-- dump date 20140619_073955 -- class Genbank::misc_feature -- table misc_feature_note -- id note 474186000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 474186000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 474186000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 474186000004 Walker A motif; other site 474186000005 ATP binding site [chemical binding]; other site 474186000006 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 474186000007 Walker B motif; other site 474186000008 arginine finger; other site 474186000009 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 474186000010 DnaA box-binding interface [nucleotide binding]; other site 474186000011 DNA polymerase III subunit beta; Validated; Region: PRK05643 474186000012 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 474186000013 putative DNA binding surface [nucleotide binding]; other site 474186000014 dimer interface [polypeptide binding]; other site 474186000015 beta-clamp/clamp loader binding surface; other site 474186000016 beta-clamp/translesion DNA polymerase binding surface; other site 474186000017 S4 domain protein YaaA; Region: YaaA_near_RecF; TIGR02988 474186000018 recombination protein F; Reviewed; Region: recF; PRK00064 474186000019 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 474186000020 Walker A/P-loop; other site 474186000021 ATP binding site [chemical binding]; other site 474186000022 Q-loop/lid; other site 474186000023 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 474186000024 ABC transporter signature motif; other site 474186000025 Walker B; other site 474186000026 D-loop; other site 474186000027 H-loop/switch region; other site 474186000028 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 474186000029 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 474186000030 Mg2+ binding site [ion binding]; other site 474186000031 G-X-G motif; other site 474186000032 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 474186000033 anchoring element; other site 474186000034 dimer interface [polypeptide binding]; other site 474186000035 ATP binding site [chemical binding]; other site 474186000036 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 474186000037 active site 474186000038 putative metal-binding site [ion binding]; other site 474186000039 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 474186000040 DNA gyrase subunit A; Validated; Region: PRK05560 474186000041 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 474186000042 CAP-like domain; other site 474186000043 active site 474186000044 primary dimer interface [polypeptide binding]; other site 474186000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 474186000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 474186000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 474186000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 474186000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 474186000050 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 474186000051 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 474186000052 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 474186000053 dimer interface [polypeptide binding]; other site 474186000054 ssDNA binding site [nucleotide binding]; other site 474186000055 tetramer (dimer of dimers) interface [polypeptide binding]; other site 474186000056 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 474186000057 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 474186000058 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 474186000059 DHH family; Region: DHH; pfam01368 474186000060 DHHA1 domain; Region: DHHA1; pfam02272 474186000061 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 474186000062 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 474186000063 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 474186000064 replicative DNA helicase; Provisional; Region: PRK05748 474186000065 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 474186000066 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 474186000067 Walker A motif; other site 474186000068 ATP binding site [chemical binding]; other site 474186000069 Walker B motif; other site 474186000070 DNA binding loops [nucleotide binding] 474186000071 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 474186000072 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 474186000073 GDP-binding site [chemical binding]; other site 474186000074 ACT binding site; other site 474186000075 IMP binding site; other site 474186000076 EDD domain protein, DegV family; Region: DegV; TIGR00762 474186000077 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 474186000078 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 474186000079 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 474186000080 Walker A/P-loop; other site 474186000081 ATP binding site [chemical binding]; other site 474186000082 Q-loop/lid; other site 474186000083 ABC transporter signature motif; other site 474186000084 Walker B; other site 474186000085 D-loop; other site 474186000086 H-loop/switch region; other site 474186000087 ABC transporter; Region: ABC_tran_2; pfam12848 474186000088 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 474186000089 Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775 474186000090 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 474186000091 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 474186000092 Walker A motif; other site 474186000093 ATP binding site [chemical binding]; other site 474186000094 Walker B motif; other site 474186000095 arginine finger; other site 474186000096 Transcriptional antiterminator [Transcription]; Region: COG3933 474186000097 PRD domain; Region: PRD; pfam00874 474186000098 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 474186000099 active pocket/dimerization site; other site 474186000100 active site 474186000101 phosphorylation site [posttranslational modification] 474186000102 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cd00133 474186000103 active site 474186000104 P-loop; other site 474186000105 phosphorylation site [posttranslational modification] 474186000106 PRD domain; Region: PRD; pfam00874 474186000107 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 474186000108 active site 474186000109 phosphorylation site [posttranslational modification] 474186000110 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 474186000111 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 474186000112 active pocket/dimerization site; other site 474186000113 active site 474186000114 phosphorylation site [posttranslational modification] 474186000115 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 474186000116 active site 474186000117 phosphorylation site [posttranslational modification] 474186000118 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 474186000119 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 474186000120 Domain of unknown function (DUF956); Region: DUF956; pfam06115 474186000121 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 474186000122 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 474186000123 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 474186000124 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 474186000125 putative active site [active] 474186000126 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 474186000127 PTS system, maltose and glucose-specific IIBC component; Region: PTS-IIBC-malX; TIGR02004 474186000128 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 474186000129 active site turn [active] 474186000130 phosphorylation site [posttranslational modification] 474186000131 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 474186000132 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 474186000133 pyridoxal 5'-phosphate binding site [chemical binding]; other site 474186000134 homodimer interface [polypeptide binding]; other site 474186000135 catalytic residue [active] 474186000136 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 474186000137 homotrimer interaction site [polypeptide binding]; other site 474186000138 putative active site [active] 474186000139 Predicted integral membrane protein [Function unknown]; Region: COG0392 474186000140 Uncharacterized conserved protein [Function unknown]; Region: COG2898 474186000141 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 474186000142 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 474186000143 Protein of unknown function (DUF1706); Region: DUF1706; pfam08020 474186000144 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 474186000145 dimer interface [polypeptide binding]; other site 474186000146 Predicted transcriptional regulator [Transcription]; Region: COG2378 474186000147 HTH domain; Region: HTH_11; pfam08279 474186000148 WYL domain; Region: WYL; pfam13280 474186000149 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 474186000150 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 474186000151 putative catalytic cysteine [active] 474186000152 Glutamate 5-kinase [Amino acid transport and metabolism]; Region: ProB; COG0263 474186000153 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 474186000154 nucleotide binding site [chemical binding]; other site 474186000155 homotetrameric interface [polypeptide binding]; other site 474186000156 putative phosphate binding site [ion binding]; other site 474186000157 putative allosteric binding site; other site 474186000158 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 474186000159 trimer interface [polypeptide binding]; other site 474186000160 active site 474186000161 DNA repair protein RadA; Provisional; Region: PRK11823 474186000162 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 474186000163 Walker A motif/ATP binding site; other site 474186000164 ATP binding site [chemical binding]; other site 474186000165 Walker B motif; other site 474186000166 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 474186000167 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 474186000168 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 474186000169 putative active site [active] 474186000170 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 474186000171 homotrimer interaction site [polypeptide binding]; other site 474186000172 zinc binding site [ion binding]; other site 474186000173 CDP-binding sites; other site 474186000174 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 474186000175 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 474186000176 HIGH motif; other site 474186000177 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 474186000178 active site 474186000179 KMSKS motif; other site 474186000180 serine O-acetyltransferase; Region: cysE; TIGR01172 474186000181 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 474186000182 trimer interface [polypeptide binding]; other site 474186000183 active site 474186000184 substrate binding site [chemical binding]; other site 474186000185 CoA binding site [chemical binding]; other site 474186000186 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 474186000187 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 474186000188 active site 474186000189 HIGH motif; other site 474186000190 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 474186000191 KMSKS motif; other site 474186000192 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 474186000193 tRNA binding surface [nucleotide binding]; other site 474186000194 anticodon binding site; other site 474186000195 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 474186000196 active site 474186000197 metal binding site [ion binding]; metal-binding site 474186000198 dimerization interface [polypeptide binding]; other site 474186000199 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 474186000200 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 474186000201 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 474186000202 YacP-like NYN domain; Region: NYN_YacP; pfam05991 474186000203 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 474186000204 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 474186000205 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 474186000206 DNA binding residues [nucleotide binding] 474186000207 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 474186000208 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 474186000209 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 474186000210 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 474186000211 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 474186000212 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 474186000213 metal binding site [ion binding]; metal-binding site 474186000214 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 474186000215 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 474186000216 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 474186000217 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 474186000218 ABC-ATPase subunit interface; other site 474186000219 dimer interface [polypeptide binding]; other site 474186000220 putative PBP binding regions; other site 474186000221 pur operon repressor; Provisional; Region: PRK09213 474186000222 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 474186000223 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 474186000224 active site 474186000225 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 474186000226 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 474186000227 Substrate binding site; other site 474186000228 Mg++ binding site; other site 474186000229 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 474186000230 active site 474186000231 substrate binding site [chemical binding]; other site 474186000232 CoA binding site [chemical binding]; other site 474186000233 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase precursor protein; Reviewed; Region: PRK09419 474186000234 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 474186000235 active site 474186000236 metal binding site [ion binding]; metal-binding site 474186000237 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 474186000238 Staphylococcus aureus SA0022 and related proteins, N-terminal metallophosphatase domain; Region: MPP_SA0022_N; cd07408 474186000239 putative active site [active] 474186000240 putative metal binding site [ion binding]; other site 474186000241 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 474186000242 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 474186000243 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 474186000244 peptide binding site [polypeptide binding]; other site 474186000245 Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979 474186000246 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 474186000247 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 474186000248 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 474186000249 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 474186000250 RuvA N terminal domain; Region: RuvA_N; pfam01330 474186000251 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 474186000252 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 474186000253 Walker A motif; other site 474186000254 ATP binding site [chemical binding]; other site 474186000255 Walker B motif; other site 474186000256 arginine finger; other site 474186000257 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 474186000258 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 474186000259 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 474186000260 putative active site cavity [active] 474186000261 alpha-glucosidase; Provisional; Region: PRK10137 474186000262 Protein of unknown function, DUF608; Region: DUF608; pfam04685 474186000263 Trehalase; Region: Trehalase; cl17346 474186000264 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 474186000265 non-specific DNA binding site [nucleotide binding]; other site 474186000266 salt bridge; other site 474186000267 sequence-specific DNA binding site [nucleotide binding]; other site 474186000268 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 474186000269 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 474186000270 ligand binding site [chemical binding]; other site 474186000271 flexible hinge region; other site 474186000272 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 474186000273 oxidoreductase; Provisional; Region: PRK07985 474186000274 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 474186000275 NAD(P) binding site [chemical binding]; other site 474186000276 active site 474186000277 Small integral membrane protein (DUF2273); Region: DUF2273; cl11575 474186000278 Asp23 family; Region: Asp23; pfam03780 474186000279 Asp23 family; Region: Asp23; pfam03780 474186000280 Predicted membrane protein [Function unknown]; Region: COG2261 474186000281 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 474186000282 nucleophilic elbow; other site 474186000283 catalytic triad; other site 474186000284 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 474186000285 Major Facilitator Superfamily; Region: MFS_1; pfam07690 474186000286 putative substrate translocation pore; other site 474186000287 Mga helix-turn-helix domain; Region: Mga; pfam05043 474186000288 Mga helix-turn-helix domain; Region: Mga; pfam05043 474186000289 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 474186000290 Collagen binding domain; Region: Collagen_bind; pfam05737 474186000291 Collagen binding domain; Region: Collagen_bind; pfam05737 474186000292 Collagen binding domain; Region: Collagen_bind; pfam05737 474186000293 Collagen binding domain; Region: Collagen_bind; pfam05737 474186000294 Collagen binding domain; Region: Collagen_bind; pfam05737 474186000295 Cna protein B-type domain; Region: Cna_B; pfam05738 474186000296 Cna protein B-type domain; Region: Cna_B; pfam05738 474186000297 Cna protein B-type domain; Region: Cna_B; pfam05738 474186000298 Cna protein B-type domain; Region: Cna_B; pfam05738 474186000299 Cna protein B-type domain; Region: Cna_B; pfam05738 474186000300 Cna protein B-type domain; Region: Cna_B; pfam05738 474186000301 Cna protein B-type domain; Region: Cna_B; pfam05738 474186000302 Cna protein B-type domain; Region: Cna_B; pfam05738 474186000303 Cna protein B-type domain; Region: Cna_B; pfam05738 474186000304 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 474186000305 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 474186000306 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 474186000307 Mga helix-turn-helix domain; Region: Mga; pfam05043 474186000308 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 474186000309 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 474186000310 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 474186000311 YheO-like PAS domain; Region: PAS_6; pfam08348 474186000312 HTH domain; Region: HTH_22; pfam13309 474186000313 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425 474186000314 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 474186000315 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 474186000316 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 474186000317 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 474186000318 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 474186000319 seryl-tRNA synthetase; Provisional; Region: PRK05431 474186000320 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 474186000321 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 474186000322 dimer interface [polypeptide binding]; other site 474186000323 active site 474186000324 motif 1; other site 474186000325 motif 2; other site 474186000326 motif 3; other site 474186000327 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 474186000328 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 474186000329 Arginine repressor [Transcription]; Region: ArgR; COG1438 474186000330 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 474186000331 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 474186000332 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 474186000333 Arginine repressor [Transcription]; Region: ArgR; COG1438 474186000334 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 474186000335 arginine deiminase; Provisional; Region: PRK01388 474186000336 ornithine carbamoyltransferase; Validated; Region: PRK02102 474186000337 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 474186000338 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 474186000339 carbamate kinase; Reviewed; Region: PRK12686 474186000340 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 474186000341 putative substrate binding site [chemical binding]; other site 474186000342 nucleotide binding site [chemical binding]; other site 474186000343 nucleotide binding site [chemical binding]; other site 474186000344 homodimer interface [polypeptide binding]; other site 474186000345 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 474186000346 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 474186000347 ligand binding site [chemical binding]; other site 474186000348 flexible hinge region; other site 474186000349 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 474186000350 putative switch regulator; other site 474186000351 non-specific DNA interactions [nucleotide binding]; other site 474186000352 DNA binding site [nucleotide binding] 474186000353 sequence specific DNA binding site [nucleotide binding]; other site 474186000354 putative cAMP binding site [chemical binding]; other site 474186000355 Predicted membrane protein [Function unknown]; Region: COG1288 474186000356 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 474186000357 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 474186000358 potential catalytic triad [active] 474186000359 conserved cys residue [active] 474186000360 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 474186000361 dimerization interface [polypeptide binding]; other site 474186000362 putative DNA binding site [nucleotide binding]; other site 474186000363 putative Zn2+ binding site [ion binding]; other site 474186000364 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 474186000365 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 474186000366 putative NAD(P) binding site [chemical binding]; other site 474186000367 Endo-beta-N-acetylglucosaminidases are bacterial chitinases that hydrolyze the chitin core of various asparagine (N)-linked glycans and glycoproteins. The endo-beta-N-acetylglucosaminidases have a glycosyl hydrolase family 18 (GH18) catalytic domain; Region: GH18_EndoS-like; cd06542 474186000368 active site 474186000369 Glycosyl hydrolase family 20 (GH20) catalytic domain of dispersin B (DspB), lacto-N-biosidase (LnbB) and related proteins. Dispersin B is a soluble beta-N-acetylglucosamidase found in bacteria that hydrolyzes the beta-1,6-linkages of PGA (poly-beta-(1,6)...; Region: GH20_DspB_LnbB-like; cd06564 474186000370 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 474186000371 active site 474186000372 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 474186000373 homotrimer interaction site [polypeptide binding]; other site 474186000374 putative active site [active] 474186000375 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 474186000376 homotrimer interaction site [polypeptide binding]; other site 474186000377 putative active site [active] 474186000378 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 474186000379 homotrimer interaction site [polypeptide binding]; other site 474186000380 putative active site [active] 474186000381 MepB protein; Region: MepB; pfam08877 474186000382 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 474186000383 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 474186000384 DNA-binding site [nucleotide binding]; DNA binding site 474186000385 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 474186000386 pyridoxal 5'-phosphate binding site [chemical binding]; other site 474186000387 homodimer interface [polypeptide binding]; other site 474186000388 catalytic residue [active] 474186000389 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 474186000390 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 474186000391 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 474186000392 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; cl00920 474186000393 GMP synthase; Reviewed; Region: guaA; PRK00074 474186000394 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 474186000395 AMP/PPi binding site [chemical binding]; other site 474186000396 candidate oxyanion hole; other site 474186000397 catalytic triad [active] 474186000398 potential glutamine specificity residues [chemical binding]; other site 474186000399 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 474186000400 ATP Binding subdomain [chemical binding]; other site 474186000401 Dimerization subdomain; other site 474186000402 pantothenate kinase; Provisional; Region: PRK05439 474186000403 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 474186000404 ATP-binding site [chemical binding]; other site 474186000405 CoA-binding site [chemical binding]; other site 474186000406 Mg2+-binding site [ion binding]; other site 474186000407 Isoamyl-acetate hydrolyzing esterase-like proteins. SGNH_hydrolase subfamily similar to the Saccharomyces cerevisiae IAH1. IAH1 may be the major esterase that hydrolyses isoamyl acetate in sake mash. The SGNH-family of hydrolases is a diverse family of...; Region: Isoamyl_acetate_hydrolase_like; cd01838 474186000408 catalytic triad [active] 474186000409 oxyanion hole [active] 474186000410 active site 474186000411 Methyltransferase domain; Region: Methyltransf_31; pfam13847 474186000412 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 474186000413 S-adenosylmethionine binding site [chemical binding]; other site 474186000414 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 474186000415 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 474186000416 active site 474186000417 purine riboside binding site [chemical binding]; other site 474186000418 Transcriptional regulators [Transcription]; Region: PurR; COG1609 474186000419 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 474186000420 DNA binding site [nucleotide binding] 474186000421 domain linker motif; other site 474186000422 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 474186000423 dimerization interface [polypeptide binding]; other site 474186000424 ligand binding site [chemical binding]; other site 474186000425 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 474186000426 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 474186000427 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 474186000428 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 474186000429 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 474186000430 intersubunit interface [polypeptide binding]; other site 474186000431 active site 474186000432 catalytic residue [active] 474186000433 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 474186000434 active site 474186000435 catalytic motif [active] 474186000436 Zn binding site [ion binding]; other site 474186000437 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 474186000438 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 474186000439 ligand binding site [chemical binding]; other site 474186000440 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 474186000441 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 474186000442 ligand binding site [chemical binding]; other site 474186000443 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 474186000444 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 474186000445 Walker A/P-loop; other site 474186000446 ATP binding site [chemical binding]; other site 474186000447 Q-loop/lid; other site 474186000448 ABC transporter signature motif; other site 474186000449 Walker B; other site 474186000450 D-loop; other site 474186000451 H-loop/switch region; other site 474186000452 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 474186000453 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 474186000454 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 474186000455 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 474186000456 TM-ABC transporter signature motif; other site 474186000457 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 474186000458 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 474186000459 TM-ABC transporter signature motif; other site 474186000460 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 474186000461 nucleophilic elbow; other site 474186000462 catalytic triad; other site 474186000463 phosphopentomutase; Provisional; Region: PRK05362 474186000464 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 474186000465 purine nucleoside phosphorylase; Provisional; Region: PRK08202 474186000466 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 474186000467 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 474186000468 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 474186000469 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 474186000470 putative ligand binding residues [chemical binding]; other site 474186000471 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 474186000472 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 474186000473 Walker A/P-loop; other site 474186000474 ATP binding site [chemical binding]; other site 474186000475 Q-loop/lid; other site 474186000476 ABC transporter signature motif; other site 474186000477 Walker B; other site 474186000478 D-loop; other site 474186000479 H-loop/switch region; other site 474186000480 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 474186000481 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 474186000482 ABC-ATPase subunit interface; other site 474186000483 dimer interface [polypeptide binding]; other site 474186000484 putative PBP binding regions; other site 474186000485 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 474186000486 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 474186000487 ABC-ATPase subunit interface; other site 474186000488 dimer interface [polypeptide binding]; other site 474186000489 putative PBP binding regions; other site 474186000490 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 474186000491 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 474186000492 dimer interface [polypeptide binding]; other site 474186000493 active site 474186000494 metal binding site [ion binding]; metal-binding site 474186000495 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 474186000496 catalytic core [active] 474186000497 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 474186000498 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 474186000499 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 474186000500 catalytic residues [active] 474186000501 catalytic nucleophile [active] 474186000502 Presynaptic Site I dimer interface [polypeptide binding]; other site 474186000503 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 474186000504 Synaptic Flat tetramer interface [polypeptide binding]; other site 474186000505 Synaptic Site I dimer interface [polypeptide binding]; other site 474186000506 DNA binding site [nucleotide binding] 474186000507 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 474186000508 tetramer (dimer of dimers) interface [polypeptide binding]; other site 474186000509 active site 474186000510 dimer interface [polypeptide binding]; other site 474186000511 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 474186000512 S17 interaction site [polypeptide binding]; other site 474186000513 S8 interaction site; other site 474186000514 16S rRNA interaction site [nucleotide binding]; other site 474186000515 streptomycin interaction site [chemical binding]; other site 474186000516 23S rRNA interaction site [nucleotide binding]; other site 474186000517 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 474186000518 30S ribosomal protein S7; Validated; Region: PRK05302 474186000519 elongation factor G; Reviewed; Region: PRK00007 474186000520 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 474186000521 G1 box; other site 474186000522 putative GEF interaction site [polypeptide binding]; other site 474186000523 GTP/Mg2+ binding site [chemical binding]; other site 474186000524 Switch I region; other site 474186000525 G2 box; other site 474186000526 G3 box; other site 474186000527 Switch II region; other site 474186000528 G4 box; other site 474186000529 G5 box; other site 474186000530 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 474186000531 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 474186000532 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 474186000533 elongation factor Tu; Reviewed; Region: PRK00049 474186000534 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 474186000535 G1 box; other site 474186000536 GEF interaction site [polypeptide binding]; other site 474186000537 GTP/Mg2+ binding site [chemical binding]; other site 474186000538 Switch I region; other site 474186000539 G2 box; other site 474186000540 G3 box; other site 474186000541 Switch II region; other site 474186000542 G4 box; other site 474186000543 G5 box; other site 474186000544 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 474186000545 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 474186000546 Antibiotic Binding Site [chemical binding]; other site 474186000547 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 474186000548 dimer interface [polypeptide binding]; other site 474186000549 substrate binding site [chemical binding]; other site 474186000550 ATP binding site [chemical binding]; other site 474186000551 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 474186000552 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 474186000553 S-adenosylmethionine binding site [chemical binding]; other site 474186000554 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 474186000555 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 474186000556 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 474186000557 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 474186000558 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 474186000559 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 474186000560 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 474186000561 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 474186000562 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 474186000563 putative translocon binding site; other site 474186000564 protein-rRNA interface [nucleotide binding]; other site 474186000565 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 474186000566 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 474186000567 G-X-X-G motif; other site 474186000568 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 474186000569 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 474186000570 23S rRNA interface [nucleotide binding]; other site 474186000571 5S rRNA interface [nucleotide binding]; other site 474186000572 putative antibiotic binding site [chemical binding]; other site 474186000573 L25 interface [polypeptide binding]; other site 474186000574 L27 interface [polypeptide binding]; other site 474186000575 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 474186000576 23S rRNA interface [nucleotide binding]; other site 474186000577 putative translocon interaction site; other site 474186000578 signal recognition particle (SRP54) interaction site; other site 474186000579 L23 interface [polypeptide binding]; other site 474186000580 trigger factor interaction site; other site 474186000581 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 474186000582 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 474186000583 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 474186000584 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 474186000585 RNA binding site [nucleotide binding]; other site 474186000586 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 474186000587 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 474186000588 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 474186000589 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 474186000590 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 474186000591 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 474186000592 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 474186000593 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 474186000594 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 474186000595 5S rRNA interface [nucleotide binding]; other site 474186000596 L27 interface [polypeptide binding]; other site 474186000597 23S rRNA interface [nucleotide binding]; other site 474186000598 L5 interface [polypeptide binding]; other site 474186000599 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 474186000600 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 474186000601 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 474186000602 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 474186000603 23S rRNA binding site [nucleotide binding]; other site 474186000604 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 474186000605 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 474186000606 SecY translocase; Region: SecY; pfam00344 474186000607 adenylate kinase; Reviewed; Region: adk; PRK00279 474186000608 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 474186000609 AMP-binding site [chemical binding]; other site 474186000610 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 474186000611 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 474186000612 rRNA binding site [nucleotide binding]; other site 474186000613 predicted 30S ribosome binding site; other site 474186000614 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 474186000615 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 474186000616 30S ribosomal protein S13; Region: bact_S13; TIGR03631 474186000617 30S ribosomal protein S11; Validated; Region: PRK05309 474186000618 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 474186000619 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 474186000620 alphaNTD homodimer interface [polypeptide binding]; other site 474186000621 alphaNTD - beta interaction site [polypeptide binding]; other site 474186000622 alphaNTD - beta' interaction site [polypeptide binding]; other site 474186000623 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 474186000624 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 474186000625 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 474186000626 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_subfamily5; cd08019 474186000627 metal binding site [ion binding]; metal-binding site 474186000628 putative dimer interface [polypeptide binding]; other site 474186000629 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635 474186000630 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 474186000631 Walker A/P-loop; other site 474186000632 ATP binding site [chemical binding]; other site 474186000633 Q-loop/lid; other site 474186000634 ABC transporter signature motif; other site 474186000635 Walker B; other site 474186000636 D-loop; other site 474186000637 H-loop/switch region; other site 474186000638 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13634 474186000639 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 474186000640 Walker A/P-loop; other site 474186000641 ATP binding site [chemical binding]; other site 474186000642 Q-loop/lid; other site 474186000643 ABC transporter signature motif; other site 474186000644 Walker B; other site 474186000645 D-loop; other site 474186000646 H-loop/switch region; other site 474186000647 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 474186000648 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 474186000649 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 474186000650 dimerization interface 3.5A [polypeptide binding]; other site 474186000651 active site 474186000652 hypothetical protein; Provisional; Region: PRK00967 474186000653 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 474186000654 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 474186000655 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 474186000656 Coenzyme A binding pocket [chemical binding]; other site 474186000657 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 474186000658 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 474186000659 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 474186000660 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 474186000661 Walker A/P-loop; other site 474186000662 ATP binding site [chemical binding]; other site 474186000663 Q-loop/lid; other site 474186000664 ABC transporter signature motif; other site 474186000665 Walker B; other site 474186000666 D-loop; other site 474186000667 H-loop/switch region; other site 474186000668 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 474186000669 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 474186000670 substrate binding pocket [chemical binding]; other site 474186000671 membrane-bound complex binding site; other site 474186000672 hinge residues; other site 474186000673 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 474186000674 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 474186000675 dimer interface [polypeptide binding]; other site 474186000676 conserved gate region; other site 474186000677 putative PBP binding loops; other site 474186000678 ABC-ATPase subunit interface; other site 474186000679 NAD-dependent deacetylase; Provisional; Region: PRK00481 474186000680 SIR2H: Uncharacterized prokaryotic Sir2 homologs from several gram positive bacterial species and Fusobacteria; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone...; Region: SIR2H; cd01411 474186000681 NAD+ binding site [chemical binding]; other site 474186000682 substrate binding site [chemical binding]; other site 474186000683 putative Zn binding site [ion binding]; other site 474186000684 maltose O-acetyltransferase; Provisional; Region: PRK10092 474186000685 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 474186000686 active site 474186000687 substrate binding site [chemical binding]; other site 474186000688 trimer interface [polypeptide binding]; other site 474186000689 CoA binding site [chemical binding]; other site 474186000690 monofunctional chorismate mutase, gram positive-type, clade 2; Region: CM_mono_grmpos; TIGR01805 474186000691 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 474186000692 HTH domain; Region: HTH_11; pfam08279 474186000693 3H domain; Region: 3H; pfam02829 474186000694 E4 protein; Provisional; Region: PHA03420 474186000695 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 474186000696 CHAP domain; Region: CHAP; pfam05257 474186000697 Uncharacterized Staphylococcus aureus AldA1 (SACOL0154) aldehyde dehydrogenase-like; Region: ALDH_StaphAldA1; cd07117 474186000698 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 474186000699 NAD(P) binding site [chemical binding]; other site 474186000700 catalytic residues [active] 474186000701 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 474186000702 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 474186000703 tetramer (dimer of dimers) interface [polypeptide binding]; other site 474186000704 NAD binding site [chemical binding]; other site 474186000705 dimer interface [polypeptide binding]; other site 474186000706 substrate binding site [chemical binding]; other site 474186000707 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 474186000708 putative active site [active] 474186000709 catalytic residue [active] 474186000710 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 474186000711 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 474186000712 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 474186000713 ATP binding site [chemical binding]; other site 474186000714 putative Mg++ binding site [ion binding]; other site 474186000715 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 474186000716 nucleotide binding region [chemical binding]; other site 474186000717 ATP-binding site [chemical binding]; other site 474186000718 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 474186000719 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 474186000720 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 474186000721 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 474186000722 RNA binding surface [nucleotide binding]; other site 474186000723 hypothetical protein; Provisional; Region: PRK08582 474186000724 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 474186000725 RNA binding site [nucleotide binding]; other site 474186000726 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 474186000727 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 474186000728 Ligand Binding Site [chemical binding]; other site 474186000729 TilS substrate C-terminal domain; Region: TilS_C; smart00977 474186000730 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 474186000731 active site 474186000732 FtsH Extracellular; Region: FtsH_ext; pfam06480 474186000733 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 474186000734 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 474186000735 Walker A motif; other site 474186000736 ATP binding site [chemical binding]; other site 474186000737 Walker B motif; other site 474186000738 arginine finger; other site 474186000739 Peptidase family M41; Region: Peptidase_M41; pfam01434 474186000740 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 474186000741 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 474186000742 dimerization interface [polypeptide binding]; other site 474186000743 domain crossover interface; other site 474186000744 redox-dependent activation switch; other site 474186000745 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 474186000746 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 474186000747 FMN binding site [chemical binding]; other site 474186000748 active site 474186000749 catalytic residues [active] 474186000750 substrate binding site [chemical binding]; other site 474186000751 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 474186000752 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 474186000753 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 474186000754 dimer interface [polypeptide binding]; other site 474186000755 putative anticodon binding site; other site 474186000756 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 474186000757 motif 1; other site 474186000758 active site 474186000759 motif 2; other site 474186000760 motif 3; other site 474186000761 CAT RNA binding domain; Region: CAT_RBD; cl03904 474186000762 PRD domain; Region: PRD; pfam00874 474186000763 PRD domain; Region: PRD; pfam00874 474186000764 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 474186000765 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 474186000766 active site turn [active] 474186000767 phosphorylation site [posttranslational modification] 474186000768 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 474186000769 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 474186000770 HPr interaction site; other site 474186000771 glycerol kinase (GK) interaction site [polypeptide binding]; other site 474186000772 active site 474186000773 phosphorylation site [posttranslational modification] 474186000774 6-phospho-beta-glucosidase; Reviewed; Region: arb; PRK09593 474186000775 beta-galactosidase; Region: BGL; TIGR03356 474186000776 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 474186000777 beta-galactosidase; Region: BGL; TIGR03356 474186000778 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 474186000779 catalytic core [active] 474186000780 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 474186000781 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 474186000782 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 474186000783 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 474186000784 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 474186000785 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 474186000786 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 474186000787 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 474186000788 DNA binding site [nucleotide binding] 474186000789 active site 474186000790 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 474186000791 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 474186000792 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 474186000793 Zn2+ binding site [ion binding]; other site 474186000794 Mg2+ binding site [ion binding]; other site 474186000795 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 474186000796 Cation efflux family; Region: Cation_efflux; pfam01545 474186000797 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK06079 474186000798 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 474186000799 NAD binding site [chemical binding]; other site 474186000800 homotetramer interface [polypeptide binding]; other site 474186000801 homodimer interface [polypeptide binding]; other site 474186000802 substrate binding site [chemical binding]; other site 474186000803 active site 474186000804 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 474186000805 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 474186000806 dimer interface [polypeptide binding]; other site 474186000807 active site 474186000808 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 474186000809 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 474186000810 Dihydroorotate dehydrogenase (DHOD) class 1A FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1A_like; cd04741 474186000811 active site 474186000812 FMN binding site [chemical binding]; other site 474186000813 substrate binding site [chemical binding]; other site 474186000814 catalytic residues [active] 474186000815 homodimer interface [polypeptide binding]; other site 474186000816 Fibronectin-binding protein (FBP); Region: FBP; pfam07299 474186000817 elongation factor P; Validated; Region: PRK00529 474186000818 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 474186000819 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 474186000820 RNA binding site [nucleotide binding]; other site 474186000821 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 474186000822 RNA binding site [nucleotide binding]; other site 474186000823 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 474186000824 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 474186000825 dimer interface [polypeptide binding]; other site 474186000826 pyridoxal 5'-phosphate binding site [chemical binding]; other site 474186000827 catalytic residue [active] 474186000828 cystathionine gamma-synthase/cystathionine beta-lyase; Validated; Region: PRK06176 474186000829 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 474186000830 homodimer interface [polypeptide binding]; other site 474186000831 substrate-cofactor binding pocket; other site 474186000832 pyridoxal 5'-phosphate binding site [chemical binding]; other site 474186000833 catalytic residue [active] 474186000834 6-phospho-beta-glucosidase; Reviewed; Region: celA; PRK09589 474186000835 beta-galactosidase; Region: BGL; TIGR03356 474186000836 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 474186000837 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 474186000838 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 474186000839 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 474186000840 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 474186000841 putative active site [active] 474186000842 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 474186000843 RibD C-terminal domain; Region: RibD_C; cl17279 474186000844 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 474186000845 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 474186000846 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 474186000847 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 474186000848 copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698 474186000849 Penicillinase repressor; Region: Pencillinase_R; pfam03965 474186000850 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 474186000851 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 474186000852 metal-binding site [ion binding] 474186000853 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 474186000854 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 474186000855 metal-binding site [ion binding] 474186000856 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 474186000857 Soluble P-type ATPase [General function prediction only]; Region: COG4087 474186000858 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 474186000859 metal-binding site [ion binding] 474186000860 Predicted membrane protein [General function prediction only]; Region: COG4194 474186000861 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 474186000862 DNA-binding site [nucleotide binding]; DNA binding site 474186000863 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 474186000864 trimer interface [polypeptide binding]; other site 474186000865 active site 474186000866 G bulge; other site 474186000867 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 474186000868 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 474186000869 Zn binding site [ion binding]; other site 474186000870 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 474186000871 Zn binding site [ion binding]; other site 474186000872 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 474186000873 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 474186000874 GH18 domain of Chitinase D (ChiD). ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins. The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18; Region: GH18_chitinase_D-like; cd02871 474186000875 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 474186000876 putative active site [active] 474186000877 Chitin binding domain; Region: Chitin_bind_3; pfam03067 474186000878 Acyl-ACP thioesterase; Region: Acyl-ACP_TE; pfam01643 474186000879 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 474186000880 active site 474186000881 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 474186000882 active site 474186000883 Protein of unknown function DUF72; Region: DUF72; pfam01904 474186000884 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4696 474186000885 metal binding site [ion binding]; metal-binding site 474186000886 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 474186000887 aspartate kinase; Reviewed; Region: PRK09034 474186000888 putative catalytic residues [active] 474186000889 putative nucleotide binding site [chemical binding]; other site 474186000890 putative aspartate binding site [chemical binding]; other site 474186000891 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 474186000892 allosteric regulatory residue; other site 474186000893 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 474186000894 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 474186000895 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 474186000896 motif II; other site 474186000897 Septation ring formation regulator, EzrA; Region: EzrA; pfam06160 474186000898 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 474186000899 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 474186000900 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 474186000901 catalytic residue [active] 474186000902 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 474186000903 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 474186000904 active site 474186000905 phosphorylation site [posttranslational modification] 474186000906 intermolecular recognition site; other site 474186000907 dimerization interface [polypeptide binding]; other site 474186000908 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 474186000909 DNA binding site [nucleotide binding] 474186000910 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 474186000911 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 474186000912 dimer interface [polypeptide binding]; other site 474186000913 phosphorylation site [posttranslational modification] 474186000914 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 474186000915 ATP binding site [chemical binding]; other site 474186000916 Mg2+ binding site [ion binding]; other site 474186000917 G-X-G motif; other site 474186000918 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 474186000919 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 474186000920 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 474186000921 putative deaminase; Validated; Region: PRK06846 474186000922 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 474186000923 active site 474186000924 Fic/DOC family; Region: Fic; cl00960 474186000925 putative addiction module antidote; Region: doc_partner; TIGR02609 474186000926 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 474186000927 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 474186000928 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 474186000929 membrane protein FdrA; Validated; Region: PRK06091 474186000930 CoA binding domain; Region: CoA_binding; pfam02629 474186000931 CoA-ligase; Region: Ligase_CoA; pfam00549 474186000932 Protein of unknown function (DUF1116); Region: DUF1116; pfam06545 474186000933 Protein of unknown function (DUF2877); Region: DUF2877; pfam11392 474186000934 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 474186000935 D-galactonate transporter; Region: 2A0114; TIGR00893 474186000936 putative substrate translocation pore; other site 474186000937 carbamate kinase; Reviewed; Region: PRK12686 474186000938 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 474186000939 putative substrate binding site [chemical binding]; other site 474186000940 nucleotide binding site [chemical binding]; other site 474186000941 nucleotide binding site [chemical binding]; other site 474186000942 homodimer interface [polypeptide binding]; other site 474186000943 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 474186000944 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 474186000945 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 474186000946 cytosine deaminase; Provisional; Region: PRK05985 474186000947 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 474186000948 active site 474186000949 WxL domain surface cell wall-binding; Region: WxL; pfam13731 474186000950 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 474186000951 TATA element modulatory factor 1 DNA binding; Region: TMF_DNA_bd; pfam12329 474186000952 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 474186000953 T-box leader; OG1RF_nc10003 474186000954 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 474186000955 substrate binding site [chemical binding]; other site 474186000956 THF binding site; other site 474186000957 zinc-binding site [ion binding]; other site 474186000958 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 474186000959 Domain of unknown function DUF20; Region: UPF0118; pfam01594 474186000960 Short repeat of unknown function (DUF308); Region: DUF308; cl15828 474186000961 Protein of unknown function (DUF969); Region: DUF969; pfam06149 474186000962 Predicted membrane protein [Function unknown]; Region: COG3817 474186000963 Protein of unknown function (DUF979); Region: DUF979; pfam06166 474186000964 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 474186000965 putative substrate binding pocket [chemical binding]; other site 474186000966 AC domain interface; other site 474186000967 catalytic triad [active] 474186000968 AB domain interface; other site 474186000969 interchain disulfide; other site 474186000970 T-box leader; OG1RF_nc10004 474186000971 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 474186000972 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 474186000973 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 474186000974 putative DNA binding site [nucleotide binding]; other site 474186000975 putative Zn2+ binding site [ion binding]; other site 474186000976 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 474186000977 dimer interface [polypeptide binding]; other site 474186000978 FMN binding site [chemical binding]; other site 474186000979 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 474186000980 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 474186000981 active site 474186000982 motif I; other site 474186000983 motif II; other site 474186000984 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 474186000985 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 474186000986 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 474186000987 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 474186000988 active site 474186000989 P-loop; other site 474186000990 phosphorylation site [posttranslational modification] 474186000991 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 474186000992 active site 474186000993 P-loop; other site 474186000994 phosphorylation site [posttranslational modification] 474186000995 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 474186000996 PRD domain; Region: PRD; pfam00874 474186000997 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 474186000998 P-loop; other site 474186000999 active site 474186001000 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 474186001001 active site 474186001002 phosphorylation site [posttranslational modification] 474186001003 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 474186001004 active site 474186001005 phosphorylation site [posttranslational modification] 474186001006 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 474186001007 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 474186001008 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 474186001009 active site 474186001010 P-loop; other site 474186001011 phosphorylation site [posttranslational modification] 474186001012 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 474186001013 active site 474186001014 P-loop; other site 474186001015 phosphorylation site [posttranslational modification] 474186001016 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 474186001017 active site 474186001018 phosphorylation site [posttranslational modification] 474186001019 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 474186001020 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 474186001021 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 474186001022 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 474186001023 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 474186001024 NADH(P)-binding; Region: NAD_binding_10; pfam13460 474186001025 NAD(P) binding site [chemical binding]; other site 474186001026 active site 474186001027 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 474186001028 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 474186001029 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 474186001030 Walker A/P-loop; other site 474186001031 ATP binding site [chemical binding]; other site 474186001032 Q-loop/lid; other site 474186001033 ABC transporter signature motif; other site 474186001034 Walker B; other site 474186001035 D-loop; other site 474186001036 H-loop/switch region; other site 474186001037 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 474186001038 FtsX-like permease family; Region: FtsX; pfam02687 474186001039 TrbC/VIRB2 family; Region: TrbC; pfam04956 474186001040 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 474186001041 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 474186001042 putative substrate translocation pore; other site 474186001043 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 474186001044 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 474186001045 DNA binding residues [nucleotide binding] 474186001046 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 474186001047 putative dimer interface [polypeptide binding]; other site 474186001048 Transcriptional regulator [Transcription]; Region: IclR; COG1414 474186001049 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 474186001050 Bacterial transcriptional regulator; Region: IclR; pfam01614 474186001051 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 474186001052 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 474186001053 active site 474186001054 intersubunit interface [polypeptide binding]; other site 474186001055 catalytic residue [active] 474186001056 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 474186001057 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 474186001058 substrate binding site [chemical binding]; other site 474186001059 ATP binding site [chemical binding]; other site 474186001060 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 474186001061 gluconate 5-dehydrogenase; Provisional; Region: PRK07097 474186001062 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 474186001063 NADP binding site [chemical binding]; other site 474186001064 homodimer interface [polypeptide binding]; other site 474186001065 active site 474186001066 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 474186001067 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 474186001068 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 474186001069 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 474186001070 DctM-like transporters; Region: DctM; pfam06808 474186001071 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 474186001072 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 474186001073 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 474186001074 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 474186001075 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 474186001076 N- and C-terminal domain interface [polypeptide binding]; other site 474186001077 rhamnulokinase; Region: rhamnulo_kin; TIGR02627 474186001078 active site 474186001079 putative catalytic site [active] 474186001080 metal binding site [ion binding]; metal-binding site 474186001081 ATP binding site [chemical binding]; other site 474186001082 carbohydrate binding site [chemical binding]; other site 474186001083 L-rhamnose isomerase; Provisional; Region: PRK01076 474186001084 rhamnulose-1-phosphate aldolase; Region: rhamnu_1P_ald; TIGR02624 474186001085 intersubunit interface [polypeptide binding]; other site 474186001086 active site 474186001087 Zn2+ binding site [ion binding]; other site 474186001088 Domain of unknown function (DUF718); Region: DUF718; cl01281 474186001089 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 474186001090 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 474186001091 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 474186001092 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 474186001093 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 474186001094 Metal-binding active site; metal-binding site 474186001095 amino acid/peptide transporter (Peptide:H+ symporter), bacterial; Region: yjdL_sub1_fam; TIGR00924 474186001096 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 474186001097 putative substrate translocation pore; other site 474186001098 POT family; Region: PTR2; pfam00854 474186001099 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 474186001100 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 474186001101 CoenzymeA binding site [chemical binding]; other site 474186001102 subunit interaction site [polypeptide binding]; other site 474186001103 PHB binding site; other site 474186001104 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 474186001105 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 474186001106 substrate binding site [chemical binding]; other site 474186001107 oxyanion hole (OAH) forming residues; other site 474186001108 trimer interface [polypeptide binding]; other site 474186001109 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK03640 474186001110 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 474186001111 acyl-activating enzyme (AAE) consensus motif; other site 474186001112 putative AMP binding site [chemical binding]; other site 474186001113 putative active site [active] 474186001114 putative CoA binding site [chemical binding]; other site 474186001115 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 474186001116 isochorismate synthases; Region: isochor_syn; TIGR00543 474186001117 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 474186001118 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 474186001119 dimer interface [polypeptide binding]; other site 474186001120 tetramer interface [polypeptide binding]; other site 474186001121 PYR/PP interface [polypeptide binding]; other site 474186001122 TPP binding site [chemical binding]; other site 474186001123 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 474186001124 TPP-binding site; other site 474186001125 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 474186001126 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 474186001127 N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317 474186001128 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 474186001129 active site 474186001130 octamer interface [polypeptide binding]; other site 474186001131 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 474186001132 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 474186001133 active site 474186001134 trimer interface [polypeptide binding]; other site 474186001135 allosteric site; other site 474186001136 hexamer (dimer of trimers) interface [polypeptide binding]; other site 474186001137 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 474186001138 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 474186001139 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 474186001140 acyl-activating enzyme (AAE) consensus motif; other site 474186001141 acyl-activating enzyme (AAE) consensus motif; other site 474186001142 AMP binding site [chemical binding]; other site 474186001143 active site 474186001144 CoA binding site [chemical binding]; other site 474186001145 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 474186001146 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 474186001147 PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609 474186001148 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 474186001149 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 474186001150 active site 474186001151 phosphorylation site [posttranslational modification] 474186001152 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11557 474186001153 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 474186001154 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 474186001155 putative active site [active] 474186001156 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: PRK12570 474186001157 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 474186001158 putative active site [active] 474186001159 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 474186001160 Beta-lactamase; Region: Beta-lactamase; pfam00144 474186001161 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 474186001162 active pocket/dimerization site; other site 474186001163 active site 474186001164 phosphorylation site [posttranslational modification] 474186001165 Protein of unknown function (DUF1189); Region: DUF1189; pfam06691 474186001166 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 474186001167 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 474186001168 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 474186001169 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 474186001170 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 474186001171 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 474186001172 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 474186001173 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 474186001174 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 474186001175 active site 474186001176 trimer interface [polypeptide binding]; other site 474186001177 allosteric site; other site 474186001178 active site lid [active] 474186001179 hexamer (dimer of trimers) interface [polypeptide binding]; other site 474186001180 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 474186001181 MgtC family; Region: MgtC; pfam02308 474186001182 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 474186001183 Repair protein; Region: Repair_PSII; pfam04536 474186001184 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 474186001185 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 474186001186 dimer interface [polypeptide binding]; other site 474186001187 putative radical transfer pathway; other site 474186001188 diiron center [ion binding]; other site 474186001189 tyrosyl radical; other site 474186001190 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07306 474186001191 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 474186001192 Class I ribonucleotide reductase; Region: RNR_I; cd01679 474186001193 active site 474186001194 dimer interface [polypeptide binding]; other site 474186001195 catalytic residues [active] 474186001196 effector binding site; other site 474186001197 R2 peptide binding site; other site 474186001198 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 474186001199 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 474186001200 catalytic residues [active] 474186001201 Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918 474186001202 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 474186001203 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 474186001204 G1 box; other site 474186001205 GTP/Mg2+ binding site [chemical binding]; other site 474186001206 Switch I region; other site 474186001207 G2 box; other site 474186001208 G3 box; other site 474186001209 Switch II region; other site 474186001210 G4 box; other site 474186001211 G5 box; other site 474186001212 Nucleoside recognition; Region: Gate; pfam07670 474186001213 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 474186001214 Nucleoside recognition; Region: Gate; pfam07670 474186001215 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 474186001216 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 474186001217 active site 474186001218 catalytic tetrad [active] 474186001219 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 474186001220 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 474186001221 active site 474186001222 metal binding site [ion binding]; metal-binding site 474186001223 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 474186001224 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 474186001225 putative active site [active] 474186001226 catalytic site [active] 474186001227 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 474186001228 putative active site [active] 474186001229 catalytic site [active] 474186001230 T-box leader; OG1RF_nc10005 474186001231 tyrosyl-tRNA synthetase; Provisional; Region: PRK13354 474186001232 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 474186001233 active site 474186001234 HIGH motif; other site 474186001235 dimer interface [polypeptide binding]; other site 474186001236 KMSKS motif; other site 474186001237 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 474186001238 RNA binding surface [nucleotide binding]; other site 474186001239 tyrosine decarboxylase, Enterococcus type; Region: tyr_de_CO2_Ent; TIGR03811 474186001240 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 474186001241 catalytic residue [active] 474186001242 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 474186001243 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 474186001244 Protein of unknown function (DUF1307); Region: DUF1307; pfam06998 474186001245 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 474186001246 tetramer interfaces [polypeptide binding]; other site 474186001247 binuclear metal-binding site [ion binding]; other site 474186001248 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 474186001249 tetramer (dimer of dimers) interface [polypeptide binding]; other site 474186001250 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 474186001251 NAD binding site [chemical binding]; other site 474186001252 dimer interface [polypeptide binding]; other site 474186001253 substrate binding site [chemical binding]; other site 474186001254 Transcriptional regulator [Transcription]; Region: LysR; COG0583 474186001255 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 474186001256 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 474186001257 dimerization interface [polypeptide binding]; other site 474186001258 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 474186001259 C4-dicarboxylate transporters of the Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_C4-dicarb_trans; cd09325 474186001260 gating phenylalanine in ion channel; other site 474186001261 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 474186001262 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 474186001263 NAD(P) binding site [chemical binding]; other site 474186001264 active site 474186001265 Predicted transcriptional regulators [Transcription]; Region: COG1733 474186001266 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 474186001267 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 474186001268 dimer interface [polypeptide binding]; other site 474186001269 FMN binding site [chemical binding]; other site 474186001270 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 474186001271 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 474186001272 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 474186001273 Peptidase family M48; Region: Peptidase_M48; cl12018 474186001274 Transcriptional regulators [Transcription]; Region: PurR; COG1609 474186001275 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 474186001276 DNA binding site [nucleotide binding] 474186001277 domain linker motif; other site 474186001278 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 474186001279 putative dimerization interface [polypeptide binding]; other site 474186001280 putative ligand binding site [chemical binding]; other site 474186001281 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 474186001282 dimer interface [polypeptide binding]; other site 474186001283 FMN binding site [chemical binding]; other site 474186001284 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 474186001285 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 474186001286 putative metal binding site [ion binding]; other site 474186001287 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 474186001288 active site 474186001289 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 474186001290 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 474186001291 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 474186001292 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 474186001293 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 474186001294 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 474186001295 active site 474186001296 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 474186001297 active site 474186001298 Fe-S cluster binding site [ion binding]; other site 474186001299 multidrug efflux pump VmrA; Reviewed; Region: vmrA; PRK09575 474186001300 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 474186001301 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 474186001302 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_2; cd09607 474186001303 active site 474186001304 Zn binding site [ion binding]; other site 474186001305 Predicted integral membrane protein [Function unknown]; Region: COG5652 474186001306 hypothetical protein; Validated; Region: PRK00110 474186001307 C_GCAxxG_C_C family probable redox protein; Region: C_GCAxxG_C_C; TIGR01909 474186001308 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 474186001309 Zn binding site [ion binding]; other site 474186001310 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 474186001311 Zn binding site [ion binding]; other site 474186001312 putative hydrolase; Provisional; Region: PRK11460 474186001313 Predicted esterase [General function prediction only]; Region: COG0400 474186001314 UDP-N-acetylmuramoylalanyl-D-glutamate--L-lysine ligase; Provisional; Region: PRK14022 474186001315 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 474186001316 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 474186001317 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 474186001318 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 474186001319 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 474186001320 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 474186001321 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 474186001322 RNA binding surface [nucleotide binding]; other site 474186001323 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 474186001324 active site 474186001325 uracil binding [chemical binding]; other site 474186001326 dipeptidase PepV; Region: dipeptidase; TIGR01886 474186001327 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 474186001328 active site 474186001329 metal binding site [ion binding]; metal-binding site 474186001330 DNA primase large subunit; Validated; Region: PRK03968 474186001331 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 474186001332 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 474186001333 CRISPR/Cas system-associated protein Cas1; Region: Cas1_II; cd09720 474186001334 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09638 474186001335 CRISPR/Cas system-associated protein Csn2; Region: Csn2; cd09758 474186001336 CRISPR type II-A/NMEMI-associated protein Csn2; Region: cas_Csn2; TIGR01866 474186001337 tetramer interface [polypeptide binding]; other site 474186001338 putative DNA binding site [nucleotide binding]; other site 474186001339 Ca binding site [ion binding]; other site 474186001340 Ca binding site [ion binding]; other site 474186001341 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 474186001342 Acyltransferase family; Region: Acyl_transf_3; pfam01757 474186001343 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 474186001344 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 474186001345 Walker A/P-loop; other site 474186001346 ATP binding site [chemical binding]; other site 474186001347 Q-loop/lid; other site 474186001348 ABC transporter signature motif; other site 474186001349 Walker B; other site 474186001350 D-loop; other site 474186001351 H-loop/switch region; other site 474186001352 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 474186001353 ABC-ATPase subunit interface; other site 474186001354 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 474186001355 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 474186001356 Arginine repressor [Transcription]; Region: ArgR; COG1438 474186001357 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 474186001358 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 474186001359 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 474186001360 active site 474186001361 substrate binding site [chemical binding]; other site 474186001362 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 474186001363 metal binding site [ion binding]; metal-binding site 474186001364 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 474186001365 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 474186001366 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 474186001367 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 474186001368 active site 474186001369 Transglycosylase; Region: Transgly; pfam00912 474186001370 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 474186001371 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 474186001372 hypothetical protein; Provisional; Region: PRK13676 474186001373 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 474186001374 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 474186001375 active site 474186001376 metal binding site [ion binding]; metal-binding site 474186001377 DNA binding site [nucleotide binding] 474186001378 Uncharacterized conserved protein [Function unknown]; Region: COG4717 474186001379 Uncharacterized conserved protein [Function unknown]; Region: COG4717 474186001380 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 474186001381 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 474186001382 generic binding surface II; other site 474186001383 generic binding surface I; other site 474186001384 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 474186001385 Zn2+ binding site [ion binding]; other site 474186001386 Mg2+ binding site [ion binding]; other site 474186001387 foldase protein PrsA; Reviewed; Region: prsA; PRK01326 474186001388 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 474186001389 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 474186001390 HIT family signature motif; other site 474186001391 catalytic residue [active] 474186001392 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 474186001393 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 474186001394 Walker A/P-loop; other site 474186001395 ATP binding site [chemical binding]; other site 474186001396 Q-loop/lid; other site 474186001397 ABC transporter signature motif; other site 474186001398 Walker B; other site 474186001399 D-loop; other site 474186001400 H-loop/switch region; other site 474186001401 Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975 474186001402 Thiamine kinase and related kinases [Coenzyme transport and metabolism]; Region: ycfN; COG0510 474186001403 Phosphotransferase enzyme family; Region: APH; pfam01636 474186001404 active site 474186001405 substrate binding site [chemical binding]; other site 474186001406 ATP binding site [chemical binding]; other site 474186001407 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 474186001408 S-adenosylmethionine binding site [chemical binding]; other site 474186001409 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 474186001410 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 474186001411 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 474186001412 putative active site [active] 474186001413 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 474186001414 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 474186001415 putative substrate binding site [chemical binding]; other site 474186001416 putative ATP binding site [chemical binding]; other site 474186001417 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 474186001418 active site 474186001419 P-loop; other site 474186001420 phosphorylation site [posttranslational modification] 474186001421 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 474186001422 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 474186001423 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 474186001424 active site 474186001425 phosphorylation site [posttranslational modification] 474186001426 Class I aldolases; Region: Aldolase_Class_I; cl17187 474186001427 hypothetical protein; Provisional; Region: PRK13662 474186001428 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 474186001429 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 474186001430 Coenzyme A binding pocket [chemical binding]; other site 474186001431 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 474186001432 Domain of unknown function DUF20; Region: UPF0118; pfam01594 474186001433 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 474186001434 Domain of unknown function DUF21; Region: DUF21; pfam01595 474186001435 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 474186001436 Transporter associated domain; Region: CorC_HlyC; pfam03471 474186001437 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 474186001438 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 474186001439 G1 box; other site 474186001440 putative GEF interaction site [polypeptide binding]; other site 474186001441 GTP/Mg2+ binding site [chemical binding]; other site 474186001442 Switch I region; other site 474186001443 G2 box; other site 474186001444 G3 box; other site 474186001445 Switch II region; other site 474186001446 G4 box; other site 474186001447 G5 box; other site 474186001448 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 474186001449 Protein of unknown function (DUF3290); Region: DUF3290; pfam11694 474186001450 Predicted membrane protein [Function unknown]; Region: COG2323 474186001451 Domain of unknown function (DUF1827); Region: DUF1827; pfam08860 474186001452 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 474186001453 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 474186001454 Walker A motif; other site 474186001455 ATP binding site [chemical binding]; other site 474186001456 Walker B motif; other site 474186001457 arginine finger; other site 474186001458 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 474186001459 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 474186001460 Walker A motif; other site 474186001461 ATP binding site [chemical binding]; other site 474186001462 Walker B motif; other site 474186001463 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 474186001464 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 474186001465 dimerization domain swap beta strand [polypeptide binding]; other site 474186001466 regulatory protein interface [polypeptide binding]; other site 474186001467 active site 474186001468 regulatory phosphorylation site [posttranslational modification]; other site 474186001469 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 474186001470 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 474186001471 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 474186001472 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 474186001473 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 474186001474 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 474186001475 WxL domain surface cell wall-binding; Region: WxL; pfam13731 474186001476 trigger factor; Provisional; Region: tig; PRK01490 474186001477 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 474186001478 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 474186001479 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 474186001480 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 474186001481 active site 474186001482 phosphorylation site [posttranslational modification] 474186001483 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 474186001484 active site 474186001485 P-loop; other site 474186001486 phosphorylation site [posttranslational modification] 474186001487 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 474186001488 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 474186001489 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 474186001490 putative substrate binding site [chemical binding]; other site 474186001491 putative ATP binding site [chemical binding]; other site 474186001492 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 474186001493 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 474186001494 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 474186001495 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 474186001496 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 474186001497 Cl- selectivity filter; other site 474186001498 Cl- binding residues [ion binding]; other site 474186001499 pore gating glutamate residue; other site 474186001500 dimer interface [polypeptide binding]; other site 474186001501 H+/Cl- coupling transport residue; other site 474186001502 TrkA-C domain; Region: TrkA_C; pfam02080 474186001503 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 474186001504 Part of AAA domain; Region: AAA_19; pfam13245 474186001505 Family description; Region: UvrD_C_2; pfam13538 474186001506 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 474186001507 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 474186001508 nucleotide binding pocket [chemical binding]; other site 474186001509 K-X-D-G motif; other site 474186001510 catalytic site [active] 474186001511 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 474186001512 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 474186001513 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 474186001514 Dimer interface [polypeptide binding]; other site 474186001515 BRCT sequence motif; other site 474186001516 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 474186001517 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 474186001518 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 474186001519 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 474186001520 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 474186001521 GatB domain; Region: GatB_Yqey; smart00845 474186001522 putative lipid kinase; Reviewed; Region: PRK13055 474186001523 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 474186001524 TRAM domain; Region: TRAM; pfam01938 474186001525 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 474186001526 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 474186001527 S-adenosylmethionine binding site [chemical binding]; other site 474186001528 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 474186001529 catalytic residues [active] 474186001530 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 474186001531 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 474186001532 DNA binding residues [nucleotide binding] 474186001533 dimerization interface [polypeptide binding]; other site 474186001534 putrescine carbamoyltransferase; Provisional; Region: PRK02255 474186001535 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 474186001536 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 474186001537 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 474186001538 agmatine deiminase; Provisional; Region: PRK13551 474186001539 agmatine deiminase; Region: agmatine_aguA; TIGR03380 474186001540 carbamate kinase; Reviewed; Region: PRK12686 474186001541 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 474186001542 putative substrate binding site [chemical binding]; other site 474186001543 nucleotide binding site [chemical binding]; other site 474186001544 nucleotide binding site [chemical binding]; other site 474186001545 homodimer interface [polypeptide binding]; other site 474186001546 amidase; Provisional; Region: PRK06707 474186001547 Amidase; Region: Amidase; cl11426 474186001548 nicotinamide mononucleotide transporter PnuC; Region: NMN_trans_PnuC; TIGR01528 474186001549 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 474186001550 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 474186001551 Substrate-binding site [chemical binding]; other site 474186001552 Substrate specificity [chemical binding]; other site 474186001553 Protein of unknown function (DUF1149); Region: DUF1149; pfam06619 474186001554 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 474186001555 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 474186001556 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 474186001557 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 474186001558 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 474186001559 Beta-lactamase; Region: Beta-lactamase; pfam00144 474186001560 Predicted membrane protein [Function unknown]; Region: COG4420 474186001561 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 474186001562 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 474186001563 active site residue [active] 474186001564 Protein of unknown function (DUF3650); Region: DUF3650; pfam12368 474186001565 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 474186001566 WxL domain surface cell wall-binding; Region: WxL; pfam13731 474186001567 WxL domain surface cell wall-binding; Region: WxL; pfam13731 474186001568 legume lectins; Region: lectin_L-type; cd01951 474186001569 homotetramer interaction site [polypeptide binding]; other site 474186001570 homodimer interaction site [polypeptide binding]; other site 474186001571 carbohydrate binding site [chemical binding]; other site 474186001572 metal binding site [ion binding]; metal-binding site 474186001573 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 474186001574 WxL domain surface cell wall-binding; Region: WxL; pfam13731 474186001575 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 474186001576 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 474186001577 Mga helix-turn-helix domain; Region: Mga; pfam05043 474186001578 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 474186001579 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 474186001580 Soluble P-type ATPase [General function prediction only]; Region: COG4087 474186001581 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 474186001582 MgtC family; Region: MgtC; pfam02308 474186001583 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 474186001584 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 474186001585 Walker A/P-loop; other site 474186001586 ATP binding site [chemical binding]; other site 474186001587 Q-loop/lid; other site 474186001588 ABC transporter signature motif; other site 474186001589 Walker B; other site 474186001590 D-loop; other site 474186001591 H-loop/switch region; other site 474186001592 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 474186001593 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 474186001594 substrate binding pocket [chemical binding]; other site 474186001595 membrane-bound complex binding site; other site 474186001596 hinge residues; other site 474186001597 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 474186001598 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 474186001599 substrate binding pocket [chemical binding]; other site 474186001600 membrane-bound complex binding site; other site 474186001601 hinge residues; other site 474186001602 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 474186001603 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 474186001604 dimer interface [polypeptide binding]; other site 474186001605 conserved gate region; other site 474186001606 putative PBP binding loops; other site 474186001607 ABC-ATPase subunit interface; other site 474186001608 excinuclease ABC subunit B; Provisional; Region: PRK05298 474186001609 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 474186001610 ATP binding site [chemical binding]; other site 474186001611 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 474186001612 nucleotide binding region [chemical binding]; other site 474186001613 ATP-binding site [chemical binding]; other site 474186001614 Ultra-violet resistance protein B; Region: UvrB; pfam12344 474186001615 UvrB/uvrC motif; Region: UVR; pfam02151 474186001616 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 474186001617 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 474186001618 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 474186001619 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 474186001620 YusW-like protein; Region: YusW; pfam14039 474186001621 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 474186001622 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 474186001623 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 474186001624 phosphate binding site [ion binding]; other site 474186001625 putative substrate binding pocket [chemical binding]; other site 474186001626 dimer interface [polypeptide binding]; other site 474186001627 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 474186001628 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 474186001629 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 474186001630 Thioredoxin; Region: Thioredoxin_4; pfam13462 474186001631 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 474186001632 Clp protease; Region: CLP_protease; pfam00574 474186001633 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 474186001634 oligomer interface [polypeptide binding]; other site 474186001635 active site residues [active] 474186001636 Protein of unknown function (DUF1622); Region: DUF1622; pfam07784 474186001637 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 474186001638 metal ion-dependent adhesion site (MIDAS); other site 474186001639 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 474186001640 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 474186001641 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 474186001642 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 474186001643 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 474186001644 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 474186001645 Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; pfam10110 474186001646 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 474186001647 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579 474186001648 putative active site [active] 474186001649 catalytic site [active] 474186001650 putative metal binding site [ion binding]; other site 474186001651 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 474186001652 nudix motif; other site 474186001653 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 474186001654 DNA-binding site [nucleotide binding]; DNA binding site 474186001655 RNA-binding motif; other site 474186001656 RNA polymerase sigma-54 factor; Region: rpoN_sigma; TIGR02395 474186001657 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 474186001658 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 474186001659 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 474186001660 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 474186001661 catalytic triad [active] 474186001662 catalytic triad [active] 474186001663 oxyanion hole [active] 474186001664 S-adenosylmethionine synthetase; Validated; Region: PRK05250 474186001665 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 474186001666 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 474186001667 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 474186001668 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 474186001669 Major Facilitator Superfamily; Region: MFS_1; pfam07690 474186001670 putative substrate translocation pore; other site 474186001671 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 474186001672 Predicted esterase [General function prediction only]; Region: COG0627 474186001673 S-formylglutathione hydrolase; Region: PLN02442 474186001674 tetracycline repressor protein TetR; Provisional; Region: PRK13756 474186001675 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 474186001676 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 474186001677 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 474186001678 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 474186001679 Walker A/P-loop; other site 474186001680 ATP binding site [chemical binding]; other site 474186001681 Q-loop/lid; other site 474186001682 ABC transporter signature motif; other site 474186001683 Walker B; other site 474186001684 D-loop; other site 474186001685 H-loop/switch region; other site 474186001686 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 474186001687 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 474186001688 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 474186001689 Walker A/P-loop; other site 474186001690 ATP binding site [chemical binding]; other site 474186001691 Q-loop/lid; other site 474186001692 ABC transporter signature motif; other site 474186001693 Walker B; other site 474186001694 D-loop; other site 474186001695 H-loop/switch region; other site 474186001696 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 474186001697 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 474186001698 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 474186001699 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 474186001700 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 474186001701 Walker A/P-loop; other site 474186001702 ATP binding site [chemical binding]; other site 474186001703 Q-loop/lid; other site 474186001704 ABC transporter signature motif; other site 474186001705 Walker B; other site 474186001706 D-loop; other site 474186001707 H-loop/switch region; other site 474186001708 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 474186001709 Putative rRNA methylase; Region: rRNA_methylase; pfam06962 474186001710 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 474186001711 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 474186001712 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 474186001713 active site 474186001714 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 474186001715 Protein of unknown function (DUF1700); Region: DUF1700; pfam08006 474186001716 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 474186001717 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 474186001718 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 474186001719 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 474186001720 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 474186001721 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 474186001722 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 474186001723 T-box leader; OG1RF_nc10006 474186001724 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 474186001725 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 474186001726 HIGH motif; other site 474186001727 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 474186001728 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 474186001729 active site 474186001730 KMSKS motif; other site 474186001731 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 474186001732 tRNA binding surface [nucleotide binding]; other site 474186001733 Protein of unknown function (DUF3955); Region: DUF3955; pfam13127 474186001734 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 474186001735 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 474186001736 substrate binding pocket [chemical binding]; other site 474186001737 membrane-bound complex binding site; other site 474186001738 hinge residues; other site 474186001739 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 474186001740 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 474186001741 Walker A/P-loop; other site 474186001742 ATP binding site [chemical binding]; other site 474186001743 Q-loop/lid; other site 474186001744 ABC transporter signature motif; other site 474186001745 Walker B; other site 474186001746 D-loop; other site 474186001747 H-loop/switch region; other site 474186001748 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 474186001749 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 474186001750 dimer interface [polypeptide binding]; other site 474186001751 conserved gate region; other site 474186001752 putative PBP binding loops; other site 474186001753 ABC-ATPase subunit interface; other site 474186001754 T-box leader; OG1RF_nc10007 474186001755 T-box leader; OG1RF_nc10008 474186001756 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 474186001757 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 474186001758 peptide binding site [polypeptide binding]; other site 474186001759 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 474186001760 Uncharacterized protein conserved in bacteria (DUF2264); Region: DUF2264; pfam10022 474186001761 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 474186001762 Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301 474186001763 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 474186001764 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 474186001765 DNA-binding site [nucleotide binding]; DNA binding site 474186001766 UTRA domain; Region: UTRA; pfam07702 474186001767 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 474186001768 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 474186001769 active pocket/dimerization site; other site 474186001770 active site 474186001771 phosphorylation site [posttranslational modification] 474186001772 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 474186001773 active site 474186001774 phosphorylation site [posttranslational modification] 474186001775 PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609 474186001776 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 474186001777 Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues; Region: GAG_Lyase; cd01083 474186001778 substrate binding site [chemical binding]; other site 474186001779 catalytic residues [active] 474186001780 Staphylococcal protein of unknown function (DUF960); Region: DUF960; pfam06124 474186001781 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 474186001782 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 474186001783 5S rRNA interface [nucleotide binding]; other site 474186001784 CTC domain interface [polypeptide binding]; other site 474186001785 L16 interface [polypeptide binding]; other site 474186001786 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 474186001787 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 474186001788 RNA binding surface [nucleotide binding]; other site 474186001789 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 474186001790 active site 474186001791 uracil binding [chemical binding]; other site 474186001792 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 474186001793 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 474186001794 motif II; other site 474186001795 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 474186001796 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 474186001797 Coenzyme A binding pocket [chemical binding]; other site 474186001798 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 474186001799 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 474186001800 Sugar specificity; other site 474186001801 Pyrimidine base specificity; other site 474186001802 ATP-binding site [chemical binding]; other site 474186001803 PemK-like protein; Region: PemK; pfam02452 474186001804 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 474186001805 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 474186001806 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 474186001807 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 474186001808 HTH domain; Region: HTH_11; pfam08279 474186001809 HTH domain; Region: HTH_11; pfam08279 474186001810 PRD domain; Region: PRD; pfam00874 474186001811 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 474186001812 active site 474186001813 P-loop; other site 474186001814 phosphorylation site [posttranslational modification] 474186001815 PRD domain protein EF_0829/AHA_3910; Region: EF_0829; TIGR03582 474186001816 Glycine-rich SFCGS; Region: Gly_rich_SFCGS; pfam14272 474186001817 conserved hypothetical protein EF_0831/AHA_3912; Region: EF_0831; TIGR03578 474186001818 Domain of unknown function (DUF4311); Region: DUF4311; cl11919 474186001819 Domain of unknown function (DUF4310); Region: DUF4310; cl11918 474186001820 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 474186001821 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 474186001822 Uncharacterized conserved protein [Function unknown]; Region: COG3589 474186001823 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 474186001824 probable amidohydrolase EF_0837/AHA_3915; Region: EF_0837; TIGR03583 474186001825 Metallo-dependent hydrolases, subgroup B is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_B; cd01307 474186001826 active site 474186001827 uncharacterized pyridoxal phosphate-dependent enzyme; Region: selA_rel; TIGR01437 474186001828 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 474186001829 catalytic residue [active] 474186001830 conserved hypothetical protein EF_0839/AHA_3917; Region: EF_0839; TIGR03581 474186001831 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 474186001832 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 474186001833 substrate binding site [chemical binding]; other site 474186001834 ATP binding site [chemical binding]; other site 474186001835 DNA gyrase B; Region: DNA_gyraseB; pfam00204 474186001836 ATP binding site [chemical binding]; other site 474186001837 hypothetical protein; Validated; Region: PRK00124 474186001838 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 474186001839 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 474186001840 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 474186001841 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 474186001842 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 474186001843 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 474186001844 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 474186001845 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 474186001846 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 474186001847 ATP binding site [chemical binding]; other site 474186001848 Mg++ binding site [ion binding]; other site 474186001849 motif III; other site 474186001850 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 474186001851 nucleotide binding region [chemical binding]; other site 474186001852 ATP-binding site [chemical binding]; other site 474186001853 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 474186001854 alanine racemase; Reviewed; Region: alr; PRK00053 474186001855 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 474186001856 active site 474186001857 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 474186001858 dimer interface [polypeptide binding]; other site 474186001859 substrate binding site [chemical binding]; other site 474186001860 catalytic residues [active] 474186001861 PemK-like protein; Region: PemK; pfam02452 474186001862 hypothetical protein; Provisional; Region: PRK11281 474186001863 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 474186001864 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 474186001865 Catalytic site [active] 474186001866 Mga helix-turn-helix domain; Region: Mga; pfam05043 474186001867 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 474186001868 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 474186001869 Predicted membrane protein [Function unknown]; Region: COG1511 474186001870 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 474186001871 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 474186001872 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 474186001873 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 474186001874 Amino acid permease; Region: AA_permease_2; pfam13520 474186001875 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 474186001876 Coenzyme A binding pocket [chemical binding]; other site 474186001877 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 474186001878 dimer interface [polypeptide binding]; other site 474186001879 conserved gate region; other site 474186001880 putative PBP binding loops; other site 474186001881 ABC-ATPase subunit interface; other site 474186001882 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 474186001883 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 474186001884 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 474186001885 dimer interface [polypeptide binding]; other site 474186001886 conserved gate region; other site 474186001887 putative PBP binding loops; other site 474186001888 ABC-ATPase subunit interface; other site 474186001889 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 474186001890 glycine betaine/L-proline transport ATP binding subunit; Region: proV; TIGR01186 474186001891 Walker A/P-loop; other site 474186001892 ATP binding site [chemical binding]; other site 474186001893 Q-loop/lid; other site 474186001894 ABC transporter signature motif; other site 474186001895 Walker B; other site 474186001896 D-loop; other site 474186001897 H-loop/switch region; other site 474186001898 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 474186001899 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 474186001900 Zn binding site [ion binding]; other site 474186001901 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 474186001902 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 474186001903 Zn binding site [ion binding]; other site 474186001904 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 474186001905 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 474186001906 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 474186001907 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 474186001908 salt bridge; other site 474186001909 non-specific DNA binding site [nucleotide binding]; other site 474186001910 sequence-specific DNA binding site [nucleotide binding]; other site 474186001911 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 474186001912 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 474186001913 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 474186001914 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 474186001915 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 474186001916 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 474186001917 K+ potassium transporter; Region: K_trans; pfam02705 474186001918 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 474186001919 non-specific DNA binding site [nucleotide binding]; other site 474186001920 salt bridge; other site 474186001921 sequence-specific DNA binding site [nucleotide binding]; other site 474186001922 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 474186001923 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 474186001924 Soluble P-type ATPase [General function prediction only]; Region: COG4087 474186001925 Mga helix-turn-helix domain; Region: Mga; pfam05043 474186001926 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 474186001927 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 474186001928 active site 474186001929 catalytic tetrad [active] 474186001930 DNA polymerase I; Provisional; Region: PRK05755 474186001931 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 474186001932 active site 474186001933 metal binding site 1 [ion binding]; metal-binding site 474186001934 putative 5' ssDNA interaction site; other site 474186001935 metal binding site 3; metal-binding site 474186001936 metal binding site 2 [ion binding]; metal-binding site 474186001937 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 474186001938 putative DNA binding site [nucleotide binding]; other site 474186001939 putative metal binding site [ion binding]; other site 474186001940 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 474186001941 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 474186001942 active site 474186001943 DNA binding site [nucleotide binding] 474186001944 catalytic site [active] 474186001945 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 474186001946 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 474186001947 DNA binding site [nucleotide binding] 474186001948 catalytic residue [active] 474186001949 H2TH interface [polypeptide binding]; other site 474186001950 putative catalytic residues [active] 474186001951 turnover-facilitating residue; other site 474186001952 intercalation triad [nucleotide binding]; other site 474186001953 8OG recognition residue [nucleotide binding]; other site 474186001954 putative reading head residues; other site 474186001955 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 474186001956 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 474186001957 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 474186001958 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 474186001959 CoA-binding site [chemical binding]; other site 474186001960 ATP-binding [chemical binding]; other site 474186001961 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 474186001962 ATP cone domain; Region: ATP-cone; pfam03477 474186001963 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 474186001964 primosomal protein DnaI; Reviewed; Region: PRK08939 474186001965 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 474186001966 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 474186001967 Walker A motif; other site 474186001968 ATP binding site [chemical binding]; other site 474186001969 Walker B motif; other site 474186001970 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 474186001971 Uncharacterized protein conserved in bacteria (DUF2334); Region: DUF2334; pfam10096 474186001972 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 474186001973 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 474186001974 DXD motif; other site 474186001975 Bacterial cellulose synthase subunit; Region: BcsB; cl15851 474186001976 Bacterial cellulose synthase subunit; Region: BcsB; cl15851 474186001977 aspartate aminotransferase; Provisional; Region: PRK06348 474186001978 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 474186001979 pyridoxal 5'-phosphate binding site [chemical binding]; other site 474186001980 homodimer interface [polypeptide binding]; other site 474186001981 catalytic residue [active] 474186001982 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 474186001983 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 474186001984 Walker A/P-loop; other site 474186001985 ATP binding site [chemical binding]; other site 474186001986 Q-loop/lid; other site 474186001987 ABC transporter signature motif; other site 474186001988 Walker B; other site 474186001989 D-loop; other site 474186001990 H-loop/switch region; other site 474186001991 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 474186001992 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 474186001993 substrate binding pocket [chemical binding]; other site 474186001994 membrane-bound complex binding site; other site 474186001995 hinge residues; other site 474186001996 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 474186001997 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 474186001998 dimer interface [polypeptide binding]; other site 474186001999 conserved gate region; other site 474186002000 ABC-ATPase subunit interface; other site 474186002001 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 474186002002 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 474186002003 putative active site [active] 474186002004 metal binding site [ion binding]; metal-binding site 474186002005 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 474186002006 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 474186002007 Preprotein translocase subunit; Region: YajC; pfam02699 474186002008 Post-transcriptional regulator; Region: Post_transc_reg; pfam13797 474186002009 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 474186002010 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 474186002011 putative catalytic cysteine [active] 474186002012 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 474186002013 putative active site [active] 474186002014 metal binding site [ion binding]; metal-binding site 474186002015 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 474186002016 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 474186002017 homotetramer interface [polypeptide binding]; other site 474186002018 FMN binding site [chemical binding]; other site 474186002019 homodimer contacts [polypeptide binding]; other site 474186002020 putative active site [active] 474186002021 putative substrate binding site [chemical binding]; other site 474186002022 phosphomevalonate kinase, ERG8-type, Gram-positive branch; Region: Pmev_kin_Gr_pos; TIGR01220 474186002023 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 474186002024 diphosphomevalonate decarboxylase; Region: mevDPdecarb; TIGR01240 474186002025 diphosphomevalonate decarboxylase; Region: PLN02407 474186002026 mevalonate kinase; Region: mevalon_kin; TIGR00549 474186002027 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 474186002028 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 474186002029 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 474186002030 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 474186002031 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 474186002032 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 474186002033 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 474186002034 peptide binding site [polypeptide binding]; other site 474186002035 Domain of unknown function (DUF3899); Region: DUF3899; pfam13038 474186002036 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 474186002037 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 474186002038 dimer interface [polypeptide binding]; other site 474186002039 conserved gate region; other site 474186002040 putative PBP binding loops; other site 474186002041 ABC-ATPase subunit interface; other site 474186002042 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 474186002043 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 474186002044 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 474186002045 dimer interface [polypeptide binding]; other site 474186002046 conserved gate region; other site 474186002047 putative PBP binding loops; other site 474186002048 ABC-ATPase subunit interface; other site 474186002049 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 474186002050 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 474186002051 Walker