site [active] 565655006282 putative metal binding site [ion binding]; other site 565655006283 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 565655006284 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915 565655006285 Cl- selectivity filter; other site 565655006286 Cl- binding residues [ion binding]; other site 565655006287 pore gating glutamate residue; other site 565655006288 dimer interface [polypeptide binding]; other site 565655006289 elongation factor P; Validated; Region: PRK00529 565655006290 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 565655006291 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 565655006292 RNA binding site [nucleotide binding]; other site 565655006293 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 565655006294 RNA binding site [nucleotide binding]; other site 565655006295 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 565655006296 Cation efflux family; Region: Cation_efflux; pfam01545 565655006297 hypothetical protein; Provisional; Region: PRK04164 565655006298 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 565655006299 WxL domain surface cell wall-binding; Region: WxL; pfam13731 565655006300 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 565655006301 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 565655006302 homodimer interface [polypeptide binding]; other site 565655006303 active site pocket [active] 565655006304 glycogen synthase; Provisional; Region: glgA; PRK00654 565655006305 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 565655006306 ADP-binding pocket [chemical binding]; other site 565655006307 homodimer interface [polypeptide binding]; other site 565655006308 glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092 565655006309 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 565655006310 active site 565655006311 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 565655006312 dimer interface [polypeptide binding]; other site 565655006313 N-terminal domain interface [polypeptide binding]; other site 565655006314 sulfate 1 binding site; other site 565655006315 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 565655006316 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 565655006317 ligand binding site; other site 565655006318 oligomer interface; other site 565655006319 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 565655006320 dimer interface [polypeptide binding]; other site 565655006321 N-terminal domain interface [polypeptide binding]; other site 565655006322 sulfate 1 binding site; other site 565655006323 glycogen branching enzyme; Provisional; Region: PRK12313 565655006324 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 565655006325 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 565655006326 active site 565655006327 catalytic site [active] 565655006328 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 565655006329 Domain of unknown function (DUF1803); Region: DUF1803; pfam08820 565655006330 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 565655006331 DHH family; Region: DHH; pfam01368 565655006332 DHHA2 domain; Region: DHHA2; pfam02833 565655006333 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 565655006334 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 565655006335 FeS/SAM binding site; other site 565655006336 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 565655006337 Pyruvate formate lyase 1; Region: PFL1; cd01678 565655006338 coenzyme A binding site [chemical binding]; other site 565655006339 active site 565655006340 catalytic residues [active] 565655006341 glycine loop; other site 565655006342 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 565655006343 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 565655006344 CAP-like domain; other site 565655006345 active site 565655006346 primary dimer interface [polypeptide binding]; other site 565655006347 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 565655006348 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 565655006349 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 565655006350 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 565655006351 ATP binding site [chemical binding]; other site 565655006352 Mg2+ binding site [ion binding]; other site 565655006353 G-X-G motif; other site 565655006354 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 565655006355 anchoring element; other site 565655006356 dimer interface [polypeptide binding]; other site 565655006357 ATP binding site [chemical binding]; other site 565655006358 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 565655006359 active site 565655006360 putative metal-binding site [ion binding]; other site 565655006361 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 565655006362 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 565655006363 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 565655006364 active site 565655006365 catalytic residues [active] 565655006366 transcriptional repressor CodY; Validated; Region: PRK04158 565655006367 CodY GAF-like domain; Region: CodY; pfam06018 565655006368 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 565655006369 putative DNA binding site [nucleotide binding]; other site 565655006370 putative Zn2+ binding site [ion binding]; other site 565655006371 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 565655006372 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 565655006373 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 565655006374 Walker A motif; other site 565655006375 ATP binding site [chemical binding]; other site 565655006376 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 565655006377 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 565655006378 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 565655006379 active site 565655006380 HslU subunit interaction site [polypeptide binding]; other site 565655006381 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 565655006382 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 565655006383 active site 565655006384 Int/Topo IB signature motif; other site 565655006385 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 565655006386 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 565655006387 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 565655006388 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 565655006389 Glucose inhibited division protein A; Region: GIDA; pfam01134 565655006390 DNA topoisomerase I; Validated; Region: PRK05582 565655006391 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 565655006392 active site 565655006393 interdomain interaction site; other site 565655006394 putative metal-binding site [ion binding]; other site 565655006395 nucleotide binding site [chemical binding]; other site 565655006396 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 565655006397 domain I; other site 565655006398 DNA binding groove [nucleotide binding] 565655006399 phosphate binding site [ion binding]; other site 565655006400 domain II; other site 565655006401 domain III; other site 565655006402 nucleotide binding site [chemical binding]; other site 565655006403 catalytic site [active] 565655006404 domain IV; other site 565655006405 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 565655006406 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 565655006407 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 565655006408 DNA protecting protein DprA; Region: dprA; TIGR00732 565655006409 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 565655006410 RNA/DNA hybrid binding site [nucleotide binding]; other site 565655006411 active site 565655006412 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 565655006413 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 565655006414 GTP/Mg2+ binding site [chemical binding]; other site 565655006415 G4 box; other site 565655006416 G5 box; other site 565655006417 G1 box; other site 565655006418 Switch I region; other site 565655006419 G2 box; other site 565655006420 G3 box; other site 565655006421 Switch II region; other site 565655006422 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 565655006423 active site 565655006424 catalytic site [active] 565655006425 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 565655006426 Cna protein B-type domain; Region: Cna_B; pfam05738 565655006427 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 565655006428 metal ion-dependent adhesion site (MIDAS); other site 565655006429 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 565655006430 domain interaction interfaces [polypeptide binding]; other site 565655006431 Cna protein B-type domain; Region: Cna_B; pfam05738 565655006432 Cna protein B-type domain; Region: Cna_B; pfam05738 565655006433 Mga helix-turn-helix domain; Region: Mga; pfam05043 565655006434 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 565655006435 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462 565655006436 Catalytic site [active] 565655006437 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 565655006438 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 565655006439 C-terminal peptidase (prc); Region: prc; TIGR00225 565655006440 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 565655006441 protein binding site [polypeptide binding]; other site 565655006442 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 565655006443 Catalytic dyad [active] 565655006444 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 565655006445 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 565655006446 hypothetical protein; Provisional; Region: PRK13672 565655006447 methionine sulfoxide reductase A; Provisional; Region: PRK14054 565655006448 Uncharacterized protein conserved in bacteria (DUF2140); Region: DUF2140; pfam09911 565655006449 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 565655006450 active site 565655006451 oxyanion hole [active] 565655006452 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 565655006453 catalytic triad [active] 565655006454 EDD domain protein, DegV family; Region: DegV; TIGR00762 565655006455 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 565655006456 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 565655006457 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 565655006458 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 565655006459 Transposase; Region: DDE_Tnp_ISL3; pfam01610 565655006460 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 565655006461 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 565655006462 folate binding site [chemical binding]; other site 565655006463 NADP+ binding site [chemical binding]; other site 565655006464 thymidylate synthase; Region: thym_sym; TIGR03284 565655006465 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 565655006466 dimerization interface [polypeptide binding]; other site 565655006467 active site 565655006468 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 565655006469 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 565655006470 Walker A/P-loop; other site 565655006471 ATP binding site [chemical binding]; other site 565655006472 Q-loop/lid; other site 565655006473 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 565655006474 ABC transporter signature motif; other site 565655006475 Walker B; other site 565655006476 D-loop; other site 565655006477 ABC transporter; Region: ABC_tran_2; pfam12848 565655006478 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 565655006479 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 565655006480 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 565655006481 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 565655006482 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 565655006483 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 565655006484 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 565655006485 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 565655006486 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 565655006487 teichoic acids export protein ATP-binding subunit; Provisional; Region: PRK13546 565655006488 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 565655006489 Walker A/P-loop; other site 565655006490 ATP binding site [chemical binding]; other site 565655006491 Q-loop/lid; other site 565655006492 ABC transporter signature motif; other site 565655006493 Walker B; other site 565655006494 D-loop; other site 565655006495 H-loop/switch region; other site 565655006496 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 565655006497 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 565655006498 active site 565655006499 nucleotide binding site [chemical binding]; other site 565655006500 HIGH motif; other site 565655006501 KMSKS motif; other site 565655006502 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 565655006503 DNA-binding site [nucleotide binding]; DNA binding site 565655006504 RNA-binding motif; other site 565655006505 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 565655006506 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 565655006507 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 565655006508 GtrA-like protein; Region: GtrA; pfam04138 565655006509 Predicted membrane protein [Function unknown]; Region: COG2246 565655006510 Protein of unknown function (DUF1189); Region: DUF1189; pfam06691 565655006511 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 565655006512 Phosphoglycerate Dehydrogenase, 2-hydroxyacid dehydrogenase family; Region: PGDH_1; cd12155 565655006513 putative ligand binding site [chemical binding]; other site 565655006514 NAD binding site [chemical binding]; other site 565655006515 catalytic site [active] 565655006516 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 565655006517 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 565655006518 Ligand binding site; other site 565655006519 Putative Catalytic site; other site 565655006520 DXD motif; other site 565655006521 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 565655006522 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 565655006523 TrkA-N domain; Region: TrkA_N; pfam02254 565655006524 TrkA-C domain; Region: TrkA_C; pfam02080 565655006525 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 565655006526 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 565655006527 active site 565655006528 phosphorylation site [posttranslational modification] 565655006529 intermolecular recognition site; other site 565655006530 dimerization interface [polypeptide binding]; other site 565655006531 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 565655006532 DNA binding residues [nucleotide binding] 565655006533 dimerization interface [polypeptide binding]; other site 565655006534 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 565655006535 Histidine kinase; Region: HisKA_3; pfam07730 565655006536 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 565655006537 ATP binding site [chemical binding]; other site 565655006538 Mg2+ binding site [ion binding]; other site 565655006539 G-X-G motif; other site 565655006540 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 565655006541 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 565655006542 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 565655006543 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 565655006544 YceG-like family; Region: YceG; pfam02618 565655006545 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 565655006546 dimerization interface [polypeptide binding]; other site 565655006547 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 565655006548 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 565655006549 putative ADP-binding pocket [chemical binding]; other site 565655006550 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 565655006551 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 565655006552 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 565655006553 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 565655006554 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 565655006555 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 565655006556 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 565655006557 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 565655006558 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 565655006559 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 565655006560 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 565655006561 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 565655006562 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 565655006563 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 565655006564 putative dimer interface [polypeptide binding]; other site 565655006565 putative anticodon binding site; other site 565655006566 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 565655006567 homodimer interface [polypeptide binding]; other site 565655006568 motif 1; other site 565655006569 motif 2; other site 565655006570 active site 565655006571 motif 3; other site 565655006572 aspartate aminotransferase; Provisional; Region: PRK05764 565655006573 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 565655006574 pyridoxal 5'-phosphate binding site [chemical binding]; other site 565655006575 homodimer interface [polypeptide binding]; other site 565655006576 catalytic residue [active] 565655006577 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 565655006578 DnaQ family exonuclease/DinG family helicase, putative; Region: dinG_rel; TIGR01407 565655006579 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 565655006580 active site 565655006581 catalytic site [active] 565655006582 substrate binding site [chemical binding]; other site 565655006583 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 565655006584 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 565655006585 classical (c) SDRs; Region: SDR_c; cd05233 565655006586 NAD(P) binding site [chemical binding]; other site 565655006587 active site 565655006588 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 565655006589 Zn2+ binding site [ion binding]; other site 565655006590 Mg2+ binding site [ion binding]; other site 565655006591 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 565655006592 DNA-binding site [nucleotide binding]; DNA binding site 565655006593 RNA-binding motif; other site 565655006594 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 565655006595 Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527 565655006596 Predicted acetyltransferase involved in intracellular survival and related acetyltransferases [General function prediction only]; Region: Eis; COG4552 565655006597 Domain of unknown function (DUF3284); Region: DUF3284; pfam11687 565655006598 Protein of unknown function (DUF3188); Region: DUF3188; pfam11384 565655006599 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 565655006600 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 565655006601 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 565655006602 active site 565655006603 methionine cluster; other site 565655006604 phosphorylation site [posttranslational modification] 565655006605 metal binding site [ion binding]; metal-binding site 565655006606 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 565655006607 active site 565655006608 P-loop; other site 565655006609 phosphorylation site [posttranslational modification] 565655006610 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 565655006611 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 565655006612 putative DNA binding site [nucleotide binding]; other site 565655006613 putative Zn2+ binding site [ion binding]; other site 565655006614 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 565655006615 Walker A motif; other site 565655006616 ATP binding site [chemical binding]; other site 565655006617 Walker B motif; other site 565655006618 Transcriptional antiterminator [Transcription]; Region: COG3933 565655006619 PRD domain; Region: PRD; pfam00874 565655006620 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 565655006621 active pocket/dimerization site; other site 565655006622 active site 565655006623 phosphorylation site [posttranslational modification] 565655006624 PRD domain; Region: PRD; pfam00874 565655006625 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 565655006626 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 565655006627 ATP binding site [chemical binding]; other site 565655006628 putative Mg++ binding site [ion binding]; other site 565655006629 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 565655006630 nucleotide binding region [chemical binding]; other site 565655006631 ATP-binding site [chemical binding]; other site 565655006632 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 565655006633 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 565655006634 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 565655006635 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 565655006636 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 565655006637 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 565655006638 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 565655006639 Uncharacterized conserved protein [Function unknown]; Region: COG1434 565655006640 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 565655006641 putative active site [active] 565655006642 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 565655006643 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 565655006644 Zn2+ binding site [ion binding]; other site 565655006645 Mg2+ binding site [ion binding]; other site 565655006646 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 565655006647 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 565655006648 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 565655006649 Acylphosphatase; Region: Acylphosphatase; pfam00708 565655006650 OxaA-like protein precursor; Provisional; Region: PRK02463 565655006651 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 565655006652 Membrane transport protein; Region: Mem_trans; pfam03547 565655006653 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 565655006654 non-specific DNA binding site [nucleotide binding]; other site 565655006655 salt bridge; other site 565655006656 sequence-specific DNA binding site [nucleotide binding]; other site 565655006657 DNA polymerase III PolC; Validated; Region: polC; PRK00448 565655006658 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 565655006659 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 565655006660 generic binding surface II; other site 565655006661 generic binding surface I; other site 565655006662 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 565655006663 active site 565655006664 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 565655006665 active site 565655006666 catalytic site [active] 565655006667 substrate binding site [chemical binding]; other site 565655006668 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 565655006669 prolyl-tRNA synthetase; Provisional; Region: PRK09194 565655006670 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 565655006671 dimer interface [polypeptide binding]; other site 565655006672 motif 1; other site 565655006673 active site 565655006674 motif 2; other site 565655006675 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 565655006676 putative deacylase active site [active] 565655006677 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 565655006678 active site 565655006679 motif 3; other site 565655006680 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 565655006681 anticodon binding site; other site 565655006682 RIP metalloprotease RseP; Region: TIGR00054 565655006683 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 565655006684 active site 565655006685 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 565655006686 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 565655006687 protein binding site [polypeptide binding]; other site 565655006688 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 565655006689 putative substrate binding region [chemical binding]; other site 565655006690 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 565655006691 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 565655006692 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14830 565655006693 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 565655006694 catalytic residue [active] 565655006695 putative FPP diphosphate binding site; other site 565655006696 putative FPP binding hydrophobic cleft; other site 565655006697 dimer interface [polypeptide binding]; other site 565655006698 putative IPP diphosphate binding site; other site 565655006699 ribosome recycling factor; Reviewed; Region: frr; PRK00083 565655006700 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 565655006701 hinge region; other site 565655006702 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 565655006703 putative nucleotide binding site [chemical binding]; other site 565655006704 uridine monophosphate binding site [chemical binding]; other site 565655006705 homohexameric interface [polypeptide binding]; other site 565655006706 elongation factor Ts; Provisional; Region: tsf; PRK09377 565655006707 UBA/TS-N domain; Region: UBA; pfam00627 565655006708 Elongation factor TS; Region: EF_TS; pfam00889 565655006709 Elongation factor TS; Region: EF_TS; pfam00889 565655006710 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 565655006711 rRNA interaction site [nucleotide binding]; other site 565655006712 S8 interaction site; other site 565655006713 putative laminin-1 binding site; other site 565655006714 Arginine repressor [Transcription]; Region: ArgR; COG1438 565655006715 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 565655006716 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 565655006717 arginyl-tRNA synthetase; Reviewed; Region: PRK12451 565655006718 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 565655006719 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 565655006720 active site 565655006721 HIGH motif; other site 565655006722 KMSK motif region; other site 565655006723 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 565655006724 tRNA binding surface [nucleotide binding]; other site 565655006725 anticodon binding site; other site 565655006726 ornithine carbamoyltransferase; Validated; Region: PRK02102 565655006727 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 565655006728 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 565655006729 UGMP family protein; Validated; Region: PRK09604 565655006730 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 565655006731 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 565655006732 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 565655006733 Coenzyme A binding pocket [chemical binding]; other site 565655006734 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 565655006735 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 565655006736 Coenzyme A binding pocket [chemical binding]; other site 565655006737 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 565655006738 Glycoprotease family; Region: Peptidase_M22; pfam00814 565655006739 Transcriptional regulators [Transcription]; Region: PurR; COG1609 565655006740 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 565655006741 DNA binding site [nucleotide binding] 565655006742 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 565655006743 putative dimerization interface [polypeptide binding]; other site 565655006744 putative ligand binding site [chemical binding]; other site 565655006745 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 565655006746 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 565655006747 Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744 565655006748 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 565655006749 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 565655006750 NAD binding site [chemical binding]; other site 565655006751 homodimer interface [polypeptide binding]; other site 565655006752 active site 565655006753 substrate binding site [chemical binding]; other site 565655006754 galactokinase; Provisional; Region: PRK05322 565655006755 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 565655006756 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 565655006757 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 565655006758 Protein of unknown function (DUF3042); Region: DUF3042; pfam11240 565655006759 Uncharacterized conserved protein [Function unknown]; Region: COG3189 565655006760 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 565655006761 active site residue [active] 565655006762 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 565655006763 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 565655006764 nucleotide binding site [chemical binding]; other site 565655006765 Bacterial protein of unknown function (DUF910); Region: DUF910; pfam06014 565655006766 Rhomboid family; Region: Rhomboid; pfam01694 565655006767 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 565655006768 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 565655006769 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 565655006770 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 565655006771 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 565655006772 ABC-ATPase subunit interface; other site 565655006773 dimer interface [polypeptide binding]; other site 565655006774 putative PBP binding regions; other site 565655006775 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 565655006776 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 565655006777 ABC-ATPase subunit interface; other site 565655006778 dimer interface [polypeptide binding]; other site 565655006779 putative PBP binding regions; other site 565655006780 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 565655006781 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 565655006782 Walker A/P-loop; other site 565655006783 ATP binding site [chemical binding]; other site 565655006784 Q-loop/lid; other site 565655006785 ABC transporter signature motif; other site 565655006786 Walker B; other site 565655006787 D-loop; other site 565655006788 H-loop/switch region; other site 565655006789 