-- dump date   	20140619_074029
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
1261557000001	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
1261557000002	DnaA N-terminal domain; Region: DnaA_N; pfam11638
1261557000003	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1261557000004	Walker A motif; other site
1261557000005	ATP binding site [chemical binding]; other site
1261557000006	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
1261557000007	Walker B motif; other site
1261557000008	arginine finger; other site
1261557000009	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
1261557000010	DnaA box-binding interface [nucleotide binding]; other site
1261557000011	DNA polymerase III subunit beta; Validated; Region: PRK05643
1261557000012	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
1261557000013	putative DNA binding surface [nucleotide binding]; other site
1261557000014	dimer interface [polypeptide binding]; other site
1261557000015	beta-clamp/clamp loader binding surface; other site
1261557000016	beta-clamp/translesion DNA polymerase binding surface; other site
1261557000017	S4 domain protein YaaA; Region: YaaA_near_RecF; TIGR02988
1261557000018	recombination protein F; Reviewed; Region: recF; PRK00064
1261557000019	ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242
1261557000020	Walker A/P-loop; other site
1261557000021	ATP binding site [chemical binding]; other site
1261557000022	Q-loop/lid; other site
1261557000023	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1261557000024	ABC transporter signature motif; other site
1261557000025	Walker B; other site
1261557000026	D-loop; other site
1261557000027	H-loop/switch region; other site
1261557000028	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
1261557000029	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1261557000030	Mg2+ binding site [ion binding]; other site
1261557000031	G-X-G motif; other site
1261557000032	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
1261557000033	anchoring element; other site
1261557000034	dimer interface [polypeptide binding]; other site
1261557000035	ATP binding site [chemical binding]; other site
1261557000036	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
1261557000037	active site
1261557000038	putative metal-binding site [ion binding]; other site
1261557000039	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
1261557000040	DNA gyrase subunit A; Validated; Region: PRK05560
1261557000041	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
1261557000042	CAP-like domain; other site
1261557000043	active site
1261557000044	primary dimer interface [polypeptide binding]; other site
1261557000045	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1261557000046	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1261557000047	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1261557000048	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1261557000049	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1261557000050	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
1261557000051	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
1261557000052	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
1261557000053	dimer interface [polypeptide binding]; other site
1261557000054	ssDNA binding site [nucleotide binding]; other site
1261557000055	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1261557000056	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
1261557000057	Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887
1261557000058	Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967
1261557000059	DHH family; Region: DHH; pfam01368
1261557000060	DHHA1 domain; Region: DHHA1; pfam02272
1261557000061	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
1261557000062	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
1261557000063	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
1261557000064	replicative DNA helicase; Provisional; Region: PRK05748
1261557000065	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
1261557000066	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
1261557000067	Walker A motif; other site
1261557000068	ATP binding site [chemical binding]; other site
1261557000069	Walker B motif; other site
1261557000070	DNA binding loops [nucleotide binding]
1261557000071	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
1261557000072	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
1261557000073	GDP-binding site [chemical binding]; other site
1261557000074	ACT binding site; other site
1261557000075	IMP binding site; other site
1261557000076	EDD domain protein, DegV family; Region: DegV; TIGR00762
1261557000077	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
1261557000078	ABC transporter ATP-binding protein; Provisional; Region: PRK15064
1261557000079	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1261557000080	Walker A/P-loop; other site
1261557000081	ATP binding site [chemical binding]; other site
1261557000082	Q-loop/lid; other site
1261557000083	ABC transporter signature motif; other site
1261557000084	Walker B; other site
1261557000085	D-loop; other site
1261557000086	H-loop/switch region; other site
1261557000087	ABC transporter; Region: ABC_tran_2; pfam12848
1261557000088	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1261557000089	Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775
1261557000090	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221
1261557000091	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1261557000092	Walker A motif; other site
1261557000093	ATP binding site [chemical binding]; other site
1261557000094	Walker B motif; other site
1261557000095	arginine finger; other site
1261557000096	Transcriptional antiterminator [Transcription]; Region: COG3933
1261557000097	PRD domain; Region: PRD; pfam00874
1261557000098	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025
1261557000099	active pocket/dimerization site; other site
1261557000100	active site
1261557000101	phosphorylation site [posttranslational modification]
1261557000102	PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cd00133
1261557000103	active site
1261557000104	P-loop; other site
1261557000105	phosphorylation site [posttranslational modification]
1261557000106	PRD domain; Region: PRD; pfam00874
1261557000107	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
1261557000108	active site
1261557000109	phosphorylation site [posttranslational modification]
1261557000110	PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088
1261557000111	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
1261557000112	active pocket/dimerization site; other site
1261557000113	active site
1261557000114	phosphorylation site [posttranslational modification]
1261557000115	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
1261557000116	active site
1261557000117	phosphorylation site [posttranslational modification]
1261557000118	PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065
1261557000119	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716
1261557000120	Domain of unknown function (DUF956); Region: DUF956; pfam06115
1261557000121	Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247
1261557000122	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
1261557000123	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
1261557000124	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
1261557000125	putative active site [active]
1261557000126	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
1261557000127	PTS system, maltose and glucose-specific IIBC component; Region: PTS-IIBC-malX; TIGR02004
1261557000128	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1261557000129	active site turn [active]
1261557000130	phosphorylation site [posttranslational modification]
1261557000131	Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168
1261557000132	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1261557000133	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1261557000134	homodimer interface [polypeptide binding]; other site
1261557000135	catalytic residue [active]
1261557000136	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
1261557000137	homotrimer interaction site [polypeptide binding]; other site
1261557000138	putative active site [active]
1261557000139	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
1261557000140	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
1261557000141	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
1261557000142	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
1261557000143	dimer interface [polypeptide binding]; other site
1261557000144	active site
1261557000145	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
1261557000146	dimer interface [polypeptide binding]; other site
1261557000147	active site
1261557000148	Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486
1261557000149	Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296
1261557000150	NAD binding site [chemical binding]; other site
1261557000151	sugar binding site [chemical binding]; other site
1261557000152	divalent metal binding site [ion binding]; other site
1261557000153	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1261557000154	dimer interface [polypeptide binding]; other site
1261557000155	Predicted integral membrane protein [Function unknown]; Region: COG0392
1261557000156	Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706
1261557000157	Uncharacterized conserved protein [Function unknown]; Region: COG2898
1261557000158	Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924
1261557000159	Bacterial membrane protein YfhO; Region: YfhO; pfam09586
1261557000160	Protein of unknown function (DUF1706); Region: DUF1706; pfam08020
1261557000161	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
1261557000162	dimer interface [polypeptide binding]; other site
1261557000163	Predicted transcriptional regulator [Transcription]; Region: COG2378
1261557000164	HTH domain; Region: HTH_11; pfam08279
1261557000165	WYL domain; Region: WYL; pfam13280
1261557000166	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
1261557000167	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
1261557000168	putative catalytic cysteine [active]
1261557000169	Glutamate 5-kinase [Amino acid transport and metabolism]; Region: ProB; COG0263
1261557000170	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
1261557000171	nucleotide binding site [chemical binding]; other site
1261557000172	homotetrameric interface [polypeptide binding]; other site
1261557000173	putative phosphate binding site [ion binding]; other site
1261557000174	putative allosteric binding site; other site
1261557000175	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
1261557000176	trimer interface [polypeptide binding]; other site
1261557000177	active site
1261557000178	DNA repair protein RadA; Provisional; Region: PRK11823
1261557000179	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
1261557000180	Walker A motif/ATP binding site; other site
1261557000181	ATP binding site [chemical binding]; other site
1261557000182	Walker B motif; other site
1261557000183	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
1261557000184	Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956
1261557000185	PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877
1261557000186	putative active site [active]
1261557000187	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
1261557000188	homotrimer interaction site [polypeptide binding]; other site
1261557000189	zinc binding site [ion binding]; other site
1261557000190	CDP-binding sites; other site
1261557000191	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
1261557000192	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
1261557000193	HIGH motif; other site
1261557000194	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
1261557000195	active site
1261557000196	KMSKS motif; other site
1261557000197	serine O-acetyltransferase; Region: cysE; TIGR01172
1261557000198	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
1261557000199	trimer interface [polypeptide binding]; other site
1261557000200	active site
1261557000201	substrate binding site [chemical binding]; other site
1261557000202	CoA binding site [chemical binding]; other site
1261557000203	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
1261557000204	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
1261557000205	active site
1261557000206	HIGH motif; other site
1261557000207	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
1261557000208	KMSKS motif; other site
1261557000209	Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963
1261557000210	tRNA binding surface [nucleotide binding]; other site
1261557000211	anticodon binding site; other site
1261557000212	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
1261557000213	active site
1261557000214	metal binding site [ion binding]; metal-binding site
1261557000215	dimerization interface [polypeptide binding]; other site
1261557000216	rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186
1261557000217	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
1261557000218	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
1261557000219	YacP-like NYN domain; Region: NYN_YacP; pfam05991
1261557000220	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
1261557000221	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1261557000222	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257
1261557000223	DNA binding residues [nucleotide binding]
1261557000224	Protein of unknown function (DUF1021); Region: DUF1021; pfam06257
1261557000225	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128
1261557000226	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
1261557000227	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
1261557000228	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
1261557000229	Metal binding protein AcdA.  These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017
1261557000230	metal binding site [ion binding]; metal-binding site
1261557000231	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1261557000232	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
1261557000233	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
1261557000234	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1261557000235	ABC-ATPase subunit  interface; other site
1261557000236	dimer interface [polypeptide binding]; other site
1261557000237	putative PBP binding regions; other site
1261557000238	pur operon repressor; Provisional; Region: PRK09213
1261557000239	Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182
1261557000240	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1261557000241	active site
1261557000242	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354
1261557000243	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
1261557000244	Substrate binding site; other site
1261557000245	Mg++ binding site; other site
1261557000246	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
1261557000247	active site
1261557000248	substrate binding site [chemical binding]; other site
1261557000249	CoA binding site [chemical binding]; other site
1261557000250	bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase precursor protein; Reviewed; Region: PRK09419
1261557000251	Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410
1261557000252	active site
1261557000253	metal binding site [ion binding]; metal-binding site
1261557000254	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
1261557000255	Staphylococcus aureus SA0022 and related proteins, N-terminal metallophosphatase domain; Region: MPP_SA0022_N; cd07408
1261557000256	putative active site [active]
1261557000257	putative metal binding site [ion binding]; other site
1261557000258	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
1261557000259	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
1261557000260	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
1261557000261	peptide binding site [polypeptide binding]; other site
1261557000262	Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979
1261557000263	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347
1261557000264	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
1261557000265	probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620
1261557000266	Abi-like protein; Region: Abi_2; pfam07751
1261557000267	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
1261557000268	RuvA N terminal domain; Region: RuvA_N; pfam01330
1261557000269	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
1261557000270	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1261557000271	Walker A motif; other site
1261557000272	ATP binding site [chemical binding]; other site
1261557000273	Walker B motif; other site
1261557000274	arginine finger; other site
1261557000275	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
1261557000276	N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130
1261557000277	N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729
1261557000278	putative active site cavity [active]
1261557000279	alpha-glucosidase; Provisional; Region: PRK10137
1261557000280	Protein of unknown function, DUF608; Region: DUF608; pfam04685
1261557000281	Trehalase; Region: Trehalase; cl17346
1261557000282	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
1261557000283	non-specific DNA binding site [nucleotide binding]; other site
1261557000284	salt bridge; other site
1261557000285	sequence-specific DNA binding site [nucleotide binding]; other site
1261557000286	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1261557000287	Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027
1261557000288	ligand binding site [chemical binding]; other site
1261557000289	flexible hinge region; other site
1261557000290	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
1261557000291	oxidoreductase; Provisional; Region: PRK07985
1261557000292	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1261557000293	NAD(P) binding site [chemical binding]; other site
1261557000294	active site
1261557000295	Small integral membrane protein (DUF2273); Region: DUF2273; cl11575
1261557000296	Asp23 family; Region: Asp23; pfam03780
1261557000297	Asp23 family; Region: Asp23; pfam03780
1261557000298	Predicted membrane protein [Function unknown]; Region: COG2261
1261557000299	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1261557000300	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1261557000301	putative substrate translocation pore; other site
1261557000302	Mga helix-turn-helix domain; Region: Mga; pfam05043
1261557000303	Mga helix-turn-helix domain; Region: Mga; pfam05043
1261557000304	Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932
1261557000305	Collagen binding domain; Region: Collagen_bind; pfam05737
1261557000306	Collagen binding domain; Region: Collagen_bind; pfam05737
1261557000307	Collagen binding domain; Region: Collagen_bind; pfam05737
1261557000308	Collagen binding domain; Region: Collagen_bind; pfam05737
1261557000309	Collagen binding domain; Region: Collagen_bind; pfam05737
1261557000310	Cna protein B-type domain; Region: Cna_B; pfam05738
1261557000311	Cna protein B-type domain; Region: Cna_B; pfam05738
1261557000312	Cna protein B-type domain; Region: Cna_B; pfam05738
1261557000313	Cna protein B-type domain; Region: Cna_B; pfam05738
1261557000314	Cna protein B-type domain; Region: Cna_B; pfam05738
1261557000315	Cna protein B-type domain; Region: Cna_B; pfam05738
1261557000316	Cna protein B-type domain; Region: Cna_B; pfam05738
1261557000317	Cna protein B-type domain; Region: Cna_B; pfam05738
1261557000318	Cna protein B-type domain; Region: Cna_B; pfam05738
1261557000319	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
1261557000320	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
1261557000321	Mga helix-turn-helix domain; Region: Mga; pfam05043
1261557000322	twin-arg-translocated uncharacterized repeat protein; Region: RR_plus_rpt_1; TIGR03808
1261557000323	Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116
1261557000324	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
1261557000325	Helix-turn-helix domain; Region: HTH_38; pfam13936
1261557000326	Integrase core domain; Region: rve; pfam00665
1261557000327	YheO-like PAS domain; Region: PAS_6; pfam08348
1261557000328	HTH domain; Region: HTH_22; pfam13309
1261557000329	Transposase, Mutator family; Region: Transposase_mut; pfam00872
1261557000330	MULE transposase domain; Region: MULE; pfam10551
1261557000331	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425
1261557000332	Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303
1261557000333	L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719
1261557000334	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
1261557000335	Serine dehydratase alpha chain; Region: SDH_alpha; cl12120
1261557000336	L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760
1261557000337	seryl-tRNA synthetase; Provisional; Region: PRK05431
1261557000338	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
1261557000339	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
1261557000340	dimer interface [polypeptide binding]; other site
1261557000341	active site
1261557000342	motif 1; other site
1261557000343	motif 2; other site
1261557000344	motif 3; other site
1261557000345	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1261557000346	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
1261557000347	Arginine repressor [Transcription]; Region: ArgR; COG1438
1261557000348	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
1261557000349	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
1261557000350	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
1261557000351	Arginine repressor [Transcription]; Region: ArgR; COG1438
1261557000352	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
1261557000353	arginine deiminase; Provisional; Region: PRK01388
1261557000354	ornithine carbamoyltransferase; Validated; Region: PRK02102
1261557000355	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
1261557000356	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
1261557000357	carbamate kinase; Reviewed; Region: PRK12686
1261557000358	AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235
1261557000359	putative substrate binding site [chemical binding]; other site
1261557000360	nucleotide binding site [chemical binding]; other site
1261557000361	nucleotide binding site [chemical binding]; other site
1261557000362	homodimer interface [polypeptide binding]; other site
1261557000363	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1261557000364	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1261557000365	ligand binding site [chemical binding]; other site
1261557000366	flexible hinge region; other site
1261557000367	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
1261557000368	putative switch regulator; other site
1261557000369	non-specific DNA interactions [nucleotide binding]; other site
1261557000370	DNA binding site [nucleotide binding]
1261557000371	sequence specific DNA binding site [nucleotide binding]; other site
1261557000372	putative cAMP binding site [chemical binding]; other site
1261557000373	Predicted membrane protein [Function unknown]; Region: COG1288
1261557000374	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
1261557000375	Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141
1261557000376	potential catalytic triad [active]
1261557000377	conserved cys residue [active]
1261557000378	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1261557000379	dimerization interface [polypeptide binding]; other site
1261557000380	putative DNA binding site [nucleotide binding]; other site
1261557000381	putative Zn2+ binding site [ion binding]; other site
1261557000382	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
1261557000383	alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289
1261557000384	putative NAD(P) binding site [chemical binding]; other site
1261557000385	Endo-beta-N-acetylglucosaminidases are bacterial chitinases that hydrolyze the chitin core of various asparagine (N)-linked glycans and glycoproteins. The endo-beta-N-acetylglucosaminidases have a glycosyl hydrolase family 18 (GH18) catalytic domain; Region: GH18_EndoS-like; cd06542
1261557000386	active site
1261557000387	Glycosyl hydrolase family 20 (GH20) catalytic domain of dispersin B (DspB), lacto-N-biosidase (LnbB) and related proteins. Dispersin B is a soluble beta-N-acetylglucosamidase found in bacteria that hydrolyzes the beta-1,6-linkages of PGA (poly-beta-(1,6)...; Region: GH20_DspB_LnbB-like; cd06564
1261557000388	Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728
1261557000389	active site
1261557000390	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
1261557000391	homotrimer interaction site [polypeptide binding]; other site
1261557000392	putative active site [active]
1261557000393	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
1261557000394	homotrimer interaction site [polypeptide binding]; other site
1261557000395	putative active site [active]
1261557000396	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
1261557000397	homotrimer interaction site [polypeptide binding]; other site
1261557000398	putative active site [active]
1261557000399	MepB protein; Region: MepB; pfam08877
1261557000400	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
1261557000401	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1261557000402	DNA-binding site [nucleotide binding]; DNA binding site
1261557000403	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1261557000404	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1261557000405	homodimer interface [polypeptide binding]; other site
1261557000406	catalytic residue [active]
1261557000407	Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423
1261557000408	ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400
1261557000409	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
1261557000410	Cobalamin adenosyltransferase; Region: Cob_adeno_trans; cl00920
1261557000411	GMP synthase; Reviewed; Region: guaA; PRK00074
1261557000412	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
1261557000413	AMP/PPi binding site [chemical binding]; other site
1261557000414	candidate oxyanion hole; other site
1261557000415	catalytic triad [active]
1261557000416	potential glutamine specificity residues [chemical binding]; other site
1261557000417	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
1261557000418	ATP Binding subdomain [chemical binding]; other site
1261557000419	Dimerization subdomain; other site
1261557000420	pantothenate kinase; Provisional; Region: PRK05439
1261557000421	Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025
1261557000422	ATP-binding site [chemical binding]; other site
1261557000423	CoA-binding site [chemical binding]; other site
1261557000424	Mg2+-binding site [ion binding]; other site
1261557000425	Isoamyl-acetate hydrolyzing esterase-like proteins. SGNH_hydrolase subfamily similar to the Saccharomyces cerevisiae IAH1. IAH1 may be the major esterase that hydrolyses isoamyl acetate in sake mash.  The SGNH-family of hydrolases is a diverse family of...; Region: Isoamyl_acetate_hydrolase_like; cd01838
1261557000426	catalytic triad [active]
1261557000427	oxyanion hole [active]
1261557000428	active site
1261557000429	Methyltransferase domain; Region: Methyltransf_31; pfam13847
1261557000430	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1261557000431	S-adenosylmethionine binding site [chemical binding]; other site
1261557000432	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816
1261557000433	Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320
1261557000434	active site
1261557000435	purine riboside binding site [chemical binding]; other site
1261557000436	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1261557000437	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1261557000438	DNA binding site [nucleotide binding]
1261557000439	domain linker motif; other site
1261557000440	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
1261557000441	dimerization interface [polypeptide binding]; other site
1261557000442	ligand binding site [chemical binding]; other site
1261557000443	pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078
1261557000444	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
1261557000445	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
1261557000446	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831
1261557000447	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
1261557000448	intersubunit interface [polypeptide binding]; other site
1261557000449	active site
1261557000450	catalytic residue [active]
1261557000451	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
1261557000452	active site
1261557000453	catalytic motif [active]
1261557000454	Zn binding site [ion binding]; other site
1261557000455	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
1261557000456	Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354
1261557000457	ligand binding site [chemical binding]; other site
1261557000458	Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354
1261557000459	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
1261557000460	ligand binding site [chemical binding]; other site
1261557000461	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
1261557000462	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1261557000463	Walker A/P-loop; other site
1261557000464	ATP binding site [chemical binding]; other site
1261557000465	Q-loop/lid; other site
1261557000466	ABC transporter signature motif; other site
1261557000467	Walker B; other site
1261557000468	D-loop; other site
1261557000469	H-loop/switch region; other site
1261557000470	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
1261557000471	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1261557000472	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
1261557000473	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
1261557000474	TM-ABC transporter signature motif; other site
1261557000475	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1261557000476	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
1261557000477	TM-ABC transporter signature motif; other site
1261557000478	Protein of unknown function (DUF1211); Region: DUF1211; cl01421
1261557000479	phosphopentomutase; Provisional; Region: PRK05362
1261557000480	Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676
1261557000481	purine nucleoside phosphorylase; Provisional; Region: PRK08202
1261557000482	purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819
1261557000483	Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820
1261557000484	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
1261557000485	Periplasmic binding protein FeuA.  These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138
1261557000486	putative ligand binding residues [chemical binding]; other site
1261557000487	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
1261557000488	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
1261557000489	Walker A/P-loop; other site
1261557000490	ATP binding site [chemical binding]; other site
1261557000491	Q-loop/lid; other site
1261557000492	ABC transporter signature motif; other site
1261557000493	Walker B; other site
1261557000494	D-loop; other site
1261557000495	H-loop/switch region; other site
1261557000496	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
1261557000497	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1261557000498	ABC-ATPase subunit  interface; other site
1261557000499	dimer interface [polypeptide binding]; other site
1261557000500	putative PBP binding regions; other site
1261557000501	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1261557000502	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1261557000503	ABC-ATPase subunit  interface; other site
1261557000504	dimer interface [polypeptide binding]; other site
1261557000505	putative PBP binding regions; other site
1261557000506	Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979
1261557000507	Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187
1261557000508	dimer interface [polypeptide binding]; other site
1261557000509	active site
1261557000510	metal binding site [ion binding]; metal-binding site
1261557000511	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1261557000512	catalytic core [active]
1261557000513	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1261557000514	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
1261557000515	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
1261557000516	catalytic residues [active]
1261557000517	catalytic nucleophile [active]
1261557000518	Presynaptic Site I dimer interface [polypeptide binding]; other site
1261557000519	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
1261557000520	Synaptic Flat tetramer interface [polypeptide binding]; other site
1261557000521	Synaptic Site I dimer interface [polypeptide binding]; other site
1261557000522	DNA binding site [nucleotide binding]
1261557000523	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
1261557000524	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1261557000525	active site
1261557000526	dimer interface [polypeptide binding]; other site
1261557000527	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
1261557000528	S17 interaction site [polypeptide binding]; other site
1261557000529	S8 interaction site; other site
1261557000530	16S rRNA interaction site [nucleotide binding]; other site
1261557000531	streptomycin interaction site [chemical binding]; other site
1261557000532	23S rRNA interaction site [nucleotide binding]; other site
1261557000533	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
1261557000534	30S ribosomal protein S7; Validated; Region: PRK05302
1261557000535	elongation factor G; Reviewed; Region: PRK00007
1261557000536	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
1261557000537	G1 box; other site
1261557000538	putative GEF interaction site [polypeptide binding]; other site
1261557000539	GTP/Mg2+ binding site [chemical binding]; other site
1261557000540	Switch I region; other site
1261557000541	G2 box; other site
1261557000542	G3 box; other site
1261557000543	Switch II region; other site
1261557000544	G4 box; other site
1261557000545	G5 box; other site
1261557000546	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
1261557000547	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
1261557000548	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
1261557000549	elongation factor Tu; Reviewed; Region: PRK00049
1261557000550	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
1261557000551	G1 box; other site
1261557000552	GEF interaction site [polypeptide binding]; other site
1261557000553	GTP/Mg2+ binding site [chemical binding]; other site
1261557000554	Switch I region; other site
1261557000555	G2 box; other site
1261557000556	G3 box; other site
1261557000557	Switch II region; other site
1261557000558	G4 box; other site
1261557000559	G5 box; other site
1261557000560	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
1261557000561	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
1261557000562	Antibiotic Binding Site [chemical binding]; other site
1261557000563	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
1261557000564	dimer interface [polypeptide binding]; other site
1261557000565	substrate binding site [chemical binding]; other site
1261557000566	ATP binding site [chemical binding]; other site
1261557000567	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
1261557000568	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1261557000569	S-adenosylmethionine binding site [chemical binding]; other site
1261557000570	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
1261557000571	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
1261557000572	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
1261557000573	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
1261557000574	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
1261557000575	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
1261557000576	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
1261557000577	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
1261557000578	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
1261557000579	putative translocon binding site; other site
1261557000580	protein-rRNA interface [nucleotide binding]; other site
1261557000581	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
1261557000582	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
1261557000583	G-X-X-G motif; other site
1261557000584	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
1261557000585	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
1261557000586	23S rRNA interface [nucleotide binding]; other site
1261557000587	5S rRNA interface [nucleotide binding]; other site
1261557000588	putative antibiotic binding site [chemical binding]; other site
1261557000589	L25 interface [polypeptide binding]; other site
1261557000590	L27 interface [polypeptide binding]; other site
1261557000591	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
1261557000592	23S rRNA interface [nucleotide binding]; other site
1261557000593	putative translocon interaction site; other site
1261557000594	signal recognition particle (SRP54) interaction site; other site
1261557000595	L23 interface [polypeptide binding]; other site
1261557000596	trigger factor interaction site; other site
1261557000597	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
1261557000598	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
1261557000599	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
1261557000600	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
1261557000601	RNA binding site [nucleotide binding]; other site
1261557000602	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
1261557000603	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
1261557000604	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
1261557000605	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061
1261557000606	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
1261557000607	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
1261557000608	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
1261557000609	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
1261557000610	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
1261557000611	5S rRNA interface [nucleotide binding]; other site
1261557000612	L27 interface [polypeptide binding]; other site
1261557000613	23S rRNA interface [nucleotide binding]; other site
1261557000614	L5 interface [polypeptide binding]; other site
1261557000615	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
1261557000616	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
1261557000617	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
1261557000618	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
1261557000619	23S rRNA binding site [nucleotide binding]; other site
1261557000620	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
1261557000621	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
1261557000622	SecY translocase; Region: SecY; pfam00344
1261557000623	adenylate kinase; Reviewed; Region: adk; PRK00279
1261557000624	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
1261557000625	AMP-binding site [chemical binding]; other site
1261557000626	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
1261557000627	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
1261557000628	rRNA binding site [nucleotide binding]; other site
1261557000629	predicted 30S ribosome binding site; other site
1261557000630	Ribosomal protein L36; Region: Ribosomal_L36; pfam00444
1261557000631	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
1261557000632	30S ribosomal protein S13; Region: bact_S13; TIGR03631
1261557000633	30S ribosomal protein S11; Validated; Region: PRK05309
1261557000634	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
1261557000635	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
1261557000636	alphaNTD homodimer interface [polypeptide binding]; other site
1261557000637	alphaNTD - beta interaction site [polypeptide binding]; other site
1261557000638	alphaNTD - beta' interaction site [polypeptide binding]; other site
1261557000639	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
1261557000640	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
1261557000641	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
1261557000642	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_subfamily5; cd08019
1261557000643	metal binding site [ion binding]; metal-binding site
1261557000644	putative dimer interface [polypeptide binding]; other site
1261557000645	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635
1261557000646	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
1261557000647	Walker A/P-loop; other site
1261557000648	ATP binding site [chemical binding]; other site
1261557000649	Q-loop/lid; other site
1261557000650	ABC transporter signature motif; other site
1261557000651	Walker B; other site
1261557000652	D-loop; other site
1261557000653	H-loop/switch region; other site
1261557000654	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13634
1261557000655	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
1261557000656	Walker A/P-loop; other site
1261557000657	ATP binding site [chemical binding]; other site
1261557000658	Q-loop/lid; other site
1261557000659	ABC transporter signature motif; other site
1261557000660	Walker B; other site
1261557000661	D-loop; other site
1261557000662	H-loop/switch region; other site
1261557000663	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
1261557000664	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
1261557000665	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
1261557000666	dimerization interface 3.5A [polypeptide binding]; other site
1261557000667	active site
1261557000668	hypothetical protein; Provisional; Region: PRK00967
1261557000669	Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525
1261557000670	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
1261557000671	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1261557000672	Coenzyme A binding pocket [chemical binding]; other site
1261557000673	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1261557000674	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
1261557000675	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1261557000676	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1261557000677	Walker A/P-loop; other site
1261557000678	ATP binding site [chemical binding]; other site
1261557000679	Q-loop/lid; other site
1261557000680	ABC transporter signature motif; other site
1261557000681	Walker B; other site
1261557000682	D-loop; other site
1261557000683	H-loop/switch region; other site
1261557000684	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1261557000685	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1261557000686	substrate binding pocket [chemical binding]; other site
1261557000687	membrane-bound complex binding site; other site
1261557000688	hinge residues; other site
1261557000689	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1261557000690	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1261557000691	dimer interface [polypeptide binding]; other site
1261557000692	conserved gate region; other site
1261557000693	putative PBP binding loops; other site
1261557000694	ABC-ATPase subunit interface; other site
1261557000695	NAD-dependent deacetylase; Provisional; Region: PRK00481
1261557000696	SIR2H: Uncharacterized prokaryotic Sir2 homologs from several gram positive bacterial species and Fusobacteria; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone...; Region: SIR2H; cd01411
1261557000697	NAD+ binding site [chemical binding]; other site
1261557000698	substrate binding site [chemical binding]; other site
1261557000699	putative Zn binding site [ion binding]; other site
1261557000700	maltose O-acetyltransferase; Provisional; Region: PRK10092
1261557000701	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
1261557000702	active site
1261557000703	substrate binding site [chemical binding]; other site
1261557000704	trimer interface [polypeptide binding]; other site
1261557000705	CoA binding site [chemical binding]; other site
1261557000706	monofunctional chorismate mutase, gram positive-type, clade 2; Region: CM_mono_grmpos; TIGR01805
1261557000707	Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827
1261557000708	HTH domain; Region: HTH_11; pfam08279
1261557000709	3H domain; Region: 3H; pfam02829
1261557000710	E4 protein; Provisional; Region: PHA03420
1261557000711	Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705
1261557000712	CHAP domain; Region: CHAP; pfam05257
1261557000713	Uncharacterized Staphylococcus aureus AldA1 (SACOL0154) aldehyde dehydrogenase-like; Region: ALDH_StaphAldA1; cd07117
1261557000714	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1261557000715	NAD(P) binding site [chemical binding]; other site
1261557000716	catalytic residues [active]
1261557000717	L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066
1261557000718	L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291
1261557000719	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1261557000720	NAD binding site [chemical binding]; other site
1261557000721	dimer interface [polypeptide binding]; other site
1261557000722	substrate binding site [chemical binding]; other site
1261557000723	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
1261557000724	putative active site [active]
1261557000725	catalytic residue [active]
1261557000726	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
1261557000727	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
1261557000728	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1261557000729	ATP binding site [chemical binding]; other site
1261557000730	putative Mg++ binding site [ion binding]; other site
1261557000731	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1261557000732	nucleotide binding region [chemical binding]; other site
1261557000733	ATP-binding site [chemical binding]; other site
1261557000734	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
1261557000735	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
1261557000736	Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124
1261557000737	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1261557000738	RNA binding surface [nucleotide binding]; other site
1261557000739	hypothetical protein; Provisional; Region: PRK08582
1261557000740	S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692
1261557000741	RNA binding site [nucleotide binding]; other site
1261557000742	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
1261557000743	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
1261557000744	Ligand Binding Site [chemical binding]; other site
1261557000745	TilS substrate C-terminal domain; Region: TilS_C; smart00977
1261557000746	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1261557000747	active site
1261557000748	FtsH Extracellular; Region: FtsH_ext; pfam06480
1261557000749	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
1261557000750	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1261557000751	Walker A motif; other site
1261557000752	ATP binding site [chemical binding]; other site
1261557000753	Walker B motif; other site
1261557000754	arginine finger; other site
1261557000755	Peptidase family M41; Region: Peptidase_M41; pfam01434
1261557000756	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
1261557000757	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
1261557000758	dimerization interface [polypeptide binding]; other site
1261557000759	domain crossover interface; other site
1261557000760	redox-dependent activation switch; other site
1261557000761	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
1261557000762	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
1261557000763	FMN binding site [chemical binding]; other site
1261557000764	active site
1261557000765	catalytic residues [active]
1261557000766	substrate binding site [chemical binding]; other site
1261557000767	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
1261557000768	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
1261557000769	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
1261557000770	dimer interface [polypeptide binding]; other site
1261557000771	putative anticodon binding site; other site
1261557000772	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
1261557000773	motif 1; other site
1261557000774	active site
1261557000775	motif 2; other site
1261557000776	motif 3; other site
1261557000777	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
1261557000778	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
1261557000779	HPr interaction site; other site
1261557000780	glycerol kinase (GK) interaction site [polypeptide binding]; other site
1261557000781	active site
1261557000782	phosphorylation site [posttranslational modification]
1261557000783	6-phospho-beta-glucosidase; Reviewed; Region: arb; PRK09593
1261557000784	beta-galactosidase; Region: BGL; TIGR03356
1261557000785	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046
1261557000786	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1261557000787	catalytic core [active]
1261557000788	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1261557000789	Transposase, Mutator family; Region: Transposase_mut; pfam00872
1261557000790	MULE transposase domain; Region: MULE; pfam10551
1261557000791	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
1261557000792	Helix-turn-helix domain; Region: HTH_38; pfam13936
1261557000793	Integrase core domain; Region: rve; pfam00665
1261557000794	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
1261557000795	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169
1261557000796	Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805
1261557000797	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1261557000798	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1261557000799	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
1261557000800	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
1261557000801	DNA binding site [nucleotide binding]
1261557000802	active site
1261557000803	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
1261557000804	Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418
1261557000805	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1261557000806	Zn2+ binding site [ion binding]; other site
1261557000807	Mg2+ binding site [ion binding]; other site
1261557000808	Cation efflux family; Region: Cation_efflux; pfam01545
1261557000809	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK06079
1261557000810	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
1261557000811	NAD binding site [chemical binding]; other site
1261557000812	homotetramer interface [polypeptide binding]; other site
1261557000813	homodimer interface [polypeptide binding]; other site
1261557000814	substrate binding site [chemical binding]; other site
1261557000815	active site
1261557000816	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
1261557000817	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
1261557000818	dimer interface [polypeptide binding]; other site
1261557000819	active site
1261557000820	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
1261557000821	dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037
1261557000822	Dihydroorotate dehydrogenase (DHOD) class 1A FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1A_like; cd04741
1261557000823	active site
1261557000824	FMN binding site [chemical binding]; other site
1261557000825	substrate binding site [chemical binding]; other site
1261557000826	catalytic residues [active]
1261557000827	homodimer interface [polypeptide binding]; other site
1261557000828	Fibronectin-binding protein (FBP); Region: FBP; pfam07299
1261557000829	elongation factor P; Validated; Region: PRK00529
1261557000830	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
1261557000831	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
1261557000832	RNA binding site [nucleotide binding]; other site
1261557000833	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
1261557000834	RNA binding site [nucleotide binding]; other site
1261557000835	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
1261557000836	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
1261557000837	dimer interface [polypeptide binding]; other site
1261557000838	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1261557000839	catalytic residue [active]
1261557000840	cystathionine gamma-synthase/cystathionine beta-lyase; Validated; Region: PRK06176
1261557000841	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
1261557000842	homodimer interface [polypeptide binding]; other site
1261557000843	substrate-cofactor binding pocket; other site
1261557000844	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1261557000845	catalytic residue [active]
1261557000846	6-phospho-beta-glucosidase; Reviewed; Region: celA; PRK09589
1261557000847	beta-galactosidase; Region: BGL; TIGR03356
1261557000848	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
1261557000849	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
1261557000850	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
1261557000851	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
1261557000852	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
1261557000853	putative active site [active]
1261557000854	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
1261557000855	RibD C-terminal domain; Region: RibD_C; cl17279
1261557000856	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
1261557000857	Cation transport protein; Region: TrkH; pfam02386
1261557000858	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
1261557000859	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
1261557000860	copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698
1261557000861	Penicillinase repressor; Region: Pencillinase_R; pfam03965
1261557000862	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
1261557000863	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
1261557000864	metal-binding site [ion binding]
1261557000865	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
1261557000866	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
1261557000867	metal-binding site [ion binding]
1261557000868	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1261557000869	Soluble P-type ATPase [General function prediction only]; Region: COG4087
1261557000870	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
1261557000871	metal-binding site [ion binding]
1261557000872	Predicted membrane protein [General function prediction only]; Region: COG4194
1261557000873	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1261557000874	DNA-binding site [nucleotide binding]; DNA binding site
1261557000875	Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585
1261557000876	trimer interface [polypeptide binding]; other site
1261557000877	active site
1261557000878	G bulge; other site
1261557000879	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
1261557000880	N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
1261557000881	Zn binding site [ion binding]; other site
1261557000882	C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347
1261557000883	Zn binding site [ion binding]; other site
1261557000884	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
1261557000885	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
1261557000886	GH18 domain of Chitinase D (ChiD).  ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins.  The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18; Region: GH18_chitinase_D-like; cd02871
1261557000887	Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704
1261557000888	putative active site [active]
1261557000889	Chitin binding domain; Region: Chitin_bind_3; pfam03067
1261557000890	Acyl-ACP thioesterase; Region: Acyl-ACP_TE; pfam01643
1261557000891	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
1261557000892	active site
1261557000893	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
1261557000894	active site
1261557000895	Protein of unknown function DUF72; Region: DUF72; pfam01904
1261557000896	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4696
1261557000897	metal binding site [ion binding]; metal-binding site
1261557000898	aspartate kinase; Reviewed; Region: PRK09034
1261557000899	AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245
1261557000900	putative catalytic residues [active]
1261557000901	putative nucleotide binding site [chemical binding]; other site
1261557000902	putative aspartate binding site [chemical binding]; other site
1261557000903	ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911
1261557000904	allosteric regulatory residue; other site
1261557000905	ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916
1261557000906	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
1261557000907	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1261557000908	motif II; other site
1261557000909	Septation ring formation regulator, EzrA; Region: EzrA; pfam06160
1261557000910	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
1261557000911	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
1261557000912	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1261557000913	catalytic residue [active]
1261557000914	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1261557000915	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1261557000916	active site
1261557000917	phosphorylation site [posttranslational modification]
1261557000918	intermolecular recognition site; other site
1261557000919	dimerization interface [polypeptide binding]; other site
1261557000920	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1261557000921	DNA binding site [nucleotide binding]
1261557000922	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1261557000923	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1261557000924	dimer interface [polypeptide binding]; other site
1261557000925	phosphorylation site [posttranslational modification]
1261557000926	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1261557000927	ATP binding site [chemical binding]; other site
1261557000928	Mg2+ binding site [ion binding]; other site
1261557000929	G-X-G motif; other site
1261557000930	Ankyrin repeats (many copies); Region: Ank_4; pfam13637
1261557000931	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
1261557000932	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
1261557000933	putative deaminase; Validated; Region: PRK06846
1261557000934	Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293
1261557000935	active site
1261557000936	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
1261557000937	Purine catabolism regulatory protein-like family; Region: PucR; pfam07905
1261557000938	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
1261557000939	membrane protein FdrA; Validated; Region: PRK06091
1261557000940	CoA binding domain; Region: CoA_binding; pfam02629
1261557000941	CoA-ligase; Region: Ligase_CoA; pfam00549
1261557000942	Protein of unknown function (DUF1116); Region: DUF1116; pfam06545
1261557000943	Protein of unknown function (DUF2877); Region: DUF2877; pfam11392
1261557000944	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1261557000945	D-galactonate transporter; Region: 2A0114; TIGR00893
1261557000946	putative substrate translocation pore; other site
1261557000947	carbamate kinase; Reviewed; Region: PRK12686
1261557000948	AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235
1261557000949	putative substrate binding site [chemical binding]; other site
1261557000950	nucleotide binding site [chemical binding]; other site
1261557000951	nucleotide binding site [chemical binding]; other site
1261557000952	homodimer interface [polypeptide binding]; other site
1261557000953	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
1261557000954	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
1261557000955	Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900
1261557000956	cytosine deaminase; Provisional; Region: PRK05985
1261557000957	Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293
1261557000958	active site
1261557000959	WxL domain surface cell wall-binding; Region: WxL; pfam13731
1261557000960	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883
1261557000961	TATA element modulatory factor 1 DNA binding; Region: TMF_DNA_bd; pfam12329
1261557000962	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
1261557000963	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
1261557000964	substrate binding site [chemical binding]; other site
1261557000965	THF binding site; other site
1261557000966	zinc-binding site [ion binding]; other site
1261557000967	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
1261557000968	Domain of unknown function DUF20; Region: UPF0118; pfam01594
1261557000969	Short repeat of unknown function (DUF308); Region: DUF308; cl15828
1261557000970	Protein of unknown function (DUF969); Region: DUF969; pfam06149
1261557000971	Predicted membrane protein [Function unknown]; Region: COG3817
1261557000972	Protein of unknown function (DUF979); Region: DUF979; pfam06166
1261557000973	Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I:  Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501
1261557000974	putative substrate binding pocket [chemical binding]; other site
1261557000975	AC domain interface; other site
1261557000976	catalytic triad [active]
1261557000977	AB domain interface; other site
1261557000978	interchain disulfide; other site
1261557000979	Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931
1261557000980	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1261557000981	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1261557000982	putative DNA binding site [nucleotide binding]; other site
1261557000983	putative Zn2+ binding site [ion binding]; other site
1261557000984	Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137
1261557000985	dimer interface [polypeptide binding]; other site
1261557000986	FMN binding site [chemical binding]; other site
1261557000987	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1261557000988	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
1261557000989	active site
1261557000990	motif I; other site
1261557000991	motif II; other site
1261557000992	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1261557000993	Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213
1261557000994	PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851
1261557000995	PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567
1261557000996	active site
1261557000997	P-loop; other site
1261557000998	phosphorylation site [posttranslational modification]
1261557000999	PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014
1261557001000	active site
1261557001001	P-loop; other site
1261557001002	phosphorylation site [posttranslational modification]
1261557001003	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
1261557001004	PRD domain; Region: PRD; pfam00874
1261557001005	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
1261557001006	P-loop; other site
1261557001007	active site
1261557001008	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163
1261557001009	active site
1261557001010	phosphorylation site [posttranslational modification]
1261557001011	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1261557001012	active site
1261557001013	phosphorylation site [posttranslational modification]
1261557001014	Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213
1261557001015	PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851
1261557001016	PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567
1261557001017	active site
1261557001018	P-loop; other site
1261557001019	phosphorylation site [posttranslational modification]
1261557001020	PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567
1261557001021	active site
1261557001022	P-loop; other site
1261557001023	phosphorylation site [posttranslational modification]
1261557001024	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1261557001025	active site
1261557001026	phosphorylation site [posttranslational modification]
1261557001027	mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318
1261557001028	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
1261557001029	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
1261557001030	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
1261557001031	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1261557001032	NADH(P)-binding; Region: NAD_binding_10; pfam13460
1261557001033	NAD(P) binding site [chemical binding]; other site
1261557001034	active site
1261557001035	Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999
1261557001036	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1261557001037	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1261557001038	Walker A/P-loop; other site
1261557001039	ATP binding site [chemical binding]; other site
1261557001040	Q-loop/lid; other site
1261557001041	ABC transporter signature motif; other site
1261557001042	Walker B; other site
1261557001043	D-loop; other site
1261557001044	H-loop/switch region; other site