A/P-loop; other site 474186002052 ATP binding site [chemical binding]; other site 474186002053 Q-loop/lid; other site 474186002054 ABC transporter signature motif; other site 474186002055 Walker B; other site 474186002056 D-loop; other site 474186002057 H-loop/switch region; other site 474186002058 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 474186002059 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 474186002060 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 474186002061 Walker A/P-loop; other site 474186002062 ATP binding site [chemical binding]; other site 474186002063 Q-loop/lid; other site 474186002064 ABC transporter signature motif; other site 474186002065 Walker B; other site 474186002066 D-loop; other site 474186002067 H-loop/switch region; other site 474186002068 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 474186002069 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 474186002070 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 474186002071 Probable transposase; Region: OrfB_IS605; pfam01385 474186002072 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 474186002073 Ribosomal protein L20 leader; OG1RF_nc10009 474186002074 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 474186002075 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 474186002076 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 474186002077 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 474186002078 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 474186002079 23S rRNA binding site [nucleotide binding]; other site 474186002080 L21 binding site [polypeptide binding]; other site 474186002081 L13 binding site [polypeptide binding]; other site 474186002082 Protein of unknown function (DUF419); Region: DUF419; pfam04237 474186002083 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 474186002084 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 474186002085 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 474186002086 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 474186002087 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 474186002088 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 474186002089 Sulfate transporter family; Region: Sulfate_transp; pfam00916 474186002090 Conserved hypothetical protein 698; Region: Cons_hypoth698; pfam03601 474186002091 Transcriptional regulator [Transcription]; Region: LysR; COG0583 474186002092 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 474186002093 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 474186002094 dimerization interface [polypeptide binding]; other site 474186002095 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 474186002096 dimer interface [polypeptide binding]; other site 474186002097 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 474186002098 dimer interface [polypeptide binding]; other site 474186002099 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 474186002100 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 474186002101 active site 474186002102 phosphorylation site [posttranslational modification] 474186002103 intermolecular recognition site; other site 474186002104 dimerization interface [polypeptide binding]; other site 474186002105 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 474186002106 DNA binding site [nucleotide binding] 474186002107 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 474186002108 dimer interface [polypeptide binding]; other site 474186002109 His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388 474186002110 phosphorylation site [posttranslational modification] 474186002111 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 474186002112 ATP binding site [chemical binding]; other site 474186002113 Mg2+ binding site [ion binding]; other site 474186002114 G-X-G motif; other site 474186002115 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 474186002116 L-rhamnose-proton symport protein (RhaT); Region: RhaT; cl05728 474186002117 amino acid transporter; Region: 2A0306; TIGR00909 474186002118 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 474186002119 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 474186002120 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 474186002121 active site 474186002122 HIGH motif; other site 474186002123 KMSKS motif; other site 474186002124 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 474186002125 tRNA binding surface [nucleotide binding]; other site 474186002126 anticodon binding site; other site 474186002127 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 474186002128 dimer interface [polypeptide binding]; other site 474186002129 putative tRNA-binding site [nucleotide binding]; other site 474186002130 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 474186002131 Part of AAA domain; Region: AAA_19; pfam13245 474186002132 Family description; Region: UvrD_C_2; pfam13538 474186002133 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 474186002134 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 474186002135 active site 474186002136 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 474186002137 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 474186002138 putative active site [active] 474186002139 putative metal binding site [ion binding]; other site 474186002140 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 474186002141 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 474186002142 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 474186002143 S-adenosylmethionine binding site [chemical binding]; other site 474186002144 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 474186002145 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 474186002146 Walker A/P-loop; other site 474186002147 ATP binding site [chemical binding]; other site 474186002148 Q-loop/lid; other site 474186002149 ABC transporter signature motif; other site 474186002150 Walker B; other site 474186002151 D-loop; other site 474186002152 H-loop/switch region; other site 474186002153 TOBE domain; Region: TOBE_2; pfam08402 474186002154 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 474186002155 active site 474186002156 dimer interfaces [polypeptide binding]; other site 474186002157 catalytic residues [active] 474186002158 hypothetical protein; Provisional; Region: PRK09609 474186002159 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 474186002160 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 474186002161 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 474186002162 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 474186002163 Walker A/P-loop; other site 474186002164 ATP binding site [chemical binding]; other site 474186002165 Q-loop/lid; other site 474186002166 ABC transporter signature motif; other site 474186002167 Walker B; other site 474186002168 D-loop; other site 474186002169 H-loop/switch region; other site 474186002170 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 474186002171 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 474186002172 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 474186002173 Walker A/P-loop; other site 474186002174 ATP binding site [chemical binding]; other site 474186002175 Q-loop/lid; other site 474186002176 ABC transporter signature motif; other site 474186002177 Walker B; other site 474186002178 D-loop; other site 474186002179 H-loop/switch region; other site 474186002180 Predicted membrane protein [Function unknown]; Region: COG4905 474186002181 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 474186002182 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 474186002183 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 474186002184 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 474186002185 Coenzyme A binding pocket [chemical binding]; other site 474186002186 Tubby C 2; Region: Tub_2; cl02043 474186002187 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 474186002188 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 474186002189 active site 474186002190 motif I; other site 474186002191 motif II; other site 474186002192 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 474186002193 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 474186002194 ligand binding site [chemical binding]; other site 474186002195 active site 474186002196 UGI interface [polypeptide binding]; other site 474186002197 catalytic site [active] 474186002198 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 474186002199 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 474186002200 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 474186002201 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 474186002202 Coenzyme A binding pocket [chemical binding]; other site 474186002203 Transcriptional regulators [Transcription]; Region: PurR; COG1609 474186002204 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 474186002205 DNA binding site [nucleotide binding] 474186002206 domain linker motif; other site 474186002207 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 474186002208 putative dimerization interface [polypeptide binding]; other site 474186002209 putative ligand binding site [chemical binding]; other site 474186002210 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 474186002211 active site 474186002212 catalytic residues [active] 474186002213 beta-phosphoglucomutase; Region: bPGM; TIGR01990 474186002214 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 474186002215 motif II; other site 474186002216 maltose phosphorylase; Provisional; Region: PRK13807 474186002217 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 474186002218 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 474186002219 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 474186002220 PTS system, IIBC component; Region: PTS-II-BC-unk1; TIGR02003 474186002221 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 474186002222 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 474186002223 active site turn [active] 474186002224 phosphorylation site [posttranslational modification] 474186002225 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 474186002226 HPr interaction site; other site 474186002227 glycerol kinase (GK) interaction site [polypeptide binding]; other site 474186002228 active site 474186002229 phosphorylation site [posttranslational modification] 474186002230 Streptococcus agalactiae RgfB, part of a putative two component signal transduction system, and related proteins; Region: RgfB-like; cd09079 474186002231 putative catalytic site [active] 474186002232 putative metal binding site [ion binding]; other site 474186002233 putative phosphate binding site [ion binding]; other site 474186002234 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 474186002235 pyrroline-5-carboxylate reductase; Region: proC; TIGR00112 474186002236 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 474186002237 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 474186002238 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537 474186002239 homodimer interface [polypeptide binding]; other site 474186002240 chemical substrate binding site [chemical binding]; other site 474186002241 oligomer interface [polypeptide binding]; other site 474186002242 metal binding site [ion binding]; metal-binding site 474186002243 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 474186002244 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 474186002245 active site 474186002246 Protein of unknown function (DUF2974); Region: DUF2974; pfam11187 474186002247 Ribosomal protein L21 leader; OG1RF_nc10010 474186002248 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 474186002249 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 474186002250 Protein of unknown function (DUF464); Region: DUF464; pfam04327 474186002251 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 474186002252 phosphate-starvation-inducible protein PsiE; Provisional; Region: PRK02833 474186002253 phosphodiesterase YaeI; Provisional; Region: PRK11340 474186002254 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 474186002255 putative active site [active] 474186002256 putative metal binding site [ion binding]; other site 474186002257 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 474186002258 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 474186002259 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 474186002260 active site 474186002261 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cd11523 474186002262 metal binding site [ion binding]; metal-binding site 474186002263 Asp23 family; Region: Asp23; pfam03780 474186002264 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 474186002265 putative RNA binding site [nucleotide binding]; other site 474186002266 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14179 474186002267 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 474186002268 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 474186002269 homodimer interface [polypeptide binding]; other site 474186002270 NADP binding site [chemical binding]; other site 474186002271 substrate binding site [chemical binding]; other site 474186002272 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 474186002273 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 474186002274 generic binding surface II; other site 474186002275 generic binding surface I; other site 474186002276 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 474186002277 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 474186002278 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 474186002279 substrate binding pocket [chemical binding]; other site 474186002280 chain length determination region; other site 474186002281 substrate-Mg2+ binding site; other site 474186002282 catalytic residues [active] 474186002283 aspartate-rich region 1; other site 474186002284 active site lid residues [active] 474186002285 aspartate-rich region 2; other site 474186002286 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 474186002287 S4 RNA-binding domain; Region: S4; smart00363 474186002288 RNA binding surface [nucleotide binding]; other site 474186002289 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 474186002290 Arginine repressor [Transcription]; Region: ArgR; COG1438 474186002291 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 474186002292 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 474186002293 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 474186002294 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 474186002295 Walker A/P-loop; other site 474186002296 ATP binding site [chemical binding]; other site 474186002297 Q-loop/lid; other site 474186002298 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 474186002299 ABC transporter signature motif; other site 474186002300 Walker B; other site 474186002301 D-loop; other site 474186002302 H-loop/switch region; other site 474186002303 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 474186002304 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 474186002305 Cl binding site [ion binding]; other site 474186002306 oligomer interface [polypeptide binding]; other site 474186002307 Protein of unknown function (DUF3397); Region: DUF3397; pfam11877 474186002308 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001 474186002309 MraZ protein; Region: MraZ; pfam02381 474186002310 MraZ protein; Region: MraZ; pfam02381 474186002311 MraW methylase family; Region: Methyltransf_5; pfam01795 474186002312 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 474186002313 Cell division protein FtsL; Region: FtsL; cl11433 474186002314 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 474186002315 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 474186002316 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 474186002317 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 474186002318 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 474186002319 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 474186002320 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 474186002321 Mg++ binding site [ion binding]; other site 474186002322 putative catalytic motif [active] 474186002323 putative substrate binding site [chemical binding]; other site 474186002324 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 474186002325 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002 474186002326 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 474186002327 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 474186002328 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 474186002329 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 474186002330 active site 474186002331 homodimer interface [polypeptide binding]; other site 474186002332 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 474186002333 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 474186002334 Cell division protein FtsQ; Region: FtsQ; pfam03799 474186002335 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 474186002336 Cell division protein FtsA; Region: FtsA; smart00842 474186002337 Cell division protein FtsA; Region: FtsA; pfam14450 474186002338 Domain of unknown function (DUF3484); Region: DUF3484; pfam11983 474186002339 cell division protein FtsZ; Validated; Region: PRK09330 474186002340 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 474186002341 nucleotide binding site [chemical binding]; other site 474186002342 SulA interaction site; other site 474186002343 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 474186002344 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 474186002345 catalytic residue [active] 474186002346 Protein of unknown function (DUF552); Region: DUF552; pfam04472 474186002347 YGGT family; Region: YGGT; pfam02325 474186002348 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 474186002349 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 474186002350 RNA binding surface [nucleotide binding]; other site 474186002351 DivIVA protein; Region: DivIVA; pfam05103 474186002352 DivIVA domain; Region: DivI1A_domain; TIGR03544 474186002353 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 474186002354 T-box leader; OG1RF_nc10011 474186002355 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 474186002356 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 474186002357 active site 474186002358 HIGH motif; other site 474186002359 nucleotide binding site [chemical binding]; other site 474186002360 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 474186002361 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 474186002362 active site 474186002363 KMSKS motif; other site 474186002364 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 474186002365 tRNA binding surface [nucleotide binding]; other site 474186002366 anticodon binding site; other site 474186002367 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 474186002368 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 474186002369 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 474186002370 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 474186002371 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 474186002372 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 474186002373 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 474186002374 FeoA domain; Region: FeoA; pfam04023 474186002375 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 474186002376 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 474186002377 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 474186002378 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 474186002379 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 474186002380 ATP binding site [chemical binding]; other site 474186002381 putative Mg++ binding site [ion binding]; other site 474186002382 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 474186002383 nucleotide binding region [chemical binding]; other site 474186002384 ATP-binding site [chemical binding]; other site 474186002385 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 474186002386 putative Zn2+ binding site [ion binding]; other site 474186002387 putative DNA binding site [nucleotide binding]; other site 474186002388 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 474186002389 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 474186002390 Walker A motif; other site 474186002391 ATP binding site [chemical binding]; other site 474186002392 Walker B motif; other site 474186002393 arginine finger; other site 474186002394 Transcriptional antiterminator [Transcription]; Region: COG3933 474186002395 PRD domain; Region: PRD; pfam00874 474186002396 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 474186002397 active pocket/dimerization site; other site 474186002398 active site 474186002399 phosphorylation site [posttranslational modification] 474186002400 PRD domain; Region: PRD; pfam00874 474186002401 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 474186002402 active site 474186002403 P-loop; other site 474186002404 phosphorylation site [posttranslational modification] 474186002405 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 474186002406 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 474186002407 Domain of unknown function (DUF3284); Region: DUF3284; pfam11687 474186002408 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 474186002409 active site 474186002410 P-loop; other site 474186002411 phosphorylation site [posttranslational modification] 474186002412 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 474186002413 active site 474186002414 methionine cluster; other site 474186002415 phosphorylation site [posttranslational modification] 474186002416 metal binding site [ion binding]; metal-binding site 474186002417 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 474186002418 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 474186002419 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 474186002420 beta-galactosidase; Region: BGL; TIGR03356 474186002421 Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527 474186002422 Sterol carrier protein domain; Region: SCP2_2; pfam13530 474186002423 Uncharacterized conserved protein [Function unknown]; Region: COG1359 474186002424 pyruvate, phosphate dikinase; Region: pyru_phos_dikin; TIGR01828 474186002425 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 474186002426 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 474186002427 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 474186002428 HTH domain; Region: HTH_11; pfam08279 474186002429 FOG: CBS domain [General function prediction only]; Region: COG0517 474186002430 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 474186002431 Kinase/pyrophosphorylase; Region: Kinase-PPPase; pfam03618 474186002432 Predicted integral membrane protein [Function unknown]; Region: COG0392 474186002433 Uncharacterized conserved protein [Function unknown]; Region: COG2898 474186002434 Keratinocyte-associated protein 2; Region: Keratin_assoc; pfam09775 474186002435 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 474186002436 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 474186002437 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 474186002438 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 474186002439 putative catalytic site [active] 474186002440 putative metal binding site [ion binding]; other site 474186002441 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 474186002442 putative catalytic site [active] 474186002443 putative phosphate binding site [ion binding]; other site 474186002444 putative phosphate binding site [ion binding]; other site 474186002445 putative metal binding site [ion binding]; other site 474186002446 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Provisional; Region: PRK07164 474186002447 Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048 474186002448 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 474186002449 Walker A/P-loop; other site 474186002450 ATP binding site [chemical binding]; other site 474186002451 Q-loop/lid; other site 474186002452 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 474186002453 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 474186002454 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 474186002455 Walker A/P-loop; other site 474186002456 ATP binding site [chemical binding]; other site 474186002457 Q-loop/lid; other site 474186002458 ABC transporter signature motif; other site 474186002459 Walker B; other site 474186002460 D-loop; other site 474186002461 H-loop/switch region; other site 474186002462 amidase; Provisional; Region: PRK06529 474186002463 Amidase; Region: Amidase; cl11426 474186002464 Phosphotransferase enzyme family; Region: APH; pfam01636 474186002465 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 474186002466 active site 474186002467 ATP binding site [chemical binding]; other site 474186002468 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 474186002469 active site 474186002470 multimer interface [polypeptide binding]; other site 474186002471 aspartate 4-decarboxylase; Region: asp_4_decarbox; TIGR03801 474186002472 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 474186002473 pyridoxal 5'-phosphate binding site [chemical binding]; other site 474186002474 homodimer interface [polypeptide binding]; other site 474186002475 catalytic residue [active] 474186002476 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 474186002477 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 474186002478 active site 474186002479 motif I; other site 474186002480 motif II; other site 474186002481 Protein of unknown function (DUF1361); Region: DUF1361; pfam07099 474186002482 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 474186002483 drug efflux system protein MdtG; Provisional; Region: PRK09874 474186002484 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 474186002485 putative substrate translocation pore; other site 474186002486 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 474186002487 DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587 474186002488 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 474186002489 active site 474186002490 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 474186002491 generic binding surface II; other site 474186002492 generic binding surface I; other site 474186002493 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 474186002494 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 474186002495 active site 474186002496 ADP/pyrophosphate binding site [chemical binding]; other site 474186002497 dimerization interface [polypeptide binding]; other site 474186002498 allosteric effector site; other site 474186002499 fructose-1,6-bisphosphate binding site; other site 474186002500 pyruvate kinase; Provisional; Region: PRK06354 474186002501 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 474186002502 domain interfaces; other site 474186002503 active site 474186002504 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 474186002505 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 474186002506 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 474186002507 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 474186002508 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 474186002509 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 474186002510 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 474186002511 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 474186002512 active site 474186002513 phosphorylation site [posttranslational modification] 474186002514 intermolecular recognition site; other site 474186002515 dimerization interface [polypeptide binding]; other site 474186002516 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 474186002517 DNA binding site [nucleotide binding] 474186002518 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 474186002519 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 474186002520 dimerization interface [polypeptide binding]; other site 474186002521 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 474186002522 dimer interface [polypeptide binding]; other site 474186002523 phosphorylation site [posttranslational modification] 474186002524 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 474186002525 ATP binding site [chemical binding]; other site 474186002526 Mg2+ binding site [ion binding]; other site 474186002527 G-X-G motif; other site 474186002528 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 474186002529 Cna protein B-type domain; Region: Cna_B; pfam05738 474186002530 Bacterial protein of unknown function (DUF961); Region: DUF961; pfam06125 474186002531 Bacterial protein of unknown function (DUF961); Region: DUF961; pfam06125 474186002532 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 474186002533 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 474186002534 Walker A motif; other site 474186002535 ATP binding site [chemical binding]; other site 474186002536 Walker B motif; other site 474186002537 arginine finger; other site 474186002538 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 474186002539 C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145 474186002540 cofactor binding site; other site 474186002541 DNA binding site [nucleotide binding] 474186002542 substrate interaction site [chemical binding]; other site 474186002543 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 474186002544 non-specific DNA binding site [nucleotide binding]; other site 474186002545 salt bridge; other site 474186002546 sequence-specific DNA binding site [nucleotide binding]; other site 474186002547 Replication initiation factor; Region: Rep_trans; pfam02486 474186002548 Antirestriction protein (ArdA); Region: ArdA; pfam07275 474186002549 Restriction endonuclease; Region: Mrr_cat; pfam04471 474186002550 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 474186002551 Walker A/P-loop; other site 474186002552 ATP binding site [chemical binding]; other site 474186002553 TcpE family; Region: TcpE; pfam12648 474186002554 TcpE family; Region: TcpE; pfam12648 474186002555 AAA-like domain; Region: AAA_10; pfam12846 474186002556 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; pfam04610 474186002557 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 474186002558 N-acetyl-D-glucosamine binding site [chemical binding]; other site 474186002559 catalytic residue [active] 474186002560 NlpC/P60 family; Region: NLPC_P60; pfam00877 474186002561 Conjugative transposon protein TcpC; Region: TpcC; pfam12642 474186002562 Divergent AAA domain; Region: AAA_4; pfam04326 474186002563 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 474186002564 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 474186002565 active site 474186002566 motif I; other site 474186002567 motif II; other site 474186002568 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 474186002569 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 474186002570 glutathionine S-transferase; Provisional; Region: PRK10542 474186002571 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 474186002572 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 474186002573 dimer interface [polypeptide binding]; other site 474186002574 substrate binding pocket (H-site) [chemical binding]; other site 474186002575 N-terminal domain interface [polypeptide binding]; other site 474186002576 Mga helix-turn-helix domain; Region: Mga; pfam05043 474186002577 Cna protein B-type domain; Region: Cna_B; pfam05738 474186002578 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 474186002579 Cna protein B-type domain; Region: Cna_B; pfam05738 474186002580 Cna protein B-type domain; Region: Cna_B; pfam05738 474186002581 Cna protein B-type domain; Region: Cna_B; pfam05738 474186002582 Cna protein B-type domain; Region: Cna_B; pfam05738 474186002583 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 474186002584 Cna protein B-type domain; Region: Cna_B; pfam05738 474186002585 Cna protein B-type domain; Region: Cna_B; pfam05738 474186002586 Cna protein B-type domain; Region: Cna_B; pfam05738 474186002587 Cna protein B-type domain; Region: Cna_B; pfam05738 474186002588 Cna protein B-type domain; Region: Cna_B; pfam05738 474186002589 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 474186002590 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 474186002591 DNA binding residues [nucleotide binding] 474186002592 Helix-turn-helix domain; Region: HTH_16; pfam12645 474186002593 Predicted transcriptional regulators [Transcription]; Region: COG1733 474186002594 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 474186002595 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 474186002596 dimer interface [polypeptide binding]; other site 474186002597 FMN binding site [chemical binding]; other site 474186002598 Protein of unknown function (DUF3021); Region: DUF3021; pfam11457 474186002599 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 474186002600 LytTr DNA-binding domain; Region: LytTR; smart00850 474186002601 AAA ATPase domain; Region: AAA_15; pfam13175 474186002602 Protein of unknown function (DUF2813); Region: DUF2813; pfam11398 474186002603 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 474186002604 putative active site [active] 474186002605 putative metal-binding site [ion binding]; other site 474186002606 Part of AAA domain; Region: AAA_19; pfam13245 474186002607 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 474186002608 Family description; Region: UvrD_C_2; pfam13538 474186002609 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 474186002610 dimer interface [polypeptide binding]; other site 474186002611 Domain of unknown function (DUF771); Region: DUF771; cl09962 474186002612 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 474186002613 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 474186002614 active site 474186002615 DNA binding site [nucleotide binding] 474186002616 Int/Topo IB signature motif; other site 474186002617 ykoK leader; OG1RF_nc10013 474186002618 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 474186002619 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 474186002620 Walker A/P-loop; other site 474186002621 ATP binding site [chemical binding]; other site 474186002622 Q-loop/lid; other site 474186002623 ABC transporter signature motif; other site 474186002624 Walker B; other site 474186002625 D-loop; other site 474186002626 H-loop/switch region; other site 474186002627 ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism]; Region: COG4986 474186002628 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 474186002629 dimer interface [polypeptide binding]; other site 474186002630 conserved gate region; other site 474186002631 putative PBP binding loops; other site 474186002632 ABC-ATPase subunit interface; other site 474186002633 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 474186002634 dimer interface [polypeptide binding]; other site 474186002635 conserved gate region; other site 474186002636 ABC-ATPase subunit interface; other site 474186002637 ykoK leader; OG1RF_nc10014 474186002638 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 474186002639 AAA domain; Region: AAA_18; pfam13238 474186002640 active site 474186002641 manganese transport protein MntH; Reviewed; Region: PRK00701 474186002642 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 474186002643 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 474186002644 Ligand Binding Site [chemical binding]; other site 474186002645 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 474186002646 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 474186002647 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 474186002648 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 474186002649 peptide binding site [polypeptide binding]; other site 474186002650 putative deaminase; Validated; Region: PRK06846 474186002651 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 474186002652 active site 474186002653 putative deaminase; Validated; Region: PRK06846 474186002654 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 474186002655 active site 474186002656 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 474186002657 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 474186002658 dimer interface [polypeptide binding]; other site 474186002659 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 474186002660 maltose O-acetyltransferase; Provisional; Region: PRK10092 474186002661 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 474186002662 active site 474186002663 substrate binding site [chemical binding]; other site 474186002664 trimer interface [polypeptide binding]; other site 474186002665 CoA binding site [chemical binding]; other site 474186002666 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 474186002667 active site 474186002668 catalytic residues [active] 474186002669 galactokinase; Provisional; Region: PRK05322 474186002670 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 474186002671 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 474186002672 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 474186002673 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 474186002674 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 474186002675 NAD binding site [chemical binding]; other site 474186002676 homodimer interface [polypeptide binding]; other site 474186002677 active site 474186002678 substrate binding site [chemical binding]; other site 474186002679 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 474186002680 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 474186002681 Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744 474186002682 Transcriptional regulators [Transcription]; Region: PurR; COG1609 474186002683 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 474186002684 DNA binding site [nucleotide binding] 474186002685 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 474186002686 putative ligand binding site [chemical binding]; other site 474186002687 putative dimerization interface [polypeptide binding]; other site 474186002688 hypothetical protein; Provisional; Region: PRK06762 474186002689 AAA domain; Region: AAA_33; pfam13671 474186002690 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 474186002691 Coenzyme A binding pocket [chemical binding]; other site 474186002692 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 474186002693 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 474186002694 active site 474186002695 NTP binding site [chemical binding]; other site 474186002696 metal binding triad [ion binding]; metal-binding site 474186002697 Domain of unknown function (DUF4111); Region: DUF4111; pfam13427 474186002698 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 474186002699 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 474186002700 Coenzyme A binding pocket [chemical binding]; other site 474186002701 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 474186002702 putative substrate translocation pore; other site 474186002703 Major Facilitator Superfamily; Region: MFS_1; pfam07690 474186002704 DNA polymerase IV; Reviewed; Region: PRK03103 474186002705 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 474186002706 active site 474186002707 DNA binding site [nucleotide binding] 474186002708 Protein of unknown function (DUF3016); Region: DUF3016; pfam11454 474186002709 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 474186002710 Ligand Binding Site [chemical binding]; other site 474186002711 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 474186002712 Coenzyme A binding pocket [chemical binding]; other site 474186002713 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 474186002714 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 474186002715 Protein of unknown function (DUF805); Region: DUF805; pfam05656 474186002716 Mga helix-turn-helix domain; Region: Mga; pfam05043 474186002717 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 474186002718 metal ion-dependent adhesion site (MIDAS); other site 474186002719 Cna protein B-type domain; Region: Cna_B; pfam05738 474186002720 Cna protein B-type domain; Region: Cna_B; pfam05738 474186002721 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 474186002722 Cna protein B-type domain; Region: Cna_B; pfam05738 474186002723 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 474186002724 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 474186002725 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 474186002726 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 474186002727 active site 474186002728 catalytic site [active] 474186002729 Domain of unknown function (DUF378); Region: DUF378; pfam04070 474186002730 Bacterial protein of unknown function (DUF898); Region: DUF898; cl01738 474186002731 Collagen binding domain; Region: Collagen_bind; pfam05737 474186002732 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 474186002733 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 474186002734 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 474186002735 Walker A/P-loop; other site 474186002736 ATP binding site [chemical binding]; other site 474186002737 Q-loop/lid; other site 474186002738 ABC transporter signature motif; other site 474186002739 Walker B; other site 474186002740 D-loop; other site 474186002741 H-loop/switch region; other site 474186002742 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 474186002743 S-adenosylmethionine binding site [chemical binding]; other site 474186002744 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 474186002745 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 474186002746 CoB--CoM heterodisulfide reductase, subunit B; Region: CoB_CoM_SS_B; TIGR03288 474186002747 Cysteine-rich domain; Region: CCG; pfam02754 474186002748 Cysteine-rich domain; Region: CCG; pfam02754 474186002749 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 474186002750 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 474186002751 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 474186002752 Uncharacterized conserved protein [Function unknown]; Region: COG1556 474186002753 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 474186002754 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 474186002755 Catalytic site [active] 474186002756 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 474186002757 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 474186002758 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 474186002759 Part of AAA domain; Region: AAA_19; pfam13245 474186002760 Family description; Region: UvrD_C_2; pfam13538 474186002761 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 474186002762 Predicted transcriptional regulators [Transcription]; Region: COG1733 474186002763 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 474186002764 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 474186002765 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 474186002766 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 474186002767 dimer interface [polypeptide binding]; other site 474186002768 motif 1; other site 474186002769 active site 474186002770 motif 2; other site 474186002771 motif 3; other site 474186002772 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 474186002773 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 474186002774 putative tRNA-binding site [nucleotide binding]; other site 474186002775 B3/4 domain; Region: B3_4; pfam03483 474186002776 tRNA synthetase B5 domain; Region: B5; smart00874 474186002777 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 474186002778 dimer interface [polypeptide binding]; other site 474186002779 motif 1; other site 474186002780 motif 3; other site 474186002781 motif 2; other site 474186002782 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 474186002783 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 474186002784 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 474186002785 dimer interface [polypeptide binding]; other site 474186002786 conserved gate region; other site 474186002787 putative PBP binding loops; other site 474186002788 ABC-ATPase subunit interface; other site 474186002789 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 474186002790 dimer interface [polypeptide binding]; other site 474186002791 conserved gate region; other site 474186002792 putative PBP binding loops; other site 474186002793 ABC-ATPase subunit interface; other site 474186002794 bifunctional adhesin/ABC transporter aspartate/glutamate-binding protein; Reviewed; Region: PRK11917 474186002795 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 474186002796 substrate binding pocket [chemical binding]; other site 474186002797 membrane-bound complex binding site; other site 474186002798 hinge residues; other site 474186002799 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 474186002800 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 474186002801 Walker A/P-loop; other site 474186002802 ATP binding site [chemical binding]; other site 474186002803 Q-loop/lid; other site 474186002804 ABC transporter signature motif; other site 474186002805 Walker B; other site 474186002806 D-loop; other site 474186002807 H-loop/switch region; other site 474186002808 glutamate racemase; Provisional; Region: PRK00865 474186002809 ribonuclease PH; Reviewed; Region: rph; PRK00173 474186002810 Ribonuclease PH; Region: RNase_PH_bact; cd11362 474186002811 hexamer interface [polypeptide binding]; other site 474186002812 active site 474186002813 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 474186002814 active site 474186002815 dimerization interface [polypeptide binding]; other site 474186002816 Predicted phosphoesterases, related to the Icc protein [General function prediction only]; Region: COG2129 474186002817 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 474186002818 active site 474186002819 metal binding site [ion binding]; metal-binding site 474186002820 homotetramer interface [polypeptide binding]; other site 474186002821 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 474186002822 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 474186002823 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 474186002824 putative L-ascorbate 6-phosphate lactonase; Provisional; Region: PRK11709 474186002825 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 474186002826 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 474186002827 active site 474186002828 phosphorylation site [posttranslational modification] 474186002829 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: PRK12997 474186002830 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 474186002831 active site 474186002832 P-loop; other site 474186002833 phosphorylation site [posttranslational modification] 474186002834 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 474186002835 active site 474186002836 dimer interface [polypeptide binding]; other site 474186002837 magnesium binding site [ion binding]; other site 474186002838 putative L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13210 474186002839 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 474186002840 AP (apurinic/apyrimidinic) site pocket; other site 474186002841 DNA interaction; other site 474186002842 Metal-binding active site; metal-binding site 474186002843 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 474186002844 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 474186002845 intersubunit interface [polypeptide binding]; other site 474186002846 active site 474186002847 Zn2+ binding site [ion binding]; other site 474186002848 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 474186002849 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 474186002850 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 474186002851 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 474186002852 active site 474186002853 trimer interface [polypeptide binding]; other site 474186002854 substrate binding site [chemical binding]; other site 474186002855 CoA binding site [chemical binding]; other site 474186002856 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 474186002857 M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670 474186002858 metal binding site [ion binding]; metal-binding site 474186002859 putative dimer interface [polypeptide binding]; other site 474186002860 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 474186002861 Mechanosensitive ion channel; Region: MS_channel; pfam00924 474186002862 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 474186002863 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 474186002864 active site 474186002865 catalytic tetrad [active] 474186002866 Peptidase C26; Region: Peptidase_C26; pfam07722 474186002867 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 474186002868 catalytic triad [active] 474186002869 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 474186002870 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 474186002871 dimer interface [polypeptide binding]; other site 474186002872 active site 474186002873 metal binding site [ion binding]; metal-binding site 474186002874 glutathione binding site [chemical binding]; other site 474186002875 Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684 474186002876 nudix motif; other site 474186002877 sugar phosphate phosphatase; Provisional; Region: PRK10513 474186002878 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 474186002879 active site 474186002880 motif I; other site 474186002881 motif II; other site 474186002882 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 474186002883 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 474186002884 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 474186002885 Zn2+ binding site [ion binding]; other site 474186002886 Mg2+ binding site [ion binding]; other site 474186002887 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 474186002888 Domain of unknown function (DUF1934); Region: DUF1934; pfam09148 474186002889 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066 474186002890 CTP synthetase; Validated; Region: pyrG; PRK05380 474186002891 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 474186002892 Catalytic site [active] 474186002893 active site 474186002894 UTP binding site [chemical binding]; other site 474186002895 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 474186002896 active site 474186002897 putative oxyanion hole; other site 474186002898 catalytic triad [active] 474186002899 Transglycosylase; Region: Transgly; pfam00912 474186002900 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 474186002901 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 474186002902 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 474186002903 hypothetical protein; Provisional; Region: PRK13660 474186002904 cell division protein GpsB; Provisional; Region: PRK14127 474186002905 DivIVA domain; Region: DivI1A_domain; TIGR03544 474186002906 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 474186002907 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 474186002908 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 474186002909 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 474186002910 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 474186002911 active site 474186002912 Zn binding site [ion binding]; other site 474186002913 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 474186002914 Helix-turn-helix domain; Region: HTH_36; pfam13730 474186002915 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 474186002916 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 474186002917 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 474186002918 minor groove reading motif; other site 474186002919 helix-hairpin-helix signature motif; other site 474186002920 substrate binding pocket [chemical binding]; other site 474186002921 active site 474186002922 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 474186002923 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 474186002924 DNA-binding site [nucleotide binding]; DNA binding site 474186002925 UTRA domain; Region: UTRA; pfam07702 474186002926 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 474186002927 dipeptidase, putative; Region: dipeptidaselike; TIGR01887 474186002928 active site 474186002929 metal binding site [ion binding]; metal-binding site 474186002930 Glycosylasparaginase catalyzes the hydrolysis of the glycosylamide bond of asparagine-linked glycoproteins. This enzyme is an amidase located inside lysosomes. Mutation of this gene in humans causes a genetic disorder known as aspartylglycosaminuria (AGU)...; Region: Glycosylasparaginase; cd04513 474186002931 active site 474186002932 dimer interface [polypeptide binding]; other site 474186002933 catalytic nucleophile [active] 474186002934 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 474186002935 active site 474186002936 P-loop; other site 474186002937 phosphorylation site [posttranslational modification] 474186002938 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 474186002939 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 474186002940 glycine reductase, selenoprotein B; Region: gly_red_sel_B; TIGR01917 474186002941 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 474186002942 DEAD/DEAH box helicase; Region: DEAD; pfam00270 474186002943 ATP binding site [chemical binding]; other site 474186002944 DEAD_2; Region: DEAD_2; pfam06733 474186002945 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 474186002946 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 474186002947 active site 474186002948 homotetramer interface [polypeptide binding]; other site 474186002949 homodimer interface [polypeptide binding]; other site 474186002950 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 474186002951 Zn2+ binding site [ion binding]; other site 474186002952 Mg2+ binding site [ion binding]; other site 474186002953 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 474186002954 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 474186002955 Uncharacterized conserved protein [Function unknown]; Region: COG1284 474186002956 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 474186002957 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 474186002958 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 474186002959 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 474186002960 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 474186002961 intersubunit interface [polypeptide binding]; other site 474186002962 active site 474186002963 zinc binding site [ion binding]; other site 474186002964 Na+ binding site [ion binding]; other site 474186002965 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 474186002966 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 474186002967 hinge; other site 474186002968 active site 474186002969 transcription termination factor Rho; Provisional; Region: rho; PRK09376 474186002970 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 474186002971 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 474186002972 RNA binding site [nucleotide binding]; other site 474186002973 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 474186002974 multimer interface [polypeptide binding]; other site 474186002975 Walker A motif; other site 474186002976 ATP binding site [chemical binding]; other site 474186002977 Walker B motif; other site 474186002978 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 474186002979 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 474186002980 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 474186002981 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 474186002982 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 474186002983 nucleotide binding site [chemical binding]; other site 474186002984 CsbD-like; Region: CsbD; cl17424 474186002985 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 474186002986 dimer interface [polypeptide binding]; other site 474186002987 FMN binding site [chemical binding]; other site 474186002988 NADPH bind site [chemical binding]; other site 474186002989 S-ribosylhomocysteinase; Provisional; Region: PRK02260 474186002990 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 474186002991 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 474186002992 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 474186002993 dihydrodipicolinate synthase; Region: dapA; TIGR00674 474186002994 dimer interface [polypeptide binding]; other site 474186002995 active site 474186002996 catalytic residue [active] 474186002997 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 474186002998 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 474186002999 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 474186003000 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 474186003001 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 474186003002 active site 474186003003 metal binding site [ion binding]; metal-binding site 474186003004 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 474186003005 Protein of unknown function (DUF1027); Region: DUF1027; pfam06265 474186003006 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 474186003007 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 474186003008 active site 474186003009 motif I; other site 474186003010 motif II; other site 474186003011 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 474186003012 integral membrane protein TIGR01906; Region: integ_TIGR01906 474186003013 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 474186003014 EDD domain protein, DegV family; Region: DegV; TIGR00762 474186003015 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 474186003016 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 474186003017 amphipathic channel; other site 474186003018 Asn-Pro-Ala signature motifs; other site 474186003019 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 474186003020 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 474186003021 active site 474186003022 phosphorylation site [posttranslational modification] 474186003023 intermolecular recognition site; other site 474186003024 dimerization interface [polypeptide binding]; other site 474186003025 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 474186003026 DNA binding site [nucleotide binding] 474186003027 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 474186003028 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 474186003029 dimerization interface [polypeptide binding]; other site 474186003030 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 474186003031 putative active site [active] 474186003032 heme pocket [chemical binding]; other site 474186003033 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 474186003034 dimer interface [polypeptide binding]; other site 474186003035 phosphorylation site [posttranslational modification] 474186003036 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 474186003037 ATP binding site [chemical binding]; other site 474186003038 Mg2+ binding site [ion binding]; other site 474186003039 G-X-G motif; other site 474186003040 YycH protein; Region: YycH; pfam07435 474186003041 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863 474186003042 YycH protein; Region: YycI; pfam09648 474186003043 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 474186003044 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 474186003045 Predicted permeases [General function prediction only]; Region: COG0701 474186003046 Domain of unknown function (DUF1980); Region: DUF1980; cl01492 474186003047 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 474186003048 Uncharacterized conserved protein [Function unknown]; Region: COG2966 474186003049 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 474186003050 hypothetical protein; Provisional; Region: PRK05473 474186003051 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 474186003052 hypothetical protein; Provisional; Region: PRK13678 474186003053 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 474186003054 non-specific DNA binding site [nucleotide binding]; other site 474186003055 salt bridge; other site 474186003056 sequence-specific DNA binding site [nucleotide binding]; other site 474186003057 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 474186003058 binding surface 474186003059 TPR motif; other site 474186003060 Tetratricopeptide repeat; Region: TPR_12; pfam13424 474186003061 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 474186003062 Malic enzyme, N-terminal domain; Region: malic; pfam00390 474186003063 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 474186003064 putative NAD(P) binding site [chemical binding]; other site 474186003065 2-hydroxycarboxylate transporter family; Region: 2HCT; pfam03390 474186003066 PAS domain S-box; Region: sensory_box; TIGR00229 474186003067 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 474186003068 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 474186003069 active site 474186003070 phosphorylation site [posttranslational modification] 474186003071 intermolecular recognition site; other site 474186003072 dimerization interface [polypeptide binding]; other site 474186003073 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 474186003074 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 474186003075 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 474186003076 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 474186003077 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 474186003078 acetolactate synthase; Reviewed; Region: PRK08617 474186003079 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 474186003080 PYR/PP interface [polypeptide binding]; other site 474186003081 dimer interface [polypeptide binding]; other site 474186003082 TPP binding site [chemical binding]; other site 474186003083 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 474186003084 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 474186003085 TPP-binding site [chemical binding]; other site 474186003086 dimer interface [polypeptide binding]; other site 474186003087 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306 474186003088 PQQ-like domain; Region: PQQ_2; pfam13360 474186003089 WxL domain surface cell wall-binding; Region: WxL; pfam13731 474186003090 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 474186003091 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 474186003092 dimer interface [polypeptide binding]; other site 474186003093 conserved gate region; other site 