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 565655006790 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 565655006791 intersubunit interface [polypeptide binding]; other site 565655006792 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 565655006793 ABC transporter G family member; Provisional; Region: PLN03140 565655006794 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 565655006795 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 565655006796 active site 565655006797 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 565655006798 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 565655006799 active site 565655006800 metal binding site [ion binding]; metal-binding site 565655006801 DNA polymerase IV; Reviewed; Region: PRK03103 565655006802 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 565655006803 active site 565655006804 DNA binding site [nucleotide binding] 565655006805 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 565655006806 Predicted thioesterase [General function prediction only]; Region: COG5496 565655006807 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 565655006808 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 565655006809 active site 565655006810 NTP binding site [chemical binding]; other site 565655006811 metal binding triad [ion binding]; metal-binding site 565655006812 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 565655006813 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 565655006814 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531 565655006815 homodimer interface [polypeptide binding]; other site 565655006816 metal binding site [ion binding]; metal-binding site 565655006817 Uncharacterized conserved protein [Function unknown]; Region: COG1284 565655006818 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 565655006819 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 565655006820 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 565655006821 hypothetical protein; Provisional; Region: PRK03636 565655006822 UPF0302 domain; Region: UPF0302; pfam08864 565655006823 IDEAL domain; Region: IDEAL; pfam08858 565655006824 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 565655006825 binding surface 565655006826 TPR motif; other site 565655006827 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 565655006828 TPR motif; other site 565655006829 binding surface 565655006830 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 565655006831 Tetratricopeptide repeat; Region: TPR_12; pfam13424 565655006832 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 565655006833 Transposase; Region: DDE_Tnp_ISL3; pfam01610 565655006834 threonine dehydratase; Validated; Region: PRK08639 565655006835 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 565655006836 tetramer interface [polypeptide binding]; other site 565655006837 pyridoxal 5'-phosphate binding site [chemical binding]; other site 565655006838 catalytic residue [active] 565655006839 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 565655006840 ketol-acid reductoisomerase; Provisional; Region: PRK05479 565655006841 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 565655006842 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 565655006843 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 565655006844 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 565655006845 putative valine binding site [chemical binding]; other site 565655006846 dimer interface [polypeptide binding]; other site 565655006847 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 565655006848 acetolactate synthase catalytic subunit; Reviewed; Region: PRK07710 565655006849 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 565655006850 PYR/PP interface [polypeptide binding]; other site 565655006851 dimer interface [polypeptide binding]; other site 565655006852 TPP binding site [chemical binding]; other site 565655006853 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 565655006854 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 565655006855 TPP-binding site [chemical binding]; other site 565655006856 dimer interface [polypeptide binding]; other site 565655006857 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 565655006858 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 565655006859 IHF dimer interface [polypeptide binding]; other site 565655006860 IHF - DNA interface [nucleotide binding]; other site 565655006861 GTP-binding protein Der; Reviewed; Region: PRK00093 565655006862 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 565655006863 G1 box; other site 565655006864 GTP/Mg2+ binding site [chemical binding]; other site 565655006865 Switch I region; other site 565655006866 G2 box; other site 565655006867 Switch II region; other site 565655006868 G3 box; other site 565655006869 G4 box; other site 565655006870 G5 box; other site 565655006871 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 565655006872 G1 box; other site 565655006873 GTP/Mg2+ binding site [chemical binding]; other site 565655006874 Switch I region; other site 565655006875 G2 box; other site 565655006876 G3 box; other site 565655006877 Switch II region; other site 565655006878 G4 box; other site 565655006879 G5 box; other site 565655006880 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 565655006881 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 565655006882 RNA binding site [nucleotide binding]; other site 565655006883 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 565655006884 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 565655006885 RNA binding site [nucleotide binding]; other site 565655006886 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 565655006887 RNA binding site [nucleotide binding]; other site 565655006888 cytidylate kinase; Provisional; Region: cmk; PRK00023 565655006889 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 565655006890 CMP-binding site; other site 565655006891 The sites determining sugar specificity; other site 565655006892 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 565655006893 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 565655006894 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 565655006895 ATP binding site [chemical binding]; other site 565655006896 putative Mg++ binding site [ion binding]; other site 565655006897 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 565655006898 nucleotide binding region [chemical binding]; other site 565655006899 ATP-binding site [chemical binding]; other site 565655006900 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 565655006901 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 565655006902 Predicted membrane protein [Function unknown]; Region: COG3601 565655006903 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 565655006904 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 565655006905 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 565655006906 RNA binding surface [nucleotide binding]; other site 565655006907 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 565655006908 active site 565655006909 segregation and condensation protein B; Reviewed; Region: scpB; PRK00135 565655006910 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 565655006911 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 565655006912 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 565655006913 active site 565655006914 Int/Topo IB signature motif; other site 565655006915 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 565655006916 metal binding site 2 [ion binding]; metal-binding site 565655006917 putative DNA binding helix; other site 565655006918 metal binding site 1 [ion binding]; metal-binding site 565655006919 dimer interface [polypeptide binding]; other site 565655006920 structural Zn2+ binding site [ion binding]; other site 565655006921 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 565655006922 S1 domain; Region: S1_2; pfam13509 565655006923 Predicted membrane protein [Function unknown]; Region: COG4392 565655006924 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 565655006925 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 565655006926 Double zinc ribbon; Region: DZR; pfam12773 565655006927 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 565655006928 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 565655006929 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 565655006930 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 565655006931 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 565655006932 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 565655006933 DNA binding residues [nucleotide binding] 565655006934 DNA primase; Validated; Region: dnaG; PRK05667 565655006935 CHC2 zinc finger; Region: zf-CHC2; pfam01807 565655006936 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 565655006937 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 565655006938 active site 565655006939 metal binding site [ion binding]; metal-binding site 565655006940 interdomain interaction site; other site 565655006941 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 565655006942 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 565655006943 N-acetyl-D-glucosamine binding site [chemical binding]; other site 565655006944 catalytic residue [active] 565655006945 elongation factor Tu; Reviewed; Region: PRK00049 565655006946 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 565655006947 G1 box; other site 565655006948 GEF interaction site [polypeptide binding]; other site 565655006949 GTP/Mg2+ binding site [chemical binding]; other site 565655006950 Switch I region; other site 565655006951 G2 box; other site 565655006952 G3 box; other site 565655006953 Switch II region; other site 565655006954 G4 box; other site 565655006955 G5 box; other site 565655006956 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 565655006957 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 565655006958 Antibiotic Binding Site [chemical binding]; other site 565655006959 Protein of unknown function (DUF1093); Region: DUF1093; cl02185 565655006960 37-kD nucleoid-associated bacterial protein; Region: NA37; pfam04245 565655006961 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 565655006962 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 565655006963 active site 565655006964 catalytic tetrad [active] 565655006965 putative acyltransferase; Provisional; Region: PRK05790 565655006966 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 565655006967 dimer interface [polypeptide binding]; other site 565655006968 active site 565655006969 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 565655006970 homodimer interface [polypeptide binding]; other site 565655006971 catalytic residues [active] 565655006972 NAD binding site [chemical binding]; other site 565655006973 substrate binding pocket [chemical binding]; other site 565655006974 flexible flap; other site 565655006975 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 565655006976 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835 565655006977 dimer interface [polypeptide binding]; other site 565655006978 active site 565655006979 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 565655006980 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 565655006981 zinc binding site [ion binding]; other site 565655006982 putative ligand binding site [chemical binding]; other site 565655006983 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 565655006984 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 565655006985 TM-ABC transporter signature motif; other site 565655006986 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 565655006987 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 565655006988 Walker A/P-loop; other site 565655006989 ATP binding site [chemical binding]; other site 565655006990 Q-loop/lid; other site 565655006991 ABC transporter signature motif; other site 565655006992 Walker B; other site 565655006993 D-loop; other site 565655006994 H-loop/switch region; other site 565655006995 V-type ATP synthase subunit D; Reviewed; Region: PRK00373 565655006996 V-type ATP synthase subunit B; Provisional; Region: PRK04196 565655006997 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 565655006998 V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_B; cd01135 565655006999 Walker A motif homologous position; other site 565655007000 Walker B motif; other site 565655007001 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 565655007002 V-type ATP synthase subunit A; Provisional; Region: PRK04192 565655007003 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 565655007004 V/A-type ATP synthase catalytic subunit A. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_A; cd01134 565655007005 Walker A motif/ATP binding site; other site 565655007006 Walker B motif; other site 565655007007 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 565655007008 ATP synthase (F/14-kDa) subunit; Region: ATP-synt_F; cl00632 565655007009 V-type ATP synthase subunit C; Provisional; Region: PRK01198; cl00660 565655007010 Archaeal/vacuolar-type H+-ATPase subunit C [Energy production and conversion]; Region: NtpC; COG1527 565655007011 Archaeal/vacuolar-type H+-ATPase subunit E [Energy production and conversion]; Region: NtpE; COG1390 565655007012 V-type ATP synthase subunit K; Validated; Region: PRK06558 565655007013 ATP synthase subunit C; Region: ATP-synt_C; pfam00137 565655007014 ATP synthase subunit C; Region: ATP-synt_C; pfam00137 565655007015 V-type ATP synthase subunit I; Validated; Region: PRK05771 565655007016 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 565655007017 arginine deiminase; Provisional; Region: PRK01388 565655007018 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 565655007019 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 565655007020 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 565655007021 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 565655007022 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 565655007023 nucleotide binding site/active site [active] 565655007024 HIT family signature motif; other site 565655007025 catalytic residue [active] 565655007026 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 565655007027 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 565655007028 dimerization interface [polypeptide binding]; other site 565655007029 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 565655007030 dimer interface [polypeptide binding]; other site 565655007031 phosphorylation site [posttranslational modification] 565655007032 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 565655007033 ATP binding site [chemical binding]; other site 565655007034 Mg2+ binding site [ion binding]; other site 565655007035 G-X-G motif; other site 565655007036 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 565655007037 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 565655007038 active site 565655007039 phosphorylation site [posttranslational modification] 565655007040 intermolecular recognition site; other site 565655007041 dimerization interface [polypeptide binding]; other site 565655007042 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 565655007043 DNA binding site [nucleotide binding] 565655007044 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 565655007045 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 565655007046 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 565655007047 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 565655007048 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 565655007049 pyruvate kinase; Provisional; Region: PRK06354 565655007050 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 565655007051 domain interfaces; other site 565655007052 active site 565655007053 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 565655007054 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 565655007055 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 565655007056 active site 565655007057 ADP/pyrophosphate binding site [chemical binding]; other site 565655007058 dimerization interface [polypeptide binding]; other site 565655007059 allosteric effector site; other site 565655007060 fructose-1,6-bisphosphate binding site; other site 565655007061 DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587 565655007062 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 565655007063 active site 565655007064 PHP Thumb interface [polypeptide binding]; other site 565655007065 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 565655007066 generic binding surface II; other site 565655007067 generic binding surface I; other site 565655007068 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 565655007069 drug efflux system protein MdtG; Provisional; Region: PRK09874 565655007070 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 565655007071 putative substrate translocation pore; other site 565655007072 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 565655007073 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 565655007074 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 565655007075 active site 565655007076 motif I; other site 565655007077 motif II; other site 565655007078 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 565655007079 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 565655007080 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 565655007081 active site 565655007082 dimer interface [polypeptide binding]; other site 565655007083 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 565655007084 Ligand Binding Site [chemical binding]; other site 565655007085 Molecular Tunnel; other site 565655007086 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 565655007087 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 565655007088 WHG domain; Region: WHG; pfam13305 565655007089 Uncharacterized conserved protein [Function unknown]; Region: COG2966 565655007090 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 565655007091 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 565655007092 Uncharacterized conserved protein [Function unknown]; Region: COG0398 565655007093 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 565655007094 Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; pfam10110 565655007095 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 565655007096 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579 565655007097 putative active site [active] 565655007098 catalytic site [active] 565655007099 putative metal binding site [ion binding]; other site 565655007100 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 565655007101 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 565655007102 active site 565655007103 dimer interface [polypeptide binding]; other site 565655007104 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 565655007105 dimer interface [polypeptide binding]; other site 565655007106 active site 565655007107 glutamate dehydrogenase; Provisional; Region: PRK09414 565655007108 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 565655007109 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 565655007110 NAD(P) binding site [chemical binding]; other site 565655007111 HI0933-like protein; Region: HI0933_like; pfam03486 565655007112 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 565655007113 Class I aldolases; Region: Aldolase_Class_I; cl17187 565655007114 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 565655007115 putative deacylase active site [active] 565655007116 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 565655007117 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 565655007118 active site 565655007119 catalytic residue [active] 565655007120 dimer interface [polypeptide binding]; other site 565655007121 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 565655007122 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 565655007123 putative RNA binding site [nucleotide binding]; other site 565655007124 Methyltransferase domain; Region: Methyltransf_26; pfam13659 565655007125 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 565655007126 Sulfatase; Region: Sulfatase; pfam00884 565655007127 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 565655007128 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 565655007129 dimerization interface [polypeptide binding]; other site 565655007130 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 565655007131 dimer interface [polypeptide binding]; other site 565655007132 phosphorylation site [posttranslational modification] 565655007133 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 565655007134 ATP binding site [chemical binding]; other site 565655007135 Mg2+ binding site [ion binding]; other site 565655007136 G-X-G motif; other site 565655007137 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 565655007138 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 565655007139 active site 565655007140 phosphorylation site [posttranslational modification] 565655007141 intermolecular recognition site; other site 565655007142 dimerization interface [polypeptide binding]; other site 565655007143 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 565655007144 DNA binding site [nucleotide binding] 565655007145 SdpI/YhfL protein family; Region: SdpI; pfam13630 565655007146 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 565655007147 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 565655007148 motif II; other site 565655007149 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 565655007150 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 565655007151 trimer interface [polypeptide binding]; other site 565655007152 active site 565655007153 CoA binding site [chemical binding]; other site 565655007154 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 565655007155 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 565655007156 active site pocket [active] 565655007157 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 565655007158 beta-galactosidase; Region: BGL; TIGR03356 565655007159 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 565655007160 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 565655007161 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 565655007162 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 565655007163 DNA-binding site [nucleotide binding]; DNA binding site 565655007164 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 565655007165 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 565655007166 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 565655007167 NlpC/P60 family; Region: NLPC_P60; pfam00877 565655007168 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 565655007169 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 565655007170 active site 565655007171 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 565655007172 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 565655007173 peptide binding site [polypeptide binding]; other site 565655007174 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 565655007175 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 565655007176 GAF domain; Region: GAF_2; pfam13185 565655007177 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 565655007178 NADH(P)-binding; Region: NAD_binding_10; pfam13460 565655007179 NAD binding site [chemical binding]; other site 565655007180 putative active site [active] 565655007181 substrate binding site [chemical binding]; other site 565655007182 Predicted transcriptional regulator [Transcription]; Region: COG1959 565655007183 Transcriptional regulator; Region: Rrf2; pfam02082 565655007184 Transcriptional regulator; Region: Rrf2; cl17282 565655007185 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 565655007186 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 565655007187 PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; pfam03829 565655007188 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 565655007189 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 565655007190 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 565655007191 Phosphotransferase system sorbitol-specific component IIBC [Carbohydrate transport and metabolism]; Region: SrlE; COG3732 565655007192 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 565655007193 Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663 565655007194 PTS system enzyme II sorbitol-specific factor; Region: EII-GUT; pfam03608 565655007195 Glucitol operon activator protein (GutM); Region: GutM; cl01890 565655007196 Predicted homoserine dehydrogenase [Amino acid transport and metabolism]; Region: COG4091 565655007197 SAF domain of putative dehydrogenases or oxidoreductases; Region: SAF_DH_OX_like; cd11616 565655007198 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH3; cd08287 565655007199 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 565655007200 catalytic Zn binding site [ion binding]; other site 565655007201 NAD(P) binding site [chemical binding]; other site 565655007202 structural Zn binding site [ion binding]; other site 565655007203 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 565655007204 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 565655007205 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 565655007206 RimM N-terminal domain; Region: RimM; pfam01782 565655007207 PRC-barrel domain; Region: PRC; pfam05239 565655007208 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 565655007209 KH domain; Region: KH_4; pfam13083 565655007210 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 565655007211 Predicted flavoprotein [General function prediction only]; Region: COG0431 565655007212 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 565655007213 RibD C-terminal domain; Region: RibD_C; cl17279 565655007214 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 565655007215 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 565655007216 Predicted transcriptional regulators [Transcription]; Region: COG1725 565655007217 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 565655007218 DNA-binding site [nucleotide binding]; DNA binding site 565655007219 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 565655007220 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 565655007221 Walker A/P-loop; other site 565655007222 ATP binding site [chemical binding]; other site 565655007223 Q-loop/lid; other site 565655007224 ABC transporter signature motif; other site 565655007225 Walker B; other site 565655007226 D-loop; other site 565655007227 H-loop/switch region; other site 565655007228 CsbD-like; Region: CsbD; cl17424 565655007229 signal recognition particle protein; Provisional; Region: PRK10867 565655007230 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 565655007231 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 565655007232 P loop; other site 565655007233 GTP binding site [chemical binding]; other site 565655007234 Signal peptide binding domain; Region: SRP_SPB; pfam02978 565655007235 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 565655007236 putative DNA-binding protein; Validated; Region: PRK00118 565655007237 Uncharacterized conserved protein [Function unknown]; Region: COG1683 565655007238 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 565655007239 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 565655007240 active site 565655007241 phosphorylation site [posttranslational modification] 565655007242 intermolecular recognition site; other site 565655007243 dimerization interface [polypeptide binding]; other site 565655007244 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 565655007245 DNA binding site [nucleotide binding] 565655007246 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 565655007247 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 565655007248 dimer interface [polypeptide binding]; other site 565655007249 phosphorylation site [posttranslational modification] 565655007250 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 565655007251 ATP binding site [chemical binding]; other site 565655007252 Mg2+ binding site [ion binding]; other site 565655007253 G-X-G motif; other site 565655007254 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 565655007255 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 565655007256 active site 565655007257 PBP superfamily domain; Region: PBP_like_2; cl17296 565655007258 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 565655007259 aromatic amino acid aminotransferase; Validated; Region: PRK07309 565655007260 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 565655007261 pyridoxal 5'-phosphate binding site [chemical binding]; other site 565655007262 homodimer interface [polypeptide binding]; other site 565655007263 catalytic residue [active] 565655007264 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 565655007265 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 565655007266 DNA binding residues [nucleotide binding] 565655007267 Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; pfam09860 565655007268 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 565655007269 Copper resistance protein B precursor (CopB); Region: CopB; cl01476 565655007270 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 565655007271 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 565655007272 Soluble P-type ATPase [General function prediction only]; Region: COG4087 565655007273 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 565655007274 metal-binding site [ion binding] 565655007275 copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698 565655007276 Penicillinase repressor; Region: Pencillinase_R; pfam03965 565655007277 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 565655007278 active site 565655007279 catalytic residues [active] 565655007280 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 565655007281 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 565655007282 Mg++ binding site [ion binding]; other site 565655007283 putative catalytic motif [active] 565655007284 substrate binding site [chemical binding]; other site 565655007285 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 565655007286 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 565655007287 active site 565655007288 