1261557001045	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1261557001046	FtsX-like permease family; Region: FtsX; pfam02687
1261557001047	TrbC/VIRB2 family; Region: TrbC; pfam04956
1261557001048	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
1261557001049	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1261557001050	putative substrate translocation pore; other site
1261557001051	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1261557001052	Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105
1261557001053	DNA binding residues [nucleotide binding]
1261557001054	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
1261557001055	putative dimer interface [polypeptide binding]; other site
1261557001056	Transcriptional regulator [Transcription]; Region: IclR; COG1414
1261557001057	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
1261557001058	Bacterial transcriptional regulator; Region: IclR; pfam01614
1261557001059	2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800
1261557001060	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
1261557001061	active site
1261557001062	intersubunit interface [polypeptide binding]; other site
1261557001063	catalytic residue [active]
1261557001064	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1261557001065	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
1261557001066	substrate binding site [chemical binding]; other site
1261557001067	ATP binding site [chemical binding]; other site
1261557001068	5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924
1261557001069	gluconate 5-dehydrogenase; Provisional; Region: PRK07097
1261557001070	gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347
1261557001071	NADP binding site [chemical binding]; other site
1261557001072	homodimer interface [polypeptide binding]; other site
1261557001073	active site
1261557001074	Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470
1261557001075	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
1261557001076	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
1261557001077	TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090
1261557001078	DctM-like transporters; Region: DctM; pfam06808
1261557001079	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
1261557001080	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1261557001081	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1261557001082	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1261557001083	L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771
1261557001084	N- and C-terminal domain interface [polypeptide binding]; other site
1261557001085	rhamnulokinase; Region: rhamnulo_kin; TIGR02627
1261557001086	active site
1261557001087	putative catalytic site [active]
1261557001088	metal binding site [ion binding]; metal-binding site
1261557001089	ATP binding site [chemical binding]; other site
1261557001090	carbohydrate binding site [chemical binding]; other site
1261557001091	L-rhamnose isomerase; Provisional; Region: PRK01076
1261557001092	rhamnulose-1-phosphate aldolase; Region: rhamnu_1P_ald; TIGR02624
1261557001093	intersubunit interface [polypeptide binding]; other site
1261557001094	active site
1261557001095	Zn2+ binding site [ion binding]; other site
1261557001096	Domain of unknown function (DUF718); Region: DUF718; cl01281
1261557001097	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1261557001098	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1261557001099	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1261557001100	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
1261557001101	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
1261557001102	Metal-binding active site; metal-binding site
1261557001103	amino acid/peptide transporter (Peptide:H+ symporter), bacterial; Region: yjdL_sub1_fam; TIGR00924
1261557001104	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1261557001105	putative substrate translocation pore; other site
1261557001106	POT family; Region: PTR2; pfam00854
1261557001107	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1261557001108	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
1261557001109	CoenzymeA binding site [chemical binding]; other site
1261557001110	subunit interaction site [polypeptide binding]; other site
1261557001111	PHB binding site; other site
1261557001112	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1261557001113	Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
1261557001114	substrate binding site [chemical binding]; other site
1261557001115	oxyanion hole (OAH) forming residues; other site
1261557001116	trimer interface [polypeptide binding]; other site
1261557001117	O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK03640
1261557001118	O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912
1261557001119	acyl-activating enzyme (AAE) consensus motif; other site
1261557001120	putative AMP binding site [chemical binding]; other site
1261557001121	putative active site [active]
1261557001122	putative CoA binding site [chemical binding]; other site
1261557001123	Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169
1261557001124	isochorismate synthases; Region: isochor_syn; TIGR00543
1261557001125	2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449
1261557001126	Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037
1261557001127	dimer interface [polypeptide binding]; other site
1261557001128	tetramer interface [polypeptide binding]; other site
1261557001129	PYR/PP interface [polypeptide binding]; other site
1261557001130	TPP binding site [chemical binding]; other site
1261557001131	Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009
1261557001132	TPP-binding site; other site
1261557001133	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1261557001134	2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695
1261557001135	N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317
1261557001136	o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928
1261557001137	active site
1261557001138	octamer interface [polypeptide binding]; other site
1261557001139	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
1261557001140	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
1261557001141	active site
1261557001142	trimer interface [polypeptide binding]; other site
1261557001143	allosteric site; other site
1261557001144	hexamer (dimer of trimers) interface [polypeptide binding]; other site
1261557001145	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
1261557001146	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1261557001147	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1261557001148	acyl-activating enzyme (AAE) consensus motif; other site
1261557001149	acyl-activating enzyme (AAE) consensus motif; other site
1261557001150	AMP binding site [chemical binding]; other site
1261557001151	active site
1261557001152	CoA binding site [chemical binding]; other site
1261557001153	peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561
1261557001154	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
1261557001155	PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609
1261557001156	PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613
1261557001157	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
1261557001158	active site
1261557001159	phosphorylation site [posttranslational modification]
1261557001160	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11557
1261557001161	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
1261557001162	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
1261557001163	putative active site [active]
1261557001164	N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: PRK12570
1261557001165	N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007
1261557001166	putative active site [active]
1261557001167	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1261557001168	Beta-lactamase; Region: Beta-lactamase; pfam00144
1261557001169	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025
1261557001170	active pocket/dimerization site; other site
1261557001171	active site
1261557001172	phosphorylation site [posttranslational modification]
1261557001173	Protein of unknown function (DUF1189); Region: DUF1189; pfam06691
1261557001174	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
1261557001175	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
1261557001176	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
1261557001177	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
1261557001178	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
1261557001179	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
1261557001180	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581
1261557001181	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
1261557001182	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
1261557001183	active site
1261557001184	trimer interface [polypeptide binding]; other site
1261557001185	allosteric site; other site
1261557001186	active site lid [active]
1261557001187	hexamer (dimer of trimers) interface [polypeptide binding]; other site
1261557001188	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
1261557001189	MgtC family; Region: MgtC; pfam02308
1261557001190	Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704
1261557001191	Repair protein; Region: Repair_PSII; pfam04536
1261557001192	ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966
1261557001193	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
1261557001194	dimer interface [polypeptide binding]; other site
1261557001195	putative radical transfer pathway; other site
1261557001196	diiron center [ion binding]; other site
1261557001197	tyrosyl radical; other site
1261557001198	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07306
1261557001199	Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343
1261557001200	Class I ribonucleotide reductase; Region: RNR_I; cd01679
1261557001201	active site
1261557001202	dimer interface [polypeptide binding]; other site
1261557001203	catalytic residues [active]
1261557001204	effector binding site; other site
1261557001205	R2 peptide binding site; other site
1261557001206	ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600
1261557001207	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
1261557001208	catalytic residues [active]
1261557001209	Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918
1261557001210	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
1261557001211	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
1261557001212	G1 box; other site
1261557001213	GTP/Mg2+ binding site [chemical binding]; other site
1261557001214	Switch I region; other site
1261557001215	G2 box; other site
1261557001216	G3 box; other site
1261557001217	Switch II region; other site
1261557001218	G4 box; other site
1261557001219	G5 box; other site
1261557001220	Nucleoside recognition; Region: Gate; pfam07670
1261557001221	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
1261557001222	Nucleoside recognition; Region: Gate; pfam07670
1261557001223	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
1261557001224	Int/Topo IB signature motif; other site
1261557001225	Helix-turn-helix domain; Region: HTH_17; pfam12728
1261557001226	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
1261557001227	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1261557001228	DNA binding residues [nucleotide binding]
1261557001229	putative transposase OrfB; Reviewed; Region: PHA02517
1261557001230	Integrase core domain; Region: rve; pfam00665
1261557001231	Integrase core domain; Region: rve_2; pfam13333
1261557001232	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1261557001233	Transposase; Region: HTH_Tnp_1; pfam01527
1261557001234	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
1261557001235	Zeta toxin; Region: Zeta_toxin; pfam06414
1261557001236	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185
1261557001237	Bacterial epsilon antitoxin; Region: Epsilon_antitox; pfam08998
1261557001238	Omega Transcriptional Repressor; Region: Omega_Repress; pfam07764
1261557001239	CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656
1261557001240	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1261557001241	P-loop; other site
1261557001242	Magnesium ion binding site [ion binding]; other site
1261557001243	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1261557001244	Magnesium ion binding site [ion binding]; other site
1261557001245	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
1261557001246	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
1261557001247	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
1261557001248	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1261557001249	DNA-binding site [nucleotide binding]; DNA binding site
1261557001250	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
1261557001251	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
1261557001252	Helix-turn-helix domain; Region: HTH_38; pfam13936
1261557001253	Integrase core domain; Region: rve; pfam00665
1261557001254	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
1261557001255	Integrase core domain; Region: rve; pfam00665
1261557001256	PcfJ-like protein; Region: PcfJ; pfam14284
1261557001257	Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432
1261557001258	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03815
1261557001259	Protein of unknown function (DUF3991); Region: DUF3991; pfam13154
1261557001260	Toprim-like; Region: Toprim_2; pfam13155
1261557001261	Domain of unknown function (DUF1738); Region: DUF1738; pfam08401
1261557001262	Domain of unknown function (DUF955); Region: DUF955; cl01076
1261557001263	Type IV secretory system Conjugative DNA transfer; Region: T4SS-DNA_transf; pfam02534
1261557001264	TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696
1261557001265	Protein of unknown function (DUF3801); Region: DUF3801; pfam12687
1261557001266	AAA domain; Region: AAA_13; pfam13166
1261557001267	CHAP domain; Region: CHAP; pfam05257
1261557001268	AAA-like domain; Region: AAA_10; pfam12846
1261557001269	PrgU-like protein; Region: PrgU; pfam09627
1261557001270	Glucan-binding protein C; Region: GbpC; pfam08363
1261557001271	adhesin isopeptide-forming domain, sspB-C2 type; Region: isopep_sspB_C2; TIGR04228
1261557001272	adhesin isopeptide-forming domain, sspB-C2 type; Region: isopep_sspB_C2; TIGR04228
1261557001273	Gram positive anchor; Region: Gram_pos_anchor; pfam00746
1261557001274	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1261557001275	Transposase; Region: HTH_Tnp_1; pfam01527
1261557001276	putative transposase OrfB; Reviewed; Region: PHA02517
1261557001277	HTH-like domain; Region: HTH_21; pfam13276
1261557001278	Integrase core domain; Region: rve; pfam00665
1261557001279	Integrase core domain; Region: rve_2; pfam13333
1261557001280	Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641
1261557001281	Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303
1261557001282	2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522
1261557001283	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
1261557001284	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
1261557001285	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1261557001286	active site
1261557001287	DNA binding site [nucleotide binding]
1261557001288	Int/Topo IB signature motif; other site
1261557001289	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
1261557001290	Integrase core domain; Region: rve; pfam00665
1261557001291	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
1261557001292	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
1261557001293	catalytic residues [active]
1261557001294	catalytic nucleophile [active]
1261557001295	Presynaptic Site I dimer interface [polypeptide binding]; other site
1261557001296	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
1261557001297	Synaptic Flat tetramer interface [polypeptide binding]; other site
1261557001298	Synaptic Site I dimer interface [polypeptide binding]; other site
1261557001299	DNA binding site [nucleotide binding]
1261557001300	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1261557001301	putative substrate translocation pore; other site
1261557001302	multicopper oxidase; Provisional; Region: PRK10965
1261557001303	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
1261557001304	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
1261557001305	Integrase core domain; Region: rve; pfam00665
1261557001306	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
1261557001307	Helix-turn-helix domain; Region: HTH_38; pfam13936
1261557001308	D-lactate dehydrogenase; Provisional; Region: PRK11183
1261557001309	D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330
1261557001310	putative transposase OrfB; Reviewed; Region: PHA02517
1261557001311	HTH-like domain; Region: HTH_21; pfam13276
1261557001312	Integrase core domain; Region: rve; pfam00665
1261557001313	Integrase core domain; Region: rve_2; pfam13333
1261557001314	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1261557001315	Helix-turn-helix domain; Region: HTH_28; pfam13518
1261557001316	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1261557001317	Homeodomain-like domain; Region: HTH_23; cl17451
1261557001318	pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK07251
1261557001319	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1261557001320	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1261557001321	Isochorismatase family; Region: Isochorismatase; pfam00857
1261557001322	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
1261557001323	catalytic triad [active]
1261557001324	conserved cis-peptide bond; other site
1261557001325	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1261557001326	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1261557001327	Transposase; Region: DDE_Tnp_ISL3; pfam01610
1261557001328	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
1261557001329	Transposase; Region: DDE_Tnp_ISL3; pfam01610
1261557001330	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
1261557001331	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1261557001332	Transposase, Mutator family; Region: Transposase_mut; pfam00872
1261557001333	MULE transposase domain; Region: MULE; pfam10551
1261557001334	LexA repressor; Validated; Region: PRK00215
1261557001335	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1261557001336	non-specific DNA binding site [nucleotide binding]; other site
1261557001337	salt bridge; other site
1261557001338	sequence-specific DNA binding site [nucleotide binding]; other site
1261557001339	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1261557001340	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
1261557001341	Walker A motif; other site
1261557001342	ATP binding site [chemical binding]; other site
1261557001343	Walker B motif; other site
1261557001344	arginine finger; other site
1261557001345	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1261557001346	Walker A motif; other site
1261557001347	ATP binding site [chemical binding]; other site
1261557001348	Walker B motif; other site
1261557001349	arginine finger; other site
1261557001350	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
1261557001351	MULE transposase domain; Region: MULE; pfam10551
1261557001352	Transposase, Mutator family; Region: Transposase_mut; pfam00872
1261557001353	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
1261557001354	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
1261557001355	Helix-turn-helix domain; Region: HTH_38; pfam13936
1261557001356	Uncharacterized ACR, COG2135; Region: DUF159; pfam02586
1261557001357	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
1261557001358	Helix-turn-helix domain; Region: HTH_38; pfam13936
1261557001359	Integrase core domain; Region: rve; pfam00665
1261557001360	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
1261557001361	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1261557001362	Magnesium ion binding site [ion binding]; other site
1261557001363	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
1261557001364	domain II; other site
1261557001365	domain III; other site
1261557001366	nucleotide binding site [chemical binding]; other site
1261557001367	DNA binding groove [nucleotide binding]
1261557001368	catalytic site [active]
1261557001369	domain IV; other site
1261557001370	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
1261557001371	C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342
1261557001372	putative transposase OrfB; Reviewed; Region: PHA02517
1261557001373	HTH-like domain; Region: HTH_21; pfam13276
1261557001374	Integrase core domain; Region: rve; pfam00665
1261557001375	Integrase core domain; Region: rve_2; pfam13333
1261557001376	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1261557001377	Transposase; Region: HTH_Tnp_1; pfam01527
1261557001378	CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656
1261557001379	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1261557001380	P-loop; other site
1261557001381	Magnesium ion binding site [ion binding]; other site
1261557001382	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1261557001383	Magnesium ion binding site [ion binding]; other site
1261557001384	Omega Transcriptional Repressor; Region: Omega_Repress; pfam07764
1261557001385	Bacterial epsilon antitoxin; Region: Epsilon_antitox; pfam08998
1261557001386	Circularly permuted YlqF-related GTPases; Region: YlqF_related_GTPase; cl17249
1261557001387	GTP/Mg2+ binding site [chemical binding]; other site
1261557001388	G5 box; other site
1261557001389	G1 box; other site
1261557001390	Switch I region; other site
1261557001391	G2 box; other site
1261557001392	G3 box; other site
1261557001393	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
1261557001394	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
1261557001395	motif II; other site
1261557001396	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
1261557001397	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
1261557001398	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
1261557001399	galactose-6-phosphate isomerase subunit LacA; Reviewed; Region: PRK08621
1261557001400	galactose-6-phosphate isomerase subunit LacB; Reviewed; Region: PRK08622
1261557001401	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
1261557001402	tagatose-6-phosphate kinase; Region: lacC; TIGR01231
1261557001403	putative substrate binding site [chemical binding]; other site
1261557001404	putative ATP binding site [chemical binding]; other site
1261557001405	tagatose 1,6-diphosphate aldolase; Reviewed; Region: PRK12399
1261557001406	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
1261557001407	methionine cluster; other site
1261557001408	active site
1261557001409	phosphorylation site [posttranslational modification]
1261557001410	metal binding site [ion binding]; metal-binding site
1261557001411	phosphotransferase system, lactose specific, IIC component; Region: lac_pts_IIC; TIGR00394
1261557001412	Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378
1261557001413	PTS_IIB_lactose: subunit IIB of enzyme II (EII) of the lactose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS) found in Firmicutes as well as Actinobacteria. In this system, EII is a lactose-specific permease with two...; Region: PTS_IIB_lactose; cd05565
1261557001414	active site
1261557001415	P-loop; other site
1261557001416	phosphorylation site [posttranslational modification]
1261557001417	6-phospho-beta-galactosidase; Provisional; Region: PRK13511
1261557001418	beta-galactosidase; Region: BGL; TIGR03356
1261557001419	Protein of unknown function (DUF3884); Region: DUF3884; pfam13024
1261557001420	Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024
1261557001421	active site
1261557001422	catalytic residues [active]
1261557001423	Zeta toxin; Region: Zeta_toxin; pfam06414
1261557001424	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
1261557001425	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
1261557001426	catalytic residues [active]
1261557001427	catalytic nucleophile [active]
1261557001428	Domain of unknown function (DUF4158); Region: DUF4158; pfam13700
1261557001429	Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526
1261557001430	Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275
1261557001431	Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins.  PVA has an N-terminal...; Region: Ntn_PVA; cd00542
1261557001432	active site
1261557001433	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
1261557001434	Integrase core domain; Region: rve; pfam00665
1261557001435	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1261557001436	active site
1261557001437	phosphorylation site [posttranslational modification]
1261557001438	PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563
1261557001439	PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451
1261557001440	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138
1261557001441	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
1261557001442	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1261557001443	catalytic core [active]
1261557001444	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1261557001445	ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872
1261557001446	Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025
1261557001447	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
1261557001448	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
1261557001449	DDE superfamily endonuclease; Region: DDE_3; pfam13358
1261557001450	putative septicolysin, cholesterol-dependent cytolysin family and related proteins; Region: septicolysin_like; cd12208
1261557001451	oligomer interface [polypeptide binding]; other site
1261557001452	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
1261557001453	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
1261557001454	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
1261557001455	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
1261557001456	Integrase core domain; Region: rve; pfam00665
1261557001457	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
1261557001458	Helix-turn-helix domain; Region: HTH_38; pfam13936
1261557001459	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1261557001460	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1261557001461	active site
1261557001462	catalytic tetrad [active]
1261557001463	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1261557001464	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
1261557001465	active site
1261557001466	metal binding site [ion binding]; metal-binding site
1261557001467	cardiolipin synthase; Region: bac_cardiolipin; TIGR04265
1261557001468	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
1261557001469	putative active site [active]
1261557001470	catalytic site [active]
1261557001471	catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112
1261557001472	putative active site [active]
1261557001473	catalytic site [active]
1261557001474	tyrosyl-tRNA synthetase; Provisional; Region: PRK13354
1261557001475	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
1261557001476	active site
1261557001477	HIGH motif; other site
1261557001478	dimer interface [polypeptide binding]; other site
1261557001479	KMSKS motif; other site
1261557001480	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1261557001481	RNA binding surface [nucleotide binding]; other site
1261557001482	tyrosine decarboxylase, Enterococcus type; Region: tyr_de_CO2_Ent; TIGR03811
1261557001483	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1261557001484	catalytic residue [active]
1261557001485	putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813
1261557001486	Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931
1261557001487	Protein of unknown function (DUF1307); Region: DUF1307; pfam06998
1261557001488	Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971
1261557001489	tetramer interfaces [polypeptide binding]; other site
1261557001490	binuclear metal-binding site [ion binding]; other site
1261557001491	L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291
1261557001492	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1261557001493	L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771
1261557001494	NAD binding site [chemical binding]; other site
1261557001495	dimer interface [polypeptide binding]; other site
1261557001496	substrate binding site [chemical binding]; other site
1261557001497	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1261557001498	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1261557001499	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1261557001500	dimerization interface [polypeptide binding]; other site
1261557001501	Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275
1261557001502	C4-dicarboxylate transporters of the Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_C4-dicarb_trans; cd09325
1261557001503	gating phenylalanine in ion channel; other site
1261557001504	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1261557001505	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1261557001506	NAD(P) binding site [chemical binding]; other site
1261557001507	active site
1261557001508	Predicted transcriptional regulators [Transcription]; Region: COG1733
1261557001509	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
1261557001510	Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137
1261557001511	dimer interface [polypeptide binding]; other site
1261557001512	FMN binding site [chemical binding]; other site
1261557001513	lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545
1261557001514	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
1261557001515	Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437
1261557001516	Peptidase family M48; Region: Peptidase_M48; cl12018
1261557001517	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1261557001518	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1261557001519	DNA binding site [nucleotide binding]
1261557001520	domain linker motif; other site
1261557001521	Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286
1261557001522	putative dimerization interface [polypeptide binding]; other site
1261557001523	putative ligand binding site [chemical binding]; other site
1261557001524	Nitroreductase-like family 4.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140
1261557001525	dimer interface [polypeptide binding]; other site
1261557001526	FMN binding site [chemical binding]; other site
1261557001527	Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514
1261557001528	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255
1261557001529	putative metal binding site [ion binding]; other site
1261557001530	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
1261557001531	active site
1261557001532	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
1261557001533	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
1261557001534	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
1261557001535	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
1261557001536	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
1261557001537	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066
1261557001538	active site
1261557001539	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
1261557001540	active site
1261557001541	Fe-S cluster binding site [ion binding]; other site
1261557001542	multidrug efflux pump VmrA; Reviewed; Region: vmrA; PRK09575
1261557001543	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143
1261557001544	oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290
1261557001545	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_2; cd09607
1261557001546	active site
1261557001547	Zn binding site [ion binding]; other site
1261557001548	Predicted integral membrane protein [Function unknown]; Region: COG5652
1261557001549	hypothetical protein; Validated; Region: PRK00110
1261557001550	C_GCAxxG_C_C family probable redox protein; Region: C_GCAxxG_C_C; TIGR01909
1261557001551	N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
1261557001552	C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347
1261557001553	Zn binding site [ion binding]; other site
1261557001554	putative hydrolase; Provisional; Region: PRK11460
1261557001555	Predicted esterase [General function prediction only]; Region: COG0400
1261557001556	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
1261557001557	active site
1261557001558	catalytic motif [active]
1261557001559	Zn binding site [ion binding]; other site
1261557001560	UDP-N-acetylmuramoylalanyl-D-glutamate--L-lysine ligase; Provisional; Region: PRK14022
1261557001561	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
1261557001562	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1261557001563	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1261557001564	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
1261557001565	Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124
1261557001566	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
1261557001567	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1261557001568	RNA binding surface [nucleotide binding]; other site
1261557001569	Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553
1261557001570	active site
1261557001571	uracil binding [chemical binding]; other site
1261557001572	dipeptidase PepV; Region: dipeptidase; TIGR01886
1261557001573	M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888
1261557001574	active site
1261557001575	metal binding site [ion binding]; metal-binding site
1261557001576	DNA primase large subunit; Validated; Region: PRK03968
1261557001577	Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594
1261557001578	Acyltransferase family; Region: Acyl_transf_3; pfam01757
1261557001579	ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125
1261557001580	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1261557001581	Walker A/P-loop; other site
1261557001582	ATP binding site [chemical binding]; other site
1261557001583	Q-loop/lid; other site
1261557001584	ABC transporter signature motif; other site
1261557001585	Walker B; other site
1261557001586	D-loop; other site
1261557001587	H-loop/switch region; other site
1261557001588	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1261557001589	ABC-ATPase subunit interface; other site
1261557001590	Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732
1261557001591	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891
1261557001592	Arginine repressor [Transcription]; Region: ArgR; COG1438
1261557001593	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
1261557001594	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
1261557001595	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
1261557001596	active site
1261557001597	substrate binding site [chemical binding]; other site
1261557001598	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
1261557001599	metal binding site [ion binding]; metal-binding site
1261557001600	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
1261557001601	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1261557001602	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
1261557001603	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
1261557001604	active site
1261557001605	Transglycosylase; Region: Transgly; pfam00912
1261557001606	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
1261557001607	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1261557001608	hypothetical protein; Provisional; Region: PRK13676
1261557001609	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
1261557001610	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1261557001611	active site
1261557001612	metal binding site [ion binding]; metal-binding site
1261557001613	DNA binding site [nucleotide binding]
1261557001614	Uncharacterized conserved protein [Function unknown]; Region: COG4717
1261557001615	Uncharacterized conserved protein [Function unknown]; Region: COG4717
1261557001616	3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480
1261557001617	YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492
1261557001618	generic binding surface II; other site
1261557001619	generic binding surface I; other site
1261557001620	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1261557001621	Zn2+ binding site [ion binding]; other site
1261557001622	Mg2+ binding site [ion binding]; other site
1261557001623	foldase protein PrsA; Reviewed; Region: prsA; PRK01326
1261557001624	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
1261557001625	HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277
1261557001626	HIT family signature motif; other site
1261557001627	catalytic residue [active]
1261557001628	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
1261557001629	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1261557001630	Walker A/P-loop; other site
1261557001631	ATP binding site [chemical binding]; other site
1261557001632	Q-loop/lid; other site
1261557001633	ABC transporter signature motif; other site
1261557001634	Walker B; other site
1261557001635	D-loop; other site
1261557001636	H-loop/switch region; other site
1261557001637	Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975
1261557001638	Thiamine kinase and related kinases [Coenzyme transport and metabolism]; Region: ycfN; COG0510
1261557001639	Phosphotransferase enzyme family; Region: APH; pfam01636
1261557001640	active site
1261557001641	substrate binding site [chemical binding]; other site
1261557001642	ATP binding site [chemical binding]; other site
1261557001643	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1261557001644	S-adenosylmethionine binding site [chemical binding]; other site
1261557001645	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
1261557001646	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
1261557001647	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
1261557001648	putative active site [active]
1261557001649	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
1261557001650	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
1261557001651	putative substrate binding site [chemical binding]; other site
1261557001652	putative ATP binding site [chemical binding]; other site
1261557001653	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
1261557001654	active site
1261557001655	P-loop; other site
1261557001656	phosphorylation site [posttranslational modification]
1261557001657	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
1261557001658	Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378
1261557001659	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1261557001660	active site
1261557001661	phosphorylation site [posttranslational modification]
1261557001662	Class I aldolases; Region: Aldolase_Class_I; cl17187
1261557001663	hypothetical protein; Provisional; Region: PRK13662
1261557001664	Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444
1261557001665	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1261557001666	Coenzyme A binding pocket [chemical binding]; other site
1261557001667	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
1261557001668	Domain of unknown function DUF20; Region: UPF0118; pfam01594
1261557001669	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
1261557001670	Domain of unknown function DUF21; Region: DUF21; pfam01595
1261557001671	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
1261557001672	Transporter associated domain; Region: CorC_HlyC; pfam03471
1261557001673	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
1261557001674	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
1261557001675	G1 box; other site
1261557001676	putative GEF interaction site [polypeptide binding]; other site
1261557001677	GTP/Mg2+ binding site [chemical binding]; other site
1261557001678	Switch I region; other site
1261557001679	G2 box; other site
1261557001680	G3 box; other site
1261557001681	Switch II region; other site
1261557001682	G4 box; other site
1261557001683	G5 box; other site
1261557001684	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
1261557001685	Protein of unknown function (DUF3290); Region: DUF3290; pfam11694
1261557001686	Predicted membrane protein [Function unknown]; Region: COG2323
1261557001687	Domain of unknown function (DUF1827); Region: DUF1827; pfam08860
1261557001688	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1261557001689	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
1261557001690	Walker A motif; other site
1261557001691	ATP binding site [chemical binding]; other site
1261557001692	Walker B motif; other site
1261557001693	arginine finger; other site
1261557001694	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1261557001695	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
1261557001696	Walker A motif; other site
1261557001697	ATP binding site [chemical binding]; other site
1261557001698	Walker B motif; other site
1261557001699	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
1261557001700	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
1261557001701	dimerization domain swap beta strand [polypeptide binding]; other site
1261557001702	regulatory protein interface [polypeptide binding]; other site
1261557001703	active site
1261557001704	regulatory phosphorylation site [posttranslational modification]; other site
1261557001705	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
1261557001706	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
1261557001707	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
1261557001708	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
1261557001709	Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030
1261557001710	Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797
1261557001711	WxL domain surface cell wall-binding; Region: WxL; pfam13731
1261557001712	trigger factor; Provisional; Region: tig; PRK01490
1261557001713	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
1261557001714	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
1261557001715	PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765
1261557001716	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1261557001717	active site
1261557001718	phosphorylation site [posttranslational modification]
1261557001719	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
1261557001720	active site
1261557001721	P-loop; other site
1261557001722	phosphorylation site [posttranslational modification]
1261557001723	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
1261557001724	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
1261557001725	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
1261557001726	putative substrate binding site [chemical binding]; other site
1261557001727	putative ATP binding site [chemical binding]; other site
1261557001728	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
1261557001729	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
1261557001730	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
1261557001731	ClC chloride channel EriC.  This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031
1261557001732	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
1261557001733	Cl- selectivity filter; other site
1261557001734	Cl- binding residues [ion binding]; other site
1261557001735	pore gating glutamate residue; other site
1261557001736	dimer interface [polypeptide binding]; other site
1261557001737	H+/Cl- coupling transport residue; other site
1261557001738	TrkA-C domain; Region: TrkA_C; pfam02080
1261557001739	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
1261557001740	Part of AAA domain; Region: AAA_19; pfam13245
1261557001741	Family description; Region: UvrD_C_2; pfam13538
1261557001742	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
1261557001743	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
1261557001744	nucleotide binding pocket [chemical binding]; other site
1261557001745	K-X-D-G motif; other site
1261557001746	catalytic site [active]
1261557001747	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
1261557001748	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
1261557001749	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
1261557001750	Dimer interface [polypeptide binding]; other site
1261557001751	BRCT sequence motif; other site
1261557001752	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
1261557001753	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
1261557001754	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
1261557001755	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
1261557001756	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
1261557001757	GatB domain; Region: GatB_Yqey; smart00845
1261557001758	putative lipid kinase; Reviewed; Region: PRK13055
1261557001759	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
1261557001760	TRAM domain; Region: TRAM; pfam01938
1261557001761	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
1261557001762	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1261557001763	S-adenosylmethionine binding site [chemical binding]; other site
1261557001764	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1261557001765	catalytic residues [active]
1261557001766	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1261557001767	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1261557001768	DNA binding residues [nucleotide binding]
1261557001769	dimerization interface [polypeptide binding]; other site
1261557001770	putrescine carbamoyltransferase; Provisional; Region: PRK02255
1261557001771	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
1261557001772	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
1261557001773	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
1261557001774	agmatine deiminase; Provisional; Region: PRK13551
1261557001775	agmatine deiminase; Region: agmatine_aguA; TIGR03380
1261557001776	carbamate kinase; Reviewed; Region: PRK12686
1261557001777	AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235
1261557001778	putative substrate binding site [chemical binding]; other site
1261557001779	nucleotide binding site [chemical binding]; other site
1261557001780	nucleotide binding site [chemical binding]; other site
1261557001781	homodimer interface [polypeptide binding]; other site
1261557001782	amidase; Provisional; Region: PRK06707
1261557001783	Amidase; Region: Amidase; cl11426
1261557001784	nicotinamide mononucleotide transporter PnuC; Region: NMN_trans_PnuC; TIGR01528
1261557001785	Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428
1261557001786	Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673
1261557001787	Substrate-binding site [chemical binding]; other site
1261557001788	Substrate specificity [chemical binding]; other site
1261557001789	Protein of unknown function (DUF1149); Region: DUF1149; pfam06619
1261557001790	Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823
1261557001791	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
1261557001792	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263
1261557001793	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1261557001794	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1261557001795	Beta-lactamase; Region: Beta-lactamase; pfam00144
1261557001796	Predicted membrane protein [Function unknown]; Region: COG4420
1261557001797	putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142
1261557001798	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
1261557001799	active site residue [active]
1261557001800	Protein of unknown function (DUF3650); Region: DUF3650; pfam12368
1261557001801	Gram positive anchor; Region: Gram_pos_anchor; pfam00746
1261557001802	WxL domain surface cell wall-binding; Region: WxL; pfam13731
1261557001803	WxL domain surface cell wall-binding; Region: WxL; pfam13731
1261557001804	legume lectins; Region: lectin_L-type; cd01951
1261557001805	homotetramer interaction site [polypeptide binding]; other site
1261557001806	homodimer interaction site [polypeptide binding]; other site
1261557001807	carbohydrate binding site [chemical binding]; other site
1261557001808	metal binding site [ion binding]; metal-binding site
1261557001809	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
1261557001810	WxL domain surface cell wall-binding; Region: WxL; pfam13731
1261557001811	Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030
1261557001812	Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797
1261557001813	Mga helix-turn-helix domain; Region: Mga; pfam05043
1261557001814	heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525
1261557001815	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1261557001816	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
1261557001817	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
1261557001818	MgtC family; Region: MgtC; pfam02308
1261557001819	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1261557001820	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1261557001821	Walker A/P-loop; other site
1261557001822	ATP binding site [chemical binding]; other site
1261557001823	Q-loop/lid; other site
1261557001824	ABC transporter signature motif; other site
1261557001825	Walker B; other site
1261557001826	D-loop; other site
1261557001827	H-loop/switch region; other site
1261557001828	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1261557001829	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1261557001830	substrate binding pocket [chemical binding]; other site
1261557001831	membrane-bound complex binding site; other site
1261557001832	hinge residues; other site
1261557001833	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1261557001834	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1261557001835	substrate binding pocket [chemical binding]; other site
1261557001836	membrane-bound complex binding site; other site
1261557001837	hinge residues; other site
1261557001838	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1261557001839	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1261557001840	dimer interface [polypeptide binding]; other site
1261557001841	conserved gate region; other site
1261557001842	putative PBP binding loops; other site
1261557001843	ABC-ATPase subunit interface; other site
1261557001844	excinuclease ABC subunit B; Provisional; Region: PRK05298
1261557001845	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1261557001846	ATP binding site [chemical binding]; other site
1261557001847	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1261557001848	nucleotide binding region [chemical binding]; other site
1261557001849	ATP-binding site [chemical binding]; other site
1261557001850	Ultra-violet resistance protein B; Region: UvrB; pfam12344
1261557001851	UvrB/uvrC motif; Region: UVR; pfam02151
1261557001852	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
1261557001853	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
1261557001854	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
1261557001855	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
1261557001856	YusW-like protein; Region: YusW; pfam14039
1261557001857	glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416
1261557001858	conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826
1261557001859	family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187
1261557001860	phosphate binding site [ion binding]; other site
1261557001861	putative substrate binding pocket [chemical binding]; other site
1261557001862	dimer interface [polypeptide binding]; other site
1261557001863	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481
1261557001864	Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298
1261557001865	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
1261557001866	Thioredoxin; Region: Thioredoxin_4; pfam13462
1261557001867	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
1261557001868	Clp protease; Region: CLP_protease; pfam00574
1261557001869	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
1261557001870	oligomer interface [polypeptide binding]; other site
1261557001871	active site residues [active]
1261557001872	Protein of unknown function (DUF1622); Region: DUF1622; pfam07784
1261557001873	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
1261557001874	metal ion-dependent adhesion site (MIDAS); other site
1261557001875	fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226
1261557001876	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
1261557001877	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
1261557001878	Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; pfam10110
1261557001879	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
1261557001880	Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579
1261557001881	putative active site [active]
1261557001882	catalytic site [active]
1261557001883	putative metal binding site [ion binding]; other site
1261557001884	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
1261557001885	nudix motif; other site
1261557001886	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
1261557001887	DNA-binding site [nucleotide binding]; DNA binding site
1261557001888	RNA-binding motif; other site
1261557001889	RNA polymerase sigma-54 factor; Region: rpoN_sigma; TIGR02395
1261557001890	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
1261557001891	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
1261557001892	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
1261557001893	yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840
1261557001894	catalytic triad [active]
1261557001895	catalytic triad [active]
1261557001896	oxyanion hole [active]
1261557001897	S-adenosylmethionine synthetase; Validated; Region: PRK05250
1261557001898	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
1261557001899	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
1261557001900	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
1261557001901	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1261557001902	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1261557001903	putative substrate translocation pore; other site
1261557001904	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1261557001905	Predicted esterase [General function prediction only]; Region: COG0627
1261557001906	S-formylglutathione hydrolase; Region: PLN02442
1261557001907	tetracycline repressor protein TetR; Provisional; Region: PRK13756
1261557001908	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1261557001909	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1261557001910	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1261557001911	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1261557001912	Walker A/P-loop; other site
1261557001913	ATP binding site [chemical binding]; other site
1261557001914	Q-loop/lid; other site
1261557001915	ABC transporter signature motif; other site
1261557001916	Walker B; other site
1261557001917	D-loop; other site
1261557001918	H-loop/switch region; other site
1261557001919	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1261557001920	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1261557001921	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
1261557001922	Walker A/P-loop; other site
1261557001923	ATP binding site [chemical binding]; other site
1261557001924	Q-loop/lid; other site
1261557001925	ABC transporter signature motif; other site
1261557001926	Walker B; other site
1261557001927	D-loop; other site
1261557001928	H-loop/switch region; other site
1261557001929	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1261557001930	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1261557001931	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1261557001932	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1261557001933	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1261557001934	Walker A/P-loop; other site
1261557001935	ATP binding site [chemical binding]; other site
1261557001936	Q-loop/lid; other site
1261557001937	ABC transporter signature motif; other site
1261557001938	Walker B; other site
1261557001939	D-loop; other site
1261557001940	H-loop/switch region; other site
1261557001941	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
1261557001942	Putative rRNA methylase; Region: rRNA_methylase; pfam06962
1261557001943	Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242
1261557001944	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
1261557001945	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
1261557001946	active site
1261557001947	Domain of unknown function (DUF4098); Region: DUF4098; pfam13345
1261557001948	Protein of unknown function (DUF1700); Region: DUF1700; pfam08006
1261557001949	Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705
1261557001950	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1261557001951	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1261557001952	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1261557001953	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1261557001954	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1261557001955	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1261557001956	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
1261557001957	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
1261557001958	HIGH motif; other site
1261557001959	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
1261557001960	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
1261557001961	active site
1261557001962	KMSKS motif; other site
1261557001963	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
1261557001964	tRNA binding surface [nucleotide binding]; other site
1261557001965	Protein of unknown function (DUF3955); Region: DUF3955; pfam13127
1261557001966	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1261557001967	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1261557001968	substrate binding pocket [chemical binding]; other site
1261557001969	membrane-bound complex binding site; other site
1261557001970	hinge residues; other site
1261557001971	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1261557001972	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1261557001973	Walker A/P-loop; other site
1261557001974	ATP binding site [chemical binding]; other site
1261557001975	Q-loop/lid; other site
1261557001976	ABC transporter signature motif; other site
1261557001977	Walker B; other site
1261557001978	D-loop; other site
1261557001979	H-loop/switch region; other site
1261557001980	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1261557001981	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1261557001982	dimer interface [polypeptide binding]; other site
1261557001983	conserved gate region; other site
1261557001984	putative PBP binding loops; other site
1261557001985	ABC-ATPase subunit interface; other site
1261557001986	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
1261557001987	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
1261557001988	peptide binding site [polypeptide binding]; other site
1261557001989	Transglycosylase associated protein; Region: Transgly_assoc; cl00978
1261557001990	Staphylococcal protein of unknown function (DUF960); Region: DUF960; pfam06124
1261557001991	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
1261557001992	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
1261557001993	5S rRNA interface [nucleotide binding]; other site
1261557001994	CTC domain interface [polypeptide binding]; other site
1261557001995	L16 interface [polypeptide binding]; other site
1261557001996	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
1261557001997	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1261557001998	RNA binding surface [nucleotide binding]; other site
1261557001999	Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553
1261557002000	active site
1261557002001	uracil binding [chemical binding]; other site
1261557002002	HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB
1261557002003	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1261557002004	motif II; other site
1261557002005	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1261557002006	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1261557002007	Coenzyme A binding pocket [chemical binding]; other site
1261557002008	Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572
1261557002009	Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023
1261557002010	Sugar specificity; other site
1261557002011	Pyrimidine base specificity; other site
1261557002012	ATP-binding site [chemical binding]; other site
1261557002013	PemK-like protein; Region: PemK; pfam02452
1261557002014	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1261557002015	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1261557002016	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
1261557002017	HTH domain; Region: HTH_11; pfam08279
1261557002018	HTH domain; Region: HTH_11; pfam08279
1261557002019	PRD domain; Region: PRD; pfam00874
1261557002020	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
1261557002021	active site
1261557002022	P-loop; other site
1261557002023	phosphorylation site [posttranslational modification]
1261557002024	PRD domain protein EF_0829/AHA_3910; Region: EF_0829; TIGR03582
1261557002025	Glycine-rich SFCGS; Region: Gly_rich_SFCGS; pfam14272
1261557002026	conserved hypothetical protein EF_0831/AHA_3912; Region: EF_0831; TIGR03578
1261557002027	Domain of unknown function (DUF4311); Region: DUF4311; cl11919
1261557002028	Domain of unknown function (DUF4310); Region: DUF4310; cl11918
1261557002029	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
1261557002030	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
1261557002031	Uncharacterized conserved protein [Function unknown]; Region: COG3589
1261557002032	Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913
1261557002033	probable amidohydrolase EF_0837/AHA_3915; Region: EF_0837; TIGR03583
1261557002034	Metallo-dependent hydrolases, subgroup B is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_B; cd01307
1261557002035	active site
1261557002036	uncharacterized pyridoxal phosphate-dependent enzyme; Region: selA_rel; TIGR01437
1261557002037	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1261557002038	catalytic residue [active]
1261557002039	conserved hypothetical protein EF_0839/AHA_3917; Region: EF_0839; TIGR03581
1261557002040	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1261557002041	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
1261557002042	substrate binding site [chemical binding]; other site
1261557002043	ATP binding site [chemical binding]; other site
1261557002044	DNA gyrase B; Region: DNA_gyraseB; pfam00204
1261557002045	ATP binding site [chemical binding]; other site
1261557002046	hypothetical protein; Validated; Region: PRK00124
1261557002047	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
1261557002048	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
1261557002049	D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478
1261557002050	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
1261557002051	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
1261557002052	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1261557002053	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1261557002054	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
1261557002055	DEAD-like helicases superfamily; Region: DEXDc; smart00487
1261557002056	ATP binding site [chemical binding]; other site
1261557002057	Mg++ binding site [ion binding]; other site
1261557002058	motif III; other site
1261557002059	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1261557002060	nucleotide binding region [chemical binding]; other site
1261557002061	ATP-binding site [chemical binding]; other site
1261557002062	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
1261557002063	alanine racemase; Reviewed; Region: alr; PRK00053
1261557002064	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
1261557002065	active site
1261557002066	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1261557002067	dimer interface [polypeptide binding]; other site
1261557002068	substrate binding site [chemical binding]; other site
1261557002069	catalytic residues [active]
1261557002070	PemK-like protein; Region: PemK; pfam02452
1261557002071	hypothetical protein; Provisional; Region: PRK11281
1261557002072	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
1261557002073	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
1261557002074	Catalytic site [active]
1261557002075	Mga helix-turn-helix domain; Region: Mga; pfam05043
1261557002076	Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350
1261557002077	Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348
1261557002078	Predicted membrane protein [Function unknown]; Region: COG1511
1261557002079	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
1261557002080	YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062
1261557002081	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
1261557002082	cation diffusion facilitator family transporter; Region: CDF; TIGR01297
1261557002083	Amino acid permease; Region: AA_permease_2; pfam13520
1261557002084	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1261557002085	Coenzyme A binding pocket [chemical binding]; other site
1261557002086	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1261557002087	dimer interface [polypeptide binding]; other site
1261557002088	conserved gate region; other site
