-- dump date 20140619_074143 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1155766000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 1155766000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 1155766000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1155766000004 Walker A motif; other site 1155766000005 ATP binding site [chemical binding]; other site 1155766000006 Walker B motif; other site 1155766000007 arginine finger; other site 1155766000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1155766000009 DnaA box-binding interface [nucleotide binding]; other site 1155766000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 1155766000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1155766000012 putative DNA binding surface [nucleotide binding]; other site 1155766000013 dimer interface [polypeptide binding]; other site 1155766000014 beta-clamp/clamp loader binding surface; other site 1155766000015 beta-clamp/translesion DNA polymerase binding surface; other site 1155766000016 S4 domain protein YaaA; Region: YaaA_near_RecF; TIGR02988 1155766000017 recombination protein F; Reviewed; Region: recF; PRK00064 1155766000018 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 1155766000019 Walker A/P-loop; other site 1155766000020 ATP binding site [chemical binding]; other site 1155766000021 Q-loop/lid; other site 1155766000022 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1155766000023 ABC transporter signature motif; other site 1155766000024 Walker B; other site 1155766000025 D-loop; other site 1155766000026 H-loop/switch region; other site 1155766000027 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 1155766000028 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1155766000029 Mg2+ binding site [ion binding]; other site 1155766000030 G-X-G motif; other site 1155766000031 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1155766000032 anchoring element; other site 1155766000033 dimer interface [polypeptide binding]; other site 1155766000034 ATP binding site [chemical binding]; other site 1155766000035 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1155766000036 active site 1155766000037 putative metal-binding site [ion binding]; other site 1155766000038 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1155766000039 DNA gyrase subunit A; Validated; Region: PRK05560 1155766000040 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1155766000041 CAP-like domain; other site 1155766000042 active site 1155766000043 primary dimer interface [polypeptide binding]; other site 1155766000044 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1155766000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1155766000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1155766000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1155766000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1155766000049 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 1155766000050 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1155766000051 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1155766000052 dimer interface [polypeptide binding]; other site 1155766000053 ssDNA binding site [nucleotide binding]; other site 1155766000054 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1155766000055 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 1155766000056 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 1155766000057 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 1155766000058 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1155766000059 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 1155766000060 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1155766000061 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 1155766000062 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1155766000063 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 1155766000064 DHH family; Region: DHH; pfam01368 1155766000065 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 1155766000066 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1155766000067 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1155766000068 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1155766000069 replicative DNA helicase; Provisional; Region: PRK05748 1155766000070 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1155766000071 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1155766000072 Walker A motif; other site 1155766000073 ATP binding site [chemical binding]; other site 1155766000074 Walker B motif; other site 1155766000075 DNA binding loops [nucleotide binding] 1155766000076 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1155766000077 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1155766000078 GDP-binding site [chemical binding]; other site 1155766000079 ACT binding site; other site 1155766000080 IMP binding site; other site 1155766000081 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1155766000082 Helix-turn-helix domain; Region: HTH_28; pfam13518 1155766000083 Helix-turn-helix domain; Region: HTH_28; pfam13518 1155766000084 Winged helix-turn helix; Region: HTH_29; pfam13551 1155766000085 Homeodomain-like domain; Region: HTH_32; pfam13565 1155766000086 putative transposase OrfB; Reviewed; Region: PHA02517 1155766000087 HTH-like domain; Region: HTH_21; pfam13276 1155766000088 Integrase core domain; Region: rve; pfam00665 1155766000089 Integrase core domain; Region: rve_2; pfam13333 1155766000090 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 1155766000091 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1155766000092 EDD domain protein, DegV family; Region: DegV; TIGR00762 1155766000093 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1155766000094 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 1155766000095 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1155766000096 Walker A/P-loop; other site 1155766000097 ATP binding site [chemical binding]; other site 1155766000098 Q-loop/lid; other site 1155766000099 ABC transporter signature motif; other site 1155766000100 Walker B; other site 1155766000101 D-loop; other site 1155766000102 H-loop/switch region; other site 1155766000103 ABC transporter; Region: ABC_tran_2; pfam12848 1155766000104 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1155766000105 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 1155766000106 pyruvate oxidase; Region: pyruv_oxi_spxB; TIGR02720 1155766000107 PYR/PP interface [polypeptide binding]; other site 1155766000108 dimer interface [polypeptide binding]; other site 1155766000109 tetramer interface [polypeptide binding]; other site 1155766000110 TPP binding site [chemical binding]; other site 1155766000111 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1155766000112 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 1155766000113 TPP-binding site [chemical binding]; other site 1155766000114 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 1155766000115 ZIP Zinc transporter; Region: Zip; pfam02535 1155766000116 Protein of unknown function (DUF1211); Region: DUF1211; cl01421 1155766000117 VanZ like family; Region: VanZ; pfam04892 1155766000118 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1155766000119 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1155766000120 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 1155766000121 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1155766000122 motif II; other site 1155766000123 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1155766000124 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1155766000125 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1155766000126 6-phospho-beta-galactosidase; Provisional; Region: PRK13511 1155766000127 beta-galactosidase; Region: BGL; TIGR03356 1155766000128 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 1155766000129 methionine cluster; other site 1155766000130 active site 1155766000131 phosphorylation site [posttranslational modification] 1155766000132 metal binding site [ion binding]; metal-binding site 1155766000133 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; cl17295 1155766000134 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 1155766000135 PTS_IIB_lactose: subunit IIB of enzyme II (EII) of the lactose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS) found in Firmicutes as well as Actinobacteria. In this system, EII is a lactose-specific permease with two...; Region: PTS_IIB_lactose; cd05565 1155766000136 active site 1155766000137 P-loop; other site 1155766000138 phosphorylation site [posttranslational modification] 1155766000139 Glycosyl hydrolase family 53; Region: Glyco_hydro_53; cl06672 1155766000140 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1155766000141 MULE transposase domain; Region: MULE; pfam10551 1155766000142 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1155766000143 AAA domain; Region: AAA_21; pfam13304 1155766000144 Walker A/P-loop; other site 1155766000145 ATP binding site [chemical binding]; other site 1155766000146 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 1155766000147 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 1155766000148 putative active site [active] 1155766000149 putative metal-binding site [ion binding]; other site 1155766000150 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 1155766000151 Part of AAA domain; Region: AAA_19; pfam13245 1155766000152 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1155766000153 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 1155766000154 Family description; Region: UvrD_C_2; pfam13538 1155766000155 Bacterial protein of unknown function (DUF961); Region: DUF961; pfam06125 1155766000156 Bacterial protein of unknown function (DUF961); Region: DUF961; pfam06125 1155766000157 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1155766000158 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1155766000159 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1155766000160 non-specific DNA binding site [nucleotide binding]; other site 1155766000161 salt bridge; other site 1155766000162 sequence-specific DNA binding site [nucleotide binding]; other site 1155766000163 Replication initiation factor; Region: Rep_trans; pfam02486 1155766000164 Abortive infection C-terminus; Region: Abi_C; pfam14355 1155766000165 Antirestriction protein (ArdA); Region: ArdA; pfam07275 1155766000166 TcpE family; Region: TcpE; pfam12648 1155766000167 AAA-like domain; Region: AAA_10; pfam12846 1155766000168 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 1155766000169 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1155766000170 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1155766000171 catalytic residue [active] 1155766000172 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1155766000173 NlpC/P60 family; Region: NLPC_P60; pfam00877 1155766000174 Conjugative transposon protein TcpC; Region: TpcC; pfam12642 1155766000175 Elongation factor Tu GTP binding domain; Region: GTP_EFTU; pfam00009 1155766000176 Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168 1155766000177 G1 box; other site 1155766000178 putative GEF interaction site [polypeptide binding]; other site 1155766000179 GTP/Mg2+ binding site [chemical binding]; other site 1155766000180 Switch I region; other site 1155766000181 G2 box; other site 1155766000182 G3 box; other site 1155766000183 Switch II region; other site 1155766000184 G4 box; other site 1155766000185 G5 box; other site 1155766000186 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 1155766000187 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1155766000188 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1155766000189 folate binding site [chemical binding]; other site 1155766000190 NADP+ binding site [chemical binding]; other site 1155766000191 Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480 1155766000192 Tet_II: This subfamily represents domain II of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to domain II of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome...; Region: Tet_II; cd03690 1155766000193 EF-G_domain IV_RPP domain is a part of bacterial ribosomal protected proteins (RPP) family. RPPs such as tetracycline resistance proteins Tet(M) and Tet(O) mediate tetracycline resistance in both gram-positive and -negative species. Tetracyclines inhibit...; Region: Tet_like_IV; cd01684 1155766000194 Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711 1155766000195 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1155766000196 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1155766000197 non-specific DNA binding site [nucleotide binding]; other site 1155766000198 salt bridge; other site 1155766000199 sequence-specific DNA binding site [nucleotide binding]; other site 1155766000200 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1155766000201 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1155766000202 DNA binding residues [nucleotide binding] 1155766000203 Helix-turn-helix domain; Region: HTH_16; pfam12645 1155766000204 Domain of unknown function (DUF3173); Region: DUF3173; pfam11372 1155766000205 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1155766000206 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 1155766000207 Int/Topo IB signature motif; other site 1155766000208 GMP synthase; Reviewed; Region: guaA; PRK00074 1155766000209 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1155766000210 AMP/PPi binding site [chemical binding]; other site 1155766000211 candidate oxyanion hole; other site 1155766000212 catalytic triad [active] 1155766000213 potential glutamine specificity residues [chemical binding]; other site 1155766000214 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1155766000215 ATP Binding subdomain [chemical binding]; other site 1155766000216 Dimerization subdomain; other site 1155766000217 pantothenate kinase; Provisional; Region: PRK05439 1155766000218 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 1155766000219 ATP-binding site [chemical binding]; other site 1155766000220 CoA-binding site [chemical binding]; other site 1155766000221 Mg2+-binding site [ion binding]; other site 1155766000222 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1155766000223 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1155766000224 S-adenosylmethionine binding site [chemical binding]; other site 1155766000225 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1155766000226 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1155766000227 DNA binding site [nucleotide binding] 1155766000228 domain linker motif; other site 1155766000229 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1155766000230 dimerization interface [polypeptide binding]; other site 1155766000231 ligand binding site [chemical binding]; other site 1155766000232 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 1155766000233 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1155766000234 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1155766000235 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 1155766000236 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 1155766000237 intersubunit interface [polypeptide binding]; other site 1155766000238 active site 1155766000239 catalytic residue [active] 1155766000240 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 1155766000241 active site 1155766000242 catalytic motif [active] 1155766000243 Zn binding site [ion binding]; other site 1155766000244 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 1155766000245 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 1155766000246 ligand binding site [chemical binding]; other site 1155766000247 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 1155766000248 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1155766000249 Walker A/P-loop; other site 1155766000250 ATP binding site [chemical binding]; other site 1155766000251 Q-loop/lid; other site 1155766000252 ABC transporter signature motif; other site 1155766000253 Walker B; other site 1155766000254 D-loop; other site 1155766000255 H-loop/switch region; other site 1155766000256 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1155766000257 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1155766000258 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1155766000259 TM-ABC transporter signature motif; other site 1155766000260 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1155766000261 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1155766000262 TM-ABC transporter signature motif; other site 1155766000263 phosphopentomutase; Provisional; Region: PRK05362 1155766000264 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 1155766000265 purine nucleoside phosphorylase; Provisional; Region: PRK08202 1155766000266 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 1155766000267 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 1155766000268 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1155766000269 catalytic core [active] 1155766000270 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1155766000271 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1155766000272 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1155766000273 catalytic residues [active] 1155766000274 catalytic nucleophile [active] 1155766000275 Presynaptic Site I dimer interface [polypeptide binding]; other site 1155766000276 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1155766000277 Synaptic Flat tetramer interface [polypeptide binding]; other site 1155766000278 Synaptic Site I dimer interface [polypeptide binding]; other site 1155766000279 DNA binding site [nucleotide binding] 1155766000280 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 1155766000281 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1155766000282 active site 1155766000283 dimer interface [polypeptide binding]; other site 1155766000284 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1155766000285 S17 interaction site [polypeptide binding]; other site 1155766000286 S8 interaction site; other site 1155766000287 16S rRNA interaction site [nucleotide binding]; other site 1155766000288 streptomycin interaction site [chemical binding]; other site 1155766000289 23S rRNA interaction site [nucleotide binding]; other site 1155766000290 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1155766000291 30S ribosomal protein S7; Validated; Region: PRK05302 1155766000292 elongation factor G; Reviewed; Region: PRK00007 1155766000293 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1155766000294 G1 box; other site 1155766000295 putative GEF interaction site [polypeptide binding]; other site 1155766000296 GTP/Mg2+ binding site [chemical binding]; other site 1155766000297 Switch I region; other site 1155766000298 G2 box; other site 1155766000299 G3 box; other site 1155766000300 Switch II region; other site 1155766000301 G4 box; other site 1155766000302 G5 box; other site 1155766000303 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1155766000304 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1155766000305 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1155766000306 elongation factor Tu; Reviewed; Region: PRK00049 1155766000307 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1155766000308 G1 box; other site 1155766000309 GEF interaction site [polypeptide binding]; other site 1155766000310 GTP/Mg2+ binding site [chemical binding]; other site 1155766000311 Switch I region; other site 1155766000312 G2 box; other site 1155766000313 G3 box; other site 1155766000314 Switch II region; other site 1155766000315 G4 box; other site 1155766000316 G5 box; other site 1155766000317 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1155766000318 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1155766000319 Antibiotic Binding Site [chemical binding]; other site 1155766000320 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 1155766000321 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 1155766000322 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 1155766000323 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 1155766000324 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1155766000325 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1155766000326 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1155766000327 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 1155766000328 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1155766000329 putative translocon binding site; other site 1155766000330 protein-rRNA interface [nucleotide binding]; other site 1155766000331 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 1155766000332 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1155766000333 G-X-X-G motif; other site 1155766000334 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1155766000335 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1155766000336 23S rRNA interface [nucleotide binding]; other site 1155766000337 5S rRNA interface [nucleotide binding]; other site 1155766000338 putative antibiotic binding site [chemical binding]; other site 1155766000339 L25 interface [polypeptide binding]; other site 1155766000340 L27 interface [polypeptide binding]; other site 1155766000341 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1155766000342 23S rRNA interface [nucleotide binding]; other site 1155766000343 putative translocon interaction site; other site 1155766000344 signal recognition particle (SRP54) interaction site; other site 1155766000345 L23 interface [polypeptide binding]; other site 1155766000346 trigger factor interaction site; other site 1155766000347 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 1155766000348 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 1155766000349 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1155766000350 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1155766000351 RNA binding site [nucleotide binding]; other site 1155766000352 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1155766000353 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1155766000354 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1155766000355 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 1155766000356 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 1155766000357 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1155766000358 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1155766000359 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1155766000360 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1155766000361 5S rRNA interface [nucleotide binding]; other site 1155766000362 L27 interface [polypeptide binding]; other site 1155766000363 23S rRNA interface [nucleotide binding]; other site 1155766000364 L5 interface [polypeptide binding]; other site 1155766000365 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 1155766000366 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1155766000367 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1155766000368 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 1155766000369 23S rRNA binding site [nucleotide binding]; other site 1155766000370 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1155766000371 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1155766000372 SecY translocase; Region: SecY; pfam00344 1155766000373 adenylate kinase; Reviewed; Region: adk; PRK00279 1155766000374 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1155766000375 AMP-binding site [chemical binding]; other site 1155766000376 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1155766000377 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1155766000378 rRNA binding site [nucleotide binding]; other site 1155766000379 predicted 30S ribosome binding site; other site 1155766000380 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 1155766000381 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 1155766000382 30S ribosomal protein S13; Region: bact_S13; TIGR03631 1155766000383 30S ribosomal protein S11; Validated; Region: PRK05309 1155766000384 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1155766000385 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1155766000386 alphaNTD homodimer interface [polypeptide binding]; other site 1155766000387 alphaNTD - beta interaction site [polypeptide binding]; other site 1155766000388 alphaNTD - beta' interaction site [polypeptide binding]; other site 1155766000389 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1155766000390 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 1155766000391 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635 1155766000392 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1155766000393 Walker A/P-loop; other site 1155766000394 ATP binding site [chemical binding]; other site 1155766000395 Q-loop/lid; other site 1155766000396 ABC transporter signature motif; other site 1155766000397 Walker B; other site 1155766000398 D-loop; other site 1155766000399 H-loop/switch region; other site 1155766000400 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13634 1155766000401 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1155766000402 Walker A/P-loop; other site 1155766000403 ATP binding site [chemical binding]; other site 1155766000404 Q-loop/lid; other site 1155766000405 ABC transporter signature motif; other site 1155766000406 Walker B; other site 1155766000407 D-loop; other site 1155766000408 H-loop/switch region; other site 1155766000409 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1155766000410 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 1155766000411 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1155766000412 dimerization interface 3.5A [polypeptide binding]; other site 1155766000413 active site 1155766000414 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 1155766000415 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1155766000416 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 1155766000417 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 1155766000418 DAK2 domain; Region: Dak2; pfam02734 1155766000419 ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020 1155766000420 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 1155766000421 Y-family of DNA polymerases; Region: PolY; cl12025 1155766000422 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1155766000423 generic binding surface II; other site 1155766000424 ssDNA binding site; other site 1155766000425 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1155766000426 ATP binding site [chemical binding]; other site 1155766000427 putative Mg++ binding site [ion binding]; other site 1155766000428 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1155766000429 nucleotide binding region [chemical binding]; other site 1155766000430 ATP-binding site [chemical binding]; other site 1155766000431 putative phosphate acyltransferase; Provisional; Region: PRK05331 1155766000432 acyl carrier protein; Provisional; Region: acpP; PRK00982 1155766000433 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1155766000434 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1155766000435 Walker A/P-loop; other site 1155766000436 ATP binding site [chemical binding]; other site 1155766000437 Q-loop/lid; other site 1155766000438 ABC transporter signature motif; other site 1155766000439 Walker B; other site 1155766000440 D-loop; other site 1155766000441 H-loop/switch region; other site 1155766000442 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1155766000443 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1155766000444 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1155766000445 Walker A/P-loop; other site 1155766000446 ATP binding site [chemical binding]; other site 1155766000447 Q-loop/lid; other site 1155766000448 ABC transporter signature motif; other site 1155766000449 Walker B; other site 1155766000450 D-loop; other site 1155766000451 H-loop/switch region; other site 1155766000452 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 1155766000453 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1155766000454 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1155766000455 dimer interface [polypeptide binding]; other site 1155766000456 conserved gate region; other site 1155766000457 putative PBP binding loops; other site 1155766000458 ABC-ATPase subunit interface; other site 1155766000459 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1155766000460 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1155766000461 putative PBP binding loops; other site 1155766000462 dimer interface [polypeptide binding]; other site 1155766000463 ABC-ATPase subunit interface; other site 1155766000464 The substrate binding component of an ABC-type lactococcal OppA-like transport system contains; Region: PBP2_Lactococcal_OppA_like; cd08510 1155766000465 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1155766000466 peptide binding site [polypeptide binding]; other site 1155766000467 ribonuclease III; Reviewed; Region: rnc; PRK00102 1155766000468 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1155766000469 dimerization interface [polypeptide binding]; other site 1155766000470 active site 1155766000471 metal binding site [ion binding]; metal-binding site 1155766000472 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1155766000473 dsRNA binding site [nucleotide binding]; other site 1155766000474 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1155766000475 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1155766000476 Walker A/P-loop; other site 1155766000477 ATP binding site [chemical binding]; other site 1155766000478 Q-loop/lid; other site 1155766000479 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 1155766000480 Nucleoporin complex subunit 54; Region: Nup54; pfam13874 1155766000481 Protein of unknown function (DUF2968); Region: DUF2968; pfam11180 1155766000482 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1155766000483 ABC transporter signature motif; other site 1155766000484 Walker B; other site 1155766000485 D-loop; other site 1155766000486 H-loop/switch region; other site 1155766000487 sugar phosphate phosphatase; Provisional; Region: PRK10513 1155766000488 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1155766000489 active site 1155766000490 motif I; other site 1155766000491 motif II; other site 1155766000492 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1155766000493 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 1155766000494 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 1155766000495 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1155766000496 P loop; other site 1155766000497 GTP binding site [chemical binding]; other site 1155766000498 Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352 1155766000499 bifunctional glutamate--cysteine ligase/glutathione synthetase; Provisional; Region: PRK02471 1155766000500 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1155766000501 Protein of unknown function (DUF1694); Region: DUF1694; pfam07997 1155766000502 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1155766000503 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1155766000504 ABC-ATPase subunit interface; other site 1155766000505 dimer interface [polypeptide binding]; other site 1155766000506 putative PBP binding regions; other site 1155766000507 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1155766000508 ABC-ATPase subunit interface; other site 1155766000509 dimer interface [polypeptide binding]; other site 1155766000510 putative PBP binding regions; other site 1155766000511 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 1155766000512 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1155766000513 Walker A/P-loop; other site 1155766000514 ATP binding site [chemical binding]; other site 1155766000515 Q-loop/lid; other site 1155766000516 ABC transporter signature motif; other site 1155766000517 Walker B; other site 1155766000518 D-loop; other site 1155766000519 H-loop/switch region; other site 1155766000520 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 1155766000521 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 1155766000522 putative ligand binding residues [chemical binding]; other site 1155766000523 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4918 1155766000524 putative phosphoesterase; Region: acc_ester; TIGR03729 1155766000525 WxL domain surface cell wall-binding; Region: WxL; pfam13731 1155766000526 legume lectins; Region: lectin_L-type; cd01951 1155766000527 homotetramer interaction site [polypeptide binding]; other site 1155766000528 homodimer interaction site [polypeptide binding]; other site 1155766000529 carbohydrate binding site [chemical binding]; other site 1155766000530 metal binding site [ion binding]; metal-binding site 1155766000531 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 1155766000532 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 1155766000533 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 1155766000534 Mga helix-turn-helix domain; Region: Mga; pfam05043 1155766000535 potential frameshift: common BLAST hit: gi|29377271|ref|NP_816425.1| ISEf1, transposase 1155766000536 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1155766000537 MULE transposase domain; Region: MULE; pfam10551 1155766000538 potential frameshift: common BLAST hit: gi|320152782|ref|YP_004172605.1| integrase 1155766000539 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1155766000540 Integrase core domain; Region: rve; pfam00665 1155766000541 Integrase core domain; Region: rve_3; cl15866 1155766000542 Helix-turn-helix domain; Region: HTH_38; pfam13936 1155766000543 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 1155766000544 amphipathic channel; other site 1155766000545 Asn-Pro-Ala signature motifs; other site 1155766000546 LrgA family; Region: LrgA; pfam03788 1155766000547 LrgB-like family; Region: LrgB; pfam04172 1155766000548 Mga helix-turn-helix domain; Region: Mga; pfam05043 1155766000549 Protein of unknown function (DUF2829); Region: DUF2829; pfam11195 1155766000550 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK06550 1155766000551 classical (c) SDRs; Region: SDR_c; cd05233 1155766000552 NAD(P) binding site [chemical binding]; other site 1155766000553 active site 1155766000554 QueT transporter; Region: QueT; pfam06177 1155766000555 BioY family; Region: BioY; pfam02632 1155766000556 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1155766000557 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1155766000558 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1155766000559 RNA binding surface [nucleotide binding]; other site 1155766000560 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927 1155766000561 A new structural DNA glycosylase containing HEAT-like repeats; Region: AlkD_like_1; cd07064 1155766000562 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 1155766000563 active site 1155766000564 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1155766000565 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1155766000566 active site 1155766000567 motif I; other site 1155766000568 motif II; other site 1155766000569 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 1155766000570 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 1155766000571 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1155766000572 putative active site [active] 1155766000573 metal binding site [ion binding]; metal-binding site 1155766000574 homodimer binding site [polypeptide binding]; other site 1155766000575 Protein of unknown function (DUF964); Region: DUF964; cl01483 1155766000576 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 1155766000577 MutS domain I; Region: MutS_I; pfam01624 1155766000578 MutS domain II; Region: MutS_II; pfam05188 1155766000579 MutS domain III; Region: MutS_III; pfam05192 1155766000580 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 1155766000581 Walker A/P-loop; other site 1155766000582 ATP binding site [chemical binding]; other site 1155766000583 Q-loop/lid; other site 1155766000584 ABC transporter signature motif; other site 1155766000585 Walker B; other site 1155766000586 D-loop; other site 1155766000587 H-loop/switch region; other site 1155766000588 DNA mismatch repair enzyme (predicted ATPase) [DNA replication, recombination, and repair]; Region: MutL; COG0323 1155766000589 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1155766000590 ATP binding site [chemical binding]; other site 1155766000591 Mg2+ binding site [ion binding]; other site 1155766000592 G-X-G motif; other site 1155766000593 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 1155766000594 ATP binding site [chemical binding]; other site 1155766000595 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 1155766000596 Maf-like protein; Region: Maf; pfam02545 1155766000597 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1155766000598 active site 1155766000599 dimer interface [polypeptide binding]; other site 1155766000600 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 1155766000601 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1155766000602 active site turn [active] 1155766000603 phosphorylation site [posttranslational modification] 1155766000604 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1155766000605 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 1155766000606 HPr interaction site; other site 1155766000607 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1155766000608 active site 1155766000609 phosphorylation site [posttranslational modification] 1155766000610 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 1155766000611 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1155766000612 DNA-binding site [nucleotide binding]; DNA binding site 1155766000613 UTRA domain; Region: UTRA; pfam07702 1155766000614 methionine sulfoxide reductase B; Provisional; Region: PRK00222 1155766000615 SelR domain; Region: SelR; pfam01641 1155766000616 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 1155766000617 RuvA N terminal domain; Region: RuvA_N; pfam01330 1155766000618 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 1155766000619 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1155766000620 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1155766000621 Walker A motif; other site 1155766000622 ATP binding site [chemical binding]; other site 1155766000623 Walker B motif; other site 1155766000624 arginine finger; other site 1155766000625 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1155766000626 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 1155766000627 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1155766000628 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1155766000629 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1155766000630 active site 1155766000631 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1155766000632 MULE transposase domain; Region: MULE; pfam10551 1155766000633 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 1155766000634 Protein of unknown function (DUF1211); Region: DUF1211; cl01421 1155766000635 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1155766000636 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 1155766000637 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1155766000638 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1155766000639 Walker A/P-loop; other site 1155766000640 ATP binding site [chemical binding]; other site 1155766000641 Q-loop/lid; other site 1155766000642 ABC transporter signature motif; other site 1155766000643 Walker B; other site 1155766000644 D-loop; other site 1155766000645 H-loop/switch region; other site 1155766000646 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1155766000647 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1155766000648 substrate binding pocket [chemical binding]; other site 1155766000649 membrane-bound complex binding site; other site 1155766000650 hinge residues; other site 1155766000651 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1155766000652 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1155766000653 dimer interface [polypeptide binding]; other site 1155766000654 conserved gate region; other site 1155766000655 putative PBP binding loops; other site 1155766000656 ABC-ATPase subunit interface; other site 1155766000657 NAD-dependent deacetylase; Provisional; Region: PRK00481 1155766000658 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 1155766000659 maltose O-acetyltransferase; Provisional; Region: PRK10092 1155766000660 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 1155766000661 active site 1155766000662 substrate binding site [chemical binding]; other site 1155766000663 trimer interface [polypeptide binding]; other site 1155766000664 CoA binding site [chemical binding]; other site 1155766000665 hypothetical protein; Provisional; Region: PRK07248 1155766000666 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 1155766000667 HTH domain; Region: HTH_11; pfam08279 1155766000668 3H domain; Region: 3H; pfam02829 1155766000669 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1155766000670 active site 1155766000671 catalytic residues [active] 1155766000672 metal binding site [ion binding]; metal-binding site 1155766000673 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 1155766000674 16S/18S rRNA binding site [nucleotide binding]; other site 1155766000675 S13e-L30e interaction site [polypeptide binding]; other site 1155766000676 25S rRNA binding site [nucleotide binding]; other site 1155766000677 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 1155766000678 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 1155766000679 RNase E interface [polypeptide binding]; other site 1155766000680 trimer interface [polypeptide binding]; other site 1155766000681 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 1155766000682 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 1155766000683 RNase E interface [polypeptide binding]; other site 1155766000684 trimer interface [polypeptide binding]; other site 1155766000685 active site 1155766000686 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 1155766000687 putative nucleic acid binding region [nucleotide binding]; other site 1155766000688 G-X-X-G motif; other site 1155766000689 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1155766000690 RNA binding site [nucleotide binding]; other site 1155766000691 domain interface; other site 1155766000692 K+ potassium transporter; Region: K_trans; cl15781 1155766000693 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1155766000694 Domain of unknown function DUF21; Region: DUF21; pfam01595 1155766000695 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1155766000696 Transporter associated domain; Region: CorC_HlyC; smart01091 1155766000697 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1155766000698 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 1155766000699 Staphylococcal protein of unknown function (DUF960); Region: DUF960; pfam06124 1155766000700 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 1155766000701 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 1155766000702 5S rRNA interface [nucleotide binding]; other site 1155766000703 CTC domain interface [polypeptide binding]; other site 1155766000704 L16 interface [polypeptide binding]; other site 1155766000705 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1155766000706 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 1155766000707 active site 1155766000708 uracil binding [chemical binding]; other site 1155766000709 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 1155766000710 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1155766000711 motif II; other site 1155766000712 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 1155766000713 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 1155766000714 Sugar specificity; other site 1155766000715 Pyrimidine base specificity; other site 1155766000716 ATP-binding site [chemical binding]; other site 1155766000717 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1155766000718 Helix-turn-helix domain; Region: HTH_28; pfam13518 1155766000719 Helix-turn-helix domain; Region: HTH_28; pfam13518 1155766000720 Winged helix-turn helix; Region: HTH_29; pfam13551 1155766000721 Homeodomain-like domain; Region: HTH_32; pfam13565 1155766000722 putative transposase OrfB; Reviewed; Region: PHA02517 1155766000723 HTH-like domain; Region: HTH_21; pfam13276 1155766000724 Integrase core domain; Region: rve; pfam00665 1155766000725 Integrase core domain; Region: rve_2; pfam13333 1155766000726 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1155766000727 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1155766000728 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1155766000729 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1155766000730 hypothetical protein; Validated; Region: PRK00124 1155766000731 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 1155766000732 ABC1 family; Region: ABC1; cl17513 1155766000733 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 1155766000734 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1155766000735 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 