flavodoxin; Validated; Region: PRK07308 565655007289 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 565655007290 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 565655007291 WHG domain; Region: WHG; pfam13305 565655007292 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 565655007293 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 565655007294 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 565655007295 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 565655007296 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 565655007297 FeoA domain; Region: FeoA; pfam04023 565655007298 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 565655007299 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 565655007300 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 565655007301 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 565655007302 dimer interface [polypeptide binding]; other site 565655007303 substrate binding site [chemical binding]; other site 565655007304 ATP binding site [chemical binding]; other site 565655007305 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; pfam07155 565655007306 hypothetical protein; Provisional; Region: PRK13690 565655007307 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 565655007308 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 565655007309 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 565655007310 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 565655007311 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 565655007312 Acyltransferase family; Region: Acyl_transf_3; pfam01757 565655007313 alanine racemase; Reviewed; Region: alr; PRK00053 565655007314 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, VanT and similar proteins; Region: PLPDE_III_VanT; cd06825 565655007315 active site 565655007316 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 565655007317 dimer interface [polypeptide binding]; other site 565655007318 substrate binding site [chemical binding]; other site 565655007319 catalytic residues [active] 565655007320 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 565655007321 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 565655007322 active site 565655007323 phosphorylation site [posttranslational modification] 565655007324 intermolecular recognition site; other site 565655007325 dimerization interface [polypeptide binding]; other site 565655007326 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 565655007327 DNA binding site [nucleotide binding] 565655007328 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 565655007329 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 565655007330 dimer interface [polypeptide binding]; other site 565655007331 phosphorylation site [posttranslational modification] 565655007332 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 565655007333 ATP binding site [chemical binding]; other site 565655007334 Mg2+ binding site [ion binding]; other site 565655007335 G-X-G motif; other site 565655007336 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 565655007337 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 565655007338 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 565655007339 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 565655007340 active site 565655007341 dimer interface [polypeptide binding]; other site 565655007342 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 565655007343 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 565655007344 active site 565655007345 FMN binding site [chemical binding]; other site 565655007346 substrate binding site [chemical binding]; other site 565655007347 3Fe-4S cluster binding site [ion binding]; other site 565655007348 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 565655007349 domain interface; other site 565655007350 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 565655007351 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 565655007352 active site 565655007353 HIGH motif; other site 565655007354 nucleotide binding site [chemical binding]; other site 565655007355 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 565655007356 active site 565655007357 KMSKS motif; other site 565655007358 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 565655007359 tRNA binding surface [nucleotide binding]; other site 565655007360 anticodon binding site; other site 565655007361 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 565655007362 DivIVA protein; Region: DivIVA; pfam05103 565655007363 DivIVA domain; Region: DivI1A_domain; TIGR03544 565655007364 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 565655007365 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 565655007366 RNA binding surface [nucleotide binding]; other site 565655007367 YGGT family; Region: YGGT; pfam02325 565655007368 Protein of unknown function (DUF552); Region: DUF552; pfam04472 565655007369 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 565655007370 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 565655007371 catalytic residue [active] 565655007372 cell division protein FtsZ; Validated; Region: PRK09330 565655007373 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 565655007374 nucleotide binding site [chemical binding]; other site 565655007375 SulA interaction site; other site 565655007376 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 565655007377 Cell division protein FtsA; Region: FtsA; smart00842 565655007378 Cell division protein FtsA; Region: FtsA; pfam14450 565655007379 Domain of unknown function (DUF3484); Region: DUF3484; pfam11983 565655007380 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 565655007381 Cell division protein FtsQ; Region: FtsQ; pfam03799 565655007382 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 565655007383 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 565655007384 active site 565655007385 homodimer interface [polypeptide binding]; other site 565655007386 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002 565655007387 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 565655007388 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 565655007389 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 565655007390 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 565655007391 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 565655007392 Mg++ binding site [ion binding]; other site 565655007393 putative catalytic motif [active] 565655007394 putative substrate binding site [chemical binding]; other site 565655007395 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 565655007396 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 565655007397 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 565655007398 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 565655007399 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 565655007400 Cell division protein FtsL; Region: FtsL; cl11433 565655007401 MraW methylase family; Region: Methyltransf_5; pfam01795 565655007402 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 565655007403 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001 565655007404 MraZ protein; Region: MraZ; pfam02381 565655007405 MraZ protein; Region: MraZ; pfam02381 565655007406 Protein of unknown function (DUF3397); Region: DUF3397; pfam11877 565655007407 Protein of unknown function (DUF4044); Region: DUF4044; pfam13253 565655007408 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 565655007409 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 565655007410 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 565655007411 putative active site [active] 565655007412 catalytic site [active] 565655007413 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 565655007414 putative active site [active] 565655007415 catalytic site [active] 565655007416 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 565655007417 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 565655007418 FtsX-like permease family; Region: FtsX; pfam02687 565655007419 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 565655007420 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 565655007421 Walker A/P-loop; other site 565655007422 ATP binding site [chemical binding]; other site 565655007423 Q-loop/lid; other site 565655007424 ABC transporter signature motif; other site 565655007425 Walker B; other site 565655007426 D-loop; other site 565655007427 H-loop/switch region; other site 565655007428 This domain is found in peptide chain release factors; Region: PCRF; smart00937 565655007429 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 565655007430 RF-1 domain; Region: RF-1; pfam00472 565655007431 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 565655007432 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 565655007433 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 565655007434 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 565655007435 nucleotide binding region [chemical binding]; other site 565655007436 ATP-binding site [chemical binding]; other site 565655007437 SEC-C motif; Region: SEC-C; pfam02810 565655007438 Predicted integral membrane protein [Function unknown]; Region: COG5521 565655007439 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 565655007440 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 565655007441 dimer interface [polypeptide binding]; other site 565655007442 conserved gate region; other site 565655007443 putative PBP binding loops; other site 565655007444 ABC-ATPase subunit interface; other site 565655007445 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 565655007446 dimer interface [polypeptide binding]; other site 565655007447 conserved gate region; other site 565655007448 putative PBP binding loops; other site 565655007449 ABC-ATPase subunit interface; other site 565655007450 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 565655007451 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 565655007452 Transcriptional regulators [Transcription]; Region: PurR; COG1609 565655007453 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 565655007454 DNA binding site [nucleotide binding] 565655007455 domain linker motif; other site 565655007456 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 565655007457 ligand binding site [chemical binding]; other site 565655007458 dimerization interface [polypeptide binding]; other site 565655007459 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 565655007460 30S subunit binding site; other site 565655007461 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 565655007462 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 565655007463 active site 565655007464 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 565655007465 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 565655007466 ATP binding site [chemical binding]; other site 565655007467 putative Mg++ binding site [ion binding]; other site 565655007468 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 565655007469 nucleotide binding region [chemical binding]; other site 565655007470 ATP-binding site [chemical binding]; other site 565655007471 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 565655007472 active site 565655007473 P-loop; other site 565655007474 phosphorylation site [posttranslational modification] 565655007475 Uncharacterized conserved protein [Function unknown]; Region: COG1739 565655007476 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 565655007477 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 565655007478 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 565655007479 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 565655007480 DNA-binding site [nucleotide binding]; DNA binding site 565655007481 UTRA domain; Region: UTRA; pfam07702 565655007482 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 565655007483 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 565655007484 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 565655007485 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3580 565655007486 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 565655007487 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 565655007488 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 565655007489 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 565655007490 Protein of unknown function (DUF2969); Region: DUF2969; pfam11184 565655007491 FOG: CBS domain [General function prediction only]; Region: COG0517 565655007492 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms. They produce...; Region: CBS_pair_ACT_assoc2; cd04585 565655007493 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 565655007494 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 565655007495 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 565655007496 Walker A/P-loop; other site 565655007497 ATP binding site [chemical binding]; other site 565655007498 Q-loop/lid; other site 565655007499 ABC transporter signature motif; other site 565655007500 Walker B; other site 565655007501 D-loop; other site 565655007502 H-loop/switch region; other site 565655007503 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 565655007504 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 565655007505 Walker A/P-loop; other site 565655007506 ATP binding site [chemical binding]; other site 565655007507 Q-loop/lid; other site 565655007508 ABC transporter signature motif; other site 565655007509 Walker B; other site 565655007510 D-loop; other site 565655007511 H-loop/switch region; other site 565655007512 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 565655007513 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 565655007514 TM-ABC transporter signature motif; other site 565655007515 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 565655007516 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 565655007517 TM-ABC transporter signature motif; other site 565655007518 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 565655007519 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347 565655007520 putative ligand binding site [chemical binding]; other site 565655007521 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 565655007522 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 565655007523 nucleotide binding site [chemical binding]; other site 565655007524 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 565655007525 Coenzyme A binding pocket [chemical binding]; other site 565655007526 Haemolytic domain; Region: Haemolytic; pfam01809 565655007527 DNA-directed RNA polymerase subunit beta; Region: EpuA; pfam11772 565655007528 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 565655007529 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 565655007530 hinge; other site 565655007531 active site 565655007532 conserved hypothetical integral membrane protein; Region: int_mem_ywzB; TIGR02327 565655007533 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 565655007534 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 565655007535 gamma subunit interface [polypeptide binding]; other site 565655007536 epsilon subunit interface [polypeptide binding]; other site 565655007537 LBP interface [polypeptide binding]; other site 565655007538 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 565655007539 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 565655007540 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 565655007541 alpha subunit interaction interface [polypeptide binding]; other site 565655007542 Walker A motif; other site 565655007543 ATP binding site [chemical binding]; other site 565655007544 Walker B motif; other site 565655007545 inhibitor binding site; inhibition site 565655007546 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 565655007547 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 565655007548 core domain interface [polypeptide binding]; other site 565655007549 delta subunit interface [polypeptide binding]; other site 565655007550 epsilon subunit interface [polypeptide binding]; other site 565655007551 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 565655007552 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 565655007553 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 565655007554 beta subunit interaction interface [polypeptide binding]; other site 565655007555 Walker A motif; other site 565655007556 ATP binding site [chemical binding]; other site 565655007557 Walker B motif; other site 565655007558 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 565655007559 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 565655007560 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 565655007561 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 565655007562 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 565655007563 ATP synthase, F0 subunit c; Region: ATP_synt_c; TIGR01260 565655007564 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 565655007565 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 565655007566 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 565655007567 SmpB-tmRNA interface; other site 565655007568 ribonuclease R; Region: RNase_R; TIGR02063 565655007569 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 565655007570 RNB domain; Region: RNB; pfam00773 565655007571 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 565655007572 RNA binding site [nucleotide binding]; other site 565655007573 Esterase/lipase [General function prediction only]; Region: COG1647 565655007574 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 565655007575 Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314 565655007576 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 565655007577 Coenzyme A binding pocket [chemical binding]; other site 565655007578 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 565655007579 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 565655007580 Cna protein B-type domain; Region: Cna_B; pfam05738 565655007581 choice-of-anchor A domain; Region: choice_anch_A; TIGR04215 565655007582 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 565655007583 domain interaction interfaces [polypeptide binding]; other site 565655007584 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 565655007585 domain interaction interfaces [polypeptide binding]; other site 565655007586 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 565655007587 domain interaction interfaces [polypeptide binding]; other site 565655007588 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 565655007589 domain interaction interfaces [polypeptide binding]; other site 565655007590 enolase; Provisional; Region: eno; PRK00077 565655007591 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 565655007592 dimer interface [polypeptide binding]; other site 565655007593 metal binding site [ion binding]; metal-binding site 565655007594 substrate binding pocket [chemical binding]; other site 565655007595 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 565655007596 triosephosphate isomerase; Provisional; Region: PRK14565 565655007597 substrate binding site [chemical binding]; other site 565655007598 dimer interface [polypeptide binding]; other site 565655007599 catalytic triad [active] 565655007600 Phosphoglycerate kinase; Region: PGK; pfam00162 565655007601 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 565655007602 substrate binding site [chemical binding]; other site 565655007603 hinge regions; other site 565655007604 ADP binding site [chemical binding]; other site 565655007605 catalytic site [active] 565655007606 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 565655007607 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 565655007608 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 565655007609 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 565655007610 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 565655007611 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 565655007612 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 565655007613 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 565655007614 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 565655007615 DNA binding site [nucleotide binding] 565655007616 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066 565655007617 Domain of unknown function (DUF1934); Region: DUF1934; pfam09148 565655007618 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 565655007619 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 565655007620 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 565655007621 Zn2+ binding site [ion binding]; other site 565655007622 Mg2+ binding site [ion binding]; other site 565655007623 sugar phosphate phosphatase; Provisional; Region: PRK10513 565655007624 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 565655007625 active site 565655007626 motif I; other site 565655007627 motif II; other site 565655007628 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 565655007629 Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684 565655007630 nudix motif; other site 565655007631 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 565655007632 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 565655007633 dimer interface [polypeptide binding]; other site 565655007634 active site 565655007635 metal binding site [ion binding]; metal-binding site 565655007636 glutathione binding site [chemical binding]; other site 565655007637 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 565655007638 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 565655007639 catalytic triad [active] 565655007640 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 565655007641 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 565655007642 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 565655007643 Walker A/P-loop; other site 565655007644 ATP binding site [chemical binding]; other site 565655007645 Q-loop/lid; other site 565655007646 ABC transporter signature motif; other site 565655007647 Walker B; other site 565655007648 D-loop; other site 565655007649 H-loop/switch region; other site 565655007650 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 565655007651 Protein of unknown function (DUF2812); Region: DUF2812; pfam11193 565655007652 Predicted transcriptional regulators [Transcription]; Region: COG1695 565655007653 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 565655007654 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 565655007655 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 565655007656 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 565655007657 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 565655007658 catalytic residues [active] 565655007659 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 565655007660 MutS domain III; Region: MutS_III; pfam05192 565655007661 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 565655007662 Walker A/P-loop; other site 565655007663 ATP binding site [chemical binding]; other site 565655007664 Q-loop/lid; other site 565655007665 ABC transporter signature motif; other site 565655007666 Walker B; other site 565655007667 D-loop; other site 565655007668 H-loop/switch region; other site 565655007669 Smr domain; Region: Smr; pfam01713 565655007670 Colicin V production protein; Region: Colicin_V; pfam02674 565655007671 Cell division protein ZapA; Region: ZapA; cl01146 565655007672 ribonuclease HIII; Provisional; Region: PRK00996 565655007673 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 565655007674 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 565655007675 RNA/DNA hybrid binding site [nucleotide binding]; other site 565655007676 active site 565655007677 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 565655007678 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 565655007679 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_3; cd07241 565655007680 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 565655007681 putative metal binding site [ion binding]; other site 565655007682 maltose O-acetyltransferase; Provisional; Region: PRK10092 565655007683 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 565655007684 active site 565655007685 substrate binding site [chemical binding]; other site 565655007686 trimer interface [polypeptide binding]; other site 565655007687 CoA binding site [chemical binding]; other site 565655007688 histidinol phosphate phosphatase, HisJ family; Region: hisJ_fam; TIGR01856 565655007689 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 565655007690 active site 565655007691 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 565655007692 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 565655007693 dimer interface [polypeptide binding]; other site 565655007694 conserved gate region; other site 565655007695 putative PBP binding loops; other site 565655007696 ABC-ATPase subunit interface; other site 565655007697 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 565655007698 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 565655007699 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 565655007700 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 565655007701 Walker A/P-loop; other site 565655007702 ATP binding site [chemical binding]; other site 565655007703 Q-loop/lid; other site 565655007704 ABC transporter signature motif; other site 565655007705 Walker B; other site 565655007706 D-loop; other site 565655007707 H-loop/switch region; other site 565655007708 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 565655007709 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 565655007710 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 565655007711 DNA-binding site [nucleotide binding]; DNA binding site 565655007712 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 565655007713 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain; Region: 2-Hacid_dh; pfam00389 565655007714 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 565655007715 NAD binding site [chemical binding]; other site 565655007716 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 565655007717 phosphonate metabolim protein, transferase hexapeptide repeat family; Region: phn_thr-fam; TIGR03308 565655007718 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 565655007719 trimer interface [polypeptide binding]; other site 565655007720 active site 565655007721 substrate binding site [chemical binding]; other site 565655007722 CoA binding site [chemical binding]; other site 565655007723 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 565655007724 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 565655007725 acyl-activating enzyme (AAE) consensus motif; other site 565655007726 active site 565655007727 AMP binding site [chemical binding]; other site 565655007728 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 565655007729 N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317 565655007730 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 565655007731 active site 565655007732 octamer interface [polypeptide binding]; other site 565655007733 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 565655007734 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 565655007735 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 565655007736 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 565655007737 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 565655007738 dimer interface [polypeptide binding]; other site 565655007739 tetramer interface [polypeptide binding]; other site 565655007740 PYR/PP interface [polypeptide binding]; other site 565655007741 TPP binding site [chemical binding]; other site 565655007742 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 565655007743 TPP-binding site; other site 565655007744 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 565655007745 chorismate binding enzyme; Region: Chorismate_bind; cl10555 565655007746 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK03640 565655007747 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 565655007748 acyl-activating enzyme (AAE) consensus motif; other site 565655007749 putative AMP binding site [chemical binding]; other site 565655007750 putative active site [active] 565655007751 putative CoA binding site [chemical binding]; other site 565655007752 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 565655007753 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 565655007754 substrate binding site [chemical binding]; other site 565655007755 oxyanion hole (OAH) forming residues; other site 565655007756 trimer interface [polypeptide binding]; other site 565655007757 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 565655007758 CoenzymeA binding site [chemical binding]; other site 565655007759 subunit interaction site [polypeptide binding]; other site 565655007760 PHB binding site; other site 565655007761 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 565655007762 Domain of unknown function DUF20; Region: UPF0118; pfam01594 565655007763 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 565655007764 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 565655007765 nucleotide binding site [chemical binding]; other site 565655007766 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 565655007767 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 565655007768 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 565655007769 dimer interface [polypeptide binding]; other site 565655007770 conserved gate region; other site 565655007771 putative PBP binding loops; other site 565655007772 ABC-ATPase subunit interface; other site 565655007773 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 565655007774 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 565655007775 substrate binding pocket [chemical binding]; other site 565655007776 membrane-bound complex binding site; other site 565655007777 hinge residues; other site 565655007778 amidase; Provisional; Region: PRK06529 565655007779 Amidase; Region: Amidase; cl11426 565655007780 Predicted membrane protein [Function unknown]; Region: COG2035 565655007781 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 565655007782 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 565655007783 Coenzyme A binding pocket [chemical binding]; other site 565655007784 Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488 