1261557002089	putative PBP binding loops; other site
1261557002090	ABC-ATPase subunit interface; other site
1261557002091	Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732
1261557002092	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1261557002093	dimer interface [polypeptide binding]; other site
1261557002094	conserved gate region; other site
1261557002095	putative PBP binding loops; other site
1261557002096	ABC-ATPase subunit interface; other site
1261557002097	ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295
1261557002098	glycine betaine/L-proline transport ATP binding subunit; Region: proV; TIGR01186
1261557002099	Walker A/P-loop; other site
1261557002100	ATP binding site [chemical binding]; other site
1261557002101	Q-loop/lid; other site
1261557002102	ABC transporter signature motif; other site
1261557002103	Walker B; other site
1261557002104	D-loop; other site
1261557002105	H-loop/switch region; other site
1261557002106	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583
1261557002107	N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
1261557002108	Zn binding site [ion binding]; other site
1261557002109	C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347
1261557002110	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1261557002111	Zn binding site [ion binding]; other site
1261557002112	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
1261557002113	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
1261557002114	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1261557002115	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1261557002116	salt bridge; other site
1261557002117	non-specific DNA binding site [nucleotide binding]; other site
1261557002118	sequence-specific DNA binding site [nucleotide binding]; other site
1261557002119	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
1261557002120	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
1261557002121	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1261557002122	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
1261557002123	haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710
1261557002124	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
1261557002125	K+ potassium transporter; Region: K_trans; pfam02705
1261557002126	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1261557002127	non-specific DNA binding site [nucleotide binding]; other site
1261557002128	salt bridge; other site
1261557002129	sequence-specific DNA binding site [nucleotide binding]; other site
1261557002130	copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511
1261557002131	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1261557002132	Soluble P-type ATPase [General function prediction only]; Region: COG4087
1261557002133	Mga helix-turn-helix domain; Region: Mga; pfam05043
1261557002134	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1261557002135	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1261557002136	active site
1261557002137	catalytic tetrad [active]
1261557002138	DNA polymerase I; Provisional; Region: PRK05755
1261557002139	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
1261557002140	active site
1261557002141	metal binding site 1 [ion binding]; metal-binding site
1261557002142	putative 5' ssDNA interaction site; other site
1261557002143	metal binding site 3; metal-binding site
1261557002144	metal binding site 2 [ion binding]; metal-binding site
1261557002145	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
1261557002146	putative DNA binding site [nucleotide binding]; other site
1261557002147	putative metal binding site [ion binding]; other site
1261557002148	inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140
1261557002149	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
1261557002150	active site
1261557002151	DNA binding site [nucleotide binding]
1261557002152	catalytic site [active]
1261557002153	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
1261557002154	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
1261557002155	DNA binding site [nucleotide binding]
1261557002156	catalytic residue [active]
1261557002157	H2TH interface [polypeptide binding]; other site
1261557002158	putative catalytic residues [active]
1261557002159	turnover-facilitating residue; other site
1261557002160	intercalation triad [nucleotide binding]; other site
1261557002161	8OG recognition residue [nucleotide binding]; other site
1261557002162	putative reading head residues; other site
1261557002163	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
1261557002164	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
1261557002165	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
1261557002166	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
1261557002167	CoA-binding site [chemical binding]; other site
1261557002168	ATP-binding [chemical binding]; other site
1261557002169	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
1261557002170	ATP cone domain; Region: ATP-cone; pfam03477
1261557002171	Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611
1261557002172	primosomal protein DnaI; Reviewed; Region: PRK08939
1261557002173	Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319
1261557002174	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1261557002175	Walker A motif; other site
1261557002176	ATP binding site [chemical binding]; other site
1261557002177	Walker B motif; other site
1261557002178	Uncharacterized protein conserved in bacteria (DUF2334); Region: DUF2334; pfam10096
1261557002179	Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215
1261557002180	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
1261557002181	DXD motif; other site
1261557002182	Bacterial cellulose synthase subunit; Region: BcsB; cl15851
1261557002183	Bacterial cellulose synthase subunit; Region: BcsB; cl15851
1261557002184	aspartate aminotransferase; Provisional; Region: PRK06348
1261557002185	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1261557002186	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1261557002187	homodimer interface [polypeptide binding]; other site
1261557002188	catalytic residue [active]
1261557002189	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1261557002190	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1261557002191	Walker A/P-loop; other site
1261557002192	ATP binding site [chemical binding]; other site
1261557002193	Q-loop/lid; other site
1261557002194	ABC transporter signature motif; other site
1261557002195	Walker B; other site
1261557002196	D-loop; other site
1261557002197	H-loop/switch region; other site
1261557002198	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1261557002199	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1261557002200	substrate binding pocket [chemical binding]; other site
1261557002201	membrane-bound complex binding site; other site
1261557002202	hinge residues; other site
1261557002203	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1261557002204	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1261557002205	dimer interface [polypeptide binding]; other site
1261557002206	conserved gate region; other site
1261557002207	ABC-ATPase subunit interface; other site
1261557002208	Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371
1261557002209	Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172
1261557002210	putative active site [active]
1261557002211	metal binding site [ion binding]; metal-binding site
1261557002212	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
1261557002213	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
1261557002214	Preprotein translocase subunit; Region: YajC; pfam02699
1261557002215	Post-transcriptional regulator; Region: Post_transc_reg; pfam13797
1261557002216	bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805
1261557002217	Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122
1261557002218	putative catalytic cysteine [active]
1261557002219	C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178
1261557002220	putative active site [active]
1261557002221	metal binding site [ion binding]; metal-binding site
1261557002222	isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437
1261557002223	Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811
1261557002224	homotetramer interface [polypeptide binding]; other site
1261557002225	FMN binding site [chemical binding]; other site
1261557002226	homodimer contacts [polypeptide binding]; other site
1261557002227	putative active site [active]
1261557002228	putative substrate binding site [chemical binding]; other site
1261557002229	phosphomevalonate kinase, ERG8-type, Gram-positive branch; Region: Pmev_kin_Gr_pos; TIGR01220
1261557002230	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
1261557002231	diphosphomevalonate decarboxylase; Region: mevDPdecarb; TIGR01240
1261557002232	diphosphomevalonate decarboxylase; Region: PLN02407
1261557002233	mevalonate kinase; Region: mevalon_kin; TIGR00549
1261557002234	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
1261557002235	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
1261557002236	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
1261557002237	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
1261557002238	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
1261557002239	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
1261557002240	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
1261557002241	peptide binding site [polypeptide binding]; other site
1261557002242	Domain of unknown function (DUF3899); Region: DUF3899; pfam13038
1261557002243	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1261557002244	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1261557002245	dimer interface [polypeptide binding]; other site
1261557002246	conserved gate region; other site
1261557002247	putative PBP binding loops; other site
1261557002248	ABC-ATPase subunit interface; other site
1261557002249	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
1261557002250	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
1261557002251	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1261557002252	dimer interface [polypeptide binding]; other site
1261557002253	conserved gate region; other site
1261557002254	putative PBP binding loops; other site
1261557002255	ABC-ATPase subunit interface; other site
1261557002256	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
1261557002257	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1261557002258	Walker A/P-loop; other site
1261557002259	ATP binding site [chemical binding]; other site
1261557002260	Q-loop/lid; other site
1261557002261	ABC transporter signature motif; other site
1261557002262	Walker B; other site
1261557002263	D-loop; other site
1261557002264	H-loop/switch region; other site
1261557002265	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1261557002266	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
1261557002267	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1261557002268	Walker A/P-loop; other site
1261557002269	ATP binding site [chemical binding]; other site
1261557002270	Q-loop/lid; other site
1261557002271	ABC transporter signature motif; other site
1261557002272	Walker B; other site
1261557002273	D-loop; other site
1261557002274	H-loop/switch region; other site
1261557002275	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1261557002276	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
1261557002277	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
1261557002278	Probable transposase; Region: OrfB_IS605; pfam01385
1261557002279	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
1261557002280	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
1261557002281	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
1261557002282	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
1261557002283	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
1261557002284	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
1261557002285	23S rRNA binding site [nucleotide binding]; other site
1261557002286	L21 binding site [polypeptide binding]; other site
1261557002287	L13 binding site [polypeptide binding]; other site
1261557002288	Protein of unknown function (DUF419); Region: DUF419; pfam04237
1261557002289	Protein of unknown function (DUF1304); Region: DUF1304; pfam06993
1261557002290	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1261557002291	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
1261557002292	Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229
1261557002293	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
1261557002294	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
1261557002295	Sulfate transporter family; Region: Sulfate_transp; pfam00916
1261557002296	Predicted membrane protein [Function unknown]; Region: COG2855
1261557002297	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1261557002298	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1261557002299	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1261557002300	dimerization interface [polypeptide binding]; other site
1261557002301	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
1261557002302	dimer interface [polypeptide binding]; other site
1261557002303	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
1261557002304	dimer interface [polypeptide binding]; other site
1261557002305	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1261557002306	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1261557002307	active site
1261557002308	phosphorylation site [posttranslational modification]
1261557002309	intermolecular recognition site; other site
1261557002310	dimerization interface [polypeptide binding]; other site
1261557002311	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1261557002312	DNA binding site [nucleotide binding]
1261557002313	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1261557002314	dimer interface [polypeptide binding]; other site
1261557002315	His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388
1261557002316	phosphorylation site [posttranslational modification]
1261557002317	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1261557002318	ATP binding site [chemical binding]; other site
1261557002319	Mg2+ binding site [ion binding]; other site
1261557002320	G-X-G motif; other site
1261557002321	Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975
1261557002322	L-rhamnose-proton symport protein (RhaT); Region: RhaT; cl05728
1261557002323	amino acid transporter; Region: 2A0306; TIGR00909
1261557002324	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
1261557002325	methionyl-tRNA synthetase; Reviewed; Region: PRK12267
1261557002326	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
1261557002327	active site
1261557002328	HIGH motif; other site
1261557002329	KMSKS motif; other site
1261557002330	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
1261557002331	tRNA binding surface [nucleotide binding]; other site
1261557002332	anticodon binding site; other site
1261557002333	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
1261557002334	dimer interface [polypeptide binding]; other site
1261557002335	putative tRNA-binding site [nucleotide binding]; other site
1261557002336	Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973
1261557002337	Part of AAA domain; Region: AAA_19; pfam13245
1261557002338	Family description; Region: UvrD_C_2; pfam13538
1261557002339	Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099
1261557002340	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
1261557002341	active site
1261557002342	ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334
1261557002343	TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea.  RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027
1261557002344	putative active site [active]
1261557002345	putative metal binding site [ion binding]; other site
1261557002346	Domain of unknown function (DUF4093); Region: DUF4093; pfam13331
1261557002347	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
1261557002348	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1261557002349	S-adenosylmethionine binding site [chemical binding]; other site
1261557002350	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
1261557002351	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
1261557002352	Walker A/P-loop; other site
1261557002353	ATP binding site [chemical binding]; other site
1261557002354	Q-loop/lid; other site
1261557002355	ABC transporter signature motif; other site
1261557002356	Walker B; other site
1261557002357	D-loop; other site
1261557002358	H-loop/switch region; other site
1261557002359	TOBE domain; Region: TOBE_2; pfam08402
1261557002360	Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422
1261557002361	active site
1261557002362	dimer interfaces [polypeptide binding]; other site
1261557002363	catalytic residues [active]
1261557002364	hypothetical protein; Provisional; Region: PRK09609
1261557002365	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
1261557002366	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1261557002367	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
1261557002368	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
1261557002369	Walker A/P-loop; other site
1261557002370	ATP binding site [chemical binding]; other site
1261557002371	Q-loop/lid; other site
1261557002372	ABC transporter signature motif; other site
1261557002373	Walker B; other site
1261557002374	D-loop; other site
1261557002375	H-loop/switch region; other site
1261557002376	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1261557002377	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1261557002378	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1261557002379	Walker A/P-loop; other site
1261557002380	ATP binding site [chemical binding]; other site
1261557002381	Q-loop/lid; other site
1261557002382	ABC transporter signature motif; other site
1261557002383	Walker B; other site
1261557002384	D-loop; other site
1261557002385	H-loop/switch region; other site
1261557002386	Predicted membrane protein [Function unknown]; Region: COG4905
1261557002387	Protein of unknown function (DUF1113); Region: DUF1113; pfam06541
1261557002388	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883
1261557002389	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584
1261557002390	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1261557002391	Coenzyme A binding pocket [chemical binding]; other site
1261557002392	Tubby C 2; Region: Tub_2; cl02043
1261557002393	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1261557002394	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
1261557002395	active site
1261557002396	motif I; other site
1261557002397	motif II; other site
1261557002398	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
1261557002399	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
1261557002400	ligand binding site [chemical binding]; other site
1261557002401	active site
1261557002402	UGI interface [polypeptide binding]; other site
1261557002403	catalytic site [active]
1261557002404	phosphotransacetylase; Reviewed; Region: eutD; PRK09653
1261557002405	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
1261557002406	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1261557002407	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1261557002408	Coenzyme A binding pocket [chemical binding]; other site
1261557002409	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1261557002410	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1261557002411	DNA binding site [nucleotide binding]
1261557002412	domain linker motif; other site
1261557002413	Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294
1261557002414	putative dimerization interface [polypeptide binding]; other site
1261557002415	putative ligand binding site [chemical binding]; other site
1261557002416	galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
1261557002417	active site
1261557002418	catalytic residues [active]
1261557002419	beta-phosphoglucomutase; Region: bPGM; TIGR01990
1261557002420	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1261557002421	motif II; other site
1261557002422	maltose phosphorylase; Provisional; Region: PRK13807
1261557002423	Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636
1261557002424	Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632
1261557002425	Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633
1261557002426	PTS system, IIBC component; Region: PTS-II-BC-unk1; TIGR02003
1261557002427	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
1261557002428	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1261557002429	active site turn [active]
1261557002430	phosphorylation site [posttranslational modification]
1261557002431	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
1261557002432	HPr interaction site; other site
1261557002433	glycerol kinase (GK) interaction site [polypeptide binding]; other site
1261557002434	active site
1261557002435	phosphorylation site [posttranslational modification]
1261557002436	Streptococcus agalactiae RgfB, part of a putative two component signal transduction system, and related proteins; Region: RgfB-like; cd09079
1261557002437	putative catalytic site [active]
1261557002438	putative metal binding site [ion binding]; other site
1261557002439	putative phosphate binding site [ion binding]; other site
1261557002440	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
1261557002441	pyrroline-5-carboxylate reductase; Region: proC; TIGR00112
1261557002442	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1261557002443	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1261557002444	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537
1261557002445	homodimer interface [polypeptide binding]; other site
1261557002446	chemical substrate binding site [chemical binding]; other site
1261557002447	oligomer interface [polypeptide binding]; other site
1261557002448	metal binding site [ion binding]; metal-binding site
1261557002449	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1261557002450	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
1261557002451	active site
1261557002452	Protein of unknown function (DUF2974); Region: DUF2974; pfam11187
1261557002453	50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278
1261557002454	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
1261557002455	Protein of unknown function (DUF464); Region: DUF464; pfam04327
1261557002456	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
1261557002457	phosphate-starvation-inducible protein PsiE; Provisional; Region: PRK02833
1261557002458	phosphodiesterase YaeI; Provisional; Region: PRK11340
1261557002459	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
1261557002460	putative active site [active]
1261557002461	putative metal binding site [ion binding]; other site
1261557002462	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
1261557002463	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
1261557002464	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
1261557002465	active site
1261557002466	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cd11523
1261557002467	metal binding site [ion binding]; metal-binding site
1261557002468	Asp23 family; Region: Asp23; pfam03780
1261557002469	transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202
1261557002470	putative RNA binding site [nucleotide binding]; other site
1261557002471	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14179
1261557002472	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
1261557002473	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
1261557002474	homodimer interface [polypeptide binding]; other site
1261557002475	NADP binding site [chemical binding]; other site
1261557002476	substrate binding site [chemical binding]; other site
1261557002477	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
1261557002478	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
1261557002479	generic binding surface II; other site
1261557002480	generic binding surface I; other site
1261557002481	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
1261557002482	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
1261557002483	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
1261557002484	substrate binding pocket [chemical binding]; other site
1261557002485	chain length determination region; other site
1261557002486	substrate-Mg2+ binding site; other site
1261557002487	catalytic residues [active]
1261557002488	aspartate-rich region 1; other site
1261557002489	active site lid residues [active]
1261557002490	aspartate-rich region 2; other site
1261557002491	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
1261557002492	S4 RNA-binding domain; Region: S4; smart00363
1261557002493	RNA binding surface [nucleotide binding]; other site
1261557002494	FtsJ-like methyltransferase; Region: FtsJ; pfam01728
1261557002495	Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
1261557002496	active site
1261557002497	Arginine repressor [Transcription]; Region: ArgR; COG1438
1261557002498	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
1261557002499	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
1261557002500	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
1261557002501	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
1261557002502	Walker A/P-loop; other site
1261557002503	ATP binding site [chemical binding]; other site
1261557002504	Q-loop/lid; other site
1261557002505	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
1261557002506	ABC transporter signature motif; other site
1261557002507	Walker B; other site
1261557002508	D-loop; other site
1261557002509	H-loop/switch region; other site
1261557002510	Protein of unknown function (DUF4044); Region: DUF4044; pfam13253
1261557002511	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
1261557002512	uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827
1261557002513	Cl binding site [ion binding]; other site
1261557002514	oligomer interface [polypeptide binding]; other site
1261557002515	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001
1261557002516	MraZ protein; Region: MraZ; pfam02381
1261557002517	MraZ protein; Region: MraZ; pfam02381
1261557002518	MraW methylase family; Region: Methyltransf_5; pfam01795
1261557002519	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
1261557002520	Cell division protein FtsL; Region: FtsL; cl11433
1261557002521	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
1261557002522	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
1261557002523	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1261557002524	PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576
1261557002525	PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575
1261557002526	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
1261557002527	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
1261557002528	Mg++ binding site [ion binding]; other site
1261557002529	putative catalytic motif [active]
1261557002530	putative substrate binding site [chemical binding]; other site
1261557002531	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472
1261557002532	Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002
1261557002533	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1261557002534	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1261557002535	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
1261557002536	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
1261557002537	active site
1261557002538	homodimer interface [polypeptide binding]; other site
1261557002539	Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589
1261557002540	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
1261557002541	Cell division protein FtsQ; Region: FtsQ; pfam03799
1261557002542	Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849
1261557002543	Cell division protein FtsA; Region: FtsA; smart00842
1261557002544	Cell division protein FtsA; Region: FtsA; pfam14450
1261557002545	Domain of unknown function (DUF3484); Region: DUF3484; pfam11983
1261557002546	cell division protein FtsZ; Validated; Region: PRK09330
1261557002547	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
1261557002548	nucleotide binding site [chemical binding]; other site
1261557002549	SulA interaction site; other site
1261557002550	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
1261557002551	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1261557002552	catalytic residue [active]
1261557002553	Protein of unknown function (DUF552); Region: DUF552; pfam04472
1261557002554	YGGT family; Region: YGGT; pfam02325
1261557002555	Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302
1261557002556	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1261557002557	RNA binding surface [nucleotide binding]; other site
1261557002558	DivIVA protein; Region: DivIVA; pfam05103
1261557002559	DivIVA domain; Region: DivI1A_domain; TIGR03544
1261557002560	The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual proteins of this...; Region: Band_7; cl02525
1261557002561	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
1261557002562	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1261557002563	active site
1261557002564	HIGH motif; other site
1261557002565	nucleotide binding site [chemical binding]; other site
1261557002566	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
1261557002567	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
1261557002568	active site
1261557002569	KMSKS motif; other site
1261557002570	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
1261557002571	tRNA binding surface [nucleotide binding]; other site
1261557002572	anticodon binding site; other site
1261557002573	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
1261557002574	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
1261557002575	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
1261557002576	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
1261557002577	Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321
1261557002578	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
1261557002579	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
1261557002580	FeoA domain; Region: FeoA; pfam04023
1261557002581	putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347
1261557002582	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1261557002583	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1261557002584	ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192
1261557002585	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
1261557002586	ATP binding site [chemical binding]; other site
1261557002587	putative Mg++ binding site [ion binding]; other site
1261557002588	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1261557002589	nucleotide binding region [chemical binding]; other site
1261557002590	ATP-binding site [chemical binding]; other site
1261557002591	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1261557002592	putative Zn2+ binding site [ion binding]; other site
1261557002593	putative DNA binding site [nucleotide binding]; other site
1261557002594	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1261557002595	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
1261557002596	Walker A motif; other site
1261557002597	ATP binding site [chemical binding]; other site
1261557002598	Walker B motif; other site
1261557002599	arginine finger; other site
1261557002600	Transcriptional antiterminator [Transcription]; Region: COG3933
1261557002601	PRD domain; Region: PRD; pfam00874
1261557002602	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
1261557002603	active pocket/dimerization site; other site
1261557002604	active site
1261557002605	phosphorylation site [posttranslational modification]
1261557002606	PRD domain; Region: PRD; pfam00874
1261557002607	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
1261557002608	active site
1261557002609	P-loop; other site
1261557002610	phosphorylation site [posttranslational modification]
1261557002611	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
1261557002612	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
1261557002613	Domain of unknown function (DUF3284); Region: DUF3284; pfam11687
1261557002614	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
1261557002615	active site
1261557002616	P-loop; other site
1261557002617	phosphorylation site [posttranslational modification]
1261557002618	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
1261557002619	active site
1261557002620	methionine cluster; other site
1261557002621	phosphorylation site [posttranslational modification]
1261557002622	metal binding site [ion binding]; metal-binding site
1261557002623	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
1261557002624	Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378
1261557002625	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
1261557002626	beta-galactosidase; Region: BGL; TIGR03356
1261557002627	Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527
1261557002628	Sterol carrier protein domain; Region: SCP2_2; pfam13530
1261557002629	Uncharacterized conserved protein [Function unknown]; Region: COG1359
1261557002630	pyruvate, phosphate dikinase; Region: pyru_phos_dikin; TIGR01828
1261557002631	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
1261557002632	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
1261557002633	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
1261557002634	HTH domain; Region: HTH_11; pfam08279
1261557002635	FOG: CBS domain [General function prediction only]; Region: COG0517
1261557002636	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617
1261557002637	Kinase/pyrophosphorylase; Region: Kinase-PPPase; pfam03618
1261557002638	Predicted integral membrane protein [Function unknown]; Region: COG0392
1261557002639	Uncharacterized conserved protein [Function unknown]; Region: COG2898
1261557002640	Keratinocyte-associated protein 2; Region: Keratin_assoc; pfam09775
1261557002641	Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924
1261557002642	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1261557002643	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1261557002644	AAA domain; Region: AAA_17; cl17253
1261557002645	AAA domain; Region: AAA_18; pfam13238
1261557002646	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
1261557002647	putative catalytic site [active]
1261557002648	putative metal binding site [ion binding]; other site
1261557002649	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
1261557002650	putative catalytic site [active]
1261557002651	putative phosphate binding site [ion binding]; other site
1261557002652	putative phosphate binding site [ion binding]; other site
1261557002653	putative metal binding site [ion binding]; other site
1261557002654	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Provisional; Region: PRK07164
1261557002655	Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048
1261557002656	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
1261557002657	Integrase core domain; Region: rve; pfam00665
1261557002658	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1261557002659	Walker A/P-loop; other site
1261557002660	ATP binding site [chemical binding]; other site
1261557002661	Q-loop/lid; other site
1261557002662	Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178
1261557002663	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
1261557002664	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1261557002665	Walker A/P-loop; other site
1261557002666	ATP binding site [chemical binding]; other site
1261557002667	Q-loop/lid; other site
1261557002668	ABC transporter signature motif; other site
1261557002669	Walker B; other site
1261557002670	D-loop; other site
1261557002671	H-loop/switch region; other site
1261557002672	amidase; Provisional; Region: PRK06529
1261557002673	Amidase; Region: Amidase; cl11426
1261557002674	Phosphotransferase enzyme family; Region: APH; pfam01636
1261557002675	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
1261557002676	active site
1261557002677	ATP binding site [chemical binding]; other site
1261557002678	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
1261557002679	active site
1261557002680	multimer interface [polypeptide binding]; other site
1261557002681	aspartate 4-decarboxylase; Region: asp_4_decarbox; TIGR03801
1261557002682	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1261557002683	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1261557002684	homodimer interface [polypeptide binding]; other site
1261557002685	catalytic residue [active]
1261557002686	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1261557002687	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
1261557002688	active site
1261557002689	motif I; other site
1261557002690	motif II; other site
1261557002691	Protein of unknown function (DUF1361); Region: DUF1361; pfam07099
1261557002692	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
1261557002693	drug efflux system protein MdtG; Provisional; Region: PRK09874
1261557002694	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1261557002695	putative substrate translocation pore; other site
1261557002696	Protein of unknown function (DUF2929); Region: DUF2929; pfam11151
1261557002697	DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587
1261557002698	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
1261557002699	active site
1261557002700	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
1261557002701	generic binding surface II; other site
1261557002702	generic binding surface I; other site
1261557002703	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763
1261557002704	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
1261557002705	active site
1261557002706	ADP/pyrophosphate binding site [chemical binding]; other site
1261557002707	dimerization interface [polypeptide binding]; other site
1261557002708	allosteric effector site; other site
1261557002709	fructose-1,6-bisphosphate binding site; other site
1261557002710	pyruvate kinase; Provisional; Region: PRK06354
1261557002711	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
1261557002712	domain interfaces; other site
1261557002713	active site
1261557002714	Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848
1261557002715	Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399
1261557002716	50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286
1261557002717	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
1261557002718	6-phosphogluconate dehydrogenase; Validated; Region: PRK09287
1261557002719	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
1261557002720	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1261557002721	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1261557002722	active site
1261557002723	phosphorylation site [posttranslational modification]
1261557002724	intermolecular recognition site; other site
1261557002725	dimerization interface [polypeptide binding]; other site
1261557002726	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1261557002727	DNA binding site [nucleotide binding]
1261557002728	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1261557002729	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1261557002730	dimerization interface [polypeptide binding]; other site
1261557002731	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1261557002732	dimer interface [polypeptide binding]; other site
1261557002733	phosphorylation site [posttranslational modification]
1261557002734	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1261557002735	ATP binding site [chemical binding]; other site
1261557002736	Mg2+ binding site [ion binding]; other site
1261557002737	G-X-G motif; other site
1261557002738	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
1261557002739	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
1261557002740	Walker A/P-loop; other site
1261557002741	ATP binding site [chemical binding]; other site
1261557002742	Q-loop/lid; other site
1261557002743	ABC transporter signature motif; other site
1261557002744	Walker B; other site
1261557002745	D-loop; other site
1261557002746	H-loop/switch region; other site
1261557002747	ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism]; Region: COG4986
1261557002748	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1261557002749	dimer interface [polypeptide binding]; other site
1261557002750	conserved gate region; other site
1261557002751	putative PBP binding loops; other site
1261557002752	ABC-ATPase subunit interface; other site
1261557002753	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1261557002754	dimer interface [polypeptide binding]; other site
1261557002755	conserved gate region; other site
1261557002756	ABC-ATPase subunit interface; other site
1261557002757	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
1261557002758	AAA domain; Region: AAA_18; pfam13238
1261557002759	active site
1261557002760	manganese transport protein MntH; Reviewed; Region: PRK00701
1261557002761	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
1261557002762	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1261557002763	Ligand Binding Site [chemical binding]; other site
1261557002764	Purine catabolism regulatory protein-like family; Region: PucR; pfam07905
1261557002765	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
1261557002766	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
1261557002767	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
1261557002768	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
1261557002769	peptide binding site [polypeptide binding]; other site
1261557002770	putative deaminase; Validated; Region: PRK06846
1261557002771	Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293
1261557002772	active site
1261557002773	putative deaminase; Validated; Region: PRK06846
1261557002774	Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293
1261557002775	active site
1261557002776	GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956
1261557002777	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
1261557002778	dimer interface [polypeptide binding]; other site
1261557002779	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1261557002780	maltose O-acetyltransferase; Provisional; Region: PRK10092
1261557002781	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
1261557002782	active site
1261557002783	substrate binding site [chemical binding]; other site
1261557002784	trimer interface [polypeptide binding]; other site
1261557002785	CoA binding site [chemical binding]; other site
1261557002786	galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
1261557002787	active site
1261557002788	catalytic residues [active]
1261557002789	galactokinase; Provisional; Region: PRK05322
1261557002790	Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509
1261557002791	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
1261557002792	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
1261557002793	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
1261557002794	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
1261557002795	NAD binding site [chemical binding]; other site
1261557002796	homodimer interface [polypeptide binding]; other site
1261557002797	active site
1261557002798	substrate binding site [chemical binding]; other site
1261557002799	galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270
1261557002800	Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087
1261557002801	Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744
1261557002802	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1261557002803	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1261557002804	DNA binding site [nucleotide binding]
1261557002805	Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544
1261557002806	putative ligand binding site [chemical binding]; other site
1261557002807	putative dimerization interface [polypeptide binding]; other site
1261557002808	hypothetical protein; Provisional; Region: PRK06762
1261557002809	AAA domain; Region: AAA_33; pfam13671
1261557002810	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1261557002811	Coenzyme A binding pocket [chemical binding]; other site
1261557002812	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1261557002813	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
1261557002814	active site
1261557002815	NTP binding site [chemical binding]; other site
1261557002816	metal binding triad [ion binding]; metal-binding site
1261557002817	Domain of unknown function (DUF4111); Region: DUF4111; pfam13427
1261557002818	Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420
1261557002819	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1261557002820	Coenzyme A binding pocket [chemical binding]; other site
1261557002821	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1261557002822	putative substrate translocation pore; other site
1261557002823	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1261557002824	DNA polymerase IV; Reviewed; Region: PRK03103
1261557002825	umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700
1261557002826	active site
1261557002827	DNA binding site [nucleotide binding]
1261557002828	Protein of unknown function (DUF3016); Region: DUF3016; pfam11454
1261557002829	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1261557002830	Ligand Binding Site [chemical binding]; other site
1261557002831	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1261557002832	Coenzyme A binding pocket [chemical binding]; other site
1261557002833	Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761
1261557002834	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
1261557002835	Protein of unknown function (DUF805); Region: DUF805; pfam05656
1261557002836	Mga helix-turn-helix domain; Region: Mga; pfam05043
1261557002837	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
1261557002838	metal ion-dependent adhesion site (MIDAS); other site
1261557002839	Cna protein B-type domain; Region: Cna_B; pfam05738
1261557002840	Cna protein B-type domain; Region: Cna_B; pfam05738
1261557002841	fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226
1261557002842	Cna protein B-type domain; Region: Cna_B; pfam05738
1261557002843	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
1261557002844	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
1261557002845	Helix-turn-helix domain; Region: HTH_38; pfam13936
1261557002846	Integrase core domain; Region: rve; pfam00665
1261557002847	fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226
1261557002848	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
1261557002849	Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827
1261557002850	active site
1261557002851	catalytic site [active]
1261557002852	Domain of unknown function (DUF378); Region: DUF378; pfam04070
1261557002853	Bacterial protein of unknown function (DUF898); Region: DUF898; cl01738
1261557002854	Collagen binding domain; Region: Collagen_bind; pfam05737
1261557002855	Gram positive anchor; Region: Gram_pos_anchor; pfam00746
1261557002856	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1261557002857	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1261557002858	Walker A/P-loop; other site
1261557002859	ATP binding site [chemical binding]; other site
1261557002860	Q-loop/lid; other site
1261557002861	ABC transporter signature motif; other site
1261557002862	Walker B; other site
1261557002863	D-loop; other site
1261557002864	H-loop/switch region; other site
1261557002865	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1261557002866	S-adenosylmethionine binding site [chemical binding]; other site
1261557002867	Protein of unknown function (DUF1093); Region: DUF1093; pfam06486
1261557002868	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
1261557002869	CoB--CoM heterodisulfide reductase, subunit B; Region: CoB_CoM_SS_B; TIGR03288
1261557002870	Cysteine-rich domain; Region: CCG; pfam02754
1261557002871	Cysteine-rich domain; Region: CCG; pfam02754
1261557002872	Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139
1261557002873	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
1261557002874	Domain of unknown function (DUF3390); Region: DUF3390; pfam11870
1261557002875	Uncharacterized conserved protein [Function unknown]; Region: COG1556
1261557002876	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
1261557002877	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
1261557002878	Catalytic site [active]
1261557002879	helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773
1261557002880	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
1261557002881	helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785
1261557002882	Part of AAA domain; Region: AAA_19; pfam13245
1261557002883	Family description; Region: UvrD_C_2; pfam13538
1261557002884	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
1261557002885	Predicted transcriptional regulators [Transcription]; Region: COG1733
1261557002886	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
1261557002887	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
1261557002888	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
1261557002889	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
1261557002890	dimer interface [polypeptide binding]; other site
1261557002891	motif 1; other site
1261557002892	active site
1261557002893	motif 2; other site
1261557002894	motif 3; other site
1261557002895	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
1261557002896	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
1261557002897	putative tRNA-binding site [nucleotide binding]; other site
1261557002898	B3/4 domain; Region: B3_4; pfam03483
1261557002899	tRNA synthetase B5 domain; Region: B5; smart00874
1261557002900	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
1261557002901	dimer interface [polypeptide binding]; other site
1261557002902	motif 1; other site
1261557002903	motif 3; other site
1261557002904	motif 2; other site
1261557002905	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
1261557002906	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1261557002907	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1261557002908	dimer interface [polypeptide binding]; other site
1261557002909	conserved gate region; other site
1261557002910	putative PBP binding loops; other site
1261557002911	ABC-ATPase subunit interface; other site
1261557002912	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1261557002913	dimer interface [polypeptide binding]; other site
1261557002914	conserved gate region; other site
1261557002915	putative PBP binding loops; other site
1261557002916	ABC-ATPase subunit interface; other site
1261557002917	bifunctional adhesin/ABC transporter aspartate/glutamate-binding protein; Reviewed; Region: PRK11917
1261557002918	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1261557002919	substrate binding pocket [chemical binding]; other site
1261557002920	membrane-bound complex binding site; other site
1261557002921	hinge residues; other site
1261557002922	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1261557002923	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1261557002924	Walker A/P-loop; other site
1261557002925	ATP binding site [chemical binding]; other site
1261557002926	Q-loop/lid; other site
1261557002927	ABC transporter signature motif; other site
1261557002928	Walker B; other site
1261557002929	D-loop; other site
1261557002930	H-loop/switch region; other site
1261557002931	glutamate racemase; Provisional; Region: PRK00865
1261557002932	ribonuclease PH; Reviewed; Region: rph; PRK00173
1261557002933	Ribonuclease PH; Region: RNase_PH_bact; cd11362
1261557002934	hexamer interface [polypeptide binding]; other site
1261557002935	active site
1261557002936	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
1261557002937	active site
1261557002938	dimerization interface [polypeptide binding]; other site
1261557002939	Predicted phosphoesterases, related to the Icc protein [General function prediction only]; Region: COG2129
1261557002940	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
1261557002941	active site
1261557002942	metal binding site [ion binding]; metal-binding site
1261557002943	homotetramer interface [polypeptide binding]; other site
1261557002944	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
1261557002945	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
1261557002946	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
1261557002947	putative L-ascorbate 6-phosphate lactonase; Provisional; Region: PRK11709
1261557002948	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
1261557002949	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1261557002950	active site
1261557002951	phosphorylation site [posttranslational modification]
1261557002952	PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: PRK12997
1261557002953	PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563
1261557002954	active site
1261557002955	P-loop; other site
1261557002956	phosphorylation site [posttranslational modification]
1261557002957	3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726
1261557002958	active site
1261557002959	dimer interface [polypeptide binding]; other site
1261557002960	magnesium binding site [ion binding]; other site
1261557002961	putative L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13210
1261557002962	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
1261557002963	AP (apurinic/apyrimidinic) site pocket; other site
1261557002964	DNA interaction; other site
1261557002965	Metal-binding active site; metal-binding site
1261557002966	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214
1261557002967	L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193
1261557002968	intersubunit interface [polypeptide binding]; other site
1261557002969	active site
1261557002970	Zn2+ binding site [ion binding]; other site
1261557002971	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643
1261557002972	Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503
1261557002973	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532
1261557002974	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350
1261557002975	active site
1261557002976	trimer interface [polypeptide binding]; other site
1261557002977	substrate binding site [chemical binding]; other site
1261557002978	CoA binding site [chemical binding]; other site
1261557002979	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
1261557002980	M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670
1261557002981	metal binding site [ion binding]; metal-binding site
1261557002982	putative dimer interface [polypeptide binding]; other site
1261557002983	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
1261557002984	Mechanosensitive ion channel; Region: MS_channel; pfam00924
1261557002985	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1261557002986	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1261557002987	active site
1261557002988	catalytic tetrad [active]
1261557002989	Peptidase C26; Region: Peptidase_C26; pfam07722
1261557002990	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
1261557002991	catalytic triad [active]
1261557002992	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1261557002993	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
1261557002994	dimer interface [polypeptide binding]; other site
1261557002995	active site
1261557002996	metal binding site [ion binding]; metal-binding site
1261557002997	glutathione binding site [chemical binding]; other site
1261557002998	Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684
1261557002999	nudix motif; other site
1261557003000	sugar phosphate phosphatase; Provisional; Region: PRK10513
1261557003001	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1261557003002	active site
1261557003003	motif I; other site
1261557003004	motif II; other site
1261557003005	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1261557003006	HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078
1261557003007	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1261557003008	Zn2+ binding site [ion binding]; other site
1261557003009	Mg2+ binding site [ion binding]; other site
1261557003010	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
1261557003011	Domain of unknown function (DUF1934); Region: DUF1934; pfam09148
1261557003012	DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066
1261557003013	CTP synthetase; Validated; Region: pyrG; PRK05380
1261557003014	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
1261557003015	Catalytic site [active]
1261557003016	active site
1261557003017	UTP binding site [chemical binding]; other site
1261557003018	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
1261557003019	active site
1261557003020	putative oxyanion hole; other site
1261557003021	catalytic triad [active]
1261557003022	Transglycosylase; Region: Transgly; pfam00912
1261557003023	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
1261557003024	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
1261557003025	Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234
1261557003026	hypothetical protein; Provisional; Region: PRK13660
1261557003027	cell division protein GpsB; Provisional; Region: PRK14127
1261557003028	DivIVA domain; Region: DivI1A_domain; TIGR03544
1261557003029	Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116
1261557003030	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
1261557003031	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
1261557003032	Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317
1261557003033	Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460
1261557003034	active site
1261557003035	Zn binding site [ion binding]; other site
1261557003036	Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935
1261557003037	Helix-turn-helix domain; Region: HTH_36; pfam13730
1261557003038	Replication initiation and membrane attachment; Region: DnaB_2; pfam07261
1261557003039	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
1261557003040	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
1261557003041	minor groove reading motif; other site
1261557003042	helix-hairpin-helix signature motif; other site
1261557003043	substrate binding pocket [chemical binding]; other site
1261557003044	active site
1261557003045	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
1261557003046	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1261557003047	DNA-binding site [nucleotide binding]; DNA binding site
1261557003048	UTRA domain; Region: UTRA; pfam07702
1261557003049	M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888
1261557003050	dipeptidase, putative; Region: dipeptidaselike; TIGR01887
1261557003051	active site
1261557003052	metal binding site [ion binding]; metal-binding site
1261557003053	Glycosylasparaginase catalyzes the hydrolysis of the glycosylamide bond of asparagine-linked glycoproteins. This enzyme is an amidase located inside lysosomes. Mutation of this gene in humans causes a genetic disorder known as aspartylglycosaminuria (AGU)...; Region: Glycosylasparaginase; cd04513
1261557003054	active site
1261557003055	dimer interface [polypeptide binding]; other site
1261557003056	catalytic nucleophile [active]
1261557003057	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
1261557003058	active site
1261557003059	P-loop; other site
1261557003060	phosphorylation site [posttranslational modification]
1261557003061	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
1261557003062	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
1261557003063	glycine reductase, selenoprotein B; Region: gly_red_sel_B; TIGR01917
1261557003064	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
1261557003065	DEAD/DEAH box helicase; Region: DEAD; pfam00270
1261557003066	ATP binding site [chemical binding]; other site
1261557003067	DEAD_2; Region: DEAD_2; pfam06733
1261557003068	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
1261557003069	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
1261557003070	active site
1261557003071	homotetramer interface [polypeptide binding]; other site
1261557003072	homodimer interface [polypeptide binding]; other site
1261557003073	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1261557003074	Zn2+ binding site [ion binding]; other site
1261557003075	Mg2+ binding site [ion binding]; other site
1261557003076	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666
1261557003077	Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740
1261557003078	Uncharacterized conserved protein [Function unknown]; Region: COG1284
1261557003079	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
1261557003080	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
1261557003081	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
1261557003082	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
1261557003083	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
1261557003084	intersubunit interface [polypeptide binding]; other site
1261557003085	active site
1261557003086	zinc binding site [ion binding]; other site
1261557003087	Na+ binding site [ion binding]; other site
1261557003088	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
1261557003089	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
1261557003090	hinge; other site
1261557003091	active site
1261557003092	transcription termination factor Rho; Provisional; Region: rho; PRK09376
1261557003093	Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498
1261557003094	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
1261557003095	RNA binding site [nucleotide binding]; other site
1261557003096	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
1261557003097	multimer interface [polypeptide binding]; other site
1261557003098	Walker A motif; other site
1261557003099	ATP binding site [chemical binding]; other site
1261557003100	Walker B motif; other site
1261557003101	50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678
1261557003102	Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030
1261557003103	Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797
1261557003104	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
1261557003105	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
1261557003106	nucleotide binding site [chemical binding]; other site
1261557003107	CsbD-like; Region: CsbD; cl17424
1261557003108	This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146
1261557003109	dimer interface [polypeptide binding]; other site
1261557003110	FMN binding site [chemical binding]; other site
1261557003111	NADPH bind site [chemical binding]; other site
1261557003112	S-ribosylhomocysteinase; Provisional; Region: PRK02260
1261557003113	Transposase, Mutator family; Region: Transposase_mut; pfam00872
1261557003114	Transposase, Mutator family; Region: Transposase_mut; pfam00872
1261557003115	MULE transposase domain; Region: MULE; pfam10551
1261557003116	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
1261557003117	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
1261557003118	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
1261557003119	dihydrodipicolinate synthase; Region: dapA; TIGR00674
1261557003120	dimer interface [polypeptide binding]; other site
1261557003121	active site
1261557003122	catalytic residue [active]
1261557003123	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
1261557003124	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1261557003125	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
1261557003126	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
1261557003127	Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845
1261557003128	active site
1261557003129	metal binding site [ion binding]; metal-binding site
1261557003130	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
1261557003131	Protein of unknown function (DUF1027); Region: DUF1027; pfam06265
1261557003132	HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2
1261557003133	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1261557003134	active site
1261557003135	motif I; other site
1261557003136	motif II; other site
1261557003137	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1261557003138	integral membrane protein TIGR01906; Region: integ_TIGR01906
1261557003139	Domain of unknown function (DUF1836); Region: DUF1836; pfam08876
1261557003140	EDD domain protein, DegV family; Region: DegV; TIGR00762
1261557003141	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
1261557003142	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
1261557003143	amphipathic channel; other site
1261557003144	Asn-Pro-Ala signature motifs; other site
1261557003145	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1261557003146	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1261557003147	active site
1261557003148	phosphorylation site [posttranslational modification]
1261557003149	intermolecular recognition site; other site
1261557003150	dimerization interface [polypeptide binding]; other site
1261557003151	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1261557003152	DNA binding site [nucleotide binding]
1261557003153	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002
1261557003154	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1261557003155	dimerization interface [polypeptide binding]; other site
1261557003156	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1261557003157	putative active site [active]