474186003094 putative PBP binding loops; other site 474186003095 ABC-ATPase subunit interface; other site 474186003096 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 474186003097 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 474186003098 dimer interface [polypeptide binding]; other site 474186003099 conserved gate region; other site 474186003100 putative PBP binding loops; other site 474186003101 ABC-ATPase subunit interface; other site 474186003102 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 474186003103 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 474186003104 Walker A/P-loop; other site 474186003105 ATP binding site [chemical binding]; other site 474186003106 Q-loop/lid; other site 474186003107 ABC transporter signature motif; other site 474186003108 Walker B; other site 474186003109 D-loop; other site 474186003110 H-loop/switch region; other site 474186003111 TOBE domain; Region: TOBE_2; pfam08402 474186003112 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 474186003113 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 474186003114 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 474186003115 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 474186003116 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 474186003117 active site 474186003118 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 474186003119 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 474186003120 N-ethylammeline chlorohydrolase; Provisional; Region: PRK09045 474186003121 active site 474186003122 putative substrate binding pocket [chemical binding]; other site 474186003123 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 474186003124 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 474186003125 non-specific DNA binding site [nucleotide binding]; other site 474186003126 salt bridge; other site 474186003127 sequence-specific DNA binding site [nucleotide binding]; other site 474186003128 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 474186003129 ApbE family; Region: ApbE; pfam02424 474186003130 Predicted flavoprotein [General function prediction only]; Region: COG0431 474186003131 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 474186003132 Predicted flavoprotein [General function prediction only]; Region: COG0431 474186003133 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 474186003134 PAS domain; Region: PAS_10; pfam13596 474186003135 Mga helix-turn-helix domain; Region: Mga; pfam05043 474186003136 DNA-binding domain found in transcription regulators in plants such as APETALA2 and EREBP (ethylene responsive element binding protein). In EREBPs the domain specifically binds to the 11bp GCC box of the ethylene response element (ERE), a promotor...; Region: AP2; cl00033 474186003137 DNA binding site [nucleotide binding] 474186003138 phosphodiesterase YaeI; Provisional; Region: PRK11340 474186003139 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 474186003140 putative active site [active] 474186003141 putative metal binding site [ion binding]; other site 474186003142 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 474186003143 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 474186003144 dimer interface [polypeptide binding]; other site 474186003145 conserved gate region; other site 474186003146 ABC-ATPase subunit interface; other site 474186003147 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 474186003148 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 474186003149 dimer interface [polypeptide binding]; other site 474186003150 conserved gate region; other site 474186003151 ABC-ATPase subunit interface; other site 474186003152 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 474186003153 Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448 474186003154 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 474186003155 Exonuclease-Endonuclease-Phosphatase domain; uncharacterized family 1; Region: EEP-1; cd09083 474186003156 putative catalytic site [active] 474186003157 putative metal binding site [ion binding]; other site 474186003158 putative phosphate binding site [ion binding]; other site 474186003159 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 474186003160 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 474186003161 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 474186003162 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 474186003163 Transcriptional regulators [Transcription]; Region: PurR; COG1609 474186003164 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 474186003165 DNA binding site [nucleotide binding] 474186003166 domain linker motif; other site 474186003167 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 474186003168 dimerization interface [polypeptide binding]; other site 474186003169 ligand binding site [chemical binding]; other site 474186003170 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 474186003171 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 474186003172 DNA-binding site [nucleotide binding]; DNA binding site 474186003173 UTRA domain; Region: UTRA; pfam07702 474186003174 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 474186003175 beta-galactosidase; Region: BGL; TIGR03356 474186003176 putative oxidoreductase; Provisional; Region: PRK10206 474186003177 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 474186003178 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 474186003179 Protein of unknown function (DUF441); Region: DUF441; pfam04284 474186003180 glycoprotein BALF4; Provisional; Region: PHA03231 474186003181 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 474186003182 Domain of unknown function (DUF814); Region: DUF814; pfam05670 474186003183 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 474186003184 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 474186003185 zinc binding site [ion binding]; other site 474186003186 putative ligand binding site [chemical binding]; other site 474186003187 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 474186003188 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 474186003189 TM-ABC transporter signature motif; other site 474186003190 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 474186003191 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 474186003192 Walker A/P-loop; other site 474186003193 ATP binding site [chemical binding]; other site 474186003194 Q-loop/lid; other site 474186003195 ABC transporter signature motif; other site 474186003196 Walker B; other site 474186003197 D-loop; other site 474186003198 H-loop/switch region; other site 474186003199 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 474186003200 Uncharacterized conserved protein [Function unknown]; Region: COG2966 474186003201 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 474186003202 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 474186003203 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 474186003204 active site 474186003205 motif I; other site 474186003206 motif II; other site 474186003207 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 474186003208 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 474186003209 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 474186003210 active site 474186003211 phosphorylation site [posttranslational modification] 474186003212 intermolecular recognition site; other site 474186003213 dimerization interface [polypeptide binding]; other site 474186003214 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 474186003215 DNA binding site [nucleotide binding] 474186003216 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 474186003217 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 474186003218 dimerization interface [polypeptide binding]; other site 474186003219 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 474186003220 dimer interface [polypeptide binding]; other site 474186003221 phosphorylation site [posttranslational modification] 474186003222 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 474186003223 ATP binding site [chemical binding]; other site 474186003224 G-X-G motif; other site 474186003225 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 474186003226 Q-loop/lid; other site 474186003227 ABC transporter signature motif; other site 474186003228 Walker B; other site 474186003229 D-loop; other site 474186003230 H-loop/switch region; other site 474186003231 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 474186003232 Sulfatase; Region: Sulfatase; pfam00884 474186003233 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 474186003234 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 474186003235 putative RNA binding site [nucleotide binding]; other site 474186003236 ribonuclease HIII; Provisional; Region: PRK00996 474186003237 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 474186003238 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 474186003239 RNA/DNA hybrid binding site [nucleotide binding]; other site 474186003240 active site 474186003241 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 474186003242 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 474186003243 Collagen binding domain; Region: Collagen_bind; pfam05737 474186003244 Cna protein B-type domain; Region: Cna_B; pfam05738 474186003245 streptococcal pilin isopeptide linkage domain; Region: strep_pil_rpt; TIGR03786 474186003246 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 474186003247 ribosome maturation protein RimP; Reviewed; Region: PRK00092 474186003248 Sm and related proteins; Region: Sm_like; cl00259 474186003249 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 474186003250 putative oligomer interface [polypeptide binding]; other site 474186003251 putative RNA binding site [nucleotide binding]; other site 474186003252 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 474186003253 NusA N-terminal domain; Region: NusA_N; pfam08529 474186003254 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 474186003255 RNA binding site [nucleotide binding]; other site 474186003256 homodimer interface [polypeptide binding]; other site 474186003257 NusA-like KH domain; Region: KH_5; pfam13184 474186003258 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 474186003259 G-X-X-G motif; other site 474186003260 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 474186003261 putative RNA binding cleft [nucleotide binding]; other site 474186003262 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 474186003263 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 474186003264 translation initiation factor IF-2; Region: IF-2; TIGR00487 474186003265 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 474186003266 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 474186003267 G1 box; other site 474186003268 putative GEF interaction site [polypeptide binding]; other site 474186003269 GTP/Mg2+ binding site [chemical binding]; other site 474186003270 Switch I region; other site 474186003271 G2 box; other site 474186003272 G3 box; other site 474186003273 Switch II region; other site 474186003274 G4 box; other site 474186003275 G5 box; other site 474186003276 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 474186003277 Translation-initiation factor 2; Region: IF-2; pfam11987 474186003278 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 474186003279 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 474186003280 Domain of unknown function (DUF955); Region: DUF955; pfam06114 474186003281 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 474186003282 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 474186003283 non-specific DNA binding site [nucleotide binding]; other site 474186003284 salt bridge; other site 474186003285 sequence-specific DNA binding site [nucleotide binding]; other site 474186003286 DnaD and phage-associated domain; Region: DnaD_dom; TIGR01446 474186003287 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 474186003288 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 474186003289 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 474186003290 Walker A motif; other site 474186003291 Walker A motif; other site 474186003292 ATP binding site [chemical binding]; other site 474186003293 ATP binding site [chemical binding]; other site 474186003294 Walker B motif; other site 474186003295 phage transcriptional activator, RinA family; Region: phage_rinA; TIGR01636 474186003296 Phage major tail protein 2; Region: Phage_tail_2; cl11463 474186003297 Phage protein; Region: DUF3647; pfam12363 474186003298 Phage-related protein [Function unknown]; Region: COG5412 474186003299 Phage tail protein; Region: Sipho_tail; pfam05709 474186003300 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 474186003301 Holin family; Region: Phage_holin_4; pfam05105 474186003302 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 474186003303 amidase catalytic site [active] 474186003304 Zn binding residues [ion binding]; other site 474186003305 substrate binding site [chemical binding]; other site 474186003306 Bacterial SH3 domain; Region: SH3_5; pfam08460 474186003307 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01550 474186003308 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 474186003309 RNA binding site [nucleotide binding]; other site 474186003310 active site 474186003311 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 474186003312 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 474186003313 active site 474186003314 Riboflavin kinase; Region: Flavokinase; smart00904 474186003315 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 474186003316 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 474186003317 Coenzyme A binding pocket [chemical binding]; other site 474186003318 Predicted transcriptional regulators [Transcription]; Region: COG1695 474186003319 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 474186003320 Protein of unknown function (DUF1048); Region: DUF1048; pfam06304 474186003321 Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; pfam09860 474186003322 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 474186003323 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 474186003324 Transcriptional regulator [Transcription]; Region: LysR; COG0583 474186003325 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 474186003326 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 474186003327 dimerization interface [polypeptide binding]; other site 474186003328 Transcriptional regulator [Transcription]; Region: LysR; COG0583 474186003329 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 474186003330 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 474186003331 dimerization interface [polypeptide binding]; other site 474186003332 ykoK leader; OG1RF_nc10017 474186003333 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 474186003334 magnesium-transporting ATPase; Provisional; Region: PRK15122 474186003335 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 474186003336 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 474186003337 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 474186003338 motif II; other site 474186003339 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 474186003340 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 474186003341 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 474186003342 FeS/SAM binding site; other site 474186003343 HemN C-terminal domain; Region: HemN_C; pfam06969 474186003344 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 474186003345 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 474186003346 GrpE; Region: GrpE; pfam01025 474186003347 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 474186003348 dimer interface [polypeptide binding]; other site 474186003349 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 474186003350 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 474186003351 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 474186003352 nucleotide binding site [chemical binding]; other site 474186003353 NEF interaction site [polypeptide binding]; other site 474186003354 SBD interface [polypeptide binding]; other site 474186003355 chaperone protein DnaJ; Provisional; Region: PRK14276 474186003356 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 474186003357 HSP70 interaction site [polypeptide binding]; other site 474186003358 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 474186003359 substrate binding site [polypeptide binding]; other site 474186003360 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 474186003361 Zn binding sites [ion binding]; other site 474186003362 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 474186003363 substrate binding site [polypeptide binding]; other site 474186003364 dimer interface [polypeptide binding]; other site 474186003365 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 474186003366 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 474186003367 active site 474186003368 metal binding site [ion binding]; metal-binding site 474186003369 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 474186003370 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 474186003371 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 474186003372 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 474186003373 RNA binding site [nucleotide binding]; other site 474186003374 hypothetical protein; Provisional; Region: PRK04351 474186003375 SprT homologues; Region: SprT; cl01182 474186003376 aminotransferase AlaT; Validated; Region: PRK09265 474186003377 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 474186003378 pyridoxal 5'-phosphate binding site [chemical binding]; other site 474186003379 homodimer interface [polypeptide binding]; other site 474186003380 catalytic residue [active] 474186003381 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 474186003382 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 474186003383 non-specific DNA binding site [nucleotide binding]; other site 474186003384 salt bridge; other site 474186003385 sequence-specific DNA binding site [nucleotide binding]; other site 474186003386 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 474186003387 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 474186003388 active site 474186003389 dimer interface [polypeptide binding]; other site 474186003390 nitrogenase reductase; Reviewed; Region: nifH; PRK13235 474186003391 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; cl17626 474186003392 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 474186003393 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 474186003394 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 474186003395 Walker A/P-loop; other site 474186003396 ATP binding site [chemical binding]; other site 474186003397 Q-loop/lid; other site 474186003398 ABC transporter signature motif; other site 474186003399 Walker B; other site 474186003400 D-loop; other site 474186003401 H-loop/switch region; other site 474186003402 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 474186003403 FtsX-like permease family; Region: FtsX; pfam02687 474186003404 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 474186003405 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 474186003406 FtsX-like permease family; Region: FtsX; pfam02687 474186003407 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 474186003408 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 474186003409 Protein of unknown function (DUF2969); Region: DUF2969; pfam11184 474186003410 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 474186003411 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 474186003412 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 474186003413 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 474186003414 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 474186003415 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 474186003416 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3580 474186003417 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 474186003418 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 474186003419 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 474186003420 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 474186003421 DNA-binding site [nucleotide binding]; DNA binding site 474186003422 UTRA domain; Region: UTRA; pfam07702 474186003423 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 474186003424 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 474186003425 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; cl17489 474186003426 WXG100 protein secretion system (Wss), protein YukC; Region: YukC; cl01868 474186003427 type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928 474186003428 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 474186003429 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 474186003430 Domain of unknown function (DUF4176); Region: DUF4176; pfam13780 474186003431 LXG domain of WXG superfamily; Region: LXG; pfam04740 474186003432 type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928 474186003433 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 474186003434 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 474186003435 Domain of unknown function (DUF4176); Region: DUF4176; cl01867 474186003436 LXG domain of WXG superfamily; Region: LXG; pfam04740 474186003437 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 474186003438 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 474186003439 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 474186003440 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 474186003441 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 474186003442 Walker A/P-loop; other site 474186003443 ATP binding site [chemical binding]; other site 474186003444 Q-loop/lid; other site 474186003445 ABC transporter signature motif; other site 474186003446 Walker B; other site 474186003447 D-loop; other site 474186003448 H-loop/switch region; other site 474186003449 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 474186003450 FtsX-like permease family; Region: FtsX; pfam02687 474186003451 MarR family; Region: MarR_2; pfam12802 474186003452 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 474186003453 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 474186003454 dimer interface [polypeptide binding]; other site 474186003455 conserved gate region; other site 474186003456 putative PBP binding loops; other site 474186003457 ABC-ATPase subunit interface; other site 474186003458 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 474186003459 dimer interface [polypeptide binding]; other site 474186003460 conserved gate region; other site 474186003461 ABC-ATPase subunit interface; other site 474186003462 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 474186003463 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 474186003464 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 474186003465 homodimer interface [polypeptide binding]; other site 474186003466 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 474186003467 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 474186003468 active site 474186003469 homodimer interface [polypeptide binding]; other site 474186003470 catalytic site [active] 474186003471 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 474186003472 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 474186003473 Ca binding site [ion binding]; other site 474186003474 active site 474186003475 catalytic site [active] 474186003476 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 474186003477 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 474186003478 Ca binding site [ion binding]; other site 474186003479 active site 474186003480 catalytic site [active] 474186003481 Protein of unknown function (DUF1211); Region: DUF1211; cl01421 474186003482 ykoK leader; OG1RF_nc10018 474186003483 magnesium-transporting ATPase; Provisional; Region: PRK15122 474186003484 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 474186003485 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 474186003486 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 474186003487 Soluble P-type ATPase [General function prediction only]; Region: COG4087 474186003488 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 474186003489 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 474186003490 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 474186003491 tetramer interface [polypeptide binding]; other site 474186003492 TPP-binding site [chemical binding]; other site 474186003493 heterodimer interface [polypeptide binding]; other site 474186003494 phosphorylation loop region [posttranslational modification] 474186003495 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 474186003496 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 474186003497 alpha subunit interface [polypeptide binding]; other site 474186003498 TPP binding site [chemical binding]; other site 474186003499 heterodimer interface [polypeptide binding]; other site 474186003500 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 474186003501 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 474186003502 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 474186003503 E3 interaction surface; other site 474186003504 lipoyl attachment site [posttranslational modification]; other site 474186003505 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 474186003506 E3 interaction surface; other site 474186003507 lipoyl attachment site [posttranslational modification]; other site 474186003508 e3 binding domain; Region: E3_binding; pfam02817 474186003509 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 474186003510 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 474186003511 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 474186003512 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 474186003513 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 474186003514 Sensory domain found in PocR; Region: PocR; pfam10114 474186003515 Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936 474186003516 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 474186003517 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 474186003518 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 474186003519 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 474186003520 dimer interface [polypeptide binding]; other site 474186003521 active site 474186003522 metal binding site [ion binding]; metal-binding site 474186003523 dihydroxyacetone kinase, phosphotransfer subunit; Region: dha_pts; TIGR02364 474186003524 dihydroxyacetone kinase, DhaK subunit; Region: dhaK1; TIGR02363 474186003525 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 474186003526 dihydroxyacetone kinase, phosphoprotein-dependent, L subunit; Region: dha_L_ycgS; TIGR02365 474186003527 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 474186003528 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835 474186003529 dimer interface [polypeptide binding]; other site 474186003530 active site 474186003531 putative acyltransferase; Provisional; Region: PRK05790 474186003532 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 474186003533 dimer interface [polypeptide binding]; other site 474186003534 active site 474186003535 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 474186003536 homodimer interface [polypeptide binding]; other site 474186003537 catalytic residues [active] 474186003538 NAD binding site [chemical binding]; other site 474186003539 substrate binding pocket [chemical binding]; other site 474186003540 flexible flap; other site 474186003541 Domain of unknown function DUF20; Region: UPF0118; pfam01594 474186003542 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 474186003543 Uncharacterized conserved protein [Function unknown]; Region: COG1434 474186003544 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 474186003545 putative active site [active] 474186003546 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 474186003547 DNA-binding site [nucleotide binding]; DNA binding site 474186003548 RNA-binding motif; other site 474186003549 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 474186003550 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 474186003551 non-specific DNA binding site [nucleotide binding]; other site 474186003552 salt bridge; other site 474186003553 sequence-specific DNA binding site [nucleotide binding]; other site 474186003554 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 474186003555 Major Facilitator Superfamily; Region: MFS_1; pfam07690 474186003556 putative substrate translocation pore; other site 474186003557 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 474186003558 putative substrate translocation pore; other site 474186003559 metal-dependent hydrolase; Provisional; Region: PRK00685 474186003560 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 474186003561 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 474186003562 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 474186003563 DNA-binding site [nucleotide binding]; DNA binding site 474186003564 DRTGG domain; Region: DRTGG; pfam07085 474186003565 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 474186003566 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 474186003567 active site 2 [active] 474186003568 active site 1 [active] 474186003569 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 474186003570 DHH family; Region: DHH; pfam01368 474186003571 DHHA1 domain; Region: DHHA1; pfam02272 474186003572 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 474186003573 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 474186003574 PhnA protein; Region: PhnA; pfam03831 474186003575 VanZ like family; Region: VanZ; cl01971 474186003576 RDD family; Region: RDD; pfam06271 474186003577 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 474186003578 DEAD-like helicases superfamily; Region: DEXDc; smart00487 474186003579 ATP binding site [chemical binding]; other site 474186003580 Mg++ binding site [ion binding]; other site 474186003581 motif III; other site 474186003582 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 474186003583 nucleotide binding region [chemical binding]; other site 474186003584 ATP-binding site [chemical binding]; other site 474186003585 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 474186003586 DNA binding site [nucleotide binding] 474186003587 T-box leader; OG1RF_nc10019 474186003588 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 474186003589 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 474186003590 motif 1; other site 474186003591 active site 474186003592 motif 2; other site 474186003593 motif 3; other site 474186003594 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 474186003595 DHHA1 domain; Region: DHHA1; pfam02272 474186003596 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 474186003597 Family of unknown function (DUF633); Region: DUF633; pfam04816 474186003598 Uncharacterized conserved protein [Function unknown]; Region: COG0327 474186003599 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 474186003600 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 474186003601 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 474186003602 Uncharacterized conserved protein [Function unknown]; Region: COG0327 474186003603 peptidase T; Region: peptidase-T; TIGR01882 474186003604 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 474186003605 metal binding site [ion binding]; metal-binding site 474186003606 dimer interface [polypeptide binding]; other site 474186003607 Protein of unknown function (DUF1294); Region: DUF1294; pfam06961 474186003608 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 474186003609 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 474186003610 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 474186003611 GTP binding site; other site 474186003612 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 474186003613 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 474186003614 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 474186003615 putative dimer interface [polypeptide binding]; other site 474186003616 [2Fe-2S] cluster binding site [ion binding]; other site 474186003617 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 474186003618 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 474186003619 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 474186003620 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 474186003621 catalytic loop [active] 474186003622 iron binding site [ion binding]; other site 474186003623 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 474186003624 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 474186003625 [4Fe-4S] binding site [ion binding]; other site 474186003626 molybdopterin cofactor binding site; other site 474186003627 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790 474186003628 molybdopterin cofactor binding site; other site 474186003629 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 474186003630 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 474186003631 dimer interface [polypeptide binding]; other site 474186003632 putative functional site; other site 474186003633 putative MPT binding site; other site 474186003634 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 474186003635 trimer interface [polypeptide binding]; other site 474186003636 dimer interface [polypeptide binding]; other site 474186003637 putative active site [active] 474186003638 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 474186003639 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 474186003640 FeS/SAM binding site; other site 474186003641 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 474186003642 MOSC domain; Region: MOSC; pfam03473 474186003643 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 474186003644 MPT binding site; other site 474186003645 trimer interface [polypeptide binding]; other site 474186003646 MoeA_like. This domain is similar to a domain found in a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. There this domain is presumed to bind molybdopterin. The exact function of this subgroup is...; Region: MoeA_like; cd03522 474186003647 putative MPT binding site; other site 474186003648 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 474186003649 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 474186003650 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 474186003651 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 474186003652 putative PBP binding loops; other site 474186003653 ABC-ATPase subunit interface; other site 474186003654 ATP-binding cassette domain of the molybdenum transport system; Region: ABC_ModC_molybdenum_transporter; cd03297 474186003655 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 474186003656 Walker A/P-loop; other site 474186003657 ATP binding site [chemical binding]; other site 474186003658 Q-loop/lid; other site 474186003659 ABC transporter signature motif; other site 474186003660 Walker B; other site 474186003661 D-loop; other site 474186003662 H-loop/switch region; other site 474186003663 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 474186003664 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 474186003665 metal-binding site [ion binding] 474186003666 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 474186003667 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 474186003668 Cell division protein ZapA; Region: ZapA; cl01146 474186003669 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 474186003670 Colicin V production protein; Region: Colicin_V; pfam02674 474186003671 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 474186003672 MutS domain III; Region: MutS_III; pfam05192 474186003673 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 474186003674 Walker A/P-loop; other site 474186003675 ATP binding site [chemical binding]; other site 474186003676 Q-loop/lid; other site 474186003677 ABC transporter signature motif; other site 474186003678 Walker B; other site 474186003679 D-loop; other site 474186003680 H-loop/switch region; other site 474186003681 Smr domain; Region: Smr; pfam01713 474186003682 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 474186003683 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 474186003684 catalytic residues [active] 474186003685 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 474186003686 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 474186003687 GIY-YIG motif/motif A; other site 474186003688 active site 474186003689 catalytic site [active] 474186003690 putative DNA binding site [nucleotide binding]; other site 474186003691 metal binding site [ion binding]; metal-binding site 474186003692 UvrB/uvrC motif; Region: UVR; pfam02151 474186003693 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 474186003694 Protein of unknown function (DUF3884); Region: DUF3884; pfam13024 474186003695 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 474186003696 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 474186003697 Walker A/P-loop; other site 474186003698 ATP binding site [chemical binding]; other site 474186003699 Q-loop/lid; other site 474186003700 ABC transporter signature motif; other site 474186003701 Walker B; other site 474186003702 D-loop; other site 474186003703 H-loop/switch region; other site 474186003704 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 474186003705 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 474186003706 Transcriptional regulators [Transcription]; Region: PurR; COG1609 474186003707 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 474186003708 DNA binding site [nucleotide binding] 474186003709 domain linker motif; other site 474186003710 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 474186003711 putative dimerization interface [polypeptide binding]; other site 474186003712 putative ligand binding site [chemical binding]; other site 474186003713 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 474186003714 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 474186003715 NAD binding site [chemical binding]; other site 474186003716 sugar binding site [chemical binding]; other site 474186003717 divalent metal binding site [ion binding]; other site 474186003718 tetramer (dimer of dimers) interface [polypeptide binding]; other site 474186003719 dimer interface [polypeptide binding]; other site 474186003720 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 474186003721 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 474186003722 ABC transporter; Region: ABC_tran_2; pfam12848 474186003723 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 474186003724 HI0933-like protein; Region: HI0933_like; pfam03486 474186003725 glutamate dehydrogenase; Provisional; Region: PRK09414 474186003726 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 474186003727 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 474186003728 NAD(P) binding site [chemical binding]; other site 474186003729 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 474186003730 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 474186003731 active site 474186003732 dimer interface [polypeptide binding]; other site 474186003733 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 474186003734 dimer interface [polypeptide binding]; other site 474186003735 active site 474186003736 flavoprotein NrdI; Provisional; Region: PRK02551 474186003737 V-type ATP synthase subunit I; Validated; Region: PRK05771 474186003738 V-type ATP synthase subunit K; Validated; Region: PRK06558 474186003739 ATP synthase subunit C; Region: ATP-synt_C; pfam00137 474186003740 ATP synthase subunit C; Region: ATP-synt_C; pfam00137 474186003741 phosphodiesterase; Provisional; Region: PRK12704 474186003742 Archaeal/vacuolar-type H+-ATPase subunit C [Energy production and conversion]; Region: NtpC; COG1527 474186003743 V-type ATP synthase subunit C; Provisional; Region: PRK01198; cl00660 474186003744 V-type ATP synthase subunit F; Provisional; Region: PRK01395 474186003745 V-type ATP synthase subunit A; Provisional; Region: PRK04192 474186003746 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 474186003747 V/A-type ATP synthase catalytic subunit A. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_A; cd01134 474186003748 Walker A motif/ATP binding site; other site 474186003749 Walker B motif; other site 474186003750 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 474186003751 V-type ATP synthase subunit B; Provisional; Region: PRK04196 474186003752 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 474186003753 V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_B; cd01135 474186003754 Walker A motif homologous position; other site 474186003755 Walker B motif; other site 474186003756 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 474186003757 V-type ATP synthase subunit D; Reviewed; Region: PRK00373 474186003758 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 474186003759 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 474186003760 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 474186003761 DNA binding residues [nucleotide binding] 474186003762 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 474186003763 Firmicute fructose-1,6-bisphosphatase; Region: FBPase_2; pfam06874 474186003764 diaminopimelate decarboxylase; Region: lysA; TIGR01048 474186003765 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 474186003766 active site 474186003767 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 474186003768 substrate binding site [chemical binding]; other site 474186003769 catalytic residues [active] 474186003770 dimer interface [polypeptide binding]; other site 474186003771 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 474186003772 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 474186003773 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 474186003774 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 474186003775 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 474186003776 active site 474186003777 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 474186003778 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 474186003779 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 474186003780 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 474186003781 peptide binding site [polypeptide binding]; other site 474186003782 transcriptional antiterminator BglG; Provisional; Region: PRK09772 474186003783 CAT RNA binding domain; Region: CAT_RBD; smart01061 474186003784 PRD domain; Region: PRD; pfam00874 474186003785 PRD domain; Region: PRD; pfam00874 474186003786 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 474186003787 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 474186003788 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 474186003789 active site turn [active] 474186003790 phosphorylation site [posttranslational modification] 474186003791 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 474186003792 HPr interaction site; other site 474186003793 glycerol kinase (GK) interaction site [polypeptide binding]; other site 474186003794 active site 474186003795 phosphorylation site [posttranslational modification] 474186003796 HTH domain; Region: HTH_11; cl17392 474186003797 PRD domain; Region: PRD; pfam00874 474186003798 PRD domain; Region: PRD; pfam00874 474186003799 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 474186003800 active site 474186003801 P-loop; other site 474186003802 phosphorylation site [posttranslational modification] 474186003803 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 474186003804 active site 474186003805 phosphorylation site [posttranslational modification] 474186003806 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 474186003807 active site 474186003808 P-loop; other site 474186003809 phosphorylation site [posttranslational modification] 474186003810 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 474186003811 active site 474186003812 phosphorylation site [posttranslational modification] 474186003813 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 474186003814 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 474186003815 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 474186003816 substrate binding site [chemical binding]; other site 474186003817 hexamer interface [polypeptide binding]; other site 474186003818 metal binding site [ion binding]; metal-binding site 474186003819 Lysozyme-like; Region: Lysozyme_like; pfam13702 474186003820 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 474186003821 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 474186003822 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 474186003823 motif II; other site 474186003824 DNA primase, catalytic core; Region: dnaG; TIGR01391 474186003825 CHC2 zinc finger; Region: zf-CHC2; pfam01807 474186003826 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 474186003827 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 474186003828 active site 474186003829 metal binding site [ion binding]; metal-binding site 474186003830 interdomain interaction site; other site 474186003831 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 474186003832 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 474186003833 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 474186003834 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 474186003835 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 474186003836 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 474186003837 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 474186003838 DNA binding residues [nucleotide binding] 474186003839 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 474186003840 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 474186003841 S1 domain; Region: S1_2; pfam13509 474186003842 ferric uptake regulator; Provisional; Region: fur; PRK09462 474186003843 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 474186003844 metal binding site 2 [ion binding]; metal-binding site 474186003845 putative DNA binding helix; other site 474186003846 metal binding site 1 [ion binding]; metal-binding site 474186003847 dimer interface [polypeptide binding]; other site 474186003848 structural Zn2+ binding site [ion binding]; other site 474186003849 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 474186003850 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 474186003851 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 474186003852 GTPase CgtA; Reviewed; Region: obgE; PRK12297 474186003853 GTP1/OBG; Region: GTP1_OBG; pfam01018 474186003854 Obg GTPase; Region: Obg; cd01898 474186003855 G1 box; other site 474186003856 GTP/Mg2+ binding site [chemical binding]; other site 474186003857 Switch I region; other site 474186003858 G2 box; other site 474186003859 G3 box; other site 474186003860 Switch II region; other site 474186003861 G4 box; other site 474186003862 G5 box; other site 474186003863 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 474186003864 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 474186003865 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 474186003866 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 474186003867 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 474186003868 WHG domain; Region: WHG; pfam13305 474186003869 Protein of unknown function (DUF1093); Region: DUF1093; cl02185 474186003870 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 474186003871 active site 474186003872 Uncharacterized conserved protein [Function unknown]; Region: COG3589 474186003873 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 474186003874 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 474186003875 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 474186003876 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 474186003877 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 474186003878 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 474186003879 active site 474186003880 Int/Topo IB signature motif; other site 474186003881 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 474186003882 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 474186003883 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 474186003884 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 474186003885 RNA binding surface [nucleotide binding]; other site 474186003886 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 474186003887 active site 474186003888 Predicted membrane protein [Function unknown]; Region: COG3601 474186003889 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 474186003890 Predicted membrane protein [Function unknown]; Region: COG4640 474186003891 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 474186003892 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 474186003893 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 474186003894 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 474186003895 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 474186003896 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 474186003897 ATP binding site [chemical binding]; other site 474186003898 putative Mg++ binding site [ion binding]; other site 474186003899 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 474186003900 nucleotide binding region [chemical binding]; other site 474186003901 ATP-binding site [chemical binding]; other site 474186003902 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 474186003903 cytidylate kinase; Provisional; Region: cmk; PRK00023 474186003904 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 474186003905 CMP-binding site; other site 474186003906 The sites determining sugar specificity; other site 474186003907 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 474186003908 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 474186003909 RNA binding site [nucleotide binding]; other site 474186003910 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 474186003911 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 474186003912 RNA binding site [nucleotide binding]; other site 474186003913 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 474186003914 RNA binding site [nucleotide binding]; other site 474186003915 GTP-binding protein Der; Reviewed; Region: PRK00093 474186003916 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 474186003917 G1 box; other site 474186003918 GTP/Mg2+ binding site [chemical binding]; other site 474186003919 Switch I region; other site 474186003920 G2 box; other site 474186003921 Switch II region; other site 474186003922 G3 box; other site 474186003923 G4 box; other site 474186003924 G5 box; other site 474186003925 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 474186003926 G1 box; other site 474186003927 GTP/Mg2+ binding site [chemical binding]; other site 474186003928 Switch I region; other site 474186003929 G2 box; other site 474186003930 G3 box; other site 474186003931 Switch II region; other site 474186003932 G4 box; other site 474186003933 G5 box; other site 474186003934 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 474186003935 IHF dimer interface [polypeptide binding]; other site 474186003936 IHF - DNA interface [nucleotide binding]; other site 474186003937 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 474186003938 TPR motif; other site 474186003939 binding surface 474186003940 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 474186003941 binding surface 474186003942 TPR motif; other site 474186003943 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 474186003944 TPR motif; other site 474186003945 binding surface 474186003946 hypothetical protein; Provisional; Region: PRK03636 474186003947 UPF0302 domain; Region: UPF0302; pfam08864 474186003948 A short protein domain of unknown function; Region: IDEAL; smart00914 474186003949 Uncharacterized conserved protein [Function unknown]; Region: COG1284 474186003950 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 474186003951 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 474186003952 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531 474186003953 homodimer interface [polypeptide binding]; other site 474186003954 metal binding site [ion binding]; metal-binding site 474186003955 dihydrodipicolinate reductase; Provisional; Region: PRK00048 474186003956 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 474186003957 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 474186003958 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 474186003959 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 474186003960 active site 474186003961 NTP binding site [chemical binding]; other site 474186003962 metal binding triad [ion binding]; metal-binding site 474186003963 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 474186003964 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 474186003965 Predicted thioesterase [General function prediction only]; Region: COG5496 474186003966 shikimate 5-dehydrogenase; Provisional; Region: PRK12548 474186003967 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 474186003968 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 474186003969 shikimate binding site; other site 474186003970 NAD(P) binding site [chemical binding]; other site 474186003971 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 474186003972 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 474186003973 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 474186003974 active site 474186003975 dimer interface [polypeptide binding]; other site 474186003976 metal binding site [ion binding]; metal-binding site 474186003977 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 474186003978 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 474186003979 Tetramer interface [polypeptide binding]; other site 474186003980 active site 474186003981 FMN-binding site [chemical binding]; other site 474186003982 prephenate dehydrogenase; Validated; Region: PRK06545 474186003983 prephenate dehydrogenase; Validated; Region: PRK08507 474186003984 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 474186003985 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 474186003986 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 474186003987 hinge; other site 474186003988 active site 474186003989 shikimate kinase; Reviewed; Region: aroK; PRK00131 474186003990 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 474186003991 ADP binding site [chemical binding]; other site 474186003992 magnesium binding site [ion binding]; other site 474186003993 putative shikimate binding site; other site 474186003994 prephenate dehydratase; Provisional; Region: PRK11898 474186003995 Prephenate dehydratase; Region: PDT; pfam00800 474186003996 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 474186003997 putative L-Phe binding site [chemical binding]; other site 474186003998 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816 474186003999 EDD domain protein, DegV family; Region: DegV; TIGR00762 474186004000 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 474186004001 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 474186004002 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 474186004003 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 474186004004 Walker A/P-loop; other site 474186004005 ATP binding site [chemical binding]; other site 474186004006 Q-loop/lid; other site 474186004007 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 474186004008 ABC transporter signature motif; other site 474186004009 Walker B; other site 474186004010 D-loop; other site 474186004011 ABC transporter; Region: ABC_tran_2; pfam12848 474186004012 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 474186004013 thymidylate synthase; Region: thym_sym; TIGR03284 474186004014 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 474186004015 dimerization interface [polypeptide binding]; other site 474186004016 active site 474186004017 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 474186004018 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 474186004019 folate binding site [chemical binding]; other site 474186004020 NADP+ binding site [chemical binding]; other site 474186004021 epoxyqueuosine reductase; Region: TIGR00276 474186004022 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 474186004023 HEAT repeat; Region: HEAT; pfam02985 474186004024 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 474186004025 putative DNA binding site [nucleotide binding]; other site 474186004026 LexA repressor; Validated; Region: PRK00215 474186004027 putative Zn2+ binding site [ion binding]; other site 474186004028 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 474186004029 Catalytic site [active] 474186004030 hypothetical protein; Provisional; Region: PRK02539 474186004031 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 474186004032 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 474186004033 TPP-binding site [chemical binding]; other site 474186004034 dimer interface [polypeptide binding]; other site 474186004035 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 474186004036 PYR/PP interface [polypeptide binding]; other site 474186004037 dimer interface [polypeptide binding]; other site 474186004038 TPP binding site [chemical binding]; other site 474186004039 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 474186004040 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 474186004041 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 474186004042 putative substrate translocation pore; other site 474186004043 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 474186004044 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 474186004045 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 474186004046 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 474186004047 dimer interface [polypeptide binding]; other site 474186004048 pyridoxal 5'-phosphate binding site [chemical binding]; other site 474186004049 catalytic residue [active] 474186004050 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 474186004051 metal binding site 2 [ion binding]; metal-binding site 474186004052 putative DNA binding helix; other site 474186004053 metal binding site 1 [ion binding]; metal-binding site 474186004054 dimer interface [polypeptide binding]; other site 474186004055 structural Zn2+ binding site [ion binding]; other site 474186004056 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 474186004057 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 474186004058 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 474186004059 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 474186004060 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 474186004061 nudix motif; other site 474186004062 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 474186004063 Coenzyme A binding pocket [chemical binding]; other site 474186004064 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 474186004065 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 474186004066 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 474186004067 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 474186004068 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 474186004069 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 474186004070 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 474186004071 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 474186004072 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 474186004073 Walker A/P-loop; other site 474186004074 ATP binding site [chemical binding]; other site 474186004075 Q-loop/lid; other site 474186004076 ABC transporter signature motif; other site 474186004077 Walker B; other site 474186004078 D-loop; other site 474186004079 H-loop/switch region; other site 474186004080 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 474186004081 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 474186004082 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 474186004083 Walker A/P-loop; other site 474186004084 ATP binding site [chemical binding]; other site 474186004085 Q-loop/lid; other site 474186004086 ABC transporter signature motif; other site 474186004087 Walker B; other site 474186004088 D-loop; other site 474186004089 H-loop/switch region; other site 474186004090 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 474186004091 nudix motif; other site 474186004092 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 474186004093 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 474186004094 tetramer interface [polypeptide binding]; other site 474186004095 heme binding pocket [chemical binding]; other site 474186004096 NADPH binding site [chemical binding]; other site 474186004097 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 474186004098 DNA photolyase; Region: DNA_photolyase; pfam00875 474186004099 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 474186004100 non-specific DNA binding site [nucleotide binding]; other site 474186004101 salt bridge; other site 474186004102 sequence-specific DNA binding site [nucleotide binding]; other site 474186004103 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 474186004104 binding surface 474186004105 TPR motif; other site 474186004106 Tetratricopeptide repeat; Region: TPR_12; pfam13424 474186004107 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 474186004108 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 474186004109 active site turn [active] 474186004110 phosphorylation site [posttranslational modification] 474186004111 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 474186004112 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 474186004113 HPr interaction site; other site 474186004114 glycerol kinase (GK) interaction site [polypeptide binding]; other site 474186004115 active site 474186004116 phosphorylation site [posttranslational modification] 474186004117 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 474186004118 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 474186004119 Ca binding site [ion binding]; other site 474186004120 active site 474186004121 catalytic site [active] 474186004122 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 474186004123 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 474186004124 substrate binding [chemical binding]; other site 474186004125 active site 474186004126 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 474186004127 Transcriptional