565655007785 L-lactate oxidase; Region: L_lactate_ox; TIGR02708 565655007786 L-Lactate oxidase (LOX) FMN-binding domain. LOX is a member of the family of FMN-containing alpha-hydroxyacid oxidases and catalyzes the oxidation of l-lactate using molecular oxygen to generate pyruvate and H2O2. This family occurs in both prokaryotes...; Region: LOX_like_FMN; cd04737 565655007787 teramer interface [polypeptide binding]; other site 565655007788 active site 565655007789 FMN binding site [chemical binding]; other site 565655007790 catalytic residues [active] 565655007791 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 565655007792 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 565655007793 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 565655007794 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 565655007795 substrate binding site [chemical binding]; other site 565655007796 hexamer interface [polypeptide binding]; other site 565655007797 metal binding site [ion binding]; metal-binding site 565655007798 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 565655007799 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 565655007800 motif II; other site 565655007801 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 565655007802 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 565655007803 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 565655007804 PTS system mannitol-specific transporter subunit IICBA; Provisional; Region: PRK15083 565655007805 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 565655007806 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 565655007807 active site 565655007808 P-loop; other site 565655007809 phosphorylation site [posttranslational modification] 565655007810 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 565655007811 active site 565655007812 phosphorylation site [posttranslational modification] 565655007813 sorbitol-6-phosphate 2-dehydrogenase; Provisional; Region: PRK06171 565655007814 classical (c) SDRs; Region: SDR_c; cd05233 565655007815 NAD(P) binding site [chemical binding]; other site 565655007816 active site 565655007817 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 565655007818 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 565655007819 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 565655007820 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 565655007821 nudix motif; other site 565655007822 hypothetical protein; Provisional; Region: PRK13678 565655007823 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 565655007824 hypothetical protein; Provisional; Region: PRK05473 565655007825 Domain of unknown function (DUF1980); Region: DUF1980; cl01492 565655007826 Predicted permeases [General function prediction only]; Region: COG0701 565655007827 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 565655007828 catalytic residues [active] 565655007829 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 565655007830 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 565655007831 CoA binding domain; Region: CoA_binding; pfam02629 565655007832 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 565655007833 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 565655007834 Walker A/P-loop; other site 565655007835 ATP binding site [chemical binding]; other site 565655007836 Q-loop/lid; other site 565655007837 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 565655007838 ABC transporter signature motif; other site 565655007839 Walker B; other site 565655007840 D-loop; other site 565655007841 ABC transporter; Region: ABC_tran_2; pfam12848 565655007842 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 565655007843 putative active site [active] 565655007844 Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529 565655007845 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 565655007846 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 565655007847 hexamer interface [polypeptide binding]; other site 565655007848 ligand binding site [chemical binding]; other site 565655007849 putative active site [active] 565655007850 NAD(P) binding site [chemical binding]; other site 565655007851 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 565655007852 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 565655007853 active site 565655007854 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 565655007855 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 565655007856 dimer interface [polypeptide binding]; other site 565655007857 conserved gate region; other site 565655007858 putative PBP binding loops; other site 565655007859 ABC-ATPase subunit interface; other site 565655007860 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 565655007861 dimer interface [polypeptide binding]; other site 565655007862 conserved gate region; other site 565655007863 putative PBP binding loops; other site 565655007864 ABC-ATPase subunit interface; other site 565655007865 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 565655007866 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 565655007867 Walker A/P-loop; other site 565655007868 ATP binding site [chemical binding]; other site 565655007869 Q-loop/lid; other site 565655007870 ABC transporter signature motif; other site 565655007871 Walker B; other site 565655007872 D-loop; other site 565655007873 H-loop/switch region; other site 565655007874 TOBE domain; Region: TOBE_2; pfam08402 565655007875 2-aminoethylphosphonate ABC transporter substrate-binding protein; Provisional; Region: PRK15046 565655007876 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 565655007877 Response regulator receiver domain; Region: Response_reg; pfam00072 565655007878 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 565655007879 active site 565655007880 phosphorylation site [posttranslational modification] 565655007881 intermolecular recognition site; other site 565655007882 dimerization interface [polypeptide binding]; other site 565655007883 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 565655007884 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 565655007885 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 565655007886 HAMP domain; Region: HAMP; pfam00672 565655007887 dimerization interface [polypeptide binding]; other site 565655007888 Histidine kinase; Region: His_kinase; pfam06580 565655007889 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 565655007890 Mg2+ binding site [ion binding]; other site 565655007891 G-X-G motif; other site 565655007892 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 565655007893 Major Facilitator Superfamily; Region: MFS_1; pfam07690 565655007894 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK12315 565655007895 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 565655007896 TPP-binding site; other site 565655007897 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 565655007898 PYR/PP interface [polypeptide binding]; other site 565655007899 dimer interface [polypeptide binding]; other site 565655007900 TPP binding site [chemical binding]; other site 565655007901 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 565655007902 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 565655007903 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 565655007904 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 565655007905 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 565655007906 dimer interface [polypeptide binding]; other site 565655007907 conserved gate region; other site 565655007908 putative PBP binding loops; other site 565655007909 ABC-ATPase subunit interface; other site 565655007910 2-aminoethylphosphonate transport system permease PhnU; Provisional; Region: PRK15050 565655007911 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 565655007912 dimer interface [polypeptide binding]; other site 565655007913 conserved gate region; other site 565655007914 putative PBP binding loops; other site 565655007915 ABC-ATPase subunit interface; other site 565655007916 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 565655007917 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 565655007918 Walker A/P-loop; other site 565655007919 ATP binding site [chemical binding]; other site 565655007920 Q-loop/lid; other site 565655007921 ABC transporter signature motif; other site 565655007922 Walker B; other site 565655007923 D-loop; other site 565655007924 H-loop/switch region; other site 565655007925 TOBE domain; Region: TOBE_2; pfam08402 565655007926 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 565655007927 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 565655007928 non-specific DNA binding site [nucleotide binding]; other site 565655007929 salt bridge; other site 565655007930 sequence-specific DNA binding site [nucleotide binding]; other site 565655007931 Cupin domain; Region: Cupin_2; pfam07883 565655007932 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 565655007933 Yhdh and yhfp-like putative quinone oxidoreductases; Region: MDR_yhdh_yhfp; cd05280 565655007934 NADP binding site [chemical binding]; other site 565655007935 dimer interface [polypeptide binding]; other site 565655007936 DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410 565655007937 phosphopantothenoylcysteine decarboxylase; Validated; Region: PRK07313 565655007938 Flavoprotein; Region: Flavoprotein; pfam02441 565655007939 Predicted membrane protein [Function unknown]; Region: COG4684 565655007940 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 565655007941 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 565655007942 FAD binding domain; Region: FAD_binding_4; pfam01565 565655007943 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 565655007944 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 565655007945 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 565655007946 active site 565655007947 putative catalytic site [active] 565655007948 DNA binding site [nucleotide binding] 565655007949 putative phosphate binding site [ion binding]; other site 565655007950 metal binding site A [ion binding]; metal-binding site 565655007951 AP binding site [nucleotide binding]; other site 565655007952 metal binding site B [ion binding]; metal-binding site 565655007953 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 565655007954 active site 565655007955 catalytic site [active] 565655007956 substrate binding site [chemical binding]; other site 565655007957 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 565655007958 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 565655007959 Coenzyme A binding pocket [chemical binding]; other site 565655007960 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 565655007961 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 565655007962 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 565655007963 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 565655007964 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 565655007965 ligand binding site [chemical binding]; other site 565655007966 active site 565655007967 UGI interface [polypeptide binding]; other site 565655007968 catalytic site [active] 565655007969 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 565655007970 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 565655007971 active site 565655007972 motif I; other site 565655007973 motif II; other site 565655007974 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 565655007975 Tubby C 2; Region: Tub_2; cl02043 565655007976 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 565655007977 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 565655007978 Coenzyme A binding pocket [chemical binding]; other site 565655007979 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 565655007980 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 565655007981 putative metal binding site [ion binding]; other site 565655007982 NrdI Flavodoxin like; Region: Flavodoxin_NdrI; cl17293 565655007983 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 565655007984 Walker A/P-loop; other site 565655007985 ATP binding site [chemical binding]; other site 565655007986 Q-loop/lid; other site 565655007987 ABC transporter signature motif; other site 565655007988 Walker B; other site 565655007989 D-loop; other site 565655007990 H-loop/switch region; other site 565655007991 Sulfatase; Region: Sulfatase; pfam00884 565655007992 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 565655007993 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 565655007994 homodimer interface [polypeptide binding]; other site 565655007995 NAD binding pocket [chemical binding]; other site 565655007996 ATP binding pocket [chemical binding]; other site 565655007997 Mg binding site [ion binding]; other site 565655007998 active-site loop [active] 565655007999 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 565655008000 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 565655008001 active site 565655008002 Domain of unknown function (DUF1827); Region: DUF1827; pfam08860 565655008003 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 565655008004 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 565655008005 active site 565655008006 motif I; other site 565655008007 motif II; other site 565655008008 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 565655008009 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 565655008010 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 565655008011 DNA binding residues [nucleotide binding] 565655008012 dimer interface [polypeptide binding]; other site 565655008013 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 565655008014 Transcriptional regulators [Transcription]; Region: PurR; COG1609 565655008015 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 565655008016 DNA binding site [nucleotide binding] 565655008017 domain linker motif; other site 565655008018 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 565655008019 putative dimerization interface [polypeptide binding]; other site 565655008020 putative ligand binding site [chemical binding]; other site 565655008021 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 565655008022 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 565655008023 non-specific DNA binding site [nucleotide binding]; other site 565655008024 salt bridge; other site 565655008025 sequence-specific DNA binding site [nucleotide binding]; other site 565655008026 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 565655008027 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 565655008028 Walker A/P-loop; other site 565655008029 ATP binding site [chemical binding]; other site 565655008030 Q-loop/lid; other site 565655008031 ABC transporter signature motif; other site 565655008032 Walker B; other site 565655008033 D-loop; other site 565655008034 H-loop/switch region; other site 565655008035 inner membrane transport permease; Provisional; Region: PRK15066 565655008036 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 565655008037 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 565655008038 active site turn [active] 565655008039 phosphorylation site [posttranslational modification] 565655008040 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 565655008041 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 565655008042 HPr interaction site; other site 565655008043 glycerol kinase (GK) interaction site [polypeptide binding]; other site 565655008044 active site 565655008045 phosphorylation site [posttranslational modification] 565655008046 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 565655008047 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 565655008048 metal binding site [ion binding]; metal-binding site 565655008049 substrate binding pocket [chemical binding]; other site 565655008050 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 565655008051 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 565655008052 DNA-binding site [nucleotide binding]; DNA binding site 565655008053 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 565655008054 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 565655008055 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 565655008056 DNA binding site [nucleotide binding] 565655008057 active site 565655008058 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 565655008059 Glucuronate isomerase; Region: UxaC; pfam02614 565655008060 mannonate dehydratase; Provisional; Region: PRK03906 565655008061 mannonate dehydratase; Region: uxuA; TIGR00695 565655008062 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 565655008063 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 565655008064 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 565655008065 Transcriptional regulators [Transcription]; Region: GntR; COG1802 565655008066 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 565655008067 DNA-binding site [nucleotide binding]; DNA binding site 565655008068 FCD domain; Region: FCD; pfam07729 565655008069 Uncharacterized conserved protein [Function unknown]; Region: COG1284 565655008070 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 565655008071 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 565655008072 Cation efflux family; Region: Cation_efflux; cl00316 565655008073 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 565655008074 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 565655008075 dimer interface [polypeptide binding]; other site 565655008076 FMN binding site [chemical binding]; other site 565655008077 NADPH bind site [chemical binding]; other site 565655008078 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 565655008079 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 565655008080 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 565655008081 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 565655008082 RNHCP domain; Region: RNHCP; pfam12647 565655008083 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 565655008084 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 565655008085 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 565655008086 Walker A/P-loop; other site 565655008087 ATP binding site [chemical binding]; other site 565655008088 Q-loop/lid; other site 565655008089 ABC transporter signature motif; other site 565655008090 Walker B; other site 565655008091 D-loop; other site 565655008092 H-loop/switch region; other site 565655008093 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 565655008094 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 565655008095 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 565655008096 Walker A/P-loop; other site 565655008097 ATP binding site [chemical binding]; other site 565655008098 Q-loop/lid; other site 565655008099 ABC transporter signature motif; other site 565655008100 Walker B; other site 565655008101 D-loop; other site 565655008102 H-loop/switch region; other site 565655008103 Protein of unknown function (DUF419); Region: DUF419; cl15265 565655008104 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 565655008105 xanthine permease; Region: pbuX; TIGR03173 565655008106 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 565655008107 guanine deaminase; Region: guan_deamin; TIGR02967 565655008108 active site 565655008109 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 565655008110 active site 565655008111 methionine cluster; other site 565655008112 phosphorylation site [posttranslational modification] 565655008113 metal binding site [ion binding]; metal-binding site 565655008114 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 565655008115 active site 565655008116 P-loop; other site 565655008117 phosphorylation site [posttranslational modification] 565655008118 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 565655008119 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 565655008120 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 565655008121 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 565655008122 HTH domain; Region: HTH_11; cl17392 565655008123 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 565655008124 Mga helix-turn-helix domain; Region: Mga; pfam05043 565655008125 PRD domain; Region: PRD; pfam00874 565655008126 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 565655008127 active site 565655008128 P-loop; other site 565655008129 phosphorylation site [posttranslational modification] 565655008130 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 565655008131 active site 565655008132 phosphorylation site [posttranslational modification] 565655008133 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 565655008134 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 565655008135 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 565655008136 putative deaminase; Validated; Region: PRK06846 565655008137 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 565655008138 active site 565655008139 Uncharacterized conserved protein [Function unknown]; Region: COG3538 565655008140 Protein of unknown function (DUF1237); Region: DUF1237; pfam06824 565655008141 Glycosyl hydrolase family 76; Region: Glyco_hydro_76; cl01996 565655008142 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 565655008143 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 565655008144 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 565655008145 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 565655008146 dimer interface [polypeptide binding]; other site 565655008147 conserved gate region; other site 565655008148 putative PBP binding loops; other site 565655008149 ABC-ATPase subunit interface; other site 565655008150 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 565655008151 dimer interface [polypeptide binding]; other site 565655008152 conserved gate region; other site 565655008153 putative PBP binding loops; other site 565655008154 ABC-ATPase subunit interface; other site 565655008155 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 565655008156 DNA-binding site [nucleotide binding]; DNA binding site 565655008157 Transcriptional regulators [Transcription]; Region: PurR; COG1609 565655008158 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 565655008159 dimerization interface [polypeptide binding]; other site 565655008160 ligand binding site [chemical binding]; other site 565655008161 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 565655008162 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 565655008163 substrate binding site [chemical binding]; other site 565655008164 dimer interface [polypeptide binding]; other site 565655008165 ATP binding site [chemical binding]; other site 565655008166 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 565655008167 C4-dicarboxylate transporter [Energy production and conversion]; Region: DcuC; cl17322 565655008168 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 565655008169 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 565655008170 active site 565655008171 tetramer interface [polypeptide binding]; other site 565655008172 Transcriptional regulators [Transcription]; Region: PurR; COG1609 565655008173 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 565655008174 DNA binding site [nucleotide binding] 565655008175 domain linker motif; other site 565655008176 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 565655008177 dimerization interface [polypeptide binding]; other site 565655008178 ligand binding site [chemical binding]; other site 565655008179 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 565655008180 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 565655008181 Alpha-L-fucosidase; Region: Alpha_L_fucos; smart00812 565655008182 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 565655008183 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 565655008184 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 565655008185 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 565655008186 dimer interface [polypeptide binding]; other site 565655008187 conserved gate region; other site 565655008188 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 565655008189 ABC-ATPase subunit interface; other site 565655008190 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 565655008191 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 565655008192 dimer interface [polypeptide binding]; other site 565655008193 conserved gate region; other site 565655008194 putative PBP binding loops; other site 565655008195 ABC-ATPase subunit interface; other site 565655008196 Protein of unknown function, DUF624; Region: DUF624; pfam04854 565655008197 Histidine kinase; Region: His_kinase; pfam06580 565655008198 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 565655008199 ATP binding site [chemical binding]; other site 565655008200 Mg2+ binding site [ion binding]; other site 565655008201 G-X-G motif; other site 565655008202 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 565655008203 Transposase; Region: DDE_Tnp_ISL3; pfam01610 565655008204 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 565655008205 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 565655008206 inhibitor binding site; inhibition site 565655008207 active site 565655008208 putative alpha-glucosidase; Provisional; Region: PRK10658 565655008209 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 565655008210 YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593 565655008211 active site 565655008212 homotrimer interface [polypeptide binding]; other site 565655008213 catalytic site [active] 565655008214 homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site 565655008215 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 565655008216 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 565655008217 nucleotide binding site [chemical binding]; other site 565655008218 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 565655008219 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 565655008220 active site 565655008221 phosphorylation site [posttranslational modification] 565655008222 intermolecular recognition site; other site 565655008223 dimerization interface [polypeptide binding]; other site 565655008224 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 565655008225 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 565655008226 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 565655008227 beta-galactosidase; Region: BGL; TIGR03356 565655008228 xylose isomerase; Provisional; Region: PRK05474 565655008229 xylose isomerase; Region: xylose_isom_A; TIGR02630 565655008230 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 565655008231 N- and C-terminal domain interface [polypeptide binding]; other site 565655008232 D-xylulose kinase; Region: XylB; TIGR01312 565655008233 active site 565655008234 MgATP binding site [chemical binding]; other site 565655008235 catalytic site [active] 565655008236 metal binding site [ion binding]; metal-binding site 565655008237 xylulose binding site [chemical binding]; other site 565655008238 homodimer interface [polypeptide binding]; other site 565655008239 MarR family; Region: MarR_2; pfam12802 565655008240 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 565655008241 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 565655008242 nucleotide binding site [chemical binding]; other site 565655008243 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 565655008244 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 565655008245 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 565655008246 dimer interface [polypeptide binding]; other site 565655008247 conserved gate region; other site 565655008248 putative PBP binding loops; other site 565655008249 ABC-ATPase subunit interface; other site 565655008250 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 565655008251 dimer interface [polypeptide binding]; other site 565655008252 conserved gate region; other site 565655008253 putative PBP binding loops; other site 565655008254 ABC-ATPase subunit interface; other site 565655008255 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 565655008256 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 565655008257 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 565655008258 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 565655008259 inhibitor binding site; inhibition site 565655008260 active site 565655008261 Cupin domain; Region: Cupin_2; pfam07883 565655008262 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 565655008263 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 565655008264 hypothetical protein; Provisional; Region: PRK11770 565655008265 Domain of unknown function (DUF307); Region: DUF307; pfam03733 565655008266 Domain of unknown function (DUF307); Region: DUF307; pfam03733 565655008267 Predicted secreted protein [Function unknown]; Region: COG4086 565655008268 Protein of unknown function (DUF1002); Region: DUF1002; pfam06207 565655008269 Acyltransferase family; Region: Acyl_transf_3; pfam01757 565655008270 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 565655008271 non-specific DNA binding site [nucleotide binding]; other site 565655008272 salt bridge; other site 565655008273 sequence-specific DNA binding site [nucleotide binding]; other site 565655008274 CAAX protease self-immunity; Region: Abi; pfam02517 565655008275 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 565655008276 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 565655008277 Walker A/P-loop; other site 565655008278 ATP binding site [chemical binding]; other site 565655008279 Q-loop/lid; other site 565655008280 ABC transporter signature motif; other site 565655008281 Walker B; other site 565655008282 D-loop; other site 565655008283 H-loop/switch region; other site 565655008284 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 565655008285 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 565655008286 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 565655008287 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 565655008288 putative active site [active] 565655008289 putative FMN binding site [chemical binding]; other site 565655008290 putative substrate binding site [chemical binding]; other site 565655008291 putative catalytic residue [active] 565655008292 FMN-binding domain; Region: FMN_bind; pfam04205 565655008293 