1261557003158	heme pocket [chemical binding]; other site
1261557003159	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1261557003160	dimer interface [polypeptide binding]; other site
1261557003161	phosphorylation site [posttranslational modification]
1261557003162	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1261557003163	ATP binding site [chemical binding]; other site
1261557003164	Mg2+ binding site [ion binding]; other site
1261557003165	G-X-G motif; other site
1261557003166	YycH protein; Region: YycH; pfam07435
1261557003167	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863
1261557003168	YycH protein; Region: YycI; pfam09648
1261557003169	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
1261557003170	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
1261557003171	Predicted permeases [General function prediction only]; Region: COG0701
1261557003172	Domain of unknown function (DUF1980); Region: DUF1980; cl01492
1261557003173	Protein of unknown function (DUF3815); Region: DUF3815; pfam12821
1261557003174	Uncharacterized conserved protein [Function unknown]; Region: COG2966
1261557003175	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
1261557003176	hypothetical protein; Provisional; Region: PRK05473
1261557003177	Holliday junction resolvase-like protein; Reviewed; Region: PRK00109
1261557003178	hypothetical protein; Provisional; Region: PRK13678
1261557003179	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1261557003180	non-specific DNA binding site [nucleotide binding]; other site
1261557003181	salt bridge; other site
1261557003182	sequence-specific DNA binding site [nucleotide binding]; other site
1261557003183	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
1261557003184	binding surface
1261557003185	TPR motif; other site
1261557003186	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1261557003187	Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281
1261557003188	Malic enzyme, N-terminal domain; Region: malic; pfam00390
1261557003189	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
1261557003190	putative NAD(P) binding site [chemical binding]; other site
1261557003191	2-hydroxycarboxylate transporter family; Region: 2HCT; pfam03390
1261557003192	PAS domain S-box; Region: sensory_box; TIGR00229
1261557003193	Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565
1261557003194	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1261557003195	active site
1261557003196	phosphorylation site [posttranslational modification]
1261557003197	intermolecular recognition site; other site
1261557003198	dimerization interface [polypeptide binding]; other site
1261557003199	coenzyme A disulfide reductase; Reviewed; Region: PRK09564
1261557003200	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1261557003201	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1261557003202	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1261557003203	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581
1261557003204	acetolactate synthase; Reviewed; Region: PRK08617
1261557003205	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
1261557003206	PYR/PP interface [polypeptide binding]; other site
1261557003207	dimer interface [polypeptide binding]; other site
1261557003208	TPP binding site [chemical binding]; other site
1261557003209	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1261557003210	Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010
1261557003211	TPP-binding site [chemical binding]; other site
1261557003212	dimer interface [polypeptide binding]; other site
1261557003213	Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306
1261557003214	PQQ-like domain; Region: PQQ_2; pfam13360
1261557003215	WxL domain surface cell wall-binding; Region: WxL; pfam13731
1261557003216	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
1261557003217	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1261557003218	dimer interface [polypeptide binding]; other site
1261557003219	conserved gate region; other site
1261557003220	putative PBP binding loops; other site
1261557003221	ABC-ATPase subunit interface; other site
1261557003222	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
1261557003223	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1261557003224	dimer interface [polypeptide binding]; other site
1261557003225	conserved gate region; other site
1261557003226	putative PBP binding loops; other site
1261557003227	ABC-ATPase subunit interface; other site
1261557003228	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
1261557003229	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1261557003230	Walker A/P-loop; other site
1261557003231	ATP binding site [chemical binding]; other site
1261557003232	Q-loop/lid; other site
1261557003233	ABC transporter signature motif; other site
1261557003234	Walker B; other site
1261557003235	D-loop; other site
1261557003236	H-loop/switch region; other site
1261557003237	TOBE domain; Region: TOBE_2; pfam08402
1261557003238	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
1261557003239	Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343
1261557003240	Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001
1261557003241	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1261557003242	Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295
1261557003243	active site
1261557003244	Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382
1261557003245	TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298
1261557003246	N-ethylammeline chlorohydrolase; Provisional; Region: PRK09045
1261557003247	active site
1261557003248	putative substrate binding pocket [chemical binding]; other site
1261557003249	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1261557003250	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1261557003251	non-specific DNA binding site [nucleotide binding]; other site
1261557003252	salt bridge; other site
1261557003253	sequence-specific DNA binding site [nucleotide binding]; other site
1261557003254	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
1261557003255	ApbE family; Region: ApbE; pfam02424
1261557003256	Predicted flavoprotein [General function prediction only]; Region: COG0431
1261557003257	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1261557003258	Predicted flavoprotein [General function prediction only]; Region: COG0431
1261557003259	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1261557003260	PAS domain; Region: PAS_10; pfam13596
1261557003261	Mga helix-turn-helix domain; Region: Mga; pfam05043
1261557003262	DNA-binding domain found in transcription regulators in plants such as APETALA2 and EREBP (ethylene responsive element binding protein). In EREBPs the domain specifically binds to the 11bp GCC box of the ethylene response element (ERE), a promotor...; Region: AP2; cl00033
1261557003263	DNA binding site [nucleotide binding]
1261557003264	phosphodiesterase YaeI; Provisional; Region: PRK11340
1261557003265	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
1261557003266	putative active site [active]
1261557003267	putative metal binding site [ion binding]; other site
1261557003268	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
1261557003269	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1261557003270	dimer interface [polypeptide binding]; other site
1261557003271	conserved gate region; other site
1261557003272	ABC-ATPase subunit interface; other site
1261557003273	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1261557003274	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1261557003275	dimer interface [polypeptide binding]; other site
1261557003276	conserved gate region; other site
1261557003277	ABC-ATPase subunit interface; other site
1261557003278	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1261557003279	Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448
1261557003280	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1261557003281	Exonuclease-Endonuclease-Phosphatase domain; uncharacterized family 1; Region: EEP-1; cd09083
1261557003282	putative catalytic site [active]
1261557003283	putative metal binding site [ion binding]; other site
1261557003284	putative phosphate binding site [ion binding]; other site
1261557003285	beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098
1261557003286	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
1261557003287	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
1261557003288	Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459
1261557003289	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1261557003290	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1261557003291	DNA binding site [nucleotide binding]
1261557003292	domain linker motif; other site
1261557003293	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
1261557003294	dimerization interface [polypeptide binding]; other site
1261557003295	ligand binding site [chemical binding]; other site
1261557003296	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
1261557003297	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1261557003298	DNA-binding site [nucleotide binding]; DNA binding site
1261557003299	UTRA domain; Region: UTRA; pfam07702
1261557003300	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
1261557003301	beta-galactosidase; Region: BGL; TIGR03356
1261557003302	putative oxidoreductase; Provisional; Region: PRK10206
1261557003303	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1261557003304	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1261557003305	Protein of unknown function (DUF441); Region: DUF441; pfam04284
1261557003306	Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833
1261557003307	Domain of unknown function (DUF814); Region: DUF814; pfam05670
1261557003308	Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325
1261557003309	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
1261557003310	zinc binding site [ion binding]; other site
1261557003311	putative ligand binding site [chemical binding]; other site
1261557003312	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1261557003313	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574
1261557003314	TM-ABC transporter signature motif; other site
1261557003315	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101
1261557003316	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1261557003317	Walker A/P-loop; other site
1261557003318	ATP binding site [chemical binding]; other site
1261557003319	Q-loop/lid; other site
1261557003320	ABC transporter signature motif; other site
1261557003321	Walker B; other site
1261557003322	D-loop; other site
1261557003323	H-loop/switch region; other site
1261557003324	Protein of unknown function (DUF3815); Region: DUF3815; pfam12821
1261557003325	Uncharacterized conserved protein [Function unknown]; Region: COG2966
1261557003326	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
1261557003327	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
1261557003328	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1261557003329	active site
1261557003330	motif I; other site
1261557003331	motif II; other site
1261557003332	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
1261557003333	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1261557003334	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1261557003335	active site
1261557003336	phosphorylation site [posttranslational modification]
1261557003337	intermolecular recognition site; other site
1261557003338	dimerization interface [polypeptide binding]; other site
1261557003339	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1261557003340	DNA binding site [nucleotide binding]
1261557003341	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1261557003342	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1261557003343	dimerization interface [polypeptide binding]; other site
1261557003344	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1261557003345	dimer interface [polypeptide binding]; other site
1261557003346	phosphorylation site [posttranslational modification]
1261557003347	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1261557003348	ATP binding site [chemical binding]; other site
1261557003349	G-X-G motif; other site
1261557003350	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1261557003351	Q-loop/lid; other site
1261557003352	ABC transporter signature motif; other site
1261557003353	Walker B; other site
1261557003354	D-loop; other site
1261557003355	H-loop/switch region; other site
1261557003356	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368
1261557003357	Sulfatase; Region: Sulfatase; pfam00884
1261557003358	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
1261557003359	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
1261557003360	putative RNA binding site [nucleotide binding]; other site
1261557003361	ribonuclease HIII; Provisional; Region: PRK00996
1261557003362	Domain of unknown function (DUF3378); Region: DUF3378; pfam11858
1261557003363	bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590
1261557003364	RNA/DNA hybrid binding site [nucleotide binding]; other site
1261557003365	active site
1261557003366	ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494
1261557003367	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1261557003368	Collagen binding domain; Region: Collagen_bind; pfam05737
1261557003369	Cna protein B-type domain; Region: Cna_B; pfam05738
1261557003370	streptococcal pilin isopeptide linkage domain; Region: strep_pil_rpt; TIGR03786
1261557003371	ribosome maturation protein RimP; Reviewed; Region: PRK00092
1261557003372	Sm and related proteins; Region: Sm_like; cl00259
1261557003373	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
1261557003374	putative oligomer interface [polypeptide binding]; other site
1261557003375	putative RNA binding site [nucleotide binding]; other site
1261557003376	transcription elongation factor NusA; Provisional; Region: nusA; PRK12327
1261557003377	NusA N-terminal domain; Region: NusA_N; pfam08529
1261557003378	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
1261557003379	RNA binding site [nucleotide binding]; other site
1261557003380	homodimer interface [polypeptide binding]; other site
1261557003381	NusA-like KH domain; Region: KH_5; pfam13184
1261557003382	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
1261557003383	G-X-X-G motif; other site
1261557003384	Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279
1261557003385	putative RNA binding cleft [nucleotide binding]; other site
1261557003386	Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600
1261557003387	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
1261557003388	translation initiation factor IF-2; Region: IF-2; TIGR00487
1261557003389	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
1261557003390	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
1261557003391	G1 box; other site
1261557003392	putative GEF interaction site [polypeptide binding]; other site
1261557003393	GTP/Mg2+ binding site [chemical binding]; other site
1261557003394	Switch I region; other site
1261557003395	G2 box; other site
1261557003396	G3 box; other site
1261557003397	Switch II region; other site
1261557003398	G4 box; other site
1261557003399	G5 box; other site
1261557003400	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
1261557003401	Translation-initiation factor 2; Region: IF-2; pfam11987
1261557003402	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
1261557003403	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
1261557003404	Domain of unknown function (DUF955); Region: DUF955; pfam06114
1261557003405	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1261557003406	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1261557003407	non-specific DNA binding site [nucleotide binding]; other site
1261557003408	salt bridge; other site
1261557003409	sequence-specific DNA binding site [nucleotide binding]; other site
1261557003410	DnaD and phage-associated domain; Region: DnaD_dom; TIGR01446
1261557003411	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
1261557003412	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1261557003413	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
1261557003414	Walker A motif; other site
1261557003415	Walker A motif; other site
1261557003416	ATP binding site [chemical binding]; other site
1261557003417	ATP binding site [chemical binding]; other site
1261557003418	Walker B motif; other site
1261557003419	phage transcriptional activator, RinA family; Region: phage_rinA; TIGR01636
1261557003420	Phage major tail protein 2; Region: Phage_tail_2; cl11463
1261557003421	Phage protein; Region: DUF3647; pfam12363
1261557003422	Phage-related protein [Function unknown]; Region: COG5412
1261557003423	Phage tail protein; Region: Sipho_tail; pfam05709
1261557003424	Prophage endopeptidase tail; Region: Prophage_tail; cl12123
1261557003425	Holin family; Region: Phage_holin_4; pfam05105
1261557003426	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
1261557003427	amidase catalytic site [active]
1261557003428	Zn binding residues [ion binding]; other site
1261557003429	substrate binding site [chemical binding]; other site
1261557003430	Bacterial SH3 domain; Region: SH3_5; pfam08460
1261557003431	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01550
1261557003432	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
1261557003433	RNA binding site [nucleotide binding]; other site
1261557003434	active site
1261557003435	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
1261557003436	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
1261557003437	active site
1261557003438	Riboflavin kinase; Region: Flavokinase; smart00904
1261557003439	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1261557003440	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1261557003441	Coenzyme A binding pocket [chemical binding]; other site
1261557003442	Predicted transcriptional regulators [Transcription]; Region: COG1695
1261557003443	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
1261557003444	Protein of unknown function (DUF1048); Region: DUF1048; pfam06304
1261557003445	Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; pfam09860
1261557003446	Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772
1261557003447	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
1261557003448	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1261557003449	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1261557003450	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1261557003451	dimerization interface [polypeptide binding]; other site
1261557003452	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1261557003453	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1261557003454	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1261557003455	dimerization interface [polypeptide binding]; other site
1261557003456	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
1261557003457	magnesium-transporting ATPase; Provisional; Region: PRK15122
1261557003458	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1261557003459	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
1261557003460	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1261557003461	motif II; other site
1261557003462	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
1261557003463	coproporphyrinogen III oxidase; Provisional; Region: PRK08599
1261557003464	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1261557003465	FeS/SAM binding site; other site
1261557003466	HemN C-terminal domain; Region: HemN_C; pfam06969
1261557003467	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
1261557003468	Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444
1261557003469	GrpE; Region: GrpE; pfam01025
1261557003470	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
1261557003471	dimer interface [polypeptide binding]; other site
1261557003472	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
1261557003473	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
1261557003474	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
1261557003475	nucleotide binding site [chemical binding]; other site
1261557003476	NEF interaction site [polypeptide binding]; other site
1261557003477	SBD interface [polypeptide binding]; other site
1261557003478	chaperone protein DnaJ; Provisional; Region: PRK14276
1261557003479	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
1261557003480	HSP70 interaction site [polypeptide binding]; other site
1261557003481	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
1261557003482	substrate binding site [polypeptide binding]; other site
1261557003483	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
1261557003484	Zn binding sites [ion binding]; other site
1261557003485	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
1261557003486	substrate binding site [polypeptide binding]; other site
1261557003487	dimer interface [polypeptide binding]; other site
1261557003488	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1261557003489	phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144
1261557003490	active site
1261557003491	metal binding site [ion binding]; metal-binding site
1261557003492	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
1261557003493	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
1261557003494	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
1261557003495	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
1261557003496	RNA binding site [nucleotide binding]; other site
1261557003497	hypothetical protein; Provisional; Region: PRK04351
1261557003498	SprT homologues; Region: SprT; cl01182
1261557003499	aminotransferase AlaT; Validated; Region: PRK09265
1261557003500	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1261557003501	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1261557003502	homodimer interface [polypeptide binding]; other site
1261557003503	catalytic residue [active]
1261557003504	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1261557003505	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1261557003506	non-specific DNA binding site [nucleotide binding]; other site
1261557003507	salt bridge; other site
1261557003508	sequence-specific DNA binding site [nucleotide binding]; other site
1261557003509	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
1261557003510	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
1261557003511	active site
1261557003512	dimer interface [polypeptide binding]; other site
1261557003513	nitrogenase reductase; Reviewed; Region: nifH; PRK13235
1261557003514	DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; pfam13930
1261557003515	DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892
1261557003516	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1261557003517	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1261557003518	Walker A/P-loop; other site
1261557003519	ATP binding site [chemical binding]; other site
1261557003520	Q-loop/lid; other site
1261557003521	ABC transporter signature motif; other site
1261557003522	Walker B; other site
1261557003523	D-loop; other site
1261557003524	H-loop/switch region; other site
1261557003525	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1261557003526	FtsX-like permease family; Region: FtsX; pfam02687
1261557003527	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
1261557003528	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1261557003529	FtsX-like permease family; Region: FtsX; pfam02687
1261557003530	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268
1261557003531	Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  These two proteins are lipid raft-associated.  Individual proteins of...; Region: Band_7_flotillin; cd03399
1261557003532	Protein of unknown function (DUF2969); Region: DUF2969; pfam11184
1261557003533	probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366
1261557003534	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1261557003535	Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278
1261557003536	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
1261557003537	Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924
1261557003538	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
1261557003539	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3580
1261557003540	2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050
1261557003541	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581
1261557003542	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
1261557003543	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1261557003544	DNA-binding site [nucleotide binding]; DNA binding site
1261557003545	UTRA domain; Region: UTRA; pfam07702
1261557003546	Transposase, Mutator family; Region: Transposase_mut; pfam00872
1261557003547	MULE transposase domain; Region: MULE; pfam10551
1261557003548	ThiF family; Region: ThiF; pfam00899
1261557003549	Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 [Coenzyme metabolism]; Region: ThiF; COG0476
1261557003550	ATP binding site [chemical binding]; other site
1261557003551	substrate interface [chemical binding]; other site
1261557003552	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1261557003553	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1261557003554	Walker A/P-loop; other site
1261557003555	ATP binding site [chemical binding]; other site
1261557003556	Q-loop/lid; other site
1261557003557	ABC transporter signature motif; other site
1261557003558	Walker B; other site
1261557003559	D-loop; other site
1261557003560	H-loop/switch region; other site
1261557003561	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1261557003562	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
1261557003563	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
1261557003564	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
1261557003565	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1261557003566	Walker A/P-loop; other site
1261557003567	ATP binding site [chemical binding]; other site
1261557003568	Q-loop/lid; other site
1261557003569	ABC transporter signature motif; other site
1261557003570	Walker B; other site
1261557003571	D-loop; other site
1261557003572	H-loop/switch region; other site
1261557003573	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
1261557003574	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
1261557003575	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1261557003576	active site
1261557003577	phosphorylation site [posttranslational modification]
1261557003578	intermolecular recognition site; other site
1261557003579	dimerization interface [polypeptide binding]; other site
1261557003580	LytTr DNA-binding domain; Region: LytTR; pfam04397
1261557003581	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
1261557003582	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1261557003583	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1261557003584	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1261557003585	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1261557003586	Walker A/P-loop; other site
1261557003587	ATP binding site [chemical binding]; other site
1261557003588	Q-loop/lid; other site
1261557003589	ABC transporter signature motif; other site
1261557003590	Walker B; other site
1261557003591	D-loop; other site
1261557003592	H-loop/switch region; other site
1261557003593	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
1261557003594	FtsX-like permease family; Region: FtsX; pfam02687
1261557003595	MarR family; Region: MarR_2; pfam12802
1261557003596	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1261557003597	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1261557003598	dimer interface [polypeptide binding]; other site
1261557003599	conserved gate region; other site
1261557003600	putative PBP binding loops; other site
1261557003601	ABC-ATPase subunit interface; other site
1261557003602	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1261557003603	dimer interface [polypeptide binding]; other site
1261557003604	conserved gate region; other site
1261557003605	ABC-ATPase subunit interface; other site
1261557003606	Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182
1261557003607	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1261557003608	N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857
1261557003609	homodimer interface [polypeptide binding]; other site
1261557003610	Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338
1261557003611	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
1261557003612	active site
1261557003613	homodimer interface [polypeptide binding]; other site
1261557003614	catalytic site [active]
1261557003615	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
1261557003616	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
1261557003617	Ca binding site [ion binding]; other site
1261557003618	active site
1261557003619	catalytic site [active]
1261557003620	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
1261557003621	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
1261557003622	Ca binding site [ion binding]; other site
1261557003623	active site
1261557003624	catalytic site [active]
1261557003625	Protein of unknown function (DUF1211); Region: DUF1211; cl01421
1261557003626	magnesium-transporting ATPase; Provisional; Region: PRK15122
1261557003627	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
1261557003628	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1261557003629	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
1261557003630	Soluble P-type ATPase [General function prediction only]; Region: COG4087
1261557003631	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
1261557003632	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181
1261557003633	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
1261557003634	tetramer interface [polypeptide binding]; other site
1261557003635	TPP-binding site [chemical binding]; other site
1261557003636	heterodimer interface [polypeptide binding]; other site
1261557003637	phosphorylation loop region [posttranslational modification]
1261557003638	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
1261557003639	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
1261557003640	alpha subunit interface [polypeptide binding]; other site
1261557003641	TPP binding site [chemical binding]; other site
1261557003642	heterodimer interface [polypeptide binding]; other site
1261557003643	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1261557003644	dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855
1261557003645	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1261557003646	E3 interaction surface; other site
1261557003647	lipoyl attachment site [posttranslational modification]; other site
1261557003648	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1261557003649	E3 interaction surface; other site
1261557003650	lipoyl attachment site [posttranslational modification]; other site
1261557003651	e3 binding domain; Region: E3_binding; pfam02817
1261557003652	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
1261557003653	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416
1261557003654	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1261557003655	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1261557003656	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1261557003657	Sensory domain found in PocR; Region: PocR; pfam10114
1261557003658	Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936
1261557003659	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1261557003660	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1261557003661	Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371
1261557003662	Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170
1261557003663	dimer interface [polypeptide binding]; other site
1261557003664	active site
1261557003665	metal binding site [ion binding]; metal-binding site
1261557003666	dihydroxyacetone kinase, phosphotransfer subunit; Region: dha_pts; TIGR02364
1261557003667	dihydroxyacetone kinase, DhaK subunit; Region: dhaK1; TIGR02363
1261557003668	Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376
1261557003669	dihydroxyacetone kinase, phosphoprotein-dependent, L subunit; Region: dha_L_ycgS; TIGR02365
1261557003670	"initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827
1261557003671	3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835
1261557003672	dimer interface [polypeptide binding]; other site
1261557003673	active site
1261557003674	putative acyltransferase; Provisional; Region: PRK05790
1261557003675	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
1261557003676	dimer interface [polypeptide binding]; other site
1261557003677	active site
1261557003678	Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644
1261557003679	homodimer interface [polypeptide binding]; other site
1261557003680	catalytic residues [active]
1261557003681	NAD binding site [chemical binding]; other site
1261557003682	substrate binding pocket [chemical binding]; other site
1261557003683	flexible flap; other site
1261557003684	Domain of unknown function DUF20; Region: UPF0118; pfam01594
1261557003685	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
1261557003686	Uncharacterized conserved protein [Function unknown]; Region: COG1434
1261557003687	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
1261557003688	putative active site [active]
1261557003689	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
1261557003690	DNA-binding site [nucleotide binding]; DNA binding site
1261557003691	RNA-binding motif; other site
1261557003692	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1261557003693	Walker A/P-loop; other site
1261557003694	ATP binding site [chemical binding]; other site
1261557003695	ABC transporter; Region: ABC_tran; pfam00005
1261557003696	Q-loop/lid; other site
1261557003697	ABC transporter signature motif; other site
1261557003698	Walker B; other site
1261557003699	D-loop; other site
1261557003700	H-loop/switch region; other site
1261557003701	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1261557003702	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1261557003703	non-specific DNA binding site [nucleotide binding]; other site
1261557003704	salt bridge; other site
1261557003705	sequence-specific DNA binding site [nucleotide binding]; other site
1261557003706	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1261557003707	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1261557003708	putative substrate translocation pore; other site
1261557003709	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1261557003710	metal-dependent hydrolase; Provisional; Region: PRK00685
1261557003711	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
1261557003712	Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109
1261557003713	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1261557003714	DNA-binding site [nucleotide binding]; DNA binding site
1261557003715	DRTGG domain; Region: DRTGG; pfam07085
1261557003716	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596
1261557003717	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
1261557003718	active site 2 [active]
1261557003719	active site 1 [active]
1261557003720	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
1261557003721	DHH family; Region: DHH; pfam01368
1261557003722	DHHA1 domain; Region: DHHA1; pfam02272
1261557003723	Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824
1261557003724	PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274
1261557003725	PhnA protein; Region: PhnA; pfam03831
1261557003726	VanZ like family; Region: VanZ; cl01971
1261557003727	RDD family; Region: RDD; pfam06271
1261557003728	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
1261557003729	DEAD-like helicases superfamily; Region: DEXDc; smart00487
1261557003730	ATP binding site [chemical binding]; other site
1261557003731	Mg++ binding site [ion binding]; other site
1261557003732	motif III; other site
1261557003733	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1261557003734	nucleotide binding region [chemical binding]; other site
1261557003735	ATP-binding site [chemical binding]; other site
1261557003736	Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862
1261557003737	DNA binding site [nucleotide binding]
1261557003738	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
1261557003739	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
1261557003740	motif 1; other site
1261557003741	active site
1261557003742	motif 2; other site
1261557003743	motif 3; other site
1261557003744	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
1261557003745	DHHA1 domain; Region: DHHA1; pfam02272
1261557003746	Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384
1261557003747	Family of unknown function (DUF633); Region: DUF633; pfam04816
1261557003748	Uncharacterized conserved protein [Function unknown]; Region: COG0327
1261557003749	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
1261557003750	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323
1261557003751	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
1261557003752	Uncharacterized conserved protein [Function unknown]; Region: COG0327
1261557003753	peptidase T; Region: peptidase-T; TIGR01882
1261557003754	M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892
1261557003755	metal binding site [ion binding]; metal-binding site
1261557003756	dimer interface [polypeptide binding]; other site
1261557003757	Protein of unknown function (DUF1294); Region: DUF1294; pfam06961
1261557003758	Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706
1261557003759	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
1261557003760	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
1261557003761	GTP binding site; other site
1261557003762	Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226
1261557003763	Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257
1261557003764	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
1261557003765	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
1261557003766	[2Fe-2S] cluster binding site [ion binding]; other site
1261557003767	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
1261557003768	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928
1261557003769	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1261557003770	catalytic loop [active]
1261557003771	iron binding site [ion binding]; other site
1261557003772	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
1261557003773	4Fe-4S dicluster domain; Region: Fer4_10; pfam13237
1261557003774	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
1261557003775	molybdopterin cofactor binding site; other site
1261557003776	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
1261557003777	Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790
1261557003778	molybdopterin cofactor binding site; other site
1261557003779	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
1261557003780	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
1261557003781	dimer interface [polypeptide binding]; other site
1261557003782	putative functional site; other site
1261557003783	putative MPT binding site; other site
1261557003784	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
1261557003785	trimer interface [polypeptide binding]; other site
1261557003786	dimer interface [polypeptide binding]; other site
1261557003787	putative active site [active]
1261557003788	molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666
1261557003789	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1261557003790	FeS/SAM binding site; other site
1261557003791	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
1261557003792	MOSC domain; Region: MOSC; pfam03473
1261557003793	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
1261557003794	MPT binding site; other site
1261557003795	trimer interface [polypeptide binding]; other site
1261557003796	MoeA_like. This domain is similar to a domain found in a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. There this domain is presumed to bind molybdopterin. The exact function of this subgroup is...; Region: MoeA_like; cd03522
1261557003797	putative MPT binding site; other site
1261557003798	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
1261557003799	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
1261557003800	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1261557003801	putative PBP binding loops; other site
1261557003802	ABC-ATPase subunit interface; other site
1261557003803	ATP-binding cassette domain of the molybdenum transport system; Region: ABC_ModC_molybdenum_transporter; cd03297
1261557003804	sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968
1261557003805	Walker A/P-loop; other site
1261557003806	ATP binding site [chemical binding]; other site
1261557003807	Q-loop/lid; other site
1261557003808	ABC transporter signature motif; other site
1261557003809	Walker B; other site
1261557003810	D-loop; other site
1261557003811	H-loop/switch region; other site
1261557003812	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
1261557003813	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
1261557003814	metal-binding site [ion binding]
1261557003815	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1261557003816	haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710
1261557003817	Cell division protein ZapA; Region: ZapA; cl01146
1261557003818	Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286
1261557003819	Colicin V production protein; Region: Colicin_V; pfam02674
1261557003820	recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409
1261557003821	MutS domain III; Region: MutS_III; pfam05192
1261557003822	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1261557003823	Walker A/P-loop; other site
1261557003824	ATP binding site [chemical binding]; other site
1261557003825	Q-loop/lid; other site
1261557003826	ABC transporter signature motif; other site
1261557003827	Walker B; other site
1261557003828	D-loop; other site
1261557003829	H-loop/switch region; other site
1261557003830	Smr domain; Region: Smr; pfam01713
1261557003831	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1261557003832	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1261557003833	catalytic residues [active]
1261557003834	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
1261557003835	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
1261557003836	GIY-YIG motif/motif A; other site
1261557003837	active site
1261557003838	catalytic site [active]
1261557003839	putative DNA binding site [nucleotide binding]; other site
1261557003840	metal binding site [ion binding]; metal-binding site
1261557003841	UvrB/uvrC motif; Region: UVR; pfam02151
1261557003842	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
1261557003843	Protein of unknown function (DUF3884); Region: DUF3884; pfam13024
1261557003844	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152
1261557003845	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1261557003846	Walker A/P-loop; other site
1261557003847	ATP binding site [chemical binding]; other site
1261557003848	Q-loop/lid; other site
1261557003849	ABC transporter signature motif; other site
1261557003850	Walker B; other site
1261557003851	D-loop; other site
1261557003852	H-loop/switch region; other site
1261557003853	Domain of unknown function (DUF4162); Region: DUF4162; pfam13732
1261557003854	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
1261557003855	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1261557003856	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1261557003857	DNA binding site [nucleotide binding]
1261557003858	domain linker motif; other site
1261557003859	Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286
1261557003860	putative dimerization interface [polypeptide binding]; other site
1261557003861	putative ligand binding site [chemical binding]; other site
1261557003862	Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486
1261557003863	Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296
1261557003864	NAD binding site [chemical binding]; other site
1261557003865	sugar binding site [chemical binding]; other site
1261557003866	divalent metal binding site [ion binding]; other site
1261557003867	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1261557003868	dimer interface [polypeptide binding]; other site
1261557003869	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
1261557003870	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1261557003871	ABC transporter; Region: ABC_tran_2; pfam12848
1261557003872	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1261557003873	HI0933-like protein; Region: HI0933_like; pfam03486
1261557003874	glutamate dehydrogenase; Provisional; Region: PRK09414
1261557003875	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
1261557003876	NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313
1261557003877	NAD(P) binding site [chemical binding]; other site
1261557003878	glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097
1261557003879	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
1261557003880	active site
1261557003881	dimer interface [polypeptide binding]; other site
1261557003882	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
1261557003883	dimer interface [polypeptide binding]; other site
1261557003884	active site
1261557003885	flavoprotein NrdI; Provisional; Region: PRK02551
1261557003886	V-type ATP synthase subunit I; Validated; Region: PRK05771
1261557003887	V-type ATP synthase subunit K; Validated; Region: PRK06558
1261557003888	ATP synthase subunit C; Region: ATP-synt_C; pfam00137
1261557003889	ATP synthase subunit C; Region: ATP-synt_C; pfam00137
1261557003890	phosphodiesterase; Provisional; Region: PRK12704
1261557003891	Archaeal/vacuolar-type H+-ATPase subunit C [Energy production and conversion]; Region: NtpC; COG1527
1261557003892	V-type ATP synthase subunit C; Provisional; Region: PRK01198; cl00660
1261557003893	V-type ATP synthase subunit F; Provisional; Region: PRK01395
1261557003894	V-type ATP synthase subunit A; Provisional; Region: PRK04192
1261557003895	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
1261557003896	V/A-type ATP synthase catalytic subunit A. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction.  The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_A; cd01134
1261557003897	Walker A motif/ATP binding site; other site
1261557003898	Walker B motif; other site
1261557003899	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
1261557003900	V-type ATP synthase subunit B; Provisional; Region: PRK04196
1261557003901	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
1261557003902	V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_B; cd01135
1261557003903	Walker A motif homologous position; other site
1261557003904	Walker B motif; other site
1261557003905	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
1261557003906	V-type ATP synthase subunit D; Reviewed; Region: PRK00373
1261557003907	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
1261557003908	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1261557003909	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1261557003910	DNA binding residues [nucleotide binding]
1261557003911	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
1261557003912	Firmicute fructose-1,6-bisphosphatase; Region: FBPase_2; pfam06874
1261557003913	diaminopimelate decarboxylase; Region: lysA; TIGR01048
1261557003914	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
1261557003915	active site
1261557003916	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1261557003917	substrate binding site [chemical binding]; other site
1261557003918	catalytic residues [active]
1261557003919	dimer interface [polypeptide binding]; other site
1261557003920	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1261557003921	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1261557003922	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
1261557003923	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
1261557003924	L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319
1261557003925	active site
1261557003926	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
1261557003927	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
1261557003928	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
1261557003929	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
1261557003930	peptide binding site [polypeptide binding]; other site
1261557003931	transcriptional antiterminator BglG; Provisional; Region: PRK09772
1261557003932	CAT RNA binding domain; Region: CAT_RBD; smart01061
1261557003933	PRD domain; Region: PRD; pfam00874
1261557003934	PRD domain; Region: PRD; pfam00874
1261557003935	PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998
1261557003936	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
1261557003937	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1261557003938	active site turn [active]
1261557003939	phosphorylation site [posttranslational modification]
1261557003940	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
1261557003941	HPr interaction site; other site
1261557003942	glycerol kinase (GK) interaction site [polypeptide binding]; other site
1261557003943	active site
1261557003944	phosphorylation site [posttranslational modification]
1261557003945	HTH domain; Region: HTH_11; cl17392
1261557003946	PRD domain; Region: PRD; pfam00874
1261557003947	PRD domain; Region: PRD; pfam00874
1261557003948	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
1261557003949	active site
1261557003950	P-loop; other site
1261557003951	phosphorylation site [posttranslational modification]
1261557003952	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163
1261557003953	active site
1261557003954	phosphorylation site [posttranslational modification]
1261557003955	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
1261557003956	active site
1261557003957	P-loop; other site
1261557003958	phosphorylation site [posttranslational modification]
1261557003959	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1261557003960	active site
1261557003961	phosphorylation site [posttranslational modification]
1261557003962	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
1261557003963	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
1261557003964	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
1261557003965	substrate binding site [chemical binding]; other site
1261557003966	hexamer interface [polypeptide binding]; other site
1261557003967	metal binding site [ion binding]; metal-binding site
1261557003968	Lysozyme-like; Region: Lysozyme_like; pfam13702
1261557003969	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
1261557003970	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1261557003971	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1261557003972	motif II; other site
1261557003973	DNA primase, catalytic core; Region: dnaG; TIGR01391
1261557003974	CHC2 zinc finger; Region: zf-CHC2; pfam01807
1261557003975	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
1261557003976	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
1261557003977	active site
1261557003978	metal binding site [ion binding]; metal-binding site
1261557003979	interdomain interaction site; other site
1261557003980	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
1261557003981	RNA polymerase sigma factor RpoD; Validated; Region: PRK09210
1261557003982	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
1261557003983	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
1261557003984	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1261557003985	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
1261557003986	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1261557003987	DNA binding residues [nucleotide binding]
1261557003988	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
1261557003989	Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996
1261557003990	S1 domain; Region: S1_2; pfam13509
1261557003991	ferric uptake regulator; Provisional; Region: fur; PRK09462
1261557003992	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
1261557003993	metal binding site 2 [ion binding]; metal-binding site
1261557003994	putative DNA binding helix; other site
1261557003995	metal binding site 1 [ion binding]; metal-binding site
1261557003996	dimer interface [polypeptide binding]; other site
1261557003997	structural Zn2+ binding site [ion binding]; other site
1261557003998	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
1261557003999	glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534
1261557004000	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
1261557004001	GTPase CgtA; Reviewed; Region: obgE; PRK12297
1261557004002	GTP1/OBG; Region: GTP1_OBG; pfam01018
1261557004003	Obg GTPase; Region: Obg; cd01898
1261557004004	G1 box; other site
1261557004005	GTP/Mg2+ binding site [chemical binding]; other site
1261557004006	Switch I region; other site
1261557004007	G2 box; other site
1261557004008	G3 box; other site
1261557004009	Switch II region; other site
1261557004010	G4 box; other site
1261557004011	G5 box; other site
1261557004012	Domain of unknown function (DUF1967); Region: DUF1967; pfam09269
1261557004013	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
1261557004014	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
1261557004015	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1261557004016	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1261557004017	WHG domain; Region: WHG; pfam13305
1261557004018	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
1261557004019	Helix-turn-helix domain; Region: HTH_38; pfam13936
1261557004020	Integrase core domain; Region: rve; pfam00665
1261557004021	Protein of unknown function (DUF1093); Region: DUF1093; cl02185
1261557004022	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197
1261557004023	active site
1261557004024	Uncharacterized conserved protein [Function unknown]; Region: COG3589
1261557004025	Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913
1261557004026	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1261557004027	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
1261557004028	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1261557004029	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
1261557004030	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
1261557004031	active site
1261557004032	Int/Topo IB signature motif; other site
1261557004033	segregation and condensation protein A; Reviewed; Region: scpA; PRK00104
1261557004034	Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079
1261557004035	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
1261557004036	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1261557004037	RNA binding surface [nucleotide binding]; other site
1261557004038	Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
1261557004039	active site
1261557004040	Predicted membrane protein [Function unknown]; Region: COG3601
1261557004041	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
1261557004042	Predicted membrane protein [Function unknown]; Region: COG4640
1261557004043	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
1261557004044	Protein of unknown function (DUF1271); Region: DUF1271; cl01443
1261557004045	4Fe-4S single cluster domain; Region: Fer4_15; pfam13459
1261557004046	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955
1261557004047	Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514
1261557004048	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1261557004049	ATP binding site [chemical binding]; other site
1261557004050	putative Mg++ binding site [ion binding]; other site
1261557004051	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1261557004052	nucleotide binding region [chemical binding]; other site
1261557004053	ATP-binding site [chemical binding]; other site
1261557004054	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1261557004055	cytidylate kinase; Provisional; Region: cmk; PRK00023
1261557004056	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
1261557004057	CMP-binding site; other site
1261557004058	The sites determining sugar specificity; other site
1261557004059	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676
1261557004060	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
1261557004061	RNA binding site [nucleotide binding]; other site
1261557004062	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
1261557004063	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
1261557004064	RNA binding site [nucleotide binding]; other site
1261557004065	S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692
1261557004066	RNA binding site [nucleotide binding]; other site
1261557004067	GTP-binding protein Der; Reviewed; Region: PRK00093
1261557004068	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
1261557004069	G1 box; other site
1261557004070	GTP/Mg2+ binding site [chemical binding]; other site
1261557004071	Switch I region; other site
1261557004072	G2 box; other site
1261557004073	Switch II region; other site
1261557004074	G3 box; other site
1261557004075	G4 box; other site
1261557004076	G5 box; other site
1261557004077	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
1261557004078	G1 box; other site
1261557004079	GTP/Mg2+ binding site [chemical binding]; other site
1261557004080	Switch I region; other site
1261557004081	G2 box; other site
1261557004082	G3 box; other site
1261557004083	Switch II region; other site
1261557004084	G4 box; other site
1261557004085	G5 box; other site
1261557004086	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
1261557004087	IHF dimer interface [polypeptide binding]; other site
1261557004088	IHF - DNA interface [nucleotide binding]; other site
1261557004089	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1261557004090	binding surface
1261557004091	TPR motif; other site
1261557004092	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
1261557004093	TPR motif; other site
1261557004094	binding surface
1261557004095	hypothetical protein; Provisional; Region: PRK03636
1261557004096	UPF0302 domain; Region: UPF0302; pfam08864
1261557004097	A short protein domain of unknown function; Region: IDEAL; smart00914
1261557004098	Uncharacterized conserved protein [Function unknown]; Region: COG1284
1261557004099	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
1261557004100	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
1261557004101	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531
1261557004102	homodimer interface [polypeptide binding]; other site
1261557004103	metal binding site [ion binding]; metal-binding site
1261557004104	dihydrodipicolinate reductase; Provisional; Region: PRK00048
1261557004105	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
1261557004106	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
1261557004107	tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299
1261557004108	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
1261557004109	active site
1261557004110	NTP binding site [chemical binding]; other site
1261557004111	metal binding triad [ion binding]; metal-binding site
1261557004112	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
1261557004113	tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735
1261557004114	Predicted thioesterase [General function prediction only]; Region: COG5496
1261557004115	shikimate 5-dehydrogenase; Provisional; Region: PRK12548
1261557004116	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
1261557004117	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
1261557004118	shikimate binding site; other site
1261557004119	NAD(P) binding site [chemical binding]; other site
1261557004120	3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673
1261557004121	phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361
1261557004122	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
1261557004123	active site
1261557004124	dimer interface [polypeptide binding]; other site
1261557004125	metal binding site [ion binding]; metal-binding site
1261557004126	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
1261557004127	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
1261557004128	Tetramer interface [polypeptide binding]; other site
1261557004129	active site
1261557004130	FMN-binding site [chemical binding]; other site
1261557004131	prephenate dehydrogenase; Validated; Region: PRK06545
1261557004132	prephenate dehydrogenase; Validated; Region: PRK08507
1261557004133	C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909
1261557004134	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
1261557004135	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
1261557004136	active site
1261557004137	hinge; other site
1261557004138	shikimate kinase; Reviewed; Region: aroK; PRK00131
1261557004139	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
1261557004140	ADP binding site [chemical binding]; other site
1261557004141	magnesium binding site [ion binding]; other site
1261557004142	putative shikimate binding site; other site
1261557004143	prephenate dehydratase; Provisional; Region: PRK11898
1261557004144	Prephenate dehydratase; Region: PDT; pfam00800
1261557004145	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
1261557004146	putative L-Phe binding site [chemical binding]; other site
1261557004147	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816
1261557004148	EDD domain protein, DegV family; Region: DegV; TIGR00762
1261557004149	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
1261557004150	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
1261557004151	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
1261557004152	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1261557004153	Walker A/P-loop; other site
1261557004154	ATP binding site [chemical binding]; other site
1261557004155	Q-loop/lid; other site
1261557004156	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1261557004157	ABC transporter signature motif; other site
1261557004158	Walker B; other site
1261557004159	D-loop; other site
1261557004160	ABC transporter; Region: ABC_tran_2; pfam12848
1261557004161	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1261557004162	thymidylate synthase; Region: thym_sym; TIGR03284
1261557004163	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
1261557004164	dimerization interface [polypeptide binding]; other site
1261557004165	active site
1261557004166	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
1261557004167	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
1261557004168	folate binding site [chemical binding]; other site
1261557004169	NADP+ binding site [chemical binding]; other site
1261557004170	epoxyqueuosine reductase; Region: TIGR00276
1261557004171	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
1261557004172	HEAT repeat; Region: HEAT; pfam02985
1261557004173	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1261557004174	putative DNA binding site [nucleotide binding]; other site
1261557004175	LexA repressor; Validated; Region: PRK00215
1261557004176	putative Zn2+ binding site [ion binding]; other site
1261557004177	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
1261557004178	Catalytic site [active]
1261557004179	hypothetical protein; Provisional; Region: PRK02539
1261557004180	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
1261557004181	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
1261557004182	TPP-binding site [chemical binding]; other site
1261557004183	dimer interface [polypeptide binding]; other site
1261557004184	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
1261557004185	PYR/PP interface [polypeptide binding]; other site
1261557004186	dimer interface [polypeptide binding]; other site
1261557004187	TPP binding site [chemical binding]; other site
1261557004188	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1261557004189	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1261557004190	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
1261557004191	putative substrate translocation pore; other site
1261557004192	Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705
1261557004193	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1261557004194	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
1261557004195	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
1261557004196	dimer interface [polypeptide binding]; other site
1261557004197	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1261557004198	catalytic residue [active]
1261557004199	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
1261557004200	metal binding site 2 [ion binding]; metal-binding site
1261557004201	putative DNA binding helix; other site
1261557004202	metal binding site 1 [ion binding]; metal-binding site
1261557004203	dimer interface [polypeptide binding]; other site
1261557004204	structural Zn2+ binding site [ion binding]; other site
1261557004205	coenzyme A disulfide reductase; Reviewed; Region: PRK09564
1261557004206	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1261557004207	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1261557004208	Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535
1261557004209	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672
1261557004210	nudix motif; other site