regulators [Transcription]; Region: PurR; COG1609 474186004128 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 474186004129 DNA binding site [nucleotide binding] 474186004130 domain linker motif; other site 474186004131 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 474186004132 dimerization interface [polypeptide binding]; other site 474186004133 ligand binding site [chemical binding]; other site 474186004134 sodium binding site [ion binding]; other site 474186004135 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 474186004136 beta-galactosidase; Region: BGL; TIGR03356 474186004137 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 474186004138 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 474186004139 active site turn [active] 474186004140 phosphorylation site [posttranslational modification] 474186004141 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 474186004142 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 474186004143 HPr interaction site; other site 474186004144 glycerol kinase (GK) interaction site [polypeptide binding]; other site 474186004145 active site 474186004146 phosphorylation site [posttranslational modification] 474186004147 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 474186004148 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 474186004149 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 474186004150 putative active site [active] 474186004151 catalytic site [active] 474186004152 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 474186004153 putative active site [active] 474186004154 catalytic site [active] 474186004155 hypothetical protein; Provisional; Region: PRK04164 474186004156 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 474186004157 Domain of unknown function (DUF1803); Region: DUF1803; pfam08820 474186004158 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 474186004159 DHH family; Region: DHH; pfam01368 474186004160 DHHA2 domain; Region: DHHA2; pfam02833 474186004161 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 474186004162 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 474186004163 FeS/SAM binding site; other site 474186004164 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 474186004165 Pyruvate formate lyase 1; Region: PFL1; cd01678 474186004166 coenzyme A binding site [chemical binding]; other site 474186004167 active site 474186004168 catalytic residues [active] 474186004169 glycine loop; other site 474186004170 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 474186004171 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 474186004172 CAP-like domain; other site 474186004173 active site 474186004174 primary dimer interface [polypeptide binding]; other site 474186004175 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 474186004176 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 474186004177 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 474186004178 ATP binding site [chemical binding]; other site 474186004179 Mg2+ binding site [ion binding]; other site 474186004180 G-X-G motif; other site 474186004181 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 474186004182 anchoring element; other site 474186004183 dimer interface [polypeptide binding]; other site 474186004184 ATP binding site [chemical binding]; other site 474186004185 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 474186004186 active site 474186004187 putative metal-binding site [ion binding]; other site 474186004188 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 474186004189 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 474186004190 Ethanolamine utilisation protein EutQ; Region: EutQ; pfam06249 474186004191 ethanolamine utilization protein EutQ; Provisional; Region: PRK15457 474186004192 ethanolamine utilization protein EutH; Provisional; Region: PRK15086 474186004193 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 474186004194 Hexamer/Pentamer interface [polypeptide binding]; other site 474186004195 central pore; other site 474186004196 ethanolamine utilization protein; Region: eut_hyp; TIGR02536 474186004197 propanediol utilization phosphotransacylase; Provisional; Region: PRK15070 474186004198 Propanediol utilisation protein PduL; Region: PduL; pfam06130 474186004199 Propanediol utilisation protein PduL; Region: PduL; pfam06130 474186004200 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; cl00920 474186004201 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 474186004202 1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059 474186004203 Hexamer interface [polypeptide binding]; other site 474186004204 Putative hexagonal pore residue; other site 474186004205 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 474186004206 putative catalytic cysteine [active] 474186004207 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 474186004208 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 474186004209 Hexamer interface [polypeptide binding]; other site 474186004210 Hexagonal pore residue; other site 474186004211 ethanolamine utilization protein EutL; Provisional; Region: PRK15405 474186004212 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_EutL_repeat1; cd07049 474186004213 putative hexamer interface [polypeptide binding]; other site 474186004214 putative hexagonal pore; other site 474186004215 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_EutL_repeat2; cd07050 474186004216 putative hexamer interface [polypeptide binding]; other site 474186004217 putative hexagonal pore; other site 474186004218 Ethanolamine ammonia-lyase, small subunit [Amino acid transport and metabolism]; Region: EutC; COG4302 474186004219 ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067 474186004220 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 474186004221 reactivating factor for ethanolamine ammonia lyase; Provisional; Region: eutA; PRK10719 474186004222 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 474186004223 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 474186004224 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 474186004225 Histidine kinase; Region: HisKA_2; pfam07568 474186004226 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 474186004227 ATP binding site [chemical binding]; other site 474186004228 Mg2+ binding site [ion binding]; other site 474186004229 G-X-G motif; other site 474186004230 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 474186004231 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 474186004232 active site 474186004233 phosphorylation site [posttranslational modification] 474186004234 intermolecular recognition site; other site 474186004235 dimerization interface [polypeptide binding]; other site 474186004236 ANTAR domain; Region: ANTAR; pfam03861 474186004237 1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046 474186004238 putative hexamer interface [polypeptide binding]; other site 474186004239 putative hexagonal pore; other site 474186004240 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 474186004241 1,3-propanediol dehydrogenase (PPD) catalyzes the reduction of 3-hydroxypropionaldehyde (3-HPA) to 1,3-propanediol in glycerol metabolism; Region: PDD; cd08180 474186004242 putative active site [active] 474186004243 metal binding site [ion binding]; metal-binding site 474186004244 ATP:cob(I)alamin adenosyltransferase; Region: PduO_Nterm; TIGR00636 474186004245 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 474186004246 G1 box; other site 474186004247 GTP/Mg2+ binding site [chemical binding]; other site 474186004248 G2 box; other site 474186004249 Switch I region; other site 474186004250 G3 box; other site 474186004251 Switch II region; other site 474186004252 G4 box; other site 474186004253 G5 box; other site 474186004254 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 474186004255 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 474186004256 Walker A/P-loop; other site 474186004257 ATP binding site [chemical binding]; other site 474186004258 Q-loop/lid; other site 474186004259 ABC transporter signature motif; other site 474186004260 Walker B; other site 474186004261 D-loop; other site 474186004262 H-loop/switch region; other site 474186004263 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 474186004264 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 474186004265 ABC-ATPase subunit interface; other site 474186004266 dimer interface [polypeptide binding]; other site 474186004267 putative PBP binding regions; other site 474186004268 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 474186004269 Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143 474186004270 putative binding site residues; other site 474186004271 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 474186004272 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 474186004273 active site 474186004274 catalytic residues [active] 474186004275 CodY GAF-like domain; Region: CodY; pfam06018 474186004276 GTP-sensing transcriptional pleiotropic repressor CodY; Region: codY_Gpos; TIGR02787 474186004277 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 474186004278 putative DNA binding site [nucleotide binding]; other site 474186004279 putative Zn2+ binding site [ion binding]; other site 474186004280 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 474186004281 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 474186004282 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 474186004283 Walker A motif; other site 474186004284 ATP binding site [chemical binding]; other site 474186004285 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 474186004286 Walker B motif; other site 474186004287 arginine finger; other site 474186004288 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 474186004289 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 474186004290 active site 474186004291 HslU subunit interaction site [polypeptide binding]; other site 474186004292 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 474186004293 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 474186004294 active site 474186004295 Int/Topo IB signature motif; other site 474186004296 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 474186004297 Glucose inhibited division protein A; Region: GIDA; pfam01134 474186004298 DNA topoisomerase I; Validated; Region: PRK05582 474186004299 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 474186004300 active site 474186004301 interdomain interaction site; other site 474186004302 putative metal-binding site [ion binding]; other site 474186004303 nucleotide binding site [chemical binding]; other site 474186004304 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 474186004305 domain I; other site 474186004306 DNA binding groove [nucleotide binding] 474186004307 phosphate binding site [ion binding]; other site 474186004308 domain II; other site 474186004309 domain III; other site 474186004310 nucleotide binding site [chemical binding]; other site 474186004311 catalytic site [active] 474186004312 domain IV; other site 474186004313 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 474186004314 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 474186004315 CAAX protease self-immunity; Region: Abi; pfam02517 474186004316 DNA protecting protein DprA; Region: dprA; TIGR00732 474186004317 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 474186004318 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 474186004319 RNA/DNA hybrid binding site [nucleotide binding]; other site 474186004320 active site 474186004321 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 474186004322 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 474186004323 GTP/Mg2+ binding site [chemical binding]; other site 474186004324 G4 box; other site 474186004325 G5 box; other site 474186004326 G1 box; other site 474186004327 Switch I region; other site 474186004328 G2 box; other site 474186004329 G3 box; other site 474186004330 Switch II region; other site 474186004331 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 474186004332 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 474186004333 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 474186004334 Transcriptional regulator [Transcription]; Region: LysR; COG0583 474186004335 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 474186004336 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 474186004337 dimerization interface [polypeptide binding]; other site 474186004338 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 474186004339 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 474186004340 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 474186004341 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 474186004342 E3 interaction surface; other site 474186004343 lipoyl attachment site [posttranslational modification]; other site 474186004344 e3 binding domain; Region: E3_binding; pfam02817 474186004345 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 474186004346 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 474186004347 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 474186004348 alpha subunit interface [polypeptide binding]; other site 474186004349 TPP binding site [chemical binding]; other site 474186004350 heterodimer interface [polypeptide binding]; other site 474186004351 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 474186004352 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 474186004353 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 474186004354 tetramer interface [polypeptide binding]; other site 474186004355 TPP-binding site [chemical binding]; other site 474186004356 heterodimer interface [polypeptide binding]; other site 474186004357 phosphorylation loop region [posttranslational modification] 474186004358 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 474186004359 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 474186004360 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 474186004361 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 474186004362 nucleotide binding site [chemical binding]; other site 474186004363 Acetokinase family; Region: Acetate_kinase; cl17229 474186004364 branched-chain phosphotransacylase; Region: branched_ptb; TIGR02709 474186004365 Uncharacterized conserved protein [Function unknown]; Region: COG1434 474186004366 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 474186004367 putative active site [active] 474186004368 TraX protein; Region: TraX; cl05434 474186004369 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 474186004370 classical (c) SDRs; Region: SDR_c; cd05233 474186004371 NAD(P) binding site [chemical binding]; other site 474186004372 active site 474186004373 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 474186004374 MarR family; Region: MarR; pfam01047 474186004375 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 474186004376 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 474186004377 Zn binding site [ion binding]; other site 474186004378 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 474186004379 Zn binding site [ion binding]; other site 474186004380 Predicted esterase [General function prediction only]; Region: COG0400 474186004381 putative hydrolase; Provisional; Region: PRK11460 474186004382 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 474186004383 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 474186004384 putative NAD(P) binding site [chemical binding]; other site 474186004385 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 474186004386 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 474186004387 FtsX-like permease family; Region: FtsX; pfam02687 474186004388 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 474186004389 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 474186004390 Walker A/P-loop; other site 474186004391 ATP binding site [chemical binding]; other site 474186004392 Q-loop/lid; other site 474186004393 ABC transporter signature motif; other site 474186004394 Walker B; other site 474186004395 D-loop; other site 474186004396 H-loop/switch region; other site 474186004397 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 474186004398 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 474186004399 Walker A/P-loop; other site 474186004400 ATP binding site [chemical binding]; other site 474186004401 Q-loop/lid; other site 474186004402 ABC transporter signature motif; other site 474186004403 Walker B; other site 474186004404 D-loop; other site 474186004405 H-loop/switch region; other site 474186004406 Predicted transcriptional regulators [Transcription]; Region: COG1725 474186004407 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 474186004408 DNA-binding site [nucleotide binding]; DNA binding site 474186004409 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 474186004410 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462 474186004411 Catalytic site [active] 474186004412 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 474186004413 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 474186004414 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 474186004415 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 474186004416 protein binding site [polypeptide binding]; other site 474186004417 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 474186004418 Catalytic dyad [active] 474186004419 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 474186004420 hypothetical protein; Provisional; Region: PRK13672 474186004421 methionine sulfoxide reductase A; Provisional; Region: PRK14054 474186004422 Uncharacterized protein conserved in bacteria (DUF2140); Region: DUF2140; pfam09911 474186004423 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 474186004424 active site 474186004425 catalytic triad [active] 474186004426 oxyanion hole [active] 474186004427 EDD domain protein, DegV family; Region: DegV; TIGR00762 474186004428 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 474186004429 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 474186004430 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 474186004431 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 474186004432 active site 474186004433 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 474186004434 DHH family; Region: DHH; pfam01368 474186004435 DHHA1 domain; Region: DHHA1; pfam02272 474186004436 Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; pfam10141 474186004437 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 474186004438 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 474186004439 NAD(P) binding site [chemical binding]; other site 474186004440 active site 474186004441 ribonuclease Z; Region: RNase_Z; TIGR02651 474186004442 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 474186004443 KH domain; Region: KH_4; pfam13083 474186004444 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 474186004445 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 474186004446 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 474186004447 Coenzyme A binding pocket [chemical binding]; other site 474186004448 Predicted flavoprotein [General function prediction only]; Region: COG0431 474186004449 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 474186004450 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 474186004451 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 474186004452 DNA binding residues [nucleotide binding] 474186004453 dimer interface [polypeptide binding]; other site 474186004454 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 474186004455 signal recognition particle protein; Provisional; Region: PRK10867 474186004456 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 474186004457 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 474186004458 P loop; other site 474186004459 GTP binding site [chemical binding]; other site 474186004460 Signal peptide binding domain; Region: SRP_SPB; pfam02978 474186004461 putative DNA-binding protein; Validated; Region: PRK00118 474186004462 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 474186004463 Uncharacterized conserved protein [Function unknown]; Region: COG1683 474186004464 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 474186004465 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 474186004466 active site 474186004467 phosphorylation site [posttranslational modification] 474186004468 intermolecular recognition site; other site 474186004469 dimerization interface [polypeptide binding]; other site 474186004470 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 474186004471 DNA binding site [nucleotide binding] 474186004472 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 474186004473 PAS domain; Region: PAS; smart00091 474186004474 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 474186004475 dimer interface [polypeptide binding]; other site 474186004476 phosphorylation site [posttranslational modification] 474186004477 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 474186004478 ATP binding site [chemical binding]; other site 474186004479 Mg2+ binding site [ion binding]; other site 474186004480 G-X-G motif; other site 474186004481 PBP superfamily domain; Region: PBP_like_2; cl17296 474186004482 aromatic amino acid aminotransferase; Validated; Region: PRK07309 474186004483 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 474186004484 pyridoxal 5'-phosphate binding site [chemical binding]; other site 474186004485 homodimer interface [polypeptide binding]; other site 474186004486 catalytic residue [active] 474186004487 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 474186004488 N-terminal catalytic domain of SPGH38, a putative alpha-mannosidase of Streptococcus pyogenes, and its prokaryotic homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_SpGH38_like; cd10814 474186004489 active site 474186004490 metal binding site [ion binding]; metal-binding site 474186004491 homodimer interface [polypeptide binding]; other site 474186004492 catalytic site [active] 474186004493 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 474186004494 Uncharacterized conserved protein [Function unknown]; Region: COG3538 474186004495 Protein of unknown function (DUF1237); Region: DUF1237; pfam06824 474186004496 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 474186004497 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 474186004498 DNA-binding site [nucleotide binding]; DNA binding site 474186004499 Transcriptional regulators [Transcription]; Region: PurR; COG1609 474186004500 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 474186004501 ligand binding site [chemical binding]; other site 474186004502 dimerization interface [polypeptide binding]; other site 474186004503 Transcriptional regulator [Transcription]; Region: LysR; COG0583 474186004504 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 474186004505 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 474186004506 dimerization interface [polypeptide binding]; other site 474186004507 Carbonic anhydrase [Inorganic ion transport and metabolism]; Region: Cah; COG3338 474186004508 Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124 474186004509 active site 474186004510 zinc binding site [ion binding]; other site 474186004511 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 474186004512 active site 474186004513 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 474186004514 active site 474186004515 dimer interface [polypeptide binding]; other site 474186004516 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 474186004517 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 474186004518 heterodimer interface [polypeptide binding]; other site 474186004519 active site 474186004520 FMN binding site [chemical binding]; other site 474186004521 homodimer interface [polypeptide binding]; other site 474186004522 substrate binding site [chemical binding]; other site 474186004523 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 474186004524 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 474186004525 FAD binding pocket [chemical binding]; other site 474186004526 FAD binding motif [chemical binding]; other site 474186004527 phosphate binding motif [ion binding]; other site 474186004528 beta-alpha-beta structure motif; other site 474186004529 NAD binding pocket [chemical binding]; other site 474186004530 Iron coordination center [ion binding]; other site 474186004531 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 474186004532 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 474186004533 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 474186004534 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 474186004535 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 474186004536 ATP-grasp domain; Region: ATP-grasp_4; cl17255 474186004537 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 474186004538 IMP binding site; other site 474186004539 dimer interface [polypeptide binding]; other site 474186004540 interdomain contacts; other site 474186004541 partial ornithine binding site; other site 474186004542 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 474186004543 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 474186004544 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 474186004545 catalytic site [active] 474186004546 subunit interface [polypeptide binding]; other site 474186004547 dihydroorotase; Validated; Region: pyrC; PRK09357 474186004548 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 474186004549 active site 474186004550 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 474186004551 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 474186004552 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 474186004553 uracil transporter; Provisional; Region: PRK10720 474186004554 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 474186004555 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 474186004556 active site 474186004557 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 474186004558 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 474186004559 RNA binding surface [nucleotide binding]; other site 474186004560 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 474186004561 active site 474186004562 lipoprotein signal peptidase; Provisional; Region: PRK14797 474186004563 lipoprotein signal peptidase; Provisional; Region: PRK14787 474186004564 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 474186004565 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 474186004566 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 474186004567 Potassium binding sites [ion binding]; other site 474186004568 Cesium cation binding sites [ion binding]; other site 474186004569 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 474186004570 DNA-binding site [nucleotide binding]; DNA binding site 474186004571 RNA-binding motif; other site 474186004572 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 474186004573 RNA/DNA hybrid binding site [nucleotide binding]; other site 474186004574 active site 474186004575 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 474186004576 putative deacylase active site [active] 474186004577 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 474186004578 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 474186004579 active site 474186004580 catalytic residue [active] 474186004581 dimer interface [polypeptide binding]; other site 474186004582 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 474186004583 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 474186004584 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 474186004585 Walker A/P-loop; other site 474186004586 ATP binding site [chemical binding]; other site 474186004587 Q-loop/lid; other site 474186004588 ABC transporter signature motif; other site 474186004589 Walker B; other site 474186004590 D-loop; other site 474186004591 H-loop/switch region; other site 474186004592 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 474186004593 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 474186004594 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 474186004595 Walker A/P-loop; other site 474186004596 ATP binding site [chemical binding]; other site 474186004597 Q-loop/lid; other site 474186004598 ABC transporter signature motif; other site 474186004599 Walker B; other site 474186004600 D-loop; other site 474186004601 H-loop/switch region; other site 474186004602 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3763 474186004603 endonuclease IV; Provisional; Region: PRK01060 474186004604 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 474186004605 AP (apurinic/apyrimidinic) site pocket; other site 474186004606 DNA interaction; other site 474186004607 Metal-binding active site; metal-binding site 474186004608 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 474186004609 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 474186004610 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 474186004611 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 474186004612 active site 474186004613 HIGH motif; other site 474186004614 dimer interface [polypeptide binding]; other site 474186004615 KMSKS motif; other site 474186004616 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 474186004617 RNA binding surface [nucleotide binding]; other site 474186004618 Transglycosylase; Region: Transgly; pfam00912 474186004619 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 474186004620 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 474186004621 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 474186004622 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 474186004623 Walker A/P-loop; other site 474186004624 ATP binding site [chemical binding]; other site 474186004625 Q-loop/lid; other site 474186004626 ABC transporter signature motif; other site 474186004627 Walker B; other site 474186004628 D-loop; other site 474186004629 H-loop/switch region; other site 474186004630 catabolite control protein A; Region: ccpA; TIGR01481 474186004631 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 474186004632 DNA binding site [nucleotide binding] 474186004633 domain linker motif; other site 474186004634 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 474186004635 dimerization interface [polypeptide binding]; other site 474186004636 effector binding site; other site 474186004637 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 474186004638 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 474186004639 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 474186004640 active site 474186004641 YtxH-like protein; Region: YtxH; pfam12732 474186004642 Bacterial protein of unknown function (DUF948); Region: DUF948; pfam06103 474186004643 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 474186004644 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 474186004645 active site 474186004646 tetramer interface; other site 474186004647 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 474186004648 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 474186004649 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 474186004650 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 474186004651 HPr kinase/phosphorylase; Provisional; Region: PRK05428 474186004652 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 474186004653 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 474186004654 Hpr binding site; other site 474186004655 active site 474186004656 homohexamer subunit interaction site [polypeptide binding]; other site 474186004657 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 474186004658 GIY-YIG motif/motif A; other site 474186004659 active site 474186004660 catalytic site [active] 474186004661 putative DNA binding site [nucleotide binding]; other site 474186004662 metal binding site [ion binding]; metal-binding site 474186004663 Membrane protein of unknown function; Region: DUF360; pfam04020 474186004664 PspC domain; Region: PspC; pfam04024 474186004665 Uncharacterized conserved protein [Function unknown]; Region: COG3595 474186004666 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 474186004667 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 474186004668 PhoU domain; Region: PhoU; pfam01895 474186004669 PhoU domain; Region: PhoU; pfam01895 474186004670 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14255 474186004671 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 474186004672 Walker A/P-loop; other site 474186004673 ATP binding site [chemical binding]; other site 474186004674 Q-loop/lid; other site 474186004675 ABC transporter signature motif; other site 474186004676 Walker B; other site 474186004677 D-loop; other site 474186004678 H-loop/switch region; other site 474186004679 phosphate transporter ATP-binding protein; Provisional; Region: PRK14237 474186004680 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 474186004681 Walker A/P-loop; other site 474186004682 ATP binding site [chemical binding]; other site 474186004683 Q-loop/lid; other site 474186004684 ABC transporter signature motif; other site 474186004685 Walker B; other site 474186004686 D-loop; other site 474186004687 H-loop/switch region; other site 474186004688 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 474186004689 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 474186004690 dimer interface [polypeptide binding]; other site 474186004691 conserved gate region; other site 474186004692 putative PBP binding loops; other site 474186004693 ABC-ATPase subunit interface; other site 474186004694 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 474186004695 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 474186004696 dimer interface [polypeptide binding]; other site 474186004697 conserved gate region; other site 474186004698 putative PBP binding loops; other site 474186004699 ABC-ATPase subunit interface; other site 474186004700 phosphate binding protein; Region: ptsS_2; TIGR02136 474186004701 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 474186004702 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 474186004703 FtsX-like permease family; Region: FtsX; pfam02687 474186004704 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 474186004705 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 474186004706 Walker A/P-loop; other site 474186004707 ATP binding site [chemical binding]; other site 474186004708 Q-loop/lid; other site 474186004709 ABC transporter signature motif; other site 474186004710 Walker B; other site 474186004711 D-loop; other site 474186004712 H-loop/switch region; other site 474186004713 peptide chain release factor 2; Provisional; Region: PRK06746 474186004714 RNA polymerase II transcription mediator complex subunit 9; Region: Med9; pfam07544 474186004715 This domain is found in peptide chain release factors; Region: PCRF; smart00937 474186004716 RF-1 domain; Region: RF-1; pfam00472 474186004717 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 474186004718 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 474186004719 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 474186004720 nucleotide binding region [chemical binding]; other site 474186004721 ATP-binding site [chemical binding]; other site 474186004722 SEC-C motif; Region: SEC-C; pfam02810 474186004723 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 474186004724 30S subunit binding site; other site 474186004725 comF family protein; Region: comF; TIGR00201 474186004726 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 474186004727 active site 474186004728 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 474186004729 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 474186004730 ATP binding site [chemical binding]; other site 474186004731 putative Mg++ binding site [ion binding]; other site 474186004732 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 474186004733 nucleotide binding region [chemical binding]; other site 474186004734 ATP-binding site [chemical binding]; other site 474186004735 Predicted ATPase [General function prediction only]; Region: COG3910 474186004736 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 474186004737 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 474186004738 Walker A/P-loop; other site 474186004739 Walker A/P-loop; other site 474186004740 ATP binding site [chemical binding]; other site 474186004741 ATP binding site [chemical binding]; other site 474186004742 Q-loop/lid; other site 474186004743 ABC transporter signature motif; other site 474186004744 Walker B; other site 474186004745 D-loop; other site 474186004746 H-loop/switch region; other site 474186004747 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 474186004748 active site 474186004749 P-loop; other site 474186004750 phosphorylation site [posttranslational modification] 474186004751 Uncharacterized conserved protein [Function unknown]; Region: COG1739 474186004752 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 474186004753 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 474186004754 Protein of unknown function (DUF2829); Region: DUF2829; pfam11195 474186004755 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK06550 474186004756 classical (c) SDRs; Region: SDR_c; cd05233 474186004757 NAD(P) binding site [chemical binding]; other site 474186004758 active site 474186004759 QueT transporter; Region: QueT; pfam06177 474186004760 Tim44-like domain; Region: Tim44; cl09208 474186004761 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 474186004762 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 474186004763 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 474186004764 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 474186004765 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 474186004766 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 474186004767 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 474186004768 purine monophosphate binding site [chemical binding]; other site 474186004769 dimer interface [polypeptide binding]; other site 474186004770 putative catalytic residues [active] 474186004771 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 474186004772 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 474186004773 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 474186004774 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 474186004775 active site 474186004776 substrate binding site [chemical binding]; other site 474186004777 cosubstrate binding site; other site 474186004778 catalytic site [active] 474186004779 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 474186004780 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 474186004781 dimerization interface [polypeptide binding]; other site 474186004782 putative ATP binding site [chemical binding]; other site 474186004783 amidophosphoribosyltransferase; Provisional; Region: PRK07272 474186004784 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 474186004785 active site 474186004786 tetramer interface [polypeptide binding]; other site 474186004787 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 474186004788 active site 474186004789 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 474186004790 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 474186004791 dimerization interface [polypeptide binding]; other site 474186004792 ATP binding site [chemical binding]; other site 474186004793 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 474186004794 dimerization interface [polypeptide binding]; other site 474186004795 ATP binding site [chemical binding]; other site 474186004796 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 474186004797 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 474186004798 putative active site [active] 474186004799 catalytic triad [active] 474186004800 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700 474186004801 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 474186004802 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 474186004803 ATP binding site [chemical binding]; other site 474186004804 active site 474186004805 substrate binding site [chemical binding]; other site 474186004806 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 474186004807 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 474186004808 NAD binding site [chemical binding]; other site 474186004809 ATP-grasp domain; Region: ATP-grasp; pfam02222 474186004810 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 474186004811 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_2; cd03402 474186004812 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 474186004813 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 474186004814 putative substrate binding site [chemical binding]; other site 474186004815 putative ATP binding site [chemical binding]; other site 474186004816 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 474186004817 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 474186004818 peptide binding site [polypeptide binding]; other site 474186004819 Cupin domain; Region: Cupin_2; pfam07883 474186004820 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 474186004821 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 474186004822 homodimer interface [polypeptide binding]; other site 474186004823 substrate-cofactor binding pocket; other site 474186004824 catalytic residue [active] 474186004825 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4876 474186004826 Protein of unknown function (DUF998); Region: DUF998; pfam06197 474186004827 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 474186004828 Domain of unknown function DUF20; Region: UPF0118; pfam01594 474186004829 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 474186004830 Endo-alpha-N-acetylgalactosaminidase; Region: Glyco_hydro_101; pfam12905 474186004831 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 474186004832 active pocket/dimerization site; other site 474186004833 active site 474186004834 phosphorylation site [posttranslational modification] 474186004835 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 474186004836 PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609 474186004837 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 474186004838 active site 474186004839 phosphorylation site [posttranslational modification] 474186004840 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 474186004841 Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301 474186004842 tagatose-6-phosphate kinase; Region: lacC; TIGR01231 474186004843 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 474186004844 putative substrate binding site [chemical binding]; other site 474186004845 putative ATP binding site [chemical binding]; other site 474186004846 tagatose 1,6-diphosphate aldolase; Reviewed; Region: PRK12399 474186004847 putative sugar isomerase, AgaS family; Region: agaS_fam; TIGR02815 474186004848 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 474186004849 dimer interface [polypeptide binding]; other site 474186004850 active site 474186004851 AgaS-like protein. AgaS contains a SIS (Sugar ISomerase) domain which is found in many phosphosugar isomerases and phosphosugar binding proteins. AgaS is a putative isomerase in Escherichia coli. It is similar to the glucosamine-6-phosphate synthases; Region: SIS_AgaS_like; cd05010 474186004852 putative active site [active] 474186004853 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 474186004854 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 474186004855 DNA-binding site [nucleotide binding]; DNA binding site 474186004856 UTRA domain; Region: UTRA; pfam07702 474186004857 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 474186004858 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 474186004859 Ligand binding site; other site 474186004860 metal-binding site 474186004861 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 474186004862 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 474186004863 Ligand binding site; other site 474186004864 metal-binding site 474186004865 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 474186004866 Sulfatase; Region: Sulfatase; pfam00884 474186004867 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 474186004868 Major Facilitator Superfamily; Region: MFS_1; pfam07690 474186004869 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 474186004870 Transcriptional regulator [Transcription]; Region: LysR; COG0583 474186004871 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 474186004872 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 474186004873 putative hydrolase; Provisional; Region: PRK02113 474186004874 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 474186004875 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 474186004876 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 474186004877 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 474186004878 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 474186004879 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 474186004880 active site 474186004881 Zn binding site [ion binding]; other site 474186004882 Oligosaccharyl transferase STT3 subunit; Region: STT3; pfam02516 474186004883 Accessory gene regulator B; Region: AgrB; smart00793 474186004884 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 474186004885 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 474186004886 active site 474186004887 phosphorylation site [posttranslational modification] 474186004888 intermolecular recognition site; other site 474186004889 dimerization interface [polypeptide binding]; other site 474186004890 LytTr DNA-binding domain; Region: LytTR; pfam04397 474186004891 N-acetylmuramoyl-L-alanine amidase; Validated; Region: PRK08581 474186004892 NlpC/P60 family; Region: NLPC_P60; cl17555 474186004893 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 474186004894 CHAP domain; Region: CHAP; pfam05257 474186004895 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 474186004896 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 474186004897 CPE1046 is an uncharacterized Clostridium perfringens protein with a glycosyl hydrolase family 31 (GH31) domain. The domain architecture of CPE1046 and its orthologs includes a C-terminal fibronectin type 3 (FN3) domain and a coagulation factor 5/8 type...; Region: GH31_CPE1046; cd06596 474186004898 putative active site [active] 474186004899 putative catalytic site [active] 474186004900 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 474186004901 Interdomain contacts; other site 474186004902 Cytokine receptor motif; other site 474186004903 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 474186004904 Cohesin domain, interaction partner of dockerin; Region: Type_III_cohesin_like; cd08759 474186004905 putative dockerin binding interface; other site 474186004906 ATP synthase B/B' CF(0); Region: ATP-synt_B; pfam00430 474186004907 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 474186004908 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 474186004909 NAD binding site [chemical binding]; other site 474186004910 substrate binding site [chemical binding]; other site 474186004911 catalytic Zn binding site [ion binding]; other site 474186004912 tetramer interface [polypeptide binding]; other site 474186004913 structural Zn binding site [ion binding]; other site 474186004914 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 474186004915 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 474186004916 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 474186004917 Mga helix-turn-helix domain; Region: Mga; pfam05043 474186004918 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 474186004919 ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606 474186004920 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_I; cd01990 474186004921 Ligand Binding Site [chemical binding]; other site 474186004922 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 474186004923 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 474186004924 Walker A/P-loop; other site 474186004925 ATP binding site [chemical binding]; other site 474186004926 Q-loop/lid; other site 474186004927 ABC transporter signature motif; other site 474186004928 Walker B; other site 474186004929 D-loop; other site 474186004930 H-loop/switch region; other site 474186004931 Cobalt transport protein; Region: CbiQ; cl00463 474186004932 cobalt transport protein CbiM; Provisional; Region: PRK07331 474186004933 cobalt transport protein CbiM; Provisional; Region: PRK11909 474186004934 PDGLE domain; Region: PDGLE; pfam13190 474186004935 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 474186004936 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 474186004937 ligand binding site [chemical binding]; other site 474186004938 flexible hinge region; other site 474186004939 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 474186004940 Domain of unknown function (DUF2088); Region: DUF2088; cl15406 474186004941 NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691 474186004942 AIR carboxylase; Region: AIRC; smart01001 474186004943 Protein of unknown function DUF111; Region: DUF111; pfam01969 474186004944 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 474186004945 amphipathic channel; other site 474186004946 Asn-Pro-Ala signature motifs; other site 474186004947 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 474186004948 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 474186004949 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cl00021 474186004950 active site 474186004951 phosphorylation site [posttranslational modification] 474186004952 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 474186004953 active pocket/dimerization site; other site 474186004954 active site 474186004955 phosphorylation site [posttranslational modification] 474186004956 galactose-6-phosphate isomerase subunit LacB; Reviewed; Region: PRK08622 474186004957 galactose-6-phosphate isomerase subunit LacA; Reviewed; Region: PRK08621 474186004958 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 474186004959 active site 474186004960 phosphorylation site [posttranslational modification] 474186004961 Phosphotransferase system, galactitol-specific IIB component [Carbohydrate transport and metabolism]; Region: SgaB; COG3414 474186004962 active site 474186004963 P-loop; other site 474186004964 phosphorylation site [posttranslational modification] 474186004965 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 474186004966 PTS system sugar-specific permease component; Region: EIIC-GAT; pfam03611 474186004967 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 474186004968 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 474186004969 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 474186004970 Toxin co-regulated pilus biosynthesis protein Q; Region: TcpQ; pfam10671 474186004971 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 474186004972 Zn2+ binding site [ion binding]; other site 474186004973 Mg2+ binding site [ion binding]; other site 474186004974 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 474186004975 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 474186004976 NodB motif; other site 474186004977 active site 474186004978 catalytic site [active] 474186004979 Zn binding site [ion binding]; other site 474186004980 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 474186004981 Ribosomal protein L19 leader; OG1RF_nc10023 474186004982 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 474186004983 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 474186004984 RimM N-terminal domain; Region: RimM; pfam01782 474186004985 PRC-barrel domain; Region: PRC; pfam05239 474186004986 manganese transport protein MntH; Reviewed; Region: PRK00701 474186004987 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 474186004988 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 474186004989 Mitomycin C resistance protein (MRD); Region: MRD; cd07235 474186004990 dimer interface [polypeptide binding]; other site 474186004991 ligand binding site [chemical binding]; other site 474186004992 Uncharacterized conserved protein [Function unknown]; Region: COG0398 474186004993 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 474186004994 Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; pfam10110 474186004995 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 474186004996 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579 474186004997 putative active site [active] 474186004998 catalytic site [active] 474186004999 putative metal binding site [ion binding]; other site 474186005000 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 474186005001 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 474186005002 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 474186005003 dimer interaction site [polypeptide binding]; other site 474186005004 substrate-binding tunnel; other site 474186005005 active site 474186005006 catalytic site [active] 474186005007 substrate binding site [chemical binding]; other site 474186005008 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 474186005009 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 474186005010 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 474186005011 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 474186005012 Predicted membrane protein [Function unknown]; Region: COG4129 474186005013 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 474186005014 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 474186005015 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 474186005016 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 474186005017 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 474186005018 nucleotide binding site [chemical binding]; other site 474186005019 Haemolytic domain; Region: Haemolytic; pfam01809 474186005020 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 474186005021 G1 box; other site 474186005022 GTP/Mg2+ binding site [chemical binding]; other site 474186005023 Switch I region; other site 474186005024 G2 box; other site 474186005025 G3 box; other site 474186005026 Switch II region; other site 474186005027 G4 box; other site 474186005028 G5 box; other site 474186005029 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 474186005030 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 474186005031 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 474186005032 Walker A motif; other site 474186005033 ATP binding site [chemical binding]; other site 474186005034 Walker B motif; other site 474186005035 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 474186005036 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 474186005037 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 474186005038 Coenzyme A binding pocket [chemical binding]; other site 474186005039 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 474186005040 C4-dicarboxylate transporter [Energy production and conversion]; Region: DcuC; cl17322 474186005041 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 474186005042 active site 474186005043 tetramer interface [polypeptide binding]; other site 474186005044 Transcriptional regulators [Transcription]; Region: PurR; COG1609 474186005045 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 474186005046 DNA binding site [nucleotide binding] 474186005047 Ligand-binding domain of a transcription repressor, FucR, which functions as a molecular sensor of L-fucose availability; Region: PBP1_FucR_like; cd06276 474186005048 putative dimerization interface [polypeptide binding]; other site 474186005049 putative ligand binding site [chemical binding]; other site 474186005050 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 474186005051 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 474186005052 substrate binding site [chemical binding]; other site 474186005053 dimer interface [polypeptide binding]; other site 474186005054 ATP binding site [chemical binding]; other site 474186005055 Mga helix-turn-helix domain; Region: Mga; pfam05043 474186005056 5-bromo-4-chloroindolyl phosphate hydrolysis protein; Region: Halogen_Hydrol; pfam10112 474186005057 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 474186005058 amphipathic channel; other site 474186005059 Asn-Pro-Ala signature motifs; other site 474186005060 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 474186005061 glycerol kinase; Provisional; Region: glpK; PRK00047 474186005062 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 474186005063 N- and C-terminal domain interface [polypeptide binding]; other site 474186005064 active site 474186005065 MgATP binding site [chemical binding]; other site 474186005066 catalytic site [active] 474186005067 metal binding site [ion binding]; metal-binding site 474186005068 glycerol binding site [chemical binding]; other site 474186005069 homotetramer interface [polypeptide binding]; other site 474186005070 homodimer interface [polypeptide binding]; other site 474186005071 FBP binding site [chemical binding]; other site 474186005072 protein IIAGlc interface [polypeptide binding]; other site 474186005073 Mga helix-turn-helix domain; Region: Mga; pfam05043 474186005074 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 474186005075 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 474186005076 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 474186005077 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 474186005078 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 474186005079 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 474186005080 Ca binding site [ion binding]; other site 474186005081 active site 474186005082 catalytic site [active] 474186005083 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 474186005084 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 474186005085 active site turn [active] 474186005086 phosphorylation site [posttranslational modification] 474186005087 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 474186005088 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 474186005089 DNA-binding site [nucleotide binding]; DNA binding site 474186005090 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 474186005091 UTRA domain; Region: UTRA; pfam07702 474186005092 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 474186005093 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 474186005094 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 474186005095 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 474186005096 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 474186005097 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 474186005098 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 474186005099 yybP-ykoY leader; OG1RF_nc10024 474186005100 Predicted membrane protein [Function unknown]; Region: COG2364 474186005101 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 474186005102 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 474186005103 ligand binding site [chemical binding]; other site 474186005104 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 474186005105 putative switch regulator; other site 474186005106 non-specific DNA interactions [nucleotide binding]; other site 474186005107 DNA binding site [nucleotide binding] 474186005108 sequence specific DNA binding site [nucleotide binding]; other site 474186005109 putative cAMP binding site [chemical binding]; other site 474186005110 Protein of unknown function (DUF3224); Region: DUF3224; pfam11528 474186005111 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 474186005112 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 474186005113 putative substrate translocation pore; other site 474186005114 Sulfatase; Region: Sulfatase; pfam00884 474186005115 Domain of unknown function (DU1801); Region: DUF1801; cl17490 474186005116 Uncharacterized protein conserved in bacteria (DUF2200); Region: DUF2200; pfam09966 474186005117 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 474186005118 A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710 474186005119 putative active site [active] 474186005120 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 474186005121 Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains [Cell envelope biogenesis, outer membrane]; Region: GlmS; COG0449 474186005122 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 474186005123 dimer interface [polypeptide binding]; other site 474186005124 active site 474186005125 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 474186005126 dimer interface [polypeptide binding]; other site 474186005127 active site 474186005128 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 474186005129 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 474186005130 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 474186005131 active site 474186005132 phosphorylation site [posttranslational modification] 474186005133 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 474186005134 active pocket/dimerization site; other site 474186005135 active site 474186005136 phosphorylation site [posttranslational modification] 474186005137 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 474186005138 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 474186005139 Walker A motif; other site 474186005140 ATP binding site [chemical binding]; other site 474186005141 Walker B motif; other site 474186005142 arginine finger; other site 474186005143 Transcriptional antiterminator [Transcription]; Region: COG3933 474186005144 PRD domain; Region: PRD; pfam00874 474186005145 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 474186005146 active pocket/dimerization site; other site 474186005147 active site 474186005148 phosphorylation site [posttranslational modification] 474186005149 PRD domain; Region: PRD; pfam00874 474186005150 sporadically distributed protein, TIGR04141 family; Region: TIGR04141 474186005151 sporadically distributed protein, TIGR04141 family; Region: TIGR04141 474186005152 TIR domain; Region: TIR_2; cl17458 474186005153 Catalytic domain of type II restriction endonucleases BfiI and NgoFVII, and uncharacterized proteins with a DEAD domain; Region: PLDc_Bfil_DEXD_like; cd09117 474186005154 homodimer interface [polypeptide binding]; other site 474186005155 putative active site [active] 474186005156 catalytic site [active] 474186005157 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 474186005158 C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145 474186005159 cofactor binding site; other site 474186005160 