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 565655008294 L-aspartate oxidase; Provisional; Region: PRK06175 565655008295 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 565655008296 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 565655008297 classical (c) SDRs; Region: SDR_c; cd05233 565655008298 NAD(P) binding site [chemical binding]; other site 565655008299 active site 565655008300 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 565655008301 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 565655008302 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 565655008303 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 565655008304 Major Facilitator Superfamily; Region: MFS_1; pfam07690 565655008305 putative substrate translocation pore; other site 565655008306 shikimate 5-dehydrogenase; Provisional; Region: PRK12548 565655008307 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 565655008308 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 565655008309 shikimate binding site; other site 565655008310 NAD(P) binding site [chemical binding]; other site 565655008311 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 565655008312 Transcriptional regulator [Transcription]; Region: LysR; COG0583 565655008313 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 565655008314 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 565655008315 putative dimerization interface [polypeptide binding]; other site 565655008316 Restriction endonuclease; Region: Mrr_cat; pfam04471 565655008317 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 565655008318 transcription termination factor Rho; Provisional; Region: rho; PRK09376 565655008319 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 565655008320 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 565655008321 RNA binding site [nucleotide binding]; other site 565655008322 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 565655008323 Walker A motif; other site 565655008324 ATP binding site [chemical binding]; other site 565655008325 Walker B motif; other site 565655008326 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 565655008327 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 565655008328 hinge; other site 565655008329 active site 565655008330 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 565655008331 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 565655008332 intersubunit interface [polypeptide binding]; other site 565655008333 active site 565655008334 zinc binding site [ion binding]; other site 565655008335 Na+ binding site [ion binding]; other site 565655008336 Protein of unknown function (DUF1307); Region: DUF1307; pfam06998 565655008337 CTP synthetase; Validated; Region: pyrG; PRK05380 565655008338 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 565655008339 Catalytic site [active] 565655008340 active site 565655008341 UTP binding site [chemical binding]; other site 565655008342 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 565655008343 active site 565655008344 putative oxyanion hole; other site 565655008345 catalytic triad [active] 565655008346 Glycosyl hydrolase family 53; Region: Glyco_hydro_53; cl06672 565655008347 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; cl17295 565655008348 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 565655008349 PTS_IIB_lactose: subunit IIB of enzyme II (EII) of the lactose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS) found in Firmicutes as well as Actinobacteria. In this system, EII is a lactose-specific permease with two...; Region: PTS_IIB_lactose; cd05565 565655008350 active site 565655008351 P-loop; other site 565655008352 phosphorylation site [posttranslational modification] 565655008353 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 565655008354 methionine cluster; other site 565655008355 active site 565655008356 phosphorylation site [posttranslational modification] 565655008357 metal binding site [ion binding]; metal-binding site 565655008358 6-phospho-beta-galactosidase; Provisional; Region: PRK13511 565655008359 beta-galactosidase; Region: BGL; TIGR03356 565655008360 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 565655008361 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 565655008362 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 565655008363 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 565655008364 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 565655008365 motif II; other site 565655008366 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298 565655008367 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 565655008368 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 565655008369 PhnA protein; Region: PhnA; pfam03831 565655008370 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 565655008371 ABC-ATPase subunit interface; other site 565655008372 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 565655008373 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 565655008374 Walker A/P-loop; other site 565655008375 ATP binding site [chemical binding]; other site 565655008376 Q-loop/lid; other site 565655008377 ABC transporter signature motif; other site 565655008378 Walker B; other site 565655008379 D-loop; other site 565655008380 H-loop/switch region; other site 565655008381 NIL domain; Region: NIL; pfam09383 565655008382 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 565655008383 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 565655008384 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 565655008385 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 565655008386 diaminopimelate decarboxylase; Region: lysA; TIGR01048 565655008387 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 565655008388 active site 565655008389 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 565655008390 substrate binding site [chemical binding]; other site 565655008391 catalytic residues [active] 565655008392 dimer interface [polypeptide binding]; other site 565655008393 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 565655008394 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 565655008395 metal binding site [ion binding]; metal-binding site 565655008396 dimer interface [polypeptide binding]; other site 565655008397 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 565655008398 dihydrodipicolinate synthase; Region: dapA; TIGR00674 565655008399 dimer interface [polypeptide binding]; other site 565655008400 active site 565655008401 catalytic residue [active] 565655008402 dihydrodipicolinate reductase; Provisional; Region: PRK00048 565655008403 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 565655008404 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 565655008405 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 565655008406 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 565655008407 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 565655008408 active site 565655008409 trimer interface [polypeptide binding]; other site 565655008410 substrate binding site [chemical binding]; other site 565655008411 CoA binding site [chemical binding]; other site 565655008412 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 565655008413 DHH family; Region: DHH; pfam01368 565655008414 DHHA1 domain; Region: DHHA1; pfam02272 565655008415 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 565655008416 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 565655008417 DNA-binding site [nucleotide binding]; DNA binding site 565655008418 DRTGG domain; Region: DRTGG; pfam07085 565655008419 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 565655008420 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 565655008421 metal-dependent hydrolase; Provisional; Region: PRK00685 565655008422 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 565655008423 Major Facilitator Superfamily; Region: MFS_1; pfam07690 565655008424 putative substrate translocation pore; other site 565655008425 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 565655008426 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 565655008427 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 565655008428 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 565655008429 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 565655008430 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 565655008431 maltodextrin glucosidase; Provisional; Region: PRK10785 565655008432 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 565655008433 homodimer interface [polypeptide binding]; other site 565655008434 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 565655008435 active site 565655008436 homodimer interface [polypeptide binding]; other site 565655008437 catalytic site [active] 565655008438 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 565655008439 MarR family; Region: MarR_2; pfam12802 565655008440 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 565655008441 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 565655008442 Walker A/P-loop; other site 565655008443 ATP binding site [chemical binding]; other site 565655008444 Q-loop/lid; other site 565655008445 ABC transporter signature motif; other site 565655008446 Walker B; other site 565655008447 D-loop; other site 565655008448 H-loop/switch region; other site 565655008449 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 565655008450 FtsX-like permease family; Region: FtsX; pfam02687 565655008451 manganese transport protein MntH; Reviewed; Region: PRK00701 565655008452 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 565655008453 Uncharacterized conserved protein [Function unknown]; Region: COG4198 565655008454 Protein of unknown function (DUF1015); Region: DUF1015; pfam06245 565655008455 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 565655008456 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_3; cd12174 565655008457 putative ligand binding site [chemical binding]; other site 565655008458 putative NAD binding site [chemical binding]; other site 565655008459 putative catalytic site [active] 565655008460 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 565655008461 L-serine binding site [chemical binding]; other site 565655008462 ACT domain interface; other site 565655008463 3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355 565655008464 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 565655008465 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 565655008466 catalytic residue [active] 565655008467 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 565655008468 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 565655008469 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 565655008470 beta-D-glucuronidase; Provisional; Region: PRK10150 565655008471 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 565655008472 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 565655008473 Predicted transcriptional regulator [Transcription]; Region: COG4189 565655008474 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 565655008475 putative DNA binding site [nucleotide binding]; other site 565655008476 dimerization interface [polypeptide binding]; other site 565655008477 putative Zn2+ binding site [ion binding]; other site 565655008478 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 565655008479 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 565655008480 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 565655008481 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 565655008482 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 565655008483 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 565655008484 conserved cys residue [active] 565655008485 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 565655008486 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 565655008487 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 565655008488 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 565655008489 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 565655008490 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 565655008491 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 565655008492 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 565655008493 hypothetical protein; Provisional; Region: PRK07329 565655008494 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 565655008495 active site 565655008496 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 565655008497 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 565655008498 motif II; other site 565655008499 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 565655008500 active site 565655008501 intersubunit interactions; other site 565655008502 catalytic residue [active] 565655008503 PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; pfam03829 565655008504 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 565655008505 PTS system, glucitol/sorbitol-specific, IIBC component; Region: EIIBC-GUT; TIGR00825 565655008506 Nucleoside recognition; Region: Gate; pfam07670 565655008507 Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663 565655008508 PTS system enzyme II sorbitol-specific factor; Region: EII-GUT; pfam03608 565655008509 Glucitol operon activator protein (GutM); Region: GutM; pfam06923 565655008510 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 565655008511 HTH domain; Region: HTH_11; pfam08279 565655008512 PRD domain; Region: PRD; pfam00874 565655008513 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 565655008514 active site 565655008515 P-loop; other site 565655008516 phosphorylation site [posttranslational modification] 565655008517 Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2; Region: PTS_EIIA_2; pfam00359 565655008518 active site 565655008519 phosphorylation site [posttranslational modification] 565655008520 sorbitol-6-phosphate 2-dehydrogenase; Provisional; Region: PRK06171 565655008521 classical (c) SDRs; Region: SDR_c; cd05233 565655008522 NAD(P) binding site [chemical binding]; other site 565655008523 active site 565655008524 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 565655008525 active site 565655008526 catalytic residues [active] 565655008527 Protein of unknown function (DUF1498); Region: DUF1498; cl17840 565655008528 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 565655008529 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 565655008530 active site 565655008531 P-loop; other site 565655008532 phosphorylation site [posttranslational modification] 565655008533 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 565655008534 intersubunit interface [polypeptide binding]; other site 565655008535 active site 565655008536 zinc binding site [ion binding]; other site 565655008537 Na+ binding site [ion binding]; other site 565655008538 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 565655008539 active site 565655008540 phosphorylation site [posttranslational modification] 565655008541 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 565655008542 HTH domain; Region: HTH_11; pfam08279 565655008543 PRD domain; Region: PRD; pfam00874 565655008544 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 565655008545 active site 565655008546 P-loop; other site 565655008547 phosphorylation site [posttranslational modification] 565655008548 tagatose 1,6-diphosphate aldolase; Reviewed; Region: PRK12399 565655008549 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 565655008550 active site 565655008551 phosphorylation site [posttranslational modification] 565655008552 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 565655008553 active site 565655008554 P-loop; other site 565655008555 phosphorylation site [posttranslational modification] 565655008556 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 565655008557 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 565655008558 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 565655008559 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 565655008560 putative substrate binding site [chemical binding]; other site 565655008561 putative ATP binding site [chemical binding]; other site 565655008562 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 565655008563 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 565655008564 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 565655008565 putative active site [active] 565655008566 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 565655008567 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 565655008568 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 565655008569 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 565655008570 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 565655008571 active site residue [active] 565655008572 Protein of unknown function (DUF3650); Region: DUF3650; pfam12368 565655008573 esterase; Provisional; Region: PRK10566 565655008574 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 565655008575 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 565655008576 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 565655008577 nucleotide binding site [chemical binding]; other site 565655008578 Tubby C 2; Region: Tub_2; cl02043 565655008579 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 565655008580 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_2; cd03402 565655008581 epoxyqueuosine reductase; Region: TIGR00276 565655008582 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 565655008583 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 565655008584 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 565655008585 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 565655008586 motif II; other site 565655008587 dihydroxyacetone kinase, phosphotransfer subunit; Region: dha_pts; TIGR02364 565655008588 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 565655008589 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 565655008590 dihydroxyacetone kinase, phosphoprotein-dependent, L subunit; Region: dha_L_ycgS; TIGR02365 565655008591 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 565655008592 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 565655008593 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 565655008594 catalytic triad [active] 565655008595 catalytic triad [active] 565655008596 oxyanion hole [active] 565655008597 Uncharacterized conserved protein [Function unknown]; Region: COG1284 565655008598 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 565655008599 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 565655008600 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 565655008601 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 565655008602 dimer interface [polypeptide binding]; other site 565655008603 anticodon binding site; other site 565655008604 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 565655008605 homodimer interface [polypeptide binding]; other site 565655008606 motif 1; other site 565655008607 active site 565655008608 motif 2; other site 565655008609 GAD domain; Region: GAD; pfam02938 565655008610 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 565655008611 motif 3; other site 565655008612 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 565655008613 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 565655008614 dimer interface [polypeptide binding]; other site 565655008615 motif 1; other site 565655008616 active site 565655008617 motif 2; other site 565655008618 motif 3; other site 565655008619 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 565655008620 anticodon binding site; other site 565655008621 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 565655008622 active site 565655008623 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 565655008624 Predicted membrane protein [Function unknown]; Region: COG3212 565655008625 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 565655008626 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 565655008627 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 565655008628 dimer interface [polypeptide binding]; other site 565655008629 phosphorylation site [posttranslational modification] 565655008630 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 565655008631 ATP binding site [chemical binding]; other site 565655008632 Mg2+ binding site [ion binding]; other site 565655008633 G-X-G motif; other site 565655008634 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 565655008635 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 565655008636 active site 565655008637 phosphorylation site [posttranslational modification] 565655008638 intermolecular recognition site; other site 565655008639 dimerization interface [polypeptide binding]; other site 565655008640 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 565655008641 DNA binding site [nucleotide binding] 565655008642 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 565655008643 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 565655008644 Walker A/P-loop; other site 565655008645 ATP binding site [chemical binding]; other site 565655008646 Q-loop/lid; other site 565655008647 ABC transporter signature motif; other site 565655008648 Walker B; other site 565655008649 D-loop; other site 565655008650 H-loop/switch region; other site 565655008651 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 565655008652 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 565655008653 Walker A/P-loop; other site 565655008654 ATP binding site [chemical binding]; other site 565655008655 Q-loop/lid; other site 565655008656 ABC transporter signature motif; other site 565655008657 Walker B; other site 565655008658 D-loop; other site 565655008659 H-loop/switch region; other site 565655008660 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 565655008661 Hypothetical bacterial integral membrane protein (Trep_Strep); Region: Trep_Strep; pfam09605 565655008662 PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; pfam03829 565655008663 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 565655008664 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 565655008665 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 565655008666 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 565655008667 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 565655008668 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 565655008669 E3 interaction surface; other site 565655008670 lipoyl attachment site [posttranslational modification]; other site 565655008671 e3 binding domain; Region: E3_binding; pfam02817 565655008672 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 565655008673 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 565655008674 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 565655008675 alpha subunit interface [polypeptide binding]; other site 565655008676 TPP binding site [chemical binding]; other site 565655008677 heterodimer interface [polypeptide binding]; other site 565655008678 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 565655008679 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 565655008680 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 565655008681 tetramer interface [polypeptide binding]; other site 565655008682 TPP-binding site [chemical binding]; other site 565655008683 heterodimer interface [polypeptide binding]; other site 565655008684 phosphorylation loop region [posttranslational modification] 565655008685 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 565655008686 Helix-turn-helix domain; Region: HTH_36; pfam13730 565655008687 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 565655008688 Predicted homoserine dehydrogenase [Amino acid transport and metabolism]; Region: COG4091 565655008689 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 565655008690 SAF domain of putative dehydrogenases or oxidoreductases; Region: SAF_DH_OX_like; cd11616 565655008691 Glucitol operon activator protein (GutM); Region: GutM; cl01890 565655008692 PTS system enzyme II sorbitol-specific factor; Region: EII-GUT; pfam03608 565655008693 Phosphotransferase system sorbitol-specific component IIBC [Carbohydrate transport and metabolism]; Region: SrlE; COG3732 565655008694 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 565655008695 Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663 565655008696 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 565655008697 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 565655008698 non-specific DNA binding site [nucleotide binding]; other site 565655008699 salt bridge; other site 565655008700 sequence-specific DNA binding site [nucleotide binding]; other site 565655008701 Mga helix-turn-helix domain; Region: Mga; pfam05043 565655008702 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 565655008703 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 565655008704 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 565655008705 Catalytic site [active] 565655008706 N-acetylmuramoyl-L-alanine amidase; Validated; Region: PRK08581 565655008707 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 565655008708 CHAP domain; Region: CHAP; pfam05257 565655008709 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 565655008710 active site 565655008711 catalytic site [active] 565655008712 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098 565655008713 active site 565655008714 catalytic site [active] 565655008715 Cna protein B-type domain; Region: Cna_B; pfam05738 565655008716 Cna protein B-type domain; Region: Cna_B; pfam05738 565655008717 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 565655008718 23S rRNA binding site [nucleotide binding]; other site 565655008719 L21 binding site [polypeptide binding]; other site 565655008720 L13 binding site [polypeptide binding]; other site 565655008721 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 565655008722 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 565655008723 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 565655008724 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 565655008725 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 565655008726 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 565655008727 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 565655008728 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 565655008729 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 565655008730 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 565655008731 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 565655008732 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 565655008733 Cl binding site [ion binding]; other site 565655008734 oligomer interface [polypeptide binding]; other site 565655008735 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 565655008736 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 565655008737 Substrate-binding site [chemical binding]; other site 565655008738 Substrate specificity [chemical binding]; other site 565655008739 mevalonate kinase; Region: mevalon_kin; TIGR00549 565655008740 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 565655008741 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 565655008742 diphosphomevalonate decarboxylase; Region: mevDPdecarb; TIGR01240 565655008743 diphosphomevalonate decarboxylase; Region: PLN02407 565655008744 phosphomevalonate kinase, ERG8-type, Gram-positive branch; Region: Pmev_kin_Gr_pos; TIGR01220 565655008745 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 565655008746 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 565655008747 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 565655008748 homotetramer interface [polypeptide binding]; other site 565655008749 FMN binding site [chemical binding]; other site 565655008750 homodimer contacts [polypeptide binding]; other site 565655008751 putative active site [active] 565655008752 putative substrate binding site [chemical binding]; other site 565655008753 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 565655008754 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 565655008755 Soluble P-type ATPase [General function prediction only]; Region: COG4087 565655008756 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 565655008757 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 565655008758 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 565655008759 beta-galactosidase; Region: BGL; TIGR03356 565655008760 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 565655008761 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 565655008762 RNase E interface [polypeptide binding]; other site 565655008763 trimer interface [polypeptide binding]; other site 565655008764 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 565655008765 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 565655008766 RNase E interface [polypeptide binding]; other site 565655008767 trimer interface [polypeptide binding]; other site 565655008768 active site 565655008769 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 565655008770 putative nucleic acid binding region [nucleotide binding]; other site 565655008771 G-X-X-G motif; other site 565655008772 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 565655008773 RNA binding site [nucleotide binding]; other site 565655008774 domain interface; other site 565655008775 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 565655008776 16S/18S rRNA binding site [nucleotide binding]; other site 565655008777 S13e-L30e interaction site [polypeptide binding]; other site 565655008778 25S rRNA binding site [nucleotide binding]; other site 565655008779 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 565655008780 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 565655008781 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 565655008782 putative active site [active] 565655008783 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 565655008784 beta-galactosidase; Region: BGL; TIGR03356 565655008785 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 565655008786 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 565655008787 N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789 565655008788 active site 565655008789 catalytic site [active] 565655008790 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; pfam09261 565655008791 Glycosyl hydrolases family 38 