1155766000736 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 1155766000737 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1155766000738 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1155766000739 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1155766000740 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1155766000741 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1155766000742 ATP binding site [chemical binding]; other site 1155766000743 Mg++ binding site [ion binding]; other site 1155766000744 motif III; other site 1155766000745 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1155766000746 nucleotide binding region [chemical binding]; other site 1155766000747 ATP-binding site [chemical binding]; other site 1155766000748 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 1155766000749 alanine racemase; Reviewed; Region: alr; PRK00053 1155766000750 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 1155766000751 active site 1155766000752 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1155766000753 dimer interface [polypeptide binding]; other site 1155766000754 substrate binding site [chemical binding]; other site 1155766000755 catalytic residues [active] 1155766000756 PemK-like protein; Region: PemK; pfam02452 1155766000757 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 1155766000758 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1155766000759 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 1155766000760 putative NAD(P) binding site [chemical binding]; other site 1155766000761 Predicted membrane protein [Function unknown]; Region: COG1511 1155766000762 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1155766000763 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 1155766000764 Amino acid permease; Region: AA_permease_2; pfam13520 1155766000765 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 1155766000766 Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389 1155766000767 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 1155766000768 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1155766000769 dimer interface [polypeptide binding]; other site 1155766000770 conserved gate region; other site 1155766000771 putative PBP binding loops; other site 1155766000772 ABC-ATPase subunit interface; other site 1155766000773 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 1155766000774 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 1155766000775 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1155766000776 dimer interface [polypeptide binding]; other site 1155766000777 conserved gate region; other site 1155766000778 putative PBP binding loops; other site 1155766000779 ABC-ATPase subunit interface; other site 1155766000780 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 1155766000781 glycine betaine/L-proline transport ATP binding subunit; Region: proV; TIGR01186 1155766000782 Walker A/P-loop; other site 1155766000783 ATP binding site [chemical binding]; other site 1155766000784 Q-loop/lid; other site 1155766000785 ABC transporter signature motif; other site 1155766000786 Walker B; other site 1155766000787 D-loop; other site 1155766000788 H-loop/switch region; other site 1155766000789 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 1155766000790 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 1155766000791 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 1155766000792 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 1155766000793 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1155766000794 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1155766000795 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1155766000796 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1155766000797 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1155766000798 Protein of unknown function (DUF975); Region: DUF975; cl10504 1155766000799 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 1155766000800 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 1155766000801 Preprotein translocase subunit; Region: YajC; cl00806 1155766000802 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 1155766000803 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 1155766000804 putative catalytic cysteine [active] 1155766000805 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 1155766000806 putative active site [active] 1155766000807 metal binding site [ion binding]; metal-binding site 1155766000808 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 1155766000809 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 1155766000810 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 1155766000811 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 1155766000812 DctM-like transporters; Region: DctM; pfam06808 1155766000813 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 1155766000814 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1155766000815 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1155766000816 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1155766000817 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1155766000818 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1155766000819 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1155766000820 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1155766000821 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1155766000822 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 1155766000823 N- and C-terminal domain interface [polypeptide binding]; other site 1155766000824 rhamnulokinase; Region: rhamnulo_kin; TIGR02627 1155766000825 active site 1155766000826 putative catalytic site [active] 1155766000827 metal binding site [ion binding]; metal-binding site 1155766000828 ATP binding site [chemical binding]; other site 1155766000829 carbohydrate binding site [chemical binding]; other site 1155766000830 L-rhamnose isomerase; Provisional; Region: PRK01076 1155766000831 Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900 1155766000832 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 1155766000833 intersubunit interface [polypeptide binding]; other site 1155766000834 active site 1155766000835 Zn2+ binding site [ion binding]; other site 1155766000836 Domain of unknown function (DUF718); Region: DUF718; cl01281 1155766000837 L-1,2-propanediol oxidoreductase; Provisional; Region: PRK10624 1155766000838 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 1155766000839 dimer interface [polypeptide binding]; other site 1155766000840 active site 1155766000841 metal binding site [ion binding]; metal-binding site 1155766000842 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1155766000843 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1155766000844 Bacterial transcriptional regulator; Region: IclR; pfam01614 1155766000845 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 1155766000846 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 1155766000847 active site 1155766000848 intersubunit interface [polypeptide binding]; other site 1155766000849 catalytic residue [active] 1155766000850 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1155766000851 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1155766000852 substrate binding site [chemical binding]; other site 1155766000853 ATP binding site [chemical binding]; other site 1155766000854 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 1155766000855 gluconate 5-dehydrogenase; Provisional; Region: PRK07097 1155766000856 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 1155766000857 NADP binding site [chemical binding]; other site 1155766000858 homodimer interface [polypeptide binding]; other site 1155766000859 active site 1155766000860 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 1155766000861 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 1155766000862 homotetramer interface [polypeptide binding]; other site 1155766000863 FMN binding site [chemical binding]; other site 1155766000864 homodimer contacts [polypeptide binding]; other site 1155766000865 putative active site [active] 1155766000866 putative substrate binding site [chemical binding]; other site 1155766000867 phosphomevalonate kinase, ERG8-type, Gram-positive branch; Region: Pmev_kin_Gr_pos; TIGR01220 1155766000868 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1155766000869 diphosphomevalonate decarboxylase; Region: mevDPdecarb; TIGR01240 1155766000870 diphosphomevalonate decarboxylase; Region: PLN02407 1155766000871 mevalonate kinase; Region: mevalon_kin; TIGR00549 1155766000872 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1155766000873 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 1155766000874 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 1155766000875 Substrate-binding site [chemical binding]; other site 1155766000876 Substrate specificity [chemical binding]; other site 1155766000877 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 1155766000878 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 1155766000879 Cl binding site [ion binding]; other site 1155766000880 oligomer interface [polypeptide binding]; other site 1155766000881 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1155766000882 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1155766000883 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 1155766000884 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1155766000885 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1155766000886 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 1155766000887 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1155766000888 23S rRNA binding site [nucleotide binding]; other site 1155766000889 L21 binding site [polypeptide binding]; other site 1155766000890 L13 binding site [polypeptide binding]; other site 1155766000891 Citrate transporter; Region: CitMHS; pfam03600 1155766000892 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 1155766000893 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 1155766000894 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 1155766000895 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1155766000896 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1155766000897 DNA-binding site [nucleotide binding]; DNA binding site 1155766000898 FCD domain; Region: FCD; pfam07729 1155766000899 NosL; Region: NosL; cl01769 1155766000900 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1155766000901 active site 1155766000902 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 1155766000903 putative substrate binding site [chemical binding]; other site 1155766000904 putative ATP binding site [chemical binding]; other site 1155766000905 dipeptidase PepV; Reviewed; Region: PRK07318 1155766000906 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 1155766000907 active site 1155766000908 metal binding site [ion binding]; metal-binding site 1155766000909 glycosyltransferase, TIGR04182 family; Region: glyco_TIGR04182 1155766000910 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 1155766000911 Ligand binding site; other site 1155766000912 Putative Catalytic site; other site 1155766000913 DXD motif; other site 1155766000914 Predicted small secreted protein [Function unknown]; Region: COG5584 1155766000915 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 1155766000916 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 1155766000917 oligomer interface [polypeptide binding]; other site 1155766000918 active site 1155766000919 metal binding site [ion binding]; metal-binding site 1155766000920 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1155766000921 catalytic residues [active] 1155766000922 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1155766000923 Ligand Binding Site [chemical binding]; other site 1155766000924 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1155766000925 putative tRNA-binding site [nucleotide binding]; other site 1155766000926 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1155766000927 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1155766000928 protein binding site [polypeptide binding]; other site 1155766000929 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 1155766000930 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807 1155766000931 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 1155766000932 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 1155766000933 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 1155766000934 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1155766000935 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1155766000936 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 1155766000937 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 1155766000938 Enterocin A Immunity; Region: EntA_Immun; pfam08951 1155766000939 Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225 1155766000940 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1155766000941 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 1155766000942 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1155766000943 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1155766000944 Walker A/P-loop; other site 1155766000945 ATP binding site [chemical binding]; other site 1155766000946 Q-loop/lid; other site 1155766000947 ABC transporter signature motif; other site 1155766000948 Walker B; other site 1155766000949 D-loop; other site 1155766000950 H-loop/switch region; other site 1155766000951 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4652 1155766000952 Bacteriocin (Lactococcin_972); Region: Lactococcin_972; cl09891 1155766000953 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1155766000954 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1155766000955 non-specific DNA binding site [nucleotide binding]; other site 1155766000956 salt bridge; other site 1155766000957 sequence-specific DNA binding site [nucleotide binding]; other site 1155766000958 HTH domain; Region: HTH_11; cl17392 1155766000959 Initiator Replication protein; Region: Rep_3; pfam01051 1155766000960 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 1155766000961 Bacterial mobilisation protein (MobC); Region: MobC; pfam05713 1155766000962 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1155766000963 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 1155766000964 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1155766000965 Coenzyme A binding pocket [chemical binding]; other site 1155766000966 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 1155766000967 active site 1155766000968 Staphylococcal protein of unknown function (DUF960); Region: DUF960; pfam06124 1155766000969 Protein of unknown function (DUF1643); Region: DUF1643; cl01787 1155766000970 Mor transcription activator family; Region: Mor; cl02360 1155766000971 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1155766000972 Helix-turn-helix domain; Region: HTH_38; pfam13936 1155766000973 Integrase core domain; Region: rve; pfam00665 1155766000974 Integrase core domain; Region: rve_3; cl15866 1155766000975 Sulfatase; Region: Sulfatase; pfam00884 1155766000976 serine/threonine transporter SstT; Provisional; Region: PRK13628 1155766000977 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1155766000978 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 1155766000979 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1155766000980 dimerization interface 3.5A [polypeptide binding]; other site 1155766000981 active site 1155766000982 6-pyruvoyl-tetrahydropterin synthase related domain; membrane protein; Region: PTPS_related; pfam10131 1155766000983 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1155766000984 MULE transposase domain; Region: MULE; pfam10551 1155766000985 6-pyruvoyl-tetrahydropterin synthase related domain; membrane protein; Region: PTPS_related; pfam10131 1155766000986 Enterocin A Immunity; Region: EntA_Immun; pfam08951 1155766000987 methionine sulfoxide reductase A; Provisional; Region: PRK14054 1155766000988 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1155766000989 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1155766000990 active site 1155766000991 catalytic tetrad [active] 1155766000992 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1155766000993 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1155766000994 DNA-binding site [nucleotide binding]; DNA binding site 1155766000995 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1155766000996 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 1155766000997 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1155766000998 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 1155766000999 beta-galactosidase; Region: BGL; TIGR03356 1155766001000 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 1155766001001 active site 1155766001002 P-loop; other site 1155766001003 phosphorylation site [posttranslational modification] 1155766001004 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 1155766001005 active site 1155766001006 methionine cluster; other site 1155766001007 phosphorylation site [posttranslational modification] 1155766001008 metal binding site [ion binding]; metal-binding site 1155766001009 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 1155766001010 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1155766001011 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1155766001012 Coenzyme A binding pocket [chemical binding]; other site 1155766001013 YrhK-like protein; Region: YrhK; pfam14145 1155766001014 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 1155766001015 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1155766001016 NAD binding site [chemical binding]; other site 1155766001017 catalytic Zn binding site [ion binding]; other site 1155766001018 structural Zn binding site [ion binding]; other site 1155766001019 Streptococcal 67 kDa myosin-cross-reactive antigen like family; Region: Strep_67kDa_ant; cl17487 1155766001020 Protein of unknown function (DUF1622); Region: DUF1622; pfam07784 1155766001021 Protein of unknown function (DUF1622); Region: DUF1622; pfam07784 1155766001022 M protein trans-acting positive regulator (MGA) HTH domain; Region: HTH_Mga; pfam08280 1155766001023 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1155766001024 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1155766001025 catalytic residue [active] 1155766001026 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 1155766001027 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1155766001028 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1155766001029 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 1155766001030 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1155766001031 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1155766001032 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 1155766001033 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1155766001034 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1155766001035 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 1155766001036 Mga helix-turn-helix domain; Region: Mga; pfam05043 1155766001037 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1155766001038 Protein of unknown function (DUF419); Region: DUF419; cl15265 1155766001039 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1155766001040 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1155766001041 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1155766001042 dimerization interface [polypeptide binding]; other site 1155766001043 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1155766001044 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1155766001045 malonate decarboxylase, alpha subunit; Region: mdcA; TIGR01110 1155766001046 Coenzyme A transferase; Region: CoA_trans; cl17247 1155766001047 malonate decarboxylase acyl carrier protein; Region: malonate_delta; TIGR03130 1155766001048 malonate decarboxylase, beta subunit; Region: malonate_beta; TIGR03133 1155766001049 malonate decarboxylase, gamma subunit; Region: malonate_gamma; TIGR03134 1155766001050 malonate decarboxylase holo-[acyl-carrier-protein] synthase; Region: malonate_mdcG; TIGR03135 1155766001051 Phosphoribosyl-dephospho-CoA transferase MdcG; Region: MdcG; pfam10620 1155766001052 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1155766001053 triphosphoribosyl-dephospho-CoA synthase MdcB; Region: malonate_mdcB; TIGR03132 1155766001054 Tim44-like domain; Region: Tim44; cl09208 1155766001055 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1155766001056 PRD domain; Region: PRD; pfam00874 1155766001057 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1155766001058 active site 1155766001059 P-loop; other site 1155766001060 phosphorylation site [posttranslational modification] 1155766001061 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1155766001062 active site 1155766001063 phosphorylation site [posttranslational modification] 1155766001064 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 1155766001065 active site 1155766001066 P-loop; other site 1155766001067 phosphorylation site [posttranslational modification] 1155766001068 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: PRK12997 1155766001069 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1155766001070 intersubunit interface [polypeptide binding]; other site 1155766001071 active site 1155766001072 zinc binding site [ion binding]; other site 1155766001073 Na+ binding site [ion binding]; other site 1155766001074 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1155766001075 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 1155766001076 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 1155766001077 nudix motif; other site 1155766001078 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1155766001079 MarR family; Region: MarR; pfam01047 1155766001080 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1155766001081 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1155766001082 Coenzyme A binding pocket [chemical binding]; other site 1155766001083 Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382 1155766001084 B3/4 domain; Region: B3_4; pfam03483 1155766001085 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1155766001086 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1155766001087 active site 1155766001088 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1155766001089 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1155766001090 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1155766001091 Ca binding site [ion binding]; other site 1155766001092 active site 1155766001093 catalytic site [active] 1155766001094 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 1155766001095 beta-galactosidase; Region: BGL; TIGR03356 1155766001096 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1155766001097 HTH domain; Region: HTH_11; pfam08279 1155766001098 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 1155766001099 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1155766001100 active site turn [active] 1155766001101 phosphorylation site [posttranslational modification] 1155766001102 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1155766001103 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 1155766001104 HPr interaction site; other site 1155766001105 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1155766001106 active site 1155766001107 phosphorylation site [posttranslational modification] 1155766001108 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 1155766001109 beta-galactosidase; Region: BGL; TIGR03356 1155766001110 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1155766001111 MarR family; Region: MarR; pfam01047 1155766001112 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 1155766001113 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1155766001114 putative active site [active] 1155766001115 putative FMN binding site [chemical binding]; other site 1155766001116 putative substrate binding site [chemical binding]; other site 1155766001117 putative catalytic residue [active] 1155766001118 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 1155766001119 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 1155766001120 potential catalytic triad [active] 1155766001121 conserved cys residue [active] 1155766001122 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 1155766001123 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1155766001124 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1155766001125 Mga helix-turn-helix domain; Region: Mga; pfam05043 1155766001126 glycerol kinase; Provisional; Region: glpK; PRK00047 1155766001127 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 1155766001128 N- and C-terminal domain interface [polypeptide binding]; other site 1155766001129 active site 1155766001130 MgATP binding site [chemical binding]; other site 1155766001131 catalytic site [active] 1155766001132 metal binding site [ion binding]; metal-binding site 1155766001133 glycerol binding site [chemical binding]; other site 1155766001134 homotetramer interface [polypeptide binding]; other site 1155766001135 homodimer interface [polypeptide binding]; other site 1155766001136 FBP binding site [chemical binding]; other site 1155766001137 protein IIAGlc interface [polypeptide binding]; other site 1155766001138 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 1155766001139 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 1155766001140 amphipathic channel; other site 1155766001141 Asn-Pro-Ala signature motifs; other site 1155766001142 potential frameshift: common BLAST hit: gi|29377437|ref|NP_816591.1| MutS2 family protein 1155766001143 MutS domain III; Region: MutS_III; pfam05192 1155766001144 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1155766001145 Walker A/P-loop; other site 1155766001146 ATP binding site [chemical binding]; other site 1155766001147 Q-loop/lid; other site 1155766001148 ABC transporter signature motif; other site 1155766001149 Walker B; other site 1155766001150 D-loop; other site 1155766001151 H-loop/switch region; other site 1155766001152 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 1155766001153 DsrE/DsrF-like family; Region: DrsE; cl00672 1155766001154 Uncharacterized protein YrkD from Bacillus subtilis and related domains; this domain superfamily was previously known as part of DUF156; Region: BsYrkD-like_DUF156; cd10155 1155766001155 putative homodimer interface [polypeptide binding]; other site 1155766001156 putative homotetramer interface [polypeptide binding]; other site 1155766001157 putative metal binding site [ion binding]; other site 1155766001158 putative homodimer-homodimer interface [polypeptide binding]; other site 1155766001159 putative allosteric switch controlling residues; other site 1155766001160 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1155766001161 active site residue [active] 1155766001162 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1155766001163 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 1155766001164 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1155766001165 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1155766001166 Member of the Rhodanese Homology Domain superfamily. Included in this CD are the Lactococcus lactis NADH oxidase, Bacillus cereus NADH dehydrogenase, and Bacteroides thetaiotaomicron pyridine nucleotide-disulphide oxidoreductase, and similar...; Region: RHOD_Pyr_redox; cd01524 1155766001167 active site residue [active] 1155766001168 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 1155766001169 Part of AAA domain; Region: AAA_19; pfam13245 1155766001170 Family description; Region: UvrD_C_2; pfam13538 1155766001171 N-glycosyltransferase; Provisional; Region: PRK11204 1155766001172 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 1155766001173 DXD motif; other site 1155766001174 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 1155766001175 dihydroxyacetone kinase, phosphotransfer subunit; Region: dha_pts; TIGR02364 1155766001176 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 1155766001177 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 1155766001178 dihydroxyacetone kinase, phosphoprotein-dependent, L subunit; Region: dha_L_ycgS; TIGR02365 1155766001179 Glucose-6-phosphate 1-dehydrogenase (EC 1.1.1.49); Region: G6PD_bact; pfam10786 1155766001180 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1155766001181 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1155766001182 ligand binding site [chemical binding]; other site 1155766001183 flexible hinge region; other site 1155766001184 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1155766001185 putative switch regulator; other site 1155766001186 non-specific DNA interactions [nucleotide binding]; other site 1155766001187 DNA binding site [nucleotide binding] 1155766001188 sequence specific DNA binding site [nucleotide binding]; other site 1155766001189 putative cAMP binding site [chemical binding]; other site 1155766001190 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 1155766001191 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1155766001192 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1155766001193 Walker A/P-loop; other site 1155766001194 ATP binding site [chemical binding]; other site 1155766001195 Q-loop/lid; other site 1155766001196 ABC transporter signature motif; other site 1155766001197 Walker B; other site 1155766001198 D-loop; other site 1155766001199 H-loop/switch region; other site 1155766001200 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 1155766001201 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1155766001202 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1155766001203 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 1155766001204 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 1155766001205 putative active site [active] 1155766001206 tyrosyl-tRNA synthetase; Provisional; Region: PRK13354 1155766001207 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 1155766001208 active site 1155766001209 HIGH motif; other site 1155766001210 dimer interface [polypeptide binding]; other site 1155766001211 KMSKS motif; other site 1155766001212 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1155766001213 RNA binding surface [nucleotide binding]; other site 1155766001214 tyrosine decarboxylase, Enterococcus type; Region: tyr_de_CO2_Ent; TIGR03811 1155766001215 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1155766001216 catalytic residue [active] 1155766001217 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 1155766001218 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 1155766001219 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1155766001220 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1155766001221 DNA binding site [nucleotide binding] 1155766001222 domain linker motif; other site 1155766001223 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 1155766001224 putative dimerization interface [polypeptide binding]; other site 1155766001225 putative ligand binding site [chemical binding]; other site 1155766001226 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 1155766001227 active site 1155766001228 catalytic residues [active] 1155766001229 beta-phosphoglucomutase; Region: bPGM; TIGR01990 1155766001230 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1155766001231 motif II; other site 1155766001232 maltose phosphorylase; Provisional; Region: PRK13807 1155766001233 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 1155766001234 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 1155766001235 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 1155766001236 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1155766001237 PTS system, IIBC component; Region: PTS-II-BC-unk1; TIGR02003 1155766001238 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1155766001239 active site turn [active] 1155766001240 phosphorylation site [posttranslational modification] 1155766001241 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 1155766001242 HPr interaction site; other site 1155766001243 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1155766001244 active site 1155766001245 phosphorylation site [posttranslational modification] 1155766001246 Streptococcus agalactiae RgfB, part of a putative two component signal transduction system, and related proteins; Region: RgfB-like; cd09079 1155766001247 putative catalytic site [active] 1155766001248 putative metal binding site [ion binding]; other site 1155766001249 putative phosphate binding site [ion binding]; other site 1155766001250 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 1155766001251 active site 1155766001252 catalytic site [active] 1155766001253 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1155766001254 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1155766001255 Coenzyme A binding pocket [chemical binding]; other site 1155766001256 Phenolic acid decarboxylase (PAD); Region: PA_decarbox; cl01382 1155766001257 Predicted transcriptional regulators [Transcription]; Region: COG1695 1155766001258 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1155766001259 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 1155766001260 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 1155766001261 DNA binding residues [nucleotide binding] 1155766001262 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1155766001263 putative dimer interface [polypeptide binding]; other site 1155766001264 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1155766001265 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1155766001266 putative substrate translocation pore; other site 1155766001267 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1155766001268 Urea transporter; Region: UT; cl01829 1155766001269 Domain of unknown function (DUF1905); Region: DUF1905; pfam08922 1155766001270 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 1155766001271 Flavoprotein; Region: Flavoprotein; pfam02441 1155766001272 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; pfam01977 1155766001273 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1155766001274 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1155766001275 Walker A/P-loop; other site 1155766001276 ATP binding site [chemical binding]; other site 1155766001277 Q-loop/lid; other site 1155766001278 ABC transporter signature motif; other site 1155766001279 Walker B; other site 1155766001280 D-loop; other site 1155766001281 H-loop/switch region; other site 1155766001282 FtsX-like permease family; Region: FtsX; pfam02687 1155766001283 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1155766001284 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1155766001285 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1155766001286 active site 1155766001287 phosphorylation site [posttranslational modification] 1155766001288 intermolecular recognition site; other site 1155766001289 dimerization interface [polypeptide binding]; other site 1155766001290 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1155766001291 DNA binding site [nucleotide binding] 1155766001292 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1155766001293 HAMP domain; Region: HAMP; pfam00672 1155766001294 dimerization interface [polypeptide binding]; other site 1155766001295 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1155766001296 dimer interface [polypeptide binding]; other site 1155766001297 phosphorylation site [posttranslational modification] 1155766001298 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1155766001299 ATP binding site [chemical binding]; other site 1155766001300 Mg2+ binding site [ion binding]; other site 1155766001301 G-X-G motif; other site 1155766001302 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1155766001303 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1155766001304 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1155766001305 dimerization interface [polypeptide binding]; other site 1155766001306 Protein of unknown function (DUF554); Region: DUF554; pfam04474 1155766001307 Predicted transcriptional regulators [Transcription]; Region: COG1695 1155766001308 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1155766001309 dimerization interface [polypeptide binding]; other site 1155766001310 putative Zn2+ binding site [ion binding]; other site 1155766001311 putative DNA binding site [nucleotide binding]; other site 1155766001312 Predicted membrane protein [Function unknown]; Region: COG4709 1155766001313 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 1155766001314 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_2; cd03402 1155766001315 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1155766001316 Protein of unknown function (DUF1093); Region: DUF1093; cl02185 1155766001317 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1155766001318 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1155766001319 Walker A/P-loop; other site 1155766001320 ATP binding site [chemical binding]; other site 1155766001321 Q-loop/lid; other site 1155766001322 ABC transporter signature motif; other site 1155766001323 Walker B; other site 1155766001324 D-loop; other site 1155766001325 H-loop/switch region; other site 1155766001326 FtsX-like permease family; Region: FtsX; pfam02687 1155766001327 potential frameshift: common BLAST hit: gi|67078215|ref|YP_245835.1| aldose 1-epimerase 1155766001328 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 1155766001329 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 1155766001330 active site 1155766001331 catalytic residues [active] 1155766001332 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1155766001333 NlpC/P60 family; Region: NLPC_P60; pfam00877 1155766001334 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 1155766001335 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cl00164 1155766001336 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 1155766001337 active site turn [active] 1155766001338 phosphorylation site [posttranslational modification] 1155766001339 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1155766001340 D-ribose pyranase; Provisional; Region: PRK11797 1155766001341 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1155766001342 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1155766001343 substrate binding site [chemical binding]; other site 1155766001344 dimer interface [polypeptide binding]; other site 1155766001345 ATP binding site [chemical binding]; other site 1155766001346 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1155766001347 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1155766001348 DNA binding site [nucleotide binding] 1155766001349 domain linker motif; other site 1155766001350 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1155766001351 dimerization interface [polypeptide binding]; other site 1155766001352 ligand binding site [chemical binding]; other site 1155766001353 Isochorismatase family; Region: Isochorismatase; pfam00857 1155766001354 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1155766001355 catalytic triad [active] 1155766001356 conserved cis-peptide bond; other site 1155766001357 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1155766001358 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1155766001359 Walker A/P-loop; other site 1155766001360 ATP binding site [chemical binding]; other site 1155766001361 Q-loop/lid; other site 1155766001362 ABC transporter signature motif; other site 1155766001363 Walker B; other site 1155766001364 D-loop; other site 1155766001365 H-loop/switch region; other site 1155766001366 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1155766001367 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1155766001368 FtsX-like permease family; Region: FtsX; pfam02687 1155766001369 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1155766001370 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1155766001371 Ca binding site [ion binding]; other site 1155766001372 active site 1155766001373 catalytic site [active] 1155766001374 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1155766001375 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1155766001376 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 1155766001377 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 1155766001378 metal binding site [ion binding]; metal-binding site 1155766001379 YodA lipocalin-like domain; Region: YodA; pfam09223 1155766001380 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 1155766001381 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1155766001382 active site 1155766001383 phosphorylation site [posttranslational modification] 1155766001384 intermolecular recognition site; other site 1155766001385 LytTr DNA-binding domain; Region: LytTR; pfam04397 1155766001386 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 1155766001387 Accessory gene regulator B; Region: AgrB; pfam04647 1155766001388 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 1155766001389 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 1155766001390 Substrate-binding site [chemical binding]; other site 1155766001391 Substrate specificity [chemical binding]; other site 1155766001392 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 1155766001393 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1155766001394 Part of AAA domain; Region: AAA_19; pfam13245 1155766001395 Family description; Region: UvrD_C_2; pfam13538 1155766001396 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 1155766001397 ArsC family; Region: ArsC; pfam03960 1155766001398 putative catalytic residues [active] 1155766001399 thiol/disulfide switch; other site 1155766001400 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 1155766001401 ArsC family; Region: ArsC; pfam03960 1155766001402 putative catalytic residues [active] 1155766001403 thiol/disulfide switch; other site 1155766001404 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 1155766001405 catalytic residues [active] 1155766001406 dimer interface [polypeptide binding]; other site 1155766001407 S-ribosylhomocysteinase; Provisional; Region: PRK02260 1155766001408 cystathionine gamma-synthase/cystathionine beta-lyase; Validated; Region: PRK06176 1155766001409 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1155766001410 homodimer interface [polypeptide binding]; other site 1155766001411 substrate-cofactor binding pocket; other site 1155766001412 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1155766001413 catalytic residue [active] 1155766001414 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1155766001415 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1155766001416 dimer interface [polypeptide binding]; other site 1155766001417 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1155766001418 catalytic residue [active] 1155766001419 elongation factor P; Validated; Region: PRK00529 1155766001420 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1155766001421 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1155766001422 RNA binding site [nucleotide binding]; other site 1155766001423 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1155766001424 RNA binding site [nucleotide binding]; other site 1155766001425 diaminopimelate decarboxylase; Region: lysA; TIGR01048 1155766001426 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1155766001427 active site 1155766001428 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1155766001429 substrate binding site [chemical binding]; other site 1155766001430 catalytic residues [active] 1155766001431 dimer interface [polypeptide binding]; other site 1155766001432 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 1155766001433 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1155766001434 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1155766001435 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1155766001436 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1155766001437 dimer interface [polypeptide binding]; other site 1155766001438 active site 1155766001439 catalytic residue [active] 1155766001440 dihydrodipicolinate reductase; Provisional; Region: PRK00048 1155766001441 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1155766001442 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 1155766001443 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 1155766001444 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 1155766001445 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 1155766001446 active site 1155766001447 trimer interface [polypeptide binding]; other site 1155766001448 substrate binding site [chemical binding]; other site 1155766001449 CoA binding site [chemical binding]; other site 1155766001450 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 1155766001451 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1155766001452 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 1155766001453 aspartate kinase; Reviewed; Region: PRK09034 1155766001454 putative catalytic residues [active] 1155766001455 putative nucleotide binding site [chemical binding]; other site 1155766001456 putative aspartate binding site [chemical binding]; other site 1155766001457 