DNA binding site [nucleotide binding] 474186005161 substrate interaction site [chemical binding]; other site 474186005162 enolase; Provisional; Region: eno; PRK00077 474186005163 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 474186005164 dimer interface [polypeptide binding]; other site 474186005165 metal binding site [ion binding]; metal-binding site 474186005166 substrate binding pocket [chemical binding]; other site 474186005167 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 474186005168 triosephosphate isomerase; Provisional; Region: PRK14565 474186005169 substrate binding site [chemical binding]; other site 474186005170 dimer interface [polypeptide binding]; other site 474186005171 catalytic triad [active] 474186005172 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 474186005173 Phosphoglycerate kinase; Region: PGK; pfam00162 474186005174 substrate binding site [chemical binding]; other site 474186005175 hinge regions; other site 474186005176 ADP binding site [chemical binding]; other site 474186005177 catalytic site [active] 474186005178 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 474186005179 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 474186005180 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 474186005181 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 474186005182 Predicted transcriptional regulator [Transcription]; Region: COG3388 474186005183 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 474186005184 Uncharacterized conserved protein [Function unknown]; Region: COG1284 474186005185 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 474186005186 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 474186005187 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 474186005188 Protein of unknown function (DUF436); Region: DUF436; pfam04260 474186005189 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; pfam07155 474186005190 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 474186005191 dimer interface [polypeptide binding]; other site 474186005192 substrate binding site [chemical binding]; other site 474186005193 ATP binding site [chemical binding]; other site 474186005194 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 474186005195 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 474186005196 dimer interface [polypeptide binding]; other site 474186005197 anticodon binding site; other site 474186005198 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 474186005199 homodimer interface [polypeptide binding]; other site 474186005200 motif 1; other site 474186005201 active site 474186005202 motif 2; other site 474186005203 GAD domain; Region: GAD; pfam02938 474186005204 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 474186005205 motif 3; other site 474186005206 histidyl-tRNA synthetase; Region: hisS; TIGR00442 474186005207 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 474186005208 dimer interface [polypeptide binding]; other site 474186005209 motif 1; other site 474186005210 active site 474186005211 motif 2; other site 474186005212 motif 3; other site 474186005213 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 474186005214 anticodon binding site; other site 474186005215 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 474186005216 putative active site [active] 474186005217 dimerization interface [polypeptide binding]; other site 474186005218 putative tRNAtyr binding site [nucleotide binding]; other site 474186005219 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 474186005220 HD domain; Region: HD_4; pfam13328 474186005221 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 474186005222 synthetase active site [active] 474186005223 NTP binding site [chemical binding]; other site 474186005224 metal binding site [ion binding]; metal-binding site 474186005225 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 474186005226 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 474186005227 RNA methyltransferase, RsmE family; Region: TIGR00046 474186005228 RNA methyltransferase; Region: Methyltrans_RNA; pfam04452 474186005229 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 474186005230 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 474186005231 S-adenosylmethionine binding site [chemical binding]; other site 474186005232 Protein of unknown function (DUF3013); Region: DUF3013; pfam11217 474186005233 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 474186005234 active site 474186005235 DNA binding site [nucleotide binding] 474186005236 recombination factor protein RarA; Reviewed; Region: PRK13342 474186005237 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 474186005238 Walker A motif; other site 474186005239 ATP binding site [chemical binding]; other site 474186005240 Walker B motif; other site 474186005241 arginine finger; other site 474186005242 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 474186005243 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 474186005244 Ligand Binding Site [chemical binding]; other site 474186005245 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 474186005246 propionate/acetate kinase; Provisional; Region: PRK12379 474186005247 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 474186005248 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 474186005249 S-adenosylmethionine binding site [chemical binding]; other site 474186005250 Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940 474186005251 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 474186005252 hypothetical protein; Provisional; Region: PRK10506 474186005253 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 474186005254 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 474186005255 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 474186005256 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 474186005257 Walker A motif; other site 474186005258 ATP binding site [chemical binding]; other site 474186005259 Walker B motif; other site 474186005260 amino acid transporter; Region: 2A0306; TIGR00909 474186005261 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 474186005262 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 474186005263 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 474186005264 FeS/SAM binding site; other site 474186005265 FtsX-like permease family; Region: FtsX; pfam02687 474186005266 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 474186005267 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 474186005268 Walker A/P-loop; other site 474186005269 ATP binding site [chemical binding]; other site 474186005270 Q-loop/lid; other site 474186005271 ABC transporter signature motif; other site 474186005272 Walker B; other site 474186005273 D-loop; other site 474186005274 H-loop/switch region; other site 474186005275 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 474186005276 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 474186005277 DNA-binding site [nucleotide binding]; DNA binding site 474186005278 UTRA domain; Region: UTRA; pfam07702 474186005279 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 474186005280 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 474186005281 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 474186005282 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 474186005283 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 474186005284 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 474186005285 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 474186005286 UbiA prenyltransferase family; Region: UbiA; pfam01040 474186005287 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 474186005288 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 474186005289 substrate binding pocket [chemical binding]; other site 474186005290 chain length determination region; other site 474186005291 substrate-Mg2+ binding site; other site 474186005292 catalytic residues [active] 474186005293 aspartate-rich region 1; other site 474186005294 active site lid residues [active] 474186005295 aspartate-rich region 2; other site 474186005296 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 474186005297 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 474186005298 ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247 474186005299 Walker A/P-loop; other site 474186005300 ATP binding site [chemical binding]; other site 474186005301 Q-loop/lid; other site 474186005302 ABC transporter signature motif; other site 474186005303 Walker B; other site 474186005304 D-loop; other site 474186005305 H-loop/switch region; other site 474186005306 thiol reductant ABC exporter, CydD subunit; Region: CydD; TIGR02857 474186005307 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 474186005308 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 474186005309 Walker A/P-loop; other site 474186005310 ATP binding site [chemical binding]; other site 474186005311 Q-loop/lid; other site 474186005312 ABC transporter signature motif; other site 474186005313 Walker B; other site 474186005314 D-loop; other site 474186005315 H-loop/switch region; other site 474186005316 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 474186005317 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 474186005318 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 474186005319 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 474186005320 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 474186005321 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 474186005322 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 474186005323 DNA topoisomerase III; Provisional; Region: PRK07726 474186005324 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 474186005325 active site 474186005326 putative interdomain interaction site [polypeptide binding]; other site 474186005327 putative metal-binding site [ion binding]; other site 474186005328 putative nucleotide binding site [chemical binding]; other site 474186005329 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 474186005330 domain I; other site 474186005331 DNA binding groove [nucleotide binding] 474186005332 phosphate binding site [ion binding]; other site 474186005333 domain II; other site 474186005334 domain III; other site 474186005335 nucleotide binding site [chemical binding]; other site 474186005336 catalytic site [active] 474186005337 domain IV; other site 474186005338 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 474186005339 Protein of unknown function (DUF1033); Region: DUF1033; pfam06279 474186005340 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 474186005341 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 474186005342 WHG domain; Region: WHG; pfam13305 474186005343 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 474186005344 substrate binding site [chemical binding]; other site 474186005345 drug efflux system protein MdtG; Provisional; Region: PRK09874 474186005346 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 474186005347 putative substrate translocation pore; other site 474186005348 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 474186005349 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 474186005350 Putative amino acid metabolism; Region: DUF1831; pfam08866 474186005351 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 474186005352 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 474186005353 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 474186005354 catalytic residue [active] 474186005355 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02458 474186005356 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 474186005357 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 474186005358 active site 474186005359 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 474186005360 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 474186005361 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 474186005362 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 474186005363 ABC-ATPase subunit interface; other site 474186005364 dimer interface [polypeptide binding]; other site 474186005365 putative PBP binding regions; other site 474186005366 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 474186005367 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 474186005368 metal binding site [ion binding]; metal-binding site 474186005369 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 474186005370 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 474186005371 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 474186005372 ABC transporter; Region: ABC_tran_2; pfam12848 474186005373 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 474186005374 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 474186005375 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_subfamily5; cd08019 474186005376 metal binding site [ion binding]; metal-binding site 474186005377 putative dimer interface [polypeptide binding]; other site 474186005378 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 474186005379 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 474186005380 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 474186005381 dimer interface [polypeptide binding]; other site 474186005382 conserved gate region; other site 474186005383 ABC-ATPase subunit interface; other site 474186005384 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 474186005385 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 474186005386 Walker A/P-loop; other site 474186005387 ATP binding site [chemical binding]; other site 474186005388 Q-loop/lid; other site 474186005389 ABC transporter signature motif; other site 474186005390 Walker B; other site 474186005391 D-loop; other site 474186005392 H-loop/switch region; other site 474186005393 NIL domain; Region: NIL; pfam09383 474186005394 T-box leader; OG1RF_nc10026 474186005395 T-box leader; OG1RF_nc10027 474186005396 Glucosyl transferase GtrII; Region: Glucos_trans_II; pfam14264 474186005397 FemAB family; Region: FemAB; pfam02388 474186005398 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 474186005399 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 474186005400 glutaminase active site [active] 474186005401 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 474186005402 dimer interface [polypeptide binding]; other site 474186005403 active site 474186005404 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 474186005405 dimer interface [polypeptide binding]; other site 474186005406 active site 474186005407 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 474186005408 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 474186005409 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 474186005410 Walker A/P-loop; other site 474186005411 ATP binding site [chemical binding]; other site 474186005412 Q-loop/lid; other site 474186005413 ABC transporter signature motif; other site 474186005414 Walker B; other site 474186005415 D-loop; other site 474186005416 H-loop/switch region; other site 474186005417 ATP-binding cassette cobalt transporter; Region: DUF3744; pfam12558 474186005418 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 474186005419 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 474186005420 Walker A/P-loop; other site 474186005421 ATP binding site [chemical binding]; other site 474186005422 Q-loop/lid; other site 474186005423 ABC transporter signature motif; other site 474186005424 Walker B; other site 474186005425 D-loop; other site 474186005426 H-loop/switch region; other site 474186005427 hypothetical protein; Provisional; Region: PRK13661 474186005428 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 474186005429 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 474186005430 active site 474186005431 substrate binding site [chemical binding]; other site 474186005432 metal binding site [ion binding]; metal-binding site 474186005433 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 474186005434 YbbR-like protein; Region: YbbR; pfam07949 474186005435 Uncharacterized conserved protein [Function unknown]; Region: COG1624 474186005436 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 474186005437 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 474186005438 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 474186005439 dimer interface [polypeptide binding]; other site 474186005440 PYR/PP interface [polypeptide binding]; other site 474186005441 TPP binding site [chemical binding]; other site 474186005442 substrate binding site [chemical binding]; other site 474186005443 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 474186005444 Domain of unknown function; Region: EKR; smart00890 474186005445 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 474186005446 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 474186005447 TPP-binding site [chemical binding]; other site 474186005448 dimer interface [polypeptide binding]; other site 474186005449 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 474186005450 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 474186005451 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 474186005452 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 474186005453 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 474186005454 DNA binding residues [nucleotide binding] 474186005455 putative dimer interface [polypeptide binding]; other site 474186005456 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 474186005457 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 474186005458 HflX GTPase family; Region: HflX; cd01878 474186005459 G1 box; other site 474186005460 GTP/Mg2+ binding site [chemical binding]; other site 474186005461 Switch I region; other site 474186005462 G2 box; other site 474186005463 G3 box; other site 474186005464 Switch II region; other site 474186005465 G4 box; other site 474186005466 G5 box; other site 474186005467 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 474186005468 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 474186005469 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 474186005470 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 474186005471 active site 474186005472 catalytic site [active] 474186005473 metal binding site [ion binding]; metal-binding site 474186005474 dimer interface [polypeptide binding]; other site 474186005475 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 474186005476 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 474186005477 Ligand binding site; other site 474186005478 Putative Catalytic site; other site 474186005479 DXD motif; other site 474186005480 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 474186005481 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 474186005482 NAD(P) binding site [chemical binding]; other site 474186005483 active site 474186005484 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 474186005485 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 474186005486 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 474186005487 O-Antigen ligase; Region: Wzy_C; pfam04932 474186005488 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 474186005489 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 474186005490 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 474186005491 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 474186005492 active site 474186005493 nucleotide binding site [chemical binding]; other site 474186005494 HIGH motif; other site 474186005495 KMSKS motif; other site 474186005496 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 474186005497 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 474186005498 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 474186005499 active site 474186005500 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 474186005501 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 474186005502 active site 474186005503 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 474186005504 active site 474186005505 Transposase; Region: DDE_Tnp_ISL3; pfam01610 474186005506 AtlA is an autolysin found in Gram-positive lactic acid bacteria that degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. This family includes the AtlA and Aml...; Region: GH25_AtlA-like; cd06522 474186005507 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 474186005508 active site 474186005509 LicD family; Region: LicD; cl01378 474186005510 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 474186005511 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 474186005512 active site 474186005513 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 474186005514 Bacterial sugar transferase; Region: Bac_transf; pfam02397 474186005515 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 474186005516 Myxococcus xanthus RfbC like proteins are required for O-antigen biosynthesis; Region: GT2_RfbC_Mx_like; cd04184 474186005517 Probable Catalytic site; other site 474186005518 metal-binding site 474186005519 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 474186005520 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 474186005521 Probable Catalytic site; other site 474186005522 metal-binding site 474186005523 Methyltransferase domain; Region: Methyltransf_23; pfam13489 474186005524 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 474186005525 S-adenosylmethionine binding site [chemical binding]; other site 474186005526 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 474186005527 Myxococcus xanthus RfbC like proteins are required for O-antigen biosynthesis; Region: GT2_RfbC_Mx_like; cd04184 474186005528 Probable Catalytic site; other site 474186005529 metal-binding site 474186005530 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 474186005531 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 474186005532 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 474186005533 Walker A/P-loop; other site 474186005534 ATP binding site [chemical binding]; other site 474186005535 Q-loop/lid; other site 474186005536 ABC transporter signature motif; other site 474186005537 Walker B; other site 474186005538 D-loop; other site 474186005539 H-loop/switch region; other site 474186005540 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 474186005541 putative carbohydrate binding site [chemical binding]; other site 474186005542 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 474186005543 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 474186005544 Uncharacterized conserved protein (DUF2304); Region: DUF2304; cl01034 474186005545 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 474186005546 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 474186005547 Ligand binding site; other site 474186005548 Putative Catalytic site; other site 474186005549 DXD motif; other site 474186005550 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 474186005551 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 474186005552 NADP binding site [chemical binding]; other site 474186005553 active site 474186005554 putative substrate binding site [chemical binding]; other site 474186005555 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 474186005556 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 474186005557 NAD binding site [chemical binding]; other site 474186005558 substrate binding site [chemical binding]; other site 474186005559 homodimer interface [polypeptide binding]; other site 474186005560 active site 474186005561 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 474186005562 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 474186005563 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 474186005564 substrate binding site; other site 474186005565 tetramer interface; other site 474186005566 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 474186005567 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196 474186005568 Probable Catalytic site; other site 474186005569 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 474186005570 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 474186005571 active site 474186005572 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 474186005573 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 474186005574 Probable Catalytic site; other site 474186005575 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 474186005576 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 474186005577 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 474186005578 Mg++ binding site [ion binding]; other site 474186005579 putative catalytic motif [active] 474186005580 substrate binding site [chemical binding]; other site 474186005581 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 474186005582 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 474186005583 active site 474186005584 flavodoxin; Validated; Region: PRK07308 474186005585 TspO/MBR family; Region: TspO_MBR; pfam03073 474186005586 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 474186005587 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 474186005588 WHG domain; Region: WHG; pfam13305 474186005589 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 474186005590 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 474186005591 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 474186005592 pentamer interface [polypeptide binding]; other site 474186005593 dodecaamer interface [polypeptide binding]; other site 474186005594 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 474186005595 nucleoside/Zn binding site; other site 474186005596 dimer interface [polypeptide binding]; other site 474186005597 catalytic motif [active] 474186005598 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 474186005599 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 474186005600 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298 474186005601 Protein of unknown function (DUF1093); Region: DUF1093; cl02185 474186005602 37-kD nucleoid-associated bacterial protein; Region: NA37; cl15473 474186005603 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 474186005604 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 474186005605 active site turn [active] 474186005606 phosphorylation site [posttranslational modification] 474186005607 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 474186005608 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 474186005609 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 474186005610 putative metal binding site [ion binding]; other site 474186005611 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 474186005612 putative hydrophobic ligand binding site [chemical binding]; other site 474186005613 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 474186005614 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 474186005615 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 474186005616 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 474186005617 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 474186005618 active site 474186005619 phosphorylation site [posttranslational modification] 474186005620 intermolecular recognition site; other site 474186005621 dimerization interface [polypeptide binding]; other site 474186005622 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 474186005623 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 474186005624 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 474186005625 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 474186005626 Histidine kinase; Region: His_kinase; pfam06580 474186005627 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 474186005628 ATP binding site [chemical binding]; other site 474186005629 Mg2+ binding site [ion binding]; other site 474186005630 G-X-G motif; other site 474186005631 Protein of unknown function, DUF624; Region: DUF624; cl02369 474186005632 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 474186005633 Domain of unknown function (DUF3502); Region: DUF3502; pfam12010 474186005634 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 474186005635 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 474186005636 dimer interface [polypeptide binding]; other site 474186005637 ABC-ATPase subunit interface; other site 474186005638 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 474186005639 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 474186005640 dimer interface [polypeptide binding]; other site 474186005641 conserved gate region; other site 474186005642 putative PBP binding loops; other site 474186005643 ABC-ATPase subunit interface; other site 474186005644 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 474186005645 conserved repeat domain; Region: B_ant_repeat; TIGR01451 474186005646 conserved repeat domain; Region: B_ant_repeat; TIGR01451 474186005647 conserved repeat domain; Region: B_ant_repeat; TIGR01451 474186005648 conserved repeat domain; Region: B_ant_repeat; TIGR01451 474186005649 conserved repeat domain; Region: B_ant_repeat; TIGR01451 474186005650 conserved repeat domain; Region: B_ant_repeat; TIGR01451 474186005651 conserved repeat domain; Region: B_ant_repeat; TIGR01451 474186005652 conserved repeat domain; Region: B_ant_repeat; TIGR01451 474186005653 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 474186005654 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 474186005655 DNA binding residues [nucleotide binding] 474186005656 dimer interface [polypeptide binding]; other site 474186005657 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 474186005658 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 474186005659 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 474186005660 Walker A/P-loop; other site 474186005661 ATP binding site [chemical binding]; other site 474186005662 Q-loop/lid; other site 474186005663 ABC transporter signature motif; other site 474186005664 Walker B; other site 474186005665 D-loop; other site 474186005666 H-loop/switch region; other site 474186005667 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 474186005668 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 474186005669 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 474186005670 Walker A/P-loop; other site 474186005671 ATP binding site [chemical binding]; other site 474186005672 Q-loop/lid; other site 474186005673 ABC transporter signature motif; other site 474186005674 Walker B; other site 474186005675 D-loop; other site 474186005676 H-loop/switch region; other site 474186005677 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 474186005678 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 474186005679 active site 474186005680 HIGH motif; other site 474186005681 dimer interface [polypeptide binding]; other site 474186005682 KMSKS motif; other site 474186005683 Right handed beta helix region; Region: Beta_helix; pfam13229 474186005684 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 474186005685 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 474186005686 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 474186005687 V-type ATP synthase subunit I; Validated; Region: PRK05771 474186005688 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 474186005689 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 474186005690 dimer interface [polypeptide binding]; other site 474186005691 conserved gate region; other site 474186005692 putative PBP binding loops; other site 474186005693 ABC-ATPase subunit interface; other site 474186005694 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 474186005695 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 474186005696 dimer interface [polypeptide binding]; other site 474186005697 conserved gate region; other site 474186005698 putative PBP binding loops; other site 474186005699 ABC-ATPase subunit interface; other site 474186005700 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 474186005701 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 474186005702 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 474186005703 Uncharacterized protein conserved in bacteria (DUF2264); Region: DUF2264; pfam10022 474186005704 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 474186005705 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 474186005706 generic binding surface I; other site 474186005707 generic binding surface II; other site 474186005708 Transcriptional regulators [Transcription]; Region: PurR; COG1609 474186005709 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 474186005710 DNA binding site [nucleotide binding] 474186005711 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 474186005712 putative dimerization interface [polypeptide binding]; other site 474186005713 putative ligand binding site [chemical binding]; other site 474186005714 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 474186005715 active site 474186005716 P-loop; other site 474186005717 phosphorylation site [posttranslational modification] 474186005718 putative transporter; Provisional; Region: PRK10484 474186005719 uncharacterized SLC5 subfamily, Escherichia coli YidK-like; solute binding domain; Region: SLC5sbd_YidK; cd10328 474186005720 Na binding site [ion binding]; other site 474186005721 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 474186005722 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 474186005723 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 474186005724 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 474186005725 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 474186005726 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 474186005727 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 474186005728 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 474186005729 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 474186005730 tetrameric interface [polypeptide binding]; other site 474186005731 NAD binding site [chemical binding]; other site 474186005732 catalytic residues [active] 474186005733 Uncharacterized enzyme involved in inositol metabolism [Carbohydrate transport and metabolism]; Region: IolB; COG3718 474186005734 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 474186005735 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 474186005736 PYR/PP interface [polypeptide binding]; other site 474186005737 dimer interface [polypeptide binding]; other site 474186005738 TPP binding site [chemical binding]; other site 474186005739 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 474186005740 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 474186005741 TPP-binding site; other site 474186005742 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 474186005743 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 474186005744 substrate binding site [chemical binding]; other site 474186005745 ATP binding site [chemical binding]; other site 474186005746 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 474186005747 DNA binding site [nucleotide binding] 474186005748 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 474186005749 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 474186005750 GTP-binding protein LepA; Provisional; Region: PRK05433 474186005751 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 474186005752 G1 box; other site 474186005753 putative GEF interaction site [polypeptide binding]; other site 474186005754 GTP/Mg2+ binding site [chemical binding]; other site 474186005755 Switch I region; other site 474186005756 G2 box; other site 474186005757 G3 box; other site 474186005758 Switch II region; other site 474186005759 G4 box; other site 474186005760 G5 box; other site 474186005761 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 474186005762 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 474186005763 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 474186005764 Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527 474186005765 Sterol carrier protein domain; Region: SCP2_2; pfam13530 474186005766 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014 474186005767 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 474186005768 Clp amino terminal domain; Region: Clp_N; pfam02861 474186005769 Clp amino terminal domain; Region: Clp_N; pfam02861 474186005770 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 474186005771 Walker A motif; other site 474186005772 ATP binding site [chemical binding]; other site 474186005773 Walker B motif; other site 474186005774 arginine finger; other site 474186005775 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 474186005776 Walker A motif; other site 474186005777 ATP binding site [chemical binding]; other site 474186005778 Walker B motif; other site 474186005779 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 474186005780 DoxX; Region: DoxX; pfam07681 474186005781 adenylosuccinate lyase; Provisional; Region: PRK07492 474186005782 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 474186005783 tetramer interface [polypeptide binding]; other site 474186005784 active site 474186005785 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 474186005786 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 474186005787 NAD binding site [chemical binding]; other site 474186005788 ATP-grasp domain; Region: ATP-grasp; pfam02222 474186005789 xanthine permease; Region: pbuX; TIGR03173 474186005790 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 474186005791 active site 474186005792 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 474186005793 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 474186005794 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 474186005795 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 474186005796 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 474186005797 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 474186005798 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 474186005799 putative dimer interface [polypeptide binding]; other site 474186005800 putative anticodon binding site; other site 474186005801 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 474186005802 homodimer interface [polypeptide binding]; other site 474186005803 motif 1; other site 474186005804 motif 2; other site 474186005805 active site 474186005806 motif 3; other site 474186005807 aspartate aminotransferase; Provisional; Region: PRK05764 474186005808 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 474186005809 pyridoxal 5'-phosphate binding site [chemical binding]; other site 474186005810 homodimer interface [polypeptide binding]; other site 474186005811 catalytic residue [active] 474186005812 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 474186005813 DnaQ family exonuclease/DinG family helicase, putative; Region: dinG_rel; TIGR01407 474186005814 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 474186005815 active site 474186005816 catalytic site [active] 474186005817 substrate binding site [chemical binding]; other site 474186005818 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 474186005819 ATP binding site [chemical binding]; other site 474186005820 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 474186005821 Amino acid permease; Region: AA_permease_2; pfam13520 474186005822 DNA polymerase III PolC; Validated; Region: polC; PRK00448 474186005823 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 474186005824 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 474186005825 generic binding surface II; other site 474186005826 generic binding surface I; other site 474186005827 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 474186005828 active site 474186005829 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 474186005830 active site 474186005831 catalytic site [active] 474186005832 substrate binding site [chemical binding]; other site 474186005833 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 474186005834 prolyl-tRNA synthetase; Provisional; Region: PRK09194 474186005835 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 474186005836 dimer interface [polypeptide binding]; other site 474186005837 motif 1; other site 474186005838 active site 474186005839 motif 2; other site 474186005840 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 474186005841 putative deacylase active site [active] 474186005842 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 474186005843 active site 474186005844 motif 3; other site 474186005845 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 474186005846 anticodon binding site; other site 474186005847 RIP metalloprotease RseP; Region: TIGR00054 474186005848 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 474186005849 active site 474186005850 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 474186005851 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 474186005852 protein binding site [polypeptide binding]; other site 474186005853 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 474186005854 putative substrate binding region [chemical binding]; other site 474186005855 glucose-1-dehydrogenase; Provisional; Region: PRK08936 474186005856 glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358 474186005857 NAD binding site [chemical binding]; other site 474186005858 homodimer interface [polypeptide binding]; other site 474186005859 active site 474186005860 Predicted membrane protein [Function unknown]; Region: COG2364 474186005861 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c_3; pfam13589 474186005862 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 474186005863 S-adenosylmethionine binding site [chemical binding]; other site 474186005864 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 474186005865 FeS assembly protein SufB; Region: sufB; TIGR01980 474186005866 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 474186005867 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 474186005868 trimerization site [polypeptide binding]; other site 474186005869 active site 474186005870 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 474186005871 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 474186005872 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 474186005873 catalytic residue [active] 474186005874 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 474186005875 FeS assembly protein SufD; Region: sufD; TIGR01981 474186005876 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 474186005877 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 474186005878 Walker A/P-loop; other site 474186005879 ATP binding site [chemical binding]; other site 474186005880 Q-loop/lid; other site 474186005881 ABC transporter signature motif; other site 474186005882 Walker B; other site 474186005883 D-loop; other site 474186005884 H-loop/switch region; other site 474186005885 ribosome recycling factor; Reviewed; Region: frr; PRK00083 474186005886 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 474186005887 hinge region; other site 474186005888 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 474186005889 putative nucleotide binding site [chemical binding]; other site 474186005890 uridine monophosphate binding site [chemical binding]; other site 474186005891 homohexameric interface [polypeptide binding]; other site 474186005892 elongation factor Ts; Provisional; Region: tsf; PRK09377 474186005893 UBA/TS-N domain; Region: UBA; pfam00627 474186005894 Elongation factor TS; Region: EF_TS; pfam00889 474186005895 Elongation factor TS; Region: EF_TS; pfam00889 474186005896 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 474186005897 rRNA interaction site [nucleotide binding]; other site 474186005898 S8 interaction site; other site 474186005899 putative laminin-1 binding site; other site 474186005900 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 474186005901 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 474186005902 Coenzyme A binding pocket [chemical binding]; other site 474186005903 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 474186005904 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 474186005905 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 474186005906 Acylphosphatases [Energy production and conversion]; Region: AcyP; COG1254 474186005907 OxaA-like protein precursor; Provisional; Region: PRK02463 474186005908 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 474186005909 hypothetical protein; Provisional; Region: PRK07758 474186005910 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 474186005911 DALR anticodon binding domain; Region: DALR_1; pfam05746 474186005912 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 474186005913 dimer interface [polypeptide binding]; other site 474186005914 motif 1; other site 474186005915 active site 474186005916 motif 2; other site 474186005917 motif 3; other site 474186005918 T-box leader; OG1RF_nc10030 474186005919 Recombination protein O N terminal; Region: RecO_N; pfam11967 474186005920 DNA repair protein RecO; Region: reco; TIGR00613 474186005921 Recombination protein O C terminal; Region: RecO_C; pfam02565 474186005922 GTPase Era; Reviewed; Region: era; PRK00089 474186005923 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 474186005924 G1 box; other site 474186005925 GTP/Mg2+ binding site [chemical binding]; other site 474186005926 Switch I region; other site 474186005927 G2 box; other site 474186005928 Switch II region; other site 474186005929 G3 box; other site 474186005930 G4 box; other site 474186005931 G5 box; other site 474186005932 KH domain; Region: KH_2; pfam07650 474186005933 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 474186005934 metal-binding heat shock protein; Provisional; Region: PRK00016 474186005935 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 474186005936 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 474186005937 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 474186005938 Zn2+ binding site [ion binding]; other site 474186005939 Mg2+ binding site [ion binding]; other site 474186005940 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 474186005941 PhoH-like protein; Region: PhoH; pfam02562 474186005942 Yqey-like protein; Region: YqeY; pfam09424 474186005943 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 474186005944 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 474186005945 metal binding site 2 [ion binding]; metal-binding site 474186005946 putative DNA binding helix; other site 474186005947 metal binding site 1 [ion binding]; metal-binding site 474186005948 dimer interface [polypeptide binding]; other site 474186005949 structural Zn2+ binding site [ion binding]; other site 474186005950 Kinase/pyrophosphorylase; Region: Kinase-PPPase; pfam03618 474186005951 homoserine kinase; Provisional; Region: PRK01212 474186005952 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 474186005953 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 474186005954 threonine synthase; Reviewed; Region: PRK06721 474186005955 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 474186005956 homodimer interface [polypeptide binding]; other site 474186005957 pyridoxal 5'-phosphate binding site [chemical binding]; other site 474186005958 catalytic residue [active] 474186005959 homoserine dehydrogenase; Provisional; Region: PRK06349 474186005960 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 474186005961 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 474186005962 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 474186005963 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 474186005964 dimerization interface [polypeptide binding]; other site 474186005965 putative DNA binding site [nucleotide binding]; other site 474186005966 putative Zn2+ binding site [ion binding]; other site 474186005967 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 474186005968 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 474186005969 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 474186005970 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 474186005971 active site 474186005972 substrate binding site [chemical binding]; other site 474186005973 metal binding site [ion binding]; metal-binding site 474186005974 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 474186005975 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 474186005976 DNA-binding site [nucleotide binding]; DNA binding site 474186005977 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 474186005978 pyridoxal 5'-phosphate binding site [chemical binding]; other site 474186005979 homodimer interface [polypeptide binding]; other site 474186005980 catalytic residue [active] 474186005981 Predicted transcriptional regulators [Transcription]; Region: COG1695 474186005982 Transcriptional regulator PadR-like family; Region: PadR; cl17335 474186005983 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 474186005984 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 474186005985 active site 474186005986 xanthine permease; Region: pbuX; TIGR03173 474186005987 Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303 474186005988 guanine deaminase; Region: guan_deamin; TIGR02967 474186005989 active site 474186005990 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 474186005991 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 474186005992 catalytic core [active] 474186005993 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 474186005994 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 474186005995 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 474186005996 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 474186005997 putative active site [active] 474186005998 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 474186005999 active site turn [active] 474186006000 phosphorylation site [posttranslational modification] 474186006001 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 474186006002 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 474186006003 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 474186006004 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 474186006005 putative active site [active] 474186006006 Uncharacterized conserved protein [Function unknown]; Region: COG3589 474186006007 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 474186006008 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 474186006009 HPr interaction site; other site 474186006010 glycerol kinase (GK) interaction site [polypeptide binding]; other site 474186006011 active site 474186006012 phosphorylation site [posttranslational modification] 474186006013 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 474186006014 uncharacterized YdjC-like family proteins from bacteria; Region: YdjC_like_1; cd10805 474186006015 putative active site [active] 474186006016 YdjC motif; other site 474186006017 Mg binding site [ion binding]; other site 474186006018 putative homodimer interface [polypeptide binding]; other site 474186006019 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 474186006020 Phosphate transporter family; Region: PHO4; pfam01384 474186006021 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 474186006022 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 474186006023 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 474186006024 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 474186006025 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 474186006026 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 474186006027 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 474186006028 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 474186006029 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 474186006030 Competence protein; Region: Competence; pfam03772 474186006031 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 474186006032 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 474186006033 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 474186006034 catalytic motif [active] 474186006035 Zn binding site [ion binding]; other site 474186006036 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 474186006037 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 474186006038 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 474186006039 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 474186006040 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 474186006041 protein binding site [polypeptide binding]; other site 474186006042 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 474186006043 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 474186006044 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 474186006045 active site 474186006046 (T/H)XGH motif; other site 474186006047 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 474186006048 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 474186006049 S-adenosylmethionine binding site [chemical binding]; other site 474186006050 Uncharacterized protein conserved in bacteria (DUF2129); Region: DUF2129; pfam09902 474186006051 Protein of unknown function (DUF964); Region: DUF964; pfam06133 474186006052 pyruvate carboxylase; Reviewed; Region: PRK12999 474186006053 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 474186006054 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 474186006055 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 474186006056 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 474186006057 active site 474186006058 catalytic residues [active] 474186006059 metal binding site [ion binding]; metal-binding site 474186006060 homodimer binding site [polypeptide binding]; other site 474186006061 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 474186006062 carboxyltransferase (CT) interaction site; other site 474186006063 biotinylation site [posttranslational modification]; other site 474186006064 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 474186006065 hypothetical protein; Provisional; Region: PRK13666 474186006066 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 474186006067 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 474186006068 ATP binding site [chemical binding]; other site 474186006069 putative Mg++ binding site [ion binding]; other site 474186006070 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 474186006071 nucleotide binding region [chemical binding]; other site 474186006072 ATP-binding site [chemical binding]; other site 474186006073 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 474186006074 HRDC domain; Region: HRDC; pfam00570 474186006075 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 474186006076 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 474186006077 G1 box; other site 474186006078 putative GEF interaction site [polypeptide binding]; other site 474186006079 GTP/Mg2+ binding site [chemical binding]; other site 474186006080 Switch I region; other site 474186006081 G2 box; other site 474186006082 G3 box; other site 474186006083 Switch II region; other site 474186006084 G4 box; other site 474186006085 G5 box; other site 474186006086 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 474186006087 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 474186006088 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 474186006089 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 474186006090 active site 474186006091 hypothetical protein; Provisional; Region: PRK04387 474186006092 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 474186006093 ClC sycA-like chloride channel proteins. This ClC family presents in bacteria, where it facilitates acid resistance in acidic soil. Mutation of this gene (sycA) in Rhizobium tropici CIAT899 causes serious deficiencies in nodule development, nodulation...; Region: ClC_sycA_like; cd03682 474186006094 putative Cl- selectivity filter; other site 474186006095 putative pore gating glutamate residue; other site 474186006096 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 474186006097 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 474186006098 active site 474186006099 Cna protein B-type domain; Region: Cna_B; pfam05738 474186006100 Cna protein B-type domain; Region: Cna_B; pfam05738 474186006101 Cna protein B-type domain; Region: Cna_B; pfam05738 474186006102 Cna protein B-type domain; Region: Cna_B; pfam05738 474186006103 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 474186006104 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 474186006105 non-specific DNA binding site [nucleotide binding]; other site 474186006106 salt bridge; other site 474186006107 sequence-specific DNA binding site [nucleotide binding]; other site 474186006108 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 474186006109 Zn2+ binding site [ion binding]; other site 474186006110 Mg2+ binding site [ion binding]; other site 474186006111 arginyl-tRNA synthetase; Reviewed; Region: PRK12451 474186006112 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 474186006113 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 474186006114 active site 474186006115 HIGH motif; other site 474186006116 KMSK motif region; other site 474186006117 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 474186006118 tRNA binding surface [nucleotide binding]; other site 474186006119 anticodon binding site; other site 474186006120 T-box leader; OG1RF_nc10031 474186006121 UGMP family protein; Validated; Region: PRK09604 474186006122 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 474186006123 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 474186006124 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 474186006125 Coenzyme A binding pocket [chemical binding]; other site 474186006126 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 474186006127 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 474186006128 Coenzyme A binding pocket [chemical binding]; other site 474186006129 Glycoprotease family; Region: Peptidase_M22; pfam00814 474186006130 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 474186006131 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 474186006132 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 474186006133 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 474186006134 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 474186006135 Membrane protease subunit, stomatin/prohibitin family [Amino acid transport and metabolism]; Region: COG4260 474186006136 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_5; cd03408 474186006137 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 474186006138 Uncharacterized protein family UPF0547; Region: UPF0547; pfam10571 474186006139 Repair protein; Region: Repair_PSII; pfam04536 474186006140 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 474186006141 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 474186006142 motif II; other site 474186006143 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_IV; cd01994 474186006144 Ligand Binding Site [chemical binding]; other site 474186006145 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 474186006146 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 474186006147 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 474186006148 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 474186006149 catalytic residue [active] 474186006150 putative FPP diphosphate binding site; other site 474186006151 putative FPP binding hydrophobic cleft; other site 474186006152 dimer interface [polypeptide binding]; other site 474186006153 putative IPP diphosphate binding site; other site 474186006154 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 474186006155 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 474186006156 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 474186006157 dimer interface [polypeptide binding]; other site 474186006158 conserved gate region; other site 474186006159 ABC-ATPase subunit interface; other site 474186006160 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 474186006161 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 474186006162 Walker A/P-loop; other site 474186006163 ATP binding site [chemical binding]; other site 474186006164 Q-loop/lid; other site 474186006165 ABC transporter signature motif; other site 474186006166 Walker B; other site 474186006167 D-loop; other site 474186006168 H-loop/switch region; other site 474186006169 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 474186006170 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 474186006171 lipoyl attachment site [posttranslational modification]; other site 474186006172 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 474186006173 ArsC family; Region: ArsC; pfam03960 474186006174 putative ArsC-like catalytic residues; other site 474186006175 putative TRX-like catalytic residues [active] 474186006176 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 474186006177 Mga helix-turn-helix domain; Region: Mga; pfam05043 474186006178 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 474186006179 Cna protein B-type domain; Region: Cna_B; pfam05738 474186006180 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 474186006181 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 474186006182 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 474186006183 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 474186006184 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 474186006185 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 474186006186 non-specific DNA binding site [nucleotide binding]; other site 474186006187 salt bridge; other site 474186006188 sequence-specific DNA binding site [nucleotide binding]; other site 474186006189 Cupin domain; Region: Cupin_2; pfam07883 474186006190 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 474186006191 Predicted membrane protein [Function unknown]; Region: COG4392 474186006192 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 474186006193 active site 474186006194 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 474186006195 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 474186006196 dimer interface [polypeptide binding]; other site 474186006197 active site 474186006198 glycine-pyridoxal phosphate binding site [chemical binding]; other site 474186006199 folate binding site [chemical binding]; other site 474186006200 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 474186006201 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 474186006202 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 474186006203 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 474186006204 S-adenosylmethionine binding site [chemical binding]; other site 474186006205 peptide chain release factor 1; Validated; Region: prfA; PRK00591 474186006206 This domain is found in peptide chain release factors; Region: PCRF; smart00937 474186006207 RF-1 domain; Region: RF-1; pfam00472 474186006208 thymidine kinase; Provisional; Region: PRK04296 474186006209 fumarate reductase flavoprotein subunit; Validated; Region: PRK06481 474186006210 L-aspartate oxidase; Provisional; Region: PRK06175 474186006211 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 474186006212 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 474186006213 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 474186006214 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 474186006215 dimer interface [polypeptide binding]; other site 474186006216 PYR/PP interface [polypeptide binding]; other site 474186006217 TPP binding site [chemical binding]; other site 474186006218 substrate binding site [chemical binding]; other site 474186006219 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 474186006220 Domain of unknown function; Region: EKR; smart00890 474186006221 4Fe-4S binding domain; Region: Fer4_6; pfam12837 474186006222 4Fe-4S binding domain; Region: Fer4; pfam00037 474186006223 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 474186006224 TPP-binding site [chemical binding]; other site 474186006225 dimer interface [polypeptide binding]; other site 474186006226 putative oxidoreductase; Provisional; Region: PRK12831 474186006227 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 474186006228 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 474186006229 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 474186006230 ferredoxin-NADP(+) reductase subunit alpha; Reviewed; Region: PRK06222 474186006231 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)...; Region: DHOD_e_trans_like1; cd06219 474186006232 FAD binding pocket [chemical binding]; other site 474186006233 FAD binding motif [chemical binding]; other site 474186006234 phosphate binding motif [ion binding]; other site 474186006235 beta-alpha-beta structure motif; other site 474186006236 NAD binding pocket [chemical binding]; other site 474186006237 Iron coordination center [ion binding]; other site 474186006238 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 474186006239 selenium-dependent molybdenum hydroxylase system protein, YqeB family; Region: matur_yqeB; TIGR03309 474186006240 probable selenium-dependent hydroxylase accessory protein YqeC; Region: TIGR03172 474186006241 Protein of unknown function (DUF3343); Region: DUF3343; pfam11823 474186006242 selenium metabolism protein YedF; Region: selenium_YedF; TIGR03527 474186006243 SirA_like_N, a protein of unknown function with an N-terminal SirA-like domain. The SirA, YedF, YeeD protein family is present in bacteria as well as archaea. SirA (also known as UvrY, and YhhP) belongs to a family of a two-component response...; Region: SirA_like_N; cd03421 474186006244 CPxP motif; other site 474186006245 DsrE/DsrF-like family; Region: DrsE; cl00672 474186006246 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 474186006247 selenophosphate synthetase; Provisional; Region: PRK00943 474186006248 dimerization interface [polypeptide binding]; other site 474186006249 putative ATP binding site [chemical binding]; other site 474186006250 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 474186006251 cysteine desulfurase family protein; Region: am_tr_V_EF2568; TIGR01977 474186006252 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 474186006253 catalytic residue [active] 474186006254 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 474186006255 Ligand binding site; other site 474186006256 metal-binding site 474186006257 selenium-dependent molybdenum hydroxylase 1; Region: Se_dep_Molyb_1; TIGR03311 474186006258 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 474186006259 catalytic loop [active] 474186006260 iron binding site [ion binding]; other site 474186006261 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 474186006262 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 474186006263 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 474186006264 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 474186006265 xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964 474186006266 XdhC Rossmann domain; Region: XdhC_C; pfam13478 474186006267 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 474186006268 xanthine permease; Region: pbuX; TIGR03173 474186006269 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 474186006270 homotrimer interaction site [polypeptide binding]; other site 474186006271 putative active site [active] 474186006272 carbamate kinase; Reviewed; Region: PRK12686 474186006273 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 474186006274 putative substrate binding site [chemical binding]; other site 474186006275 nucleotide binding site [chemical binding]; other site 474186006276 nucleotide binding site [chemical binding]; other site 474186006277 homodimer interface [polypeptide binding]; other site 474186006278 aspartate/ornithine carbamoyltransferase family protein; Validated; Region: PRK07200 474186006279 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 474186006280 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 474186006281 putative selenium metabolism hydrolase; Region: selenium_YgeY; TIGR03526 474186006282 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like4; cd05649 474186006283 putative metal binding site [ion binding]; other site 474186006284 putative dimer interface [polypeptide binding]; other site 474186006285 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cd00640 474186006286 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 474186006287 catalytic residue [active] 474186006288 D-hydantoinase; Region: D-hydantoinase; TIGR02033 474186006289 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 474186006290 tetramer interface [polypeptide binding]; other site 474186006291 active site 474186006292 putative selenate reductase, YgfK subunit; Region: Se_ygfK; TIGR03315 474186006293 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 474186006294 putative chlorohydrolase/aminohydrolase; Validated; Region: PRK07203 474186006295 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 474186006296 active site 474186006297 putative substrate binding pocket [chemical binding]; other site 474186006298 YheO-like PAS domain; Region: PAS_6; pfam08348 474186006299 HTH domain; Region: HTH_22; pfam13309 474186006300 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 474186006301 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 474186006302 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 474186006303 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 474186006304 catalytic triad [active] 474186006305 NH_3: A subgroup of nucleoside hydrolases. This group contains eukaryotic and bacterial proteins similar to nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes...; Region: nuc_hydro_3; cd02653 474186006306 active site 474186006307 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 474186006308 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 474186006309 Beta-lactamase; Region: Beta-lactamase; pfam00144 474186006310 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 474186006311 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 474186006312 active site 474186006313 metal binding site [ion binding]; metal-binding site 474186006314 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 474186006315 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 474186006316 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 474186006317 Walker A/P-loop; other site 474186006318 ATP binding site [chemical binding]; other site 474186006319 Q-loop/lid; other site 474186006320 ABC transporter signature motif; other site 474186006321 Walker B; other site 474186006322 D-loop; other site 474186006323 H-loop/switch region; other site 474186006324 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 474186006325 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 474186006326 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 474186006327 Walker A/P-loop; other site 474186006328 ATP binding site [chemical binding]; other site 474186006329 Q-loop/lid; other site 474186006330 ABC transporter signature motif; other site 474186006331 Walker B; other site 474186006332 D-loop; other site 474186006333 H-loop/switch region; other site 474186006334 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 474186006335 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 474186006336 Guanylate kinase; Region: Guanylate_kin; pfam00625 474186006337 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 474186006338 catalytic site [active] 474186006339 G-X2-G-X-G-K; other site 474186006340 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 474186006341 beta-galactosidase; Region: BGL; TIGR03356 474186006342 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 474186006343 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 474186006344 active site turn [active] 474186006345 phosphorylation site [posttranslational modification] 474186006346 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 474186006347 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 474186006348 HPr interaction site; other site 474186006349 glycerol kinase (GK) interaction site [polypeptide binding]; other site 474186006350 active site 474186006351 phosphorylation site [posttranslational modification] 474186006352 transcriptional antiterminator BglG; Provisional; Region: PRK09772 474186006353 CAT RNA binding domain; Region: CAT_RBD; smart01061 474186006354 PRD domain; Region: PRD; pfam00874 474186006355 PRD domain; Region: PRD; pfam00874 474186006356 Acyl carrier protein phosphodiesterase [Lipid metabolism]; Region: AcpD; COG1182 474186006357 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 474186006358 Domain of unknown function DUF20; Region: UPF0118; pfam01594 474186006359 PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; cl01516 474186006360 DNA-directed RNA polymerase subunit beta; Region: EpuA; pfam11772 474186006361 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 474186006362 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 474186006363 hinge; other site 474186006364 active site 474186006365 conserved hypothetical integral membrane protein; Region: int_mem_ywzB; TIGR02327 474186006366 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 474186006367 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 474186006368 gamma subunit interface [polypeptide binding]; other site 474186006369 epsilon subunit interface [polypeptide binding]; other site 474186006370 LBP interface [polypeptide binding]; other site 474186006371 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 474186006372 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 474186006373 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 474186006374 alpha subunit interaction interface [polypeptide binding]; other site 474186006375 Walker A motif; other site 474186006376 ATP binding site [chemical binding]; other site 474186006377 Walker B motif; other site 474186006378 inhibitor binding site; inhibition site 474186006379 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 474186006380 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 474186006381 core domain interface [polypeptide binding]; other site 474186006382 delta subunit interface [polypeptide binding]; other site 474186006383 epsilon subunit interface [polypeptide binding]; other site 474186006384 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 474186006385 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 474186006386 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 474186006387 beta subunit interaction interface [polypeptide binding]; other site 474186006388 Walker A motif; other site 474186006389 ATP binding site [chemical binding]; other site 474186006390 Walker B motif; other site 474186006391 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 474186006392 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 474186006393 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 474186006394 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 474186006395 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 474186006396 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 474186006397 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 474186006398 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 474186006399 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 474186006400 SmpB-tmRNA interface; other site 474186006401 ribonuclease R; Region: RNase_R; TIGR02063 474186006402 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 474186006403 RNB domain; Region: RNB; pfam00773 474186006404 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 474186006405 RNA binding site [nucleotide binding]; other site 474186006406 Esterase/lipase [General function prediction only]; Region: COG1647 474186006407 Preprotein translocase SecG subunit; Region: SecG; pfam03840 474186006408 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 474186006409 Coenzyme A binding pocket [chemical binding]; other site 474186006410 Uncharacterized conserved protein [Function unknown]; Region: COG3592 474186006411 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 474186006412 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 474186006413 Soluble P-type ATPase [General function prediction only]; Region: COG4087 474186006414 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 474186006415 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 474186006416 homodimer interface [polypeptide binding]; other site 474186006417 NAD binding pocket [chemical binding]; other site 474186006418 ATP binding pocket [chemical binding]; other site 474186006419 Mg binding site [ion binding]; other site 474186006420 active-site loop [active] 474186006421 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 474186006422 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 474186006423 active site 474186006424 Predicted membrane protein [Function unknown]; Region: COG2246 474186006425 GtrA-like protein; Region: GtrA; pfam04138 474186006426 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 474186006427 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 474186006428 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 474186006429 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 474186006430 ribonuclease Y; Region: RNase_Y; TIGR03319 474186006431 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 474186006432 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 474186006433 DNA binding site [nucleotide binding] 474186006434 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 474186006435 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 474186006436 ring oligomerisation interface [polypeptide binding]; other site 474186006437 ATP/Mg binding site [chemical binding]; other site 474186006438 stacking interactions; other site 474186006439 hinge regions; other site 474186006440 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 474186006441 oligomerisation interface [polypeptide binding]; other site 474186006442 mobile loop; other site 474186006443 roof hairpin; other site 474186006444 CAAX protease self-immunity; Region: Abi; pfam02517 474186006445 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 474186006446 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 474186006447 CoA binding domain; Region: CoA_binding; pfam02629 474186006448 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 474186006449 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 474186006450 Walker A/P-loop; other site 474186006451 ATP binding site [chemical binding]; other site 474186006452 Q-loop/lid; other site 474186006453 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 474186006454 ABC transporter signature motif; other site 474186006455 Walker B; other site 474186006456 D-loop; other site 474186006457 H-loop/switch region; other site 474186006458 ABC transporter; Region: ABC_tran_2; pfam12848 474186006459 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 474186006460 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 474186006461 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 474186006462 DNA-binding site [nucleotide binding]; DNA binding site 474186006463 TrkA-C domain; Region: TrkA_C; pfam02080 474186006464 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 474186006465 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 474186006466 Walker A/P-loop; other site 474186006467 ATP binding site [chemical binding]; other site 474186006468 Q-loop/lid; other site 474186006469 ABC transporter signature motif; other site 474186006470 Walker B; other site 474186006471 D-loop; other site 474186006472 H-loop/switch region; other site 474186006473 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 474186006474 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 474186006475 dimer interface [polypeptide binding]; other site 474186006476 conserved gate region; other site 474186006477 putative PBP binding loops; other site 474186006478 ABC-ATPase subunit interface; other site 474186006479 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 474186006480 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 474186006481 Uncharacterized protein/domain associated with GTPases [Function unknown]; Region: COG3597 474186006482 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 474186006483 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 474186006484 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 474186006485 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 474186006486 glycerate kinase; Region: TIGR00045 474186006487 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 474186006488 fructuronate transporter; Provisional; Region: PRK10034; cl15264 474186006489 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 474186006490 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 474186006491 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 474186006492 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 474186006493 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 474186006494 dimer interface [polypeptide binding]; other site 474186006495 conserved gate region; other site 474186006496 putative PBP binding loops; other site 474186006497 ABC-ATPase subunit interface; other site 474186006498 2-aminoethylphosphonate transport system permease PhnU; Provisional; Region: PRK15050 474186006499 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 474186006500 dimer interface [polypeptide binding]; other site 474186006501 conserved gate region; other site 474186006502 putative PBP binding loops; other site 474186006503 ABC-ATPase subunit interface; other site 474186006504 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 474186006505 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 474186006506 Walker A/P-loop; other site 474186006507 ATP binding site [chemical binding]; other site 474186006508 Q-loop/lid; other site 474186006509 ABC transporter signature motif; other site 474186006510 Walker B; other site 474186006511 D-loop; other site 474186006512 H-loop/switch region; other site 474186006513 TOBE domain; Region: TOBE_2; pfam08402 474186006514 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 474186006515 non-specific DNA binding site [nucleotide binding]; other site 474186006516 salt bridge; other site 474186006517 sequence-specific DNA binding site [nucleotide binding]; other site 474186006518 Cupin domain; Region: Cupin_2; pfam07883 474186006519 Yhdh and yhfp-like putative quinone oxidoreductases; Region: MDR_yhdh_yhfp; cd05280 474186006520 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 474186006521 NADP binding site [chemical binding]; other site 474186006522 dimer interface [polypeptide binding]; other site 474186006523 phosphopantothenate--cysteine ligase, streptococcal; Region: coaB_strep; TIGR02114 474186006524 phosphopantothenoylcysteine decarboxylase, streptococcal; Region: coaC_strep; TIGR02113 474186006525 Flavoprotein; Region: Flavoprotein; pfam02441 474186006526 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 474186006527 Predicted membrane protein [Function unknown]; Region: COG4684 474186006528 FemAB family; Region: FemAB; pfam02388 474186006529 QueT transporter; Region: QueT; pfam06177 474186006530 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 474186006531 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 474186006532 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 474186006533 AAA domain; Region: AAA_30; pfam13604 474186006534 Family description; Region: UvrD_C_2; pfam13538 474186006535 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 474186006536 catalytic core [active] 474186006537 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 474186006538 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 474186006539 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 474186006540 S-adenosylmethionine binding site [chemical binding]; other site 474186006541 Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142 474186006542 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 474186006543 MgtE intracellular N domain; Region: MgtE_N; pfam03448 474186006544 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 474186006545 Divalent cation transporter; Region: MgtE; pfam01769 474186006546 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 474186006547 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 474186006548 active site 474186006549 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 474186006550 ATP-NAD kinase; Region: NAD_kinase; pfam01513 474186006551 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 474186006552 synthetase active site [active] 474186006553 NTP binding site [chemical binding]; other site 474186006554 metal binding site [ion binding]; metal-binding site 474186006555 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 474186006556 putative active site [active] 474186006557 putative metal binding residues [ion binding]; other site 474186006558 signature motif; other site 474186006559 putative triphosphate binding site [ion binding]; other site 474186006560 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 474186006561 catalytic residues [active] 474186006562 Oligoendopeptidase F [Amino acid transport and metabolism]; Region: COG1164 474186006563 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 474186006564 active site 474186006565 Zn binding site [ion binding]; other site 474186006566 Competence protein CoiA-like family; Region: CoiA; pfam06054 474186006567 adaptor protein; Provisional; Region: PRK02315 474186006568 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 474186006569 ArsC family; Region: ArsC; pfam03960 474186006570 putative catalytic residues [active] 474186006571 thiol/disulfide switch; other site 474186006572 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 474186006573 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 474186006574 active site 474186006575 HIGH motif; other site 474186006576 dimer interface [polypeptide binding]; other site 474186006577 KMSKS motif; other site 474186006578 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 474186006579 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 474186006580 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 474186006581 Walker A/P-loop; other site 474186006582 ATP binding site [chemical binding]; other site 474186006583 Q-loop/lid; other site 474186006584 ABC transporter signature motif; other site 474186006585 Walker B; other site 474186006586 D-loop; other site 474186006587 H-loop/switch region; other site 474186006588 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 474186006589 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 474186006590 motif II; other site 474186006591 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 474186006592 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 474186006593 WxL domain surface cell wall-binding; Region: WxL; pfam13731 474186006594 WxL domain surface cell wall-binding; Region: WxL; pfam13731 474186006595 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 474186006596 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 474186006597 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 474186006598 Leucine-rich repeats; other site 474186006599 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 474186006600 Substrate binding site [chemical binding]; other site 474186006601 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 474186006602 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 474186006603 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 474186006604 LRR adjacent; Region: LRR_adjacent; pfam08191 474186006605 WxL domain surface cell wall-binding; Region: WxL; pfam13731 474186006606 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 474186006607 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 474186006608 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 474186006609 ATP binding site [chemical binding]; other site 474186006610 putative Mg++ binding site [ion binding]; other site 474186006611 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 474186006612 nucleotide binding region [chemical binding]; other site 474186006613 ATP-binding site [chemical binding]; other site 474186006614 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 474186006615 AAA domain; Region: AAA_23; pfam13476 474186006616 Walker A/P-loop; other site 474186006617 ATP binding site [chemical binding]; other site 474186006618 Q-loop/lid; other site 474186006619 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 474186006620 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 474186006621 ABC transporter signature motif; other site 474186006622 Walker B; other site 474186006623 D-loop; other site 474186006624 H-loop/switch region; other site 474186006625 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 474186006626 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 474186006627 active site 474186006628 metal binding site [ion binding]; metal-binding site 474186006629 DNA binding site [nucleotide binding] 474186006630 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 474186006631 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 474186006632 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 474186006633 putative acyl-acceptor binding pocket; other site 474186006634 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 474186006635 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 474186006636 S-adenosylmethionine binding site [chemical binding]; other site 474186006637 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 474186006638 GIY-YIG motif/motif A; other site 474186006639 putative active site [active] 474186006640 putative metal binding site [ion binding]; other site 474186006641 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 474186006642 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 474186006643 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 474186006644 dimer interface [polypeptide binding]; other site 474186006645 ADP-ribose binding site [chemical binding]; other site 474186006646 active site 474186006647 nudix motif; other site 474186006648 metal binding site [ion binding]; metal-binding site 474186006649 5-bromo-4-chloroindolyl phosphate hydrolysis protein; Region: Halogen_Hydrol; pfam10112 474186006650 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 474186006651 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 474186006652 nudix motif; other site 474186006653 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 474186006654 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 474186006655 Coenzyme A binding pocket [chemical binding]; other site 474186006656 Transcriptional regulator [Transcription]; Region: LytR; COG1316 474186006657 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 474186006658 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 474186006659 minor groove reading motif; other site 474186006660 helix-hairpin-helix signature motif; other site 474186006661 substrate binding pocket [chemical binding]; other site 474186006662 active site 474186006663 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 474186006664 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 474186006665 DNA binding and oxoG recognition site [nucleotide binding] 474186006666 recombination regulator RecX; Provisional; Region: recX; PRK14135 474186006667 TRAM domain; Region: TRAM; pfam01938 474186006668 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 474186006669 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 474186006670 S-adenosylmethionine binding site [chemical binding]; other site 474186006671 Predicted membrane protein [Function unknown]; Region: COG2261 474186006672 cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340 474186006673 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 474186006674 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 474186006675 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 474186006676 Beta galactosidase small chain; Region: Bgal_small_N; smart01038 474186006677 Amino acid permease; Region: AA_permease_2; pfam13520 474186006678 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 474186006679 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 474186006680 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 474186006681 Glucosyl transferase GtrII; Region: Glucos_trans_II; pfam14264 474186006682 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 474186006683 core dimer interface [polypeptide binding]; other site 474186006684 peripheral dimer interface [polypeptide binding]; other site 474186006685 L10 interface [polypeptide binding]; other site 474186006686 L11 interface [polypeptide binding]; other site 474186006687 putative EF-Tu interaction site [polypeptide binding]; other site 474186006688 putative EF-G interaction site [polypeptide binding]; other site 474186006689 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 474186006690 23S rRNA interface [nucleotide binding]; other site 474186006691 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 474186006692 Ribosomal protein L10 leader; OG1RF_nc10034 474186006693 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 474186006694 mRNA/rRNA interface [nucleotide binding]; other site 474186006695 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 474186006696 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 474186006697 23S rRNA interface [nucleotide binding]; other site 474186006698 L7/L12 interface [polypeptide binding]; other site 474186006699 putative thiostrepton binding site; other site 474186006700 L25 interface [polypeptide binding]; other site 474186006701 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 474186006702 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 474186006703 ABC transporter; Region: ABC_tran_2; pfam12848 474186006704 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 474186006705 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 474186006706 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 474186006707 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 474186006708 putative L-serine binding site [chemical binding]; other site 474186006709 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 474186006710 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 474186006711 Peptidase M55, D-aminopeptidase dipeptide-binding protein family; Region: DAP_dppA_2; cd08769 474186006712 SxDxEG motif; other site 474186006713 putative active site [active] 474186006714 putative metal binding site [ion binding]; other site 474186006715 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 474186006716 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 474186006717 oligomer interface [polypeptide binding]; other site 474186006718 active site 474186006719 metal binding site [ion binding]; metal-binding site 474186006720 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 474186006721 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 474186006722 peptide binding site [polypeptide binding]; other site 474186006723 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 474186006724 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 474186006725 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 474186006726 putative active site [active] 474186006727 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 474186006728 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 474186006729 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 474186006730 putative homodimer interface [polypeptide binding]; other site 474186006731 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 474186006732 heterodimer interface [polypeptide binding]; other site 474186006733 homodimer interface [polypeptide binding]; other site 474186006734 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 474186006735 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 474186006736 FOG: CBS domain [General function prediction only]; Region: COG0517 474186006737 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 474186006738 conserved hypothetical integral membrane protein; Region: TIGR03766 474186006739 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 474186006740 FAD binding domain; Region: FAD_binding_4; pfam01565 474186006741 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 474186006742 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 474186006743 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 474186006744 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 474186006745 active site 474186006746 putative catalytic site [active] 474186006747 DNA binding site [nucleotide binding] 474186006748 putative phosphate binding site [ion binding]; other site 474186006749 metal binding site A [ion binding]; metal-binding site 474186006750 AP binding site [nucleotide binding]; other site 474186006751 metal binding site B [ion binding]; metal-binding site 474186006752 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 474186006753 active site 474186006754 catalytic site [active] 474186006755 substrate binding site [chemical binding]; other site 474186006756 putative alkyl hydroperoxide reductase F subunit; Region: AhpF_homolog; TIGR03143 474186006757 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 474186006758 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 474186006759 catalytic residue [active] 474186006760 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 474186006761 catalytic residues [active] 474186006762 peroxiredoxin; Region: AhpC; TIGR03137 474186006763 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 474186006764 dimer interface [polypeptide binding]; other site 474186006765 decamer (pentamer of dimers) interface [polypeptide binding]; other site 474186006766 catalytic triad [active] 474186006767 peroxidatic and resolving cysteines [active] 474186006768 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 474186006769 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 474186006770 S-adenosylmethionine binding site [chemical binding]; other site 474186006771 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 474186006772 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 474186006773 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 474186006774 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 474186006775 Protein of unknown function (DUF975); Region: DUF975; cl10504 474186006776 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 474186006777 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 474186006778 oligomer interface [polypeptide binding]; other site 474186006779 active site 474186006780 metal binding site [ion binding]; metal-binding site 474186006781 D-alanyl-lipoteichoic acid biosynthesis protein DltD; Region: LTA_DltD; TIGR04092 474186006782 DltD N-terminal region; Region: DltD_N; pfam04915 474186006783 DltD central region; Region: DltD_M; pfam04918 474186006784 DltD C-terminal region; Region: DltD_C; pfam04914 474186006785 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087 474186006786 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091 474186006787 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 474186006788 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 474186006789 acyl-activating enzyme (AAE) consensus motif; other site 474186006790 AMP binding site [chemical binding]; other site 474186006791 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 474186006792 FtsX-like permease family; Region: FtsX; pfam02687 474186006793 FtsX-like permease family; Region: FtsX; pfam02687 474186006794 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 474186006795 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 474186006796 Walker A/P-loop; other site 474186006797 ATP binding site [chemical binding]; other site 474186006798 Q-loop/lid; other site 474186006799 ABC transporter signature motif; other site 474186006800 Walker B; other site 474186006801 D-loop; other site 474186006802 H-loop/switch region; other site 474186006803 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 474186006804 ATP cone domain; Region: ATP-cone; pfam03477 474186006805 Class III ribonucleotide reductase; Region: RNR_III; cd01675 474186006806 effector binding site; other site 474186006807 active site 474186006808 Zn binding site [ion binding]; other site 474186006809 glycine loop; other site 474186006810 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804 474186006811 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 474186006812 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 474186006813 active site 474186006814 DNA polymerase IV; Validated; Region: PRK02406 474186006815 DNA binding site [nucleotide binding] 474186006816 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 474186006817 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 474186006818 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 474186006819 Walker A/P-loop; other site 474186006820 ATP binding site [chemical binding]; other site 474186006821 Q-loop/lid; other site 474186006822 ABC transporter signature motif; other site 474186006823 Walker B; other site 474186006824 D-loop; other site 474186006825 H-loop/switch region; other site 474186006826 Predicted methyltransferases [General function prediction only]; Region: COG0313 474186006827 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 474186006828 putative SAM binding site [chemical binding]; other site 474186006829 putative homodimer interface [polypeptide binding]; other site 474186006830 Protein of unknown function (DUF972); Region: DUF972; pfam06156 474186006831 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 474186006832 DNA polymerase III subunit delta'; Validated; Region: PRK08058 474186006833 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 474186006834 Walker A motif; other site 474186006835 ATP binding site [chemical binding]; other site 474186006836 Walker B motif; other site 474186006837 arginine finger; other site 474186006838 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3870 474186006839 thymidylate kinase; Validated; Region: tmk; PRK00698 474186006840 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 474186006841 TMP-binding site; other site 474186006842 ATP-binding site [chemical binding]; other site 474186006843 recombination protein RecR; Reviewed; Region: recR; PRK00076 474186006844 RecR protein; Region: RecR; pfam02132 474186006845 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 474186006846 putative active site [active] 474186006847 putative metal-binding site [ion binding]; other site 474186006848 tetramer interface [polypeptide binding]; other site 474186006849 Putative transcription activator [Transcription]; Region: TenA; COG0819 474186006850 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 474186006851 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 474186006852 Walker A/P-loop; other site 474186006853 ATP binding site [chemical binding]; other site 474186006854 Q-loop/lid; other site 474186006855 ABC transporter signature motif; other site 474186006856 Walker B; other site 474186006857 D-loop; other site 474186006858 H-loop/switch region; other site 474186006859 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4136 474186006860 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 474186006861 Walker A/P-loop; other site 474186006862 ATP binding site [chemical binding]; other site 474186006863 Q-loop/lid; other site 474186006864 ABC transporter signature motif; other site 474186006865 Walker B; other site 474186006866 D-loop; other site 474186006867 H-loop/switch region; other site 474186006868 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; cl01943 474186006869 TraX protein; Region: TraX; cl05434 474186006870 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 474186006871 Major Facilitator Superfamily; Region: MFS_1; pfam07690 474186006872 putative substrate translocation pore; other site 474186006873 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 474186006874 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 474186006875 putative substrate translocation pore; other site 474186006876 Predicted transcriptional regulators [Transcription]; Region: COG1733 474186006877 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 474186006878 putative DNA binding site [nucleotide binding]; other site 474186006879 putative Zn2+ binding site [ion binding]; other site 474186006880 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 474186006881 dimer interface [polypeptide binding]; other site 474186006882 substrate binding site [chemical binding]; other site 474186006883 ATP binding site [chemical binding]; other site 474186006884 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 474186006885 thiamine phosphate binding site [chemical binding]; other site 474186006886 active site 474186006887 pyrophosphate binding site [ion binding]; other site 474186006888 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 474186006889 substrate binding site [chemical binding]; other site 474186006890 multimerization interface [polypeptide binding]; other site 474186006891 ATP binding site [chemical binding]; other site 474186006892 thiW protein; Region: thiW; TIGR02359 474186006893 hypothetical protein; Validated; Region: PRK00153 474186006894 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 474186006895 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 474186006896 Walker A motif; other site 474186006897 ATP binding site [chemical binding]; other site 474186006898 Walker B motif; other site 474186006899 arginine finger; other site 474186006900 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 474186006901 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 474186006902 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 474186006903 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 474186006904 NAD binding site [chemical binding]; other site 474186006905 homodimer interface [polypeptide binding]; other site 474186006906 active site 474186006907 substrate binding site [chemical binding]; other site 474186006908 Protein of unknown function (DUF3042); Region: DUF3042; pfam11240 474186006909 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 474186006910 Uncharacterized conserved protein [Function unknown]; Region: COG3189 474186006911 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 474186006912 active site residue [active] 474186006913 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 474186006914 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 474186006915 nucleotide binding site [chemical binding]; other site 474186006916 Bacterial protein of unknown function (DUF910); Region: DUF910; pfam06014 474186006917 Rhomboid family; Region: Rhomboid; pfam01694 474186006918 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 474186006919 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 474186006920 esterase; Provisional; Region: PRK10566 474186006921 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 474186006922 Protein of unknown function (DUF805); Region: DUF805; pfam05656 474186006923 conserved hypothetical integral membrane protein; Region: TIGR03766 474186006924 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 474186006925 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 474186006926 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 474186006927 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 474186006928 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 474186006929 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 474186006930 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 474186006931 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 474186006932 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 474186006933 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 474186006934 active site 474186006935 dimer interface [polypeptide binding]; other site 474186006936 motif 1; other site 474186006937 motif 2; other site 474186006938 motif 3; other site 474186006939 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 474186006940 anticodon binding site; other site 474186006941 4-oxalocrotonate tautomerase; Provisional; Region: PRK02220 474186006942 active site 1 [active] 474186006943 dimer interface [polypeptide binding]; other site 474186006944 hexamer interface [polypeptide binding]; other site 474186006945 active site 2 [active] 474186006946 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 474186006947 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 474186006948 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 474186006949 dimer interface [polypeptide binding]; other site 474186006950 phosphorylation site [posttranslational modification] 474186006951 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 474186006952 ATP binding site [chemical binding]; other site 474186006953 Mg2+ binding site [ion binding]; other site 474186006954 G-X-G motif; other site 474186006955 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 474186006956 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 474186006957 active site 474186006958 phosphorylation site [posttranslational modification] 474186006959 intermolecular recognition site; other site 474186006960 dimerization interface [polypeptide binding]; other site 474186006961 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 474186006962 DNA binding site [nucleotide binding] 474186006963 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 474186006964 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 474186006965 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 474186006966 Streptomycin adenylyltransferase; Region: Adenyl_transf; pfam04439 474186006967 Uncharacterized conserved protein [Function unknown]; Region: COG1434 474186006968 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 474186006969 putative active site [active] 474186006970 Endo-beta-N-acetylglucosaminidases are bacterial chitinases that hydrolyze the chitin core of various asparagine (N)-linked glycans and glycoproteins. The endo-beta-N-acetylglucosaminidases have a glycosyl hydrolase family 18 (GH18) catalytic domain; Region: GH18_EndoS-like; cd06542 474186006971 active site 474186006972 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 474186006973 hypothetical protein; Provisional; Region: PRK12378 474186006974 hypothetical protein; Provisional; Region: PRK13670 474186006975 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673 474186006976 Methyltransferase domain; Region: Methyltransf_23; pfam13489 474186006977 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 474186006978 S-adenosylmethionine binding site [chemical binding]; other site 474186006979 Oligomerisation domain; Region: Oligomerisation; cl00519 474186006980 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 474186006981 Zn2+ binding site [ion binding]; other site 474186006982 Mg2+ binding site [ion binding]; other site 474186006983 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 474186006984 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 474186006985 active site 474186006986 (T/H)XGH motif; other site 474186006987 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 474186006988 GTPase YqeH; Provisional; Region: PRK13796 474186006989 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 474186006990 GTP/Mg2+ binding site [chemical binding]; other site 474186006991 G4 box; other site 474186006992 G5 box; other site 474186006993 G1 box; other site 474186006994 Switch I region; other site 474186006995 G2 box; other site 474186006996 G3 box; other site 474186006997 Switch II region; other site 474186006998 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 474186006999 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 474186007000 active site 474186007001 motif I; other site 474186007002 motif II; other site 474186007003 acetyl-CoA carboxylase subunit alpha; Provisional; Region: PRK12319 474186007004 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 474186007005 Uncharacterized protein family UPF0547; Region: UPF0547; pfam10571 474186007006 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 474186007007 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 474186007008 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 474186007009 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 474186007010 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 474186007011 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 474186007012 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 474186007013 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 474186007014 carboxyltransferase (CT) interaction site; other site 474186007015 biotinylation site [posttranslational modification]; other site 474186007016 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 474186007017 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 474186007018 dimer interface [polypeptide binding]; other site 474186007019 active site 474186007020 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 474186007021 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 474186007022 NAD(P) binding site [chemical binding]; other site 474186007023 homotetramer interface [polypeptide binding]; other site 474186007024 homodimer interface [polypeptide binding]; other site 474186007025 active site 474186007026 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 474186007027 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 474186007028 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 474186007029 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 474186007030 FMN binding site [chemical binding]; other site 474186007031 substrate binding site [chemical binding]; other site 474186007032 putative catalytic residue [active] 474186007033 acyl carrier protein; Provisional; Region: acpP; PRK00982 474186007034 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 474186007035 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 474186007036 dimer interface [polypeptide binding]; other site 474186007037 active site 474186007038 CoA binding pocket [chemical binding]; other site 474186007039 Transcriptional regulators [Transcription]; Region: MarR; COG1846 474186007040 MarR family; Region: MarR_2; pfam12802 474186007041 Protein of unknown function (DUF1797); Region: DUF1797; pfam08796 474186007042 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 474186007043 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 474186007044 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 474186007045 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 474186007046 putative ADP-binding pocket [chemical binding]; other site 474186007047 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 474186007048 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 474186007049 general stress protein 13; Validated; Region: PRK08059 474186007050 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 474186007051 RNA binding site [nucleotide binding]; other site 474186007052 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 474186007053 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 474186007054 pyridoxal 5'-phosphate binding site [chemical binding]; other site 474186007055 homodimer interface [polypeptide binding]; other site 474186007056 catalytic residue [active] 474186007057 Protein of unknown function (DUF3955); Region: DUF3955; pfam13127 474186007058 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 474186007059 active site 474186007060 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 474186007061 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 474186007062 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 474186007063 Phosphoglycerate Dehydrogenase, 2-hydroxyacid dehydrogenase family; Region: PGDH_1; cd12155 474186007064 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 474186007065 putative ligand binding site [chemical binding]; other site 474186007066 NAD binding site [chemical binding]; other site 474186007067 catalytic site [active] 474186007068 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 474186007069 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 474186007070 active site 474186007071 metal binding site [ion binding]; metal-binding site 474186007072 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 474186007073 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 474186007074 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 474186007075 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 474186007076 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 474186007077 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 474186007078 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 474186007079 dimer interface [polypeptide binding]; other site 474186007080 conserved gate region; other site 474186007081 putative PBP binding loops; other site 474186007082 ABC-ATPase subunit interface; other site 474186007083 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 474186007084 dimer interface [polypeptide binding]; other site 474186007085 conserved gate region; other site 474186007086 putative PBP binding loops; other site 474186007087 ABC-ATPase subunit interface; other site 474186007088 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 474186007089 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 474186007090 Walker A/P-loop; other site 474186007091 ATP binding site [chemical binding]; other site 474186007092 Q-loop/lid; other site 474186007093 ABC transporter signature motif; other site 474186007094 Walker B; other site 474186007095 D-loop; other site 474186007096 H-loop/switch region; other site 474186007097 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 474186007098 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 474186007099 Ligand binding site; other site 474186007100 Putative Catalytic site; other site 474186007101 DXD motif; other site 474186007102 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 474186007103 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 474186007104 TrkA-N domain; Region: TrkA_N; pfam02254 474186007105 TrkA-C domain; Region: TrkA_C; pfam02080 474186007106 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 474186007107 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 474186007108 active site 474186007109 phosphorylation site [posttranslational modification] 474186007110 intermolecular recognition site; other site 474186007111 dimerization interface [polypeptide binding]; other site 474186007112 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 474186007113 DNA binding residues [nucleotide binding] 474186007114 dimerization interface [polypeptide binding]; other site 474186007115 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 474186007116 Histidine kinase; Region: HisKA_3; pfam07730 474186007117 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 474186007118 ATP binding site [chemical binding]; other site 474186007119 Mg2+ binding site [ion binding]; other site 474186007120 G-X-G motif; other site 474186007121 Predicted membrane protein [Function unknown]; Region: COG4758 474186007122 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 474186007123 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 474186007124 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 474186007125 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 474186007126 YceG-like family; Region: YceG; pfam02618 474186007127 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 474186007128 dimerization interface [polypeptide binding]; other site 474186007129 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 474186007130 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 474186007131 motif II; other site 474186007132 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 474186007133 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 474186007134 active site 474186007135 homodimer interface [polypeptide binding]; other site 474186007136 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 474186007137 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 474186007138 trimer interface [polypeptide binding]; other site 474186007139 putative metal binding site [ion binding]; other site 474186007140 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 474186007141 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 474186007142 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 474186007143 Walker A/P-loop; other site 474186007144 ATP binding site [chemical binding]; other site 474186007145 Q-loop/lid; other site 474186007146 ABC transporter signature motif; other site 474186007147 Walker B; other site 474186007148 D-loop; other site 474186007149 H-loop/switch region; other site 474186007150 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 474186007151 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 474186007152 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 474186007153 Walker A/P-loop; other site 474186007154 ATP binding site [chemical binding]; other site 474186007155 Q-loop/lid; other site 474186007156 ABC transporter signature motif; other site 474186007157 Walker B; other site 474186007158 D-loop; other site 474186007159 H-loop/switch region; other site 474186007160 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832 474186007161 Protein of unknown function (DUF1447); Region: DUF1447; pfam07288 474186007162 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 474186007163 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 474186007164 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 474186007165 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 474186007166 DNA-binding site [nucleotide binding]; DNA binding site 474186007167 RNA-binding motif; other site 474186007168 hypothetical protein; Reviewed; Region: PRK00024 474186007169 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 474186007170 MPN+ (JAMM) motif; other site 474186007171 Zinc-binding site [ion binding]; other site 474186007172 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 474186007173 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 474186007174 motif II; other site 474186007175 folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499 474186007176 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 474186007177 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 474186007178 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 474186007179 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 474186007180 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 474186007181 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 474186007182 active site 474186007183 HIGH motif; other site 474186007184 nucleotide binding site [chemical binding]; other site 474186007185 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 474186007186 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 474186007187 active site 474186007188 KMSKS motif; other site 474186007189 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 474186007190 tRNA binding surface [nucleotide binding]; other site 474186007191 anticodon binding site; other site 474186007192 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 474186007193 T-box leader; OG1RF_nc10038 474186007194 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 474186007195 dimer interface [polypeptide binding]; other site 474186007196 catalytic triad [active] 474186007197 peroxidatic and resolving cysteines [active] 474186007198 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 474186007199 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 474186007200 CoA binding domain; Region: CoA_binding; pfam02629 474186007201 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 474186007202 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 474186007203 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 474186007204 Ligand Binding Site [chemical binding]; other site 474186007205 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 474186007206 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 474186007207 Clostridial hydrophobic W; Region: ChW; pfam07538 474186007208 Clostridial hydrophobic W; Region: ChW; pfam07538 474186007209 Clostridial hydrophobic W; Region: ChW; pfam07538 474186007210 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 474186007211 non-specific DNA binding site [nucleotide binding]; other site 474186007212 salt bridge; other site 474186007213 sequence-specific DNA binding site [nucleotide binding]; other site 474186007214 Bacterial regulatory protein, arsR family; Region: HTH_5; pfam01022 474186007215 putative DNA binding site [nucleotide binding]; other site 474186007216 putative Zn2+ binding site [ion binding]; other site 474186007217 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 474186007218 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 474186007219 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 474186007220 NAD(P) binding site [chemical binding]; other site 474186007221 active site 474186007222 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 474186007223 active site 474186007224 substrate binding site [chemical binding]; other site 474186007225 trimer interface [polypeptide binding]; other site 474186007226 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 474186007227 CoA binding site [chemical binding]; other site 474186007228 Transcriptional regulator [Transcription]; Region: LysR; COG0583 474186007229 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 474186007230 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 