1261557004211	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1261557004212	Coenzyme A binding pocket [chemical binding]; other site
1261557004213	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1261557004214	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1261557004215	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1261557004216	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1261557004217	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1261557004218	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1261557004219	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1261557004220	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1261557004221	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1261557004222	Walker A/P-loop; other site
1261557004223	ATP binding site [chemical binding]; other site
1261557004224	Q-loop/lid; other site
1261557004225	ABC transporter signature motif; other site
1261557004226	Walker B; other site
1261557004227	D-loop; other site
1261557004228	H-loop/switch region; other site
1261557004229	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1261557004230	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1261557004231	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
1261557004232	Walker A/P-loop; other site
1261557004233	ATP binding site [chemical binding]; other site
1261557004234	Q-loop/lid; other site
1261557004235	ABC transporter signature motif; other site
1261557004236	Walker B; other site
1261557004237	D-loop; other site
1261557004238	H-loop/switch region; other site
1261557004239	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
1261557004240	nudix motif; other site
1261557004241	Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506
1261557004242	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
1261557004243	Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156
1261557004244	heme binding pocket [chemical binding]; other site
1261557004245	tetramer interface [polypeptide binding]; other site
1261557004246	NADPH binding site [chemical binding]; other site
1261557004247	Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415
1261557004248	DNA photolyase; Region: DNA_photolyase; pfam00875
1261557004249	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1261557004250	non-specific DNA binding site [nucleotide binding]; other site
1261557004251	salt bridge; other site
1261557004252	sequence-specific DNA binding site [nucleotide binding]; other site
1261557004253	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1261557004254	PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996
1261557004255	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1261557004256	active site turn [active]
1261557004257	phosphorylation site [posttranslational modification]
1261557004258	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
1261557004259	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162
1261557004260	HPr interaction site; other site
1261557004261	glycerol kinase (GK) interaction site [polypeptide binding]; other site
1261557004262	active site
1261557004263	phosphorylation site [posttranslational modification]
1261557004264	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
1261557004265	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
1261557004266	Ca binding site [ion binding]; other site
1261557004267	active site
1261557004268	catalytic site [active]
1261557004269	sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322
1261557004270	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
1261557004271	substrate binding [chemical binding]; other site
1261557004272	active site
1261557004273	Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244
1261557004274	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1261557004275	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1261557004276	DNA binding site [nucleotide binding]
1261557004277	domain linker motif; other site
1261557004278	Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291
1261557004279	dimerization interface [polypeptide binding]; other site
1261557004280	ligand binding site [chemical binding]; other site
1261557004281	sodium binding site [ion binding]; other site
1261557004282	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
1261557004283	beta-galactosidase; Region: BGL; TIGR03356
1261557004284	PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995
1261557004285	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1261557004286	active site turn [active]
1261557004287	phosphorylation site [posttranslational modification]
1261557004288	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
1261557004289	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162
1261557004290	HPr interaction site; other site
1261557004291	glycerol kinase (GK) interaction site [polypeptide binding]; other site
1261557004292	active site
1261557004293	phosphorylation site [posttranslational modification]
1261557004294	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
1261557004295	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1261557004296	active site
1261557004297	metal binding site [ion binding]; metal-binding site
1261557004298	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
1261557004299	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1261557004300	dimer interface [polypeptide binding]; other site
1261557004301	conserved gate region; other site
1261557004302	putative PBP binding loops; other site
1261557004303	ABC-ATPase subunit interface; other site
1261557004304	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
1261557004305	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
1261557004306	ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638
1261557004307	ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256
1261557004308	Walker A/P-loop; other site
1261557004309	ATP binding site [chemical binding]; other site
1261557004310	Q-loop/lid; other site
1261557004311	ABC transporter signature motif; other site
1261557004312	Walker B; other site
1261557004313	D-loop; other site
1261557004314	H-loop/switch region; other site
1261557004315	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974
1261557004316	DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402
1261557004317	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1261557004318	ligand binding site [chemical binding]; other site
1261557004319	flexible hinge region; other site
1261557004320	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
1261557004321	cardiolipin synthase; Region: bac_cardiolipin; TIGR04265
1261557004322	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
1261557004323	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
1261557004324	putative active site [active]
1261557004325	catalytic site [active]
1261557004326	catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112
1261557004327	putative active site [active]
1261557004328	catalytic site [active]
1261557004329	hypothetical protein; Provisional; Region: PRK04164
1261557004330	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
1261557004331	Domain of unknown function (DUF1803); Region: DUF1803; pfam08820
1261557004332	putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427
1261557004333	DHH family; Region: DHH; pfam01368
1261557004334	DHHA2 domain; Region: DHHA2; pfam02833
1261557004335	pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493
1261557004336	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1261557004337	FeS/SAM binding site; other site
1261557004338	formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255
1261557004339	Pyruvate formate lyase 1; Region: PFL1; cd01678
1261557004340	coenzyme A binding site [chemical binding]; other site
1261557004341	active site
1261557004342	catalytic residues [active]
1261557004343	glycine loop; other site
1261557004344	DNA topoisomerase IV subunit A; Validated; Region: PRK05561
1261557004345	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
1261557004346	CAP-like domain; other site
1261557004347	active site
1261557004348	primary dimer interface [polypeptide binding]; other site
1261557004349	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1261557004350	DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559
1261557004351	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1261557004352	ATP binding site [chemical binding]; other site
1261557004353	Mg2+ binding site [ion binding]; other site
1261557004354	G-X-G motif; other site
1261557004355	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
1261557004356	anchoring element; other site
1261557004357	dimer interface [polypeptide binding]; other site
1261557004358	ATP binding site [chemical binding]; other site
1261557004359	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
1261557004360	active site
1261557004361	putative metal-binding site [ion binding]; other site
1261557004362	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
1261557004363	Predicted CoA-binding protein [General function prediction only]; Region: COG1832
1261557004364	Ethanolamine utilisation protein EutQ; Region: EutQ; pfam06249
1261557004365	ethanolamine utilization protein EutQ; Provisional; Region: PRK15457
1261557004366	ethanolamine utilization protein EutH; Provisional; Region: PRK15086
1261557004367	Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614
1261557004368	Hexamer/Pentamer interface [polypeptide binding]; other site
1261557004369	central pore; other site
1261557004370	ethanolamine utilization protein; Region: eut_hyp; TIGR02536
1261557004371	propanediol utilization phosphotransacylase; Provisional; Region: PRK15070
1261557004372	Propanediol utilisation protein PduL; Region: PduL; pfam06130
1261557004373	Propanediol utilisation protein PduL; Region: PduL; pfam06130
1261557004374	Cobalamin adenosyltransferase; Region: Cob_adeno_trans; cl00920
1261557004375	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
1261557004376	1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059
1261557004377	Hexamer interface [polypeptide binding]; other site
1261557004378	Putative hexagonal pore residue; other site
1261557004379	Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122
1261557004380	putative catalytic cysteine [active]
1261557004381	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
1261557004382	Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045
1261557004383	Hexamer interface [polypeptide binding]; other site
1261557004384	Hexagonal pore residue; other site
1261557004385	ethanolamine utilization protein EutL; Provisional; Region: PRK15405
1261557004386	ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_EutL_repeat1; cd07049
1261557004387	putative hexamer interface [polypeptide binding]; other site
1261557004388	putative hexagonal pore; other site
1261557004389	ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_EutL_repeat2; cd07050
1261557004390	putative hexamer interface [polypeptide binding]; other site
1261557004391	putative hexagonal pore; other site
1261557004392	Ethanolamine ammonia-lyase, small subunit [Amino acid transport and metabolism]; Region: EutC; COG4302
1261557004393	ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067
1261557004394	Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751
1261557004395	reactivating factor for ethanolamine ammonia lyase; Provisional; Region: eutA; PRK10719
1261557004396	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
1261557004397	Signal transduction histidine kinase; Region: H_kinase_N; pfam12282
1261557004398	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
1261557004399	Histidine kinase; Region: HisKA_2; pfam07568
1261557004400	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1261557004401	ATP binding site [chemical binding]; other site
1261557004402	Mg2+ binding site [ion binding]; other site
1261557004403	G-X-G motif; other site
1261557004404	Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707
1261557004405	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1261557004406	active site
1261557004407	phosphorylation site [posttranslational modification]
1261557004408	intermolecular recognition site; other site
1261557004409	dimerization interface [polypeptide binding]; other site
1261557004410	ANTAR domain; Region: ANTAR; pfam03861
1261557004411	1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046
1261557004412	putative hexamer interface [polypeptide binding]; other site
1261557004413	putative hexagonal pore; other site
1261557004414	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
1261557004415	1,3-propanediol dehydrogenase (PPD) catalyzes the reduction of 3-hydroxypropionaldehyde (3-HPA) to 1,3-propanediol in glycerol metabolism; Region: PDD; cd08180
1261557004416	putative active site [active]
1261557004417	metal binding site [ion binding]; metal-binding site
1261557004418	ATP:cob(I)alamin adenosyltransferase; Region: PduO_Nterm; TIGR00636
1261557004419	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
1261557004420	G1 box; other site
1261557004421	GTP/Mg2+ binding site [chemical binding]; other site
1261557004422	G2 box; other site
1261557004423	Switch I region; other site
1261557004424	G3 box; other site
1261557004425	Switch II region; other site
1261557004426	G4 box; other site
1261557004427	G5 box; other site
1261557004428	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
1261557004429	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
1261557004430	Walker A/P-loop; other site
1261557004431	ATP binding site [chemical binding]; other site
1261557004432	Q-loop/lid; other site
1261557004433	ABC transporter signature motif; other site
1261557004434	Walker B; other site
1261557004435	D-loop; other site
1261557004436	H-loop/switch region; other site
1261557004437	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1261557004438	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1261557004439	ABC-ATPase subunit  interface; other site
1261557004440	dimer interface [polypeptide binding]; other site
1261557004441	putative PBP binding regions; other site
1261557004442	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
1261557004443	Periplasmic binding protein YvrC.  These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143
1261557004444	putative binding site residues; other site
1261557004445	Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410
1261557004446	Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024
1261557004447	active site
1261557004448	catalytic residues [active]
1261557004449	CodY GAF-like domain; Region: CodY; pfam06018
1261557004450	GTP-sensing transcriptional pleiotropic repressor CodY; Region: codY_Gpos; TIGR02787
1261557004451	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1261557004452	putative DNA binding site [nucleotide binding]; other site
1261557004453	putative Zn2+ binding site [ion binding]; other site
1261557004454	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
1261557004455	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
1261557004456	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1261557004457	Walker A motif; other site
1261557004458	ATP binding site [chemical binding]; other site
1261557004459	AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724
1261557004460	Walker B motif; other site
1261557004461	arginine finger; other site
1261557004462	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
1261557004463	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
1261557004464	active site
1261557004465	HslU subunit interaction site [polypeptide binding]; other site
1261557004466	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
1261557004467	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
1261557004468	active site
1261557004469	Int/Topo IB signature motif; other site
1261557004470	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
1261557004471	Glucose inhibited division protein A; Region: GIDA; pfam01134
1261557004472	DNA topoisomerase I; Validated; Region: PRK05582
1261557004473	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
1261557004474	active site
1261557004475	interdomain interaction site; other site
1261557004476	putative metal-binding site [ion binding]; other site
1261557004477	nucleotide binding site [chemical binding]; other site
1261557004478	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
1261557004479	domain I; other site
1261557004480	DNA binding groove [nucleotide binding]
1261557004481	phosphate binding site [ion binding]; other site
1261557004482	domain II; other site
1261557004483	domain III; other site
1261557004484	nucleotide binding site [chemical binding]; other site
1261557004485	catalytic site [active]
1261557004486	domain IV; other site
1261557004487	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
1261557004488	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
1261557004489	CAAX protease self-immunity; Region: Abi; pfam02517
1261557004490	DNA protecting protein DprA; Region: dprA; TIGR00732
1261557004491	DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
1261557004492	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
1261557004493	RNA/DNA hybrid binding site [nucleotide binding]; other site
1261557004494	active site
1261557004495	GTPase YlqF; Reviewed; Region: rbgA; PRK09563
1261557004496	Circularly permuted YlqF GTPase; Region: YlqF; cd01856
1261557004497	GTP/Mg2+ binding site [chemical binding]; other site
1261557004498	G4 box; other site
1261557004499	G5 box; other site
1261557004500	G1 box; other site
1261557004501	Switch I region; other site
1261557004502	G2 box; other site
1261557004503	G3 box; other site
1261557004504	Switch II region; other site
1261557004505	2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522
1261557004506	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
1261557004507	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
1261557004508	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1261557004509	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1261557004510	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1261557004511	dimerization interface [polypeptide binding]; other site
1261557004512	Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641
1261557004513	Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303
1261557004514	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
1261557004515	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1261557004516	E3 interaction surface; other site
1261557004517	lipoyl attachment site [posttranslational modification]; other site
1261557004518	e3 binding domain; Region: E3_binding; pfam02817
1261557004519	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
1261557004520	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
1261557004521	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
1261557004522	alpha subunit interface [polypeptide binding]; other site
1261557004523	TPP binding site [chemical binding]; other site
1261557004524	heterodimer interface [polypeptide binding]; other site
1261557004525	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1261557004526	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071
1261557004527	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
1261557004528	tetramer interface [polypeptide binding]; other site
1261557004529	TPP-binding site [chemical binding]; other site
1261557004530	heterodimer interface [polypeptide binding]; other site
1261557004531	phosphorylation loop region [posttranslational modification]
1261557004532	dihydrolipoamide dehydrogenase; Validated; Region: PRK05976
1261557004533	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1261557004534	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1261557004535	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
1261557004536	nucleotide binding site [chemical binding]; other site
1261557004537	Acetokinase family; Region: Acetate_kinase; cl17229
1261557004538	branched-chain phosphotransacylase; Region: branched_ptb; TIGR02709
1261557004539	Uncharacterized conserved protein [Function unknown]; Region: COG1434
1261557004540	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
1261557004541	putative active site [active]
1261557004542	TraX protein; Region: TraX; cl05434
1261557004543	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
1261557004544	classical (c) SDRs; Region: SDR_c; cd05233
1261557004545	NAD(P) binding site [chemical binding]; other site
1261557004546	active site
1261557004547	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1261557004548	MarR family; Region: MarR; pfam01047
1261557004549	N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
1261557004550	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1261557004551	Zn binding site [ion binding]; other site
1261557004552	C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347
1261557004553	Zn binding site [ion binding]; other site
1261557004554	Predicted esterase [General function prediction only]; Region: COG0400
1261557004555	putative hydrolase; Provisional; Region: PRK11460
1261557004556	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
1261557004557	alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289
1261557004558	putative NAD(P) binding site [chemical binding]; other site
1261557004559	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1261557004560	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
1261557004561	FtsX-like permease family; Region: FtsX; pfam02687
1261557004562	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1261557004563	Walker A/P-loop; other site
1261557004564	ATP binding site [chemical binding]; other site
1261557004565	ABC transporter; Region: ABC_tran; pfam00005
1261557004566	Q-loop/lid; other site
1261557004567	ABC transporter signature motif; other site
1261557004568	Walker B; other site
1261557004569	D-loop; other site
1261557004570	H-loop/switch region; other site
1261557004571	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
1261557004572	Helix-turn-helix domain; Region: HTH_38; pfam13936
1261557004573	Integrase core domain; Region: rve; pfam00665
1261557004574	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1261557004575	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1261557004576	Walker A/P-loop; other site
1261557004577	ATP binding site [chemical binding]; other site
1261557004578	Q-loop/lid; other site
1261557004579	ABC transporter signature motif; other site
1261557004580	Walker B; other site
1261557004581	D-loop; other site
1261557004582	H-loop/switch region; other site
1261557004583	Predicted transcriptional regulators [Transcription]; Region: COG1725
1261557004584	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1261557004585	DNA-binding site [nucleotide binding]; DNA binding site
1261557004586	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
1261557004587	The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462
1261557004588	Catalytic site [active]
1261557004589	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
1261557004590	Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793
1261557004591	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
1261557004592	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
1261557004593	protein binding site [polypeptide binding]; other site
1261557004594	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
1261557004595	Catalytic dyad [active]
1261557004596	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
1261557004597	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
1261557004598	hypothetical protein; Provisional; Region: PRK13672
1261557004599	methionine sulfoxide reductase A; Provisional; Region: PRK14054
1261557004600	Uncharacterized protein conserved in bacteria (DUF2140); Region: DUF2140; pfam09911
1261557004601	Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506
1261557004602	active site
1261557004603	catalytic triad [active]
1261557004604	oxyanion hole [active]
1261557004605	EDD domain protein, DegV family; Region: DegV; TIGR00762
1261557004606	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
1261557004607	Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272
1261557004608	channel protein, hemolysin III family; Region: hlyIII; TIGR01065
1261557004609	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1261557004610	active site
1261557004611	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
1261557004612	DHH family; Region: DHH; pfam01368
1261557004613	DHHA1 domain; Region: DHHA1; pfam02272
1261557004614	Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; pfam10141
1261557004615	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
1261557004616	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1261557004617	NAD(P) binding site [chemical binding]; other site
1261557004618	active site
1261557004619	ribonuclease Z; Region: RNase_Z; TIGR02651
1261557004620	Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837
1261557004621	KH domain; Region: KH_4; pfam13083
1261557004622	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
1261557004623	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1261557004624	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1261557004625	Coenzyme A binding pocket [chemical binding]; other site
1261557004626	Predicted flavoprotein [General function prediction only]; Region: COG0431
1261557004627	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1261557004628	Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106
1261557004629	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
1261557004630	DNA binding residues [nucleotide binding]
1261557004631	dimer interface [polypeptide binding]; other site
1261557004632	TipAS antibiotic-recognition domain; Region: TipAS; pfam07739
1261557004633	signal recognition particle protein; Provisional; Region: PRK10867
1261557004634	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
1261557004635	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
1261557004636	P loop; other site
1261557004637	GTP binding site [chemical binding]; other site
1261557004638	Signal peptide binding domain; Region: SRP_SPB; pfam02978
1261557004639	putative DNA-binding protein; Validated; Region: PRK00118
1261557004640	Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297
1261557004641	Uncharacterized conserved protein [Function unknown]; Region: COG1683
1261557004642	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1261557004643	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1261557004644	active site
1261557004645	phosphorylation site [posttranslational modification]
1261557004646	intermolecular recognition site; other site
1261557004647	dimerization interface [polypeptide binding]; other site
1261557004648	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1261557004649	DNA binding site [nucleotide binding]
1261557004650	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
1261557004651	PAS domain; Region: PAS; smart00091
1261557004652	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1261557004653	dimer interface [polypeptide binding]; other site
1261557004654	phosphorylation site [posttranslational modification]
1261557004655	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1261557004656	ATP binding site [chemical binding]; other site
1261557004657	Mg2+ binding site [ion binding]; other site
1261557004658	G-X-G motif; other site
1261557004659	PBP superfamily domain; Region: PBP_like_2; cl17296
1261557004660	aromatic amino acid aminotransferase; Validated; Region: PRK07309
1261557004661	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1261557004662	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1261557004663	homodimer interface [polypeptide binding]; other site
1261557004664	catalytic residue [active]
1261557004665	Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383
1261557004666	N-terminal catalytic domain of SPGH38, a putative alpha-mannosidase of Streptococcus pyogenes, and its prokaryotic homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_SpGH38_like; cd10814
1261557004667	active site
1261557004668	metal binding site [ion binding]; metal-binding site
1261557004669	homodimer interface [polypeptide binding]; other site
1261557004670	catalytic site [active]
1261557004671	Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872
1261557004672	Uncharacterized conserved protein [Function unknown]; Region: COG3538
1261557004673	Protein of unknown function (DUF1237); Region: DUF1237; pfam06824
1261557004674	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
1261557004675	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1261557004676	DNA-binding site [nucleotide binding]; DNA binding site
1261557004677	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1261557004678	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
1261557004679	ligand binding site [chemical binding]; other site
1261557004680	dimerization interface [polypeptide binding]; other site
1261557004681	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1261557004682	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1261557004683	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1261557004684	dimerization interface [polypeptide binding]; other site
1261557004685	Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124
1261557004686	active site
1261557004687	zinc binding site [ion binding]; other site
1261557004688	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1261557004689	active site
1261557004690	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
1261557004691	active site
1261557004692	dimer interface [polypeptide binding]; other site
1261557004693	dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037
1261557004694	Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740
1261557004695	heterodimer interface [polypeptide binding]; other site
1261557004696	active site
1261557004697	FMN binding site [chemical binding]; other site
1261557004698	homodimer interface [polypeptide binding]; other site
1261557004699	substrate binding site [chemical binding]; other site
1261557004700	dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054
1261557004701	FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218
1261557004702	FAD binding pocket [chemical binding]; other site
1261557004703	FAD binding motif [chemical binding]; other site
1261557004704	phosphate binding motif [ion binding]; other site
1261557004705	beta-alpha-beta structure motif; other site
1261557004706	NAD binding pocket [chemical binding]; other site
1261557004707	Iron coordination center [ion binding]; other site
1261557004708	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
1261557004709	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1261557004710	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
1261557004711	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
1261557004712	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1261557004713	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1261557004714	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
1261557004715	IMP binding site; other site
1261557004716	dimer interface [polypeptide binding]; other site
1261557004717	interdomain contacts; other site
1261557004718	partial ornithine binding site; other site
1261557004719	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
1261557004720	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
1261557004721	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
1261557004722	catalytic site [active]
1261557004723	subunit interface [polypeptide binding]; other site
1261557004724	dihydroorotase; Validated; Region: pyrC; PRK09357
1261557004725	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
1261557004726	active site
1261557004727	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
1261557004728	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
1261557004729	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
1261557004730	uracil transporter; Provisional; Region: PRK10720
1261557004731	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
1261557004732	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1261557004733	active site
1261557004734	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
1261557004735	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1261557004736	RNA binding surface [nucleotide binding]; other site
1261557004737	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
1261557004738	active site
1261557004739	lipoprotein signal peptidase; Provisional; Region: PRK14797
1261557004740	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
1261557004741	formate--tetrahydrofolate ligase; Provisional; Region: PRK13505
1261557004742	Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477
1261557004743	Potassium binding sites [ion binding]; other site
1261557004744	Cesium cation binding sites [ion binding]; other site
1261557004745	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
1261557004746	DNA-binding site [nucleotide binding]; DNA binding site
1261557004747	RNA-binding motif; other site
1261557004748	RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279
1261557004749	RNA/DNA hybrid binding site [nucleotide binding]; other site
1261557004750	active site
1261557004751	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
1261557004752	putative deacylase active site [active]
1261557004753	3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710
1261557004754	Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502
1261557004755	active site
1261557004756	catalytic residue [active]
1261557004757	dimer interface [polypeptide binding]; other site
1261557004758	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1261557004759	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1261557004760	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
1261557004761	Walker A/P-loop; other site
1261557004762	ATP binding site [chemical binding]; other site
1261557004763	Q-loop/lid; other site
1261557004764	ABC transporter signature motif; other site
1261557004765	Walker B; other site
1261557004766	D-loop; other site
1261557004767	H-loop/switch region; other site
1261557004768	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1261557004769	putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789
1261557004770	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1261557004771	Walker A/P-loop; other site
1261557004772	ATP binding site [chemical binding]; other site
1261557004773	Q-loop/lid; other site
1261557004774	ABC transporter signature motif; other site
1261557004775	Walker B; other site
1261557004776	D-loop; other site
1261557004777	H-loop/switch region; other site
1261557004778	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3763
1261557004779	endonuclease IV; Provisional; Region: PRK01060
1261557004780	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
1261557004781	AP (apurinic/apyrimidinic) site pocket; other site
1261557004782	DNA interaction; other site
1261557004783	Metal-binding active site; metal-binding site
1261557004784	Domain of unknown function (DU1801); Region: DUF1801; pfam08818
1261557004785	Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376
1261557004786	Bacteriophage peptidoglycan hydrolase; Region: Amidase_5; pfam05382
1261557004787	Holin family; Region: Phage_holin_4; cl01989
1261557004788	Prophage endopeptidase tail; Region: Prophage_tail; cl12123
1261557004789	Chaperone of endosialidase; Region: Peptidase_S74; pfam13884
1261557004790	Phage-related protein [Function unknown]; Region: COG4722
1261557004791	Phage tail protein; Region: Sipho_tail; cl17486
1261557004792	tape measure domain; Region: tape_meas_nterm; TIGR02675
1261557004793	Phage-related protein [Function unknown]; Region: COG5412
1261557004794	membrane protein P6; Region: PHA01399
1261557004795	Bacteriophage Gp15 protein; Region: Phage_Gp15; pfam06854
1261557004796	Minor capsid protein from bacteriophage; Region: Minor_capsid_3; pfam12691
1261557004797	Minor capsid protein; Region: Minor_capsid_2; pfam11114
1261557004798	Minor capsid protein; Region: Minor_capsid_1; pfam10665
1261557004799	Head-Tail Connector Proteins gp6 and gp15, and similar proteins; Region: gp6_gp15_like; cl12049
1261557004800	Phage minor structural protein GP20; Region: Phage_GP20; pfam06810
1261557004801	putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920
1261557004802	Phage minor capsid protein 2; Region: Phage_min_cap2; pfam06152
1261557004803	phage portal protein, putative, A118 family; Region: A118_put_portal; TIGR01542
1261557004804	Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133
1261557004805	Phage terminase large subunit; Region: Terminase_3; cl12054
1261557004806	Terminase-like family; Region: Terminase_6; pfam03237
1261557004807	Uncharacterized conserved protein [Function unknown]; Region: COG5484
1261557004808	Phage terminase small subunit; Region: Phage_terminase; pfam10668
1261557004809	phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637
1261557004810	Protein of unknown function (DUF1642); Region: DUF1642; pfam07852
1261557004811	YopX protein; Region: YopX; pfam09643
1261557004812	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
1261557004813	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
1261557004814	Int/Topo IB signature motif; other site
1261557004815	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
1261557004816	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
1261557004817	substrate interaction site [chemical binding]; other site
1261557004818	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u3; cd11540
1261557004819	putative metal binding site [ion binding]; other site
1261557004820	N-terminal phage replisome organiser (Phage_rep_org_N); Region: Phage_rep_org_N; cl09889
1261557004821	Protein of unknown function (DUF968); Region: DUF968; pfam06147
1261557004822	Protein of unknown function (DUF1351); Region: DUF1351; pfam07083
1261557004823	ERF superfamily; Region: ERF; pfam04404
1261557004824	Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669
1261557004825	ORF6C domain; Region: ORF6C; pfam10552
1261557004826	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
1261557004827	DNA binding residues [nucleotide binding]
1261557004828	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
1261557004829	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1261557004830	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1261557004831	non-specific DNA binding site [nucleotide binding]; other site
1261557004832	salt bridge; other site
1261557004833	sequence-specific DNA binding site [nucleotide binding]; other site
1261557004834	Predicted transcriptional regulator [Transcription]; Region: COG2932
1261557004835	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
1261557004836	Catalytic site [active]
1261557004837	Domain of unknown function (DUF4352); Region: DUF4352; pfam11611
1261557004838	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
1261557004839	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
1261557004840	Int/Topo IB signature motif; other site
1261557004841	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
1261557004842	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
1261557004843	active site
1261557004844	HIGH motif; other site
1261557004845	dimer interface [polypeptide binding]; other site
1261557004846	KMSKS motif; other site
1261557004847	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1261557004848	RNA binding surface [nucleotide binding]; other site
1261557004849	Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744
1261557004850	Transglycosylase; Region: Transgly; pfam00912
1261557004851	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
1261557004852	Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744
1261557004853	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
1261557004854	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1261557004855	Walker A/P-loop; other site
1261557004856	ATP binding site [chemical binding]; other site
1261557004857	Q-loop/lid; other site
1261557004858	ABC transporter signature motif; other site
1261557004859	Walker B; other site
1261557004860	D-loop; other site
1261557004861	H-loop/switch region; other site
1261557004862	catabolite control protein A; Region: ccpA; TIGR01481
1261557004863	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1261557004864	DNA binding site [nucleotide binding]
1261557004865	domain linker motif; other site
1261557004866	Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298
1261557004867	dimerization interface [polypeptide binding]; other site
1261557004868	effector binding site; other site
1261557004869	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
1261557004870	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
1261557004871	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
1261557004872	active site
1261557004873	YtxH-like protein; Region: YtxH; pfam12732
1261557004874	Bacterial protein of unknown function (DUF948); Region: DUF948; pfam06103
1261557004875	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
1261557004876	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
1261557004877	active site
1261557004878	tetramer interface; other site
1261557004879	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
1261557004880	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
1261557004881	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
1261557004882	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437
1261557004883	HPr kinase/phosphorylase; Provisional; Region: PRK05428
1261557004884	HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603
1261557004885	HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918
1261557004886	Hpr binding site; other site
1261557004887	active site
1261557004888	homohexamer subunit interaction site [polypeptide binding]; other site
1261557004889	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
1261557004890	GIY-YIG motif/motif A; other site
1261557004891	active site
1261557004892	catalytic site [active]
1261557004893	putative DNA binding site [nucleotide binding]; other site
1261557004894	metal binding site [ion binding]; metal-binding site
1261557004895	Membrane protein of unknown function; Region: DUF360; pfam04020
1261557004896	PspC domain; Region: PspC; pfam04024
1261557004897	Uncharacterized conserved protein [Function unknown]; Region: COG3595
1261557004898	Domain of unknown function (DUF4098); Region: DUF4098; pfam13345
1261557004899	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
1261557004900	PhoU domain; Region: PhoU; pfam01895
1261557004901	PhoU domain; Region: PhoU; pfam01895
1261557004902	phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14255
1261557004903	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
1261557004904	Walker A/P-loop; other site
1261557004905	ATP binding site [chemical binding]; other site
1261557004906	Q-loop/lid; other site
1261557004907	ABC transporter signature motif; other site
1261557004908	Walker B; other site
1261557004909	D-loop; other site
1261557004910	H-loop/switch region; other site
1261557004911	phosphate transporter ATP-binding protein; Provisional; Region: PRK14237
1261557004912	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
1261557004913	Walker A/P-loop; other site
1261557004914	ATP binding site [chemical binding]; other site
1261557004915	Q-loop/lid; other site
1261557004916	ABC transporter signature motif; other site
1261557004917	Walker B; other site
1261557004918	D-loop; other site
1261557004919	H-loop/switch region; other site
1261557004920	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
1261557004921	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1261557004922	dimer interface [polypeptide binding]; other site
1261557004923	conserved gate region; other site
1261557004924	putative PBP binding loops; other site
1261557004925	ABC-ATPase subunit interface; other site
1261557004926	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
1261557004927	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1261557004928	dimer interface [polypeptide binding]; other site
1261557004929	conserved gate region; other site
1261557004930	putative PBP binding loops; other site
1261557004931	ABC-ATPase subunit interface; other site
1261557004932	phosphate binding protein; Region: ptsS_2; TIGR02136
1261557004933	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
1261557004934	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
1261557004935	FtsX-like permease family; Region: FtsX; pfam02687
1261557004936	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
1261557004937	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1261557004938	Walker A/P-loop; other site
1261557004939	ATP binding site [chemical binding]; other site
1261557004940	Q-loop/lid; other site
1261557004941	ABC transporter signature motif; other site
1261557004942	Walker B; other site
1261557004943	D-loop; other site
1261557004944	H-loop/switch region; other site
1261557004945	peptide chain release factor 2; Provisional; Region: PRK06746
1261557004946	RNA polymerase II transcription mediator complex subunit 9; Region: Med9; pfam07544
1261557004947	This domain is found in peptide chain release factors; Region: PCRF; smart00937
1261557004948	RF-1 domain; Region: RF-1; pfam00472
1261557004949	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
1261557004950	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
1261557004951	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1261557004952	nucleotide binding region [chemical binding]; other site
1261557004953	ATP-binding site [chemical binding]; other site
1261557004954	SEC-C motif; Region: SEC-C; pfam02810
1261557004955	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
1261557004956	30S subunit binding site; other site
1261557004957	comF family protein; Region: comF; TIGR00201
1261557004958	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1261557004959	active site
1261557004960	Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098
1261557004961	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1261557004962	ATP binding site [chemical binding]; other site
1261557004963	putative Mg++ binding site [ion binding]; other site
1261557004964	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1261557004965	nucleotide binding region [chemical binding]; other site
1261557004966	ATP-binding site [chemical binding]; other site
1261557004967	Predicted ATPase [General function prediction only]; Region: COG3910
1261557004968	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1261557004969	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1261557004970	Walker A/P-loop; other site
1261557004971	Walker A/P-loop; other site
1261557004972	ATP binding site [chemical binding]; other site
1261557004973	ATP binding site [chemical binding]; other site
1261557004974	Q-loop/lid; other site
1261557004975	ABC transporter signature motif; other site
1261557004976	Walker B; other site
1261557004977	D-loop; other site
1261557004978	H-loop/switch region; other site
1261557004979	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
1261557004980	active site
1261557004981	P-loop; other site
1261557004982	phosphorylation site [posttranslational modification]
1261557004983	Uncharacterized conserved protein [Function unknown]; Region: COG1739
1261557004984	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
1261557004985	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
1261557004986	Protein of unknown function (DUF2829); Region: DUF2829; pfam11195
1261557004987	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK06550
1261557004988	classical (c) SDRs; Region: SDR_c; cd05233
1261557004989	NAD(P) binding site [chemical binding]; other site
1261557004990	active site
1261557004991	QueT transporter; Region: QueT; pfam06177
1261557004992	Tim44-like domain; Region: Tim44; cl09208
1261557004993	Protein of unknown function (DUF1648); Region: DUF1648; pfam07853
1261557004994	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
1261557004995	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
1261557004996	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
1261557004997	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
1261557004998	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
1261557004999	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
1261557005000	purine monophosphate binding site [chemical binding]; other site
1261557005001	dimer interface [polypeptide binding]; other site
1261557005002	putative catalytic residues [active]
1261557005003	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
1261557005004	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
1261557005005	Folate-dependent phosphoribosylglycinamide formyltransferase PurN [Nucleotide transport and metabolism]; Region: PurN; COG0299
1261557005006	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
1261557005007	active site
1261557005008	substrate binding site [chemical binding]; other site
1261557005009	cosubstrate binding site; other site
1261557005010	catalytic site [active]
1261557005011	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
1261557005012	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
1261557005013	dimerization interface [polypeptide binding]; other site
1261557005014	putative ATP binding site [chemical binding]; other site
1261557005015	amidophosphoribosyltransferase; Provisional; Region: PRK07272
1261557005016	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
1261557005017	active site
1261557005018	tetramer interface [polypeptide binding]; other site
1261557005019	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1261557005020	active site
1261557005021	phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213
1261557005022	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
1261557005023	dimerization interface [polypeptide binding]; other site
1261557005024	ATP binding site [chemical binding]; other site
1261557005025	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
1261557005026	dimerization interface [polypeptide binding]; other site
1261557005027	ATP binding site [chemical binding]; other site
1261557005028	phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619
1261557005029	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
1261557005030	putative active site [active]
1261557005031	catalytic triad [active]
1261557005032	Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700
1261557005033	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
1261557005034	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
1261557005035	ATP binding site [chemical binding]; other site
1261557005036	active site
1261557005037	substrate binding site [chemical binding]; other site
1261557005038	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
1261557005039	ATP-grasp domain; Region: ATP-grasp; pfam02222
1261557005040	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
1261557005041	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
1261557005042	A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual...; Region: Band_7_2; cd03402
1261557005043	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
1261557005044	putative substrate binding site [chemical binding]; other site
1261557005045	putative ATP binding site [chemical binding]; other site
1261557005046	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
1261557005047	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
1261557005048	peptide binding site [polypeptide binding]; other site
1261557005049	Cupin domain; Region: Cupin_2; pfam07883
1261557005050	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
1261557005051	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
1261557005052	homodimer interface [polypeptide binding]; other site
1261557005053	substrate-cofactor binding pocket; other site
1261557005054	catalytic residue [active]
1261557005055	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4876
1261557005056	Protein of unknown function (DUF998); Region: DUF998; pfam06197
1261557005057	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
1261557005058	Domain of unknown function DUF20; Region: UPF0118; pfam01594
1261557005059	Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532
1261557005060	Endo-alpha-N-acetylgalactosaminidase; Region: Glyco_hydro_101; pfam12905
1261557005061	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
1261557005062	active pocket/dimerization site; other site
1261557005063	active site
1261557005064	phosphorylation site [posttranslational modification]
1261557005065	PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613
1261557005066	PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609
1261557005067	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
1261557005068	active site
1261557005069	phosphorylation site [posttranslational modification]
1261557005070	Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874
1261557005071	Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301
1261557005072	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
1261557005073	putative substrate binding site [chemical binding]; other site
1261557005074	putative ATP binding site [chemical binding]; other site
1261557005075	tagatose 1,6-diphosphate aldolase; Reviewed; Region: PRK12399
1261557005076	putative sugar isomerase, AgaS family; Region: agaS_fam; TIGR02815
1261557005077	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
1261557005078	dimer interface [polypeptide binding]; other site
1261557005079	active site
1261557005080	AgaS-like protein. AgaS contains a SIS (Sugar ISomerase) domain which is found in many phosphosugar isomerases and phosphosugar binding proteins. AgaS is a putative isomerase in Escherichia coli. It is similar to the glucosamine-6-phosphate synthases; Region: SIS_AgaS_like; cd05010
1261557005081	putative active site [active]
1261557005082	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
1261557005083	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1261557005084	DNA-binding site [nucleotide binding]; DNA binding site
1261557005085	UTRA domain; Region: UTRA; pfam07702
1261557005086	A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194
1261557005087	Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501
1261557005088	Ligand binding site; other site
1261557005089	metal-binding site
1261557005090	A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194
1261557005091	Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501
1261557005092	Ligand binding site; other site
1261557005093	metal-binding site
1261557005094	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025
1261557005095	active site
1261557005096	active pocket/dimerization site; other site
1261557005097	phosphorylation site [posttranslational modification]
1261557005098	Transposase; Region: HTH_Tnp_1; pfam01527
1261557005099	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1261557005100	Integrase core domain; Region: rve; pfam00665
1261557005101	Integrase core domain; Region: rve_3; pfam13683
1261557005102	Cna protein B-type domain; Region: Cna_B; pfam05738
1261557005103	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
1261557005104	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
1261557005105	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
1261557005106	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
1261557005107	RimM N-terminal domain; Region: RimM; pfam01782
1261557005108	PRC-barrel domain; Region: PRC; pfam05239
1261557005109	manganese transport protein MntH; Reviewed; Region: PRK00701
1261557005110	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
1261557005111	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1261557005112	Mitomycin C resistance protein (MRD); Region: MRD; cd07235
1261557005113	dimer interface [polypeptide binding]; other site
1261557005114	ligand binding site [chemical binding]; other site
1261557005115	Uncharacterized conserved protein [Function unknown]; Region: COG0398
1261557005116	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
1261557005117	Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; pfam10110
1261557005118	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
1261557005119	Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579
1261557005120	putative active site [active]
1261557005121	catalytic site [active]
1261557005122	putative metal binding site [ion binding]; other site
1261557005123	Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432
1261557005124	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
1261557005125	(R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449
1261557005126	dimer interaction site [polypeptide binding]; other site
1261557005127	substrate-binding tunnel; other site
1261557005128	active site
1261557005129	catalytic site [active]
1261557005130	substrate binding site [chemical binding]; other site
1261557005131	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
1261557005132	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
1261557005133	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1261557005134	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1261557005135	Predicted membrane protein [Function unknown]; Region: COG4129
1261557005136	Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081
1261557005137	DUF939 C-terminal domain; Region: DUF939_C; pfam11728
1261557005138	Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081
1261557005139	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
1261557005140	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
1261557005141	nucleotide binding site [chemical binding]; other site
1261557005142	Haemolytic domain; Region: Haemolytic; pfam01809
1261557005143	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
1261557005144	G1 box; other site
1261557005145	GTP/Mg2+ binding site [chemical binding]; other site
1261557005146	Switch I region; other site
1261557005147	G2 box; other site
1261557005148	G3 box; other site
1261557005149	Switch II region; other site
1261557005150	G4 box; other site
1261557005151	G5 box; other site
1261557005152	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
1261557005153	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
1261557005154	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1261557005155	Walker A motif; other site
1261557005156	ATP binding site [chemical binding]; other site
1261557005157	Walker B motif; other site
1261557005158	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
1261557005159	Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282
1261557005160	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1261557005161	Coenzyme A binding pocket [chemical binding]; other site
1261557005162	C4-dicarboxylate transporter [Energy production and conversion]; Region: DcuC; cl17322
1261557005163	C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606
1261557005164	nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651
1261557005165	active site
1261557005166	tetramer interface [polypeptide binding]; other site
1261557005167	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1261557005168	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1261557005169	DNA binding site [nucleotide binding]
1261557005170	Ligand-binding domain of a transcription repressor, FucR, which functions as a molecular sensor of L-fucose availability; Region: PBP1_FucR_like; cd06276
1261557005171	putative dimerization interface [polypeptide binding]; other site
1261557005172	putative ligand binding site [chemical binding]; other site
1261557005173	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
1261557005174	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1261557005175	substrate binding site [chemical binding]; other site
1261557005176	dimer interface [polypeptide binding]; other site
1261557005177	ATP binding site [chemical binding]; other site
1261557005178	Mga helix-turn-helix domain; Region: Mga; pfam05043
1261557005179	5-bromo-4-chloroindolyl phosphate hydrolysis protein; Region: Halogen_Hydrol; pfam10112
1261557005180	Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580
1261557005181	amphipathic channel; other site
1261557005182	Asn-Pro-Ala signature motifs; other site
1261557005183	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578
1261557005184	glycerol kinase; Provisional; Region: glpK; PRK00047
1261557005185	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
1261557005186	N- and C-terminal domain interface [polypeptide binding]; other site
1261557005187	active site
1261557005188	MgATP binding site [chemical binding]; other site
1261557005189	catalytic site [active]
1261557005190	metal binding site [ion binding]; metal-binding site
1261557005191	glycerol binding site [chemical binding]; other site
1261557005192	homotetramer interface [polypeptide binding]; other site
1261557005193	homodimer interface [polypeptide binding]; other site
1261557005194	FBP binding site [chemical binding]; other site
1261557005195	protein IIAGlc interface [polypeptide binding]; other site
1261557005196	Mga helix-turn-helix domain; Region: Mga; pfam05043
1261557005197	CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385
1261557005198	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1261557005199	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1261557005200	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1261557005201	Transposase, Mutator family; Region: Transposase_mut; pfam00872
1261557005202	MULE transposase domain; Region: MULE; pfam10551
1261557005203	Transposase, Mutator family; Region: Transposase_mut; pfam00872
1261557005204	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1261557005205	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
1261557005206	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
1261557005207	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1261557005208	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
1261557005209	haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710
1261557005210	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
1261557005211	Predicted membrane protein [Function unknown]; Region: COG2364
1261557005212	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1261557005213	Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027
1261557005214	ligand binding site [chemical binding]; other site
1261557005215	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
1261557005216	putative switch regulator; other site
1261557005217	non-specific DNA interactions [nucleotide binding]; other site
1261557005218	DNA binding site [nucleotide binding]
1261557005219	sequence specific DNA binding site [nucleotide binding]; other site
1261557005220	putative cAMP binding site [chemical binding]; other site
1261557005221	Protein of unknown function (DUF3224); Region: DUF3224; pfam11528
1261557005222	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
1261557005223	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1261557005224	putative substrate translocation pore; other site
1261557005225	Sulfatase; Region: Sulfatase; pfam00884
1261557005226	Domain of unknown function (DU1801); Region: DUF1801; cl17490
1261557005227	Uncharacterized protein conserved in bacteria (DUF2200); Region: DUF2200; pfam09966
1261557005228	Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222
1261557005229	A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710
1261557005230	putative active site [active]
1261557005231	SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389
1261557005232	Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains [Cell envelope biogenesis, outer membrane]; Region: GlmS; COG0449
1261557005233	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
1261557005234	dimer interface [polypeptide binding]; other site
1261557005235	active site
1261557005236	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
1261557005237	dimer interface [polypeptide binding]; other site
1261557005238	active site
1261557005239	PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613
1261557005240	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715
1261557005241	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cl00021
1261557005242	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cl00021
1261557005243	active site
1261557005244	phosphorylation site [posttranslational modification]
1261557005245	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
1261557005246	active pocket/dimerization site; other site
1261557005247	active site
1261557005248	phosphorylation site [posttranslational modification]
1261557005249	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221
1261557005250	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1261557005251	Walker A motif; other site
1261557005252	ATP binding site [chemical binding]; other site
1261557005253	Walker B motif; other site
1261557005254	arginine finger; other site
1261557005255	Transcriptional antiterminator [Transcription]; Region: COG3933
1261557005256	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025
1261557005257	active pocket/dimerization site; other site
1261557005258	active site
1261557005259	phosphorylation site [posttranslational modification]
1261557005260	PRD domain; Region: PRD; pfam00874
1261557005261	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01096
1261557005262	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1261557005263	Zn2+ binding site [ion binding]; other site
1261557005264	Mg2+ binding site [ion binding]; other site
1261557005265	TIR domain; Region: TIR_2; pfam13676
1261557005266	enolase; Provisional; Region: eno; PRK00077
1261557005267	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
1261557005268	dimer interface [polypeptide binding]; other site