C-terminal domain; Region: Glyco_hydro_38C; pfam07748 565655008792 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 565655008793 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 565655008794 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 565655008795 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 565655008796 dimer interface [polypeptide binding]; other site 565655008797 conserved gate region; other site 565655008798 putative PBP binding loops; other site 565655008799 ABC-ATPase subunit interface; other site 565655008800 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 565655008801 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 565655008802 dimer interface [polypeptide binding]; other site 565655008803 conserved gate region; other site 565655008804 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 565655008805 ABC-ATPase subunit interface; other site 565655008806 Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119 565655008807 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 565655008808 Protein of unknown function, DUF624; Region: DUF624; cl02369 565655008809 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 565655008810 Glycosyl hydrolase family 20 (GH20) catalytic domain of N-acetyl-beta-D-glucosaminidase (GcnA, also known as BhsA) and related proteins. GcnA is an exoglucosidase which cleaves N-acetyl-beta-D-galactosamine (NAG) and N-acetyl-beta-D-galactosamine...; Region: GH20_GcnA-like; cd06565 565655008811 putative active site [active] 565655008812 Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119 565655008813 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 565655008814 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 565655008815 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 565655008816 Coenzyme A binding pocket [chemical binding]; other site 565655008817 Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides; Region: GH20_hexosaminidase; cl02948 565655008818 active site 565655008819 Helix-turn-helix domain; Region: HTH_18; pfam12833 565655008820 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 565655008821 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 565655008822 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 565655008823 nucleotide binding site [chemical binding]; other site 565655008824 Flavodoxin domain; Region: Flavodoxin_5; pfam12724 565655008825 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 565655008826 WHG domain; Region: WHG; pfam13305 565655008827 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 565655008828 Domain of unknown function DUF20; Region: UPF0118; pfam01594 565655008829 PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; cl01516 565655008830 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 565655008831 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 565655008832 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 565655008833 active site 565655008834 metal binding site [ion binding]; metal-binding site 565655008835 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 565655008836 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 565655008837 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 565655008838 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 565655008839 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 565655008840 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 565655008841 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 565655008842 dimer interface [polypeptide binding]; other site 565655008843 conserved gate region; other site 565655008844 putative PBP binding loops; other site 565655008845 ABC-ATPase subunit interface; other site 565655008846 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 565655008847 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 565655008848 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 565655008849 putative PBP binding loops; other site 565655008850 ABC-ATPase subunit interface; other site 565655008851 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 565655008852 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 565655008853 Walker A/P-loop; other site 565655008854 ATP binding site [chemical binding]; other site 565655008855 Q-loop/lid; other site 565655008856 ABC transporter signature motif; other site 565655008857 Walker B; other site 565655008858 D-loop; other site 565655008859 H-loop/switch region; other site 565655008860 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 565655008861 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 565655008862 ABC transporter; Region: ABC_tran_2; pfam12848 565655008863 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 565655008864 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: PhosphMutase; cl17294 565655008865 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 565655008866 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 565655008867 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 565655008868 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 565655008869 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 565655008870 motif II; other site 565655008871 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 565655008872 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 565655008873 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 565655008874 active site 565655008875 HIGH motif; other site 565655008876 KMSKS motif; other site 565655008877 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 565655008878 tRNA binding surface [nucleotide binding]; other site 565655008879 anticodon binding site; other site 565655008880 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 565655008881 dimer interface [polypeptide binding]; other site 565655008882 putative tRNA-binding site [nucleotide binding]; other site 565655008883 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 565655008884 nudix motif; other site 565655008885 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 565655008886 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 565655008887 Probable transposase; Region: OrfB_IS605; pfam01385 565655008888 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 565655008889 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 565655008890 Walker A/P-loop; other site 565655008891 ATP binding site [chemical binding]; other site 565655008892 Q-loop/lid; other site 565655008893 ABC transporter signature motif; other site 565655008894 Walker B; other site 565655008895 D-loop; other site 565655008896 H-loop/switch region; other site 565655008897 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 565655008898 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 565655008899 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 565655008900 Walker A/P-loop; other site 565655008901 ATP binding site [chemical binding]; other site 565655008902 Q-loop/lid; other site 565655008903 ABC transporter signature motif; other site 565655008904 Walker B; other site 565655008905 D-loop; other site 565655008906 H-loop/switch region; other site 565655008907 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 565655008908 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 565655008909 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 565655008910 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 565655008911 dimer interface [polypeptide binding]; other site 565655008912 conserved gate region; other site 565655008913 putative PBP binding loops; other site 565655008914 ABC-ATPase subunit interface; other site 565655008915 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 565655008916 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 565655008917 dimer interface [polypeptide binding]; other site 565655008918 conserved gate region; other site 565655008919 putative PBP binding loops; other site 565655008920 ABC-ATPase subunit interface; other site 565655008921 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 565655008922 peptide binding site [polypeptide binding]; other site 565655008923 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 565655008924 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 565655008925 putative substrate binding pocket [chemical binding]; other site 565655008926 AC domain interface; other site 565655008927 catalytic triad [active] 565655008928 AB domain interface; other site 565655008929 interchain disulfide; other site 565655008930 Predicted membrane protein [Function unknown]; Region: COG3817 565655008931 Protein of unknown function (DUF979); Region: DUF979; pfam06166 565655008932 Protein of unknown function (DUF969); Region: DUF969; pfam06149 565655008933 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 565655008934 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 565655008935 FeS/SAM binding site; other site 565655008936 PemK-like protein; Region: PemK; pfam02452 565655008937 alanine racemase; Reviewed; Region: alr; PRK00053 565655008938 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 565655008939 active site 565655008940 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 565655008941 dimer interface [polypeptide binding]; other site 565655008942 substrate binding site [chemical binding]; other site 565655008943 catalytic residues [active] 565655008944 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 565655008945 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 565655008946 DEAD-like helicases superfamily; Region: DEXDc; smart00487 565655008947 ATP binding site [chemical binding]; other site 565655008948 Mg++ binding site [ion binding]; other site 565655008949 motif III; other site 565655008950 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 565655008951 nucleotide binding region [chemical binding]; other site 565655008952 ATP-binding site [chemical binding]; other site 565655008953 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 565655008954 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 565655008955 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 565655008956 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 565655008957 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 565655008958 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 565655008959 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 565655008960 ABC1 family; Region: ABC1; cl17513 565655008961 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 565655008962 hypothetical protein; Validated; Region: PRK00124 565655008963 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 565655008964 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 565655008965 Walker A/P-loop; other site 565655008966 ATP binding site [chemical binding]; other site 565655008967 Q-loop/lid; other site 565655008968 ABC transporter signature motif; other site 565655008969 Walker B; other site 565655008970 D-loop; other site 565655008971 H-loop/switch region; other site 565655008972 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 565655008973 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 565655008974 FtsX-like permease family; Region: FtsX; pfam02687 565655008975 Domain of unknown function (DUF4353); Region: DUF4353; pfam14262 565655008976 Domain of unknown function (DUF4353); Region: DUF4353; pfam14262 565655008977 Polyphosphate(polyP) polymerase domain of yeast vacuolar transport chaperone (VTC) proteins VTC-2, -3 and- 4, and similar proteins; Region: PolyPPase_VTC_like; cd07750 565655008978 putative metal binding residues [ion binding]; other site 565655008979 signature motif; other site 565655008980 dimer interface [polypeptide binding]; other site 565655008981 active site 565655008982 polyP binding site; other site 565655008983 substrate binding site [chemical binding]; other site 565655008984 acceptor-phosphate pocket; other site 565655008985 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 565655008986 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 565655008987 active site 565655008988 phosphorylation site [posttranslational modification] 565655008989 intermolecular recognition site; other site 565655008990 dimerization interface [polypeptide binding]; other site 565655008991 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 565655008992 DNA binding site [nucleotide binding] 565655008993 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 565655008994 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 565655008995 dimer interface [polypeptide binding]; other site 565655008996 phosphorylation site [posttranslational modification] 565655008997 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 565655008998 ATP binding site [chemical binding]; other site 565655008999 Mg2+ binding site [ion binding]; other site 565655009000 G-X-G motif; other site 565655009001 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 565655009002 Coenzyme A binding pocket [chemical binding]; other site 565655009003 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 565655009004 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 565655009005 Sugar specificity; other site 565655009006 Pyrimidine base specificity; other site 565655009007 ATP-binding site [chemical binding]; other site 565655009008 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 565655009009 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 565655009010 motif II; other site 565655009011 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 565655009012 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 565655009013 RNA binding surface [nucleotide binding]; other site 565655009014 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 565655009015 active site 565655009016 uracil binding [chemical binding]; other site 565655009017 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 565655009018 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 565655009019 5S rRNA interface [nucleotide binding]; other site 565655009020 CTC domain interface [polypeptide binding]; other site 565655009021 L16 interface [polypeptide binding]; other site 565655009022 Staphylococcal protein of unknown function (DUF960); Region: DUF960; pfam06124 565655009023 Mga helix-turn-helix domain; Region: Mga; pfam05043 565655009024 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 565655009025 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 565655009026 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 565655009027 dimer interface [polypeptide binding]; other site 565655009028 conserved gate region; other site 565655009029 ABC-ATPase subunit interface; other site 565655009030 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 565655009031 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 565655009032 Walker A/P-loop; other site 565655009033 ATP binding site [chemical binding]; other site 565655009034 Q-loop/lid; other site 565655009035 ABC transporter signature motif; other site 565655009036 Walker B; other site 565655009037 D-loop; other site 565655009038 H-loop/switch region; other site 565655009039 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 565655009040 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 565655009041 lipoyl attachment site [posttranslational modification]; other site 565655009042 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 565655009043 ArsC family; Region: ArsC; pfam03960 565655009044 putative ArsC-like catalytic residues; other site 565655009045 putative TRX-like catalytic residues [active] 565655009046 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 565655009047 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 565655009048 PRD domain; Region: PRD; pfam00874 565655009049 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 565655009050 active site 565655009051 P-loop; other site 565655009052 phosphorylation site [posttranslational modification] 565655009053 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 565655009054 active site 565655009055 phosphorylation site [posttranslational modification] 565655009056 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 565655009057 active site 565655009058 phosphorylation site [posttranslational modification] 565655009059 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 565655009060 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 565655009061 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 565655009062 active site 565655009063 P-loop; other site 565655009064 phosphorylation site [posttranslational modification] 565655009065 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 565655009066 intersubunit interface [polypeptide binding]; other site 565655009067 active site 565655009068 zinc binding site [ion binding]; other site 565655009069 Na+ binding site [ion binding]; other site 565655009070 triosephosphate isomerase; Provisional; Region: PRK04302 565655009071 Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894 565655009072 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 565655009073 active site 565655009074 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 565655009075 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 565655009076 dimer interface [polypeptide binding]; other site 565655009077 active site 565655009078 glycine-pyridoxal phosphate binding site [chemical binding]; other site 565655009079 folate binding site [chemical binding]; other site 565655009080 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 565655009081 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 565655009082 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 565655009083 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 565655009084 S-adenosylmethionine binding site [chemical binding]; other site 565655009085 peptide chain release factor 1; Validated; Region: prfA; PRK00591 565655009086 This domain is found in peptide chain release factors; Region: PCRF; smart00937 565655009087 RF-1 domain; Region: RF-1; pfam00472 565655009088 thymidine kinase; Provisional; Region: PRK04296 565655009089 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 565655009090 Coenzyme A binding pocket [chemical binding]; other site 565655009091 methionine sulfoxide reductase A; Provisional; Region: PRK14054 565655009092 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 565655009093 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 565655009094 putative active site [active] 565655009095 metal binding site [ion binding]; metal-binding site 565655009096 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 565655009097 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 565655009098 active site 565655009099 motif I; other site 565655009100 motif II; other site 565655009101 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 565655009102 motif II; other site 565655009103 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 565655009104 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 565655009105 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 565655009106 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 565655009107 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 565655009108 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 565655009109 catalytic triad [active] 565655009110 PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005 565655009111 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 565655009112 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 565655009113 active site turn [active] 565655009114 phosphorylation site [posttranslational modification] 565655009115 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 565655009116 Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298 565655009117 NAD binding site [chemical binding]; other site 565655009118 sugar binding site [chemical binding]; other site 565655009119 divalent metal binding site [ion binding]; other site 565655009120 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 565655009121 dimer interface [polypeptide binding]; other site 565655009122 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 565655009123 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 565655009124 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 565655009125 putative active site [active] 565655009126 Streptococcus agalactiae RgfB, part of a putative two component signal transduction system, and related proteins; Region: RgfB-like; cd09079 565655009127 putative catalytic site [active] 565655009128 putative metal binding site [ion binding]; other site 565655009129 putative phosphate binding site [ion binding]; other site 565655009130 PTS system, IIBC component; Region: PTS-II-BC-unk1; TIGR02003 565655009131 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 565655009132 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 565655009133 active site turn [active] 565655009134 phosphorylation site [posttranslational modification] 565655009135 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 565655009136 HPr interaction site; other site 565655009137 glycerol kinase (GK) interaction site [polypeptide binding]; other site 565655009138 active site 565655009139 phosphorylation site [posttranslational modification] 565655009140 maltose phosphorylase; Provisional; Region: PRK13807 565655009141 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 565655009142 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 565655009143 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 565655009144 Transcriptional regulators [Transcription]; Region: PurR; COG1609 565655009145 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 565655009146 DNA binding site [nucleotide binding] 565655009147 domain linker motif; other site 565655009148 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 565655009149 putative dimerization interface [polypeptide binding]; other site 565655009150 putative ligand binding site [chemical binding]; other site 565655009151 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02458 565655009152 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 565655009153 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 565655009154 active site 565655009155 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 565655009156 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 565655009157 active site 565655009158 Zn binding site [ion binding]; other site 565655009159 Isochorismatase family; Region: Isochorismatase; pfam00857 565655009160 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 565655009161 catalytic triad [active] 565655009162 conserved cis-peptide bond; other site 565655009163 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 565655009164 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 565655009165 Methyltransferase domain; Region: Methyltransf_23; pfam13489 565655009166 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 565655009167 S-adenosylmethionine binding site [chemical binding]; other site 565655009168 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 565655009169 dimer interface [polypeptide binding]; other site 565655009170 ADP-ribose binding site [chemical binding]; other site 565655009171 active site 565655009172 nudix motif; other site 565655009173 metal binding site [ion binding]; metal-binding site 565655009174 5-bromo-4-chloroindolyl phosphate hydrolysis protein; Region: Halogen_Hydrol; pfam10112 565655009175 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 565655009176 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 565655009177 dimer interface [polypeptide binding]; other site 565655009178 phosphorylation site [posttranslational modification] 565655009179 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 565655009180 ATP binding site [chemical binding]; other site 565655009181 Mg2+ binding site [ion binding]; other site 565655009182 G-X-G motif; other site 565655009183 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 565655009184 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 565655009185 active site 565655009186 phosphorylation site [posttranslational modification] 565655009187 intermolecular recognition site; other site 565655009188 dimerization interface [polypeptide binding]; other site 565655009189 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 565655009190 DNA binding site [nucleotide binding] 565655009191 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768 565655009192 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 565655009193 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 565655009194 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 565655009195 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 565655009196 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 565655009197 Walker A/P-loop; other site 565655009198 ATP binding site [chemical binding]; other site 565655009199 Q-loop/lid; other site 565655009200 ABC transporter signature motif; other site 565655009201 Walker B; other site 565655009202 D-loop; other site 565655009203 H-loop/switch region; other site 565655009204 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 565655009205 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 565655009206 FtsX-like permease family; Region: FtsX; pfam02687 565655009207 amino acid transporter; Region: 2A0306; TIGR00909 565655009208 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 565655009209 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 565655009210 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 565655009211 His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388 565655009212 dimer interface [polypeptide binding]; other site 565655009213 phosphorylation site [posttranslational modification] 565655009214 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 565655009215 ATP binding site [chemical binding]; other site 565655009216 Mg2+ binding site [ion binding]; other site 565655009217 G-X-G motif; other site 565655009218 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 565655009219 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 565655009220 active site 565655009221 phosphorylation site [posttranslational modification] 565655009222 intermolecular recognition site; other site 565655009223 dimerization interface [polypeptide binding]; other site 565655009224 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 565655009225 DNA binding site [nucleotide binding] 565655009226 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 565655009227 active site 565655009228 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 565655009229 substrate binding site [chemical binding]; other site 565655009230 metal binding site [ion binding]; metal-binding site 565655009231 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 565655009232 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 565655009233 DNA binding site [nucleotide binding] 565655009234 active site 565655009235 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 565655009236 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 565655009237 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 565655009238 Walker A/P-loop; other site 565655009239 ATP binding site [chemical binding]; other site 565655009240 Q-loop/lid; other site 565655009241 ABC transporter signature motif; other site 565655009242 Walker B; other site 565655009243 D-loop; other site 565655009244 H-loop/switch region; other site 565655009245 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 565655009246 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 565655009247 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 565655009248 Walker A/P-loop; other site 565655009249 ATP binding site [chemical binding]; other site 565655009250 Q-loop/lid; other site 565655009251 ABC transporter signature motif; other site 565655009252 Walker B; other site 565655009253 D-loop; other site 565655009254 H-loop/switch region; other site 565655009255 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 565655009256 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 565655009257 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 565655009258 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 565655009259 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 565655009260 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 565655009261 Walker A/P-loop; other site 565655009262 ATP binding site [chemical binding]; other site 565655009263 Q-loop/lid; other site 565655009264 ABC transporter signature motif; other site 565655009265 Walker B; other site 565655009266 D-loop; other site 565655009267 H-loop/switch region; other site 565655009268 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 565655009269 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 565655009270 putative active site [active] 565655009271 dimerization interface [polypeptide binding]; other site 565655009272 putative tRNAtyr binding site [nucleotide binding]; other site 565655009273 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 565655009274 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 565655009275 Zn2+ binding site [ion binding]; other site 565655009276 Mg2+ binding site [ion binding]; other site 565655009277 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 565655009278 synthetase active site [active] 565655009279 NTP binding site [chemical binding]; other site 565655009280 metal binding site [ion binding]; metal-binding site 565655009281 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 565655009282 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 565655009283 Class I aldolases; Region: Aldolase_Class_I; cl17187 565655009284 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 565655009285 RNA methyltransferase, RsmE family; Region: TIGR00046 565655009286 Ribosomal protein L11 methylase [Translation, ribosomal structure and biogenesis]; Region: PrmA; COG2264 565655009287 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 565655009288 S-adenosylmethionine binding site [chemical binding]; other site 565655009289 Protein of unknown function (DUF3013); Region: DUF3013; pfam11217 565655009290 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 565655009291 active site 565655009292 DNA binding site [nucleotide binding] 565655009293 recombination factor protein RarA; Reviewed; Region: PRK13342 565655009294 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 565655009295 Walker A motif; other site 565655009296 ATP binding site [chemical binding]; other site 565655009297 Walker B motif; other