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 1155766001458 allosteric regulatory residue; other site 1155766001459 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 1155766001460 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 1155766001461 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1155766001462 metal binding site [ion binding]; metal-binding site 1155766001463 dimer interface [polypeptide binding]; other site 1155766001464 aromatic amino acid aminotransferase; Validated; Region: PRK07309 1155766001465 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1155766001466 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1155766001467 homodimer interface [polypeptide binding]; other site 1155766001468 catalytic residue [active] 1155766001469 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 1155766001470 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1155766001471 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1155766001472 Integrase core domain; Region: rve; pfam00665 1155766001473 Integrase core domain; Region: rve_2; pfam13333 1155766001474 Predicted membrane protein [Function unknown]; Region: COG2323 1155766001475 DNA polymerase IV; Reviewed; Region: PRK03103 1155766001476 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 1155766001477 active site 1155766001478 DNA binding site [nucleotide binding] 1155766001479 galactokinase; Provisional; Region: PRK05322 1155766001480 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 1155766001481 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1155766001482 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 1155766001483 active site 1155766001484 catalytic residues [active] 1155766001485 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 1155766001486 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 1155766001487 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1155766001488 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1155766001489 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1155766001490 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1155766001491 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 1155766001492 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1155766001493 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1155766001494 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1155766001495 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1155766001496 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1155766001497 ABC-ATPase subunit interface; other site 1155766001498 dimer interface [polypeptide binding]; other site 1155766001499 putative PBP binding regions; other site 1155766001500 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 1155766001501 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 1155766001502 metal binding site [ion binding]; metal-binding site 1155766001503 epoxyqueuosine reductase; Region: TIGR00276 1155766001504 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 1155766001505 4Fe-4S binding domain; Region: Fer4_6; pfam12837 1155766001506 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1155766001507 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270 1155766001508 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1155766001509 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1155766001510 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1155766001511 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1155766001512 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 1155766001513 Arginine repressor [Transcription]; Region: ArgR; COG1438 1155766001514 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1155766001515 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1155766001516 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 1155766001517 active site 1155766001518 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 1155766001519 substrate binding site [chemical binding]; other site 1155766001520 metal binding site [ion binding]; metal-binding site 1155766001521 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 1155766001522 pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK07251 1155766001523 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1155766001524 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1155766001525 Isochorismatase family; Region: Isochorismatase; pfam00857 1155766001526 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1155766001527 catalytic triad [active] 1155766001528 conserved cis-peptide bond; other site 1155766001529 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1155766001530 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1155766001531 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 1155766001532 Uncharacterized ACR, COG2135; Region: DUF159; cl03646 1155766001533 Flavin Reductases; Region: FlaRed; cl00801 1155766001534 PemK-like protein; Region: PemK; pfam02452 1155766001535 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 1155766001536 dimanganese center [ion binding]; other site 1155766001537 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1155766001538 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1155766001539 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1155766001540 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1155766001541 dimer interface [polypeptide binding]; other site 1155766001542 conserved gate region; other site 1155766001543 putative PBP binding loops; other site 1155766001544 ABC-ATPase subunit interface; other site 1155766001545 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1155766001546 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1155766001547 dimer interface [polypeptide binding]; other site 1155766001548 conserved gate region; other site 1155766001549 putative PBP binding loops; other site 1155766001550 ABC-ATPase subunit interface; other site 1155766001551 Protein of unknown function, DUF624; Region: DUF624; pfam04854 1155766001552 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 1155766001553 active site 1155766001554 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1155766001555 Selenocysteine-specific translation elongation factor [Translation, ribosomal structure and biogenesis]; Region: SelB; COG3276 1155766001556 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1155766001557 metal ion-dependent adhesion site (MIDAS); other site 1155766001558 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 1155766001559 Cna protein B-type domain; Region: Cna_B; pfam05738 1155766001560 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 1155766001561 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 1155766001562 active site 1155766001563 catalytic site [active] 1155766001564 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1155766001565 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1155766001566 active site 1155766001567 phosphorylation site [posttranslational modification] 1155766001568 intermolecular recognition site; other site 1155766001569 dimerization interface [polypeptide binding]; other site 1155766001570 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1155766001571 DNA binding site [nucleotide binding] 1155766001572 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1155766001573 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 1155766001574 dimer interface [polypeptide binding]; other site 1155766001575 phosphorylation site [posttranslational modification] 1155766001576 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1155766001577 ATP binding site [chemical binding]; other site 1155766001578 Mg2+ binding site [ion binding]; other site 1155766001579 G-X-G motif; other site 1155766001580 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 1155766001581 amino acid transporter; Region: 2A0306; TIGR00909 1155766001582 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 1155766001583 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 1155766001584 5-bromo-4-chloroindolyl phosphate hydrolysis protein; Region: Halogen_Hydrol; pfam10112 1155766001585 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1155766001586 dimer interface [polypeptide binding]; other site 1155766001587 ADP-ribose binding site [chemical binding]; other site 1155766001588 active site 1155766001589 nudix motif; other site 1155766001590 metal binding site [ion binding]; metal-binding site 1155766001591 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 1155766001592 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 1155766001593 Isochorismatase family; Region: Isochorismatase; pfam00857 1155766001594 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1155766001595 catalytic triad [active] 1155766001596 conserved cis-peptide bond; other site 1155766001597 Right handed beta helix region; Region: Beta_helix; pfam13229 1155766001598 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 1155766001599 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 1155766001600 active site 1155766001601 Zn binding site [ion binding]; other site 1155766001602 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02458 1155766001603 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1155766001604 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1155766001605 active site 1155766001606 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1155766001607 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1155766001608 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1155766001609 catalytic residue [active] 1155766001610 Putative amino acid metabolism; Region: DUF1831; pfam08866 1155766001611 H+ Antiporter protein; Region: 2A0121; TIGR00900 1155766001612 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1155766001613 putative substrate translocation pore; other site 1155766001614 Aquifex aeolicus AQ1575 and related proteins, metallophosphatase domain; Region: MPP_AQ1575; cd07390 1155766001615 putative active site [active] 1155766001616 putative metal binding site [ion binding]; other site 1155766001617 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 1155766001618 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 1155766001619 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 1155766001620 transaminase; Validated; Region: PRK07324 1155766001621 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1155766001622 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1155766001623 homodimer interface [polypeptide binding]; other site 1155766001624 catalytic residue [active] 1155766001625 drug efflux system protein MdtG; Provisional; Region: PRK09874 1155766001626 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1155766001627 putative substrate translocation pore; other site 1155766001628 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1155766001629 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1155766001630 Uncharacterized conserved protein (DUF2183); Region: DUF2183; pfam09949 1155766001631 WHG domain; Region: WHG; pfam13305 1155766001632 Protein of unknown function (DUF1033); Region: DUF1033; pfam06279 1155766001633 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 1155766001634 DNA topoisomerase III; Provisional; Region: PRK07726 1155766001635 active site 1155766001636 putative metal-binding site [ion binding]; other site 1155766001637 putative interdomain interaction site [polypeptide binding]; other site 1155766001638 putative nucleotide binding site [chemical binding]; other site 1155766001639 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1155766001640 domain I; other site 1155766001641 DNA binding groove [nucleotide binding] 1155766001642 phosphate binding site [ion binding]; other site 1155766001643 domain II; other site 1155766001644 domain III; other site 1155766001645 nucleotide binding site [chemical binding]; other site 1155766001646 catalytic site [active] 1155766001647 domain IV; other site 1155766001648 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1155766001649 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 1155766001650 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1155766001651 Ligand binding site; other site 1155766001652 Putative Catalytic site; other site 1155766001653 DXD motif; other site 1155766001654 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 1155766001655 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 1155766001656 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1155766001657 DNA binding site [nucleotide binding] 1155766001658 active site 1155766001659 Predicted membrane protein [Function unknown]; Region: COG2855 1155766001660 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 1155766001661 C4-dicarboxylate transporters of the Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_C4-dicarb_trans; cd09325 1155766001662 gating phenylalanine in ion channel; other site 1155766001663 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1155766001664 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1155766001665 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1155766001666 dimerization interface [polypeptide binding]; other site 1155766001667 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 1155766001668 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 1155766001669 ArsC family; Region: ArsC; pfam03960 1155766001670 putative ArsC-like catalytic residues; other site 1155766001671 putative TRX-like catalytic residues [active] 1155766001672 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1155766001673 lipoyl attachment site [posttranslational modification]; other site 1155766001674 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1155766001675 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 1155766001676 Walker A/P-loop; other site 1155766001677 ATP binding site [chemical binding]; other site 1155766001678 Q-loop/lid; other site 1155766001679 ABC transporter signature motif; other site 1155766001680 Walker B; other site 1155766001681 D-loop; other site 1155766001682 H-loop/switch region; other site 1155766001683 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 1155766001684 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1155766001685 conserved gate region; other site 1155766001686 ABC-ATPase subunit interface; other site 1155766001687 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1155766001688 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1155766001689 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 1155766001690 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 1155766001691 Walker A/P-loop; other site 1155766001692 ATP binding site [chemical binding]; other site 1155766001693 Q-loop/lid; other site 1155766001694 ABC transporter signature motif; other site 1155766001695 Walker B; other site 1155766001696 D-loop; other site 1155766001697 H-loop/switch region; other site 1155766001698 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 1155766001699 FeS assembly protein SufD; Region: sufD; TIGR01981 1155766001700 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1155766001701 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1155766001702 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1155766001703 catalytic residue [active] 1155766001704 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 1155766001705 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1155766001706 trimerization site [polypeptide binding]; other site 1155766001707 active site 1155766001708 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 1155766001709 FeS assembly protein SufB; Region: sufB; TIGR01980 1155766001710 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 1155766001711 Int/Topo IB signature motif; other site 1155766001712 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1155766001713 non-specific DNA binding site [nucleotide binding]; other site 1155766001714 salt bridge; other site 1155766001715 sequence-specific DNA binding site [nucleotide binding]; other site 1155766001716 Helix-turn-helix domain; Region: HTH_17; pfam12728 1155766001717 CHC2 zinc finger; Region: zf-CHC2; cl17510 1155766001718 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1155766001719 non-specific DNA binding site [nucleotide binding]; other site 1155766001720 salt bridge; other site 1155766001721 sequence-specific DNA binding site [nucleotide binding]; other site 1155766001722 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1155766001723 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1155766001724 non-specific DNA binding site [nucleotide binding]; other site 1155766001725 salt bridge; other site 1155766001726 sequence-specific DNA binding site [nucleotide binding]; other site 1155766001727 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 1155766001728 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 1155766001729 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1155766001730 active site turn [active] 1155766001731 phosphorylation site [posttranslational modification] 1155766001732 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1155766001733 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 1155766001734 HPr interaction site; other site 1155766001735 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1155766001736 active site 1155766001737 phosphorylation site [posttranslational modification] 1155766001738 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 1155766001739 beta-galactosidase; Region: BGL; TIGR03356 1155766001740 transcriptional antiterminator BglG; Provisional; Region: PRK09772 1155766001741 CAT RNA binding domain; Region: CAT_RBD; smart01061 1155766001742 PRD domain; Region: PRD; pfam00874 1155766001743 PRD domain; Region: PRD; pfam00874 1155766001744 HsdM N-terminal domain; Region: HsdM_N; pfam12161 1155766001745 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 1155766001746 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1155766001747 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1155766001748 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 1155766001749 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1155766001750 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 1155766001751 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 1155766001752 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1155766001753 ATP binding site [chemical binding]; other site 1155766001754 putative Mg++ binding site [ion binding]; other site 1155766001755 Transposase domain (DUF772); Region: DUF772; pfam05598 1155766001756 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1155766001757 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1155766001758 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1155766001759 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1155766001760 non-specific DNA binding site [nucleotide binding]; other site 1155766001761 salt bridge; other site 1155766001762 sequence-specific DNA binding site [nucleotide binding]; other site 1155766001763 Protein of unknown function (DUF1093); Region: DUF1093; cl02185 1155766001764 Protein of unknown function (DUF1430); Region: DUF1430; pfam07242 1155766001765 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1155766001766 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 1155766001767 Walker A/P-loop; other site 1155766001768 ATP binding site [chemical binding]; other site 1155766001769 Q-loop/lid; other site 1155766001770 ABC transporter signature motif; other site 1155766001771 Walker B; other site 1155766001772 D-loop; other site 1155766001773 H-loop/switch region; other site 1155766001774 foldase protein PrsA; Reviewed; Region: prsA; PRK01326 1155766001775 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 1155766001776 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1155766001777 WxL domain surface cell wall-binding; Region: WxL; pfam13731 1155766001778 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 1155766001779 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 1155766001780 WxL domain surface cell wall-binding; Region: WxL; pfam13731 1155766001781 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 1155766001782 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1155766001783 active site 1155766001784 phosphorylation site [posttranslational modification] 1155766001785 intermolecular recognition site; other site 1155766001786 dimerization interface [polypeptide binding]; other site 1155766001787 LytTr DNA-binding domain; Region: LytTR; smart00850 1155766001788 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1155766001789 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1155766001790 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1155766001791 Predicted transcriptional regulators [Transcription]; Region: COG1733 1155766001792 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1155766001793 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537 1155766001794 homodimer interface [polypeptide binding]; other site 1155766001795 chemical substrate binding site [chemical binding]; other site 1155766001796 oligomer interface [polypeptide binding]; other site 1155766001797 metal binding site [ion binding]; metal-binding site 1155766001798 Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165 1155766001799 active site 1155766001800 catalytic site [active] 1155766001801 transcriptional antiterminator BglG; Provisional; Region: PRK09772 1155766001802 CAT RNA binding domain; Region: CAT_RBD; smart01061 1155766001803 PRD domain; Region: PRD; pfam00874 1155766001804 PRD domain; Region: PRD; pfam00874 1155766001805 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 1155766001806 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1155766001807 active site turn [active] 1155766001808 phosphorylation site [posttranslational modification] 1155766001809 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1155766001810 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 1155766001811 HPr interaction site; other site 1155766001812 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1155766001813 active site 1155766001814 phosphorylation site [posttranslational modification] 1155766001815 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 1155766001816 beta-galactosidase; Region: BGL; TIGR03356 1155766001817 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1155766001818 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1155766001819 DNA-binding site [nucleotide binding]; DNA binding site 1155766001820 UTRA domain; Region: UTRA; pfam07702 1155766001821 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425 1155766001822 Possible lysine decarboxylase; Region: Lysine_decarbox; pfam03641 1155766001823 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014 1155766001824 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 1155766001825 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 1155766001826 Substrate-binding site [chemical binding]; other site 1155766001827 Substrate specificity [chemical binding]; other site 1155766001828 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1155766001829 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1155766001830 DNA binding site [nucleotide binding] 1155766001831 domain linker motif; other site 1155766001832 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1155766001833 ligand binding site [chemical binding]; other site 1155766001834 dimerization interface [polypeptide binding]; other site 1155766001835 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 1155766001836 beta-galactosidase; Region: BGL; TIGR03356 1155766001837 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 1155766001838 Sulfatase; Region: Sulfatase; pfam00884 1155766001839 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1155766001840 non-specific DNA binding site [nucleotide binding]; other site 1155766001841 salt bridge; other site 1155766001842 sequence-specific DNA binding site [nucleotide binding]; other site 1155766001843 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 1155766001844 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 1155766001845 active site 1155766001846 multimer interface [polypeptide binding]; other site 1155766001847 magnesium-transporting ATPase; Provisional; Region: PRK15122 1155766001848 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 1155766001849 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1155766001850 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1155766001851 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 1155766001852 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1155766001853 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 1155766001854 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1155766001855 motif II; other site 1155766001856 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 1155766001857 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1155766001858 Walker A/P-loop; other site 1155766001859 ATP binding site [chemical binding]; other site 1155766001860 Q-loop/lid; other site 1155766001861 ABC transporter signature motif; other site 1155766001862 Walker B; other site 1155766001863 D-loop; other site 1155766001864 H-loop/switch region; other site 1155766001865 NIL domain; Region: NIL; pfam09383 1155766001866 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1155766001867 dimer interface [polypeptide binding]; other site 1155766001868 conserved gate region; other site 1155766001869 ABC-ATPase subunit interface; other site 1155766001870 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1155766001871 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1155766001872 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 1155766001873 amidohydrolase; Region: amidohydrolases; TIGR01891 1155766001874 metal binding site [ion binding]; metal-binding site 1155766001875 Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553 1155766001876 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1155766001877 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 1155766001878 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1155766001879 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1155766001880 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 1155766001881 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1155766001882 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1155766001883 ABC transporter; Region: ABC_tran_2; pfam12848 1155766001884 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1155766001885 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1155766001886 catalytic core [active] 1155766001887 Uncharacterized conserved protein [Function unknown]; Region: COG3589 1155766001888 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 1155766001889 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 1155766001890 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 1155766001891 putative active site [active] 1155766001892 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 1155766001893 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1155766001894 active site turn [active] 1155766001895 phosphorylation site [posttranslational modification] 1155766001896 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1155766001897 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 1155766001898 HPr interaction site; other site 1155766001899 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1155766001900 active site 1155766001901 phosphorylation site [posttranslational modification] 1155766001902 NrdI Flavodoxin like; Region: Flavodoxin_NdrI; cl17293 1155766001903 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 1155766001904 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 1155766001905 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1155766001906 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1155766001907 Walker A/P-loop; other site 1155766001908 ATP binding site [chemical binding]; other site 1155766001909 Q-loop/lid; other site 1155766001910 ABC transporter signature motif; other site 1155766001911 Walker B; other site 1155766001912 D-loop; other site 1155766001913 H-loop/switch region; other site 1155766001914 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1155766001915 Protein of unknown function (DUF969); Region: DUF969; pfam06149 1155766001916 Predicted membrane protein [Function unknown]; Region: COG3817 1155766001917 Protein of unknown function (DUF979); Region: DUF979; pfam06166 1155766001918 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 1155766001919 putative substrate binding pocket [chemical binding]; other site 1155766001920 AC domain interface; other site 1155766001921 catalytic triad [active] 1155766001922 AB domain interface; other site 1155766001923 interchain disulfide; other site 1155766001924 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 1155766001925 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 1155766001926 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1155766001927 putative metal binding site [ion binding]; other site 1155766001928 Protein of unknown function (DUF2874); Region: DUF2874; pfam11396 1155766001929 cxxc_20_cxxc protein; Region: cxxc_20_cxxc; TIGR04104 1155766001930 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1155766001931 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1155766001932 Coenzyme A binding pocket [chemical binding]; other site 1155766001933 Tubby C 2; Region: Tub_2; cl02043 1155766001934 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1155766001935 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1155766001936 active site 1155766001937 motif I; other site 1155766001938 motif II; other site 1155766001939 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1155766001940 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 1155766001941 ligand binding site [chemical binding]; other site 1155766001942 active site 1155766001943 UGI interface [polypeptide binding]; other site 1155766001944 catalytic site [active] 1155766001945 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 1155766001946 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 1155766001947 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1155766001948 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1155766001949 Coenzyme A binding pocket [chemical binding]; other site 1155766001950 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1155766001951 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 1155766001952 active site 1155766001953 catalytic site [active] 1155766001954 substrate binding site [chemical binding]; other site 1155766001955 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 1155766001956 active site 1155766001957 putative catalytic site [active] 1155766001958 DNA binding site [nucleotide binding] 1155766001959 putative phosphate binding site [ion binding]; other site 1155766001960 metal binding site A [ion binding]; metal-binding site 1155766001961 AP binding site [nucleotide binding]; other site 1155766001962 metal binding site B [ion binding]; metal-binding site 1155766001963 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1155766001964 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1155766001965 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1155766001966 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 1155766001967 FAD binding domain; Region: FAD_binding_4; pfam01565 1155766001968 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1155766001969 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 1155766001970 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1155766001971 Mga helix-turn-helix domain; Region: Mga; pfam05043 1155766001972 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 1155766001973 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 1155766001974 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 1155766001975 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1155766001976 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1155766001977 Coenzyme A binding pocket [chemical binding]; other site 1155766001978 fumarate reductase flavoprotein subunit; Validated; Region: PRK06481 1155766001979 L-aspartate oxidase; Provisional; Region: PRK06175 1155766001980 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 1155766001981 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 1155766001982 NAD(P) binding site [chemical binding]; other site 1155766001983 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 1155766001984 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1155766001985 NAD(P) binding site [chemical binding]; other site 1155766001986 putative active site [active] 1155766001987 Predicted membrane protein [Function unknown]; Region: COG4684 1155766001988 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 1155766001989 phosphopantothenoylcysteine decarboxylase; Validated; Region: PRK07313 1155766001990 Flavoprotein; Region: Flavoprotein; pfam02441 1155766001991 DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410 1155766001992 Yhdh and yhfp-like putative quinone oxidoreductases; Region: MDR_yhdh_yhfp; cd05280 1155766001993 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 1155766001994 NADP binding site [chemical binding]; other site 1155766001995 dimer interface [polypeptide binding]; other site 1155766001996 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1155766001997 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1155766001998 non-specific DNA binding site [nucleotide binding]; other site 1155766001999 salt bridge; other site 1155766002000 sequence-specific DNA binding site [nucleotide binding]; other site 1155766002001 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1155766002002 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 1155766002003 Walker A/P-loop; other site 1155766002004 ATP binding site [chemical binding]; other site 1155766002005 Q-loop/lid; other site 1155766002006 ABC transporter signature motif; other site 1155766002007 Walker B; other site 1155766002008 D-loop; other site 1155766002009 H-loop/switch region; other site 1155766002010 TOBE domain; Region: TOBE_2; pfam08402 1155766002011 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1155766002012 dimer interface [polypeptide binding]; other site 1155766002013 conserved gate region; other site 1155766002014 putative PBP binding loops; other site 1155766002015 ABC-ATPase subunit interface; other site 1155766002016 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1155766002017 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1155766002018 dimer interface [polypeptide binding]; other site 1155766002019 conserved gate region; other site 1155766002020 putative PBP binding loops; other site 1155766002021 ABC-ATPase subunit interface; other site 1155766002022 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 1155766002023 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1155766002024 Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775 1155766002025 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1155766002026 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1155766002027 Walker A motif; other site 1155766002028 ATP binding site [chemical binding]; other site 1155766002029 Walker B motif; other site 1155766002030 arginine finger; other site 1155766002031 Transcriptional antiterminator [Transcription]; Region: COG3933 1155766002032 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 1155766002033 active site 1155766002034 active pocket/dimerization site; other site 1155766002035 phosphorylation site [posttranslational modification] 1155766002036 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 1155766002037 active pocket/dimerization site; other site 1155766002038 active site 1155766002039 phosphorylation site [posttranslational modification] 1155766002040 PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830 1155766002041 active site 1155766002042 phosphorylation site [posttranslational modification] 1155766002043 PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609 1155766002044 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 1155766002045 Protein of unknown function (DUF2961); Region: DUF2961; pfam11175 1155766002046 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1155766002047 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1155766002048 nucleotide binding site [chemical binding]; other site 1155766002049 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1155766002050 transcriptional repressor DicA; Reviewed; Region: PRK09706 1155766002051 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1155766002052 non-specific DNA binding site [nucleotide binding]; other site 1155766002053 salt bridge; other site 1155766002054 sequence-specific DNA binding site [nucleotide binding]; other site 1155766002055 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1155766002056 non-specific DNA binding site [nucleotide binding]; other site 1155766002057 salt bridge; other site 1155766002058 Replication initiation factor; Region: Rep_trans; pfam02486 1155766002059 Domain of unknown function (DUF3173); Region: DUF3173; pfam11372 1155766002060 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1155766002061 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1155766002062 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 1155766002063 Int/Topo IB signature motif; other site 1155766002064 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1155766002065 substrate binding site [chemical binding]; other site 1155766002066 THF binding site; other site 1155766002067 zinc-binding site [ion binding]; other site 1155766002068 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1155766002069 Integrase core domain; Region: rve; pfam00665 1155766002070 Integrase core domain; Region: rve_3; cl15866 1155766002071 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 1155766002072 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1155766002073 DNA binding residues [nucleotide binding] 1155766002074 putative dimer interface [polypeptide binding]; other site 1155766002075 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1155766002076 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1155766002077 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1155766002078 CTP synthetase; Validated; Region: pyrG; PRK05380 1155766002079 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 1155766002080 Catalytic site [active] 1155766002081 active site 1155766002082 UTP binding site [chemical binding]; other site 1155766002083 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 1155766002084 active site 1155766002085 putative oxyanion hole; other site 1155766002086 catalytic triad [active] 1155766002087 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1155766002088 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1155766002089 intersubunit interface [polypeptide binding]; other site 1155766002090 active site 1155766002091 zinc binding site [ion binding]; other site 1155766002092 Na+ binding site [ion binding]; other site 1155766002093 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1155766002094 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1155766002095 hinge; other site 1155766002096 active site 1155766002097 transcription termination factor Rho; Provisional; Region: rho; PRK09376 1155766002098 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 1155766002099 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 1155766002100 RNA binding site [nucleotide binding]; other site 1155766002101 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1155766002102 Walker A motif; other site 1155766002103 ATP binding site [chemical binding]; other site 1155766002104 Walker B motif; other site 1155766002105 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 1155766002106 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1155766002107 active site 1155766002108 phosphorylation site [posttranslational modification] 1155766002109 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 1155766002110 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1155766002111 active site 1155766002112 P-loop; other site 1155766002113 phosphorylation site [posttranslational modification] 1155766002114 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 1155766002115 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1155766002116 intersubunit interface [polypeptide binding]; other site 1155766002117 active site 1155766002118 zinc binding site [ion binding]; other site 1155766002119 Na+ binding site [ion binding]; other site 1155766002120 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1155766002121 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1155766002122 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1155766002123 Protein of unknown function (DUF2512); Region: DUF2512; pfam10710 1155766002124 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1155766002125 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1155766002126 putative substrate translocation pore; other site 1155766002127 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1155766002128 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1155766002129 ligand binding site [chemical binding]; other site 1155766002130 flexible hinge region; other site 1155766002131 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1155766002132 non-specific DNA interactions [nucleotide binding]; other site 1155766002133 DNA binding site [nucleotide binding] 1155766002134 sequence specific DNA binding site [nucleotide binding]; other site 1155766002135 putative cAMP binding site [chemical binding]; other site 1155766002136 Repair protein; Region: Repair_PSII; pfam04536 1155766002137 YycH protein; Region: YycI; cl02015 1155766002138 Membrane protease subunit, stomatin/prohibitin family [Amino acid transport and metabolism]; Region: COG4260 1155766002139 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_5; cd03408 1155766002140 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 1155766002141 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 1155766002142 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1155766002143 Walker A motif; other site 1155766002144 ATP binding site [chemical binding]; other site 1155766002145 Walker B motif; other site 1155766002146 arginine finger; other site 1155766002147 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 1155766002148 hypothetical protein; Validated; Region: PRK00153 1155766002149 recombination protein RecR; Reviewed; Region: recR; PRK00076 1155766002150 RecR protein; Region: RecR; pfam02132 1155766002151 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1155766002152 putative active site [active] 1155766002153 putative metal-binding site [ion binding]; other site 1155766002154 tetramer interface [polypeptide binding]; other site 1155766002155 thymidylate kinase; Validated; Region: tmk; PRK00698 1155766002156 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1155766002157 TMP-binding site; other site 1155766002158 ATP-binding site [chemical binding]; other site 1155766002159 Protein of unknown function (DUF970); Region: DUF970; cl17525 1155766002160 DNA polymerase III subunit delta'; Validated; Region: PRK08058 1155766002161 DNA polymerase III subunit delta'; Validated; Region: PRK08485 1155766002162 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 1155766002163 Protein of unknown function (DUF972); Region: DUF972; pfam06156 1155766002164 Predicted methyltransferases [General function prediction only]; Region: COG0313 1155766002165 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 1155766002166 putative SAM binding site [chemical binding]; other site 1155766002167 putative homodimer interface [polypeptide binding]; other site 1155766002168 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1155766002169 active site 1155766002170 DNA polymerase IV; Validated; Region: PRK02406 1155766002171 DNA binding site [nucleotide binding] 1155766002172 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 1155766002173 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1155766002174 FeS/SAM binding site; other site 1155766002175 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 1155766002176 ATP cone domain; Region: ATP-cone; pfam03477 1155766002177 Class III ribonucleotide reductase; Region: RNR_III; cd01675 1155766002178 effector binding site; other site 1155766002179 active site 1155766002180 Zn binding site [ion binding]; other site 1155766002181 glycine loop; other site 1155766002182 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1155766002183 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1155766002184 Walker A/P-loop; other site 1155766002185 ATP binding site [chemical binding]; other site 1155766002186 Q-loop/lid; other site 1155766002187 ABC transporter signature motif; other site 1155766002188 Walker B; other site 1155766002189 D-loop; other site 1155766002190 H-loop/switch region; other site 1155766002191 FtsX-like permease family; Region: FtsX; pfam02687 1155766002192 D-Ala-teichoic acid biosynthesis protein; Region: DUF3687; pfam12459 1155766002193 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 1155766002194 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 1155766002195 acyl-activating enzyme (AAE) consensus motif; other site 1155766002196 AMP binding site [chemical binding]; other site 1155766002197 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091 1155766002198 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087 1155766002199 D-alanyl-lipoteichoic acid biosynthesis protein DltD; Region: LTA_DltD; TIGR04092 1155766002200 DltD N-terminal region; Region: DltD_N; pfam04915 1155766002201 DltD central region; Region: DltD_M; pfam04918 1155766002202 DltD C-terminal region; Region: DltD_C; pfam04914 1155766002203 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 1155766002204 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 1155766002205 oligomer interface [polypeptide binding]; other site 1155766002206 active site 1155766002207 metal binding site [ion binding]; metal-binding site 1155766002208 Protein of unknown function (DUF975); Region: DUF975; cl10504 1155766002209 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 1155766002210 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1155766002211 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 1155766002212 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 1155766002213 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 1155766002214 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465 1155766002215 Catalytic site [active] 1155766002216 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1155766002217 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1155766002218 S-adenosylmethionine binding site [chemical binding]; other site 1155766002219 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 1155766002220 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1155766002221 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1155766002222 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1155766002223 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 1155766002224 Fe-S cluster binding site [ion binding]; other site 1155766002225 active site 1155766002226 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 1155766002227 Protein of unknown function (DUF464); Region: DUF464; pfam04327 1155766002228 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 1155766002229 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 1155766002230 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1155766002231 Walker A motif; other site 1155766002232 ATP binding site [chemical binding]; other site 1155766002233 Walker B motif; other site 1155766002234 arginine finger; other site 1155766002235 Transcriptional antiterminator [Transcription]; Region: COG3933 1155766002236 PRD domain; Region: PRD; pfam00874 1155766002237 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 1155766002238 active pocket/dimerization site; other site 1155766002239 active site 1155766002240 phosphorylation site [posttranslational modification] 1155766002241 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 1155766002242 active site 1155766002243 phosphorylation site [posttranslational modification] 1155766002244 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 1155766002245 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 1155766002246 active pocket/dimerization site; other site 1155766002247 active site 1155766002248 phosphorylation site [posttranslational modification] 1155766002249 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 1155766002250 active site 1155766002251 phosphorylation site [posttranslational modification] 1155766002252 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 1155766002253 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 1155766002254 Domain of unknown function (DUF956); Region: DUF956; pfam06115 1155766002255 Predicted membrane protein [Function unknown]; Region: COG2261 1155766002256 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1155766002257 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1155766002258 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1155766002259 active site 1155766002260 Asp23 family; Region: Asp23; pfam03780 1155766002261 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 1155766002262 putative RNA binding site [nucleotide binding]; other site 1155766002263 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14179 1155766002264 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1155766002265 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1155766002266 homodimer interface [polypeptide binding]; other site 1155766002267 NADP binding site [chemical binding]; other site 1155766002268 substrate binding site [chemical binding]; other site 1155766002269 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 1155766002270 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 1155766002271 generic binding surface II; other site 1155766002272 generic binding surface I; other site 1155766002273 Site-specific recombinase; Region: SpecificRecomb; cl15411 1155766002274 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 1155766002275 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1155766002276 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1155766002277 substrate binding pocket [chemical binding]; other site 1155766002278 chain length determination region; other site 1155766002279 substrate-Mg2+ binding site; other site 1155766002280 catalytic residues [active] 1155766002281 aspartate-rich region 1; other site 1155766002282 active site lid residues [active] 1155766002283 aspartate-rich region 2; other site 1155766002284 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 1155766002285 S4 RNA-binding domain; Region: S4; smart00363 1155766002286 RNA binding surface [nucleotide binding]; other site 1155766002287 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 1155766002288 Arginine repressor [Transcription]; Region: ArgR; COG1438 1155766002289 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1155766002290 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1155766002291 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 1155766002292 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1155766002293 Walker A/P-loop; other site 1155766002294 ATP binding site [chemical binding]; other site 1155766002295 Q-loop/lid; other site 1155766002296 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1155766002297 ABC transporter signature motif; other site 1155766002298 Walker B; other site 1155766002299 D-loop; other site 1155766002300 H-loop/switch region; other site 1155766002301 Protein of unknown function (DUF4044); Region: DUF4044; pfam13253 1155766002302 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 1155766002303 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 1155766002304 Cl binding site [ion binding]; other site 1155766002305 oligomer interface [polypeptide binding]; other site 1155766002306 Protein of unknown function (DUF3397); Region: DUF3397; pfam11877 1155766002307 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001 1155766002308 MraZ protein; Region: MraZ; pfam02381 1155766002309 MraZ protein; Region: MraZ; pfam02381 1155766002310 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 1155766002311 MraW methylase family; Region: Methyltransf_5; pfam01795 1155766002312 Cell division protein FtsL; Region: FtsL; cl11433 1155766002313 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1155766002314 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1155766002315 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1155766002316 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 1155766002317 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 1155766002318 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 1155766002319 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1155766002320 Mg++ binding site [ion binding]; other site 1155766002321 putative catalytic motif [active] 1155766002322 putative substrate binding site [chemical binding]; other site 1155766002323 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 1155766002324 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002 1155766002325 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1155766002326 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1155766002327 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 1155766002328 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1155766002329 active site 1155766002330 homodimer interface [polypeptide binding]; other site 1155766002331 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 1155766002332 Cell division protein FtsQ; Region: FtsQ; pfam03799 1155766002333 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 1155766002334 Cell division protein FtsA; Region: FtsA; smart00842 1155766002335 Cell division protein FtsA; Region: FtsA; pfam14450 1155766002336 Domain of unknown function (DUF3484); Region: DUF3484; pfam11983 1155766002337 cell division protein FtsZ; Validated; Region: PRK09330 1155766002338 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1155766002339 nucleotide binding site [chemical binding]; other site 1155766002340 SulA interaction site; other site 1155766002341 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 1155766002342 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1155766002343 catalytic residue [active] 1155766002344 Protein of unknown function (DUF552); Region: DUF552; pfam04472 1155766002345 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 1155766002346 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1155766002347 RNA binding surface [nucleotide binding]; other site 1155766002348 DivIVA protein; Region: DivIVA; pfam05103 1155766002349 DivIVA domain; Region: DivI1A_domain; TIGR03544 1155766002350 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 1155766002351 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 1155766002352 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1155766002353 active site 1155766002354 HIGH motif; other site 1155766002355 nucleotide binding site [chemical binding]; other site 1155766002356 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1155766002357 active site 1155766002358 KMSKS motif; other site 1155766002359 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 1155766002360 tRNA binding surface [nucleotide binding]; other site 1155766002361 anticodon binding site; other site 1155766002362 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1155766002363 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1155766002364 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1155766002365 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1155766002366 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 1155766002367 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 1155766002368 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1155766002369 FeoA domain; Region: FeoA; pfam04023 1155766002370 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 1155766002371 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1155766002372 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1155766002373 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1155766002374 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1155766002375 ATP binding site [chemical binding]; other site 1155766002376 putative Mg++ binding site [ion binding]; other site 1155766002377 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1155766002378 nucleotide binding region [chemical binding]; other site 1155766002379 ATP-binding site [chemical binding]; other site 1155766002380 potential frameshift: common BLAST hit: gi|29375591|ref|NP_814745.1| sigma-54 factor interaction domain-containing protein 1155766002381 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1155766002382 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 1155766002383 putative DNA binding site [nucleotide binding]; other site 1155766002384 putative Zn2+ binding site [ion binding]; other site 1155766002385 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1155766002386 Walker A motif; other site 1155766002387 ATP binding site [chemical binding]; other site 1155766002388 Walker B motif; other site 1155766002389 PRD domain; Region: PRD; pfam00874 1155766002390 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 1155766002391 active pocket/dimerization site; other site 1155766002392 active site 1155766002393 phosphorylation site [posttranslational modification] 1155766002394 PRD domain; Region: PRD; pfam00874 1155766002395 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 1155766002396 active site 1155766002397 P-loop; other site 1155766002398 phosphorylation site [posttranslational modification] 1155766002399 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 1155766002400 active site 1155766002401 methionine cluster; other site 1155766002402 phosphorylation site [posttranslational modification] 1155766002403 metal binding site [ion binding]; metal-binding site 1155766002404 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 1155766002405 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1155766002406 Protein of unknown function (DUF3188); Region: DUF3188; pfam11384 1155766002407 Domain of unknown function (DUF3284); Region: DUF3284; pfam11687 1155766002408 Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527 1155766002409 Predicted acetyltransferase involved in intracellular survival and related acetyltransferases [General function prediction only]; Region: Eis; COG4552 1155766002410 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 1155766002411 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 1155766002412 Int/Topo IB signature motif; other site 1155766002413 Short C-terminal domain; Region: SHOCT; pfam09851 1155766002414 Domain of unknown function (DUF1934); Region: DUF1934; cl01870 1155766002415 Domain of unknown function (DUF955); Region: DUF955; pfam06114 1155766002416 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1155766002417 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1155766002418 non-specific DNA binding site [nucleotide binding]; other site 1155766002419 salt bridge; other site 1155766002420 sequence-specific DNA binding site [nucleotide binding]; other site 1155766002421 Prophage antirepressor [Transcription]; Region: COG3617 1155766002422 BRO family, N-terminal domain; Region: Bro-N; smart01040 1155766002423 Phage antirepressor protein KilAC domain; Region: ANT; pfam03374 1155766002424 non-specific DNA binding site [nucleotide binding]; other site 1155766002425 salt bridge; other site 1155766002426 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 1155766002427 sequence-specific DNA binding site [nucleotide binding]; other site 1155766002428 Domain of unknown function (DUF771); Region: DUF771; pfam05595 1155766002429 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 1155766002430 ORF6C domain; Region: ORF6C; pfam10552 1155766002431 Protein of unknown function (DUF1071); Region: DUF1071; pfam06378 1155766002432 Protein of unknown function (DUF968); Region: DUF968; pfam06147 1155766002433 Helix-turn-helix domain; Region: HTH_36; pfam13730 1155766002434 Protein of unknown function (DUF1140); Region: DUF1140; pfam06600 1155766002435 YopX protein; Region: YopX; pfam09643 1155766002436 Protein of unknown function (DUF1642); Region: DUF1642; pfam07852 1155766002437 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 1155766002438 AAA ATPase containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: MDN1; COG5271 1155766002439 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1155766002440 active site 1155766002441 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 1155766002442 Phage portal protein; Region: Phage_portal; pfam04860 1155766002443 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 1155766002444 oligomer interface [polypeptide binding]; other site 1155766002445 active site residues [active] 1155766002446 Phage capsid family; Region: Phage_capsid; pfam05065 1155766002447 Phage-related minor tail protein [Function unknown]; Region: COG5280 1155766002448 membrane protein P6; Region: PHA01399 1155766002449 membrane protein P6; Region: PHA01399 1155766002450 Phage-related protein [Function unknown]; Region: COG4722 1155766002451 Phage tail protein; Region: Sipho_tail; cl17486 1155766002452 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 1155766002453 Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; Region: SPEC; cl02488 1155766002454 Phage uncharacterized protein (Phage_XkdX); Region: Phage_XkdX; pfam09693 1155766002455 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1155766002456 amidase catalytic site [active] 1155766002457 Zn binding residues [ion binding]; other site 1155766002458 substrate binding site [chemical binding]; other site 1155766002459 Transposase; Region: HTH_Tnp_1; pfam01527 1155766002460 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1155766002461 putative transposase OrfB; Reviewed; Region: PHA02517 1155766002462 Integrase core domain; Region: rve; pfam00665 1155766002463 Integrase core domain; Region: rve_3; pfam13683 1155766002464 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1155766002465 Helix-turn-helix domain; Region: HTH_28; pfam13518 1155766002466 Helix-turn-helix domain; Region: HTH_28; pfam13518 1155766002467 Winged helix-turn helix; Region: HTH_29; pfam13551 1155766002468 Homeodomain-like domain; Region: HTH_32; pfam13565 1155766002469 Predicted membrane protein [Function unknown]; Region: COG2261 1155766002470 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 1155766002471 glutamate:gamma-aminobutyrate antiporter; Region: 2A0307_GadC; TIGR00910 1155766002472 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 1155766002473 glutaminase A; Region: Gln_ase; TIGR03814 1155766002474 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK12315 1155766002475 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 1155766002476 TPP-binding site; other site 1155766002477 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1155766002478 PYR/PP interface [polypeptide binding]; other site 1155766002479 dimer interface [polypeptide binding]; other site 1155766002480 TPP binding site [chemical binding]; other site 1155766002481 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1155766002482 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 1155766002483 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 1155766002484 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 1155766002485 putative active site cavity [active] 1155766002486 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 1155766002487 Cell cycle protein; Region: FTSW_RODA_SPOVE; pfam01098 1155766002488 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1155766002489 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1155766002490 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 1155766002491 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1155766002492 Coenzyme A binding pocket [chemical binding]; other site 1155766002493 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 1155766002494 active site 1155766002495 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 1155766002496 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 1155766002497 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1155766002498 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1155766002499 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1155766002500 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 1155766002501 Uncharacterized protein conserved in bacteria (DUF2200); Region: DUF2200; pfam09966 1155766002502 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 1155766002503 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 1155766002504 catalytic residue [active] 1155766002505 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 1155766002506 catalytic residues [active] 1155766002507 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1155766002508 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1155766002509 peroxiredoxin; Region: AhpC; TIGR03137 1155766002510 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1155766002511 dimer interface [polypeptide binding]; other site 1155766002512 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1155766002513 catalytic triad [active] 1155766002514 peroxidatic and resolving cysteines [active] 1155766002515 DNA-binding transcriptional repressor UxuR; Provisional; Region: PRK10225 1155766002516 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1155766002517 DNA-binding site [nucleotide binding]; DNA binding site 1155766002518 FCD domain; Region: FCD; pfam07729 1155766002519 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 1155766002520 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1155766002521 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1155766002522 mannonate dehydratase; Provisional; Region: PRK03906 1155766002523 mannonate dehydratase; Region: uxuA; TIGR00695 1155766002524 Mga helix-turn-helix domain; Region: Mga; pfam05043 1155766002525 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 1155766002526 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1155766002527 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1155766002528 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1155766002529 MarR family; Region: MarR; pfam01047 1155766002530 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 1155766002531 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1155766002532 active site 1155766002533 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1155766002534 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1155766002535 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1155766002536 maltodextrin glucosidase; Provisional; Region: PRK10785 1155766002537 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 1155766002538 homodimer interface [polypeptide binding]; other site 1155766002539 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 1155766002540 active site 1155766002541 homodimer interface [polypeptide binding]; other site 1155766002542 catalytic site [active] 1155766002543 maltose ABC transporter periplasmic protein; Reviewed; Region: malE; PRK09474 1155766002544 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1155766002545 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1155766002546 dimer interface [polypeptide binding]; other site 1155766002547 conserved gate region; other site 1155766002548 putative PBP binding loops; other site 1155766002549 ABC-ATPase subunit interface; other site 1155766002550 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1155766002551 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1155766002552 dimer interface [polypeptide binding]; other site 1155766002553 conserved gate region; other site 1155766002554 putative PBP binding loops; other site 1155766002555 ABC-ATPase subunit interface; other site 1155766002556 Predicted integral membrane protein [Function unknown]; Region: COG5521 1155766002557 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 1155766002558 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1155766002559 S-adenosylmethionine binding site [chemical binding]; other site 1155766002560 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1155766002561 Predicted membrane protein [Function unknown]; Region: COG3212 1155766002562 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1155766002563 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 1155766002564 Dihydroorotate dehydrogenase (DHOD) class 1A FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1A_like; cd04741 1155766002565 active site 1155766002566 FMN binding site [chemical binding]; other site 1155766002567 substrate binding site [chemical binding]; other site 1155766002568 catalytic residues [active] 1155766002569 homodimer interface [polypeptide binding]; other site 1155766002570 amidase; Provisional; Region: PRK06529 1155766002571 Amidase; Region: Amidase; cl11426 1155766002572 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1155766002573 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1155766002574 substrate binding pocket [chemical binding]; other site 1155766002575 membrane-bound complex binding site; other site 1155766002576 hinge residues; other site 1155766002577 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1155766002578 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1155766002579 putative PBP binding loops; other site 1155766002580 dimer interface [polypeptide binding]; other site 1155766002581 ABC-ATPase subunit interface; other site 1155766002582 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1155766002583 Coenzyme A binding pocket [chemical binding]; other site 1155766002584 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1155766002585 Guanylate kinase; Region: Guanylate_kin; pfam00625 1155766002586 active site 1155766002587 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 1155766002588 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1155766002589 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1155766002590 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4868 1155766002591 Domain of unknown function (DUF1846); Region: DUF1846; pfam08903 1155766002592 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 1155766002593 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1155766002594 Cation efflux family; Region: Cation_efflux; pfam01545 1155766002595 AzlC protein; Region: AzlC; pfam03591 1155766002596 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 1155766002597 stage V sporulation protein B; Region: spore_V_B; TIGR02900 1155766002598 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 1155766002599 EDD domain protein, DegV family; Region: DegV; TIGR00762 1155766002600 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1155766002601 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 1155766002602 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1155766002603 Homeodomain-like domain; Region: HTH_23; pfam13384 1155766002604 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1155766002605 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1155766002606 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 1155766002607 metal ion-dependent adhesion site (MIDAS); other site 1155766002608 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1155766002609 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1155766002610 Ca binding site [ion binding]; other site 1155766002611 active site 1155766002612 catalytic site [active] 1155766002613 Protein of unknown function (DUF436); Region: DUF436; pfam04260 1155766002614 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; pfam07155 1155766002615 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1155766002616 dimer interface [polypeptide binding]; other site 1155766002617 substrate binding site [chemical binding]; other site 1155766002618 ATP binding site [chemical binding]; other site 1155766002619 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 1155766002620 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1155766002621 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1155766002622 acyl-activating enzyme (AAE) consensus motif; other site 1155766002623 acyl-activating enzyme (AAE) consensus motif; other site 1155766002624 AMP binding site [chemical binding]; other site 1155766002625 active site 1155766002626 CoA binding site [chemical binding]; other site 1155766002627 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1155766002628 active site 1155766002629 Int/Topo IB signature motif; other site 1155766002630 DNA binding site [nucleotide binding] 1155766002631 Heat induced stress protein YflT; Region: YflT; pfam11181 1155766002632 Domain of unknown function (DUF2382); Region: DUF2382; pfam09557 1155766002633 potential frameshift: common BLAST hit: gi|258538864|ref|YP_003173363.1| two component sensor transduction histidine kinase 1155766002634 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1155766002635 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1155766002636 ATP binding site [chemical binding]; other site 1155766002637 Mg2+ binding site [ion binding]; other site 1155766002638 G-X-G motif; other site 1155766002639 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1155766002640 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1155766002641 dimer interface [polypeptide binding]; other site 1155766002642 phosphorylation site [posttranslational modification] 1155766002643 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1155766002644 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1155766002645 active site 1155766002646 phosphorylation site [posttranslational modification] 1155766002647 intermolecular recognition site; other site 1155766002648 dimerization interface [polypeptide binding]; other site 1155766002649 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1155766002650 DNA binding site [nucleotide binding] 1155766002651 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1155766002652 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1155766002653 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1155766002654 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1155766002655 Walker A/P-loop; other site 1155766002656 ATP binding site [chemical binding]; other site 1155766002657 Q-loop/lid; other site 1155766002658 ABC transporter signature motif; other site 1155766002659 Walker B; other site 1155766002660 D-loop; other site 1155766002661 H-loop/switch region; other site 1155766002662 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1155766002663 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1155766002664 HTH domain; Region: HTH_11; pfam08279 1155766002665 Mga helix-turn-helix domain; Region: Mga; pfam05043 1155766002666 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 1155766002667 active site 1155766002668 P-loop; other site 1155766002669 phosphorylation site [posttranslational modification] 1155766002670 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1155766002671 metal ion-dependent adhesion site (MIDAS); other site 1155766002672 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 1155766002673 domain interaction interfaces [polypeptide binding]; other site 1155766002674 Cna protein B-type domain; Region: Cna_B; pfam05738 1155766002675 Cna protein B-type domain; Region: Cna_B; pfam05738 1155766002676 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 1155766002677 Cna protein B-type domain; Region: Cna_B; pfam05738 1155766002678 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 1155766002679 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 1155766002680 Cna protein B-type domain; Region: Cna_B; pfam05738 1155766002681 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 1155766002682 active site 1155766002683 catalytic site [active] 1155766002684 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1155766002685 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1155766002686 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1155766002687 putative active site [active] 1155766002688 putative oxidoreductase; Provisional; Region: PRK10206 1155766002689 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1155766002690 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1155766002691 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1155766002692 PRD domain; Region: PRD; pfam00874 1155766002693 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1155766002694 active site 1155766002695 P-loop; other site 1155766002696 phosphorylation site [posttranslational modification] 1155766002697 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1155766002698 active site 1155766002699 phosphorylation site [posttranslational modification] 1155766002700 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 1155766002701 active site 1155766002702 P-loop; other site 1155766002703 phosphorylation site [posttranslational modification] 1155766002704 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 1155766002705 potential frameshift: common BLAST hit: gi|254557930|ref|YP_003064347.1| alpha-L-rhamnosidase 1155766002706 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 1155766002707 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 1155766002708 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1155766002709 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1155766002710 putative substrate translocation pore; other site 1155766002711 Cupin domain; Region: Cupin_2; cl17218 1155766002712 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1155766002713 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1155766002714 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 1155766002715 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 1155766002716 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1155766002717 NAD binding site [chemical binding]; other site 1155766002718 dimer interface [polypeptide binding]; other site 1155766002719 substrate binding site [chemical binding]; other site 1155766002720 dif site (replication terminus) ; In Escherichia coli and Bacillus subtilis, changes in mutational bias patterns indicate that replicationtermination most likely occurs at or near the dif site. 1155766002721 Fic/DOC family; Region: Fic; cl00960 1155766002722 putative addiction module antidote; Region: doc_partner; TIGR02609 1155766002723 DNA topoisomerase III; Provisional; Region: PRK07726 1155766002724 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 1155766002725 active site 1155766002726 putative interdomain interaction site [polypeptide binding]; other site 1155766002727 putative metal-binding site [ion binding]; other site 1155766002728 putative nucleotide binding site [chemical binding]; other site 1155766002729 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1155766002730 domain I; other site 1155766002731 DNA binding groove [nucleotide binding] 1155766002732 phosphate binding site [ion binding]; other site 1155766002733 domain II; other site 1155766002734 domain III; other site 1155766002735 nucleotide binding site [chemical binding]; other site 1155766002736 catalytic site [active] 1155766002737 domain IV; other site 1155766002738 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 1155766002739 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1155766002740 dimer interface [polypeptide binding]; other site 1155766002741 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1155766002742 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816 1155766002743 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 1155766002744 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1155766002745 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1155766002746 shikimate binding site; other site 1155766002747 NAD(P) binding site [chemical binding]; other site 1155766002748 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 1155766002749 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1155766002750 Walker A/P-loop; other site 1155766002751 ATP binding site [chemical binding]; other site 1155766002752 Q-loop/lid; other site 1155766002753 ABC transporter signature motif; other site 1155766002754 Walker B; other site 1155766002755 D-loop; other site 1155766002756 H-loop/switch region; other site 1155766002757 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1155766002758 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 1155766002759 TM-ABC transporter signature motif; other site 1155766002760 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 1155766002761 zinc binding site [ion binding]; other site 1155766002762 putative ligand binding site [chemical binding]; other site 1155766002763 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1155766002764 Helix-turn-helix domain; Region: HTH_38; pfam13936 1155766002765 Integrase core domain; Region: rve; pfam00665 1155766002766 Integrase core domain; Region: rve_3; cl15866 1155766002767 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 1155766002768 Domain of unknown function (DUF814); Region: DUF814; pfam05670 1155766002769 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1155766002770 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1155766002771 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1155766002772 dimerization interface [polypeptide binding]; other site 1155766002773 Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124 1155766002774 active site 1155766002775 zinc binding site [ion binding]; other site 1155766002776 HD domain; Region: HD_3; cl17350 1155766002777 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1155766002778 active site 1155766002779 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1155766002780 active site 1155766002781 dimer interface [polypeptide binding]; other site 1155766002782 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 1155766002783 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 1155766002784 heterodimer interface [polypeptide binding]; other site 1155766002785 active site 1155766002786 FMN binding site [chemical binding]; other site 1155766002787 homodimer interface [polypeptide binding]; other site 1155766002788 substrate binding site [chemical binding]; other site 1155766002789 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 1155766002790 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 1155766002791 FAD binding pocket [chemical binding]; other site 1155766002792 FAD binding motif [chemical binding]; other site 1155766002793 phosphate binding motif [ion binding]; other site 1155766002794 beta-alpha-beta structure motif; other site 1155766002795 NAD binding pocket [chemical binding]; other site 1155766002796 Iron coordination center [ion binding]; other site 1155766002797 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1155766002798 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1155766002799 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1155766002800 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1155766002801 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1155766002802 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1155766002803 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 1155766002804 IMP binding site; other site 1155766002805 dimer interface [polypeptide binding]; other site 1155766002806 interdomain contacts; other site 1155766002807 partial ornithine binding site; other site 1155766002808 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1155766002809 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 1155766002810 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1155766002811 catalytic site [active] 1155766002812 subunit interface [polypeptide binding]; other site 1155766002813 dihydroorotase; Validated; Region: pyrC; PRK09357 1155766002814 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1155766002815 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 1155766002816 active site 1155766002817 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 1155766002818 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1155766002819 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1155766002820 uracil transporter; Provisional; Region: PRK10720 1155766002821 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 1155766002822 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1155766002823 active site 1155766002824 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 1155766002825 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1155766002826 RNA binding surface [nucleotide binding]; other site 1155766002827 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1155766002828 active site 1155766002829 lipoprotein signal peptidase; Provisional; Region: PRK14797 1155766002830 lipoprotein signal peptidase; Provisional; Region: PRK14787 1155766002831 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 1155766002832 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 1155766002833 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 1155766002834 Potassium binding sites [ion binding]; other site 1155766002835 Cesium cation binding sites [ion binding]; other site 1155766002836 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1155766002837 DNA-binding site [nucleotide binding]; DNA binding site 1155766002838 RNA-binding motif; other site 1155766002839 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 1155766002840 RNA/DNA hybrid binding site [nucleotide binding]; other site 1155766002841 active site 1155766002842 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1155766002843 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 1155766002844 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 1155766002845 Predicted membrane protein [Function unknown]; Region: COG4684 1155766002846 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1155766002847 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 1155766002848 motif 1; other site 1155766002849 active site 1155766002850 motif 2; other site 1155766002851 motif 3; other site 1155766002852 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1155766002853 DHHA1 domain; Region: DHHA1; pfam02272 1155766002854 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1155766002855 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1155766002856 Coenzyme A binding pocket [chemical binding]; other site 1155766002857 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 1155766002858 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1155766002859 ATP binding site [chemical binding]; other site 1155766002860 Mg++ binding site [ion binding]; other site 1155766002861 motif III; other site 1155766002862 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1155766002863 nucleotide binding region [chemical binding]; other site 1155766002864 ATP-binding site [chemical binding]; other site 1155766002865 VanZ like family; Region: VanZ; pfam04892 1155766002866 RDD family; Region: RDD; pfam06271 1155766002867 putative fructoselysine transporter; Provisional; Region: frlA; PRK11357 1155766002868 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1155766002869 L-threonine dehydrogenase, extended (e) SDRs; Region: TDH_SDR_e; cd05272 1155766002870 NAD binding site [chemical binding]; other site 1155766002871 homodimer interface [polypeptide binding]; other site 1155766002872 active site 1155766002873 putative substrate binding site [chemical binding]; other site 1155766002874 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1155766002875 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 1155766002876 substrate-cofactor binding pocket; other site 1155766002877 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1155766002878 catalytic residue [active] 1155766002879 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 1155766002880 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1155766002881 Zn2+ binding site [ion binding]; other site 1155766002882 Mg2+ binding site [ion binding]; other site 1155766002883 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 1155766002884 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 1155766002885 active site 1155766002886 Zn binding site [ion binding]; other site 1155766002887 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 1155766002888 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 1155766002889 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1155766002890 cell division protein GpsB; Provisional; Region: PRK14127 1155766002891 DivIVA domain; Region: DivI1A_domain; TIGR03544 1155766002892 hypothetical protein; Provisional; Region: PRK13660 1155766002893 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 1155766002894 Transglycosylase; Region: Transgly; pfam00912 1155766002895 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1155766002896 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1155766002897 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 1155766002898 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1155766002899 minor groove reading motif; other site 1155766002900 helix-hairpin-helix signature motif; other site 1155766002901 substrate binding pocket [chemical binding]; other site 1155766002902 active site 1155766002903 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 1155766002904 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 1155766002905 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 1155766002906 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1155766002907 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1155766002908 putative substrate translocation pore; other site 1155766002909 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1155766002910 MarR family; Region: MarR; pfam01047 1155766002911 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 1155766002912 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1155766002913 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1155766002914 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1155766002915 metal binding site 2 [ion binding]; metal-binding site 1155766002916 putative DNA binding helix; other site 1155766002917 metal binding site 1 [ion binding]; metal-binding site 1155766002918 dimer interface [polypeptide binding]; other site 1155766002919 structural Zn2+ binding site [ion binding]; other site 1155766002920 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1155766002921 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1155766002922 