1261557005269	metal binding site [ion binding]; metal-binding site
1261557005270	substrate binding pocket [chemical binding]; other site
1261557005271	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
1261557005272	triosephosphate isomerase; Provisional; Region: PRK14565
1261557005273	substrate binding site [chemical binding]; other site
1261557005274	dimer interface [polypeptide binding]; other site
1261557005275	catalytic triad [active]
1261557005276	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
1261557005277	Phosphoglycerate kinase; Region: PGK; pfam00162
1261557005278	substrate binding site [chemical binding]; other site
1261557005279	hinge regions; other site
1261557005280	ADP binding site [chemical binding]; other site
1261557005281	catalytic site [active]
1261557005282	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
1261557005283	glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534
1261557005284	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
1261557005285	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
1261557005286	Predicted transcriptional regulator [Transcription]; Region: COG3388
1261557005287	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
1261557005288	Uncharacterized conserved protein [Function unknown]; Region: COG1284
1261557005289	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
1261557005290	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
1261557005291	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
1261557005292	Protein of unknown function (DUF436); Region: DUF436; pfam04260
1261557005293	ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; pfam07155
1261557005294	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
1261557005295	dimer interface [polypeptide binding]; other site
1261557005296	substrate binding site [chemical binding]; other site
1261557005297	ATP binding site [chemical binding]; other site
1261557005298	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
1261557005299	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
1261557005300	dimer interface [polypeptide binding]; other site
1261557005301	anticodon binding site; other site
1261557005302	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
1261557005303	homodimer interface [polypeptide binding]; other site
1261557005304	motif 1; other site
1261557005305	active site
1261557005306	motif 2; other site
1261557005307	GAD domain; Region: GAD; pfam02938
1261557005308	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
1261557005309	motif 3; other site
1261557005310	histidyl-tRNA synthetase; Region: hisS; TIGR00442
1261557005311	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
1261557005312	dimer interface [polypeptide binding]; other site
1261557005313	motif 1; other site
1261557005314	active site
1261557005315	motif 2; other site
1261557005316	motif 3; other site
1261557005317	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
1261557005318	anticodon binding site; other site
1261557005319	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
1261557005320	putative active site [active]
1261557005321	dimerization interface [polypeptide binding]; other site
1261557005322	putative tRNAtyr binding site [nucleotide binding]; other site
1261557005323	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
1261557005324	HD domain; Region: HD_4; pfam13328
1261557005325	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
1261557005326	synthetase active site [active]
1261557005327	NTP binding site [chemical binding]; other site
1261557005328	metal binding site [ion binding]; metal-binding site
1261557005329	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
1261557005330	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
1261557005331	RNA methyltransferase, RsmE family; Region: TIGR00046
1261557005332	RNA methyltransferase; Region: Methyltrans_RNA; pfam04452
1261557005333	Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325
1261557005334	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1261557005335	S-adenosylmethionine binding site [chemical binding]; other site
1261557005336	Protein of unknown function (DUF3013); Region: DUF3013; pfam11217
1261557005337	Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540
1261557005338	active site
1261557005339	DNA binding site [nucleotide binding]
1261557005340	recombination factor protein RarA; Reviewed; Region: PRK13342
1261557005341	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1261557005342	Walker A motif; other site
1261557005343	ATP binding site [chemical binding]; other site
1261557005344	Walker B motif; other site
1261557005345	arginine finger; other site
1261557005346	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
1261557005347	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1261557005348	Ligand Binding Site [chemical binding]; other site
1261557005349	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
1261557005350	propionate/acetate kinase; Provisional; Region: PRK12379
1261557005351	Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827
1261557005352	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1261557005353	S-adenosylmethionine binding site [chemical binding]; other site
1261557005354	Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940
1261557005355	Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537
1261557005356	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
1261557005357	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
1261557005358	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
1261557005359	Walker A motif; other site
1261557005360	ATP binding site [chemical binding]; other site
1261557005361	Walker B motif; other site
1261557005362	amino acid transporter; Region: 2A0306; TIGR00909
1261557005363	Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316
1261557005364	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455
1261557005365	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1261557005366	FeS/SAM binding site; other site
1261557005367	FtsX-like permease family; Region: FtsX; pfam02687
1261557005368	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1261557005369	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1261557005370	Walker A/P-loop; other site
1261557005371	ATP binding site [chemical binding]; other site
1261557005372	Q-loop/lid; other site
1261557005373	ABC transporter signature motif; other site
1261557005374	Walker B; other site
1261557005375	D-loop; other site
1261557005376	H-loop/switch region; other site
1261557005377	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
1261557005378	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1261557005379	DNA-binding site [nucleotide binding]; DNA binding site
1261557005380	UTRA domain; Region: UTRA; pfam07702
1261557005381	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
1261557005382	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
1261557005383	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
1261557005384	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
1261557005385	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
1261557005386	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1261557005387	1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080
1261557005388	UbiA prenyltransferase family; Region: UbiA; pfam01040
1261557005389	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
1261557005390	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
1261557005391	substrate binding pocket [chemical binding]; other site
1261557005392	chain length determination region; other site
1261557005393	substrate-Mg2+ binding site; other site
1261557005394	catalytic residues [active]
1261557005395	aspartate-rich region 1; other site
1261557005396	active site lid residues [active]
1261557005397	aspartate-rich region 2; other site
1261557005398	ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987
1261557005399	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1261557005400	ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247
1261557005401	Walker A/P-loop; other site
1261557005402	ATP binding site [chemical binding]; other site
1261557005403	Q-loop/lid; other site
1261557005404	ABC transporter signature motif; other site
1261557005405	Walker B; other site
1261557005406	D-loop; other site
1261557005407	H-loop/switch region; other site
1261557005408	thiol reductant ABC exporter, CydD subunit; Region: CydD; TIGR02857
1261557005409	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1261557005410	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1261557005411	Walker A/P-loop; other site
1261557005412	ATP binding site [chemical binding]; other site
1261557005413	Q-loop/lid; other site
1261557005414	ABC transporter signature motif; other site
1261557005415	Walker B; other site
1261557005416	D-loop; other site
1261557005417	H-loop/switch region; other site
1261557005418	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
1261557005419	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
1261557005420	cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097
1261557005421	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
1261557005422	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1261557005423	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1261557005424	Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871
1261557005425	DNA topoisomerase III; Provisional; Region: PRK07726
1261557005426	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
1261557005427	active site
1261557005428	putative interdomain interaction site [polypeptide binding]; other site
1261557005429	putative metal-binding site [ion binding]; other site
1261557005430	putative nucleotide binding site [chemical binding]; other site
1261557005431	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
1261557005432	domain I; other site
1261557005433	DNA binding groove [nucleotide binding]
1261557005434	phosphate binding site [ion binding]; other site
1261557005435	domain II; other site
1261557005436	domain III; other site
1261557005437	nucleotide binding site [chemical binding]; other site
1261557005438	catalytic site [active]
1261557005439	domain IV; other site
1261557005440	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
1261557005441	Protein of unknown function (DUF1033); Region: DUF1033; pfam06279
1261557005442	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1261557005443	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1261557005444	WHG domain; Region: WHG; pfam13305
1261557005445	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
1261557005446	substrate binding site [chemical binding]; other site
1261557005447	drug efflux system protein MdtG; Provisional; Region: PRK09874
1261557005448	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1261557005449	putative substrate translocation pore; other site
1261557005450	tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054
1261557005451	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
1261557005452	Putative amino acid metabolism; Region: DUF1831; pfam08866
1261557005453	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
1261557005454	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
1261557005455	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1261557005456	catalytic residue [active]
1261557005457	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02458
1261557005458	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
1261557005459	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1261557005460	active site
1261557005461	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
1261557005462	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
1261557005463	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
1261557005464	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1261557005465	ABC-ATPase subunit  interface; other site
1261557005466	dimer interface [polypeptide binding]; other site
1261557005467	putative PBP binding regions; other site
1261557005468	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
1261557005469	Metal binding protein PsaA.  These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137
1261557005470	metal binding site [ion binding]; metal-binding site
1261557005471	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
1261557005472	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1261557005473	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1261557005474	ABC transporter; Region: ABC_tran_2; pfam12848
1261557005475	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1261557005476	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
1261557005477	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_subfamily5; cd08019
1261557005478	metal binding site [ion binding]; metal-binding site
1261557005479	putative dimer interface [polypeptide binding]; other site
1261557005480	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
1261557005481	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
1261557005482	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1261557005483	dimer interface [polypeptide binding]; other site
1261557005484	conserved gate region; other site
1261557005485	ABC-ATPase subunit interface; other site
1261557005486	DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153
1261557005487	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
1261557005488	Walker A/P-loop; other site
1261557005489	ATP binding site [chemical binding]; other site
1261557005490	Q-loop/lid; other site
1261557005491	ABC transporter signature motif; other site
1261557005492	Walker B; other site
1261557005493	D-loop; other site
1261557005494	H-loop/switch region; other site
1261557005495	NIL domain; Region: NIL; pfam09383
1261557005496	Glucosyl transferase GtrII; Region: Glucos_trans_II; pfam14264
1261557005497	FemAB family; Region: FemAB; pfam02388
1261557005498	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
1261557005499	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
1261557005500	glutaminase active site [active]
1261557005501	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
1261557005502	dimer interface [polypeptide binding]; other site
1261557005503	active site
1261557005504	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
1261557005505	dimer interface [polypeptide binding]; other site
1261557005506	active site
1261557005507	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
1261557005508	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
1261557005509	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
1261557005510	Walker A/P-loop; other site
1261557005511	ATP binding site [chemical binding]; other site
1261557005512	Q-loop/lid; other site
1261557005513	ABC transporter signature motif; other site
1261557005514	Walker B; other site
1261557005515	D-loop; other site
1261557005516	H-loop/switch region; other site
1261557005517	ATP-binding cassette cobalt transporter; Region: DUF3744; pfam12558
1261557005518	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
1261557005519	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
1261557005520	Walker A/P-loop; other site
1261557005521	ATP binding site [chemical binding]; other site
1261557005522	Q-loop/lid; other site
1261557005523	ABC transporter signature motif; other site
1261557005524	Walker B; other site
1261557005525	D-loop; other site
1261557005526	H-loop/switch region; other site
1261557005527	hypothetical protein; Provisional; Region: PRK13661
1261557005528	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316
1261557005529	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
1261557005530	active site
1261557005531	substrate binding site [chemical binding]; other site
1261557005532	metal binding site [ion binding]; metal-binding site
1261557005533	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856
1261557005534	YbbR-like protein; Region: YbbR; pfam07949
1261557005535	Uncharacterized conserved protein [Function unknown]; Region: COG1624
1261557005536	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
1261557005537	pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176
1261557005538	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
1261557005539	dimer interface [polypeptide binding]; other site
1261557005540	PYR/PP interface [polypeptide binding]; other site
1261557005541	TPP binding site [chemical binding]; other site
1261557005542	substrate binding site [chemical binding]; other site
1261557005543	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
1261557005544	Domain of unknown function; Region: EKR; smart00890
1261557005545	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
1261557005546	Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377
1261557005547	TPP-binding site [chemical binding]; other site
1261557005548	dimer interface [polypeptide binding]; other site
1261557005549	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
1261557005550	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
1261557005551	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
1261557005552	Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105
1261557005553	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
1261557005554	DNA binding residues [nucleotide binding]
1261557005555	putative dimer interface [polypeptide binding]; other site
1261557005556	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
1261557005557	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
1261557005558	HflX GTPase family; Region: HflX; cd01878
1261557005559	G1 box; other site
1261557005560	GTP/Mg2+ binding site [chemical binding]; other site
1261557005561	Switch I region; other site
1261557005562	G2 box; other site
1261557005563	G3 box; other site
1261557005564	Switch II region; other site
1261557005565	G4 box; other site
1261557005566	G5 box; other site
1261557005567	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
1261557005568	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
1261557005569	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
1261557005570	Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563
1261557005571	active site
1261557005572	catalytic site [active]
1261557005573	metal binding site [ion binding]; metal-binding site
1261557005574	dimer interface [polypeptide binding]; other site
1261557005575	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
1261557005576	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
1261557005577	Ligand binding site; other site
1261557005578	Putative Catalytic site; other site
1261557005579	DXD motif; other site
1261557005580	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1261557005581	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1261557005582	NAD(P) binding site [chemical binding]; other site
1261557005583	active site
1261557005584	O-Antigen ligase; Region: Wzy_C; pfam04932
1261557005585	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1261557005586	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1261557005587	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
1261557005588	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
1261557005589	active site
1261557005590	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1261557005591	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
1261557005592	NAD(P) binding site [chemical binding]; other site
1261557005593	active site
1261557005594	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
1261557005595	substrate binding site; other site
1261557005596	dimer interface; other site
1261557005597	AtlA is an autolysin found in Gram-positive lactic acid bacteria that degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. This family includes the AtlA and Aml...; Region: GH25_AtlA-like; cd06522
1261557005598	Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183
1261557005599	active site
1261557005600	LicD family; Region: LicD; cl01378
1261557005601	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
1261557005602	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
1261557005603	active site
1261557005604	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
1261557005605	Bacterial sugar transferase; Region: Bac_transf; pfam02397
1261557005606	O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425
1261557005607	Myxococcus xanthus RfbC like proteins are required for O-antigen biosynthesis; Region: GT2_RfbC_Mx_like; cd04184
1261557005608	Probable Catalytic site; other site
1261557005609	metal-binding site
1261557005610	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
1261557005611	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
1261557005612	Probable Catalytic site; other site
1261557005613	metal-binding site
1261557005614	Methyltransferase domain; Region: Methyltransf_23; pfam13489
1261557005615	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1261557005616	S-adenosylmethionine binding site [chemical binding]; other site
1261557005617	Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215
1261557005618	Myxococcus xanthus RfbC like proteins are required for O-antigen biosynthesis; Region: GT2_RfbC_Mx_like; cd04184
1261557005619	Probable Catalytic site; other site
1261557005620	metal-binding site
1261557005621	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1261557005622	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
1261557005623	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
1261557005624	Walker A/P-loop; other site
1261557005625	ATP binding site [chemical binding]; other site
1261557005626	Q-loop/lid; other site
1261557005627	ABC transporter signature motif; other site
1261557005628	Walker B; other site
1261557005629	D-loop; other site
1261557005630	H-loop/switch region; other site
1261557005631	C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147
1261557005632	putative carbohydrate binding site [chemical binding]; other site
1261557005633	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
1261557005634	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
1261557005635	Uncharacterized conserved protein (DUF2304); Region: DUF2304; cl01034
1261557005636	dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726
1261557005637	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
1261557005638	Ligand binding site; other site
1261557005639	Putative Catalytic site; other site
1261557005640	DXD motif; other site
1261557005641	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
1261557005642	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
1261557005643	NADP binding site [chemical binding]; other site
1261557005644	active site
1261557005645	putative substrate binding site [chemical binding]; other site
1261557005646	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
1261557005647	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
1261557005648	NAD binding site [chemical binding]; other site
1261557005649	substrate binding site [chemical binding]; other site
1261557005650	homodimer interface [polypeptide binding]; other site
1261557005651	active site
1261557005652	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908
1261557005653	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
1261557005654	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
1261557005655	substrate binding site; other site
1261557005656	tetramer interface; other site
1261557005657	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1261557005658	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196
1261557005659	Probable Catalytic site; other site
1261557005660	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
1261557005661	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1261557005662	active site
1261557005663	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
1261557005664	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
1261557005665	Probable Catalytic site; other site
1261557005666	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1261557005667	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
1261557005668	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
1261557005669	Mg++ binding site [ion binding]; other site
1261557005670	putative catalytic motif [active]
1261557005671	substrate binding site [chemical binding]; other site
1261557005672	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
1261557005673	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
1261557005674	active site
1261557005675	flavodoxin; Validated; Region: PRK07308
1261557005676	TspO/MBR family; Region: TspO_MBR; pfam03073
1261557005677	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1261557005678	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1261557005679	WHG domain; Region: WHG; pfam13305
1261557005680	Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073
1261557005681	Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309
1261557005682	Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225
1261557005683	pentamer interface [polypeptide binding]; other site
1261557005684	dodecaamer interface [polypeptide binding]; other site
1261557005685	Transposase, Mutator family; Region: Transposase_mut; pfam00872
1261557005686	MULE transposase domain; Region: MULE; pfam10551
1261557005687	Glucosyl transferase GtrII; Region: Glucos_trans_II; pfam14264
1261557005688	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
1261557005689	Peptidase family M23; Region: Peptidase_M23; pfam01551
1261557005690	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832
1261557005691	Cpl-1 lysin (also known as Cpl-9 lysozyme / muramidase) is a bacterial cell wall endolysin encoded by the pneumococcal bacteriophage Cp-1, which cleaves the glycosidic N-acetylmuramoyl-(beta1,4)-N-acetylglucosamine bonds of the pneumococcal glycan chain; Region: GH25_Cpl1-like; cd06415
1261557005692	Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183
1261557005693	active site
1261557005694	LysM domain/BON superfamily protein; Provisional; Region: PRK11198
1261557005695	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1261557005696	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1261557005697	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
1261557005698	Prophage endopeptidase tail; Region: Prophage_tail; cl12123
1261557005699	Phage tail protein; Region: Sipho_tail; pfam05709
1261557005700	tape measure domain; Region: tape_meas_nterm; TIGR02675
1261557005701	Phage protein; Region: DUF3647; pfam12363
1261557005702	Phage major tail protein 2; Region: Phage_tail_2; cl11463
1261557005703	Protein of unknown function (DUF3168); Region: DUF3168; pfam11367
1261557005704	Bacteriophage protein of unknown function (DUF646); Region: DUF646; cl12124
1261557005705	Phage gp6-like head-tail connector protein; Region: Phage_connect_1; pfam05135
1261557005706	Phage major capsid protein E; Region: Phage_cap_E; pfam03864
1261557005707	Domain of unknown function (DUF4355); Region: DUF4355; pfam14265
1261557005708	PGDYG protein; Region: PGDYG; pfam14083
1261557005709	Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072
1261557005710	Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133
1261557005711	phage portal protein, SPP1 family; Region: portal_SPP1; TIGR01538
1261557005712	DEAD-like helicases superfamily; Region: DEXDc; smart00487
1261557005713	Uncharacterized conserved protein [Function unknown]; Region: COG5484
1261557005714	Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056
1261557005715	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
1261557005716	ParB-like nuclease domain; Region: ParBc; pfam02195
1261557005717	ribonuclease Y; Region: RNase_Y; TIGR03319
1261557005718	phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637
1261557005719	Protein of unknown function (DUF1642); Region: DUF1642; pfam07852
1261557005720	Domain of Unknown Function with PDB structure (DUF3850); Region: DUF3850; pfam12961
1261557005721	YopX protein; Region: YopX; pfam09643
1261557005722	Methyltransferase domain; Region: Methyltransf_25; pfam13649
1261557005723	YsaB-like lipoprotein; Region: YsaB; pfam13983
1261557005724	N-terminal phage replisome organiser (Phage_rep_org_N); Region: Phage_rep_org_N; pfam09681
1261557005725	Protein of unknown function (DUF968); Region: DUF968; pfam06147
1261557005726	Protein of unknown function (DUF1351); Region: DUF1351; pfam07083
1261557005727	ERF superfamily; Region: ERF; pfam04404
1261557005728	AntA/AntB antirepressor; Region: AntA; cl01430
1261557005729	Phage antirepressor protein KilAC domain; Region: ANT; pfam03374
1261557005730	Protein of unknown function (DUF739); Region: DUF739; pfam05339
1261557005731	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1261557005732	non-specific DNA binding site [nucleotide binding]; other site
1261557005733	salt bridge; other site
1261557005734	sequence-specific DNA binding site [nucleotide binding]; other site
1261557005735	Domain of unknown function (DUF955); Region: DUF955; pfam06114
1261557005736	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1261557005737	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
1261557005738	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1261557005739	active site
1261557005740	DNA binding site [nucleotide binding]
1261557005741	Int/Topo IB signature motif; other site
1261557005742	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
1261557005743	nucleoside/Zn binding site; other site
1261557005744	dimer interface [polypeptide binding]; other site
1261557005745	catalytic motif [active]
1261557005746	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
1261557005747	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
1261557005748	Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298
1261557005749	Protein of unknown function (DUF1093); Region: DUF1093; cl02185
1261557005750	37-kD nucleoid-associated bacterial protein; Region: NA37; cl15473
1261557005751	PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992
1261557005752	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1261557005753	active site turn [active]
1261557005754	phosphorylation site [posttranslational modification]
1261557005755	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
1261557005756	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352
1261557005757	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1261557005758	putative metal binding site [ion binding]; other site
1261557005759	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899
1261557005760	putative hydrophobic ligand binding site [chemical binding]; other site
1261557005761	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
1261557005762	Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537
1261557005763	Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971
1261557005764	Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753
1261557005765	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1261557005766	active site
1261557005767	phosphorylation site [posttranslational modification]
1261557005768	intermolecular recognition site; other site
1261557005769	dimerization interface [polypeptide binding]; other site
1261557005770	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1261557005771	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1261557005772	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
1261557005773	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
1261557005774	Histidine kinase; Region: His_kinase; pfam06580
1261557005775	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1261557005776	ATP binding site [chemical binding]; other site
1261557005777	Mg2+ binding site [ion binding]; other site
1261557005778	G-X-G motif; other site
1261557005779	Protein of unknown function, DUF624; Region: DUF624; cl02369
1261557005780	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1261557005781	Domain of unknown function (DUF3502); Region: DUF3502; pfam12010
1261557005782	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1261557005783	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1261557005784	dimer interface [polypeptide binding]; other site
1261557005785	ABC-ATPase subunit interface; other site
1261557005786	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
1261557005787	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1261557005788	dimer interface [polypeptide binding]; other site
1261557005789	conserved gate region; other site
1261557005790	putative PBP binding loops; other site
1261557005791	ABC-ATPase subunit interface; other site
1261557005792	CAAX protease self-immunity; Region: Abi; pfam02517
1261557005793	fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226
1261557005794	conserved repeat domain; Region: B_ant_repeat; TIGR01451
1261557005795	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
1261557005796	Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592
1261557005797	DNA binding residues [nucleotide binding]
1261557005798	dimer interface [polypeptide binding]; other site
1261557005799	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1261557005800	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1261557005801	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1261557005802	Walker A/P-loop; other site
1261557005803	ATP binding site [chemical binding]; other site
1261557005804	Q-loop/lid; other site
1261557005805	ABC transporter signature motif; other site
1261557005806	Walker B; other site
1261557005807	D-loop; other site
1261557005808	H-loop/switch region; other site
1261557005809	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1261557005810	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1261557005811	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
1261557005812	Walker A/P-loop; other site
1261557005813	ATP binding site [chemical binding]; other site
1261557005814	Q-loop/lid; other site
1261557005815	ABC transporter signature motif; other site
1261557005816	Walker B; other site
1261557005817	D-loop; other site
1261557005818	H-loop/switch region; other site
1261557005819	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
1261557005820	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
1261557005821	active site
1261557005822	HIGH motif; other site
1261557005823	dimer interface [polypeptide binding]; other site
1261557005824	KMSKS motif; other site
1261557005825	GTP-binding protein LepA; Provisional; Region: PRK05433
1261557005826	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
1261557005827	G1 box; other site
1261557005828	putative GEF interaction site [polypeptide binding]; other site
1261557005829	GTP/Mg2+ binding site [chemical binding]; other site
1261557005830	Switch I region; other site
1261557005831	G2 box; other site
1261557005832	G3 box; other site
1261557005833	Switch II region; other site
1261557005834	G4 box; other site
1261557005835	G5 box; other site
1261557005836	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
1261557005837	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
1261557005838	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
1261557005839	Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527
1261557005840	Sterol carrier protein domain; Region: SCP2_2; pfam13530
1261557005841	Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014
1261557005842	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
1261557005843	Clp amino terminal domain; Region: Clp_N; pfam02861
1261557005844	Clp amino terminal domain; Region: Clp_N; pfam02861
1261557005845	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1261557005846	Walker A motif; other site
1261557005847	ATP binding site [chemical binding]; other site
1261557005848	Walker B motif; other site
1261557005849	arginine finger; other site
1261557005850	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1261557005851	Walker A motif; other site
1261557005852	ATP binding site [chemical binding]; other site
1261557005853	Walker B motif; other site
1261557005854	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
1261557005855	DoxX; Region: DoxX; pfam07681
1261557005856	adenylosuccinate lyase; Provisional; Region: PRK07492
1261557005857	Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360
1261557005858	tetramer interface [polypeptide binding]; other site
1261557005859	active site
1261557005860	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
1261557005861	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
1261557005862	NAD binding site [chemical binding]; other site
1261557005863	ATP-grasp domain; Region: ATP-grasp; pfam02222
1261557005864	xanthine permease; Region: pbuX; TIGR03173
1261557005865	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1261557005866	active site
1261557005867	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
1261557005868	Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705
1261557005869	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1261557005870	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1261557005871	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1261557005872	asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932
1261557005873	AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs.  This domain is a...; Region: AsnRS_cyto_like_N; cd04323
1261557005874	putative dimer interface [polypeptide binding]; other site
1261557005875	putative anticodon binding site; other site
1261557005876	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776
1261557005877	homodimer interface [polypeptide binding]; other site
1261557005878	motif 1; other site
1261557005879	motif 2; other site
1261557005880	active site
1261557005881	motif 3; other site
1261557005882	aspartate aminotransferase; Provisional; Region: PRK05764
1261557005883	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1261557005884	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1261557005885	homodimer interface [polypeptide binding]; other site
1261557005886	catalytic residue [active]
1261557005887	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353
1261557005888	DnaQ family exonuclease/DinG family helicase, putative; Region: dinG_rel; TIGR01407
1261557005889	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
1261557005890	active site
1261557005891	catalytic site [active]
1261557005892	substrate binding site [chemical binding]; other site
1261557005893	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
1261557005894	ATP binding site [chemical binding]; other site
1261557005895	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
1261557005896	Amino acid permease; Region: AA_permease_2; pfam13520
1261557005897	DNA polymerase III PolC; Validated; Region: polC; PRK00448
1261557005898	DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490
1261557005899	polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484
1261557005900	generic binding surface II; other site
1261557005901	generic binding surface I; other site
1261557005902	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
1261557005903	active site
1261557005904	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
1261557005905	active site
1261557005906	catalytic site [active]
1261557005907	substrate binding site [chemical binding]; other site
1261557005908	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435
1261557005909	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
1261557005910	prolyl-tRNA synthetase; Provisional; Region: PRK09194
1261557005911	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
1261557005912	dimer interface [polypeptide binding]; other site
1261557005913	motif 1; other site
1261557005914	active site
1261557005915	motif 2; other site
1261557005916	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
1261557005917	putative deacylase active site [active]
1261557005918	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
1261557005919	active site
1261557005920	motif 3; other site
1261557005921	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
1261557005922	anticodon binding site; other site
1261557005923	RIP metalloprotease RseP; Region: TIGR00054
1261557005924	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
1261557005925	active site
1261557005926	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
1261557005927	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
1261557005928	protein binding site [polypeptide binding]; other site
1261557005929	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
1261557005930	putative substrate binding region [chemical binding]; other site
1261557005931	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
1261557005932	FeS assembly protein SufB; Region: sufB; TIGR01980
1261557005933	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
1261557005934	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
1261557005935	trimerization site [polypeptide binding]; other site
1261557005936	active site
1261557005937	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
1261557005938	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
1261557005939	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1261557005940	catalytic residue [active]
1261557005941	Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719
1261557005942	FeS assembly protein SufD; Region: sufD; TIGR01981
1261557005943	Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396
1261557005944	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
1261557005945	Walker A/P-loop; other site
1261557005946	ATP binding site [chemical binding]; other site
1261557005947	Q-loop/lid; other site
1261557005948	ABC transporter signature motif; other site
1261557005949	Walker B; other site
1261557005950	D-loop; other site
1261557005951	H-loop/switch region; other site
1261557005952	ribosome recycling factor; Reviewed; Region: frr; PRK00083
1261557005953	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
1261557005954	hinge region; other site
1261557005955	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
1261557005956	putative nucleotide binding site [chemical binding]; other site
1261557005957	uridine monophosphate binding site [chemical binding]; other site
1261557005958	homohexameric interface [polypeptide binding]; other site
1261557005959	elongation factor Ts; Provisional; Region: tsf; PRK09377
1261557005960	UBA/TS-N domain; Region: UBA; pfam00627
1261557005961	Elongation factor TS; Region: EF_TS; pfam00889
1261557005962	Elongation factor TS; Region: EF_TS; pfam00889
1261557005963	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
1261557005964	rRNA interaction site [nucleotide binding]; other site
1261557005965	S8 interaction site; other site
1261557005966	putative laminin-1 binding site; other site
1261557005967	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
1261557005968	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1261557005969	Coenzyme A binding pocket [chemical binding]; other site
1261557005970	rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186
1261557005971	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
1261557005972	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
1261557005973	Acylphosphatases [Energy production and conversion]; Region: AcyP; COG1254
1261557005974	OxaA-like protein precursor; Provisional; Region: PRK02463
1261557005975	60Kd inner membrane protein; Region: 60KD_IMP; cl00489
1261557005976	hypothetical protein; Provisional; Region: PRK07758
1261557005977	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
1261557005978	DALR anticodon binding domain; Region: DALR_1; pfam05746
1261557005979	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
1261557005980	dimer interface [polypeptide binding]; other site
1261557005981	motif 1; other site
1261557005982	active site
1261557005983	motif 2; other site
1261557005984	motif 3; other site
1261557005985	Recombination protein O N terminal; Region: RecO_N; pfam11967
1261557005986	DNA repair protein RecO; Region: reco; TIGR00613
1261557005987	Recombination protein O C terminal; Region: RecO_C; pfam02565
1261557005988	GTPase Era; Reviewed; Region: era; PRK00089
1261557005989	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
1261557005990	G1 box; other site
1261557005991	GTP/Mg2+ binding site [chemical binding]; other site
1261557005992	Switch I region; other site
1261557005993	G2 box; other site
1261557005994	Switch II region; other site
1261557005995	G3 box; other site
1261557005996	G4 box; other site
1261557005997	G5 box; other site
1261557005998	KH domain; Region: KH_2; pfam07650
1261557005999	Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818
1261557006000	metal-binding heat shock protein; Provisional; Region: PRK00016
1261557006001	Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480
1261557006002	7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698
1261557006003	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1261557006004	Zn2+ binding site [ion binding]; other site
1261557006005	Mg2+ binding site [ion binding]; other site
1261557006006	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
1261557006007	PhoH-like protein; Region: PhoH; pfam02562
1261557006008	Yqey-like protein; Region: YqeY; pfam09424
1261557006009	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
1261557006010	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
1261557006011	metal binding site 2 [ion binding]; metal-binding site
1261557006012	putative DNA binding helix; other site
1261557006013	metal binding site 1 [ion binding]; metal-binding site
1261557006014	dimer interface [polypeptide binding]; other site
1261557006015	structural Zn2+ binding site [ion binding]; other site
1261557006016	Kinase/pyrophosphorylase; Region: Kinase-PPPase; pfam03618
1261557006017	homoserine kinase; Provisional; Region: PRK01212
1261557006018	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
1261557006019	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
1261557006020	threonine synthase; Reviewed; Region: PRK06721
1261557006021	Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of  threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563
1261557006022	homodimer interface [polypeptide binding]; other site
1261557006023	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1261557006024	catalytic residue [active]
1261557006025	homoserine dehydrogenase; Provisional; Region: PRK06349
1261557006026	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
1261557006027	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
1261557006028	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
1261557006029	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1261557006030	dimerization interface [polypeptide binding]; other site
1261557006031	putative DNA binding site [nucleotide binding]; other site
1261557006032	putative Zn2+ binding site [ion binding]; other site
1261557006033	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
1261557006034	Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345
1261557006035	phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150
1261557006036	This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799
1261557006037	active site
1261557006038	substrate binding site [chemical binding]; other site
1261557006039	metal binding site [ion binding]; metal-binding site
1261557006040	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
1261557006041	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1261557006042	DNA-binding site [nucleotide binding]; DNA binding site
1261557006043	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1261557006044	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1261557006045	homodimer interface [polypeptide binding]; other site
1261557006046	catalytic residue [active]
1261557006047	Predicted transcriptional regulators [Transcription]; Region: COG1695
1261557006048	Transcriptional regulator PadR-like family; Region: PadR; cl17335
1261557006049	guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458
1261557006050	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
1261557006051	active site
1261557006052	xanthine permease; Region: pbuX; TIGR03173
1261557006053	Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303
1261557006054	guanine deaminase; Region: guan_deamin; TIGR02967
1261557006055	active site
1261557006056	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1261557006057	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1261557006058	catalytic core [active]
1261557006059	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1261557006060	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
1261557006061	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
1261557006062	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
1261557006063	putative active site [active]
1261557006064	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1261557006065	active site turn [active]
1261557006066	phosphorylation site [posttranslational modification]
1261557006067	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
1261557006068	Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378
1261557006069	N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441
1261557006070	N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007
1261557006071	putative active site [active]
1261557006072	Uncharacterized conserved protein [Function unknown]; Region: COG3589
1261557006073	Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913
1261557006074	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
1261557006075	HPr interaction site; other site
1261557006076	glycerol kinase (GK) interaction site [polypeptide binding]; other site
1261557006077	active site
1261557006078	phosphorylation site [posttranslational modification]
1261557006079	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
1261557006080	uncharacterized YdjC-like family proteins from bacteria; Region: YdjC_like_1; cd10805
1261557006081	putative active site [active]
1261557006082	YdjC motif; other site
1261557006083	Mg binding site [ion binding]; other site
1261557006084	putative homodimer interface [polypeptide binding]; other site
1261557006085	Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392
1261557006086	Phosphate transporter family; Region: PHO4; pfam01384
1261557006087	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
1261557006088	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
1261557006089	2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522
1261557006090	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
1261557006091	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
1261557006092	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574
1261557006093	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
1261557006094	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
1261557006095	Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658
1261557006096	Competence protein; Region: Competence; pfam03772
1261557006097	Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333
1261557006098	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1261557006099	Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286
1261557006100	catalytic motif [active]
1261557006101	Zn binding site [ion binding]; other site
1261557006102	SLBB domain; Region: SLBB; pfam10531
1261557006103	comEA protein; Region: comE; TIGR01259
1261557006104	RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966
1261557006105	Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480
1261557006106	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117
1261557006107	protein binding site [polypeptide binding]; other site
1261557006108	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
1261557006109	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
1261557006110	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
1261557006111	active site
1261557006112	(T/H)XGH motif; other site
1261557006113	Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602
1261557006114	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1261557006115	S-adenosylmethionine binding site [chemical binding]; other site
1261557006116	Uncharacterized protein conserved in bacteria (DUF2129); Region: DUF2129; pfam09902
1261557006117	Protein of unknown function (DUF964); Region: DUF964; pfam06133
1261557006118	pyruvate carboxylase; Reviewed; Region: PRK12999
1261557006119	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1261557006120	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
1261557006121	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
1261557006122	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
1261557006123	active site
1261557006124	catalytic residues [active]
1261557006125	metal binding site [ion binding]; metal-binding site
1261557006126	homodimer binding site [polypeptide binding]; other site
1261557006127	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
1261557006128	carboxyltransferase (CT) interaction site; other site
1261557006129	biotinylation site [posttranslational modification]; other site
1261557006130	Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772
1261557006131	hypothetical protein; Provisional; Region: PRK13666
1261557006132	ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389
1261557006133	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1261557006134	ATP binding site [chemical binding]; other site
1261557006135	putative Mg++ binding site [ion binding]; other site
1261557006136	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1261557006137	nucleotide binding region [chemical binding]; other site
1261557006138	ATP-binding site [chemical binding]; other site
1261557006139	This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956
1261557006140	HRDC domain; Region: HRDC; pfam00570
1261557006141	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
1261557006142	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
1261557006143	G1 box; other site
1261557006144	putative GEF interaction site [polypeptide binding]; other site
1261557006145	GTP/Mg2+ binding site [chemical binding]; other site
1261557006146	Switch I region; other site
1261557006147	G2 box; other site
1261557006148	G3 box; other site
1261557006149	Switch II region; other site
1261557006150	G4 box; other site
1261557006151	G5 box; other site
1261557006152	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
1261557006153	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
1261557006154	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
1261557006155	Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637
1261557006156	active site
1261557006157	hypothetical protein; Provisional; Region: PRK04387
1261557006158	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
1261557006159	ClC sycA-like chloride channel proteins. This ClC family presents in bacteria, where it facilitates acid resistance in acidic soil. Mutation of this gene (sycA) in Rhizobium tropici CIAT899 causes serious deficiencies in nodule development, nodulation...; Region: ClC_sycA_like; cd03682
1261557006160	putative Cl- selectivity filter; other site
1261557006161	putative pore gating glutamate residue; other site
1261557006162	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1261557006163	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1261557006164	non-specific DNA binding site [nucleotide binding]; other site
1261557006165	salt bridge; other site
1261557006166	sequence-specific DNA binding site [nucleotide binding]; other site
1261557006167	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1261557006168	Zn2+ binding site [ion binding]; other site
1261557006169	Mg2+ binding site [ion binding]; other site
1261557006170	arginyl-tRNA synthetase; Reviewed; Region: PRK12451
1261557006171	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
1261557006172	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
1261557006173	active site
1261557006174	HIGH motif; other site
1261557006175	KMSK motif region; other site
1261557006176	Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956
1261557006177	tRNA binding surface [nucleotide binding]; other site
1261557006178	anticodon binding site; other site
1261557006179	UGMP family protein; Validated; Region: PRK09604
1261557006180	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
1261557006181	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
1261557006182	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1261557006183	Coenzyme A binding pocket [chemical binding]; other site
1261557006184	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
1261557006185	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1261557006186	Coenzyme A binding pocket [chemical binding]; other site
1261557006187	Glycoprotease family; Region: Peptidase_M22; pfam00814
1261557006188	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
1261557006189	NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223
1261557006190	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
1261557006191	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
1261557006192	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1261557006193	Membrane protease subunit, stomatin/prohibitin family [Amino acid    transport and metabolism]; Region: COG4260
1261557006194	A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual...; Region: Band_7_5; cd03408
1261557006195	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
1261557006196	Uncharacterized protein family UPF0547; Region: UPF0547; pfam10571
1261557006197	Repair protein; Region: Repair_PSII; pfam04536
1261557006198	Short C-terminal domain; Region: SHOCT; pfam09851
1261557006199	Transposase IS200 like; Region: Y1_Tnp; pfam01797
1261557006200	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
1261557006201	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1261557006202	motif II; other site
1261557006203	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_IV; cd01994
1261557006204	Ligand Binding Site [chemical binding]; other site
1261557006205	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
1261557006206	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
1261557006207	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
1261557006208	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475
1261557006209	catalytic residue [active]
1261557006210	putative FPP diphosphate  binding site; other site
1261557006211	putative FPP binding hydrophobic cleft; other site
1261557006212	dimer interface [polypeptide binding]; other site
1261557006213	putative IPP diphosphate binding site; other site
1261557006214	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
1261557006215	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
1261557006216	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1261557006217	dimer interface [polypeptide binding]; other site
1261557006218	conserved gate region; other site
1261557006219	ABC-ATPase subunit interface; other site
1261557006220	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
1261557006221	DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153
1261557006222	Walker A/P-loop; other site
1261557006223	ATP binding site [chemical binding]; other site
1261557006224	Q-loop/lid; other site
1261557006225	ABC transporter signature motif; other site
1261557006226	Walker B; other site
1261557006227	D-loop; other site
1261557006228	H-loop/switch region; other site
1261557006229	This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930
1261557006230	Transposase IS200 like; Region: Y1_Tnp; pfam01797
1261557006231	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
1261557006232	lipoyl attachment site [posttranslational modification]; other site
1261557006233	Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036
1261557006234	ArsC family; Region: ArsC; pfam03960
1261557006235	putative ArsC-like catalytic residues; other site
1261557006236	putative TRX-like catalytic residues [active]
1261557006237	Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772
1261557006238	Mga helix-turn-helix domain; Region: Mga; pfam05043
1261557006239	Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523
1261557006240	Cna protein B-type domain; Region: Cna_B; pfam05738
1261557006241	Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523
1261557006242	Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523
1261557006243	Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523
1261557006244	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1261557006245	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1261557006246	non-specific DNA binding site [nucleotide binding]; other site
1261557006247	salt bridge; other site
1261557006248	sequence-specific DNA binding site [nucleotide binding]; other site
1261557006249	Cupin domain; Region: Cupin_2; pfam07883
1261557006250	Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296
1261557006251	Predicted membrane protein [Function unknown]; Region: COG4392
1261557006252	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1261557006253	active site
1261557006254	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
1261557006255	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
1261557006256	dimer interface [polypeptide binding]; other site
1261557006257	active site
1261557006258	glycine-pyridoxal phosphate binding site [chemical binding]; other site
1261557006259	folate binding site [chemical binding]; other site
1261557006260	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
1261557006261	Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481
1261557006262	protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534
1261557006263	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1261557006264	S-adenosylmethionine binding site [chemical binding]; other site
1261557006265	peptide chain release factor 1; Validated; Region: prfA; PRK00591
1261557006266	This domain is found in peptide chain release factors; Region: PCRF; smart00937
1261557006267	RF-1 domain; Region: RF-1; pfam00472
1261557006268	thymidine kinase; Provisional; Region: PRK04296
1261557006269	fumarate reductase flavoprotein subunit; Validated; Region: PRK06481
1261557006270	L-aspartate oxidase; Provisional; Region: PRK06175
1261557006271	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
1261557006272	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
1261557006273	pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176
1261557006274	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
1261557006275	dimer interface [polypeptide binding]; other site
1261557006276	PYR/PP interface [polypeptide binding]; other site
1261557006277	TPP binding site [chemical binding]; other site
1261557006278	substrate binding site [chemical binding]; other site
1261557006279	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
1261557006280	Domain of unknown function; Region: EKR; smart00890
1261557006281	4Fe-4S binding domain; Region: Fer4_6; pfam12837
1261557006282	4Fe-4S binding domain; Region: Fer4; pfam00037
1261557006283	Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377
1261557006284	TPP-binding site [chemical binding]; other site
1261557006285	dimer interface [polypeptide binding]; other site
1261557006286	putative oxidoreductase; Provisional; Region: PRK12831
1261557006287	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
1261557006288	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1261557006289	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1261557006290	ferredoxin-NADP(+) reductase subunit alpha; Reviewed; Region: PRK06222
1261557006291	FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)...; Region: DHOD_e_trans_like1; cd06219
1261557006292	FAD binding pocket [chemical binding]; other site
1261557006293	FAD binding motif [chemical binding]; other site
1261557006294	phosphate binding motif [ion binding]; other site
1261557006295	beta-alpha-beta structure motif; other site
1261557006296	NAD binding pocket [chemical binding]; other site
1261557006297	Iron coordination center [ion binding]; other site
1261557006298	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
1261557006299	selenium-dependent molybdenum hydroxylase system protein, YqeB family; Region: matur_yqeB; TIGR03309
1261557006300	probable selenium-dependent hydroxylase accessory protein YqeC; Region: TIGR03172
1261557006301	Protein of unknown function (DUF3343); Region: DUF3343; pfam11823
1261557006302	selenium metabolism protein YedF; Region: selenium_YedF; TIGR03527
1261557006303	SirA_like_N, a protein of unknown function with an N-terminal SirA-like domain.  The SirA, YedF, YeeD protein family is present in bacteria as well as archaea. SirA (also known as UvrY,  and YhhP) belongs to a family of a two-component response...; Region: SirA_like_N; cd03421
1261557006304	CPxP  motif; other site
1261557006305	DsrE/DsrF-like family; Region: DrsE; cl00672
1261557006306	Selenophosphate synthetase  (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195
1261557006307	selenophosphate synthetase; Provisional; Region: PRK00943
1261557006308	dimerization interface [polypeptide binding]; other site
1261557006309	putative ATP binding site [chemical binding]; other site
1261557006310	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
1261557006311	cysteine desulfurase family protein; Region: am_tr_V_EF2568; TIGR01977
1261557006312	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1261557006313	catalytic residue [active]
1261557006314	GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182
1261557006315	Ligand binding site; other site
1261557006316	metal-binding site
1261557006317	selenium-dependent molybdenum hydroxylase 1; Region: Se_dep_Molyb_1; TIGR03311
1261557006318	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1261557006319	catalytic loop [active]
1261557006320	iron binding site [ion binding]; other site
1261557006321	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
1261557006322	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