site 565655009298 arginine finger; other site 565655009299 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 565655009300 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 565655009301 Ligand Binding Site [chemical binding]; other site 565655009302 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 565655009303 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 565655009304 Walker A/P-loop; other site 565655009305 ATP binding site [chemical binding]; other site 565655009306 Q-loop/lid; other site 565655009307 ABC transporter signature motif; other site 565655009308 Walker B; other site 565655009309 D-loop; other site 565655009310 H-loop/switch region; other site 565655009311 K+ potassium transporter; Region: K_trans; cl15781 565655009312 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 565655009313 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 565655009314 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 565655009315 ABC transporter; Region: ABC_tran_2; pfam12848 565655009316 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 565655009317 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 565655009318 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 565655009319 putative substrate translocation pore; other site 565655009320 POT family; Region: PTR2; cl17359 565655009321 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 565655009322 propionate/acetate kinase; Provisional; Region: PRK12379 565655009323 nucleotide binding site [chemical binding]; other site 565655009324 butyrate kinase; Provisional; Region: PRK03011 565655009325 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 565655009326 Methyltransferase domain; Region: Methyltransf_26; pfam13659 565655009327 Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940 565655009328 type IV pilus modification protein PilV; Region: type_IV_pilV; TIGR02523 565655009329 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 565655009330 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 565655009331 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 565655009332 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 565655009333 Walker A motif; other site 565655009334 ATP binding site [chemical binding]; other site 565655009335 Walker B motif; other site 565655009336 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 565655009337 Phosphotransferase enzyme family; Region: APH; pfam01636 565655009338 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 565655009339 active site 565655009340 substrate binding site [chemical binding]; other site 565655009341 ATP binding site [chemical binding]; other site 565655009342 Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975 565655009343 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 565655009344 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 565655009345 Walker A/P-loop; other site 565655009346 ATP binding site [chemical binding]; other site 565655009347 Q-loop/lid; other site 565655009348 ABC transporter signature motif; other site 565655009349 Walker B; other site 565655009350 D-loop; other site 565655009351 H-loop/switch region; other site 565655009352 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 565655009353 HIT family signature motif; other site 565655009354 catalytic residue [active] 565655009355 YtxH-like protein; Region: YtxH; pfam12732 565655009356 foldase protein PrsA; Reviewed; Region: prsA; PRK01326 565655009357 SurA N-terminal domain; Region: SurA_N_3; cl07813 565655009358 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 565655009359 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 565655009360 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 565655009361 generic binding surface II; other site 565655009362 generic binding surface I; other site 565655009363 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 565655009364 Zn2+ binding site [ion binding]; other site 565655009365 Mg2+ binding site [ion binding]; other site 565655009366 AAA domain; Region: AAA_23; pfam13476 565655009367 P-loop containing region of AAA domain; Region: AAA_29; cl17516 565655009368 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 565655009369 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 565655009370 active site 565655009371 metal binding site [ion binding]; metal-binding site 565655009372 DNA binding site [nucleotide binding] 565655009373 hypothetical protein; Provisional; Region: PRK13676 565655009374 Transglycosylase; Region: Transgly; pfam00912 565655009375 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 565655009376 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 565655009377 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 565655009378 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 565655009379 active site 565655009380 FlgN protein; Region: FlgN; pfam05130 565655009381 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 565655009382 Peptidase family M23; Region: Peptidase_M23; pfam01551 565655009383 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 565655009384 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 565655009385 RNA binding surface [nucleotide binding]; other site 565655009386 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 565655009387 active site 565655009388 uracil binding [chemical binding]; other site 565655009389 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 565655009390 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 565655009391 UDP-N-acetylmuramoylalanyl-D-glutamate--L-lysine ligase; Provisional; Region: PRK14022 565655009392 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 565655009393 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 565655009394 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 565655009395 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 565655009396 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 565655009397 HIGH motif; other site 565655009398 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 565655009399 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 565655009400 active site 565655009401 KMSKS motif; other site 565655009402 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 565655009403 tRNA binding surface [nucleotide binding]; other site 565655009404 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 565655009405 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 565655009406 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 565655009407 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 565655009408 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 565655009409 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 565655009410 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 565655009411 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 565655009412 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 565655009413 active site 565655009414 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 565655009415 Methyltransferase domain; Region: Methyltransf_31; pfam13847 565655009416 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 565655009417 S-adenosylmethionine binding site [chemical binding]; other site 565655009418 Putative esterase; Region: Esterase; pfam00756 565655009419 S-formylglutathione hydrolase; Region: PLN02442 565655009420 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 565655009421 Major Facilitator Superfamily; Region: MFS_1; pfam07690 565655009422 putative substrate translocation pore; other site 565655009423 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 565655009424 S-adenosylmethionine synthetase; Validated; Region: PRK05250 565655009425 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 565655009426 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 565655009427 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 565655009428 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 565655009429 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 565655009430 dimer interface [polypeptide binding]; other site 565655009431 putative anticodon binding site; other site 565655009432 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 565655009433 motif 1; other site 565655009434 active site 565655009435 motif 2; other site 565655009436 motif 3; other site 565655009437 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 565655009438 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 565655009439 FMN binding site [chemical binding]; other site 565655009440 active site 565655009441 catalytic residues [active] 565655009442 substrate binding site [chemical binding]; other site 565655009443 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 565655009444 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 565655009445 dimerization interface [polypeptide binding]; other site 565655009446 domain crossover interface; other site 565655009447 redox-dependent activation switch; other site 565655009448 FtsH Extracellular; Region: FtsH_ext; pfam06480 565655009449 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 565655009450 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 565655009451 Walker A motif; other site 565655009452 ATP binding site [chemical binding]; other site 565655009453 Walker B motif; other site 565655009454 arginine finger; other site 565655009455 Peptidase family M41; Region: Peptidase_M41; pfam01434 565655009456 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 565655009457 active site 565655009458 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 565655009459 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 565655009460 Ligand Binding Site [chemical binding]; other site 565655009461 TilS substrate C-terminal domain; Region: TilS_C; smart00977 565655009462 hypothetical protein; Provisional; Region: PRK08582 565655009463 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 565655009464 RNA binding site [nucleotide binding]; other site 565655009465 Septum formation initiator; Region: DivIC; pfam04977 565655009466 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 565655009467 RNA binding surface [nucleotide binding]; other site 565655009468 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 565655009469 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 565655009470 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 565655009471 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 565655009472 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 565655009473 ATP binding site [chemical binding]; other site 565655009474 putative Mg++ binding site [ion binding]; other site 565655009475 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 565655009476 nucleotide binding region [chemical binding]; other site 565655009477 ATP-binding site [chemical binding]; other site 565655009478 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 565655009479 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 565655009480 putative active site [active] 565655009481 catalytic residue [active] 565655009482 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 565655009483 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 565655009484 tetramer (dimer of dimers) interface [polypeptide binding]; other site 565655009485 NAD binding site [chemical binding]; other site 565655009486 dimer interface [polypeptide binding]; other site 565655009487 substrate binding site [chemical binding]; other site 565655009488 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 565655009489 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 565655009490 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 565655009491 Predicted transcriptional regulators [Transcription]; Region: COG1733 565655009492 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 565655009493 putative Zn2+ binding site [ion binding]; other site 565655009494 putative DNA binding site [nucleotide binding]; other site 565655009495 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 565655009496 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 565655009497 active site 565655009498 catalytic tetrad [active] 565655009499 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 565655009500 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 565655009501 active site 565655009502 metal binding site [ion binding]; metal-binding site 565655009503 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 565655009504 Predicted integral membrane protein [Function unknown]; Region: COG5652 565655009505 Arginine repressor [Transcription]; Region: ArgR; COG1438 565655009506 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 565655009507 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 565655009508 Predicted membrane protein [Function unknown]; Region: COG1288 565655009509 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 565655009510 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 565655009511 ligand binding site [chemical binding]; other site 565655009512 flexible hinge region; other site 565655009513 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 565655009514 putative switch regulator; other site 565655009515 non-specific DNA interactions [nucleotide binding]; other site 565655009516 DNA binding site [nucleotide binding] 565655009517 sequence specific DNA binding site [nucleotide binding]; other site 565655009518 putative cAMP binding site [chemical binding]; other site 565655009519 carbamate kinase; Reviewed; Region: PRK12686 565655009520 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 565655009521 putative substrate binding site [chemical binding]; other site 565655009522 nucleotide binding site [chemical binding]; other site 565655009523 nucleotide binding site [chemical binding]; other site 565655009524 homodimer interface [polypeptide binding]; other site 565655009525 ornithine carbamoyltransferase; Validated; Region: PRK02102 565655009526 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 565655009527 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 565655009528 arginine deiminase; Provisional; Region: PRK01388 565655009529 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 565655009530 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_2; cd09607 565655009531 active site 565655009532 Zn binding site [ion binding]; other site 565655009533 TspO/MBR family; Region: TspO_MBR; pfam03073 565655009534 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 565655009535 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 565655009536 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 565655009537 methionine cluster; other site 565655009538 active site 565655009539 phosphorylation site [posttranslational modification] 565655009540 metal binding site [ion binding]; metal-binding site 565655009541 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 565655009542 HTH domain; Region: HTH_11; pfam08279 565655009543 Mga helix-turn-helix domain; Region: Mga; pfam05043 565655009544 PRD domain; Region: PRD; pfam00874 565655009545 PRD domain; Region: PRD; pfam00874 565655009546 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 565655009547 active site 565655009548 P-loop; other site 565655009549 phosphorylation site [posttranslational modification] 565655009550 Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2; Region: PTS_EIIA_2; pfam00359 565655009551 active site 565655009552 phosphorylation site [posttranslational modification] 565655009553 cellobiose phosphotransferase system IIB component; Reviewed; Region: celB; PRK09590 565655009554 active site 565655009555 P-loop; other site 565655009556 phosphorylation site [posttranslational modification] 565655009557 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 565655009558 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 565655009559 Ligand binding site; other site 565655009560 metal-binding site 565655009561 Predicted flavoprotein [General function prediction only]; Region: COG0431 565655009562 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 565655009563 Predicted flavoprotein [General function prediction only]; Region: COG0431 565655009564 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 565655009565 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 565655009566 Transcriptional regulators [Transcription]; Region: MarR; COG1846 565655009567 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 565655009568 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 565655009569 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 565655009570 Walker A/P-loop; other site 565655009571 ATP binding site [chemical binding]; other site 565655009572 Q-loop/lid; other site 565655009573 ABC transporter signature motif; other site 565655009574 Walker B; other site 565655009575 D-loop; other site 565655009576 H-loop/switch region; other site 565655009577 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 565655009578 sequence-specific DNA binding site [nucleotide binding]; other site 565655009579 salt bridge; other site 565655009580 Domain of unknown function (DUF955); Region: DUF955; pfam06114 565655009581 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 565655009582 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 565655009583 active site 565655009584 metal binding site [ion binding]; metal-binding site 565655009585 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 565655009586 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 565655009587 dimer interface [polypeptide binding]; other site 565655009588 conserved gate region; other site 565655009589 putative PBP binding loops; other site 565655009590 ABC-ATPase subunit interface; other site 565655009591 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 565655009592 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 565655009593 dimer interface [polypeptide binding]; other site 565655009594 conserved gate region; other site 565655009595 putative PBP binding loops; other site 565655009596 ABC-ATPase subunit interface; other site 565655009597 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 565655009598 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 565655009599 Walker A/P-loop; other site 565655009600 ATP binding site [chemical binding]; other site 565655009601 Q-loop/lid; other site 565655009602 ABC transporter signature motif; other site 565655009603 Walker B; other site 565655009604 D-loop; other site 565655009605 H-loop/switch region; other site 565655009606 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 565655009607 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 565655009608 substrate binding pocket [chemical binding]; other site 565655009609 membrane-bound complex binding site; other site 565655009610 hinge residues; other site 565655009611 DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402 565655009612 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 565655009613 ligand binding site [chemical binding]; other site 565655009614 flexible hinge region; other site 565655009615 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 565655009616 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 565655009617 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 565655009618 active site turn [active] 565655009619 phosphorylation site [posttranslational modification] 565655009620 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 565655009621 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 565655009622 HPr interaction site; other site 565655009623 glycerol kinase (GK) interaction site [polypeptide binding]; other site 565655009624 active site 565655009625 phosphorylation site [posttranslational modification] 565655009626 transcriptional antiterminator BglG; Provisional; Region: PRK09772 565655009627 CAT RNA binding domain; Region: CAT_RBD; smart01061 565655009628 PRD domain; Region: PRD; pfam00874 565655009629 PRD domain; Region: PRD; pfam00874 565655009630 Predicted permeases [General function prediction only]; Region: RarD; COG2962 565655009631 EamA-like transporter family; Region: EamA; cl17759 565655009632 Major Facilitator Superfamily; Region: MFS_1; pfam07690 565655009633 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 565655009634 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 565655009635 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 565655009636 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 565655009637 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 565655009638 FMN binding site [chemical binding]; other site 565655009639 active site 565655009640 catalytic residues [active] 565655009641 substrate binding site [chemical binding]; other site 565655009642 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 565655009643 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cd11523 565655009644 metal binding site [ion binding]; metal-binding site 565655009645 hypothetical protein; Provisional; Region: PRK11615 565655009646 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 565655009647 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 565655009648 intersubunit interface [polypeptide binding]; other site 565655009649 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 565655009650 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 565655009651 Walker A/P-loop; other site 565655009652 ATP binding site [chemical binding]; other site 565655009653 Q-loop/lid; other site 565655009654 ABC transporter signature motif; other site 565655009655 Walker B; other site 565655009656 D-loop; other site 565655009657 H-loop/switch region; other site 565655009658 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 565655009659 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 565655009660 ABC-ATPase subunit interface; other site 565655009661 dimer interface [polypeptide binding]; other site 565655009662 putative PBP binding regions; other site 565655009663 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 565655009664 homopentamer interface [polypeptide binding]; other site 565655009665 active site 565655009666 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 565655009667 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 565655009668 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 565655009669 dimerization interface [polypeptide binding]; other site 565655009670 active site 565655009671 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 565655009672 Lumazine binding domain; Region: Lum_binding; pfam00677 565655009673 Lumazine binding domain; Region: Lum_binding; pfam00677 565655009674 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 565655009675 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 565655009676 catalytic motif [active] 565655009677 Zn binding site [ion binding]; other site 565655009678 RibD C-terminal domain; Region: RibD_C; cl17279 565655009679 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 565655009680 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 565655009681 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 565655009682 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 565655009683 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 565655009684 B12 binding site [chemical binding]; other site 565655009685 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 565655009686 motif II; other site 565655009687 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 565655009688 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 565655009689 NADH(P)-binding; Region: NAD_binding_10; pfam13460 565655009690 NAD(P) binding site [chemical binding]; other site 565655009691 putative active site [active] 565655009692 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 565655009693 Sodium Bile acid symporter family; Region: SBF; cl17470 565655009694 Glycerol dehydrogenase-like; Region: GlyDH-like2; cd08171 565655009695 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 565655009696 putative active site [active] 565655009697 metal binding site [ion binding]; metal-binding site 565655009698 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 565655009699 putative FMN binding site [chemical binding]; other site 565655009700 NADPH bind site [chemical binding]; other site 565655009701 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 565655009702 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 565655009703 DNA binding residues [nucleotide binding] 565655009704 putative dimer interface [polypeptide binding]; other site 565655009705 classical (c) SDRs; Region: SDR_c; cd05233 565655009706 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK06550 565655009707 NAD(P) binding site [chemical binding]; other site 565655009708 active site 565655009709 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 565655009710 classical (c) SDRs; Region: SDR_c; cd05233 565655009711 NAD(P) binding site [chemical binding]; other site 565655009712 active site 565655009713 SAM (Sterile alpha motif ); Region: SAM_superfamily; cl15755 565655009714 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 565655009715 putative efflux protein, MATE family; Region: matE; TIGR00797 565655009716 Uncharacterized protein YrkD from Bacillus subtilis and related domains; this domain superfamily was previously known as part of DUF156; Region: BsYrkD-like_DUF156; cd10155 565655009717 putative homodimer interface [polypeptide binding]; other site 565655009718 putative homotetramer interface [polypeptide binding]; other site 565655009719 putative metal binding site [ion binding]; other site 565655009720 putative homodimer-homodimer interface [polypeptide binding]; other site 565655009721 putative allosteric switch controlling residues; other site 565655009722 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 565655009723 active site residue [active] 565655009724 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 565655009725 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 565655009726 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 565655009727 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 565655009728 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 565655009729 active site residue [active] 565655009730 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 565655009731 active site residue [active] 565655009732 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 565655009733 non-specific DNA binding site [nucleotide binding]; other site 565655009734 salt bridge; other site 565655009735 sequence-specific DNA binding site [nucleotide binding]; other site 565655009736 Protein of unknown function (DUF3955); Region: DUF3955; pfam13127 565655009737 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 565655009738 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 565655009739 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 565655009740 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 565655009741 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 565655009742 Protein of unknown function (DUF2512); Region: DUF2512; pfam10710 565655009743 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 565655009744 DNA photolyase; Region: DNA_photolyase; pfam00875 565655009745 Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976 565655009746 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 565655009747 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 565655009748 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 565655009749 non-specific DNA binding site [nucleotide binding]; other site 565655009750 salt bridge; other site 565655009751 sequence-specific DNA binding site [nucleotide binding]; other site 565655009752 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 565655009753 Mga helix-turn-helix domain; Region: Mga; pfam05043 565655009754 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 565655009755 L-tyrosine decarboxylase; Provisional; Region: PRK13520 565655009756 pyridoxal 5'-phosphate binding site [chemical binding]; other site 565655009757 catalytic residue [active] 565655009758 glutamate:gamma-aminobutyrate antiporter; Region: 2A0307_GadC; TIGR00910 565655009759 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 565655009760 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 565655009761 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 565655009762 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 565655009763 DNA binding residues [nucleotide binding] 565655009764 putative dimer interface [polypeptide binding]; other site 565655009765 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 565655009766 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 565655009767 active site 565655009768 catalytic tetrad [active] 565655009769 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 565655009770 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 565655009771 putative NAD(P) binding site [chemical binding]; other site 565655009772 Predicted transcriptional regulators [Transcription]; Region: COG1733 565655009773 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 565655009774 CAAX protease self-immunity; Region: Abi; pfam02517 565655009775 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 565655009776 non-specific DNA binding site [nucleotide binding]; other site 565655009777 salt bridge; other site 565655009778 sequence-specific DNA binding site [nucleotide binding]; other site 565655009779 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 565655009780 beta-galactosidase; Region: BGL; TIGR03356 565655009781 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 565655009782 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 565655009783 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 565655009784 active site 565655009785 P-loop; other site 565655009786 phosphorylation site [posttranslational modification] 565655009787 PTS system, Lactose/Cellobiose specific IIA subunit; Region: PTS_IIA; pfam02255 565655009788 active site 565655009789 methionine cluster; other site 565655009790 phosphorylation site [posttranslational modification] 565655009791 metal binding site [ion binding]; metal-binding site 565655009792 MucBP domain; Region: MucBP; pfam06458 565655009793 MucBP domain; Region: MucBP; pfam06458 565655009794 MucBP domain; Region: MucBP; pfam06458 565655009795 MucBP domain; Region: MucBP; pfam06458 565655009796 MucBP domain; Region: MucBP; pfam06458 565655009797 MucBP domain; Region: MucBP; pfam06458 565655009798 Transcriptional regulator [Transcription]; Region: LysR; COG0583 565655009799 