dimer interface [polypeptide binding]; other site 1155766002923 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1155766002924 catalytic residue [active] 1155766002925 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 1155766002926 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1155766002927 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1155766002928 Helix-turn-helix domain; Region: HTH_38; pfam13936 1155766002929 Integrase core domain; Region: rve; pfam00665 1155766002930 Integrase core domain; Region: rve_3; cl15866 1155766002931 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 1155766002932 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1155766002933 TPP-binding site [chemical binding]; other site 1155766002934 dimer interface [polypeptide binding]; other site 1155766002935 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1155766002936 PYR/PP interface [polypeptide binding]; other site 1155766002937 dimer interface [polypeptide binding]; other site 1155766002938 TPP binding site [chemical binding]; other site 1155766002939 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1155766002940 Bacterial protein of unknown function (DUF896); Region: DUF896; cl01722 1155766002941 LexA repressor; Validated; Region: PRK00215 1155766002942 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1155766002943 putative DNA binding site [nucleotide binding]; other site 1155766002944 putative Zn2+ binding site [ion binding]; other site 1155766002945 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1155766002946 Catalytic site [active] 1155766002947 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1155766002948 active site 1155766002949 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 1155766002950 DHH family; Region: DHH; pfam01368 1155766002951 DHHA1 domain; Region: DHHA1; pfam02272 1155766002952 Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; pfam10141 1155766002953 Protein of unknown function (DUF1049); Region: DUF1049; cl01539 1155766002954 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1155766002955 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1155766002956 NAD(P) binding site [chemical binding]; other site 1155766002957 active site 1155766002958 ribonuclease Z; Region: RNase_Z; TIGR02651 1155766002959 GTPase CgtA; Reviewed; Region: obgE; PRK12297 1155766002960 GTP1/OBG; Region: GTP1_OBG; pfam01018 1155766002961 Obg GTPase; Region: Obg; cd01898 1155766002962 G1 box; other site 1155766002963 GTP/Mg2+ binding site [chemical binding]; other site 1155766002964 Switch I region; other site 1155766002965 G2 box; other site 1155766002966 G3 box; other site 1155766002967 Switch II region; other site 1155766002968 G4 box; other site 1155766002969 G5 box; other site 1155766002970 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 1155766002971 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1155766002972 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 1155766002973 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1155766002974 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1155766002975 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1155766002976 Eukaryotic protein of unknown function (DUF829); Region: DUF829; pfam05705 1155766002977 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1155766002978 Helix-turn-helix domain; Region: HTH_38; pfam13936 1155766002979 Uncharacterized conserved protein [Function unknown]; Region: COG3589 1155766002980 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 1155766002981 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1155766002982 active site 1155766002983 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 1155766002984 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK06079 1155766002985 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 1155766002986 NAD binding site [chemical binding]; other site 1155766002987 homotetramer interface [polypeptide binding]; other site 1155766002988 homodimer interface [polypeptide binding]; other site 1155766002989 substrate binding site [chemical binding]; other site 1155766002990 active site 1155766002991 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 1155766002992 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1155766002993 homodimer interface [polypeptide binding]; other site 1155766002994 substrate-cofactor binding pocket; other site 1155766002995 catalytic residue [active] 1155766002996 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1155766002997 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1155766002998 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 1155766002999 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 1155766003000 active site 1155766003001 metal binding site [ion binding]; metal-binding site 1155766003002 homotetramer interface [polypeptide binding]; other site 1155766003003 ribonuclease PH; Reviewed; Region: rph; PRK00173 1155766003004 Ribonuclease PH; Region: RNase_PH_bact; cd11362 1155766003005 hexamer interface [polypeptide binding]; other site 1155766003006 active site 1155766003007 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1155766003008 active site 1155766003009 dimerization interface [polypeptide binding]; other site 1155766003010 glutamate racemase; Provisional; Region: PRK00865 1155766003011 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1155766003012 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1155766003013 dimer interface [polypeptide binding]; other site 1155766003014 conserved gate region; other site 1155766003015 putative PBP binding loops; other site 1155766003016 ABC-ATPase subunit interface; other site 1155766003017 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1155766003018 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1155766003019 dimer interface [polypeptide binding]; other site 1155766003020 conserved gate region; other site 1155766003021 putative PBP binding loops; other site 1155766003022 ABC-ATPase subunit interface; other site 1155766003023 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1155766003024 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1155766003025 substrate binding pocket [chemical binding]; other site 1155766003026 membrane-bound complex binding site; other site 1155766003027 hinge residues; other site 1155766003028 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1155766003029 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1155766003030 Walker A/P-loop; other site 1155766003031 ATP binding site [chemical binding]; other site 1155766003032 Q-loop/lid; other site 1155766003033 ABC transporter signature motif; other site 1155766003034 Walker B; other site 1155766003035 D-loop; other site 1155766003036 H-loop/switch region; other site 1155766003037 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1155766003038 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1155766003039 active site 1155766003040 HIGH motif; other site 1155766003041 dimer interface [polypeptide binding]; other site 1155766003042 KMSKS motif; other site 1155766003043 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1155766003044 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1155766003045 putative tRNA-binding site [nucleotide binding]; other site 1155766003046 B3/4 domain; Region: B3_4; pfam03483 1155766003047 tRNA synthetase B5 domain; Region: B5; smart00874 1155766003048 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1155766003049 dimer interface [polypeptide binding]; other site 1155766003050 motif 1; other site 1155766003051 motif 3; other site 1155766003052 motif 2; other site 1155766003053 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 1155766003054 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1155766003055 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1155766003056 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1155766003057 dimer interface [polypeptide binding]; other site 1155766003058 motif 1; other site 1155766003059 active site 1155766003060 motif 2; other site 1155766003061 motif 3; other site 1155766003062 Predicted transcriptional regulators [Transcription]; Region: COG1733 1155766003063 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1155766003064 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 1155766003065 Part of AAA domain; Region: AAA_19; pfam13245 1155766003066 Family description; Region: UvrD_C_2; pfam13538 1155766003067 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1155766003068 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 1155766003069 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1155766003070 VWFA-related Acidobacterial domain; Region: acidobact_VWFA; TIGR03436 1155766003071 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1155766003072 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1155766003073 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 1155766003074 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1155766003075 putative substrate translocation pore; other site 1155766003076 POT family; Region: PTR2; cl17359 1155766003077 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 1155766003078 dimer interface [polypeptide binding]; other site 1155766003079 FMN binding site [chemical binding]; other site 1155766003080 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 1155766003081 putative active site [active] 1155766003082 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 1155766003083 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1155766003084 Ligand Binding Site [chemical binding]; other site 1155766003085 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1155766003086 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1155766003087 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1155766003088 Coenzyme A binding pocket [chemical binding]; other site 1155766003089 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 1155766003090 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1155766003091 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1155766003092 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1155766003093 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1155766003094 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 1155766003095 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 1155766003096 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 1155766003097 DEAD/DEAH box helicase; Region: DEAD; pfam00270 1155766003098 DEAD_2; Region: DEAD_2; pfam06733 1155766003099 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1155766003100 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1155766003101 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1155766003102 catalytic core [active] 1155766003103 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 1155766003104 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 1155766003105 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1155766003106 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1155766003107 Protein of unknown function (DUF441); Region: DUF441; pfam04284 1155766003108 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 1155766003109 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 1155766003110 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 1155766003111 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 1155766003112 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 1155766003113 Competence protein; Region: Competence; pfam03772 1155766003114 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 1155766003115 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1155766003116 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 1155766003117 catalytic motif [active] 1155766003118 Zn binding site [ion binding]; other site 1155766003119 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1155766003120 GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472 1155766003121 oxyanion hole [active] 1155766003122 SLBB domain; Region: SLBB; pfam10531 1155766003123 comEA protein; Region: comE; TIGR01259 1155766003124 Helix-hairpin-helix motif; Region: HHH; pfam00633 1155766003125 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 1155766003126 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 1155766003127 protein binding site [polypeptide binding]; other site 1155766003128 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1155766003129 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1155766003130 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1155766003131 active site 1155766003132 (T/H)XGH motif; other site 1155766003133 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 1155766003134 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1155766003135 S-adenosylmethionine binding site [chemical binding]; other site 1155766003136 Uncharacterized protein conserved in bacteria (DUF2129); Region: DUF2129; pfam09902 1155766003137 Protein of unknown function (DUF964); Region: DUF964; pfam06133 1155766003138 pyruvate carboxylase; Reviewed; Region: PRK12999 1155766003139 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1155766003140 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1155766003141 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1155766003142 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 1155766003143 active site 1155766003144 catalytic residues [active] 1155766003145 metal binding site [ion binding]; metal-binding site 1155766003146 homodimer binding site [polypeptide binding]; other site 1155766003147 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1155766003148 carboxyltransferase (CT) interaction site; other site 1155766003149 biotinylation site [posttranslational modification]; other site 1155766003150 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 1155766003151 Protein of unknown function (DUF1507); Region: DUF1507; pfam07408 1155766003152 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 1155766003153 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1155766003154 ATP binding site [chemical binding]; other site 1155766003155 putative Mg++ binding site [ion binding]; other site 1155766003156 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1155766003157 nucleotide binding region [chemical binding]; other site 1155766003158 ATP-binding site [chemical binding]; other site 1155766003159 RQC domain; Region: RQC; pfam09382 1155766003160 HRDC domain; Region: HRDC; pfam00570 1155766003161 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 1155766003162 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 1155766003163 G1 box; other site 1155766003164 putative GEF interaction site [polypeptide binding]; other site 1155766003165 GTP/Mg2+ binding site [chemical binding]; other site 1155766003166 Switch I region; other site 1155766003167 G2 box; other site 1155766003168 G3 box; other site 1155766003169 Switch II region; other site 1155766003170 G4 box; other site 1155766003171 G5 box; other site 1155766003172 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1155766003173 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1155766003174 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1155766003175 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 1155766003176 active site 1155766003177 hypothetical protein; Provisional; Region: PRK04387 1155766003178 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 1155766003179 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 1155766003180 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1155766003181 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1155766003182 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 1155766003183 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1155766003184 E3 interaction surface; other site 1155766003185 lipoyl attachment site [posttranslational modification]; other site 1155766003186 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1155766003187 E3 interaction surface; other site 1155766003188 lipoyl attachment site [posttranslational modification]; other site 1155766003189 e3 binding domain; Region: E3_binding; pfam02817 1155766003190 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1155766003191 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1155766003192 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1155766003193 alpha subunit interface [polypeptide binding]; other site 1155766003194 TPP binding site [chemical binding]; other site 1155766003195 heterodimer interface [polypeptide binding]; other site 1155766003196 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1155766003197 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 1155766003198 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1155766003199 tetramer interface [polypeptide binding]; other site 1155766003200 TPP-binding site [chemical binding]; other site 1155766003201 heterodimer interface [polypeptide binding]; other site 1155766003202 phosphorylation loop region [posttranslational modification] 1155766003203 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1155766003204 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1155766003205 DNA-binding site [nucleotide binding]; DNA binding site 1155766003206 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1155766003207 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1155766003208 homodimer interface [polypeptide binding]; other site 1155766003209 catalytic residue [active] 1155766003210 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 1155766003211 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1155766003212 active site 1155766003213 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1155766003214 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1155766003215 TM-ABC transporter signature motif; other site 1155766003216 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1155766003217 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1155766003218 Walker A/P-loop; other site 1155766003219 ATP binding site [chemical binding]; other site 1155766003220 Q-loop/lid; other site 1155766003221 ABC transporter signature motif; other site 1155766003222 Walker B; other site 1155766003223 D-loop; other site 1155766003224 H-loop/switch region; other site 1155766003225 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1155766003226 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 1155766003227 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 1155766003228 putative ligand binding site [chemical binding]; other site 1155766003229 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 1155766003230 Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309 1155766003231 putative ligand binding site [chemical binding]; other site 1155766003232 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1155766003233 Histidine kinase; Region: His_kinase; pfam06580 1155766003234 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1155766003235 ATP binding site [chemical binding]; other site 1155766003236 Mg2+ binding site [ion binding]; other site 1155766003237 G-X-G motif; other site 1155766003238 Response regulator receiver domain; Region: Response_reg; pfam00072 1155766003239 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1155766003240 active site 1155766003241 phosphorylation site [posttranslational modification] 1155766003242 intermolecular recognition site; other site 1155766003243 dimerization interface [polypeptide binding]; other site 1155766003244 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1155766003245 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1155766003246 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1155766003247 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1155766003248 active site 1155766003249 catalytic tetrad [active] 1155766003250 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 1155766003251 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1155766003252 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 1155766003253 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 1155766003254 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 1155766003255 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1155766003256 purine monophosphate binding site [chemical binding]; other site 1155766003257 dimer interface [polypeptide binding]; other site 1155766003258 putative catalytic residues [active] 1155766003259 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 1155766003260 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 1155766003261 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 1155766003262 active site 1155766003263 substrate binding site [chemical binding]; other site 1155766003264 cosubstrate binding site; other site 1155766003265 catalytic site [active] 1155766003266 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 1155766003267 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 1155766003268 dimerization interface [polypeptide binding]; other site 1155766003269 putative ATP binding site [chemical binding]; other site 1155766003270 amidophosphoribosyltransferase; Provisional; Region: PRK07272 1155766003271 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 1155766003272 active site 1155766003273 tetramer interface [polypeptide binding]; other site 1155766003274 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1155766003275 active site 1155766003276 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 1155766003277 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 1155766003278 dimerization interface [polypeptide binding]; other site 1155766003279 ATP binding site [chemical binding]; other site 1155766003280 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 1155766003281 dimerization interface [polypeptide binding]; other site 1155766003282 ATP binding site [chemical binding]; other site 1155766003283 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 1155766003284 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 1155766003285 putative active site [active] 1155766003286 catalytic triad [active] 1155766003287 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700 1155766003288 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 1155766003289 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 1155766003290 ATP binding site [chemical binding]; other site 1155766003291 active site 1155766003292 substrate binding site [chemical binding]; other site 1155766003293 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1155766003294 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1155766003295 adenylosuccinate lyase; Provisional; Region: PRK07492 1155766003296 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 1155766003297 tetramer interface [polypeptide binding]; other site 1155766003298 active site 1155766003299 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1155766003300 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 1155766003301 NAD binding site [chemical binding]; other site 1155766003302 ATP-grasp domain; Region: ATP-grasp; pfam02222 1155766003303 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 1155766003304 xanthine permease; Region: pbuX; TIGR03173 1155766003305 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1155766003306 active site 1155766003307 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1155766003308 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1155766003309 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1155766003310 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1155766003311 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1155766003312 dimer interface [polypeptide binding]; other site 1155766003313 conserved gate region; other site 1155766003314 putative PBP binding loops; other site 1155766003315 ABC-ATPase subunit interface; other site 1155766003316 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1155766003317 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1155766003318 dimer interface [polypeptide binding]; other site 1155766003319 conserved gate region; other site 1155766003320 putative PBP binding loops; other site 1155766003321 ABC-ATPase subunit interface; other site 1155766003322 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1155766003323 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1155766003324 Class I aldolases; Region: Aldolase_Class_I; cl17187 1155766003325 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1155766003326 phosphate binding site [ion binding]; other site 1155766003327 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 1155766003328 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 1155766003329 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1155766003330 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1155766003331 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1155766003332 Predicted membrane protein [Function unknown]; Region: COG4129 1155766003333 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 1155766003334 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 1155766003335 Predicted membrane protein [Function unknown]; Region: COG4129 1155766003336 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 1155766003337 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 1155766003338 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 1155766003339 prohibitin homologues; Region: PHB; smart00244 1155766003340 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 1155766003341 potential frameshift: common BLAST hit: gi|379726772|ref|YP_005318957.1| two-component sensor histidine kinase, malate 1155766003342 sensory histidine kinase DcuS; Provisional; Region: PRK11086 1155766003343 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1155766003344 ATP binding site [chemical binding]; other site 1155766003345 Mg2+ binding site [ion binding]; other site 1155766003346 G-X-G motif; other site 1155766003347 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 1155766003348 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1155766003349 active site 1155766003350 phosphorylation site [posttranslational modification] 1155766003351 intermolecular recognition site; other site 1155766003352 dimerization interface [polypeptide binding]; other site 1155766003353 (R)-2-Hydroxyglutarate Dehydrogenase and related dehydrogenases, NAD-binding and catalytic domains; Region: HGDH_like; cd12184 1155766003354 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1155766003355 putative homodimer interface [polypeptide binding]; other site 1155766003356 putative ligand binding site [chemical binding]; other site 1155766003357 putative NAD binding site [chemical binding]; other site 1155766003358 catalytic site [active] 1155766003359 Membrane transport protein; Region: Mem_trans; cl09117 1155766003360 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 1155766003361 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 1155766003362 active site 1155766003363 dimer interface [polypeptide binding]; other site 1155766003364 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1155766003365 non-specific DNA binding site [nucleotide binding]; other site 1155766003366 salt bridge; other site 1155766003367 sequence-specific DNA binding site [nucleotide binding]; other site 1155766003368 aminotransferase AlaT; Validated; Region: PRK09265 1155766003369 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1155766003370 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1155766003371 homodimer interface [polypeptide binding]; other site 1155766003372 catalytic residue [active] 1155766003373 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1155766003374 MULE transposase domain; Region: MULE; pfam10551 1155766003375 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1155766003376 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 1155766003377 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1155766003378 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 1155766003379 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1155766003380 active site 1155766003381 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1155766003382 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1155766003383 Walker A/P-loop; other site 1155766003384 ATP binding site [chemical binding]; other site 1155766003385 Q-loop/lid; other site 1155766003386 ABC transporter signature motif; other site 1155766003387 Walker B; other site 1155766003388 D-loop; other site 1155766003389 H-loop/switch region; other site 1155766003390 NMT1/THI5 like; Region: NMT1; pfam09084 1155766003391 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 1155766003392 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1155766003393 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1155766003394 dimer interface [polypeptide binding]; other site 1155766003395 conserved gate region; other site 1155766003396 putative PBP binding loops; other site 1155766003397 ABC-ATPase subunit interface; other site 1155766003398 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 1155766003399 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1155766003400 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1155766003401 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1155766003402 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 1155766003403 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1155766003404 Walker A/P-loop; other site 1155766003405 ATP binding site [chemical binding]; other site 1155766003406 Q-loop/lid; other site 1155766003407 ABC transporter signature motif; other site 1155766003408 Walker B; other site 1155766003409 D-loop; other site 1155766003410 H-loop/switch region; other site 1155766003411 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1155766003412 dimer interface [polypeptide binding]; other site 1155766003413 conserved gate region; other site 1155766003414 ABC-ATPase subunit interface; other site 1155766003415 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 1155766003416 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 1155766003417 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1155766003418 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1155766003419 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1155766003420 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1155766003421 DNA binding site [nucleotide binding] 1155766003422 domain linker motif; other site 1155766003423 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1155766003424 ligand binding site [chemical binding]; other site 1155766003425 dimerization interface [polypeptide binding]; other site 1155766003426 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1155766003427 hypothetical protein; Provisional; Region: PRK04164 1155766003428 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1155766003429 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 1155766003430 Domain of unknown function (DUF1803); Region: DUF1803; pfam08820 1155766003431 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 1155766003432 DHH family; Region: DHH; pfam01368 1155766003433 DHHA2 domain; Region: DHHA2; pfam02833 1155766003434 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 1155766003435 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1155766003436 FeS/SAM binding site; other site 1155766003437 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 1155766003438 Pyruvate formate lyase 1; Region: PFL1; cd01678 1155766003439 coenzyme A binding site [chemical binding]; other site 1155766003440 active site 1155766003441 catalytic residues [active] 1155766003442 glycine loop; other site 1155766003443 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 1155766003444 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1155766003445 CAP-like domain; other site 1155766003446 active site 1155766003447 primary dimer interface [polypeptide binding]; other site 1155766003448 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1155766003449 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1155766003450 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 1155766003451 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1155766003452 ATP binding site [chemical binding]; other site 1155766003453 Mg2+ binding site [ion binding]; other site 1155766003454 G-X-G motif; other site 1155766003455 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1155766003456 anchoring element; other site 1155766003457 dimer interface [polypeptide binding]; other site 1155766003458 ATP binding site [chemical binding]; other site 1155766003459 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1155766003460 active site 1155766003461 putative metal-binding site [ion binding]; other site 1155766003462 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1155766003463 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 1155766003464 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 1155766003465 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 1155766003466 active site 1155766003467 catalytic residues [active] 1155766003468 transcriptional repressor CodY; Validated; Region: PRK04158 1155766003469 CodY GAF-like domain; Region: CodY; pfam06018 1155766003470 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1155766003471 putative DNA binding site [nucleotide binding]; other site 1155766003472 putative Zn2+ binding site [ion binding]; other site 1155766003473 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 1155766003474 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 1155766003475 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1155766003476 Walker A motif; other site 1155766003477 ATP binding site [chemical binding]; other site 1155766003478 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 1155766003479 Walker B motif; other site 1155766003480 arginine finger; other site 1155766003481 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1155766003482 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 1155766003483 active site 1155766003484 HslU subunit interaction site [polypeptide binding]; other site 1155766003485 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 1155766003486 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 1155766003487 active site 1155766003488 Int/Topo IB signature motif; other site 1155766003489 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 1155766003490 Glucose inhibited division protein A; Region: GIDA; pfam01134 1155766003491 DNA topoisomerase I; Validated; Region: PRK05582 1155766003492 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1155766003493 active site 1155766003494 interdomain interaction site; other site 1155766003495 putative metal-binding site [ion binding]; other site 1155766003496 nucleotide binding site [chemical binding]; other site 1155766003497 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1155766003498 domain I; other site 1155766003499 DNA binding groove [nucleotide binding] 1155766003500 phosphate binding site [ion binding]; other site 1155766003501 domain II; other site 1155766003502 domain III; other site 1155766003503 nucleotide binding site [chemical binding]; other site 1155766003504 catalytic site [active] 1155766003505 domain IV; other site 1155766003506 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1155766003507 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1155766003508 DNA protecting protein DprA; Region: dprA; TIGR00732 1155766003509 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 1155766003510 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1155766003511 RNA/DNA hybrid binding site [nucleotide binding]; other site 1155766003512 active site 1155766003513 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 1155766003514 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 1155766003515 GTP/Mg2+ binding site [chemical binding]; other site 1155766003516 G4 box; other site 1155766003517 G5 box; other site 1155766003518 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 1155766003519 G1 box; other site 1155766003520 G1 box; other site 1155766003521 GTP/Mg2+ binding site [chemical binding]; other site 1155766003522 Switch I region; other site 1155766003523 G2 box; other site 1155766003524 G2 box; other site 1155766003525 G3 box; other site 1155766003526 G3 box; other site 1155766003527 Switch II region; other site 1155766003528 Switch II region; other site 1155766003529 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 1155766003530 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1155766003531 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 1155766003532 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1155766003533 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462 1155766003534 Catalytic site [active] 1155766003535 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465 1155766003536 hypothetical protein; Provisional; Region: PRK13672 1155766003537 methionine sulfoxide reductase A; Provisional; Region: PRK14054 1155766003538 Uncharacterized protein conserved in bacteria (DUF2140); Region: DUF2140; pfam09911 1155766003539 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 1155766003540 active site 1155766003541 catalytic triad [active] 1155766003542 oxyanion hole [active] 1155766003543 EDD domain protein, DegV family; Region: DegV; TIGR00762 1155766003544 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1155766003545 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 1155766003546 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 1155766003547 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1155766003548 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1155766003549 folate binding site [chemical binding]; other site 1155766003550 NADP+ binding site [chemical binding]; other site 1155766003551 thymidylate synthase; Region: thym_sym; TIGR03284 1155766003552 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1155766003553 dimerization interface [polypeptide binding]; other site 1155766003554 active site 1155766003555 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1155766003556 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1155766003557 Walker A/P-loop; other site 1155766003558 ATP binding site [chemical binding]; other site 1155766003559 Q-loop/lid; other site 1155766003560 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1155766003561 ABC transporter signature motif; other site 1155766003562 Walker B; other site 1155766003563 D-loop; other site 1155766003564 ABC transporter; Region: ABC_tran_2; pfam12848 1155766003565 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1155766003566 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 1155766003567 acyl-CoA synthetase; Provisional; Region: PTZ00216 1155766003568 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 1155766003569 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1155766003570 active site 1155766003571 NTP binding site [chemical binding]; other site 1155766003572 metal binding triad [ion binding]; metal-binding site 1155766003573 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1155766003574 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 1155766003575 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531 1155766003576 homodimer interface [polypeptide binding]; other site 1155766003577 metal binding site [ion binding]; metal-binding site 1155766003578 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1155766003579 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1155766003580 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1155766003581 hypothetical protein; Provisional; Region: PRK03636 1155766003582 UPF0302 domain; Region: UPF0302; pfam08864 1155766003583 IDEAL domain; Region: IDEAL; pfam08858 1155766003584 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1155766003585 TPR motif; other site 1155766003586 binding surface 1155766003587 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1155766003588 binding surface 1155766003589 TPR motif; other site 1155766003590 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1155766003591 IHF dimer interface [polypeptide binding]; other site 1155766003592 IHF - DNA interface [nucleotide binding]; other site 1155766003593 GTP-binding protein Der; Reviewed; Region: PRK00093 1155766003594 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1155766003595 G1 box; other site 1155766003596 GTP/Mg2+ binding site [chemical binding]; other site 1155766003597 Switch I region; other site 1155766003598 G2 box; other site 1155766003599 Switch II region; other site 1155766003600 G3 box; other site 1155766003601 G4 box; other site 1155766003602 G5 box; other site 1155766003603 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1155766003604 G1 box; other site 1155766003605 GTP/Mg2+ binding site [chemical binding]; other site 1155766003606 Switch I region; other site 1155766003607 G2 box; other site 1155766003608 G3 box; other site 1155766003609 Switch II region; other site 1155766003610 G4 box; other site 1155766003611 G5 box; other site 1155766003612 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 1155766003613 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1155766003614 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 1155766003615 RNA binding site [nucleotide binding]; other site 1155766003616 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 1155766003617 RNA binding site [nucleotide binding]; other site 1155766003618 cytidylate kinase; Provisional; Region: cmk; PRK00023 1155766003619 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1155766003620 CMP-binding site; other site 1155766003621 The sites determining sugar specificity; other site 1155766003622 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1155766003623 ATP-dependent DNA helicase, RecQ family; Region: recQ_fam; TIGR00614 1155766003624 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1155766003625 ATP binding site [chemical binding]; other site 1155766003626 putative Mg++ binding site [ion binding]; other site 1155766003627 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1155766003628 nucleotide binding region [chemical binding]; other site 1155766003629 ATP-binding site [chemical binding]; other site 1155766003630 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 1155766003631 4Fe-4S single cluster domain; Region: Fer4_13; pfam13370 1155766003632 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1155766003633 hypothetical protein; Provisional; Region: PRK07205 1155766003634 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 1155766003635 active site 1155766003636 metal binding site [ion binding]; metal-binding site 1155766003637 Predicted membrane protein [Function unknown]; Region: COG1288 1155766003638 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 1155766003639 Predicted membrane protein [Function unknown]; Region: COG3601 1155766003640 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 1155766003641 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1155766003642 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1155766003643 RNA binding surface [nucleotide binding]; other site 1155766003644 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 1155766003645 active site 1155766003646 segregation and condensation protein B; Reviewed; Region: scpB; PRK00135 1155766003647 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 1155766003648 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 1155766003649 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 1155766003650 active site 1155766003651 Int/Topo IB signature motif; other site 1155766003652 ferric uptake regulator; Provisional; Region: fur; PRK09462 1155766003653 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1155766003654 metal binding site 2 [ion binding]; metal-binding site 1155766003655 putative DNA binding helix; other site 1155766003656 metal binding site 1 [ion binding]; metal-binding site 1155766003657 dimer interface [polypeptide binding]; other site 1155766003658 structural Zn2+ binding site [ion binding]; other site 1155766003659 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 1155766003660 S1 domain; Region: S1_2; pfam13509 1155766003661 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 1155766003662 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 1155766003663 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 1155766003664 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1155766003665 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1155766003666 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1155766003667 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1155766003668 DNA binding residues [nucleotide binding] 1155766003669 DNA primase; Validated; Region: dnaG; PRK05667 1155766003670 CHC2 zinc finger; Region: zf-CHC2; pfam01807 1155766003671 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1155766003672 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1155766003673 active site 1155766003674 metal binding site [ion binding]; metal-binding site 1155766003675 interdomain interaction site; other site 1155766003676 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 1155766003677 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1155766003678 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1155766003679 