474186007231 dimerization interface [polypeptide binding]; other site 474186007232 Sugar transport protein; Region: Sugar_transport; pfam06800 474186007233 D-ribose pyranase; Provisional; Region: PRK11797 474186007234 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 474186007235 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 474186007236 substrate binding site [chemical binding]; other site 474186007237 dimer interface [polypeptide binding]; other site 474186007238 ATP binding site [chemical binding]; other site 474186007239 Transcriptional regulators [Transcription]; Region: PurR; COG1609 474186007240 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 474186007241 DNA binding site [nucleotide binding] 474186007242 domain linker motif; other site 474186007243 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 474186007244 dimerization interface [polypeptide binding]; other site 474186007245 ligand binding site [chemical binding]; other site 474186007246 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 474186007247 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 474186007248 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 474186007249 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 474186007250 active site 474186007251 P-loop; other site 474186007252 phosphorylation site [posttranslational modification] 474186007253 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 474186007254 PRD domain; Region: PRD; pfam00874 474186007255 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 474186007256 active site 474186007257 P-loop; other site 474186007258 phosphorylation site [posttranslational modification] 474186007259 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 474186007260 active site 474186007261 phosphorylation site [posttranslational modification] 474186007262 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 474186007263 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 474186007264 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 474186007265 WxL domain surface cell wall-binding; Region: WxL; pfam13731 474186007266 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 474186007267 Amidinotransferase; Region: Amidinotransf; cl12043 474186007268 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 474186007269 dimer interface [polypeptide binding]; other site 474186007270 Alkaline phosphatase homologues; Region: alkPPc; smart00098 474186007271 active site 474186007272 MutS domain III; Region: MutS_III; pfam05192 474186007273 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 474186007274 Walker A/P-loop; other site 474186007275 ATP binding site [chemical binding]; other site 474186007276 Q-loop/lid; other site 474186007277 ABC transporter signature motif; other site 474186007278 Walker B; other site 474186007279 D-loop; other site 474186007280 H-loop/switch region; other site 474186007281 conserved hypothetical protein EF_0839/AHA_3917; Region: EF_0839; TIGR03581 474186007282 uncharacterized pyridoxal phosphate-dependent enzyme; Region: selA_rel; TIGR01437 474186007283 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 474186007284 catalytic residue [active] 474186007285 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 474186007286 PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609 474186007287 PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830 474186007288 active site 474186007289 phosphorylation site [posttranslational modification] 474186007290 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 474186007291 active pocket/dimerization site; other site 474186007292 active site 474186007293 phosphorylation site [posttranslational modification] 474186007294 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 474186007295 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 474186007296 Walker A motif; other site 474186007297 ATP binding site [chemical binding]; other site 474186007298 Walker B motif; other site 474186007299 arginine finger; other site 474186007300 PRD domain; Region: PRD; pfam00874 474186007301 Transcriptional antiterminator [Transcription]; Region: COG3933 474186007302 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 474186007303 active site 474186007304 active pocket/dimerization site; other site 474186007305 phosphorylation site [posttranslational modification] 474186007306 PRD domain; Region: PRD; pfam00874 474186007307 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 474186007308 catalytic core [active] 474186007309 amidase; Provisional; Region: PRK06529 474186007310 Amidase; Region: Amidase; cl11426 474186007311 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 474186007312 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 474186007313 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 474186007314 FtsX-like permease family; Region: FtsX; pfam02687 474186007315 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 474186007316 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 474186007317 Walker A/P-loop; other site 474186007318 ATP binding site [chemical binding]; other site 474186007319 Q-loop/lid; other site 474186007320 ABC transporter signature motif; other site 474186007321 Walker B; other site 474186007322 D-loop; other site 474186007323 H-loop/switch region; other site 474186007324 HlyD family secretion protein; Region: HlyD_2; pfam12700 474186007325 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 474186007326 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 474186007327 active site residue [active] 474186007328 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 474186007329 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 474186007330 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 474186007331 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 474186007332 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 474186007333 active site residue [active] 474186007334 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 474186007335 active site residue [active] 474186007336 Uncharacterized protein YrkD from Bacillus subtilis and related domains; this domain superfamily was previously known as part of DUF156; Region: BsYrkD-like_DUF156; cd10155 474186007337 putative homodimer interface [polypeptide binding]; other site 474186007338 putative homotetramer interface [polypeptide binding]; other site 474186007339 putative metal binding site [ion binding]; other site 474186007340 putative homodimer-homodimer interface [polypeptide binding]; other site 474186007341 putative allosteric switch controlling residues; other site 474186007342 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 474186007343 D-galactonate transporter; Region: 2A0114; TIGR00893 474186007344 putative substrate translocation pore; other site 474186007345 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 474186007346 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 474186007347 catalytic residue [active] 474186007348 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 474186007349 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 474186007350 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 474186007351 putative allantoin catabolism protein; Region: ura-cupin; TIGR03214 474186007352 Protein of unknown function (DUF861); Region: Cupin_3; cl17594 474186007353 Cupin domain; Region: Cupin_2; cl17218 474186007354 allantoate amidohydrolase; Region: AllC; TIGR03176 474186007355 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 474186007356 active site 474186007357 metal binding site [ion binding]; metal-binding site 474186007358 dimer interface [polypeptide binding]; other site 474186007359 allantoinase; Provisional; Region: PRK08044 474186007360 L-Hydantoinases (L-HYDs) and Allantoinase (ALN); L-Hydantoinases are a member of the dihydropyrimidinase family, which catalyzes the reversible hydrolytic ring opening of dihydropyrimidines and hydantoins (five-membered cyclic diamides used in...; Region: L-HYD_ALN; cd01315 474186007361 active site 474186007362 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily, YbbW-like; solute-binding domain; Region: SLC-NCS1sbd_YbbW-like; cd11485 474186007363 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 474186007364 Na binding site [ion binding]; other site 474186007365 putative substrate binding site [chemical binding]; other site 474186007366 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 474186007367 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 474186007368 Coenzyme A binding pocket [chemical binding]; other site 474186007369 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 474186007370 MarR family; Region: MarR; pfam01047 474186007371 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 474186007372 Sulfate transporter family; Region: Sulfate_transp; pfam00916 474186007373 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 474186007374 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 474186007375 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 474186007376 active site 474186007377 Glucose-6-phosphate 1-dehydrogenase (EC 1.1.1.49); Region: G6PD_bact; pfam10786 474186007378 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 474186007379 Cl- selectivity filter; other site 474186007380 Cl- binding residues [ion binding]; other site 474186007381 pore gating glutamate residue; other site 474186007382 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 474186007383 DRTGG domain; Region: DRTGG; pfam07085 474186007384 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 474186007385 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 474186007386 Protein of unknown function (DUF2877); Region: DUF2877; pfam11392 474186007387 CoA binding domain; Region: CoA_binding; pfam02629 474186007388 CoA-ligase; Region: Ligase_CoA; pfam00549 474186007389 Protein of unknown function (DUF1116); Region: DUF1116; pfam06545 474186007390 Mga helix-turn-helix domain; Region: Mga; pfam05043 474186007391 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 474186007392 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 474186007393 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 474186007394 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 474186007395 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 474186007396 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 474186007397 Soluble P-type ATPase [General function prediction only]; Region: COG4087 474186007398 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 474186007399 serine/threonine transporter SstT; Provisional; Region: PRK13628 474186007400 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 474186007401 Ion channel; Region: Ion_trans_2; pfam07885 474186007402 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 474186007403 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 474186007404 dimerization interface 3.5A [polypeptide binding]; other site 474186007405 active site 474186007406 Sigma factor regulator N-terminal; Region: Sigma_reg_N; pfam13800 474186007407 Sigma factor regulator C-terminal; Region: Sigma_reg_C; pfam13791 474186007408 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 474186007409 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 474186007410 DNA binding residues [nucleotide binding] 474186007411 DinB superfamily; Region: DinB_2; pfam12867 474186007412 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 474186007413 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 474186007414 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 474186007415 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 474186007416 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 474186007417 Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues; Region: GAG_Lyase; cd01083 474186007418 substrate binding site [chemical binding]; other site 474186007419 catalytic residues [active] 474186007420 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 474186007421 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 474186007422 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 474186007423 protein binding site [polypeptide binding]; other site 474186007424 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 474186007425 putative tRNA-binding site [nucleotide binding]; other site 474186007426 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 474186007427 Ligand Binding Site [chemical binding]; other site 474186007428 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 474186007429 catalytic residues [active] 474186007430 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 474186007431 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 474186007432 oligomer interface [polypeptide binding]; other site 474186007433 active site 474186007434 metal binding site [ion binding]; metal-binding site 474186007435 Predicted small secreted protein [Function unknown]; Region: COG5584 474186007436 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 474186007437 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 474186007438 peptide binding site [polypeptide binding]; other site 474186007439 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 474186007440 PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609 474186007441 potential frameshift: common BLAST hit: gi|29377502|ref|NP_816656.1| N-acetylglucosamine-6-phosphate deacetylase 474186007442 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 474186007443 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 474186007444 active site 474186007445 dimer interface [polypeptide binding]; other site 474186007446 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 474186007447 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 474186007448 active site 474186007449 phosphorylation site [posttranslational modification] 474186007450 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 474186007451 active pocket/dimerization site; other site 474186007452 active site 474186007453 phosphorylation site [posttranslational modification] 474186007454 Acyltransferase family; Region: Acyl_transf_3; pfam01757 474186007455 Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803 474186007456 putative active site [active] 474186007457 YdjC motif; other site 474186007458 Mg binding site [ion binding]; other site 474186007459 putative homodimer interface [polypeptide binding]; other site 474186007460 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 474186007461 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 474186007462 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 474186007463 putative active site [active] 474186007464 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 474186007465 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 474186007466 putative active site [active] 474186007467 putative proton-coupled thiamine transporter YuaJ; Region: thia_yuaJ; TIGR02357 474186007468 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 474186007469 Predicted membrane protein [Function unknown]; Region: COG3212 474186007470 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 474186007471 Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165 474186007472 active site 474186007473 catalytic site [active] 474186007474 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 474186007475 Low molecular weight phosphatase family; Region: LMWPc; cd00115 474186007476 active site 474186007477 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 474186007478 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 474186007479 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 474186007480 rod shape-determining protein MreD; Region: shape_MreD; TIGR03426 474186007481 rod shape-determining protein MreC; Provisional; Region: PRK13922 474186007482 rod shape-determining protein MreC; Region: MreC; pfam04085 474186007483 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 474186007484 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 474186007485 RNase E interface [polypeptide binding]; other site 474186007486 trimer interface [polypeptide binding]; other site 474186007487 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 474186007488 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 474186007489 RNase E interface [polypeptide binding]; other site 474186007490 trimer interface [polypeptide binding]; other site 474186007491 active site 474186007492 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 474186007493 putative nucleic acid binding region [nucleotide binding]; other site 474186007494 G-X-X-G motif; other site 474186007495 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 474186007496 RNA binding site [nucleotide binding]; other site 474186007497 domain interface; other site 474186007498 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 474186007499 16S/18S rRNA binding site [nucleotide binding]; other site 474186007500 S13e-L30e interaction site [polypeptide binding]; other site 474186007501 25S rRNA binding site [nucleotide binding]; other site 474186007502 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 474186007503 active site 474186007504 catalytic residues [active] 474186007505 metal binding site [ion binding]; metal-binding site 474186007506 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 474186007507 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 474186007508 active site 474186007509 motif I; other site 474186007510 motif II; other site 474186007511 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 474186007512 active site 474186007513 motif I; other site 474186007514 motif II; other site 474186007515 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 474186007516 A new structural DNA glycosylase containing HEAT-like repeats; Region: AlkD_like_1; cd07064 474186007517 active site 474186007518 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927 474186007519 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 474186007520 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 474186007521 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 474186007522 RNA binding surface [nucleotide binding]; other site 474186007523 BioY family; Region: BioY; pfam02632 474186007524 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 474186007525 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462 474186007526 Catalytic site [active] 474186007527 WxL domain surface cell wall-binding; Region: WxL; pfam13731 474186007528 WxL domain surface cell wall-binding; Region: WxL; pfam13731 474186007529 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4493 474186007530 Protein of unknown function (DUF1054); Region: DUF1054; pfam06335 474186007531 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 474186007532 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 474186007533 peptidase T; Region: peptidase-T; TIGR01882 474186007534 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 474186007535 metal binding site [ion binding]; metal-binding site 474186007536 dimer interface [polypeptide binding]; other site 474186007537 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 474186007538 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 474186007539 peptide binding site [polypeptide binding]; other site 474186007540 T-box leader; OG1RF_nc10040 474186007541 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 474186007542 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 474186007543 putative ligand binding residues [chemical binding]; other site 474186007544 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 474186007545 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 474186007546 Walker A/P-loop; other site 474186007547 ATP binding site [chemical binding]; other site 474186007548 Q-loop/lid; other site 474186007549 ABC transporter signature motif; other site 474186007550 Walker B; other site 474186007551 D-loop; other site 474186007552 H-loop/switch region; other site 474186007553 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 474186007554 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 474186007555 ABC-ATPase subunit interface; other site 474186007556 dimer interface [polypeptide binding]; other site 474186007557 putative PBP binding regions; other site 474186007558 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 474186007559 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 474186007560 ABC-ATPase subunit interface; other site 474186007561 dimer interface [polypeptide binding]; other site 474186007562 putative PBP binding regions; other site 474186007563 Protein of unknown function (DUF1694); Region: DUF1694; pfam07997 474186007564 glutamate--cysteine ligase/gamma-glutamylcysteine synthetase, Streptococcus agalactiae type; Region: glu_cys_lig_rel; TIGR01435 474186007565 Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352 474186007566 ATP-grasp domain; Region: ATP-grasp_4; cl17255 474186007567 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 474186007568 Isochorismatase family; Region: Isochorismatase; pfam00857 474186007569 catalytic triad [active] 474186007570 conserved cis-peptide bond; other site 474186007571 Uncharacterized conserved protein [Function unknown]; Region: COG1284 474186007572 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 474186007573 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 474186007574 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 474186007575 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 474186007576 Cupin superfamily (DUF985); Region: Cupin_5; pfam06172 474186007577 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 474186007578 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 474186007579 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 474186007580 P loop; other site 474186007581 GTP binding site [chemical binding]; other site 474186007582 sugar phosphate phosphatase; Provisional; Region: PRK10513 474186007583 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 474186007584 active site 474186007585 motif I; other site 474186007586 motif II; other site 474186007587 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 474186007588 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 474186007589 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 474186007590 Walker A/P-loop; other site 474186007591 ATP binding site [chemical binding]; other site 474186007592 Q-loop/lid; other site 474186007593 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 474186007594 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 474186007595 ABC transporter signature motif; other site 474186007596 Walker B; other site 474186007597 D-loop; other site 474186007598 H-loop/switch region; other site 474186007599 ribonuclease III; Reviewed; Region: rnc; PRK00102 474186007600 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 474186007601 dimerization interface [polypeptide binding]; other site 474186007602 active site 474186007603 metal binding site [ion binding]; metal-binding site 474186007604 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 474186007605 dsRNA binding site [nucleotide binding]; other site 474186007606 The substrate binding component of an ABC-type lactococcal OppA-like transport system contains; Region: PBP2_Lactococcal_OppA_like; cd08510 474186007607 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 474186007608 peptide binding site [polypeptide binding]; other site 474186007609 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SapC; COG4171 474186007610 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 474186007611 dimer interface [polypeptide binding]; other site 474186007612 conserved gate region; other site 474186007613 putative PBP binding loops; other site 474186007614 ABC-ATPase subunit interface; other site 474186007615 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 474186007616 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 474186007617 dimer interface [polypeptide binding]; other site 474186007618 conserved gate region; other site 474186007619 putative PBP binding loops; other site 474186007620 ABC-ATPase subunit interface; other site 474186007621 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 474186007622 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 474186007623 Walker A/P-loop; other site 474186007624 ATP binding site [chemical binding]; other site 474186007625 Q-loop/lid; other site 474186007626 ABC transporter signature motif; other site 474186007627 Walker B; other site 474186007628 D-loop; other site 474186007629 H-loop/switch region; other site 474186007630 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 474186007631 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 474186007632 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 474186007633 Walker A/P-loop; other site 474186007634 ATP binding site [chemical binding]; other site 474186007635 Q-loop/lid; other site 474186007636 ABC transporter signature motif; other site 474186007637 Walker B; other site 474186007638 D-loop; other site 474186007639 H-loop/switch region; other site 474186007640 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 474186007641 acyl carrier protein; Provisional; Region: acpP; PRK00982 474186007642 putative phosphate acyltransferase; Provisional; Region: PRK05331 474186007643 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 474186007644 Y-family of DNA polymerases; Region: PolY; cl12025 474186007645 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 474186007646 generic binding surface II; other site 474186007647 ssDNA binding site; other site 474186007648 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 474186007649 ATP binding site [chemical binding]; other site 474186007650 putative Mg++ binding site [ion binding]; other site 474186007651 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 474186007652 nucleotide binding region [chemical binding]; other site 474186007653 ATP-binding site [chemical binding]; other site 474186007654 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 474186007655 DAK2 domain; Region: Dak2; pfam02734 474186007656 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 474186007657 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 474186007658 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 474186007659 active site 474186007660 phosphorylation site [posttranslational modification] 474186007661 intermolecular recognition site; other site 474186007662 dimerization interface [polypeptide binding]; other site 474186007663 LytTr DNA-binding domain; Region: LytTR; pfam04397 474186007664 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 474186007665 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 474186007666 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 474186007667 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 474186007668 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 474186007669 Walker A/P-loop; other site 474186007670 ATP binding site [chemical binding]; other site 474186007671 Q-loop/lid; other site 474186007672 ABC transporter signature motif; other site 474186007673 Walker B; other site 474186007674 D-loop; other site 474186007675 H-loop/switch region; other site 474186007676 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 474186007677 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 474186007678 Thiamine pyrophosphokinase; Region: TPK; cd07995 474186007679 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 474186007680 active site 474186007681 dimerization interface [polypeptide binding]; other site 474186007682 thiamine binding site [chemical binding]; other site 474186007683 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 474186007684 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 474186007685 substrate binding site [chemical binding]; other site 474186007686 hexamer interface [polypeptide binding]; other site 474186007687 metal binding site [ion binding]; metal-binding site 474186007688 GTPase RsgA; Reviewed; Region: PRK00098 474186007689 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 474186007690 RNA binding site [nucleotide binding]; other site 474186007691 homodimer interface [polypeptide binding]; other site 474186007692 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 474186007693 GTPase/Zn-binding domain interface [polypeptide binding]; other site 474186007694 GTP/Mg2+ binding site [chemical binding]; other site 474186007695 G4 box; other site 474186007696 G5 box; other site 474186007697 G1 box; other site 474186007698 Switch I region; other site 474186007699 G2 box; other site 474186007700 G3 box; other site 474186007701 Switch II region; other site 474186007702 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 474186007703 Catalytic domain of Protein Kinases; Region: PKc; cd00180 474186007704 active site 474186007705 ATP binding site [chemical binding]; other site 474186007706 substrate binding site [chemical binding]; other site 474186007707 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 474186007708 substrate binding site [chemical binding]; other site 474186007709 activation loop (A-loop); other site 474186007710 activation loop (A-loop); other site 474186007711 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 474186007712 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 474186007713 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 474186007714 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 474186007715 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 474186007716 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 474186007717 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 474186007718 active site 474186007719 16S rRNA methyltransferase B; Provisional; Region: PRK14902 474186007720 NusB family; Region: NusB; pfam01029 474186007721 putative RNA binding site [nucleotide binding]; other site 474186007722 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 474186007723 S-adenosylmethionine binding site [chemical binding]; other site 474186007724 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 474186007725 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 474186007726 putative active site [active] 474186007727 substrate binding site [chemical binding]; other site 474186007728 putative cosubstrate binding site; other site 474186007729 catalytic site [active] 474186007730 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 474186007731 substrate binding site [chemical binding]; other site 474186007732 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 474186007733 active site 474186007734 catalytic residues [active] 474186007735 metal binding site [ion binding]; metal-binding site 474186007736 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 474186007737 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 474186007738 ATP binding site [chemical binding]; other site 474186007739 putative Mg++ binding site [ion binding]; other site 474186007740 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 474186007741 nucleotide binding region [chemical binding]; other site 474186007742 ATP-binding site [chemical binding]; other site 474186007743 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 474186007744 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 474186007745 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 474186007746 catalytic site [active] 474186007747 G-X2-G-X-G-K; other site 474186007748 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 474186007749 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 474186007750 Domain of unknown function (DUF1958); Region: DUF1958; pfam09211 474186007751 acyl-CoA esterase; Provisional; Region: PRK10673 474186007752 hypothetical protein; Provisional; Region: PRK11820 474186007753 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 474186007754 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 474186007755 Uncharacterized protein conserved in bacteria (DUF2128); Region: DUF2128; pfam09901 474186007756 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 474186007757 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 474186007758 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 474186007759 active site 474186007760 intersubunit interface [polypeptide binding]; other site 474186007761 catalytic residue [active] 474186007762 mannonate dehydratase; Provisional; Region: PRK03906 474186007763 mannonate dehydratase; Region: uxuA; TIGR00695 474186007764 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 474186007765 active pocket/dimerization site; other site 474186007766 active site 474186007767 phosphorylation site [posttranslational modification] 474186007768 PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830 474186007769 active site 474186007770 phosphorylation site [posttranslational modification] 474186007771 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 474186007772 PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609 474186007773 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 474186007774 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 474186007775 putative active site [active] 474186007776 metal binding site [ion binding]; metal-binding site 474186007777 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 474186007778 Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_12; cd12177 474186007779 putative ligand binding site [chemical binding]; other site 474186007780 putative NAD binding site [chemical binding]; other site 474186007781 catalytic site [active] 474186007782 Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023 474186007783 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 474186007784 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 474186007785 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 474186007786 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 474186007787 putative active site [active] 474186007788 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Region: pgsA; TIGR00560 474186007789 LXG domain of WXG superfamily; Region: LXG; pfam04740 474186007790 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 474186007791 Helix-turn-helix domain; Region: HTH_25; pfam13413 474186007792 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 474186007793 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 474186007794 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 474186007795 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 474186007796 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 474186007797 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 474186007798 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 474186007799 WxL domain surface cell wall-binding; Region: WxL; pfam13731 474186007800 WxL domain surface cell wall-binding; Region: WxL; pfam13731 474186007801 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 474186007802 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 474186007803 DNA-binding site [nucleotide binding]; DNA binding site 474186007804 UTRA domain; Region: UTRA; pfam07702 474186007805 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 474186007806 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 474186007807 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 474186007808 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 474186007809 beta-phosphoglucomutase; Region: bPGM; TIGR01990 474186007810 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 474186007811 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 474186007812 motif II; other site 474186007813 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 474186007814 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 474186007815 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 474186007816 active site 474186007817 methionine sulfoxide reductase B; Provisional; Region: PRK00222 474186007818 SelR domain; Region: SelR; pfam01641 474186007819 Maf-like protein; Region: Maf; pfam02545 474186007820 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 474186007821 active site 474186007822 dimer interface [polypeptide binding]; other site 474186007823 DNA mismatch repair enzyme (predicted ATPase) [DNA replication, recombination, and repair]; Region: MutL; COG0323 474186007824 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 474186007825 ATP binding site [chemical binding]; other site 474186007826 Mg2+ binding site [ion binding]; other site 474186007827 G-X-G motif; other site 474186007828 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 474186007829 ATP binding site [chemical binding]; other site 474186007830 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 474186007831 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 474186007832 MutS domain I; Region: MutS_I; pfam01624 474186007833 MutS domain II; Region: MutS_II; pfam05188 474186007834 MutS domain III; Region: MutS_III; pfam05192 474186007835 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 474186007836 Walker A/P-loop; other site 474186007837 ATP binding site [chemical binding]; other site 474186007838 Q-loop/lid; other site 474186007839 ABC transporter signature motif; other site 474186007840 Walker B; other site 474186007841 D-loop; other site 474186007842 H-loop/switch region; other site 474186007843 Protein of unknown function (DUF964); Region: DUF964; cl01483 474186007844 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 474186007845 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 474186007846 putative active site [active] 474186007847 metal binding site [ion binding]; metal-binding site 474186007848 homodimer binding site [polypeptide binding]; other site 474186007849 phosphodiesterase; Provisional; Region: PRK12704 474186007850 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 474186007851 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 474186007852 Zn2+ binding site [ion binding]; other site 474186007853 Mg2+ binding site [ion binding]; other site 474186007854 recombinase A; Provisional; Region: recA; PRK09354 474186007855 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 474186007856 hexamer interface [polypeptide binding]; other site 474186007857 Walker A motif; other site 474186007858 ATP binding site [chemical binding]; other site 474186007859 Walker B motif; other site 474186007860 competence damage-inducible protein A; Provisional; Region: PRK00549 474186007861 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 474186007862 putative MPT binding site; other site 474186007863 Competence-damaged protein; Region: CinA; pfam02464 474186007864 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 474186007865 NADH(P)-binding; Region: NAD_binding_10; pfam13460 474186007866 NAD binding site [chemical binding]; other site 474186007867 substrate binding site [chemical binding]; other site 474186007868 putative active site [active] 474186007869 Predicted transcriptional regulator [Transcription]; Region: COG1959 474186007870 Transcriptional regulator; Region: Rrf2; pfam02082 474186007871 hypothetical protein; Provisional; Region: PRK11770 474186007872 Domain of unknown function (DUF307); Region: DUF307; pfam03733 474186007873 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588 474186007874 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 474186007875 metal binding site [ion binding]; metal-binding site 474186007876 dimer interface [polypeptide binding]; other site 474186007877 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 474186007878 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 474186007879 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 474186007880 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 474186007881 DNA binding residues [nucleotide binding] 474186007882 Mga helix-turn-helix domain; Region: Mga; pfam05043 474186007883 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 474186007884 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 474186007885 WxL domain surface cell wall-binding; Region: WxL; pfam13731 474186007886 WxL domain surface cell wall-binding; Region: WxL; pfam13731 474186007887 WxL domain surface cell wall-binding; Region: WxL; pfam13731 474186007888 WxL domain surface cell wall-binding; Region: WxL; pfam13731 474186007889 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 474186007890 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 474186007891 Isochorismatase family; Region: Isochorismatase; pfam00857 474186007892 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 474186007893 catalytic triad [active] 474186007894 conserved cis-peptide bond; other site 474186007895 antiholin-like protein LrgB; Provisional; Region: PRK04288 474186007896 murein hydrolase regulator LrgA; Provisional; Region: PRK04125 474186007897 two-component response regulator; Provisional; Region: PRK14084 474186007898 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 474186007899 active site 474186007900 phosphorylation site [posttranslational modification] 474186007901 intermolecular recognition site; other site 474186007902 dimerization interface [polypeptide binding]; other site 474186007903 LytTr DNA-binding domain; Region: LytTR; pfam04397 474186007904 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 474186007905 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 474186007906 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 474186007907 Histidine kinase; Region: His_kinase; pfam06580 474186007908 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 474186007909 ATP binding site [chemical binding]; other site 474186007910 Mg2+ binding site [ion binding]; other site 474186007911 G-X-G motif; other site 474186007912 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 474186007913 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 474186007914 ABC-type metal ion transport system, permease component [Inorganic ion transport and metabolism]; Region: AbcD; COG2011 474186007915 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 474186007916 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 474186007917 Walker A/P-loop; other site 474186007918 ATP binding site [chemical binding]; other site 474186007919 Q-loop/lid; other site 474186007920 ABC transporter signature motif; other site 474186007921 Walker B; other site 474186007922 D-loop; other site 474186007923 H-loop/switch region; other site 474186007924 OsmC-like protein; Region: OsmC; pfam02566 474186007925 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 474186007926 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 474186007927 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 474186007928 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 474186007929 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 474186007930 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 474186007931 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 474186007932 metal binding site [ion binding]; metal-binding site 474186007933 YodA lipocalin-like domain; Region: YodA; pfam09223 474186007934 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 474186007935 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 474186007936 FMN binding site [chemical binding]; other site 474186007937 active site 474186007938 catalytic residues [active] 474186007939 substrate binding site [chemical binding]; other site 474186007940 inner membrane transport permease; Provisional; Region: PRK15066 474186007941 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 474186007942 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 474186007943 ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263 474186007944 Walker A/P-loop; other site 474186007945 ATP binding site [chemical binding]; other site 474186007946 Q-loop/lid; other site 474186007947 ABC transporter signature motif; other site 474186007948 Walker B; other site 474186007949 D-loop; other site 474186007950 H-loop/switch region; other site 474186007951 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 474186007952 active pocket/dimerization site; other site 474186007953 active site 474186007954 phosphorylation site [posttranslational modification] 474186007955 PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830 474186007956 active site 474186007957 phosphorylation site [posttranslational modification] 474186007958 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 474186007959 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 474186007960 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 474186007961 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 474186007962 Walker A motif; other site 474186007963 ATP binding site [chemical binding]; other site 474186007964 Walker B motif; other site 474186007965 arginine finger; other site 474186007966 Transcriptional antiterminator [Transcription]; Region: COG3933 474186007967 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 474186007968 active pocket/dimerization site; other site 474186007969 active site 474186007970 phosphorylation site [posttranslational modification] 474186007971 PRD domain; Region: PRD; pfam00874 474186007972 Surface antigen [General function prediction only]; Region: COG3942 474186007973 CHAP domain; Region: CHAP; cl17642 474186007974 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 474186007975 Sulfatase; Region: Sulfatase; cl17466 474186007976 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 474186007977 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 474186007978 23S rRNA interface [nucleotide binding]; other site 474186007979 L3 interface [polypeptide binding]; other site 474186007980 Ribosomal protein L13 leader; OG1RF_nc10041 474186007981 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 474186007982 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 474186007983 dimerization interface [polypeptide binding]; other site 474186007984 DPS ferroxidase diiron center [ion binding]; other site 474186007985 ion pore; other site 474186007986 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 474186007987 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 474186007988 N- and C-terminal domain interface [polypeptide binding]; other site 474186007989 active site 474186007990 catalytic site [active] 474186007991 metal binding site [ion binding]; metal-binding site 474186007992 carbohydrate binding site [chemical binding]; other site 474186007993 ATP binding site [chemical binding]; other site 474186007994 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 474186007995 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 474186007996 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 474186007997 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 474186007998 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 474186007999 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 474186008000 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 474186008001 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 474186008002 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 474186008003 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 474186008004 DNA binding site [nucleotide binding] 474186008005 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 474186008006 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 474186008007 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 474186008008 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 474186008009 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 474186008010 RPB1 interaction site [polypeptide binding]; other site 474186008011 RPB10 interaction site [polypeptide binding]; other site 474186008012 RPB11 interaction site [polypeptide binding]; other site 474186008013 RPB3 interaction site [polypeptide binding]; other site 474186008014 RPB12 interaction site [polypeptide binding]; other site 474186008015 PemK-like protein; Region: PemK; pfam02452 474186008016 Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082); Region: DUF2082; pfam09855 474186008017 Biotin operon repressor [Transcription]; Region: BirA; COG1654 474186008018 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 474186008019 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 474186008020 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 474186008021 Chitin binding domain; Region: Chitin_bind_3; pfam03067 474186008022 ykoK leader; OG1RF_nc10042 474186008023 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 474186008024 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 474186008025 active site 474186008026 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 474186008027 WxL domain surface cell wall-binding; Region: WxL; pfam13731 474186008028 WxL domain surface cell wall-binding; Region: WxL; pfam13731 474186008029 WxL domain surface cell wall-binding; Region: WxL; pfam13731 474186008030 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Provisional; Region: PRK13387 474186008031 UbiA prenyltransferase family; Region: UbiA; pfam01040 474186008032 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 474186008033 ApbE family; Region: ApbE; pfam02424 474186008034 This conserved region includes the FMN-binding site of the NqrC protein as well as the NosR and NirI regulatory proteins; Region: FMN_bind; smart00900 474186008035 FMN-binding domain; Region: FMN_bind; pfam04205 474186008036 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 474186008037 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 474186008038 Listerrria innocua Lin0431 is similar to the N-Utilization Substance G (NusG) N terminal (NGN) insert (DII); Region: Lin0431_like; cd09911 474186008039 trimer interface [polypeptide binding]; other site 474186008040 Heptaprenyl diphosphate synthase component I; Region: Hpre_diP_synt_I; pfam07456 474186008041 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 474186008042 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 474186008043 substrate binding pocket [chemical binding]; other site 474186008044 chain length determination region; other site 474186008045 substrate-Mg2+ binding site; other site 474186008046 catalytic residues [active] 474186008047 aspartate-rich region 1; other site 474186008048 active site lid residues [active] 474186008049 aspartate-rich region 2; other site 474186008050 dihydropteroate synthase; Region: DHPS; TIGR01496 474186008051 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 474186008052 substrate binding pocket [chemical binding]; other site 474186008053 dimer interface [polypeptide binding]; other site 474186008054 inhibitor binding site; inhibition site 474186008055 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 474186008056 active site 474186008057 dimerization interface [polypeptide binding]; other site 474186008058 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 474186008059 GTP cyclohydrolase I; Provisional; Region: PLN03044 474186008060 active site 474186008061 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 474186008062 catalytic center binding site [active] 474186008063 ATP binding site [chemical binding]; other site 474186008064 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 474186008065 homooctamer interface [polypeptide binding]; other site 474186008066 active site 474186008067 glutathione-disulfide reductase, animal/bacterial; Region: gluta_reduc_1; TIGR01421 474186008068 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 474186008069 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 474186008070 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 474186008071 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 474186008072 non-specific DNA binding site [nucleotide binding]; other site 474186008073 salt bridge; other site 474186008074 sequence-specific DNA binding site [nucleotide binding]; other site 474186008075 Predicted Zn peptidase [Amino acid transport and metabolism]; Region: COG2856 474186008076 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 474186008077 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 474186008078 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 474186008079 Uncharacterized conserved protein [Function unknown]; Region: COG3535 474186008080 Purine-cytosine permease and related proteins [Nucleotide transport and metabolism]; Region: CodB; COG1457 474186008081 Na binding site [ion binding]; other site 474186008082 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 474186008083 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 474186008084 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 474186008085 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 474186008086 Peptidase family U32; Region: Peptidase_U32; pfam01136 474186008087 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 474186008088 Peptidase family U32; Region: Peptidase_U32; pfam01136 474186008089 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 474186008090 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 474186008091 Clp amino terminal domain; Region: Clp_N; pfam02861 474186008092 Clp amino terminal domain; Region: Clp_N; pfam02861 474186008093 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 474186008094 Walker A motif; other site 474186008095 ATP binding site [chemical binding]; other site 474186008096 Walker B motif; other site 474186008097 arginine finger; other site 474186008098 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 474186008099 Walker A motif; other site 474186008100 ATP binding site [chemical binding]; other site 474186008101 Walker B motif; other site 474186008102 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 474186008103 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848 474186008104 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 474186008105 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 474186008106 homodimer interface [polypeptide binding]; other site 474186008107 substrate-cofactor binding pocket; other site 474186008108 pyridoxal 5'-phosphate binding site [chemical binding]; other site 474186008109 catalytic residue [active] 474186008110 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 474186008111 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 474186008112 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 474186008113 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 474186008114 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 474186008115 putative active site [active] 474186008116 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 474186008117 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 474186008118 active site 474186008119 phosphorylation site [posttranslational modification] 474186008120 intermolecular recognition site; other site 474186008121 dimerization interface [polypeptide binding]; other site 474186008122 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 474186008123 DNA binding site [nucleotide binding] 474186008124 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 474186008125 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 474186008126 dimer interface [polypeptide binding]; other site 474186008127 phosphorylation site [posttranslational modification] 474186008128 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 474186008129 ATP binding site [chemical binding]; other site 474186008130 Mg2+ binding site [ion binding]; other site 474186008131 G-X-G motif; other site 474186008132 seryl-tRNA synthetase; Provisional; Region: PRK05431 474186008133 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 474186008134 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 474186008135 dimer interface [polypeptide binding]; other site 474186008136 active site 474186008137 motif 1; other site 474186008138 motif 2; other site 474186008139 motif 3; other site 474186008140 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 474186008141 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 474186008142 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 474186008143 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 474186008144 active site 474186008145 6-pyruvoyl-tetrahydropterin synthase related domain; membrane protein; Region: PTPS_related; pfam10131 474186008146 Protein of unknown function (DUF1129); Region: DUF1129; pfam06570 474186008147 GTP-binding protein YchF; Reviewed; Region: PRK09601 474186008148 YchF GTPase; Region: YchF; cd01900 474186008149 G1 box; other site 474186008150 GTP/Mg2+ binding site [chemical binding]; other site 474186008151 Switch I region; other site 474186008152 G2 box; other site 474186008153 Switch II region; other site 474186008154 G3 box; other site 474186008155 G4 box; other site 474186008156 G5 box; other site 474186008157 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 474186008158 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 474186008159 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 474186008160 ParB-like nuclease domain; Region: ParBc; pfam02195 474186008161 KorB domain; Region: KorB; pfam08535 474186008162 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 474186008163 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 474186008164 P-loop; other site 474186008165 Magnesium ion binding site [ion binding]; other site 474186008166 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 474186008167 Magnesium ion binding site [ion binding]; other site 474186008168 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 474186008169 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 474186008170 Protein of unknown function (DUF3114); Region: DUF3114; pfam11311 474186008171 myosin-cross-reactive antigen; Provisional; Region: PRK13977 474186008172 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 474186008173 active site 474186008174 intersubunit interactions; other site 474186008175 catalytic residue [active] 474186008176 PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; pfam03829 474186008177 PTS system, glucitol/sorbitol-specific, IIBC component; Region: EIIBC-GUT; TIGR00825 474186008178 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 474186008179 Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663 474186008180 PTS system enzyme II sorbitol-specific factor; Region: EII-GUT; pfam03608 474186008181 Glucitol operon activator protein (GutM); Region: GutM; pfam06923 474186008182 HTH domain; Region: HTH_11; pfam08279 474186008183 HTH domain; Region: HTH_11; pfam08279 474186008184 PRD domain; Region: PRD; pfam00874 474186008185 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 474186008186 active site 474186008187 P-loop; other site 474186008188 phosphorylation site [posttranslational modification] 474186008189 Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2; Region: PTS_EIIA_2; pfam00359 474186008190 active site 474186008191 phosphorylation site [posttranslational modification] 474186008192 sorbitol-6-phosphate 2-dehydrogenase; Provisional; Region: PRK06171 474186008193 classical (c) SDRs; Region: SDR_c; cd05233 474186008194 NAD(P) binding site [chemical binding]; other site 474186008195 active site 474186008196 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 474186008197 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 474186008198 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 474186008199 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 474186008200 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 474186008201 trmE is a tRNA modification GTPase; Region: trmE; cd04164 474186008202 G1 box; other site 474186008203 GTP/Mg2+ binding site [chemical binding]; other site 474186008204 Switch I region; other site 474186008205 G2 box; other site 474186008206 Switch II region; other site 474186008207 G3 box; other site 474186008208 G4 box; other site 474186008209 G5 box; other site 474186008210 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 474186008211 ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; cl00768 474186008212 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 474186008213 Malic enzyme, N-terminal domain; Region: malic; pfam00390 474186008214 Malic enzyme, NAD binding domain; Region: Malic_M; smart00919 474186008215 NAD(P) binding pocket [chemical binding]; other site 474186008216 oxaloacetate decarboxylase; Provisional; Region: PRK12331 474186008217 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 474186008218 active site 474186008219 catalytic residues [active] 474186008220 metal binding site [ion binding]; metal-binding site 474186008221 homodimer binding site [polypeptide binding]; other site 474186008222 2'-(5''-triphosphoribosyl)-3'- dephospho-CoA:apo-citrate lyase; Reviewed; Region: citX; PRK01392 474186008223 Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051 474186008224 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 474186008225 citrate lyase subunit gamma; Provisional; Region: PRK13253 474186008226 Citrate lyase synthetase [Energy production and conversion]; Region: CitC; COG3053 474186008227 Citrate lyase ligase; Region: Citrate_lyase_ligase; cd02169 474186008228 putative active site [active] 474186008229 (T/H)XGH motif; other site 474186008230 Na+-transporting oxaloacetate decarboxylase beta subunit; Region: OAD_beta; pfam03977 474186008231 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06549 474186008232 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 474186008233 carboxyltransferase (CT) interaction site; other site 474186008234 biotinylation site [posttranslational modification]; other site 474186008235 H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851 474186008236 Citrate transporter; Region: CitMHS; pfam03600 474186008237 Transcriptional regulators [Transcription]; Region: FadR; COG2186 474186008238 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 474186008239 DNA-binding site [nucleotide binding]; DNA binding site 474186008240 FCD domain; Region: FCD; pfam07729 474186008241 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 474186008242 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 474186008243 active site 474186008244 phosphorylation site [posttranslational modification] 474186008245 intermolecular recognition site; other site 474186008246 dimerization interface [polypeptide binding]; other site 474186008247 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 474186008248 DNA binding site [nucleotide binding] 474186008249 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 474186008250 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 474186008251 G-X-X-G motif; other site 474186008252 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 474186008253 RxxxH motif; other site 474186008254 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 474186008255 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 474186008256 ribonuclease P; Reviewed; Region: rnpA; PRK00499 474186008257 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399