1261557006323	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
1261557006324	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
1261557006325	XdhC Rossmann domain; Region: XdhC_C; pfam13478
1261557006326	N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005
1261557006327	xanthine permease; Region: pbuX; TIGR03173
1261557006328	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
1261557006329	homotrimer interaction site [polypeptide binding]; other site
1261557006330	putative active site [active]
1261557006331	carbamate kinase; Reviewed; Region: PRK12686
1261557006332	AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235
1261557006333	putative substrate binding site [chemical binding]; other site
1261557006334	nucleotide binding site [chemical binding]; other site
1261557006335	nucleotide binding site [chemical binding]; other site
1261557006336	homodimer interface [polypeptide binding]; other site
1261557006337	aspartate/ornithine carbamoyltransferase family protein; Validated; Region: PRK07200
1261557006338	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
1261557006339	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
1261557006340	putative selenium metabolism hydrolase; Region: selenium_YgeY; TIGR03526
1261557006341	M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like4; cd05649
1261557006342	putative metal binding site [ion binding]; other site
1261557006343	putative dimer interface [polypeptide binding]; other site
1261557006344	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cd00640
1261557006345	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1261557006346	catalytic residue [active]
1261557006347	D-hydantoinase; Region: D-hydantoinase; TIGR02033
1261557006348	D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314
1261557006349	tetramer interface [polypeptide binding]; other site
1261557006350	active site
1261557006351	putative selenate reductase, YgfK subunit; Region: Se_ygfK; TIGR03315
1261557006352	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1261557006353	putative chlorohydrolase/aminohydrolase; Validated; Region: PRK07203
1261557006354	TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298
1261557006355	active site
1261557006356	putative substrate binding pocket [chemical binding]; other site
1261557006357	YheO-like PAS domain; Region: PAS_6; pfam08348
1261557006358	HTH domain; Region: HTH_22; pfam13309
1261557006359	UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769
1261557006360	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1261557006361	Domain of unknown function (DUF1727); Region: DUF1727; pfam08353
1261557006362	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
1261557006363	catalytic triad [active]
1261557006364	NH_3: A subgroup of nucleoside hydrolases. This group contains eukaryotic and bacterial proteins similar to nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes...; Region: nuc_hydro_3; cd02653
1261557006365	active site
1261557006366	Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482
1261557006367	mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218
1261557006368	Beta-lactamase; Region: Beta-lactamase; pfam00144
1261557006369	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1261557006370	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
1261557006371	active site
1261557006372	metal binding site [ion binding]; metal-binding site
1261557006373	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1261557006374	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1261557006375	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
1261557006376	Walker A/P-loop; other site
1261557006377	ATP binding site [chemical binding]; other site
1261557006378	Q-loop/lid; other site
1261557006379	ABC transporter signature motif; other site
1261557006380	Walker B; other site
1261557006381	D-loop; other site
1261557006382	H-loop/switch region; other site
1261557006383	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1261557006384	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1261557006385	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1261557006386	Walker A/P-loop; other site
1261557006387	ATP binding site [chemical binding]; other site
1261557006388	Q-loop/lid; other site
1261557006389	ABC transporter signature motif; other site
1261557006390	Walker B; other site
1261557006391	D-loop; other site
1261557006392	H-loop/switch region; other site
1261557006393	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1261557006394	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1261557006395	Guanylate kinase; Region: Guanylate_kin; pfam00625
1261557006396	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
1261557006397	catalytic site [active]
1261557006398	G-X2-G-X-G-K; other site
1261557006399	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
1261557006400	beta-galactosidase; Region: BGL; TIGR03356
1261557006401	PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995
1261557006402	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1261557006403	active site turn [active]
1261557006404	phosphorylation site [posttranslational modification]
1261557006405	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
1261557006406	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210
1261557006407	HPr interaction site; other site
1261557006408	glycerol kinase (GK) interaction site [polypeptide binding]; other site
1261557006409	active site
1261557006410	phosphorylation site [posttranslational modification]
1261557006411	transcriptional antiterminator BglG; Provisional; Region: PRK09772
1261557006412	CAT RNA binding domain; Region: CAT_RBD; smart01061
1261557006413	PRD domain; Region: PRD; pfam00874
1261557006414	PRD domain; Region: PRD; pfam00874
1261557006415	Acyl carrier protein phosphodiesterase [Lipid metabolism]; Region: AcpD; COG1182
1261557006416	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
1261557006417	Domain of unknown function DUF20; Region: UPF0118; pfam01594
1261557006418	PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; cl01516
1261557006419	DNA-directed RNA polymerase subunit beta; Region: EpuA; pfam11772
1261557006420	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
1261557006421	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
1261557006422	hinge; other site
1261557006423	active site
1261557006424	conserved hypothetical integral membrane protein; Region: int_mem_ywzB; TIGR02327
1261557006425	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
1261557006426	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
1261557006427	gamma subunit interface [polypeptide binding]; other site
1261557006428	epsilon subunit interface [polypeptide binding]; other site
1261557006429	LBP interface [polypeptide binding]; other site
1261557006430	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
1261557006431	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
1261557006432	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
1261557006433	alpha subunit interaction interface [polypeptide binding]; other site
1261557006434	Walker A motif; other site
1261557006435	ATP binding site [chemical binding]; other site
1261557006436	Walker B motif; other site
1261557006437	inhibitor binding site; inhibition site
1261557006438	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
1261557006439	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
1261557006440	core domain interface [polypeptide binding]; other site
1261557006441	delta subunit interface [polypeptide binding]; other site
1261557006442	epsilon subunit interface [polypeptide binding]; other site
1261557006443	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
1261557006444	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
1261557006445	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
1261557006446	beta subunit interaction interface [polypeptide binding]; other site
1261557006447	Walker A motif; other site
1261557006448	ATP binding site [chemical binding]; other site
1261557006449	Walker B motif; other site
1261557006450	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
1261557006451	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
1261557006452	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
1261557006453	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
1261557006454	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
1261557006455	F0F1 ATP synthase subunit C; Validated; Region: PRK06876
1261557006456	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
1261557006457	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
1261557006458	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
1261557006459	SmpB-tmRNA interface; other site
1261557006460	ribonuclease R; Region: RNase_R; TIGR02063
1261557006461	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
1261557006462	RNB domain; Region: RNB; pfam00773
1261557006463	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
1261557006464	RNA binding site [nucleotide binding]; other site
1261557006465	Esterase/lipase [General function prediction only]; Region: COG1647
1261557006466	Preprotein translocase SecG subunit; Region: SecG; pfam03840
1261557006467	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1261557006468	Coenzyme A binding pocket [chemical binding]; other site
1261557006469	Uncharacterized conserved protein [Function unknown]; Region: COG3592
1261557006470	heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512
1261557006471	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1261557006472	Soluble P-type ATPase [General function prediction only]; Region: COG4087
1261557006473	NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171
1261557006474	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
1261557006475	homodimer interface [polypeptide binding]; other site
1261557006476	NAD binding pocket [chemical binding]; other site
1261557006477	ATP binding pocket [chemical binding]; other site
1261557006478	Mg binding site [ion binding]; other site
1261557006479	active-site loop [active]
1261557006480	nicotinate phosphoribosyltransferase; Validated; Region: PRK09243
1261557006481	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570
1261557006482	active site
1261557006483	Predicted membrane protein [Function unknown]; Region: COG2246
1261557006484	GtrA-like protein; Region: GtrA; pfam04138
1261557006485	Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705
1261557006486	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1261557006487	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
1261557006488	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1261557006489	ribonuclease Y; Region: RNase_Y; TIGR03319
1261557006490	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1261557006491	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1261557006492	DNA binding site [nucleotide binding]
1261557006493	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
1261557006494	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
1261557006495	ring oligomerisation interface [polypeptide binding]; other site
1261557006496	ATP/Mg binding site [chemical binding]; other site
1261557006497	stacking interactions; other site
1261557006498	hinge regions; other site
1261557006499	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
1261557006500	oligomerisation interface [polypeptide binding]; other site
1261557006501	mobile loop; other site
1261557006502	roof hairpin; other site
1261557006503	CAAX protease self-immunity; Region: Abi; pfam02517
1261557006504	redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472
1261557006505	Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971
1261557006506	CoA binding domain; Region: CoA_binding; pfam02629
1261557006507	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
1261557006508	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1261557006509	Walker A/P-loop; other site
1261557006510	ATP binding site [chemical binding]; other site
1261557006511	Q-loop/lid; other site
1261557006512	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1261557006513	ABC transporter signature motif; other site
1261557006514	Walker B; other site
1261557006515	D-loop; other site
1261557006516	H-loop/switch region; other site
1261557006517	ABC transporter; Region: ABC_tran_2; pfam12848
1261557006518	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1261557006519	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
1261557006520	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1261557006521	DNA-binding site [nucleotide binding]; DNA binding site
1261557006522	TrkA-C domain; Region: TrkA_C; pfam02080
1261557006523	ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175
1261557006524	ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294
1261557006525	Walker A/P-loop; other site
1261557006526	ATP binding site [chemical binding]; other site
1261557006527	Q-loop/lid; other site
1261557006528	ABC transporter signature motif; other site
1261557006529	Walker B; other site
1261557006530	D-loop; other site
1261557006531	H-loop/switch region; other site
1261557006532	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
1261557006533	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1261557006534	dimer interface [polypeptide binding]; other site
1261557006535	conserved gate region; other site
1261557006536	putative PBP binding loops; other site
1261557006537	ABC-ATPase subunit interface; other site
1261557006538	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
1261557006539	Helix-turn-helix domain; Region: HTH_38; pfam13936
1261557006540	Integrase core domain; Region: rve; pfam00665
1261557006541	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
1261557006542	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113
1261557006543	Uncharacterized protein/domain associated with GTPases [Function unknown]; Region: COG3597
1261557006544	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
1261557006545	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
1261557006546	Putative sugar diacid recognition; Region: Diacid_rec; pfam05651
1261557006547	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
1261557006548	glycerate kinase; Region: TIGR00045
1261557006549	H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610
1261557006550	fructuronate transporter; Provisional; Region: PRK10034; cl15264
1261557006551	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274
1261557006552	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
1261557006553	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
1261557006554	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
1261557006555	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1261557006556	dimer interface [polypeptide binding]; other site
1261557006557	conserved gate region; other site
1261557006558	putative PBP binding loops; other site
1261557006559	ABC-ATPase subunit interface; other site
1261557006560	2-aminoethylphosphonate transport system permease PhnU; Provisional; Region: PRK15050
1261557006561	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1261557006562	dimer interface [polypeptide binding]; other site
1261557006563	conserved gate region; other site
1261557006564	putative PBP binding loops; other site
1261557006565	ABC-ATPase subunit interface; other site
1261557006566	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
1261557006567	ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300
1261557006568	Walker A/P-loop; other site
1261557006569	ATP binding site [chemical binding]; other site
1261557006570	Q-loop/lid; other site
1261557006571	ABC transporter signature motif; other site
1261557006572	Walker B; other site
1261557006573	D-loop; other site
1261557006574	H-loop/switch region; other site
1261557006575	TOBE domain; Region: TOBE_2; pfam08402
1261557006576	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1261557006577	non-specific DNA binding site [nucleotide binding]; other site
1261557006578	salt bridge; other site
1261557006579	sequence-specific DNA binding site [nucleotide binding]; other site
1261557006580	Cupin domain; Region: Cupin_2; pfam07883
1261557006581	Yhdh and yhfp-like putative quinone oxidoreductases; Region: MDR_yhdh_yhfp; cd05280
1261557006582	putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823
1261557006583	NADP binding site [chemical binding]; other site
1261557006584	dimer interface [polypeptide binding]; other site
1261557006585	DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410
1261557006586	phosphopantothenoylcysteine decarboxylase, streptococcal; Region: coaC_strep; TIGR02113
1261557006587	Flavoprotein; Region: Flavoprotein; pfam02441
1261557006588	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
1261557006589	Predicted membrane protein [Function unknown]; Region: COG4684
1261557006590	FemAB family; Region: FemAB; pfam02388
1261557006591	QueT transporter; Region: QueT; pfam06177
1261557006592	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
1261557006593	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
1261557006594	helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448
1261557006595	AAA domain; Region: AAA_30; pfam13604
1261557006596	Family description; Region: UvrD_C_2; pfam13538
1261557006597	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1261557006598	catalytic core [active]
1261557006599	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
1261557006600	23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088
1261557006601	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1261557006602	S-adenosylmethionine binding site [chemical binding]; other site
1261557006603	Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142
1261557006604	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
1261557006605	MgtE intracellular N domain; Region: MgtE_N; pfam03448
1261557006606	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
1261557006607	Divalent cation transporter; Region: MgtE; pfam01769
1261557006608	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
1261557006609	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
1261557006610	active site
1261557006611	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885
1261557006612	ATP-NAD kinase; Region: NAD_kinase; pfam01513
1261557006613	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
1261557006614	synthetase active site [active]
1261557006615	NTP binding site [chemical binding]; other site
1261557006616	metal binding site [ion binding]; metal-binding site
1261557006617	Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762
1261557006618	putative active site [active]
1261557006619	putative metal binding residues [ion binding]; other site
1261557006620	signature motif; other site
1261557006621	putative triphosphate binding site [ion binding]; other site
1261557006622	DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025
1261557006623	catalytic residues [active]
1261557006624	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1261557006625	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1261557006626	non-specific DNA binding site [nucleotide binding]; other site
1261557006627	salt bridge; other site
1261557006628	sequence-specific DNA binding site [nucleotide binding]; other site
1261557006629	Oligoendopeptidase F [Amino acid transport and metabolism]; Region: COG1164
1261557006630	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608
1261557006631	active site
1261557006632	Zn binding site [ion binding]; other site
1261557006633	Competence protein CoiA-like family; Region: CoiA; pfam06054
1261557006634	adaptor protein; Provisional; Region: PRK02315
1261557006635	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
1261557006636	Helix-turn-helix domain; Region: HTH_38; pfam13936
1261557006637	Integrase core domain; Region: rve; pfam00665
1261557006638	Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032
1261557006639	ArsC family; Region: ArsC; pfam03960
1261557006640	putative catalytic residues [active]
1261557006641	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
1261557006642	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
1261557006643	active site
1261557006644	HIGH motif; other site
1261557006645	dimer interface [polypeptide binding]; other site
1261557006646	KMSKS motif; other site
1261557006647	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1261557006648	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1261557006649	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
1261557006650	Walker A/P-loop; other site
1261557006651	ATP binding site [chemical binding]; other site
1261557006652	Q-loop/lid; other site
1261557006653	ABC transporter signature motif; other site
1261557006654	Walker B; other site
1261557006655	D-loop; other site
1261557006656	H-loop/switch region; other site
1261557006657	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
1261557006658	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1261557006659	motif II; other site
1261557006660	Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030
1261557006661	Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797
1261557006662	WxL domain surface cell wall-binding; Region: WxL; pfam13731
1261557006663	WxL domain surface cell wall-binding; Region: WxL; pfam13731
1261557006664	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
1261557006665	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
1261557006666	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
1261557006667	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
1261557006668	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
1261557006669	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
1261557006670	LRR adjacent; Region: LRR_adjacent; pfam08191
1261557006671	WxL domain surface cell wall-binding; Region: WxL; pfam13731
1261557006672	Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455
1261557006673	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
1261557006674	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1261557006675	ATP binding site [chemical binding]; other site
1261557006676	putative Mg++ binding site [ion binding]; other site
1261557006677	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1261557006678	nucleotide binding region [chemical binding]; other site
1261557006679	ATP-binding site [chemical binding]; other site
1261557006680	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1261557006681	AAA domain; Region: AAA_23; pfam13476
1261557006682	Walker A/P-loop; other site
1261557006683	ATP binding site [chemical binding]; other site
1261557006684	Q-loop/lid; other site
1261557006685	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419
1261557006686	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1261557006687	ABC transporter signature motif; other site
1261557006688	Walker B; other site
1261557006689	D-loop; other site
1261557006690	H-loop/switch region; other site
1261557006691	DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420
1261557006692	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
1261557006693	active site
1261557006694	metal binding site [ion binding]; metal-binding site
1261557006695	DNA binding site [nucleotide binding]
1261557006696	Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320
1261557006697	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
1261557006698	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
1261557006699	putative acyl-acceptor binding pocket; other site
1261557006700	Predicted O-methyltransferase [General function prediction only]; Region: COG4123
1261557006701	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1261557006702	S-adenosylmethionine binding site [chemical binding]; other site
1261557006703	The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456
1261557006704	GIY-YIG motif/motif A; other site
1261557006705	putative active site [active]
1261557006706	putative metal binding site [ion binding]; other site
1261557006707	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584
1261557006708	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704
1261557006709	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
1261557006710	dimer interface [polypeptide binding]; other site
1261557006711	ADP-ribose binding site [chemical binding]; other site
1261557006712	active site
1261557006713	nudix motif; other site
1261557006714	metal binding site [ion binding]; metal-binding site
1261557006715	5-bromo-4-chloroindolyl phosphate hydrolysis protein; Region: Halogen_Hydrol; pfam10112
1261557006716	Toxic anion resistance protein (TelA); Region: TelA; pfam05816
1261557006717	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
1261557006718	nudix motif; other site
1261557006719	Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523
1261557006720	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1261557006721	Coenzyme A binding pocket [chemical binding]; other site
1261557006722	Transcriptional regulator [Transcription]; Region: LytR; COG1316
1261557006723	A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194
1261557006724	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
1261557006725	minor groove reading motif; other site
1261557006726	helix-hairpin-helix signature motif; other site
1261557006727	substrate binding pocket [chemical binding]; other site
1261557006728	active site
1261557006729	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
1261557006730	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
1261557006731	DNA binding and oxoG recognition site [nucleotide binding]
1261557006732	recombination regulator RecX; Provisional; Region: recX; PRK14135
1261557006733	TRAM domain; Region: TRAM; pfam01938
1261557006734	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
1261557006735	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1261557006736	S-adenosylmethionine binding site [chemical binding]; other site
1261557006737	Predicted membrane protein [Function unknown]; Region: COG2261
1261557006738	cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340
1261557006739	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
1261557006740	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
1261557006741	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
1261557006742	Beta galactosidase small chain; Region: Bgal_small_N; smart01038
1261557006743	Amino acid permease; Region: AA_permease_2; pfam13520
1261557006744	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1261557006745	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1261557006746	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1261557006747	Glucosyl transferase GtrII; Region: Glucos_trans_II; pfam14264
1261557006748	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
1261557006749	core dimer interface [polypeptide binding]; other site
1261557006750	peripheral dimer interface [polypeptide binding]; other site
1261557006751	L10 interface [polypeptide binding]; other site
1261557006752	L11 interface [polypeptide binding]; other site
1261557006753	putative EF-Tu interaction site [polypeptide binding]; other site
1261557006754	putative EF-G interaction site [polypeptide binding]; other site
1261557006755	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
1261557006756	23S rRNA interface [nucleotide binding]; other site
1261557006757	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
1261557006758	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
1261557006759	mRNA/rRNA interface [nucleotide binding]; other site
1261557006760	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
1261557006761	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
1261557006762	23S rRNA interface [nucleotide binding]; other site
1261557006763	L7/L12 interface [polypeptide binding]; other site
1261557006764	putative thiostrepton binding site; other site
1261557006765	L25 interface [polypeptide binding]; other site
1261557006766	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
1261557006767	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1261557006768	ABC transporter; Region: ABC_tran_2; pfam12848
1261557006769	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1261557006770	L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719
1261557006771	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
1261557006772	C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903
1261557006773	putative L-serine binding site [chemical binding]; other site
1261557006774	Serine dehydratase alpha chain; Region: SDH_alpha; cl12120
1261557006775	L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760
1261557006776	Peptidase M55, D-aminopeptidase dipeptide-binding protein family; Region: DAP_dppA_2; cd08769
1261557006777	SxDxEG motif; other site
1261557006778	putative active site [active]
1261557006779	putative metal binding site [ion binding]; other site
1261557006780	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
1261557006781	M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656
1261557006782	oligomer interface [polypeptide binding]; other site
1261557006783	active site
1261557006784	metal binding site [ion binding]; metal-binding site
1261557006785	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
1261557006786	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
1261557006787	peptide binding site [polypeptide binding]; other site
1261557006788	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
1261557006789	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
1261557006790	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
1261557006791	putative active site [active]
1261557006792	Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028
1261557006793	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
1261557006794	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
1261557006795	putative homodimer interface [polypeptide binding]; other site
1261557006796	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
1261557006797	heterodimer interface [polypeptide binding]; other site
1261557006798	homodimer interface [polypeptide binding]; other site
1261557006799	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597
1261557006800	50S ribosomal protein L33; Validated; Region: rpmG; PRK00504
1261557006801	FOG: CBS domain [General function prediction only]; Region: COG0517
1261557006802	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
1261557006803	conserved hypothetical integral membrane protein; Region: TIGR03766
1261557006804	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
1261557006805	FAD binding domain; Region: FAD_binding_4; pfam01565
1261557006806	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
1261557006807	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1261557006808	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1261557006809	Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087
1261557006810	active site
1261557006811	putative catalytic site [active]
1261557006812	DNA binding site [nucleotide binding]
1261557006813	putative phosphate binding site [ion binding]; other site
1261557006814	metal binding site A [ion binding]; metal-binding site
1261557006815	AP binding site [nucleotide binding]; other site
1261557006816	metal binding site B [ion binding]; metal-binding site
1261557006817	an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130
1261557006818	active site
1261557006819	catalytic site [active]
1261557006820	substrate binding site [chemical binding]; other site
1261557006821	putative alkyl hydroperoxide reductase F subunit; Region: AhpF_homolog; TIGR03143
1261557006822	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1261557006823	Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974
1261557006824	catalytic residue [active]
1261557006825	TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026
1261557006826	catalytic residues [active]
1261557006827	peroxiredoxin; Region: AhpC; TIGR03137
1261557006828	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
1261557006829	dimer interface [polypeptide binding]; other site
1261557006830	decamer (pentamer of dimers) interface [polypeptide binding]; other site
1261557006831	catalytic triad [active]
1261557006832	peroxidatic and resolving cysteines [active]
1261557006833	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
1261557006834	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1261557006835	S-adenosylmethionine binding site [chemical binding]; other site
1261557006836	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
1261557006837	lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545
1261557006838	Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437
1261557006839	Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234
1261557006840	putative hydrolase; Provisional; Region: PRK02113
1261557006841	Protein of unknown function (DUF975); Region: DUF975; cl10504
1261557006842	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
1261557006843	M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656
1261557006844	oligomer interface [polypeptide binding]; other site
1261557006845	active site
1261557006846	metal binding site [ion binding]; metal-binding site
1261557006847	D-alanyl-lipoteichoic acid biosynthesis protein DltD; Region: LTA_DltD; TIGR04092
1261557006848	DltD N-terminal region; Region: DltD_N; pfam04915
1261557006849	DltD central region; Region: DltD_M; pfam04918
1261557006850	DltD C-terminal region; Region: DltD_C; pfam04914
1261557006851	D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087
1261557006852	D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091
1261557006853	D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813
1261557006854	D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945
1261557006855	acyl-activating enzyme (AAE) consensus motif; other site
1261557006856	AMP binding site [chemical binding]; other site
1261557006857	D-Ala-teichoic acid biosynthesis protein; Region: DUF3687; pfam12459
1261557006858	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
1261557006859	FtsX-like permease family; Region: FtsX; pfam02687
1261557006860	FtsX-like permease family; Region: FtsX; pfam02687
1261557006861	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1261557006862	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1261557006863	Walker A/P-loop; other site
1261557006864	ATP binding site [chemical binding]; other site
1261557006865	Q-loop/lid; other site
1261557006866	ABC transporter signature motif; other site
1261557006867	Walker B; other site
1261557006868	D-loop; other site
1261557006869	H-loop/switch region; other site
1261557006870	anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263
1261557006871	ATP cone domain; Region: ATP-cone; pfam03477
1261557006872	Class III ribonucleotide reductase; Region: RNR_III; cd01675
1261557006873	effector binding site; other site
1261557006874	active site
1261557006875	Zn binding site [ion binding]; other site
1261557006876	glycine loop; other site
1261557006877	anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804
1261557006878	4Fe-4S single cluster domain; Region: Fer4_12; pfam13353
1261557006879	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
1261557006880	active site
1261557006881	DNA polymerase IV; Validated; Region: PRK02406
1261557006882	DNA binding site [nucleotide binding]
1261557006883	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390
1261557006884	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1261557006885	putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
1261557006886	Walker A/P-loop; other site
1261557006887	ATP binding site [chemical binding]; other site
1261557006888	Q-loop/lid; other site
1261557006889	ABC transporter signature motif; other site
1261557006890	Walker B; other site
1261557006891	D-loop; other site
1261557006892	H-loop/switch region; other site
1261557006893	Predicted methyltransferases [General function prediction only]; Region: COG0313
1261557006894	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
1261557006895	putative SAM binding site [chemical binding]; other site
1261557006896	putative homodimer interface [polypeptide binding]; other site
1261557006897	Protein of unknown function (DUF972); Region: DUF972; pfam06156
1261557006898	Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774
1261557006899	DNA polymerase III subunit delta'; Validated; Region: PRK08058
1261557006900	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1261557006901	Walker A motif; other site
1261557006902	ATP binding site [chemical binding]; other site
1261557006903	Walker B motif; other site
1261557006904	arginine finger; other site
1261557006905	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3870
1261557006906	thymidylate kinase; Validated; Region: tmk; PRK00698
1261557006907	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
1261557006908	TMP-binding site; other site
1261557006909	ATP-binding site [chemical binding]; other site
1261557006910	recombination protein RecR; Reviewed; Region: recR; PRK00076
1261557006911	RecR protein; Region: RecR; pfam02132
1261557006912	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
1261557006913	putative active site [active]
1261557006914	putative metal-binding site [ion binding]; other site
1261557006915	tetramer interface [polypeptide binding]; other site
1261557006916	Putative transcription activator [Transcription]; Region: TenA; COG0819
1261557006917	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
1261557006918	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
1261557006919	Walker A/P-loop; other site
1261557006920	ATP binding site [chemical binding]; other site
1261557006921	Q-loop/lid; other site
1261557006922	ABC transporter signature motif; other site
1261557006923	Walker B; other site
1261557006924	D-loop; other site
1261557006925	H-loop/switch region; other site
1261557006926	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4136
1261557006927	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
1261557006928	Walker A/P-loop; other site
1261557006929	ATP binding site [chemical binding]; other site
1261557006930	Q-loop/lid; other site
1261557006931	ABC transporter signature motif; other site
1261557006932	Walker B; other site
1261557006933	D-loop; other site
1261557006934	H-loop/switch region; other site
1261557006935	ABC-type cobalt transport system, permease component; Region: ABC_cobalt; cl01943
1261557006936	TraX protein; Region: TraX; cl05434
1261557006937	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1261557006938	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1261557006939	putative substrate translocation pore; other site
1261557006940	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
1261557006941	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1261557006942	putative substrate translocation pore; other site
1261557006943	Predicted transcriptional regulators [Transcription]; Region: COG1733
1261557006944	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1261557006945	putative DNA binding site [nucleotide binding]; other site
1261557006946	putative Zn2+ binding site [ion binding]; other site
1261557006947	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
1261557006948	dimer interface [polypeptide binding]; other site
1261557006949	substrate binding site [chemical binding]; other site
1261557006950	ATP binding site [chemical binding]; other site
1261557006951	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
1261557006952	thiamine phosphate binding site [chemical binding]; other site
1261557006953	active site
1261557006954	pyrophosphate binding site [ion binding]; other site
1261557006955	4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170
1261557006956	substrate binding site [chemical binding]; other site
1261557006957	multimerization interface [polypeptide binding]; other site
1261557006958	ATP binding site [chemical binding]; other site
1261557006959	thiW protein; Region: thiW; TIGR02359
1261557006960	hypothetical protein; Validated; Region: PRK00153
1261557006961	DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563
1261557006962	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1261557006963	Walker A motif; other site
1261557006964	ATP binding site [chemical binding]; other site
1261557006965	Walker B motif; other site
1261557006966	arginine finger; other site
1261557006967	galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270
1261557006968	Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087
1261557006969	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
1261557006970	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
1261557006971	NAD binding site [chemical binding]; other site
1261557006972	homodimer interface [polypeptide binding]; other site
1261557006973	active site
1261557006974	substrate binding site [chemical binding]; other site
1261557006975	Protein of unknown function (DUF3042); Region: DUF3042; pfam11240
1261557006976	FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454
1261557006977	Uncharacterized conserved protein [Function unknown]; Region: COG3189
1261557006978	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
1261557006979	active site residue [active]
1261557006980	ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744
1261557006981	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
1261557006982	nucleotide binding site [chemical binding]; other site
1261557006983	Bacterial protein of unknown function (DUF910); Region: DUF910; pfam06014
1261557006984	Rhomboid family; Region: Rhomboid; pfam01694
1261557006985	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
1261557006986	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
1261557006987	esterase; Provisional; Region: PRK10566
1261557006988	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1261557006989	Protein of unknown function (DUF805); Region: DUF805; pfam05656
1261557006990	conserved hypothetical integral membrane protein; Region: TIGR03766
1261557006991	conserved hypothetical integral membrane protein; Region: TIGR03766
1261557006992	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1261557006993	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
1261557006994	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
1261557006995	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
1261557006996	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
1261557006997	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1261557006998	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
1261557006999	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
1261557007000	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
1261557007001	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
1261557007002	active site
1261557007003	dimer interface [polypeptide binding]; other site
1261557007004	motif 1; other site
1261557007005	motif 2; other site
1261557007006	motif 3; other site
1261557007007	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
1261557007008	anticodon binding site; other site
1261557007009	4-oxalocrotonate tautomerase; Provisional; Region: PRK02220
1261557007010	active site 1 [active]
1261557007011	dimer interface [polypeptide binding]; other site
1261557007012	hexamer interface [polypeptide binding]; other site
1261557007013	active site 2 [active]
1261557007014	D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557
1261557007015	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1261557007016	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1261557007017	dimer interface [polypeptide binding]; other site
1261557007018	phosphorylation site [posttranslational modification]
1261557007019	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1261557007020	ATP binding site [chemical binding]; other site
1261557007021	Mg2+ binding site [ion binding]; other site
1261557007022	G-X-G motif; other site
1261557007023	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1261557007024	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1261557007025	active site
1261557007026	phosphorylation site [posttranslational modification]
1261557007027	intermolecular recognition site; other site
1261557007028	dimerization interface [polypeptide binding]; other site
1261557007029	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1261557007030	DNA binding site [nucleotide binding]
1261557007031	Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229
1261557007032	Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229
1261557007033	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
1261557007034	Streptomycin adenylyltransferase; Region: Adenyl_transf; pfam04439
1261557007035	Uncharacterized conserved protein [Function unknown]; Region: COG1434
1261557007036	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
1261557007037	putative active site [active]
1261557007038	Endo-beta-N-acetylglucosaminidases are bacterial chitinases that hydrolyze the chitin core of various asparagine (N)-linked glycans and glycoproteins. The endo-beta-N-acetylglucosaminidases have a glycosyl hydrolase family 18 (GH18) catalytic domain; Region: GH18_EndoS-like; cd06542
1261557007039	active site
1261557007040	Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704
1261557007041	hypothetical protein; Provisional; Region: PRK12378
1261557007042	hypothetical protein; Provisional; Region: PRK13670
1261557007043	HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673
1261557007044	Methyltransferase domain; Region: Methyltransf_23; pfam13489
1261557007045	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1261557007046	S-adenosylmethionine binding site [chemical binding]; other site
1261557007047	Oligomerisation domain; Region: Oligomerisation; cl00519
1261557007048	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1261557007049	Zn2+ binding site [ion binding]; other site
1261557007050	Mg2+ binding site [ion binding]; other site
1261557007051	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
1261557007052	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
1261557007053	active site
1261557007054	(T/H)XGH motif; other site
1261557007055	Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534
1261557007056	GTPase YqeH; Provisional; Region: PRK13796
1261557007057	Circularly permuted YqeH GTPase; Region: YqeH; cd01855
1261557007058	GTP/Mg2+ binding site [chemical binding]; other site
1261557007059	G4 box; other site
1261557007060	G5 box; other site
1261557007061	G1 box; other site
1261557007062	Switch I region; other site
1261557007063	G2 box; other site
1261557007064	G3 box; other site
1261557007065	Switch II region; other site
1261557007066	Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179
1261557007067	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1261557007068	active site
1261557007069	motif I; other site
1261557007070	motif II; other site
1261557007071	acetyl-CoA carboxylase subunit alpha; Provisional; Region: PRK12319
1261557007072	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
1261557007073	Uncharacterized protein family UPF0547; Region: UPF0547; pfam10571
1261557007074	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
1261557007075	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
1261557007076	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1261557007077	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
1261557007078	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
1261557007079	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
1261557007080	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
1261557007081	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
1261557007082	carboxyltransferase (CT) interaction site; other site
1261557007083	biotinylation site [posttranslational modification]; other site
1261557007084	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314
1261557007085	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
1261557007086	dimer interface [polypeptide binding]; other site
1261557007087	active site
1261557007088	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
1261557007089	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
1261557007090	NAD(P) binding site [chemical binding]; other site
1261557007091	homotetramer interface [polypeptide binding]; other site
1261557007092	homodimer interface [polypeptide binding]; other site
1261557007093	active site
1261557007094	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
1261557007095	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
1261557007096	putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151
1261557007097	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
1261557007098	FMN binding site [chemical binding]; other site
1261557007099	substrate binding site [chemical binding]; other site
1261557007100	putative catalytic residue [active]
1261557007101	acyl carrier protein; Provisional; Region: acpP; PRK00982
1261557007102	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
1261557007103	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
1261557007104	dimer interface [polypeptide binding]; other site
1261557007105	active site
1261557007106	CoA binding pocket [chemical binding]; other site
1261557007107	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1261557007108	MarR family; Region: MarR_2; pfam12802
1261557007109	Protein of unknown function (DUF1797); Region: DUF1797; pfam08796
1261557007110	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
1261557007111	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
1261557007112	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1261557007113	This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817
1261557007114	putative ADP-binding pocket [chemical binding]; other site
1261557007115	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1261557007116	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
1261557007117	general stress protein 13; Validated; Region: PRK08059
1261557007118	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
1261557007119	RNA binding site [nucleotide binding]; other site
1261557007120	Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168
1261557007121	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1261557007122	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1261557007123	homodimer interface [polypeptide binding]; other site
1261557007124	catalytic residue [active]
1261557007125	Protein of unknown function (DUF3955); Region: DUF3955; pfam13127
1261557007126	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
1261557007127	active site
1261557007128	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
1261557007129	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1261557007130	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1261557007131	Phosphoglycerate Dehydrogenase, 2-hydroxyacid dehydrogenase family; Region: PGDH_1; cd12155
1261557007132	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
1261557007133	putative ligand binding site [chemical binding]; other site
1261557007134	NAD binding site [chemical binding]; other site
1261557007135	catalytic site [active]
1261557007136	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
1261557007137	Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410
1261557007138	active site
1261557007139	metal binding site [ion binding]; metal-binding site
1261557007140	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
1261557007141	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1261557007142	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
1261557007143	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
1261557007144	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
1261557007145	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1261557007146	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1261557007147	dimer interface [polypeptide binding]; other site
1261557007148	conserved gate region; other site
1261557007149	putative PBP binding loops; other site
1261557007150	ABC-ATPase subunit interface; other site
1261557007151	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1261557007152	dimer interface [polypeptide binding]; other site
1261557007153	conserved gate region; other site
1261557007154	putative PBP binding loops; other site
1261557007155	ABC-ATPase subunit interface; other site
1261557007156	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
1261557007157	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
1261557007158	Walker A/P-loop; other site
1261557007159	ATP binding site [chemical binding]; other site
1261557007160	Q-loop/lid; other site
1261557007161	ABC transporter signature motif; other site
1261557007162	Walker B; other site
1261557007163	D-loop; other site
1261557007164	H-loop/switch region; other site
1261557007165	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
1261557007166	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
1261557007167	Ligand binding site; other site
1261557007168	Putative Catalytic site; other site
1261557007169	DXD motif; other site
1261557007170	Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400
1261557007171	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
1261557007172	TrkA-N domain; Region: TrkA_N; pfam02254
1261557007173	TrkA-C domain; Region: TrkA_C; pfam02080
1261557007174	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1261557007175	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1261557007176	active site
1261557007177	phosphorylation site [posttranslational modification]
1261557007178	intermolecular recognition site; other site
1261557007179	dimerization interface [polypeptide binding]; other site
1261557007180	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1261557007181	DNA binding residues [nucleotide binding]
1261557007182	dimerization interface [polypeptide binding]; other site
1261557007183	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
1261557007184	Histidine kinase; Region: HisKA_3; pfam07730
1261557007185	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1261557007186	ATP binding site [chemical binding]; other site
1261557007187	Mg2+ binding site [ion binding]; other site
1261557007188	G-X-G motif; other site
1261557007189	Predicted membrane protein [Function unknown]; Region: COG4758
1261557007190	Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922
1261557007191	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
1261557007192	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
1261557007193	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
1261557007194	YceG-like family; Region: YceG; pfam02618
1261557007195	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
1261557007196	dimerization interface [polypeptide binding]; other site
1261557007197	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
1261557007198	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1261557007199	motif II; other site
1261557007200	UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381
1261557007201	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
1261557007202	active site
1261557007203	homodimer interface [polypeptide binding]; other site
1261557007204	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
1261557007205	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
1261557007206	trimer interface [polypeptide binding]; other site
1261557007207	putative metal binding site [ion binding]; other site
1261557007208	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1261557007209	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1261557007210	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
1261557007211	Walker A/P-loop; other site
1261557007212	ATP binding site [chemical binding]; other site
1261557007213	Q-loop/lid; other site
1261557007214	ABC transporter signature motif; other site
1261557007215	Walker B; other site
1261557007216	D-loop; other site
1261557007217	H-loop/switch region; other site
1261557007218	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1261557007219	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1261557007220	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1261557007221	Walker A/P-loop; other site
1261557007222	ATP binding site [chemical binding]; other site
1261557007223	Q-loop/lid; other site
1261557007224	ABC transporter signature motif; other site
1261557007225	Walker B; other site
1261557007226	D-loop; other site
1261557007227	H-loop/switch region; other site
1261557007228	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832
1261557007229	Protein of unknown function (DUF1447); Region: DUF1447; pfam07288
1261557007230	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
1261557007231	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
1261557007232	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
1261557007233	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
1261557007234	DNA-binding site [nucleotide binding]; DNA binding site
1261557007235	RNA-binding motif; other site
1261557007236	Protein of unknown function (DUF3800); Region: DUF3800; pfam12686
1261557007237	Cpl-1 lysin (also known as Cpl-9 lysozyme / muramidase) is a bacterial cell wall endolysin encoded by the pneumococcal bacteriophage Cp-1, which cleaves the glycosidic N-acetylmuramoyl-(beta1,4)-N-acetylglucosamine bonds of the pneumococcal glycan chain; Region: GH25_Cpl1-like; cd06415
1261557007238	Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183
1261557007239	active site
1261557007240	LysM domain/BON superfamily protein; Provisional; Region: PRK11198
1261557007241	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1261557007242	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1261557007243	Haemolysin XhlA; Region: XhlA; pfam10779
1261557007244	Phage uncharacterized protein (Phage_XkdX); Region: Phage_XkdX; pfam09693
1261557007245	Phage-related protein [Function unknown]; Region: PblB; COG4926
1261557007246	Prophage endopeptidase tail; Region: Prophage_tail; cl12123
1261557007247	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
1261557007248	Peptidase family M23; Region: Peptidase_M23; pfam01551
1261557007249	Phage tail protein; Region: Sipho_tail; cl17486
1261557007250	Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145
1261557007251	phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603
1261557007252	phage protein, HK97 gp10 family; Region: phge_HK97_gp10; TIGR01725
1261557007253	Phage head-tail joining protein; Region: Phage_H_T_join; cl11461
1261557007254	Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054
1261557007255	oligomerization interface [polypeptide binding]; other site
1261557007256	phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554
1261557007257	Phage capsid family; Region: Phage_capsid; pfam05065
1261557007258	Caudovirus prohead protease; Region: Peptidase_U35; pfam04586
1261557007259	phage portal protein, HK97 family; Region: portal_HK97; TIGR01537
1261557007260	Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626
1261557007261	Rho termination factor, N-terminal domain; Region: Rho_N; cl06505
1261557007262	phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637
1261557007263	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
1261557007264	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
1261557007265	Int/Topo IB signature motif; other site
1261557007266	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
1261557007267	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
1261557007268	substrate interaction site [chemical binding]; other site
1261557007269	Protein of unknown function (DUF1064); Region: DUF1064; pfam06356
1261557007270	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1261557007271	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
1261557007272	Walker A motif; other site
1261557007273	ATP binding site [chemical binding]; other site
1261557007274	Walker B motif; other site
1261557007275	Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935
1261557007276	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1261557007277	DNA-binding site [nucleotide binding]; DNA binding site
1261557007278	Replication initiation and membrane attachment; Region: DnaB_2; cl12121
1261557007279	PDDEXK-like domain of unknown function (DUF3799); Region: DUF3799; pfam12684
1261557007280	PDDEXK-like domain of unknown function (DUF3799); Region: DUF3799; pfam12684
1261557007281	RecT family; Region: RecT; pfam03837
1261557007282	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
1261557007283	non-specific DNA binding site [nucleotide binding]; other site
1261557007284	salt bridge; other site
1261557007285	sequence-specific DNA binding site [nucleotide binding]; other site
1261557007286	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1261557007287	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1261557007288	non-specific DNA binding site [nucleotide binding]; other site
1261557007289	salt bridge; other site
1261557007290	sequence-specific DNA binding site [nucleotide binding]; other site
1261557007291	Domain of unknown function (DUF955); Region: DUF955; pfam06114
1261557007292	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
1261557007293	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
1261557007294	catalytic residues [active]
1261557007295	catalytic nucleophile [active]
1261557007296	Recombinase; Region: Recombinase; pfam07508
1261557007297	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
1261557007298	hypothetical protein; Reviewed; Region: PRK00024
1261557007299	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
1261557007300	MPN+ (JAMM) motif; other site
1261557007301	Zinc-binding site [ion binding]; other site
1261557007302	beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009
1261557007303	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1261557007304	motif II; other site
1261557007305	folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499
1261557007306	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1261557007307	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1261557007308	Bacterial membrane protein YfhO; Region: YfhO; pfam09586
1261557007309	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
1261557007310	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
1261557007311	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1261557007312	active site
1261557007313	HIGH motif; other site
1261557007314	nucleotide binding site [chemical binding]; other site
1261557007315	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
1261557007316	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
1261557007317	active site
1261557007318	KMSKS motif; other site
1261557007319	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
1261557007320	tRNA binding surface [nucleotide binding]; other site
1261557007321	anticodon binding site; other site
1261557007322	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
1261557007323	Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
1261557007324	dimer interface [polypeptide binding]; other site
1261557007325	catalytic triad [active]
1261557007326	peroxidatic and resolving cysteines [active]
1261557007327	redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472
1261557007328	Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971
1261557007329	CoA binding domain; Region: CoA_binding; pfam02629
1261557007330	thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565
1261557007331	THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716
1261557007332	ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712
1261557007333	Ligand Binding Site [chemical binding]; other site
1261557007334	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
1261557007335	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
1261557007336	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1261557007337	NAD(P) binding site [chemical binding]; other site
1261557007338	active site
1261557007339	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
1261557007340	active site
1261557007341	substrate binding site [chemical binding]; other site
1261557007342	trimer interface [polypeptide binding]; other site
1261557007343	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
1261557007344	CoA binding site [chemical binding]; other site
1261557007345	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1261557007346	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1261557007347	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1261557007348	dimerization interface [polypeptide binding]; other site
1261557007349	Sugar transport protein; Region: Sugar_transport; pfam06800
1261557007350	D-ribose pyranase; Provisional; Region: PRK11797
1261557007351	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1261557007352	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
1261557007353	substrate binding site [chemical binding]; other site
1261557007354	dimer interface [polypeptide binding]; other site
1261557007355	ATP binding site [chemical binding]; other site
1261557007356	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1261557007357	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1261557007358	DNA binding site [nucleotide binding]
1261557007359	domain linker motif; other site
1261557007360	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
1261557007361	dimerization interface [polypeptide binding]; other site
1261557007362	ligand binding site [chemical binding]; other site
1261557007363	Protein of unknown function (DUF2424); Region: DUF2424; pfam10340
1261557007364	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
1261557007365	PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410
1261557007366	PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563
1261557007367	active site