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1155766003680 motif II; other site 1155766003681 Domain of unknown function (DUF368); Region: DUF368; cl00893 1155766003682 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1155766003683 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1155766003684 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1155766003685 catalytic residue [active] 1155766003686 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1155766003687 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1155766003688 Predicted integral membrane protein [Function unknown]; Region: COG0392 1155766003689 Uncharacterized conserved protein [Function unknown]; Region: COG2898 1155766003690 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 1155766003691 elongation factor Tu; Reviewed; Region: PRK00049 1155766003692 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1155766003693 G1 box; other site 1155766003694 GEF interaction site [polypeptide binding]; other site 1155766003695 GTP/Mg2+ binding site [chemical binding]; other site 1155766003696 Switch I region; other site 1155766003697 G2 box; other site 1155766003698 G3 box; other site 1155766003699 Switch II region; other site 1155766003700 G4 box; other site 1155766003701 G5 box; other site 1155766003702 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1155766003703 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1155766003704 Antibiotic Binding Site [chemical binding]; other site 1155766003705 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 1155766003706 37-kD nucleoid-associated bacterial protein; Region: NA37; pfam04245 1155766003707 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1155766003708 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1155766003709 active site 1155766003710 catalytic tetrad [active] 1155766003711 putative acyltransferase; Provisional; Region: PRK05790 1155766003712 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1155766003713 dimer interface [polypeptide binding]; other site 1155766003714 active site 1155766003715 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 1155766003716 homodimer interface [polypeptide binding]; other site 1155766003717 catalytic residues [active] 1155766003718 NAD binding site [chemical binding]; other site 1155766003719 substrate binding pocket [chemical binding]; other site 1155766003720 flexible flap; other site 1155766003721 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 1155766003722 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835 1155766003723 dimer interface [polypeptide binding]; other site 1155766003724 active site 1155766003725 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1155766003726 S-adenosylmethionine binding site [chemical binding]; other site 1155766003727 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 1155766003728 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1155766003729 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1155766003730 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1155766003731 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 1155766003732 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1155766003733 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 1155766003734 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 1155766003735 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1155766003736 putative active site [active] 1155766003737 catalytic site [active] 1155766003738 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 1155766003739 putative active site [active] 1155766003740 catalytic site [active] 1155766003741 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1155766003742 dimer interface [polypeptide binding]; other site 1155766003743 substrate binding site [chemical binding]; other site 1155766003744 ATP binding site [chemical binding]; other site 1155766003745 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 1155766003746 putative catalytic residues [active] 1155766003747 thiol/disulfide switch; other site 1155766003748 ArsC family; Region: ArsC; pfam03960 1155766003749 Predicted transcriptional regulators [Transcription]; Region: COG1695 1155766003750 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1155766003751 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1155766003752 Ligand Binding Site [chemical binding]; other site 1155766003753 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 1155766003754 beta-galactosidase; Region: BGL; TIGR03356 1155766003755 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 1155766003756 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1155766003757 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1155766003758 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1155766003759 DNA-binding site [nucleotide binding]; DNA binding site 1155766003760 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 1155766003761 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 1155766003762 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1155766003763 Zn binding site [ion binding]; other site 1155766003764 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 1155766003765 Zn binding site [ion binding]; other site 1155766003766 Predicted esterase [General function prediction only]; Region: COG0400 1155766003767 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 1155766003768 active site 1155766003769 intersubunit interface [polypeptide binding]; other site 1155766003770 Zn2+ binding site [ion binding]; other site 1155766003771 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 1155766003772 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 1155766003773 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 1155766003774 active site 1155766003775 P-loop; other site 1155766003776 phosphorylation site [posttranslational modification] 1155766003777 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1155766003778 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1155766003779 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1155766003780 PRD domain protein EF_0829/AHA_3910; Region: EF_0829; TIGR03582 1155766003781 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1155766003782 HTH domain; Region: HTH_11; pfam08279 1155766003783 HTH domain; Region: HTH_11; cl17392 1155766003784 PRD domain; Region: PRD; pfam00874 1155766003785 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1155766003786 active site 1155766003787 P-loop; other site 1155766003788 phosphorylation site [posttranslational modification] 1155766003789 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1155766003790 Helix-turn-helix domain; Region: HTH_38; pfam13936 1155766003791 Integrase core domain; Region: rve; pfam00665 1155766003792 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1155766003793 MULE transposase domain; Region: MULE; pfam10551 1155766003794 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1155766003795 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1155766003796 Coenzyme A binding pocket [chemical binding]; other site 1155766003797 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1155766003798 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 1155766003799 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 1155766003800 intersubunit interface [polypeptide binding]; other site 1155766003801 active site 1155766003802 Zn2+ binding site [ion binding]; other site 1155766003803 putative L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13210 1155766003804 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1155766003805 AP (apurinic/apyrimidinic) site pocket; other site 1155766003806 DNA interaction; other site 1155766003807 Metal-binding active site; metal-binding site 1155766003808 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 1155766003809 active site 1155766003810 dimer interface [polypeptide binding]; other site 1155766003811 magnesium binding site [ion binding]; other site 1155766003812 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 1155766003813 active site 1155766003814 P-loop; other site 1155766003815 phosphorylation site [posttranslational modification] 1155766003816 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 1155766003817 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1155766003818 active site 1155766003819 phosphorylation site [posttranslational modification] 1155766003820 putative L-ascorbate 6-phosphate lactonase; Provisional; Region: PRK11709 1155766003821 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1155766003822 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1155766003823 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 1155766003824 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1155766003825 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1155766003826 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1155766003827 non-specific DNA binding site [nucleotide binding]; other site 1155766003828 salt bridge; other site 1155766003829 sequence-specific DNA binding site [nucleotide binding]; other site 1155766003830 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1155766003831 binding surface 1155766003832 TPR motif; other site 1155766003833 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1155766003834 TPR repeat; Region: TPR_11; pfam13414 1155766003835 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 1155766003836 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1155766003837 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 1155766003838 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1155766003839 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 1155766003840 HPr interaction site; other site 1155766003841 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1155766003842 active site 1155766003843 phosphorylation site [posttranslational modification] 1155766003844 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 1155766003845 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 1155766003846 NAD(P) binding site [chemical binding]; other site 1155766003847 LDH/MDH dimer interface [polypeptide binding]; other site 1155766003848 substrate binding site [chemical binding]; other site 1155766003849 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 1155766003850 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1155766003851 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1155766003852 active site turn [active] 1155766003853 phosphorylation site [posttranslational modification] 1155766003854 Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803 1155766003855 putative active site [active] 1155766003856 YdjC motif; other site 1155766003857 Mg binding site [ion binding]; other site 1155766003858 putative homodimer interface [polypeptide binding]; other site 1155766003859 transcriptional antiterminator BglG; Provisional; Region: PRK09772 1155766003860 CAT RNA binding domain; Region: CAT_RBD; smart01061 1155766003861 PRD domain; Region: PRD; pfam00874 1155766003862 PRD domain; Region: PRD; pfam00874 1155766003863 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1155766003864 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1155766003865 dimerization interface [polypeptide binding]; other site 1155766003866 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1155766003867 dimer interface [polypeptide binding]; other site 1155766003868 phosphorylation site [posttranslational modification] 1155766003869 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1155766003870 ATP binding site [chemical binding]; other site 1155766003871 Mg2+ binding site [ion binding]; other site 1155766003872 G-X-G motif; other site 1155766003873 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1155766003874 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1155766003875 active site 1155766003876 phosphorylation site [posttranslational modification] 1155766003877 intermolecular recognition site; other site 1155766003878 dimerization interface [polypeptide binding]; other site 1155766003879 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1155766003880 DNA binding site [nucleotide binding] 1155766003881 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1155766003882 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 1155766003883 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 1155766003884 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 1155766003885 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 1155766003886 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1155766003887 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1155766003888 The substrate binding domain of LysR-type transcriptional regulator MleR which required for malolactic fermentation, contains type 2 periplasmic binidning fold; Region: PBP2_MleR; cd08437 1155766003889 putative dimerization interface [polypeptide binding]; other site 1155766003890 pyruvate kinase; Provisional; Region: PRK06354 1155766003891 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1155766003892 domain interfaces; other site 1155766003893 active site 1155766003894 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl17700 1155766003895 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 1155766003896 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 1155766003897 active site 1155766003898 ADP/pyrophosphate binding site [chemical binding]; other site 1155766003899 dimerization interface [polypeptide binding]; other site 1155766003900 allosteric effector site; other site 1155766003901 fructose-1,6-bisphosphate binding site; other site 1155766003902 DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587 1155766003903 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 1155766003904 active site 1155766003905 PHP Thumb interface [polypeptide binding]; other site 1155766003906 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1155766003907 generic binding surface I; other site 1155766003908 generic binding surface II; other site 1155766003909 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 1155766003910 drug efflux system protein MdtG; Provisional; Region: PRK09874 1155766003911 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1155766003912 putative substrate translocation pore; other site 1155766003913 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1155766003914 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1155766003915 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1155766003916 active site 1155766003917 motif I; other site 1155766003918 motif II; other site 1155766003919 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1155766003920 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 1155766003921 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1155766003922 Homeodomain-like domain; Region: HTH_23; pfam13384 1155766003923 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1155766003924 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1155766003925 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1155766003926 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1155766003927 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1155766003928 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1155766003929 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1155766003930 putative active site [active] 1155766003931 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 1155766003932 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 1155766003933 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1155766003934 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1155766003935 active site 1155766003936 dimer interface [polypeptide binding]; other site 1155766003937 motif 1; other site 1155766003938 motif 2; other site 1155766003939 motif 3; other site 1155766003940 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1155766003941 anticodon binding site; other site 1155766003942 4-oxalocrotonate tautomerase; Provisional; Region: PRK02220 1155766003943 active site 1 [active] 1155766003944 dimer interface [polypeptide binding]; other site 1155766003945 hexamer interface [polypeptide binding]; other site 1155766003946 active site 2 [active] 1155766003947 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 1155766003948 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1155766003949 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 1155766003950 Part of AAA domain; Region: AAA_19; pfam13245 1155766003951 Family description; Region: UvrD_C_2; pfam13538 1155766003952 hypothetical protein; Provisional; Region: PRK12378 1155766003953 hypothetical protein; Provisional; Region: PRK13670 1155766003954 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673 1155766003955 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1155766003956 S-adenosylmethionine binding site [chemical binding]; other site 1155766003957 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 1155766003958 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1155766003959 Zn2+ binding site [ion binding]; other site 1155766003960 Mg2+ binding site [ion binding]; other site 1155766003961 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 1155766003962 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1155766003963 active site 1155766003964 (T/H)XGH motif; other site 1155766003965 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 1155766003966 GTPase YqeH; Provisional; Region: PRK13796 1155766003967 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 1155766003968 GTP/Mg2+ binding site [chemical binding]; other site 1155766003969 G4 box; other site 1155766003970 G5 box; other site 1155766003971 G1 box; other site 1155766003972 Switch I region; other site 1155766003973 G2 box; other site 1155766003974 G3 box; other site 1155766003975 Switch II region; other site 1155766003976 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 1155766003977 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1155766003978 active site 1155766003979 motif I; other site 1155766003980 motif II; other site 1155766003981 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1155766003982 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 1155766003983 Uncharacterized protein family UPF0547; Region: UPF0547; pfam10571 1155766003984 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1155766003985 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1155766003986 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1155766003987 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1155766003988 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1155766003989 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 1155766003990 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 1155766003991 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1155766003992 carboxyltransferase (CT) interaction site; other site 1155766003993 biotinylation site [posttranslational modification]; other site 1155766003994 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 1155766003995 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1155766003996 dimer interface [polypeptide binding]; other site 1155766003997 active site 1155766003998 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1155766003999 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1155766004000 NAD(P) binding site [chemical binding]; other site 1155766004001 active site 1155766004002 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1155766004003 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1155766004004 acyl carrier protein; Provisional; Region: acpP; PRK00982 1155766004005 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 1155766004006 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1155766004007 dimer interface [polypeptide binding]; other site 1155766004008 active site 1155766004009 CoA binding pocket [chemical binding]; other site 1155766004010 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1155766004011 MarR family; Region: MarR_2; pfam12802 1155766004012 Nuclease subunit of the excinuclease complex [DNA replication, recombination, and repair]; Region: UvrC; COG0322 1155766004013 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1155766004014 GIY-YIG motif/motif A; other site 1155766004015 active site 1155766004016 catalytic site [active] 1155766004017 putative DNA binding site [nucleotide binding]; other site 1155766004018 metal binding site [ion binding]; metal-binding site 1155766004019 Protein of unknown function (DUF1797); Region: DUF1797; pfam08796 1155766004020 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1155766004021 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1155766004022 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1155766004023 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 1155766004024 putative ADP-binding pocket [chemical binding]; other site 1155766004025 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1155766004026 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1155766004027 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 1155766004028 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1155766004029 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1155766004030 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1155766004031 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1155766004032 dimerization domain swap beta strand [polypeptide binding]; other site 1155766004033 regulatory protein interface [polypeptide binding]; other site 1155766004034 active site 1155766004035 regulatory phosphorylation site [posttranslational modification]; other site 1155766004036 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1155766004037 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1155766004038 Walker A motif; other site 1155766004039 ATP binding site [chemical binding]; other site 1155766004040 Walker B motif; other site 1155766004041 arginine finger; other site 1155766004042 UvrB/uvrC motif; Region: UVR; pfam02151 1155766004043 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1155766004044 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1155766004045 Walker A motif; other site 1155766004046 ATP binding site [chemical binding]; other site 1155766004047 Walker B motif; other site 1155766004048 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1155766004049 Domain of unknown function (DUF1827); Region: DUF1827; pfam08860 1155766004050 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 1155766004051 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 1155766004052 G1 box; other site 1155766004053 putative GEF interaction site [polypeptide binding]; other site 1155766004054 GTP/Mg2+ binding site [chemical binding]; other site 1155766004055 Switch I region; other site 1155766004056 G2 box; other site 1155766004057 G3 box; other site 1155766004058 Switch II region; other site 1155766004059 G4 box; other site 1155766004060 G5 box; other site 1155766004061 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 1155766004062 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1155766004063 Domain of unknown function DUF21; Region: DUF21; pfam01595 1155766004064 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1155766004065 Transporter associated domain; Region: CorC_HlyC; pfam03471 1155766004066 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1155766004067 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1155766004068 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444 1155766004069 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1155766004070 Coenzyme A binding pocket [chemical binding]; other site 1155766004071 hypothetical protein; Provisional; Region: PRK13662 1155766004072 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 1155766004073 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1155766004074 minor groove reading motif; other site 1155766004075 helix-hairpin-helix signature motif; other site 1155766004076 substrate binding pocket [chemical binding]; other site 1155766004077 active site 1155766004078 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 1155766004079 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 1155766004080 DNA binding and oxoG recognition site [nucleotide binding] 1155766004081 recombination regulator RecX; Provisional; Region: recX; PRK14135 1155766004082 TRAM domain; Region: TRAM; pfam01938 1155766004083 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 1155766004084 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1155766004085 S-adenosylmethionine binding site [chemical binding]; other site 1155766004086 Chitin binding domain; Region: Chitin_bind_3; pfam03067 1155766004087 TspO/MBR family; Region: TspO_MBR; pfam03073 1155766004088 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 1155766004089 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1155766004090 DNA-binding site [nucleotide binding]; DNA binding site 1155766004091 RNA-binding motif; other site 1155766004092 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 1155766004093 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1155766004094 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1155766004095 Predicted membrane protein [Function unknown]; Region: COG2246 1155766004096 GtrA-like protein; Region: GtrA; pfam04138 1155766004097 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 1155766004098 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1155766004099 Protein of unknown function (DUF1189); Region: DUF1189; pfam06691 1155766004100 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1155766004101 Phosphoglycerate Dehydrogenase, 2-hydroxyacid dehydrogenase family; Region: PGDH_1; cd12155 1155766004102 putative ligand binding site [chemical binding]; other site 1155766004103 NAD binding site [chemical binding]; other site 1155766004104 catalytic site [active] 1155766004105 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 1155766004106 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1155766004107 TrkA-N domain; Region: TrkA_N; pfam02254 1155766004108 TrkA-C domain; Region: TrkA_C; pfam02080 1155766004109 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1155766004110 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1155766004111 active site 1155766004112 phosphorylation site [posttranslational modification] 1155766004113 intermolecular recognition site; other site 1155766004114 dimerization interface [polypeptide binding]; other site 1155766004115 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1155766004116 DNA binding residues [nucleotide binding] 1155766004117 dimerization interface [polypeptide binding]; other site 1155766004118 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1155766004119 Histidine kinase; Region: HisKA_3; pfam07730 1155766004120 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1155766004121 ATP binding site [chemical binding]; other site 1155766004122 Mg2+ binding site [ion binding]; other site 1155766004123 G-X-G motif; other site 1155766004124 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 1155766004125 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1155766004126 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1155766004127 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1155766004128 YceG-like family; Region: YceG; pfam02618 1155766004129 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 1155766004130 dimerization interface [polypeptide binding]; other site 1155766004131 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1155766004132 Beta-lactamase; Region: Beta-lactamase; pfam00144 1155766004133 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1155766004134 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1155766004135 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1155766004136 Helix-turn-helix domain; Region: HTH_38; pfam13936 1155766004137 Integrase core domain; Region: rve; pfam00665 1155766004138 Integrase core domain; Region: rve_3; cl15866 1155766004139 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 1155766004140 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1155766004141 Homeodomain-like domain; Region: HTH_23; pfam13384 1155766004142 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1155766004143 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1155766004144 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1155766004145 NAD(P) binding site [chemical binding]; other site 1155766004146 active site 1155766004147 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 1155766004148 ligand binding site; other site 1155766004149 tetramer interface; other site 1155766004150 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1155766004151 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1155766004152 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1155766004153 aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181 1155766004154 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1155766004155 inhibitor-cofactor binding pocket; inhibition site 1155766004156 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1155766004157 catalytic residue [active] 1155766004158 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 1155766004159 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 1155766004160 putative trimer interface [polypeptide binding]; other site 1155766004161 putative CoA binding site [chemical binding]; other site 1155766004162 UDP-N-acetyl-D-glucosamine 2-epimerase, UDP-hydrolysing; Region: NeuC_NnaA; TIGR03568 1155766004163 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 1155766004164 active site 1155766004165 homodimer interface [polypeptide binding]; other site 1155766004166 N-acetylneuraminate synthase; Region: NeuB_NnaB; TIGR03569 1155766004167 NeuB family; Region: NeuB; pfam03102 1155766004168 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 1155766004169 NeuB binding interface [polypeptide binding]; other site 1155766004170 putative substrate binding site [chemical binding]; other site 1155766004171 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 1155766004172 Polysaccharide biosynthesis protein; Region: Polysacc_synt_2; pfam02719 1155766004173 NAD(P) binding site [chemical binding]; other site 1155766004174 homodimer interface [polypeptide binding]; other site 1155766004175 substrate binding site [chemical binding]; other site 1155766004176 active site 1155766004177 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1155766004178 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 1155766004179 O-Antigen ligase; Region: Wzy_C; pfam04932 1155766004180 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 1155766004181 Core-2/I-Branching enzyme; Region: Branch; pfam02485 1155766004182 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1155766004183 This family is most closely related to the GT1 family of glycosyltransferases. capH in Staphylococcus aureus has been shown to be required for the biosynthesis of the type 1 capsular polysaccharide (CP1); Region: GT1_CapH_like; cd03812 1155766004184 putative ADP-binding pocket [chemical binding]; other site 1155766004185 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1155766004186 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1155766004187 active site 1155766004188 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1155766004189 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 1155766004190 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1155766004191 Beta-lactamase; Region: Beta-lactamase; pfam00144 1155766004192 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1155766004193 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1155766004194 Myxococcus xanthus RfbC like proteins are required for O-antigen biosynthesis; Region: GT2_RfbC_Mx_like; cd04184 1155766004195 Probable Catalytic site; other site 1155766004196 metal-binding site 1155766004197 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1155766004198 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 1155766004199 Probable Catalytic site; other site 1155766004200 metal-binding site 1155766004201 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1155766004202 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1155766004203 S-adenosylmethionine binding site [chemical binding]; other site 1155766004204 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 1155766004205 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 1155766004206 Walker A/P-loop; other site 1155766004207 ATP binding site [chemical binding]; other site 1155766004208 Q-loop/lid; other site 1155766004209 ABC transporter signature motif; other site 1155766004210 Walker B; other site 1155766004211 D-loop; other site 1155766004212 H-loop/switch region; other site 1155766004213 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 1155766004214 putative carbohydrate binding site [chemical binding]; other site 1155766004215 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 1155766004216 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1155766004217 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 1155766004218 MULE transposase domain; Region: MULE; pfam10551 1155766004219 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 1155766004220 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 1155766004221 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 1155766004222 NADP binding site [chemical binding]; other site 1155766004223 active site 1155766004224 putative substrate binding site [chemical binding]; other site 1155766004225 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 1155766004226 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 1155766004227 NAD binding site [chemical binding]; other site 1155766004228 substrate binding site [chemical binding]; other site 1155766004229 homodimer interface [polypeptide binding]; other site 1155766004230 active site 1155766004231 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 1155766004232 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 1155766004233 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 1155766004234 substrate binding site; other site 1155766004235 tetramer interface; other site 1155766004236 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1155766004237 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196 1155766004238 Probable Catalytic site; other site 1155766004239 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1155766004240 active site 1155766004241 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1155766004242 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 1155766004243 Probable Catalytic site; other site 1155766004244 metal-binding site 1155766004245 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 1155766004246 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 1155766004247 Mg++ binding site [ion binding]; other site 1155766004248 putative catalytic motif [active] 1155766004249 substrate binding site [chemical binding]; other site 1155766004250 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 1155766004251 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1155766004252 active site 1155766004253 flavodoxin; Validated; Region: PRK07308 1155766004254 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1155766004255 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1155766004256 WHG domain; Region: WHG; pfam13305 1155766004257 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 1155766004258 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 1155766004259 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 1155766004260 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1155766004261 Homeodomain-like domain; Region: HTH_23; pfam13384 1155766004262 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1155766004263 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1155766004264 Helix-turn-helix domain; Region: HTH_28; pfam13518 1155766004265 Helix-turn-helix domain; Region: HTH_28; pfam13518 1155766004266 Winged helix-turn helix; Region: HTH_29; pfam13551 1155766004267 Homeodomain-like domain; Region: HTH_32; pfam13565 1155766004268 putative transposase OrfB; Reviewed; Region: PHA02517 1155766004269 Integrase core domain; Region: rve; pfam00665 1155766004270 Integrase core domain; Region: rve_3; pfam13683 1155766004271 Transposase; Region: HTH_Tnp_1; pfam01527 1155766004272 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1155766004273 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1155766004274 amidase catalytic site [active] 1155766004275 Zn binding residues [ion binding]; other site 1155766004276 substrate binding site [chemical binding]; other site 1155766004277 Phage uncharacterized protein (Phage_XkdX); Region: Phage_XkdX; pfam09693 1155766004278 Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; Region: SPEC; cl02488 1155766004279 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 1155766004280 Phage-related protein [Function unknown]; Region: COG4722 1155766004281 Phage tail protein; Region: Sipho_tail; cl17486 1155766004282 Phage-related minor tail protein [Function unknown]; Region: COG5280 1155766004283 membrane protein P6; Region: PHA01399 1155766004284 membrane protein P6; Region: PHA01399 1155766004285 Phage capsid family; Region: Phage_capsid; pfam05065 1155766004286 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 1155766004287 oligomer interface [polypeptide binding]; other site 1155766004288 active site residues [active] 1155766004289 Phage portal protein; Region: Phage_portal; pfam04860 1155766004290 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 1155766004291 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1155766004292 active site 1155766004293 AAA ATPase containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: MDN1; COG5271 1155766004294 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 1155766004295 Protein of unknown function (DUF1642); Region: DUF1642; pfam07852 1155766004296 YopX protein; Region: YopX; pfam09643 1155766004297 Protein of unknown function (DUF1140); Region: DUF1140; pfam06600 1155766004298 Helix-turn-helix domain; Region: HTH_36; pfam13730 1155766004299 Protein of unknown function (DUF968); Region: DUF968; pfam06147 1155766004300 Protein of unknown function (DUF1071); Region: DUF1071; pfam06378 1155766004301 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 1155766004302 ORF6C domain; Region: ORF6C; pfam10552 1155766004303 Domain of unknown function (DUF771); Region: DUF771; pfam05595 1155766004304 non-specific DNA binding site [nucleotide binding]; other site 1155766004305 salt bridge; other site 1155766004306 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 1155766004307 sequence-specific DNA binding site [nucleotide binding]; other site 1155766004308 Prophage antirepressor [Transcription]; Region: COG3617 1155766004309 BRO family, N-terminal domain; Region: Bro-N; smart01040 1155766004310 Phage antirepressor protein KilAC domain; Region: ANT; pfam03374 1155766004311 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1155766004312 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1155766004313 non-specific DNA binding site [nucleotide binding]; other site 1155766004314 salt bridge; other site 1155766004315 sequence-specific DNA binding site [nucleotide binding]; other site 1155766004316 Domain of unknown function (DUF955); Region: DUF955; pfam06114 1155766004317 Domain of unknown function (DUF1934); Region: DUF1934; cl01870 1155766004318 Short C-terminal domain; Region: SHOCT; pfam09851 1155766004319 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 1155766004320 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 1155766004321 Int/Topo IB signature motif; other site 1155766004322 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 1155766004323 Protein of unknown function (DUF3036); Region: DUF3036; pfam11234 1155766004324 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1155766004325 sequence-specific DNA binding site [nucleotide binding]; other site 1155766004326 salt bridge; other site 1155766004327 Predicted membrane protein [Function unknown]; Region: COG2261 1155766004328 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 1155766004329 Small integral membrane protein (DUF2273); Region: DUF2273; pfam10031 1155766004330 oxidoreductase; Provisional; Region: PRK07985 1155766004331 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1155766004332 NAD(P) binding site [chemical binding]; other site 1155766004333 active site 1155766004334 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 1155766004335 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 1155766004336 Cl binding site [ion binding]; other site 1155766004337 oligomer interface [polypeptide binding]; other site 1155766004338 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 1155766004339 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 1155766004340 Ligand binding site; other site 1155766004341 metal-binding site 1155766004342 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 1155766004343 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 1155766004344 Ligand binding site; other site 1155766004345 metal-binding site 1155766004346 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1155766004347 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1155766004348 active site 1155766004349 motif I; other site 1155766004350 motif II; other site 1155766004351 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1155766004352 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1155766004353 catalytic triad [active] 1155766004354 conserved cis-peptide bond; other site 1155766004355 conserved hypothetical protein; Region: TIGR02328 1155766004356 Pyrimidine dimer DNA glycosylase; Region: Pyr_excise; pfam03013 1155766004357 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1155766004358 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1155766004359 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1155766004360 DNA-binding site [nucleotide binding]; DNA binding site 1155766004361 RNA-binding motif; other site 1155766004362 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 1155766004363 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1155766004364 motif II; other site 1155766004365 mannonate dehydratase; Provisional; Region: PRK03906 1155766004366 mannonate dehydratase; Region: uxuA; TIGR00695 1155766004367 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 1155766004368 active pocket/dimerization site; other site 1155766004369 active site 1155766004370 phosphorylation site [posttranslational modification] 1155766004371 PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830 1155766004372 active site 1155766004373 phosphorylation site [posttranslational modification] 1155766004374 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 1155766004375 PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609 1155766004376 potential frameshift: common BLAST hit: gi|150017063|ref|YP_001309317.1| iron-containing alcohol dehydrogenase 1155766004377 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 1155766004378 active site 1155766004379 NAD binding site [chemical binding]; other site 1155766004380 metal binding site [ion binding]; metal-binding site 1155766004381 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 1155766004382 Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_12; cd12177 1155766004383 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1155766004384 putative ligand binding site [chemical binding]; other site 1155766004385 putative NAD binding site [chemical binding]; other site 1155766004386 catalytic site [active] 1155766004387 Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023 1155766004388 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1155766004389 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1155766004390 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1155766004391 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1155766004392 putative active site [active] 1155766004393 Protein of unknown function (DUF3955); Region: DUF3955; pfam13127 1155766004394 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 1155766004395 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1155766004396 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1155766004397 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1155766004398 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 1155766004399 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 1155766004400 Isochorismatase family; Region: Isochorismatase; pfam00857 1155766004401 catalytic triad [active] 1155766004402 conserved cis-peptide bond; other site 1155766004403 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 1155766004404 ArsC family; Region: ArsC; pfam03960 1155766004405 putative catalytic residues [active] 1155766004406 thiol/disulfide switch; other site 1155766004407 Mga helix-turn-helix domain; Region: Mga; pfam05043 1155766004408 CAAX protease self-immunity; Region: Abi; pfam02517 1155766004409 foldase protein PrsA; Reviewed; Region: prsA; PRK01326 1155766004410 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 1155766004411 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 1155766004412 active site 1155766004413 intersubunit interactions; other site 1155766004414 catalytic residue [active] 1155766004415 PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; pfam03829 1155766004416 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1155766004417 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1155766004418 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1155766004419 PTS system, glucitol/sorbitol-specific, IIBC component; Region: EIIBC-GUT; TIGR00825 1155766004420 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 1155766004421 Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663 1155766004422 PTS system enzyme II sorbitol-specific factor; Region: EII-GUT; pfam03608 1155766004423 Glucitol operon activator protein (GutM); Region: GutM; pfam06923 1155766004424 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1155766004425 HTH domain; Region: HTH_11; pfam08279 1155766004426 PRD domain; Region: PRD; pfam00874 1155766004427 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1155766004428 active site 1155766004429 P-loop; other site 1155766004430 phosphorylation site [posttranslational modification] 1155766004431 Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2; Region: PTS_EIIA_2; pfam00359 1155766004432 active site 1155766004433 phosphorylation site [posttranslational modification] 1155766004434 sorbitol-6-phosphate 2-dehydrogenase; Provisional; Region: PRK06171 1155766004435 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1155766004436 NAD(P) binding site [chemical binding]; other site 1155766004437 active site 1155766004438 Domain of unknown function (DUF378); Region: DUF378; pfam04070 1155766004439 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1155766004440 Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471 1155766004441 putative dimer interface [polypeptide binding]; other site 1155766004442 potential frameshift: common BLAST hit: gi|29377271|ref|NP_816425.1| ISEf1, transposase 1155766004443 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1155766004444 potential frameshift: common BLAST hit: gi|29377271|ref|NP_816425.1| ISEf1, transposase 1155766004445 MULE transposase domain; Region: MULE; pfam10551 1155766004446 MULE transposase domain; Region: MULE; pfam10551 1155766004447 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1155766004448 Helix-turn-helix domain; Region: HTH_38; pfam13936 1155766004449 Integrase core domain; Region: rve; pfam00665 1155766004450 Integrase core domain; Region: rve_3; cl15866 1155766004451 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 1155766004452 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 1155766004453 Int/Topo IB signature motif; other site 1155766004454 GTP-binding protein LepA; Provisional; Region: PRK05433 1155766004455 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1155766004456 G1 box; other site 1155766004457 putative GEF interaction site [polypeptide binding]; other site 1155766004458 GTP/Mg2+ binding site [chemical binding]; other site 1155766004459 Switch I region; other site 1155766004460 G2 box; other site 1155766004461 G3 box; other site 1155766004462 Switch II region; other site 1155766004463 G4 box; other site 1155766004464 G5 box; other site 1155766004465 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 1155766004466 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1155766004467 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1155766004468 Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527 1155766004469 Sterol carrier protein domain; Region: SCP2_2; pfam13530 1155766004470 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014 1155766004471 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 1155766004472 Clp amino terminal domain; Region: Clp_N; pfam02861 1155766004473 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1155766004474 Walker A motif; other site 1155766004475 ATP binding site [chemical binding]; other site 1155766004476 Walker B motif; other site 1155766004477 arginine finger; other site 1155766004478 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1155766004479 Walker A motif; other site 1155766004480 ATP binding site [chemical binding]; other site 1155766004481 Walker B motif; other site 1155766004482 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1155766004483 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 1155766004484 Protein of unknown function (DUF1294); Region: DUF1294; pfam06961 1155766004485 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 1155766004486 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1155766004487 peptidase T; Region: peptidase-T; TIGR01882 1155766004488 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 1155766004489 metal binding site [ion binding]; metal-binding site 1155766004490 dimer interface [polypeptide binding]; other site 1155766004491 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1155766004492 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1155766004493 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 1155766004494 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1155766004495 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1155766004496 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 1155766004497 Family of unknown function (DUF633); Region: DUF633; pfam04816 1155766004498 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1155766004499 primosomal protein DnaI; Reviewed; Region: PRK08939 1155766004500 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 1155766004501 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1155766004502 Walker A motif; other site 1155766004503 ATP binding site [chemical binding]; other site 1155766004504 Walker B motif; other site 1155766004505 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 1155766004506 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 1155766004507 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 1155766004508 ATP cone domain; Region: ATP-cone; pfam03477 1155766004509 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 1155766004510 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1155766004511 CoA-binding site [chemical binding]; other site 1155766004512 ATP-binding [chemical binding]; other site 1155766004513 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 1155766004514 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 1155766004515 DNA binding site [nucleotide binding] 1155766004516 catalytic residue [active] 1155766004517 H2TH interface [polypeptide binding]; other site 1155766004518 putative catalytic residues [active] 1155766004519 turnover-facilitating residue; other site 1155766004520 intercalation triad [nucleotide binding]; other site 1155766004521 8OG recognition residue [nucleotide binding]; other site 1155766004522 putative reading head residues; other site 1155766004523 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1155766004524 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1155766004525 DNA polymerase I; Provisional; Region: PRK05755 1155766004526 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1155766004527 active site 1155766004528 metal binding site 1 [ion binding]; metal-binding site 1155766004529 putative 5' ssDNA interaction site; other site 1155766004530 metal binding site 3; metal-binding site 1155766004531 metal binding site 2 [ion binding]; metal-binding site 1155766004532 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1155766004533 putative DNA binding site [nucleotide binding]; other site 1155766004534 putative metal binding site [ion binding]; other site 1155766004535 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 1155766004536 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1155766004537 active site 1155766004538 DNA binding site [nucleotide binding] 1155766004539 catalytic site [active] 1155766004540 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 1155766004541 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 1155766004542 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1155766004543 active site 2 [active] 1155766004544 active site 1 [active] 1155766004545 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1155766004546 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1155766004547 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1155766004548 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1155766004549 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1155766004550 putative active site [active] 1155766004551 hypothetical protein; Provisional; Region: PRK04351 1155766004552 SprT homologues; Region: SprT; cl01182 1155766004553 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 1155766004554 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 1155766004555 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 1155766004556 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 1155766004557 RNA binding site [nucleotide binding]; other site 1155766004558 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1155766004559 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 1155766004560 active site 1155766004561 metal binding site [ion binding]; metal-binding site 1155766004562 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 1155766004563 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 1155766004564 active site residue [active] 1155766004565 Protein of unknown function (DUF3650); Region: DUF3650; pfam12368 1155766004566 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1155766004567 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1155766004568 active site 1155766004569 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 1155766004570 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1155766004571 Protein of unknown function (DUF1149); Region: DUF1149; cl11551 1155766004572 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1155766004573 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1155766004574 motif II; other site 1155766004575 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1155766004576 catalytic core [active] 1155766004577 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1155766004578 Transcription elongation factor Elf1 like; Region: Elf1; cl02038 1155766004579 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1155766004580 Protein of unknown function (DUF1538); Region: DUF1538; pfam07556 1155766004581 Protein of unknown function (DUF1538); Region: DUF1538; pfam07556 1155766004582 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1155766004583 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1155766004584 dimer interface [polypeptide binding]; other site 1155766004585 conserved gate region; other site 1155766004586 putative PBP binding loops; other site 1155766004587 ABC-ATPase subunit interface; other site 1155766004588 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1155766004589 dimer interface [polypeptide binding]; other site 1155766004590 conserved gate region; other site 1155766004591 putative PBP binding loops; other site 1155766004592 ABC-ATPase subunit interface; other site 1155766004593 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1155766004594 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1155766004595 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1155766004596 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1155766004597 active site 1155766004598 phosphorylation site [posttranslational modification] 1155766004599 intermolecular recognition site; other site 1155766004600 dimerization interface [polypeptide binding]; other site 1155766004601 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1155766004602 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1155766004603 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1155766004604 Histidine kinase; Region: His_kinase; pfam06580 1155766004605 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1155766004606 ATP binding site [chemical binding]; other site 1155766004607 Mg2+ binding site [ion binding]; other site 1155766004608 G-X-G motif; other site 1155766004609 prephenate dehydratase; Provisional; Region: PRK11898 1155766004610 Prephenate dehydratase; Region: PDT; pfam00800 1155766004611 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 1155766004612 putative L-Phe binding site [chemical binding]; other site 1155766004613 shikimate kinase; Reviewed; Region: aroK; PRK00131 1155766004614 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1155766004615 ADP binding site [chemical binding]; other site 1155766004616 magnesium binding site [ion binding]; other site 1155766004617 putative shikimate binding site; other site 1155766004618 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 1155766004619 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 1155766004620 hinge; other site 1155766004621 active site 1155766004622 prephenate dehydrogenase; Validated; Region: PRK06545 1155766004623 prephenate dehydrogenase; Validated; Region: PRK08507 1155766004624 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 1155766004625 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 1155766004626 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 1155766004627 Tetramer interface [polypeptide binding]; other site 1155766004628 active site 1155766004629 FMN-binding site [chemical binding]; other site 1155766004630 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 1155766004631 active site 1155766004632 dimer interface [polypeptide binding]; other site 1155766004633 metal binding site [ion binding]; metal-binding site 1155766004634 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 1155766004635 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 1155766004636 Beta galactosidase small chain; Region: Bgal_small_N; pfam02929 1155766004637 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 1155766004638 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 1155766004639 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 1155766004640 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 1155766004641 Melibiase; Region: Melibiase; pfam02065 1155766004642 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1155766004643 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1155766004644 DNA binding site [nucleotide binding] 1155766004645 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1155766004646 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 1155766004647 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1155766004648 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 1155766004649 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1155766004650 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 1155766004651 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 1155766004652 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1155766004653 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 1155766004654 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 1155766004655 Ribosomal RNA adenine dimethylase; Region: RrnaAD; pfam00398 1155766004656 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1155766004657 S-adenosylmethionine binding site [chemical binding]; other site 1155766004658 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 1155766004659 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 1155766004660 trimer interface [polypeptide binding]; other site 1155766004661 active site 1155766004662 substrate binding site [chemical binding]; other site 1155766004663 CoA binding site [chemical binding]; other site 1155766004664 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 1155766004665 active site 1155766004666 NTP binding site [chemical binding]; other site 1155766004667 metal binding triad [ion binding]; metal-binding site 1155766004668 antibiotic binding site [chemical binding]; other site 1155766004669 H+ Antiporter protein; Region: 2A0121; TIGR00900 1155766004670 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1155766004671 putative substrate translocation pore; other site 1155766004672 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1155766004673 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 1155766004674 catalytic residues [active] 1155766004675 catalytic nucleophile [active] 1155766004676 Recombinase; Region: Recombinase; pfam07508 1155766004677 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 1155766004678 Recombinase; Region: Recombinase; pfam07508 1155766004679 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1155766004680 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 1155766004681 catalytic residues [active] 1155766004682 catalytic nucleophile [active] 1155766004683 Recombinase; Region: Recombinase; pfam07508 1155766004684 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 1155766004685 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1155766004686 amidase catalytic site [active] 1155766004687 Zn binding residues [ion binding]; other site 1155766004688 substrate binding site [chemical binding]; other site 1155766004689 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 1155766004690 Bacterial SH3 domain; Region: SH3_3; cl17532 1155766004691 Holin family; Region: Phage_holin_4; pfam05105 1155766004692 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 1155766004693 active site 1155766004694 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 1155766004695 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 1155766004696 Phage tail protein; Region: Sipho_tail; pfam05709 1155766004697 Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; Region: SPEC; cl02488 1155766004698 linker region; other site 1155766004699 membrane protein P6; Region: PHA01399 1155766004700 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 1155766004701 Bacteriophage protein of unknown function (DUF646); Region: DUF646; pfam04883 1155766004702 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 1155766004703 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 1155766004704 oligomerization interface [polypeptide binding]; other site 1155766004705 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 1155766004706 Phage capsid family; Region: Phage_capsid; pfam05065 1155766004707 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 1155766004708 oligomer interface [polypeptide binding]; other site 1155766004709 active site residues [active] 1155766004710 Phage-related protein [Function unknown]; Region: COG4695 1155766004711 Phage portal protein; Region: Phage_portal; pfam04860 1155766004712 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 1155766004713 AAA domain; Region: AAA_17; pfam13207 1155766004714 AAA domain; Region: AAA_18; pfam13238 1155766004715 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1155766004716 putative active site pocket [active] 1155766004717 dimerization interface [polypeptide binding]; other site 1155766004718 putative catalytic residue [active] 1155766004719 Putative amidoligase enzyme; Region: Amidoligase_2; pfam12224 1155766004720 Protein of unknown function (DUF3782); Region: DUF3782; pfam12644 1155766004721 Domain of unknown function (DUF4314); Region: DUF4314; pfam14192 1155766004722 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1155766004723 cofactor binding site; other site 1155766004724 DNA binding site [nucleotide binding] 1155766004725 substrate interaction site [chemical binding]; other site 1155766004726 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1155766004727 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 1155766004728 ParB-like nuclease domain; Region: ParBc; pfam02195 1155766004729 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 1155766004730 DNA methylase; Region: N6_N4_Mtase; pfam01555 1155766004731 S-adenosylmethionine synthetase; Provisional; Region: PRK12459 1155766004732 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1155766004733 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 1155766004734 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1155766004735 ATP binding site [chemical binding]; other site 1155766004736 putative Mg++ binding site [ion binding]; other site 1155766004737 VRR-NUC domain; Region: VRR_NUC; pfam08774 1155766004738 Primase C terminal 1 (PriCT-1); Region: PriCT_1; smart00942 1155766004739 D5 N terminal like; Region: D5_N; pfam08706 1155766004740 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 1155766004741 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1155766004742 non-specific DNA binding site [nucleotide binding]; other site 1155766004743 salt bridge; other site 1155766004744 sequence-specific DNA binding site [nucleotide binding]; other site 1155766004745 Protein of unknown function (DUF2800); Region: DUF2800; pfam10926 1155766004746 Protein of unknown function (DUF2815); Region: DUF2815; pfam10991 1155766004747 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_A; cd08642 1155766004748 active site 1155766004749 DNA binding site [nucleotide binding] 1155766004750 catalytic site [active] 1155766004751 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1155766004752 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 1155766004753 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 1155766004754 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_23; cd09011 1155766004755 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1155766004756 Protein of unknown function (DUF3788); Region: DUF3788; pfam12663 1155766004757 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1155766004758 non-specific DNA binding site [nucleotide binding]; other site 1155766004759 salt bridge; other site 1155766004760 sequence-specific DNA binding site [nucleotide binding]; other site 1155766004761 Catalytic GIY-YIG domain of type II restriction enzyme R.Cfr42I and similar proteins; Region: GIY-YIG_RE_Cfr42I; cd10453 1155766004762 GIY-YIG motif/motif A; other site 1155766004763 putative active site [active] 1155766004764 putative metal binding site [ion binding]; other site 1155766004765 C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145 1155766004766 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1155766004767 cofactor binding site; other site 1155766004768 DNA binding site [nucleotide binding] 1155766004769 substrate interaction site [chemical binding]; other site 1155766004770 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1155766004771 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 1155766004772 non-specific DNA binding site [nucleotide binding]; other site 1155766004773 salt bridge; other site 1155766004774 sequence-specific DNA binding site [nucleotide binding]; other site 1155766004775 TRAM domain; Region: TRAM; cl01282 1155766004776 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 1155766004777 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1155766004778 S-adenosylmethionine binding site [chemical binding]; other site 1155766004779 putative lipid kinase; Reviewed; Region: PRK13055 1155766004780 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1155766004781 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 1155766004782 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 1155766004783 GatB domain; Region: GatB_Yqey; smart00845 1155766004784 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1155766004785 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 1155766004786 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 1155766004787 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 1155766004788 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1155766004789 nucleotide binding pocket [chemical binding]; other site 1155766004790 K-X-D-G motif; other site 1155766004791 catalytic site [active] 1155766004792 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1155766004793 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 1155766004794 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1155766004795 Dimer interface [polypeptide binding]; other site 1155766004796 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 1155766004797 Part of AAA domain; Region: AAA_19; pfam13245 1155766004798 Family description; Region: UvrD_C_2; pfam13538 1155766004799 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 1155766004800 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 1155766004801 Cl- selectivity filter; other site 1155766004802 Cl- binding residues [ion binding]; other site 1155766004803 pore gating glutamate residue; other site 1155766004804 dimer interface [polypeptide binding]; other site 1155766004805 H+/Cl- coupling transport residue; other site 1155766004806 TrkA-C domain; Region: TrkA_C; pfam02080 1155766004807 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 1155766004808 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1155766004809 active site 1155766004810 phosphorylation site [posttranslational modification] 1155766004811 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1155766004812 active site 1155766004813 P-loop; other site 1155766004814 phosphorylation site [posttranslational modification] 1155766004815 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 1155766004816 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 1155766004817 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1155766004818 putative substrate binding site [chemical binding]; other site 1155766004819 putative ATP binding site [chemical binding]; other site 1155766004820 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1155766004821 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1155766004822 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1155766004823 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 1155766004824 G1 box; other site 1155766004825 GTP/Mg2+ binding site [chemical binding]; other site 1155766004826 Switch I region; other site 1155766004827 G2 box; other site 1155766004828 G3 box; other site 1155766004829 Switch II region; other site 1155766004830 G4 box; other site 1155766004831 G5 box; other site 1155766004832 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1155766004833 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 1155766004834 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1155766004835 Walker A motif; other site 1155766004836 ATP binding site [chemical binding]; other site 1155766004837 Walker B motif; other site 1155766004838 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1155766004839 trigger factor; Provisional; Region: tig; PRK01490 1155766004840 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1155766004841 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1155766004842 RDD family; Region: RDD; pfam06271 1155766004843 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 1155766004844 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 1155766004845 tandem repeat interface [polypeptide binding]; other site 1155766004846 oligomer interface [polypeptide binding]; other site 1155766004847 active site residues [active] 1155766004848 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1155766004849 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1155766004850 glutaminase active site [active] 1155766004851 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1155766004852 dimer interface [polypeptide binding]; other site 1155766004853 active site 1155766004854 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1155766004855 dimer interface [polypeptide binding]; other site 1155766004856 active site 1155766004857 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 1155766004858 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 1155766004859 active site 1155766004860 substrate binding site [chemical binding]; other site 1155766004861 metal binding site [ion binding]; metal-binding site 1155766004862 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 1155766004863 YbbR-like protein; Region: YbbR; pfam07949 1155766004864 Uncharacterized conserved protein [Function unknown]; Region: COG1624 1155766004865 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 1155766004866 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 1155766004867 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 1155766004868 dimer interface [polypeptide binding]; other site 1155766004869 PYR/PP interface [polypeptide binding]; other site 1155766004870 TPP binding site [chemical binding]; other site 1155766004871 substrate binding site [chemical binding]; other site 1155766004872 Sen15 protein; Region: Sen15; cl09847 1155766004873 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 1155766004874 Domain of unknown function; Region: EKR; pfam10371 1155766004875 4Fe-4S binding domain; Region: Fer4_6; pfam12837 1155766004876 4Fe-4S binding domain; Region: Fer4; pfam00037 1155766004877 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 1155766004878 TPP-binding site [chemical binding]; other site 1155766004879 dimer interface [polypeptide binding]; other site 1155766004880 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1155766004881 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 1155766004882 catalytic residues [active] 1155766004883 potential frameshift: common BLAST hit: gi|320152782|ref|YP_004172605.1| integrase 1155766004884 Helix-turn-helix domain; Region: HTH_38; pfam13936 1155766004885 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1155766004886 Integrase core domain; Region: rve; pfam00665 1155766004887 Integrase core domain; Region: rve_3; cl15866 1155766004888 tandem five-transmembrane protein; Region: Gpos_tandem_5TM; TIGR01218 1155766004889 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 1155766004890 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 1155766004891 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 1155766004892 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 1155766004893 phosphate binding site [ion binding]; other site 1155766004894 putative substrate binding pocket [chemical binding]; other site 1155766004895 dimer interface [polypeptide binding]; other site 1155766004896 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 1155766004897 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 1155766004898 aspartate racemase; Region: asp_race; TIGR00035 1155766004899 Predicted ATP-grasp enzyme [General function prediction only]; Region: COG3919 1155766004900 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 1155766004901 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1155766004902 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1155766004903 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1155766004904 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1155766004905 excinuclease ABC subunit B; Provisional; Region: PRK05298 1155766004906 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1155766004907 ATP binding site [chemical binding]; other site 1155766004908 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1155766004909 nucleotide binding region [chemical binding]; other site 1155766004910 ATP-binding site [chemical binding]; other site 1155766004911 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1155766004912 UvrB/uvrC motif; Region: UVR; pfam02151 1155766004913 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1155766004914 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1155766004915 substrate binding pocket [chemical binding]; other site 1155766004916 membrane-bound complex binding site; other site 1155766004917 hinge residues; other site 1155766004918 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1155766004919 dimer interface [polypeptide binding]; other site 1155766004920 conserved gate region; other site 1155766004921 ABC-ATPase subunit interface; other site 1155766004922 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1155766004923 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1155766004924 Walker A/P-loop; other site 1155766004925 ATP binding site [chemical binding]; other site 1155766004926 Q-loop/lid; other site 1155766004927 ABC transporter signature motif; other site 1155766004928 Walker B; other site 1155766004929 D-loop; other site 1155766004930 H-loop/switch region; other site 1155766004931 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 1155766004932 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1155766004933 chaperone protein DnaJ; Provisional; Region: PRK14276 1155766004934 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1155766004935 HSP70 interaction site [polypeptide binding]; other site 1155766004936 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 1155766004937 substrate binding site [polypeptide binding]; other site 1155766004938 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1155766004939 Zn binding sites [ion binding]; other site 1155766004940 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1155766004941 substrate binding site [polypeptide binding]; other site 1155766004942 dimer interface [polypeptide binding]; other site 1155766004943 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1155766004944 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 1155766004945 nucleotide binding site [chemical binding]; other site 1155766004946 NEF interaction site [polypeptide binding]; other site 1155766004947 SBD interface [polypeptide binding]; other site 1155766004948 heat shock protein GrpE; Provisional; Region: PRK14140 1155766004949 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1155766004950 dimer interface [polypeptide binding]; other site 1155766004951 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1155766004952 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 1155766004953 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 1155766004954 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 1155766004955 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1155766004956 FeS/SAM binding site; other site 1155766004957 HemN C-terminal domain; Region: HemN_C; pfam06969 1155766004958 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_3; cd03140 1155766004959 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 1155766004960 conserved cys residue [active] 1155766004961 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 1155766004962 putative dimer interface [polypeptide binding]; other site 1155766004963 catalytic triad [active] 1155766004964 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 1155766004965 putative deacylase active site [active] 1155766004966 Domain of unknown function (DU1801); Region: DUF1801; cl17490 1155766004967 Helix-turn-helix domain; Region: HTH_17; pfam12728 1155766004968 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1155766004969 Sugar transport protein; Region: Sugar_transport; pfam06800 1155766004970 glucose-1-dehydrogenase; Provisional; Region: PRK08936 1155766004971 glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358 1155766004972 NAD binding site [chemical binding]; other site 1155766004973 homodimer interface [polypeptide binding]; other site 1155766004974 active site 1155766004975 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1155766004976 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 1155766004977 active site 1155766004978 Riboflavin kinase; Region: Flavokinase; pfam01687 1155766004979 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01550 1155766004980 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1155766004981 RNA binding site [nucleotide binding]; other site 1155766004982 active site 1155766004983 XFP C-terminal domain; Region: XFP_C; pfam09363 1155766004984 putative phosphoketolase; Provisional; Region: PRK05261 1155766004985 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 1155766004986 TPP-binding site; other site 1155766004987 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 1155766004988 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1155766004989 translation initiation factor IF-2; Region: IF-2; TIGR00487 1155766004990 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1155766004991 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1155766004992 G1 box; other site 1155766004993 putative GEF interaction site [polypeptide binding]; other site 1155766004994 GTP/Mg2+ binding site [chemical binding]; other site 1155766004995 Switch I region; other site 1155766004996 G2 box; other site 1155766004997 G3 box; other site 1155766004998 Switch II region; other site 1155766004999 G4 box; other site 1155766005000 G5 box; other site 1155766005001 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1155766005002 Translation-initiation factor 2; Region: IF-2; pfam11987 1155766005003 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1155766005004 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 1155766005005 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 1155766005006 putative RNA binding cleft [nucleotide binding]; other site 1155766005007 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 1155766005008 NusA N-terminal domain; Region: NusA_N; pfam08529 1155766005009 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1155766005010 RNA binding site [nucleotide binding]; other site 1155766005011 homodimer interface [polypeptide binding]; other site 1155766005012 NusA-like KH domain; Region: KH_5; pfam13184 1155766005013 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1155766005014 G-X-X-G motif; other site 1155766005015 ribosome maturation protein RimP; Reviewed; Region: PRK00092 1155766005016 Sm and related proteins; Region: Sm_like; cl00259 1155766005017 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 1155766005018 putative oligomer interface [polypeptide binding]; other site 1155766005019 putative RNA binding site [nucleotide binding]; other site 1155766005020 DNA polymerase III PolC; Validated; Region: polC; PRK00448 1155766005021 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 1155766005022 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 1155766005023 generic binding surface II; other site 1155766005024 generic binding surface I; other site 1155766005025 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 1155766005026 active site 1155766005027 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1155766005028 active site 1155766005029 catalytic site [active] 1155766005030 substrate binding site [chemical binding]; other site 1155766005031 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 1155766005032 prolyl-tRNA synthetase; Provisional; Region: PRK09194 1155766005033 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 1155766005034 dimer interface [polypeptide binding]; other site 1155766005035 motif 1; other site 1155766005036 active site 1155766005037 motif 2; other site 1155766005038 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 1155766005039 putative deacylase active site [active] 1155766005040 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1155766005041 active site 1155766005042 motif 3; other site 1155766005043 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 1155766005044 anticodon binding site; other site 1155766005045 RIP metalloprotease RseP; Region: TIGR00054 1155766005046 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1155766005047 active site 1155766005048 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1155766005049 protein binding site [polypeptide binding]; other site 1155766005050 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1155766005051 putative substrate binding region [chemical binding]; other site 1155766005052 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1155766005053 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 1155766005054 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 1155766005055 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 1155766005056 catalytic residue [active] 1155766005057 putative FPP diphosphate binding site; other site 1155766005058 putative FPP binding hydrophobic cleft; other site 1155766005059 dimer interface [polypeptide binding]; other site 1155766005060 putative IPP diphosphate binding site; other site 1155766005061 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1155766005062 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 1155766005063 hinge region; other site 1155766005064 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1155766005065 putative nucleotide binding site [chemical binding]; other site 1155766005066 uridine monophosphate binding site [chemical binding]; other site 1155766005067 homohexameric interface [polypeptide binding]; other site 1155766005068 elongation factor Ts; Provisional; Region: tsf; PRK09377 1155766005069 UBA/TS-N domain; Region: UBA; pfam00627 1155766005070 Elongation factor TS; Region: EF_TS; pfam00889 1155766005071 Elongation factor TS; Region: EF_TS; pfam00889 1155766005072 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1155766005073 rRNA interaction site [nucleotide binding]; other site 1155766005074 S8 interaction site; other site 1155766005075 putative laminin-1 binding site; other site 1155766005076 Arginine repressor [Transcription]; Region: ArgR; COG1438 1155766005077 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1155766005078 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1155766005079 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1155766005080 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1155766005081 catalytic residue [active] 1155766005082 phosphonoacetaldehyde hydrolase; Provisional; Region: PRK13478 1155766005083 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1155766005084 motif II; other site 1155766005085 arginyl-tRNA synthetase; Reviewed; Region: PRK12451 1155766005086 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 1155766005087 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1155766005088 active site 1155766005089 HIGH motif; other site 1155766005090 KMSK motif region; other site 1155766005091 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 1155766005092 tRNA binding surface [nucleotide binding]; other site 1155766005093 anticodon binding site; other site 1155766005094 carbamate kinase; Reviewed; Region: PRK12686 1155766005095 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 1155766005096 putative substrate binding site [chemical binding]; other site 1155766005097 nucleotide binding site [chemical binding]; other site 1155766005098 nucleotide binding site [chemical binding]; other site 1155766005099 homodimer interface [polypeptide binding]; other site 1155766005100 ornithine carbamoyltransferase; Validated; Region: PRK02102 1155766005101 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1155766005102 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1155766005103 arginine deiminase; Provisional; Region: PRK01388 1155766005104 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1155766005105 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1155766005106 ligand binding site [chemical binding]; other site 1155766005107 flexible hinge region; other site 1155766005108 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 1155766005109 UGMP family protein; Validated; Region: PRK09604 1155766005110 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1155766005111 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 1155766005112 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1155766005113 Coenzyme A binding pocket [chemical binding]; other site 1155766005114 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1155766005115 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 1155766005116 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1155766005117 Coenzyme A binding pocket [chemical binding]; other site 1155766005118 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1155766005119 Glycoprotease family; Region: Peptidase_M22; pfam00814 1155766005120 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1155766005121 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1155766005122 DNA binding site [nucleotide binding] 1155766005123 domain linker motif; other site 1155766005124 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 1155766005125 putative dimerization interface [polypeptide binding]; other site 1155766005126 putative ligand binding site [chemical binding]; other site 1155766005127 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 1155766005128 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 1155766005129 Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744 1155766005130 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 1155766005131 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 1155766005132 NAD binding site [chemical binding]; other site 1155766005133 homodimer interface [polypeptide binding]; other site 1155766005134 active site 1155766005135 substrate binding site [chemical binding]; other site 1155766005136 Protein of unknown function (DUF3042); Region: DUF3042; pfam11240 1155766005137 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 1155766005138 Uncharacterized conserved protein [Function unknown]; Region: COG3189 1155766005139 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1155766005140 active site residue [active] 1155766005141 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 1155766005142 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1155766005143 nucleotide binding site [chemical binding]; other site 1155766005144 Glucokinase; Region: Glucokinase; cl17310 1155766005145 Bacterial protein of unknown function (DUF910); Region: DUF910; pfam06014 1155766005146 Rhomboid family; Region: Rhomboid; pfam01694 1155766005147 