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 565655009800 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 565655009801 dimerization interface [polypeptide binding]; other site 565655009802 malate dehydrogenase; Provisional; Region: PRK13529 565655009803 Malic enzyme, N-terminal domain; Region: malic; pfam00390 565655009804 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 565655009805 NAD(P) binding site [chemical binding]; other site 565655009806 2-hydroxycarboxylate transporter family; Region: 2HCT; pfam03390 565655009807 Chitin binding domain; Region: Chitin_bind_3; pfam03067 565655009808 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 565655009809 Interdomain contacts; other site 565655009810 Cytokine receptor motif; other site 565655009811 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 565655009812 Interdomain contacts; other site 565655009813 Cytokine receptor motif; other site 565655009814 Chitin/cellulose binding domains of chitinase and related enzymes; Region: ChtBD3; cl00046 565655009815 aromatic chitin/cellulose binding site residues [chemical binding]; other site 565655009816 fumarate reductase flavoprotein subunit; Validated; Region: PRK06481 565655009817 L-aspartate oxidase; Provisional; Region: PRK06175 565655009818 phosphate-starvation-inducible protein PsiE; Provisional; Region: PRK02833 565655009819 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 565655009820 dimer interface [polypeptide binding]; other site 565655009821 phosphorylation site [posttranslational modification] 565655009822 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 565655009823 ATP binding site [chemical binding]; other site 565655009824 Mg2+ binding site [ion binding]; other site 565655009825 G-X-G motif; other site 565655009826 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 565655009827 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 565655009828 active site 565655009829 phosphorylation site [posttranslational modification] 565655009830 intermolecular recognition site; other site 565655009831 dimerization interface [polypeptide binding]; other site 565655009832 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 565655009833 DNA binding site [nucleotide binding] 565655009834 ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; cl00768 565655009835 Transcriptional regulators [Transcription]; Region: GntR; COG1802 565655009836 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 565655009837 DNA-binding site [nucleotide binding]; DNA binding site 565655009838 FCD domain; Region: FCD; pfam07729 565655009839 H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851 565655009840 Citrate transporter; Region: CitMHS; pfam03600 565655009841 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06549 565655009842 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 565655009843 carboxyltransferase (CT) interaction site; other site 565655009844 biotinylation site [posttranslational modification]; other site 565655009845 Na+-transporting oxaloacetate decarboxylase beta subunit; Region: OAD_beta; pfam03977 565655009846 Citrate lyase synthetase [Energy production and conversion]; Region: CitC; COG3053 565655009847 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 565655009848 active site 565655009849 nucleotide binding site [chemical binding]; other site 565655009850 HIGH motif; other site 565655009851 KMSKS motif; other site 565655009852 citrate lyase subunit gamma; Provisional; Region: PRK13253 565655009853 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 565655009854 Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051 565655009855 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 565655009856 Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase; Region: CitX; cl01498 565655009857 oxaloacetate decarboxylase; Provisional; Region: PRK12331 565655009858 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 565655009859 active site 565655009860 catalytic residues [active] 565655009861 metal binding site [ion binding]; metal-binding site 565655009862 homodimer binding site [polypeptide binding]; other site 565655009863 Protein of unknown function (DUF1697); Region: DUF1697; pfam08002 565655009864 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 565655009865 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 565655009866 nucleotide binding site [chemical binding]; other site 565655009867 Transcriptional regulators [Transcription]; Region: PurR; COG1609 565655009868 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 565655009869 DNA binding site [nucleotide binding] 565655009870 domain linker motif; other site 565655009871 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 565655009872 dimerization interface [polypeptide binding]; other site 565655009873 ligand binding site [chemical binding]; other site 565655009874 sodium binding site [ion binding]; other site 565655009875 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 565655009876 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 565655009877 substrate binding [chemical binding]; other site 565655009878 active site 565655009879 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 565655009880 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 565655009881 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 565655009882 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 565655009883 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 565655009884 dimer interface [polypeptide binding]; other site 565655009885 conserved gate region; other site 565655009886 ABC-ATPase subunit interface; other site 565655009887 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 565655009888 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 565655009889 ABC-ATPase subunit interface; other site 565655009890 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 565655009891 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 565655009892 dimer interface [polypeptide binding]; other site 565655009893 conserved gate region; other site 565655009894 putative PBP binding loops; other site 565655009895 ABC-ATPase subunit interface; other site 565655009896 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 565655009897 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 565655009898 dimer interface [polypeptide binding]; other site 565655009899 conserved gate region; other site 565655009900 putative PBP binding loops; other site 565655009901 ABC-ATPase subunit interface; other site 565655009902 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 565655009903 cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340 565655009904 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 565655009905 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 565655009906 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 565655009907 Beta galactosidase small chain; Region: Bgal_small_N; smart01038 565655009908 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 565655009909 non-specific DNA binding site [nucleotide binding]; other site 565655009910 salt bridge; other site 565655009911 sequence-specific DNA binding site [nucleotide binding]; other site 565655009912 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 565655009913 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 565655009914 non-specific DNA binding site [nucleotide binding]; other site 565655009915 salt bridge; other site 565655009916 sequence-specific DNA binding site [nucleotide binding]; other site 565655009917 Catalytic domain of type II restriction endonucleases BfiI and NgoFVII, and uncharacterized proteins with a DEAD domain; Region: PLDc_Bfil_DEXD_like; cd09117 565655009918 homodimer interface [polypeptide binding]; other site 565655009919 putative active site [active] 565655009920 catalytic site [active] 565655009921 DNA-methyltransferase (dcm); Region: dcm; TIGR00675 565655009922 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 565655009923 cofactor binding site; other site 565655009924 DNA binding site [nucleotide binding] 565655009925 substrate interaction site [chemical binding]; other site 565655009926 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 565655009927 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 565655009928 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 565655009929 cofactor binding site; other site 565655009930 DNA binding site [nucleotide binding] 565655009931 substrate interaction site [chemical binding]; other site 565655009932 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 565655009933 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 565655009934 non-specific DNA binding site [nucleotide binding]; other site 565655009935 salt bridge; other site 565655009936 sequence-specific DNA binding site [nucleotide binding]; other site 565655009937 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 565655009938 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 565655009939 23S rRNA interface [nucleotide binding]; other site 565655009940 L3 interface [polypeptide binding]; other site 565655009941 argininosuccinate synthase; Provisional; Region: PRK13820 565655009942 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 565655009943 ANP binding site [chemical binding]; other site 565655009944 Substrate Binding Site II [chemical binding]; other site 565655009945 Substrate Binding Site I [chemical binding]; other site 565655009946 argininosuccinate lyase; Provisional; Region: PRK00855 565655009947 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 565655009948 active sites [active] 565655009949 tetramer interface [polypeptide binding]; other site 565655009950 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 565655009951 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 565655009952 dimerization interface [polypeptide binding]; other site 565655009953 DPS ferroxidase diiron center [ion binding]; other site 565655009954 ion pore; other site 565655009955 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 565655009956 Collagen binding domain; Region: Collagen_bind; pfam05737 565655009957 streptococcal pilin isopeptide linkage domain; Region: strep_pil_rpt; TIGR03786 565655009958 T surface-antigen of pili; Region: FctA; pfam12892 565655009959 T surface-antigen of pili; Region: FctA; pfam12892 565655009960 streptococcal pilin isopeptide linkage domain; Region: strep_pil_rpt; TIGR03786 565655009961 T surface-antigen of pili; Region: FctA; pfam12892 565655009962 streptococcal pilin isopeptide linkage domain; Region: strep_pil_rpt; TIGR03786 565655009963 streptococcal pilin isopeptide linkage domain; Region: strep_pil_rpt; TIGR03786 565655009964 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 565655009965 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 565655009966 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 565655009967 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 565655009968 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 565655009969 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 565655009970 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 565655009971 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 565655009972 DNA binding site [nucleotide binding] 565655009973 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 565655009974 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 565655009975 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 565655009976 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 565655009977 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 565655009978 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 565655009979 RPB1 interaction site [polypeptide binding]; other site 565655009980 RPB10 interaction site [polypeptide binding]; other site 565655009981 RPB11 interaction site [polypeptide binding]; other site 565655009982 RPB3 interaction site [polypeptide binding]; other site 565655009983 RPB12 interaction site [polypeptide binding]; other site 565655009984 Biotin operon repressor [Transcription]; Region: BirA; COG1654 565655009985 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 565655009986 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 565655009987 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 565655009988 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Provisional; Region: PRK13387 565655009989 UbiA prenyltransferase family; Region: UbiA; pfam01040 565655009990 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 565655009991 ApbE family; Region: ApbE; pfam02424 565655009992 This conserved region includes the FMN-binding site of the NqrC protein as well as the NosR and NirI regulatory proteins; Region: FMN_bind; smart00900 565655009993 Major membrane immunogen, membrane-anchored lipoprotein [Function unknown]; Region: COG4939 565655009994 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 565655009995 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 565655009996 Listerrria innocua Lin0431 is similar to the N-Utilization Substance G (NusG) N terminal (NGN) insert (DII); Region: Lin0431_like; cd09911 565655009997 trimer interface [polypeptide binding]; other site 565655009998 Heptaprenyl diphosphate synthase component I; Region: Hpre_diP_synt_I; pfam07456 565655009999 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 565655010000 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 565655010001 substrate binding pocket [chemical binding]; other site 565655010002 chain length determination region; other site 565655010003 substrate-Mg2+ binding site; other site 565655010004 catalytic residues [active] 565655010005 aspartate-rich region 1; other site 565655010006 active site lid residues [active] 565655010007 aspartate-rich region 2; other site 565655010008 glutathione reductase; Validated; Region: PRK06116 565655010009 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 565655010010 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 565655010011 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 565655010012 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 565655010013 Peptidase family U32; Region: Peptidase_U32; pfam01136 565655010014 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 565655010015 Peptidase family U32; Region: Peptidase_U32; pfam01136 565655010016 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 565655010017 Clp amino terminal domain; Region: Clp_N; pfam02861 565655010018 Clp amino terminal domain; Region: Clp_N; pfam02861 565655010019 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 565655010020 Walker A motif; other site 565655010021 ATP binding site [chemical binding]; other site 565655010022 Walker B motif; other site 565655010023 arginine finger; other site 565655010024 UvrB/uvrC motif; Region: UVR; pfam02151 565655010025 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 565655010026 Walker A motif; other site 565655010027 ATP binding site [chemical binding]; other site 565655010028 Walker B motif; other site 565655010029 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 565655010030 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848 565655010031 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 565655010032 Catalytic domain of Protein Kinases; Region: PKc; cd00180 565655010033 active site 565655010034 ATP binding site [chemical binding]; other site 565655010035 substrate binding site [chemical binding]; other site 565655010036 activation loop (A-loop); other site 565655010037 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 565655010038 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 565655010039 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 565655010040 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 565655010041 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 565655010042 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 565655010043 active site 565655010044 16S rRNA methyltransferase B; Provisional; Region: PRK14902 565655010045 NusB family; Region: NusB; pfam01029 565655010046 putative RNA binding site [nucleotide binding]; other site 565655010047 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 565655010048 S-adenosylmethionine binding site [chemical binding]; other site 565655010049 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 565655010050 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 565655010051 putative active site [active] 565655010052 substrate binding site [chemical binding]; other site 565655010053 putative cosubstrate binding site; other site 565655010054 catalytic site [active] 565655010055 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 565655010056 substrate binding site [chemical binding]; other site 565655010057 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 565655010058 active site 565655010059 catalytic residues [active] 565655010060 metal binding site [ion binding]; metal-binding site 565655010061 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 565655010062 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 565655010063 ATP binding site [chemical binding]; other site 565655010064 putative Mg++ binding site [ion binding]; other site 565655010065 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 565655010066 nucleotide binding region [chemical binding]; other site 565655010067 ATP-binding site [chemical binding]; other site 565655010068 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 565655010069 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 565655010070 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 565655010071 catalytic site [active] 565655010072 G-X2-G-X-G-K; other site 565655010073 hypothetical protein; Provisional; Region: PRK11820 565655010074 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 565655010075 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 565655010076 Uncharacterized protein conserved in bacteria (DUF2128); Region: DUF2128; pfam09901 565655010077 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 565655010078 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 565655010079 active site 565655010080 nucleophile elbow; other site 565655010081 Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165 565655010082 active site 565655010083 catalytic site [active] 565655010084 Thiamine transporter protein (Thia_YuaJ); Region: Thia_YuaJ; pfam09515 565655010085 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 565655010086 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 565655010087 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 565655010088 active site 565655010089 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 565655010090 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 565655010091 Substrate binding site; other site 565655010092 Mg++ binding site; other site 565655010093 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 565655010094 active site 565655010095 substrate binding site [chemical binding]; other site 565655010096 CoA binding site [chemical binding]; other site 565655010097 pur operon repressor; Provisional; Region: PRK09213 565655010098 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 565655010099 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 565655010100 active site 565655010101 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 565655010102 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 565655010103 ABC-ATPase subunit interface; other site 565655010104 dimer interface [polypeptide binding]; other site 565655010105 putative PBP binding regions; other site 565655010106 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 565655010107 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 565655010108 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 565655010109 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 565655010110 metal binding site [ion binding]; metal-binding site 565655010111 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 565655010112 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 565655010113 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 565655010114 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 565655010115 Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471 565655010116 putative dimer interface [polypeptide binding]; other site 565655010117 intracellular protease, PfpI family; Region: PfpI; TIGR01382 565655010118 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 565655010119 proposed catalytic triad [active] 565655010120 conserved cys residue [active] 565655010121 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 565655010122 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 565655010123 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 565655010124 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 565655010125 active site 565655010126 phosphorylation site [posttranslational modification] 565655010127 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 565655010128 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 565655010129 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 565655010130 active site 565655010131 P-loop; other site 565655010132 phosphorylation site [posttranslational modification] 565655010133 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 565655010134 active site 565655010135 P-loop; other site 565655010136 phosphorylation site [posttranslational modification] 565655010137 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 565655010138 active site 565655010139 phosphorylation site [posttranslational modification] 565655010140 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 565655010141 HTH domain; Region: HTH_11; cl17392 565655010142 PRD domain; Region: PRD; pfam00874 565655010143 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 565655010144 active site 565655010145 P-loop; other site 565655010146 phosphorylation site [posttranslational modification] 565655010147 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 565655010148 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 565655010149 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 565655010150 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 565655010151 active site 565655010152 P-loop; other site 565655010153 phosphorylation site [posttranslational modification] 565655010154 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 565655010155 Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; Region: SPEC; cl02488 565655010156 linker region; other site 565655010157 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 565655010158 NlpC/P60 family; Region: NLPC_P60; pfam00877 565655010159 rod shape-determining protein MreD; Region: MreD; cl01087 565655010160 rod shape-determining protein MreC; Provisional; Region: PRK13922 565655010161 rod shape-determining protein MreC; Region: MreC; pfam04085 565655010162 Thiamine pyrophosphokinase; Region: TPK; cd07995 565655010163 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 565655010164 active site 565655010165 dimerization interface [polypeptide binding]; other site 565655010166 thiamine binding site [chemical binding]; other site 565655010167 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 565655010168 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 565655010169 substrate binding site [chemical binding]; other site 565655010170 hexamer interface [polypeptide binding]; other site 565655010171 metal binding site [ion binding]; metal-binding site 565655010172 GTPase RsgA; Reviewed; Region: PRK00098 565655010173 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 565655010174 RNA binding site [nucleotide binding]; other site 565655010175 homodimer interface [polypeptide binding]; other site 565655010176 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 565655010177 GTPase/Zn-binding domain interface [polypeptide binding]; other site 565655010178 GTP/Mg2+ binding site [chemical binding]; other site 565655010179 G4 box; other site 565655010180 G5 box; other site 565655010181 G1 box; other site 565655010182 Switch I region; other site 565655010183 G2 box; other site 565655010184 G3 box; other site 565655010185 Switch II region; other site 565655010186 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 565655010187 Transposase; Region: DDE_Tnp_ISL3; pfam01610 565655010188 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 565655010189 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 565655010190 active site 565655010191 phosphorylation site [posttranslational modification] 565655010192 intermolecular recognition site; other site 565655010193 dimerization interface [polypeptide binding]; other site 565655010194 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 565655010195 DNA binding site [nucleotide binding] 565655010196 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 565655010197 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 565655010198 dimer interface [polypeptide binding]; other site 565655010199 phosphorylation site [posttranslational modification] 565655010200 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 565655010201 ATP binding site [chemical binding]; other site 565655010202 Mg2+ binding site [ion binding]; other site 565655010203 G-X-G motif; other site 565655010204 seryl-tRNA synthetase; Provisional; Region: PRK05431 565655010205 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 565655010206 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 565655010207 dimer interface [polypeptide binding]; other site 565655010208 active site 565655010209 motif 1; other site 565655010210 motif 2; other site 565655010211 motif 3; other site 565655010212 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 565655010213 Catalytic NodB homology domain of Clostridium thermocellum acetylxylan esterase and its bacterial homologs; Region: CE4_CtAXE_like; cd10954 565655010214 NodB motif; other site 565655010215 active site 565655010216 catalytic site [active] 565655010217 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 565655010218 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 565655010219 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 565655010220 Walker A/P-loop; other site 565655010221 ATP binding site [chemical binding]; other site 565655010222 Q-loop/lid; other site 565655010223 ABC transporter signature motif; other site 565655010224 Walker B; other site 565655010225 D-loop; other site 565655010226 H-loop/switch region; other site 565655010227 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 565655010228 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 565655010229 FtsX-like permease family; Region: FtsX; pfam02687 565655010230 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 565655010231 FtsX-like permease family; Region: FtsX; pfam02687 565655010232 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 565655010233 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 565655010234 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 565655010235 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 565655010236 active site 565655010237 Protein of unknown function (DUF1129); Region: DUF1129; pfam06570 565655010238 GTP-binding protein YchF; Reviewed; Region: PRK09601 565655010239 YchF GTPase; Region: YchF; cd01900 565655010240 G1 box; other site 565655010241 GTP/Mg2+ binding site [chemical binding]; other site 565655010242 Switch I region; other site 565655010243 G2 box; other site 565655010244 Switch II region; other site 565655010245 G3 box; other site 565655010246 G4 box; other site 565655010247 G5 box; other site 565655010248 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 565655010249 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 565655010250 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 565655010251 ParB-like nuclease domain; Region: ParBc; pfam02195 565655010252 KorB domain; Region: KorB; pfam08535 565655010253 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 565655010254 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 565655010255 P-loop; other site 565655010256 Magnesium ion binding site [ion binding]; other site 565655010257 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 565655010258 Magnesium ion binding site [ion binding]; other site 565655010259 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 565655010260 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 565655010261 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 565655010262 oxidoreductase; Provisional; Region: PRK07985 565655010263 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 565655010264 NAD(P) binding site [chemical binding]; other site 565655010265 active site 565655010266 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4876 565655010267 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 565655010268 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 565655010269 non-specific DNA binding site [nucleotide binding]; other site 565655010270 salt bridge; other site 565655010271 sequence-specific DNA binding site [nucleotide binding]; other site 565655010272 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 565655010273 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 565655010274 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 565655010275 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 565655010276 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 565655010277 trmE is a tRNA modification GTPase; Region: trmE; cd04164 565655010278 G1 box; other site 565655010279 GTP/Mg2+ binding site [chemical binding]; other site 565655010280 Switch I region; other site 565655010281 G2 box; other site 565655010282 Switch II region; other site 565655010283 G3 box; other site 565655010284 G4 box; other site 565655010285 G5 box; other site 565655010286 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 565655010287 Putative heavy-metal-binding; Region: YbjQ_1; pfam01906 565655010288 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 565655010289 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 565655010290 G-X-X-G motif; other site 565655010291 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 565655010292 RxxxH motif; other site 565655010293 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 565655010294 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 565655010295 ribonuclease P; Reviewed; Region: rnpA; PRK00499 565655010296 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399