1261557007368	P-loop; other site
1261557007369	phosphorylation site [posttranslational modification]
1261557007370	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
1261557007371	PRD domain; Region: PRD; pfam00874
1261557007372	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
1261557007373	active site
1261557007374	P-loop; other site
1261557007375	phosphorylation site [posttranslational modification]
1261557007376	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1261557007377	active site
1261557007378	phosphorylation site [posttranslational modification]
1261557007379	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
1261557007380	Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030
1261557007381	Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797
1261557007382	WxL domain surface cell wall-binding; Region: WxL; pfam13731
1261557007383	N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834
1261557007384	Amidinotransferase; Region: Amidinotransf; cl12043
1261557007385	Alkaline phosphatase homologues; Region: alkPPc; smart00098
1261557007386	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016
1261557007387	active site
1261557007388	dimer interface [polypeptide binding]; other site
1261557007389	MutS domain III; Region: MutS_III; pfam05192
1261557007390	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1261557007391	Walker A/P-loop; other site
1261557007392	ATP binding site [chemical binding]; other site
1261557007393	Q-loop/lid; other site
1261557007394	ABC transporter signature motif; other site
1261557007395	Walker B; other site
1261557007396	D-loop; other site
1261557007397	H-loop/switch region; other site
1261557007398	conserved hypothetical protein EF_0839/AHA_3917; Region: EF_0839; TIGR03581
1261557007399	uncharacterized pyridoxal phosphate-dependent enzyme; Region: selA_rel; TIGR01437
1261557007400	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1261557007401	catalytic residue [active]
1261557007402	PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613
1261557007403	PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609
1261557007404	PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830
1261557007405	active site
1261557007406	phosphorylation site [posttranslational modification]
1261557007407	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025
1261557007408	active pocket/dimerization site; other site
1261557007409	active site
1261557007410	phosphorylation site [posttranslational modification]
1261557007411	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221
1261557007412	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1261557007413	Walker A motif; other site
1261557007414	ATP binding site [chemical binding]; other site
1261557007415	Walker B motif; other site
1261557007416	arginine finger; other site
1261557007417	PRD domain; Region: PRD; pfam00874
1261557007418	Transcriptional antiterminator [Transcription]; Region: COG3933
1261557007419	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025
1261557007420	active site
1261557007421	active pocket/dimerization site; other site
1261557007422	phosphorylation site [posttranslational modification]
1261557007423	PRD domain; Region: PRD; pfam00874
1261557007424	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1261557007425	catalytic core [active]
1261557007426	amidase; Provisional; Region: PRK06529
1261557007427	Amidase; Region: Amidase; cl11426
1261557007428	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355
1261557007429	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1261557007430	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
1261557007431	FtsX-like permease family; Region: FtsX; pfam02687
1261557007432	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1261557007433	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1261557007434	Walker A/P-loop; other site
1261557007435	ATP binding site [chemical binding]; other site
1261557007436	Q-loop/lid; other site
1261557007437	ABC transporter signature motif; other site
1261557007438	Walker B; other site
1261557007439	D-loop; other site
1261557007440	H-loop/switch region; other site
1261557007441	HlyD family secretion protein; Region: HlyD_2; pfam12700
1261557007442	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
1261557007443	active site residue [active]
1261557007444	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1261557007445	CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385
1261557007446	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1261557007447	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1261557007448	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
1261557007449	active site residue [active]
1261557007450	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
1261557007451	active site residue [active]
1261557007452	Uncharacterized protein YrkD from Bacillus subtilis and related domains; this domain superfamily was previously known as part of DUF156; Region: BsYrkD-like_DUF156; cd10155
1261557007453	putative homodimer interface [polypeptide binding]; other site
1261557007454	putative homotetramer interface [polypeptide binding]; other site
1261557007455	putative metal binding site [ion binding]; other site
1261557007456	putative homodimer-homodimer interface [polypeptide binding]; other site
1261557007457	putative allosteric switch controlling residues; other site
1261557007458	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1261557007459	D-galactonate transporter; Region: 2A0114; TIGR00893
1261557007460	putative substrate translocation pore; other site
1261557007461	Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075
1261557007462	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1261557007463	catalytic residue [active]
1261557007464	Purine catabolism regulatory protein-like family; Region: PucR; pfam07905
1261557007465	Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508
1261557007466	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
1261557007467	putative allantoin catabolism protein; Region: ura-cupin; TIGR03214
1261557007468	Protein of unknown function (DUF861); Region: Cupin_3; cl17594
1261557007469	Cupin domain; Region: Cupin_2; cl17218
1261557007470	allantoate amidohydrolase; Region: AllC; TIGR03176
1261557007471	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
1261557007472	active site
1261557007473	metal binding site [ion binding]; metal-binding site
1261557007474	dimer interface [polypeptide binding]; other site
1261557007475	allantoinase; Provisional; Region: PRK08044
1261557007476	L-Hydantoinases (L-HYDs) and Allantoinase (ALN); L-Hydantoinases are a member of the dihydropyrimidinase family, which catalyzes the reversible hydrolytic ring opening of dihydropyrimidines and hydantoins (five-membered cyclic diamides used in...; Region: L-HYD_ALN; cd01315
1261557007477	active site
1261557007478	uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily, YbbW-like; solute-binding domain; Region: SLC-NCS1sbd_YbbW-like; cd11485
1261557007479	Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133
1261557007480	Na binding site [ion binding]; other site
1261557007481	putative substrate binding site [chemical binding]; other site
1261557007482	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1261557007483	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1261557007484	Coenzyme A binding pocket [chemical binding]; other site
1261557007485	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1261557007486	MarR family; Region: MarR; pfam01047
1261557007487	MarR family; Region: MarR_2; cl17246
1261557007488	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
1261557007489	Helix-turn-helix domain; Region: HTH_38; pfam13936
1261557007490	Integrase core domain; Region: rve; pfam00665
1261557007491	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
1261557007492	Sulfate transporter family; Region: Sulfate_transp; pfam00916
1261557007493	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
1261557007494	Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275
1261557007495	Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins.  PVA has an N-terminal...; Region: Ntn_PVA; cd00542
1261557007496	active site
1261557007497	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046
1261557007498	beta-galactosidase; Region: BGL; TIGR03356
1261557007499	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
1261557007500	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
1261557007501	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
1261557007502	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
1261557007503	Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592
1261557007504	DNA binding residues [nucleotide binding]
1261557007505	dimer interface [polypeptide binding]; other site
1261557007506	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400
1261557007507	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
1261557007508	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
1261557007509	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
1261557007510	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
1261557007511	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
1261557007512	Int/Topo IB signature motif; other site
1261557007513	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
1261557007514	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
1261557007515	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
1261557007516	HsdM N-terminal domain; Region: HsdM_N; pfam12161
1261557007517	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
1261557007518	Methyltransferase domain; Region: Methyltransf_26; pfam13659
1261557007519	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
1261557007520	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
1261557007521	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
1261557007522	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1261557007523	ATP binding site [chemical binding]; other site
1261557007524	putative Mg++ binding site [ion binding]; other site
1261557007525	EcsC protein family; Region: EcsC; pfam12787
1261557007526	Purine catabolism regulatory protein-like family; Region: PucR; pfam07905
1261557007527	DRTGG domain; Region: DRTGG; pfam07085
1261557007528	Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508
1261557007529	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
1261557007530	Protein of unknown function (DUF2877); Region: DUF2877; pfam11392
1261557007531	CoA binding domain; Region: CoA_binding; pfam02629
1261557007532	CoA-ligase; Region: Ligase_CoA; pfam00549
1261557007533	Protein of unknown function (DUF1116); Region: DUF1116; pfam06545
1261557007534	Mga helix-turn-helix domain; Region: Mga; pfam05043
1261557007535	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
1261557007536	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
1261557007537	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
1261557007538	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1261557007539	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
1261557007540	haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710
1261557007541	Soluble P-type ATPase [General function prediction only]; Region: COG4087
1261557007542	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
1261557007543	serine/threonine transporter SstT; Provisional; Region: PRK13628
1261557007544	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
1261557007545	Ion channel; Region: Ion_trans_2; pfam07885
1261557007546	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
1261557007547	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
1261557007548	dimerization interface 3.5A [polypeptide binding]; other site
1261557007549	active site
1261557007550	Sigma factor regulator N-terminal; Region: Sigma_reg_N; pfam13800
1261557007551	Sigma factor regulator C-terminal; Region: Sigma_reg_C; pfam13791
1261557007552	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
1261557007553	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1261557007554	DNA binding residues [nucleotide binding]
1261557007555	DinB superfamily; Region: DinB_2; pfam12867
1261557007556	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
1261557007557	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
1261557007558	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
1261557007559	Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368
1261557007560	Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues; Region: GAG_Lyase; cd01083
1261557007561	substrate binding site [chemical binding]; other site
1261557007562	catalytic residues [active]
1261557007563	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
1261557007564	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
1261557007565	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1261557007566	protein binding site [polypeptide binding]; other site
1261557007567	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
1261557007568	putative tRNA-binding site [nucleotide binding]; other site
1261557007569	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1261557007570	Ligand Binding Site [chemical binding]; other site
1261557007571	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1261557007572	catalytic residues [active]
1261557007573	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
1261557007574	M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656
1261557007575	oligomer interface [polypeptide binding]; other site
1261557007576	active site
1261557007577	metal binding site [ion binding]; metal-binding site
1261557007578	Predicted small secreted protein [Function unknown]; Region: COG5584
1261557007579	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
1261557007580	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
1261557007581	peptide binding site [polypeptide binding]; other site
1261557007582	PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613
1261557007583	PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609
1261557007584	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
1261557007585	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
1261557007586	active site
1261557007587	dimer interface [polypeptide binding]; other site
1261557007588	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
1261557007589	active site
1261557007590	phosphorylation site [posttranslational modification]
1261557007591	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
1261557007592	active pocket/dimerization site; other site
1261557007593	active site
1261557007594	phosphorylation site [posttranslational modification]
1261557007595	Acyltransferase family; Region: Acyl_transf_3; pfam01757
1261557007596	Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803
1261557007597	putative active site [active]
1261557007598	YdjC motif; other site
1261557007599	Mg binding site [ion binding]; other site
1261557007600	putative homodimer interface [polypeptide binding]; other site
1261557007601	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
1261557007602	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
1261557007603	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
1261557007604	putative active site [active]
1261557007605	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
1261557007606	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549
1261557007607	putative active site [active]
1261557007608	putative proton-coupled thiamine transporter YuaJ; Region: thia_yuaJ; TIGR02357
1261557007609	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
1261557007610	Predicted membrane protein [Function unknown]; Region: COG3212
1261557007611	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
1261557007612	Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165
1261557007613	active site
1261557007614	catalytic site [active]
1261557007615	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
1261557007616	Low molecular weight phosphatase family; Region: LMWPc; cd00115
1261557007617	active site
1261557007618	probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366
1261557007619	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1261557007620	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883
1261557007621	rod shape-determining protein MreD; Region: shape_MreD; TIGR03426
1261557007622	rod shape-determining protein MreC; Provisional; Region: PRK13922
1261557007623	rod shape-determining protein MreC; Region: MreC; pfam04085
1261557007624	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
1261557007625	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
1261557007626	RNase E interface [polypeptide binding]; other site
1261557007627	trimer interface [polypeptide binding]; other site
1261557007628	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
1261557007629	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
1261557007630	RNase E interface [polypeptide binding]; other site
1261557007631	trimer interface [polypeptide binding]; other site
1261557007632	active site
1261557007633	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
1261557007634	putative nucleic acid binding region [nucleotide binding]; other site
1261557007635	G-X-X-G motif; other site
1261557007636	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
1261557007637	RNA binding site [nucleotide binding]; other site
1261557007638	domain interface; other site
1261557007639	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
1261557007640	16S/18S rRNA binding site [nucleotide binding]; other site
1261557007641	S13e-L30e interaction site [polypeptide binding]; other site
1261557007642	25S rRNA binding site [nucleotide binding]; other site
1261557007643	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
1261557007644	active site
1261557007645	catalytic residues [active]
1261557007646	metal binding site [ion binding]; metal-binding site
1261557007647	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1261557007648	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
1261557007649	active site
1261557007650	motif I; other site
1261557007651	motif II; other site
1261557007652	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1261557007653	active site
1261557007654	motif I; other site
1261557007655	motif II; other site
1261557007656	DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713
1261557007657	A new structural DNA glycosylase containing HEAT-like repeats; Region: AlkD_like_1; cd07064
1261557007658	active site
1261557007659	Formate/nitrite transporter; Region: Form_Nir_trans; cl00927
1261557007660	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
1261557007661	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
1261557007662	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1261557007663	RNA binding surface [nucleotide binding]; other site
1261557007664	BioY family; Region: BioY; pfam02632
1261557007665	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
1261557007666	The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462
1261557007667	Catalytic site [active]
1261557007668	WxL domain surface cell wall-binding; Region: WxL; pfam13731
1261557007669	WxL domain surface cell wall-binding; Region: WxL; pfam13731
1261557007670	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4493
1261557007671	Protein of unknown function (DUF1054); Region: DUF1054; pfam06335
1261557007672	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1261557007673	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1261557007674	peptidase T; Region: peptidase-T; TIGR01882
1261557007675	M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892
1261557007676	metal binding site [ion binding]; metal-binding site
1261557007677	dimer interface [polypeptide binding]; other site
1261557007678	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
1261557007679	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
1261557007680	peptide binding site [polypeptide binding]; other site
1261557007681	ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607
1261557007682	Siderophore binding protein FatB.  These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140
1261557007683	putative ligand binding residues [chemical binding]; other site
1261557007684	ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604
1261557007685	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
1261557007686	Walker A/P-loop; other site
1261557007687	ATP binding site [chemical binding]; other site
1261557007688	Q-loop/lid; other site
1261557007689	ABC transporter signature motif; other site
1261557007690	Walker B; other site
1261557007691	D-loop; other site
1261557007692	H-loop/switch region; other site
1261557007693	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1261557007694	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1261557007695	ABC-ATPase subunit  interface; other site
1261557007696	dimer interface [polypeptide binding]; other site
1261557007697	putative PBP binding regions; other site
1261557007698	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1261557007699	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1261557007700	ABC-ATPase subunit  interface; other site
1261557007701	dimer interface [polypeptide binding]; other site
1261557007702	putative PBP binding regions; other site
1261557007703	Protein of unknown function (DUF1694); Region: DUF1694; pfam07997
1261557007704	glutamate--cysteine ligase/gamma-glutamylcysteine synthetase, Streptococcus agalactiae type; Region: glu_cys_lig_rel; TIGR01435
1261557007705	Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352
1261557007706	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1261557007707	Nicotinamidase_ related amidohydrolases.  Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014
1261557007708	Isochorismatase family; Region: Isochorismatase; pfam00857
1261557007709	catalytic triad [active]
1261557007710	conserved cis-peptide bond; other site
1261557007711	Uncharacterized conserved protein [Function unknown]; Region: COG1284
1261557007712	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
1261557007713	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
1261557007714	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
1261557007715	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012
1261557007716	Cupin superfamily (DUF985); Region: Cupin_5; pfam06172
1261557007717	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
1261557007718	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
1261557007719	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
1261557007720	P loop; other site
1261557007721	GTP binding site [chemical binding]; other site
1261557007722	sugar phosphate phosphatase; Provisional; Region: PRK10513
1261557007723	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1261557007724	active site
1261557007725	motif I; other site
1261557007726	motif II; other site
1261557007727	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
1261557007728	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
1261557007729	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
1261557007730	Walker A/P-loop; other site
1261557007731	ATP binding site [chemical binding]; other site
1261557007732	Q-loop/lid; other site
1261557007733	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968
1261557007734	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
1261557007735	ABC transporter signature motif; other site
1261557007736	Walker B; other site
1261557007737	D-loop; other site
1261557007738	H-loop/switch region; other site
1261557007739	ribonuclease III; Reviewed; Region: rnc; PRK00102
1261557007740	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
1261557007741	dimerization interface [polypeptide binding]; other site
1261557007742	active site
1261557007743	metal binding site [ion binding]; metal-binding site
1261557007744	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
1261557007745	dsRNA binding site [nucleotide binding]; other site
1261557007746	The substrate binding component of an ABC-type lactococcal OppA-like transport system contains; Region: PBP2_Lactococcal_OppA_like; cd08510
1261557007747	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
1261557007748	peptide binding site [polypeptide binding]; other site
1261557007749	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SapC; COG4171
1261557007750	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1261557007751	dimer interface [polypeptide binding]; other site
1261557007752	conserved gate region; other site
1261557007753	putative PBP binding loops; other site
1261557007754	ABC-ATPase subunit interface; other site
1261557007755	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1261557007756	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1261557007757	dimer interface [polypeptide binding]; other site
1261557007758	conserved gate region; other site
1261557007759	putative PBP binding loops; other site
1261557007760	ABC-ATPase subunit interface; other site
1261557007761	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
1261557007762	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1261557007763	Walker A/P-loop; other site
1261557007764	ATP binding site [chemical binding]; other site
1261557007765	Q-loop/lid; other site
1261557007766	ABC transporter signature motif; other site
1261557007767	Walker B; other site
1261557007768	D-loop; other site
1261557007769	H-loop/switch region; other site
1261557007770	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
1261557007771	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
1261557007772	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1261557007773	Walker A/P-loop; other site
1261557007774	ATP binding site [chemical binding]; other site
1261557007775	Q-loop/lid; other site
1261557007776	ABC transporter signature motif; other site
1261557007777	Walker B; other site
1261557007778	D-loop; other site
1261557007779	H-loop/switch region; other site
1261557007780	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1261557007781	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
1261557007782	Helix-turn-helix domain; Region: HTH_38; pfam13936
1261557007783	Integrase core domain; Region: rve; pfam00665
1261557007784	acyl carrier protein; Provisional; Region: acpP; PRK00982
1261557007785	putative phosphate acyltransferase; Provisional; Region: PRK05331
1261557007786	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
1261557007787	Y-family of DNA polymerases; Region: PolY; cl12025
1261557007788	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
1261557007789	generic binding surface II; other site
1261557007790	ssDNA binding site; other site
1261557007791	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1261557007792	ATP binding site [chemical binding]; other site
1261557007793	putative Mg++ binding site [ion binding]; other site
1261557007794	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1261557007795	nucleotide binding region [chemical binding]; other site
1261557007796	ATP-binding site [chemical binding]; other site
1261557007797	DAK2 domain fusion protein YloV; Region: YloV; TIGR03599
1261557007798	DAK2 domain; Region: Dak2; pfam02734
1261557007799	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302
1261557007800	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
1261557007801	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1261557007802	active site
1261557007803	phosphorylation site [posttranslational modification]
1261557007804	intermolecular recognition site; other site
1261557007805	dimerization interface [polypeptide binding]; other site
1261557007806	LytTr DNA-binding domain; Region: LytTR; pfam04397
1261557007807	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
1261557007808	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
1261557007809	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
1261557007810	Integrase core domain; Region: rve; pfam00665
1261557007811	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
1261557007812	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152
1261557007813	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1261557007814	Walker A/P-loop; other site
1261557007815	ATP binding site [chemical binding]; other site
1261557007816	Q-loop/lid; other site
1261557007817	ABC transporter signature motif; other site
1261557007818	Walker B; other site
1261557007819	D-loop; other site
1261557007820	H-loop/switch region; other site
1261557007821	Domain of unknown function (DUF4162); Region: DUF4162; pfam13732
1261557007822	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
1261557007823	Thiamine pyrophosphokinase; Region: TPK; cd07995
1261557007824	thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378
1261557007825	active site
1261557007826	dimerization interface [polypeptide binding]; other site
1261557007827	thiamine binding site [chemical binding]; other site
1261557007828	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
1261557007829	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
1261557007830	substrate binding site [chemical binding]; other site
1261557007831	hexamer interface [polypeptide binding]; other site
1261557007832	metal binding site [ion binding]; metal-binding site
1261557007833	GTPase RsgA; Reviewed; Region: PRK00098
1261557007834	S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466
1261557007835	RNA binding site [nucleotide binding]; other site
1261557007836	homodimer interface [polypeptide binding]; other site
1261557007837	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
1261557007838	GTPase/Zn-binding domain interface [polypeptide binding]; other site
1261557007839	GTP/Mg2+ binding site [chemical binding]; other site
1261557007840	G4 box; other site
1261557007841	G5 box; other site
1261557007842	G1 box; other site
1261557007843	Switch I region; other site
1261557007844	G2 box; other site
1261557007845	G3 box; other site
1261557007846	Switch II region; other site
1261557007847	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
1261557007848	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1261557007849	active site
1261557007850	ATP binding site [chemical binding]; other site
1261557007851	substrate binding site [chemical binding]; other site
1261557007852	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
1261557007853	substrate binding site [chemical binding]; other site
1261557007854	activation loop (A-loop); other site
1261557007855	activation loop (A-loop); other site
1261557007856	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815
1261557007857	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
1261557007858	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
1261557007859	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
1261557007860	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
1261557007861	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
1261557007862	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
1261557007863	active site
1261557007864	16S rRNA methyltransferase B; Provisional; Region: PRK14902
1261557007865	RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223
1261557007866	putative RNA binding site [nucleotide binding]; other site
1261557007867	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1261557007868	S-adenosylmethionine binding site [chemical binding]; other site
1261557007869	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
1261557007870	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
1261557007871	putative active site [active]
1261557007872	substrate binding site [chemical binding]; other site
1261557007873	putative cosubstrate binding site; other site
1261557007874	catalytic site [active]
1261557007875	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
1261557007876	substrate binding site [chemical binding]; other site
1261557007877	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
1261557007878	active site
1261557007879	catalytic residues [active]
1261557007880	metal binding site [ion binding]; metal-binding site
1261557007881	Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198
1261557007882	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1261557007883	ATP binding site [chemical binding]; other site
1261557007884	putative Mg++ binding site [ion binding]; other site
1261557007885	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1261557007886	nucleotide binding region [chemical binding]; other site
1261557007887	ATP-binding site [chemical binding]; other site
1261557007888	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
1261557007889	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
1261557007890	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
1261557007891	catalytic site [active]
1261557007892	G-X2-G-X-G-K; other site
1261557007893	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
1261557007894	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
1261557007895	Domain of unknown function (DUF1958); Region: DUF1958; pfam09211
1261557007896	acyl-CoA esterase; Provisional; Region: PRK10673
1261557007897	hypothetical protein; Provisional; Region: PRK11820
1261557007898	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
1261557007899	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
1261557007900	Uncharacterized protein conserved in bacteria (DUF2128); Region: DUF2128; pfam09901
1261557007901	ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553
1261557007902	2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800
1261557007903	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
1261557007904	active site
1261557007905	intersubunit interface [polypeptide binding]; other site
1261557007906	catalytic residue [active]
1261557007907	mannonate dehydratase; Provisional; Region: PRK03906
1261557007908	mannonate dehydratase; Region: uxuA; TIGR00695
1261557007909	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
1261557007910	active pocket/dimerization site; other site
1261557007911	active site
1261557007912	phosphorylation site [posttranslational modification]
1261557007913	PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830
1261557007914	active site
1261557007915	phosphorylation site [posttranslational modification]
1261557007916	PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613
1261557007917	PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609
1261557007918	Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371
1261557007919	Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172
1261557007920	putative active site [active]
1261557007921	metal binding site [ion binding]; metal-binding site
1261557007922	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
1261557007923	Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_12; cd12177
1261557007924	putative ligand binding site [chemical binding]; other site
1261557007925	putative NAD binding site [chemical binding]; other site
1261557007926	catalytic site [active]
1261557007927	Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023
1261557007928	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
1261557007929	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
1261557007930	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
1261557007931	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
1261557007932	putative active site [active]
1261557007933	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1261557007934	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1261557007935	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1261557007936	Walker A/P-loop; other site
1261557007937	ATP binding site [chemical binding]; other site
1261557007938	Q-loop/lid; other site
1261557007939	ABC transporter signature motif; other site
1261557007940	Walker B; other site
1261557007941	D-loop; other site
1261557007942	H-loop/switch region; other site
1261557007943	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1261557007944	MarR family; Region: MarR_2; pfam12802
1261557007945	CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Region: pgsA; TIGR00560
1261557007946	Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426
1261557007947	Helix-turn-helix domain; Region: HTH_25; pfam13413
1261557007948	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
1261557007949	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
1261557007950	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
1261557007951	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
1261557007952	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
1261557007953	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
1261557007954	Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970
1261557007955	WxL domain surface cell wall-binding; Region: WxL; pfam13731
1261557007956	WxL domain surface cell wall-binding; Region: WxL; pfam13731
1261557007957	trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404
1261557007958	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1261557007959	DNA-binding site [nucleotide binding]; DNA binding site
1261557007960	UTRA domain; Region: UTRA; pfam07702
1261557007961	Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554
1261557007962	Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636
1261557007963	Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632
1261557007964	Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633
1261557007965	beta-phosphoglucomutase; Region: bPGM; TIGR01990
1261557007966	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
1261557007967	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1261557007968	motif II; other site
1261557007969	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
1261557007970	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
1261557007971	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1261557007972	active site
1261557007973	methionine sulfoxide reductase B; Provisional; Region: PRK00222
1261557007974	SelR domain; Region: SelR; pfam01641
1261557007975	Maf-like protein; Region: Maf; pfam02545
1261557007976	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
1261557007977	active site
1261557007978	dimer interface [polypeptide binding]; other site
1261557007979	DNA mismatch repair enzyme (predicted ATPase) [DNA replication, recombination, and repair]; Region: MutL; COG0323
1261557007980	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1261557007981	ATP binding site [chemical binding]; other site
1261557007982	Mg2+ binding site [ion binding]; other site
1261557007983	G-X-G motif; other site
1261557007984	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
1261557007985	ATP binding site [chemical binding]; other site
1261557007986	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
1261557007987	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
1261557007988	MutS domain I; Region: MutS_I; pfam01624
1261557007989	MutS domain II; Region: MutS_II; pfam05188
1261557007990	MutS domain III; Region: MutS_III; pfam05192
1261557007991	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
1261557007992	Walker A/P-loop; other site
1261557007993	ATP binding site [chemical binding]; other site
1261557007994	Q-loop/lid; other site
1261557007995	ABC transporter signature motif; other site
1261557007996	Walker B; other site
1261557007997	D-loop; other site
1261557007998	H-loop/switch region; other site
1261557007999	Protein of unknown function (DUF964); Region: DUF964; cl01483
1261557008000	Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382
1261557008001	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1261557008002	putative active site [active]
1261557008003	metal binding site [ion binding]; metal-binding site
1261557008004	homodimer binding site [polypeptide binding]; other site
1261557008005	phosphodiesterase; Provisional; Region: PRK12704
1261557008006	Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013
1261557008007	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1261557008008	Zn2+ binding site [ion binding]; other site
1261557008009	Mg2+ binding site [ion binding]; other site
1261557008010	recombinase A; Provisional; Region: recA; PRK09354
1261557008011	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
1261557008012	hexamer interface [polypeptide binding]; other site
1261557008013	Walker A motif; other site
1261557008014	ATP binding site [chemical binding]; other site
1261557008015	Walker B motif; other site
1261557008016	competence damage-inducible protein A; Provisional; Region: PRK00549
1261557008017	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
1261557008018	putative MPT binding site; other site
1261557008019	Competence-damaged protein; Region: CinA; pfam02464
1261557008020	biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244
1261557008021	NADH(P)-binding; Region: NAD_binding_10; pfam13460
1261557008022	NAD binding site [chemical binding]; other site
1261557008023	substrate binding site [chemical binding]; other site
1261557008024	putative active site [active]
1261557008025	Predicted transcriptional regulator [Transcription]; Region: COG1959
1261557008026	Transcriptional regulator; Region: Rrf2; pfam02082
1261557008027	hypothetical protein; Provisional; Region: PRK11770
1261557008028	Domain of unknown function (DUF307); Region: DUF307; pfam03733
1261557008029	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588
1261557008030	Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659
1261557008031	metal binding site [ion binding]; metal-binding site
1261557008032	dimer interface [polypeptide binding]; other site
1261557008033	Protein of unknown function (DUF3298); Region: DUF3298; pfam11738
1261557008034	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
1261557008035	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1261557008036	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1261557008037	DNA binding residues [nucleotide binding]
1261557008038	Mga helix-turn-helix domain; Region: Mga; pfam05043
1261557008039	Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030
1261557008040	Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797
1261557008041	WxL domain surface cell wall-binding; Region: WxL; pfam13731
1261557008042	WxL domain surface cell wall-binding; Region: WxL; pfam13731
1261557008043	WxL domain surface cell wall-binding; Region: WxL; pfam13731
1261557008044	WxL domain surface cell wall-binding; Region: WxL; pfam13731
1261557008045	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
1261557008046	Helix-turn-helix domain; Region: HTH_38; pfam13936
1261557008047	Integrase core domain; Region: rve; pfam00665
1261557008048	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
1261557008049	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
1261557008050	Isochorismatase family; Region: Isochorismatase; pfam00857
1261557008051	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
1261557008052	catalytic triad [active]
1261557008053	conserved cis-peptide bond; other site
1261557008054	antiholin-like protein LrgB; Provisional; Region: PRK04288
1261557008055	murein hydrolase regulator LrgA; Provisional; Region: PRK04125
1261557008056	two-component response regulator; Provisional; Region: PRK14084
1261557008057	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1261557008058	active site
1261557008059	phosphorylation site [posttranslational modification]
1261557008060	intermolecular recognition site; other site
1261557008061	dimerization interface [polypeptide binding]; other site
1261557008062	LytTr DNA-binding domain; Region: LytTR; pfam04397
1261557008063	Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275
1261557008064	5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694
1261557008065	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
1261557008066	Histidine kinase; Region: His_kinase; pfam06580
1261557008067	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1261557008068	ATP binding site [chemical binding]; other site
1261557008069	Mg2+ binding site [ion binding]; other site
1261557008070	G-X-G motif; other site
1261557008071	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
1261557008072	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
1261557008073	ABC-type metal ion transport system, permease component [Inorganic ion transport and metabolism]; Region: AbcD; COG2011
1261557008074	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1261557008075	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
1261557008076	Walker A/P-loop; other site
1261557008077	ATP binding site [chemical binding]; other site
1261557008078	Q-loop/lid; other site
1261557008079	ABC transporter signature motif; other site
1261557008080	Walker B; other site
1261557008081	D-loop; other site
1261557008082	H-loop/switch region; other site
1261557008083	OsmC-like protein; Region: OsmC; pfam02566
1261557008084	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
1261557008085	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
1261557008086	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
1261557008087	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1261557008088	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
1261557008089	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
1261557008090	Metal binding protein AcdA.  These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017
1261557008091	metal binding site [ion binding]; metal-binding site
1261557008092	YodA lipocalin-like domain; Region: YodA; pfam09223
1261557008093	tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042
1261557008094	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
1261557008095	FMN binding site [chemical binding]; other site
1261557008096	active site
1261557008097	catalytic residues [active]
1261557008098	substrate binding site [chemical binding]; other site
1261557008099	inner membrane transport permease; Provisional; Region: PRK15066
1261557008100	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
1261557008101	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1261557008102	ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263
1261557008103	Walker A/P-loop; other site
1261557008104	ATP binding site [chemical binding]; other site
1261557008105	Q-loop/lid; other site
1261557008106	ABC transporter signature motif; other site
1261557008107	Walker B; other site
1261557008108	D-loop; other site
1261557008109	H-loop/switch region; other site
1261557008110	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025
1261557008111	active pocket/dimerization site; other site
1261557008112	active site
1261557008113	phosphorylation site [posttranslational modification]
1261557008114	PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830
1261557008115	active site
1261557008116	phosphorylation site [posttranslational modification]
1261557008117	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715
1261557008118	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716
1261557008119	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1261557008120	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
1261557008121	Walker A motif; other site
1261557008122	ATP binding site [chemical binding]; other site
1261557008123	Walker B motif; other site
1261557008124	arginine finger; other site
1261557008125	Transcriptional antiterminator [Transcription]; Region: COG3933
1261557008126	PRD domain; Region: PRD; pfam00874
1261557008127	AIPR protein; Region: AIPR; pfam10592
1261557008128	Domain of unknown function (DUF4420); Region: DUF4420; pfam14390
1261557008129	Z1 domain; Region: Z1; pfam10593
1261557008130	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c_3; pfam13589
1261557008131	ATP binding site [chemical binding]; other site
1261557008132	Mg2+ binding site [ion binding]; other site
1261557008133	G-X-G motif; other site
1261557008134	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
1261557008135	cofactor binding site; other site
1261557008136	C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145
1261557008137	DNA binding site [nucleotide binding]
1261557008138	substrate interaction site [chemical binding]; other site
1261557008139	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
1261557008140	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
1261557008141	23S rRNA interface [nucleotide binding]; other site
1261557008142	L3 interface [polypeptide binding]; other site
1261557008143	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
1261557008144	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
1261557008145	dimerization interface [polypeptide binding]; other site
1261557008146	DPS ferroxidase diiron center [ion binding]; other site
1261557008147	ion pore; other site
1261557008148	gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314
1261557008149	Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770
1261557008150	N- and C-terminal domain interface [polypeptide binding]; other site
1261557008151	active site
1261557008152	catalytic site [active]
1261557008153	metal binding site [ion binding]; metal-binding site
1261557008154	carbohydrate binding site [chemical binding]; other site
1261557008155	ATP binding site [chemical binding]; other site
1261557008156	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
1261557008157	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
1261557008158	DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566
1261557008159	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
1261557008160	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
1261557008161	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
1261557008162	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
1261557008163	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
1261557008164	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
1261557008165	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
1261557008166	DNA binding site [nucleotide binding]
1261557008167	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
1261557008168	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
1261557008169	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
1261557008170	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
1261557008171	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
1261557008172	RPB1 interaction site [polypeptide binding]; other site
1261557008173	RPB10 interaction site [polypeptide binding]; other site
1261557008174	RPB11 interaction site [polypeptide binding]; other site
1261557008175	RPB3 interaction site [polypeptide binding]; other site
1261557008176	RPB12 interaction site [polypeptide binding]; other site
1261557008177	PemK-like protein; Region: PemK; pfam02452
1261557008178	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082); Region: DUF2082; pfam09855
1261557008179	Biotin operon repressor [Transcription]; Region: BirA; COG1654
1261557008180	bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886
1261557008181	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
1261557008182	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
1261557008183	Chitin binding domain; Region: Chitin_bind_3; pfam03067
1261557008184	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
1261557008185	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
1261557008186	active site
1261557008187	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581
1261557008188	WxL domain surface cell wall-binding; Region: WxL; pfam13731
1261557008189	1,4-dihydroxy-2-naphthoate octaprenyltransferase; Provisional; Region: PRK13387
1261557008190	UbiA prenyltransferase family; Region: UbiA; pfam01040
1261557008191	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
1261557008192	ApbE family; Region: ApbE; pfam02424
1261557008193	This conserved region includes the FMN-binding site of the NqrC protein as well as the NosR and NirI regulatory proteins; Region: FMN_bind; smart00900
1261557008194	FMN-binding domain; Region: FMN_bind; pfam04205
1261557008195	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
1261557008196	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1261557008197	Listerrria innocua Lin0431  is similar to the N-Utilization Substance G (NusG) N terminal (NGN) insert (DII); Region: Lin0431_like; cd09911
1261557008198	trimer interface [polypeptide binding]; other site
1261557008199	Heptaprenyl diphosphate synthase component I; Region: Hpre_diP_synt_I; pfam07456
1261557008200	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
1261557008201	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
1261557008202	substrate binding pocket [chemical binding]; other site
1261557008203	chain length determination region; other site
1261557008204	substrate-Mg2+ binding site; other site
1261557008205	catalytic residues [active]
1261557008206	aspartate-rich region 1; other site
1261557008207	active site lid residues [active]
1261557008208	aspartate-rich region 2; other site
1261557008209	dihydropteroate synthase; Region: DHPS; TIGR01496
1261557008210	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
1261557008211	substrate binding pocket [chemical binding]; other site
1261557008212	dimer interface [polypeptide binding]; other site
1261557008213	inhibitor binding site; inhibition site
1261557008214	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
1261557008215	active site
1261557008216	dimerization interface [polypeptide binding]; other site
1261557008217	GTP cyclohydrolase I; Provisional; Region: folE; PRK09347
1261557008218	GTP cyclohydrolase I; Provisional; Region: PLN03044
1261557008219	active site
1261557008220	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
1261557008221	catalytic center binding site [active]
1261557008222	ATP binding site [chemical binding]; other site
1261557008223	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
1261557008224	homooctamer interface [polypeptide binding]; other site
1261557008225	active site
1261557008226	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1261557008227	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1261557008228	non-specific DNA binding site [nucleotide binding]; other site
1261557008229	salt bridge; other site
1261557008230	sequence-specific DNA binding site [nucleotide binding]; other site
1261557008231	glutathione-disulfide reductase, animal/bacterial; Region: gluta_reduc_1; TIGR01421
1261557008232	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1261557008233	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1261557008234	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1261557008235	N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145
1261557008236	Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378
1261557008237	Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968
1261557008238	Uncharacterized conserved protein [Function unknown]; Region: COG3535
1261557008239	Purine-cytosine permease and related proteins [Nucleotide transport and metabolism]; Region: CodB; COG1457
1261557008240	Na binding site [ion binding]; other site
1261557008241	Purine catabolism regulatory protein-like family; Region: PucR; pfam07905
1261557008242	Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508
1261557008243	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
1261557008244	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
1261557008245	Peptidase family U32; Region: Peptidase_U32; pfam01136
1261557008246	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
1261557008247	Peptidase family U32; Region: Peptidase_U32; pfam01136
1261557008248	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
1261557008249	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
1261557008250	Clp amino terminal domain; Region: Clp_N; pfam02861
1261557008251	Clp amino terminal domain; Region: Clp_N; pfam02861
1261557008252	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1261557008253	Walker A motif; other site
1261557008254	ATP binding site [chemical binding]; other site
1261557008255	Walker B motif; other site
1261557008256	arginine finger; other site
1261557008257	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1261557008258	Walker A motif; other site
1261557008259	ATP binding site [chemical binding]; other site
1261557008260	Walker B motif; other site
1261557008261	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
1261557008262	Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848
1261557008263	Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626
1261557008264	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
1261557008265	homodimer interface [polypeptide binding]; other site
1261557008266	substrate-cofactor binding pocket; other site
1261557008267	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1261557008268	catalytic residue [active]
1261557008269	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
1261557008270	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
1261557008271	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
1261557008272	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
1261557008273	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
1261557008274	putative active site [active]
1261557008275	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1261557008276	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1261557008277	active site
1261557008278	phosphorylation site [posttranslational modification]
1261557008279	intermolecular recognition site; other site
1261557008280	dimerization interface [polypeptide binding]; other site
1261557008281	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1261557008282	DNA binding site [nucleotide binding]
1261557008283	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1261557008284	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1261557008285	dimer interface [polypeptide binding]; other site
1261557008286	phosphorylation site [posttranslational modification]
1261557008287	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1261557008288	ATP binding site [chemical binding]; other site
1261557008289	Mg2+ binding site [ion binding]; other site
1261557008290	G-X-G motif; other site
1261557008291	seryl-tRNA synthetase; Provisional; Region: PRK05431
1261557008292	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
1261557008293	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
1261557008294	dimer interface [polypeptide binding]; other site
1261557008295	active site
1261557008296	motif 1; other site
1261557008297	motif 2; other site
1261557008298	motif 3; other site
1261557008299	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
1261557008300	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
1261557008301	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
1261557008302	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
1261557008303	active site
1261557008304	6-pyruvoyl-tetrahydropterin synthase related domain; membrane protein; Region: PTPS_related; pfam10131
1261557008305	Protein of unknown function (DUF1129); Region: DUF1129; pfam06570
1261557008306	GTP-binding protein YchF; Reviewed; Region: PRK09601
1261557008307	YchF GTPase; Region: YchF; cd01900
1261557008308	G1 box; other site
1261557008309	GTP/Mg2+ binding site [chemical binding]; other site
1261557008310	Switch I region; other site
1261557008311	G2 box; other site
1261557008312	Switch II region; other site
1261557008313	G3 box; other site
1261557008314	G4 box; other site
1261557008315	G5 box; other site
1261557008316	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
1261557008317	Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107
1261557008318	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
1261557008319	ParB-like nuclease domain; Region: ParBc; pfam02195
1261557008320	KorB domain; Region: KorB; pfam08535
1261557008321	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
1261557008322	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1261557008323	P-loop; other site
1261557008324	Magnesium ion binding site [ion binding]; other site
1261557008325	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1261557008326	Magnesium ion binding site [ion binding]; other site
1261557008327	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
1261557008328	16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107
1261557008329	Protein of unknown function (DUF3114); Region: DUF3114; pfam11311
1261557008330	myosin-cross-reactive antigen; Provisional; Region: PRK13977
1261557008331	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
1261557008332	active site
1261557008333	intersubunit interactions; other site
1261557008334	catalytic residue [active]
1261557008335	PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; pfam03829
1261557008336	PTS system, glucitol/sorbitol-specific, IIBC component; Region: EIIBC-GUT; TIGR00825
1261557008337	Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612
1261557008338	Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663
1261557008339	PTS system enzyme II sorbitol-specific factor; Region: EII-GUT; pfam03608
1261557008340	Glucitol operon activator protein (GutM); Region: GutM; pfam06923
1261557008341	HTH domain; Region: HTH_11; pfam08279
1261557008342	HTH domain; Region: HTH_11; pfam08279
1261557008343	PRD domain; Region: PRD; pfam00874
1261557008344	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
1261557008345	active site
1261557008346	P-loop; other site
1261557008347	phosphorylation site [posttranslational modification]
1261557008348	Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2; Region: PTS_EIIA_2; pfam00359
1261557008349	active site
1261557008350	phosphorylation site [posttranslational modification]
1261557008351	sorbitol-6-phosphate 2-dehydrogenase; Provisional; Region: PRK06171
1261557008352	classical (c) SDRs; Region: SDR_c; cd05233
1261557008353	NAD(P) binding site [chemical binding]; other site
1261557008354	active site
1261557008355	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
1261557008356	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
1261557008357	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
1261557008358	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
1261557008359	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
1261557008360	trmE is a tRNA modification GTPase; Region: trmE; cd04164
1261557008361	G1 box; other site
1261557008362	GTP/Mg2+ binding site [chemical binding]; other site
1261557008363	Switch I region; other site
1261557008364	G2 box; other site
1261557008365	Switch II region; other site
1261557008366	G3 box; other site
1261557008367	G4 box; other site
1261557008368	G5 box; other site
1261557008369	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
1261557008370	ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; cl00768
1261557008371	Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281
1261557008372	Malic enzyme, N-terminal domain; Region: malic; pfam00390
1261557008373	Malic enzyme, NAD binding domain; Region: Malic_M; smart00919
1261557008374	NAD(P) binding pocket [chemical binding]; other site
1261557008375	oxaloacetate decarboxylase; Provisional; Region: PRK12331
1261557008376	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
1261557008377	active site
1261557008378	catalytic residues [active]
1261557008379	metal binding site [ion binding]; metal-binding site
1261557008380	homodimer binding site [polypeptide binding]; other site
1261557008381	2'-(5''-triphosphoribosyl)-3'- dephospho-CoA:apo-citrate lyase; Reviewed; Region: citX; PRK01392
1261557008382	Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051
1261557008383	HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231
1261557008384	citrate lyase subunit gamma; Provisional; Region: PRK13253
1261557008385	Citrate lyase synthetase [Energy production and conversion]; Region: CitC; COG3053
1261557008386	Citrate lyase ligase; Region: Citrate_lyase_ligase; cd02169
1261557008387	putative active site [active]
1261557008388	(T/H)XGH motif; other site
1261557008389	Na+-transporting oxaloacetate decarboxylase beta subunit; Region: OAD_beta; pfam03977
1261557008390	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06549
1261557008391	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
1261557008392	carboxyltransferase (CT) interaction site; other site
1261557008393	biotinylation site [posttranslational modification]; other site
1261557008394	H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851
1261557008395	Citrate transporter; Region: CitMHS; pfam03600
1261557008396	Transcriptional regulators [Transcription]; Region: FadR; COG2186
1261557008397	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1261557008398	DNA-binding site [nucleotide binding]; DNA binding site
1261557008399	FCD domain; Region: FCD; pfam07729
1261557008400	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1261557008401	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1261557008402	active site
1261557008403	phosphorylation site [posttranslational modification]
1261557008404	intermolecular recognition site; other site
1261557008405	dimerization interface [polypeptide binding]; other site
1261557008406	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1261557008407	DNA binding site [nucleotide binding]
1261557008408	Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847
1261557008409	jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation.  The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414
1261557008410	G-X-X-G motif; other site
1261557008411	R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644
1261557008412	RxxxH motif; other site
1261557008413	Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706
1261557008414	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
1261557008415	ribonuclease P; Reviewed; Region: rnpA; PRK00499
1261557008416	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399