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 1155766005148 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1155766005149 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1155766005150 ABC-ATPase subunit interface; other site 1155766005151 dimer interface [polypeptide binding]; other site 1155766005152 putative PBP binding regions; other site 1155766005153 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1155766005154 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1155766005155 ABC-ATPase subunit interface; other site 1155766005156 dimer interface [polypeptide binding]; other site 1155766005157 putative PBP binding regions; other site 1155766005158 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1155766005159 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1155766005160 Walker A/P-loop; other site 1155766005161 ATP binding site [chemical binding]; other site 1155766005162 Q-loop/lid; other site 1155766005163 ABC transporter signature motif; other site 1155766005164 Walker B; other site 1155766005165 D-loop; other site 1155766005166 H-loop/switch region; other site 1155766005167 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1155766005168 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1155766005169 intersubunit interface [polypeptide binding]; other site 1155766005170 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1155766005171 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1155766005172 folate binding site [chemical binding]; other site 1155766005173 NADP+ binding site [chemical binding]; other site 1155766005174 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 1155766005175 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4876 1155766005176 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 1155766005177 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1155766005178 Homeodomain-like domain; Region: HTH_23; pfam13384 1155766005179 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1155766005180 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 1155766005181 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1155766005182 active site 1155766005183 dimer interface [polypeptide binding]; other site 1155766005184 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1155766005185 Ligand Binding Site [chemical binding]; other site 1155766005186 Molecular Tunnel; other site 1155766005187 Transposase domain (DUF772); Region: DUF772; pfam05598 1155766005188 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1155766005189 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1155766005190 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 1155766005191 potential frameshift: common BLAST hit: gi|29377271|ref|NP_816425.1| ISEf1, transposase 1155766005192 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1155766005193 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1155766005194 MULE transposase domain; Region: MULE; pfam10551 1155766005195 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 1155766005196 active site 1155766005197 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1155766005198 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1155766005199 WHG domain; Region: WHG; pfam13305 1155766005200 Protein of unknown function (DUF1576); Region: DUF1576; pfam07613 1155766005201 Protein of unknown function (DUF1576); Region: DUF1576; pfam07613 1155766005202 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 1155766005203 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 1155766005204 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1155766005205 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1155766005206 Helix-turn-helix domain; Region: HTH_38; pfam13936 1155766005207 Integrase core domain; Region: rve; pfam00665 1155766005208 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1155766005209 Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; pfam10110 1155766005210 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1155766005211 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579 1155766005212 putative active site [active] 1155766005213 catalytic site [active] 1155766005214 putative metal binding site [ion binding]; other site 1155766005215 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1155766005216 Helix-turn-helix domain; Region: HTH_38; pfam13936 1155766005217 Integrase core domain; Region: rve; pfam00665 1155766005218 Integrase core domain; Region: rve_3; cl15866 1155766005219 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 1155766005220 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1155766005221 potential frameshift: common BLAST hit: gi|157691623|ref|YP_001486085.1| transposase 1155766005222 Transposase domain (DUF772); Region: DUF772; pfam05598 1155766005223 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1155766005224 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 1155766005225 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 1155766005226 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1155766005227 active site 1155766005228 dimer interface [polypeptide binding]; other site 1155766005229 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1155766005230 dimer interface [polypeptide binding]; other site 1155766005231 active site 1155766005232 glutamate dehydrogenase; Provisional; Region: PRK09414 1155766005233 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1155766005234 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 1155766005235 NAD(P) binding site [chemical binding]; other site 1155766005236 Predicted oxidoreductase [General function prediction only]; Region: COG3573 1155766005237 HI0933-like protein; Region: HI0933_like; pfam03486 1155766005238 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 1155766005239 putative deacylase active site [active] 1155766005240 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 1155766005241 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 1155766005242 active site 1155766005243 catalytic residue [active] 1155766005244 dimer interface [polypeptide binding]; other site 1155766005245 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 1155766005246 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 1155766005247 putative RNA binding site [nucleotide binding]; other site 1155766005248 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1155766005249 S-adenosylmethionine binding site [chemical binding]; other site 1155766005250 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 1155766005251 Sulfatase; Region: Sulfatase; pfam00884 1155766005252 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1155766005253 Q-loop/lid; other site 1155766005254 ABC transporter signature motif; other site 1155766005255 Walker B; other site 1155766005256 D-loop; other site 1155766005257 H-loop/switch region; other site 1155766005258 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1155766005259 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1155766005260 dimerization interface [polypeptide binding]; other site 1155766005261 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1155766005262 dimer interface [polypeptide binding]; other site 1155766005263 phosphorylation site [posttranslational modification] 1155766005264 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1155766005265 ATP binding site [chemical binding]; other site 1155766005266 Mg2+ binding site [ion binding]; other site 1155766005267 G-X-G motif; other site 1155766005268 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1155766005269 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1155766005270 active site 1155766005271 phosphorylation site [posttranslational modification] 1155766005272 intermolecular recognition site; other site 1155766005273 dimerization interface [polypeptide binding]; other site 1155766005274 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1155766005275 DNA binding site [nucleotide binding] 1155766005276 SdpI/YhfL protein family; Region: SdpI; pfam13630 1155766005277 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1155766005278 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1155766005279 active site 1155766005280 motif I; other site 1155766005281 motif II; other site 1155766005282 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1155766005283 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1155766005284 MULE transposase domain; Region: MULE; pfam10551 1155766005285 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 1155766005286 GAF domain; Region: GAF_2; pfam13185 1155766005287 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306 1155766005288 acetolactate synthase; Reviewed; Region: PRK08617 1155766005289 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1155766005290 PYR/PP interface [polypeptide binding]; other site 1155766005291 dimer interface [polypeptide binding]; other site 1155766005292 TPP binding site [chemical binding]; other site 1155766005293 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1155766005294 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 1155766005295 TPP-binding site [chemical binding]; other site 1155766005296 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1155766005297 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1155766005298 dimer interface [polypeptide binding]; other site 1155766005299 conserved gate region; other site 1155766005300 putative PBP binding loops; other site 1155766005301 ABC-ATPase subunit interface; other site 1155766005302 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1155766005303 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1155766005304 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1155766005305 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1155766005306 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 1155766005307 DNA binding residues [nucleotide binding] 1155766005308 putative dimer interface [polypeptide binding]; other site 1155766005309 benzoate transport; Region: 2A0115; TIGR00895 1155766005310 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1155766005311 putative substrate translocation pore; other site 1155766005312 HTH domain; Region: HTH_11; cl17392 1155766005313 Mga helix-turn-helix domain; Region: Mga; pfam05043 1155766005314 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 1155766005315 active site 1155766005316 catalytic site [active] 1155766005317 Cna protein B-type domain; Region: Cna_B; pfam05738 1155766005318 Cna protein B-type domain; Region: Cna_B; pfam05738 1155766005319 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 1155766005320 potential frameshift: common BLAST hit: gi|29375668|ref|NP_814822.1| cell wall surface anchor family protein 1155766005321 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 1155766005322 Cna protein B-type domain; Region: Cna_B; pfam05738 1155766005323 flagellin; Validated; Region: PRK08026 1155766005324 Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; pfam09860 1155766005325 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 1155766005326 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 1155766005327 Int/Topo IB signature motif; other site 1155766005328 Helix-turn-helix domain; Region: HTH_17; pfam12728 1155766005329 Helix-turn-helix domain; Region: HTH_16; pfam12645 1155766005330 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 1155766005331 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1155766005332 DNA binding residues [nucleotide binding] 1155766005333 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 1155766005334 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1155766005335 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 1155766005336 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1155766005337 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 1155766005338 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 1155766005339 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1155766005340 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1155766005341 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1155766005342 active site 1155766005343 metal binding site [ion binding]; metal-binding site 1155766005344 Glycosyl hydrolase family 32; Region: GH32_Aec43_like; cd08995 1155766005345 active site 1155766005346 Glycosyl hydrolases family 32; Region: Glyco_32; smart00640 1155766005347 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 1155766005348 active pocket/dimerization site; other site 1155766005349 active site 1155766005350 phosphorylation site [posttranslational modification] 1155766005351 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 1155766005352 active site 1155766005353 phosphorylation site [posttranslational modification] 1155766005354 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 1155766005355 PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609 1155766005356 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 1155766005357 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1155766005358 Walker A motif; other site 1155766005359 ATP binding site [chemical binding]; other site 1155766005360 Walker B motif; other site 1155766005361 arginine finger; other site 1155766005362 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 1155766005363 active site 1155766005364 active pocket/dimerization site; other site 1155766005365 phosphorylation site [posttranslational modification] 1155766005366 PRD domain; Region: PRD; pfam00874 1155766005367 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1155766005368 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1155766005369 nucleotide binding site [chemical binding]; other site 1155766005370 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 1155766005371 HPr interaction site; other site 1155766005372 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1155766005373 active site 1155766005374 phosphorylation site [posttranslational modification] 1155766005375 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 1155766005376 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1155766005377 active site turn [active] 1155766005378 phosphorylation site [posttranslational modification] 1155766005379 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1155766005380 Glycosyl hydrolases family 32; Region: Glyco_32; smart00640 1155766005381 Glycosyl hydrolase family 32; Region: GH32_Aec43_like; cd08995 1155766005382 active site 1155766005383 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1155766005384 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1155766005385 DNA binding site [nucleotide binding] 1155766005386 domain linker motif; other site 1155766005387 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 1155766005388 dimerization interface [polypeptide binding]; other site 1155766005389 ligand binding site [chemical binding]; other site 1155766005390 sodium binding site [ion binding]; other site 1155766005391 HTH-like domain; Region: HTH_21; pfam13276 1155766005392 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 1155766005393 Integrase core domain; Region: rve; pfam00665 1155766005394 Integrase core domain; Region: rve_3; pfam13683 1155766005395 Transposase; Region: HTH_Tnp_1; pfam01527 1155766005396 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1155766005397 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1155766005398 MarR family; Region: MarR_2; pfam12802 1155766005399 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1155766005400 Helix-turn-helix domain; Region: HTH_38; pfam13936 1155766005401 Integrase core domain; Region: rve; pfam00665 1155766005402 Integrase core domain; Region: rve_3; cl15866 1155766005403 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1155766005404 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 1155766005405 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1155766005406 Integrase core domain; Region: rve; pfam00665 1155766005407 transposase/IS protein; Provisional; Region: PRK09183 1155766005408 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1155766005409 Walker A motif; other site 1155766005410 ATP binding site [chemical binding]; other site 1155766005411 Walker B motif; other site 1155766005412 arginine finger; other site 1155766005413 Conjugative transposon protein TcpC; Region: TpcC; pfam12642 1155766005414 Lysozyme-like; Region: Lysozyme_like; pfam13702 1155766005415 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1155766005416 NlpC/P60 family; Region: NLPC_P60; pfam00877 1155766005417 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 1155766005418 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1155766005419 AAA-like domain; Region: AAA_10; pfam12846 1155766005420 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 1155766005421 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 1155766005422 putative active site [active] 1155766005423 putative NTP binding site [chemical binding]; other site 1155766005424 putative nucleic acid binding site [nucleotide binding]; other site 1155766005425 TcpE family; Region: TcpE; pfam12648 1155766005426 potential frameshift: common BLAST hit: gi|189218339|ref|YP_001938981.1| PHP family phosphoesterase fused to chromosome segregation ATPase 1155766005427 AAA domain; Region: AAA_21; pfam13304 1155766005428 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1155766005429 ABC transporter signature motif; other site 1155766005430 Walker B; other site 1155766005431 D-loop; other site 1155766005432 H-loop/switch region; other site 1155766005433 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 1155766005434 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 1155766005435 active site 1155766005436 AAA domain; Region: AAA_23; pfam13476 1155766005437 Antirestriction protein (ArdA); Region: ArdA; pfam07275 1155766005438 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 1155766005439 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 1155766005440 putative active site [active] 1155766005441 putative NTP binding site [chemical binding]; other site 1155766005442 putative nucleic acid binding site [nucleotide binding]; other site 1155766005443 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1155766005444 active site 1155766005445 Protein of unknown function (DUF3789); Region: DUF3789; pfam12664 1155766005446 potential frameshift: common BLAST hit: gi|29376839|ref|NP_815993.1| Cro/CI family transcriptional regulator 1155766005447 Replication initiation factor; Region: Rep_trans; pfam02486 1155766005448 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1155766005449 non-specific DNA binding site [nucleotide binding]; other site 1155766005450 salt bridge; other site 1155766005451 sequence-specific DNA binding site [nucleotide binding]; other site 1155766005452 C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145 1155766005453 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1155766005454 cofactor binding site; other site 1155766005455 DNA binding site [nucleotide binding] 1155766005456 substrate interaction site [chemical binding]; other site 1155766005457 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1155766005458 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1155766005459 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1155766005460 Walker A motif; other site 1155766005461 ATP binding site [chemical binding]; other site 1155766005462 Walker B motif; other site 1155766005463 arginine finger; other site 1155766005464 RelB antitoxin; Region: RelB; cl01171 1155766005465 Bacterial protein of unknown function (DUF961); Region: DUF961; pfam06125 1155766005466 Bacterial protein of unknown function (DUF961); Region: DUF961; pfam06125 1155766005467 Cna protein B-type domain; Region: Cna_B; pfam05738 1155766005468 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 1155766005469 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 1155766005470 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 1155766005471 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 1155766005472 RimM N-terminal domain; Region: RimM; pfam01782 1155766005473 PRC-barrel domain; Region: PRC; pfam05239 1155766005474 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 1155766005475 KH domain; Region: KH_4; pfam13083 1155766005476 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 1155766005477 Predicted flavoprotein [General function prediction only]; Region: COG0431 1155766005478 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1155766005479 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1155766005480 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl17426 1155766005481 folate binding site [chemical binding]; other site 1155766005482 NADP+ binding site [chemical binding]; other site 1155766005483 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 1155766005484 signal recognition particle protein; Provisional; Region: PRK10867 1155766005485 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1155766005486 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1155766005487 P loop; other site 1155766005488 GTP binding site [chemical binding]; other site 1155766005489 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1155766005490 putative DNA-binding protein; Validated; Region: PRK00118 1155766005491 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 1155766005492 Protein of unknown function (DUF523); Region: DUF523; pfam04463 1155766005493 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1155766005494 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1155766005495 active site 1155766005496 phosphorylation site [posttranslational modification] 1155766005497 intermolecular recognition site; other site 1155766005498 dimerization interface [polypeptide binding]; other site 1155766005499 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1155766005500 DNA binding site [nucleotide binding] 1155766005501 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1155766005502 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1155766005503 dimer interface [polypeptide binding]; other site 1155766005504 phosphorylation site [posttranslational modification] 1155766005505 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1155766005506 ATP binding site [chemical binding]; other site 1155766005507 Mg2+ binding site [ion binding]; other site 1155766005508 G-X-G motif; other site 1155766005509 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 1155766005510 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1155766005511 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1155766005512 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1155766005513 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1155766005514 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 1155766005515 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1155766005516 Homeodomain-like domain; Region: HTH_23; pfam13384 1155766005517 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1155766005518 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 1155766005519 phosphate binding protein; Region: ptsS_2; TIGR02136 1155766005520 SdpI/YhfL protein family; Region: SdpI; pfam13630 1155766005521 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1155766005522 MULE transposase domain; Region: MULE; pfam10551 1155766005523 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1155766005524 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1155766005525 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 1155766005526 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 1155766005527 active site 1155766005528 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1155766005529 Protein of unknown function (DUF4231); Region: DUF4231; pfam14015 1155766005530 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 1155766005531 HTH-like domain; Region: HTH_21; pfam13276 1155766005532 Integrase core domain; Region: rve; pfam00665 1155766005533 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1155766005534 Helix-turn-helix domain; Region: HTH_28; pfam13518 1155766005535 Helix-turn-helix domain; Region: HTH_28; pfam13518 1155766005536 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1155766005537 MULE transposase domain; Region: MULE; pfam10551 1155766005538 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1155766005539 Helix-turn-helix domain; Region: HTH_28; pfam13518 1155766005540 Helix-turn-helix domain; Region: HTH_28; pfam13518 1155766005541 putative transposase OrfB; Reviewed; Region: PHA02517 1155766005542 HTH-like domain; Region: HTH_21; pfam13276 1155766005543 Integrase core domain; Region: rve; pfam00665 1155766005544 Integrase core domain; Region: rve_2; pfam13333 1155766005545 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cl02712 1155766005546 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 1155766005547 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1155766005548 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1155766005549 Walker A motif; other site 1155766005550 ATP binding site [chemical binding]; other site 1155766005551 Walker B motif; other site 1155766005552 arginine finger; other site 1155766005553 Protein of unknown function DUF58; Region: DUF58; pfam01882 1155766005554 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1155766005555 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1155766005556 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 1155766005557 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 1155766005558 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1155766005559 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1155766005560 motif II; other site 1155766005561 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1155766005562 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1155766005563 metal-binding site [ion binding] 1155766005564 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1155766005565 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1155766005566 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1155766005567 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1155766005568 metal-binding site [ion binding] 1155766005569 copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698 1155766005570 Penicillinase repressor; Region: Pencillinase_R; pfam03965 1155766005571 topology modulation protein; Reviewed; Region: PRK08118 1155766005572 AAA domain; Region: AAA_17; pfam13207 1155766005573 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 1155766005574 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1155766005575 inner membrane transporter YjeM; Provisional; Region: PRK15238 1155766005576 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1155766005577 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1155766005578 metal-binding site [ion binding] 1155766005579 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1155766005580 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1155766005581 hypothetical protein; Provisional; Region: PRK11770 1155766005582 Domain of unknown function (DUF307); Region: DUF307; pfam03733 1155766005583 Domain of unknown function (DUF307); Region: DUF307; pfam03733 1155766005584 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_2; cd01834 1155766005585 active site 1155766005586 catalytic triad [active] 1155766005587 oxyanion hole [active] 1155766005588 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 1155766005589 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 1155766005590 putative dimer interface [polypeptide binding]; other site 1155766005591 putative anticodon binding site; other site 1155766005592 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 1155766005593 homodimer interface [polypeptide binding]; other site 1155766005594 motif 1; other site 1155766005595 motif 2; other site 1155766005596 active site 1155766005597 motif 3; other site 1155766005598 aspartate aminotransferase; Provisional; Region: PRK05764 1155766005599 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1155766005600 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1155766005601 homodimer interface [polypeptide binding]; other site 1155766005602 catalytic residue [active] 1155766005603 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 1155766005604 Endonuclease related to archaeal Holliday junction resolvase; Region: Endonuc_Holl; cl01958 1155766005605 DnaQ family exonuclease/DinG family helicase, putative; Region: dinG_rel; TIGR01407 1155766005606 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1155766005607 active site 1155766005608 catalytic site [active] 1155766005609 substrate binding site [chemical binding]; other site 1155766005610 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1155766005611 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12294 1155766005612 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1155766005613 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1155766005614 DNA-binding site [nucleotide binding]; DNA binding site 1155766005615 RNA-binding motif; other site 1155766005616 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 1155766005617 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1155766005618 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 1155766005619 Uncharacterized conserved protein [Function unknown]; Region: COG1434 1155766005620 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1155766005621 putative active site [active] 1155766005622 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 1155766005623 ClC sycA-like chloride channel proteins. This ClC family presents in bacteria, where it facilitates acid resistance in acidic soil. Mutation of this gene (sycA) in Rhizobium tropici CIAT899 causes serious deficiencies in nodule development, nodulation...; Region: ClC_sycA_like; cd03682 1155766005624 putative Cl- selectivity filter; other site 1155766005625 putative pore gating glutamate residue; other site 1155766005626 Fibronectin-binding protein (FBP); Region: FBP; pfam07299 1155766005627 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 1155766005628 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1155766005629 Zn2+ binding site [ion binding]; other site 1155766005630 Mg2+ binding site [ion binding]; other site 1155766005631 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 1155766005632 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 1155766005633 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1155766005634 Acylphosphatases [Energy production and conversion]; Region: AcyP; COG1254 1155766005635 OxaA-like protein precursor; Provisional; Region: PRK02463 1155766005636 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 1155766005637 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 1155766005638 active pocket/dimerization site; other site 1155766005639 active site 1155766005640 phosphorylation site [posttranslational modification] 1155766005641 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 1155766005642 PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609 1155766005643 PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830 1155766005644 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1155766005645 tagatose-6-phosphate kinase; Region: lacC; TIGR01231 1155766005646 putative substrate binding site [chemical binding]; other site 1155766005647 putative ATP binding site [chemical binding]; other site 1155766005648 tagatose 1,6-diphosphate aldolase; Reviewed; Region: PRK12399 1155766005649 putative sugar isomerase, AgaS family; Region: agaS_fam; TIGR02815 1155766005650 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1155766005651 dimer interface [polypeptide binding]; other site 1155766005652 active site 1155766005653 AgaS-like protein. AgaS contains a SIS (Sugar ISomerase) domain which is found in many phosphosugar isomerases and phosphosugar binding proteins. AgaS is a putative isomerase in Escherichia coli. It is similar to the glucosamine-6-phosphate synthases; Region: SIS_AgaS_like; cd05010 1155766005654 putative active site [active] 1155766005655 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1155766005656 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1155766005657 DNA-binding site [nucleotide binding]; DNA binding site 1155766005658 UTRA domain; Region: UTRA; pfam07702 1155766005659 Class I aldolases; Region: Aldolase_Class_I; cl17187 1155766005660 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1155766005661 active site 1155766005662 phosphorylation site [posttranslational modification] 1155766005663 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1155766005664 active site 1155766005665 P-loop; other site 1155766005666 phosphorylation site [posttranslational modification] 1155766005667 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 1155766005668 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 1155766005669 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1155766005670 putative substrate binding site [chemical binding]; other site 1155766005671 putative ATP binding site [chemical binding]; other site 1155766005672 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1155766005673 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1155766005674 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1155766005675 putative active site [active] 1155766005676 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1155766005677 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 1155766005678 Integrase core domain; Region: rve; pfam00665 1155766005679 Integrase core domain; Region: rve_3; cl15866 1155766005680 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1155766005681 Helix-turn-helix domain; Region: HTH_38; pfam13936 1155766005682 potential frameshift: common BLAST hit: gi|191637710|ref|YP_001986876.1| transposase 1155766005683 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1155766005684 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 1155766005685 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 1155766005686 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1155766005687 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 1155766005688 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1155766005689 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 1155766005690 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1155766005691 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1155766005692 Integrase core domain; Region: rve; pfam00665 1155766005693 Integrase core domain; Region: rve_3; cl15866 1155766005694 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1155766005695 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1155766005696 substrate binding site [chemical binding]; other site 1155766005697 ATP binding site [chemical binding]; other site 1155766005698 4-hydroxy-2-oxovalerate aldolase-like, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA_like; cd07944 1155766005699 active site 1155766005700 catalytic residues [active] 1155766005701 metal binding site [ion binding]; metal-binding site 1155766005702 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 1155766005703 ligand binding site; other site 1155766005704 tetramer interface; other site 1155766005705 potential frameshift: common BLAST hit: gi|221231231|ref|YP_002510383.1| capsule biosynthesis repeating unit flippase Wzx 1155766005706 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1155766005707 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1155766005708 Polysaccharide biosynthesis protein; Region: Polysacc_synt; cl10513 1155766005709 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1155766005710 active site 1155766005711 Capsular polysaccharide synthesis protein; Region: Caps_synth; pfam05704 1155766005712 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1155766005713 This family is most closely related to the GT1 family of glycosyltransferases. capH in Staphylococcus aureus has been shown to be required for the biosynthesis of the type 1 capsular polysaccharide (CP1); Region: GT1_CapH_like; cd03812 1155766005714 putative ADP-binding pocket [chemical binding]; other site 1155766005715 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1155766005716 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1155766005717 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 1155766005718 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1155766005719 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 1155766005720 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 1155766005721 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1155766005722 Chain length determinant protein; Region: Wzz; cl15801 1155766005723 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 1155766005724 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 1155766005725 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1155766005726 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 1155766005727 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1155766005728 MULE transposase domain; Region: MULE; pfam10551 1155766005729 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 1155766005730 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1155766005731 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 1155766005732 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1155766005733 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 1155766005734 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 1155766005735 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1155766005736 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 1155766005737 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 1155766005738 DALR anticodon binding domain; Region: DALR_1; pfam05746 1155766005739 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 1155766005740 dimer interface [polypeptide binding]; other site 1155766005741 motif 1; other site 1155766005742 active site 1155766005743 motif 2; other site 1155766005744 motif 3; other site 1155766005745 Recombination protein O N terminal; Region: RecO_N; pfam11967 1155766005746 DNA repair protein RecO; Region: reco; TIGR00613 1155766005747 Recombination protein O C terminal; Region: RecO_C; pfam02565 1155766005748 GTPase Era; Reviewed; Region: era; PRK00089 1155766005749 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1155766005750 G1 box; other site 1155766005751 GTP/Mg2+ binding site [chemical binding]; other site 1155766005752 Switch I region; other site 1155766005753 G2 box; other site 1155766005754 Switch II region; other site 1155766005755 G3 box; other site 1155766005756 G4 box; other site 1155766005757 G5 box; other site 1155766005758 KH domain; Region: KH_2; pfam07650 1155766005759 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 1155766005760 metal-binding heat shock protein; Provisional; Region: PRK00016 1155766005761 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 1155766005762 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1155766005763 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1155766005764 Zn2+ binding site [ion binding]; other site 1155766005765 Mg2+ binding site [ion binding]; other site 1155766005766 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1155766005767 PhoH-like protein; Region: PhoH; pfam02562 1155766005768 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 1155766005769 Yqey-like protein; Region: YqeY; pfam09424 1155766005770 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 1155766005771 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1155766005772 metal binding site 2 [ion binding]; metal-binding site 1155766005773 putative DNA binding helix; other site 1155766005774 metal binding site 1 [ion binding]; metal-binding site 1155766005775 dimer interface [polypeptide binding]; other site 1155766005776 structural Zn2+ binding site [ion binding]; other site 1155766005777 Kinase/pyrophosphorylase; Region: Kinase-PPPase; pfam03618 1155766005778 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1155766005779 dimerization interface [polypeptide binding]; other site 1155766005780 putative DNA binding site [nucleotide binding]; other site 1155766005781 putative Zn2+ binding site [ion binding]; other site 1155766005782 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 1155766005783 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 1155766005784 active site 1155766005785 substrate binding site [chemical binding]; other site 1155766005786 metal binding site [ion binding]; metal-binding site 1155766005787 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1155766005788 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1155766005789 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1155766005790 6-phospho-beta-glucosidase; Reviewed; Region: arb; PRK09593 1155766005791 beta-galactosidase; Region: BGL; TIGR03356 1155766005792 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 1155766005793 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 1155766005794 NAD binding site [chemical binding]; other site 1155766005795 sugar binding site [chemical binding]; other site 1155766005796 divalent metal binding site [ion binding]; other site 1155766005797 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1155766005798 dimer interface [polypeptide binding]; other site 1155766005799 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1155766005800 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1155766005801 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1155766005802 putative active site [active] 1155766005803 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 1155766005804 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 1155766005805 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1155766005806 active site turn [active] 1155766005807 phosphorylation site [posttranslational modification] 1155766005808 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1155766005809 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 1155766005810 HPr interaction site; other site 1155766005811 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1155766005812 active site 1155766005813 phosphorylation site [posttranslational modification] 1155766005814 transcriptional antiterminator BglG; Provisional; Region: PRK09772 1155766005815 CAT RNA binding domain; Region: CAT_RBD; smart01061 1155766005816 PRD domain; Region: PRD; pfam00874 1155766005817 PRD domain; Region: PRD; pfam00874 1155766005818 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1155766005819 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1155766005820 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1155766005821 Walker A/P-loop; other site 1155766005822 ATP binding site [chemical binding]; other site 1155766005823 Q-loop/lid; other site 1155766005824 ABC transporter signature motif; other site 1155766005825 Walker B; other site 1155766005826 D-loop; other site 1155766005827 H-loop/switch region; other site 1155766005828 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1155766005829 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 1155766005830 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1155766005831 Walker A/P-loop; other site 1155766005832 ATP binding site [chemical binding]; other site 1155766005833 Q-loop/lid; other site 1155766005834 ABC transporter signature motif; other site 1155766005835 Walker B; other site 1155766005836 D-loop; other site 1155766005837 H-loop/switch region; other site 1155766005838 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3763 1155766005839 manganese transport protein MntH; Reviewed; Region: PRK00701 1155766005840 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1155766005841 endonuclease IV; Provisional; Region: PRK01060 1155766005842 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 1155766005843 AP (apurinic/apyrimidinic) site pocket; other site 1155766005844 DNA interaction; other site 1155766005845 Metal-binding active site; metal-binding site 1155766005846 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 1155766005847 Transglycosylase; Region: Transgly; pfam00912 1155766005848 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1155766005849 catabolite control protein A; Region: ccpA; TIGR01481 1155766005850 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1155766005851 DNA binding site [nucleotide binding] 1155766005852 domain linker motif; other site 1155766005853 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 1155766005854 dimerization interface [polypeptide binding]; other site 1155766005855 effector binding site; other site 1155766005856 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1155766005857 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1155766005858 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1155766005859 active site 1155766005860 Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768 1155766005861 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1155766005862 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1155766005863 active site 1155766005864 tetramer interface; other site 1155766005865 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 1155766005866 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1155766005867 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1155766005868 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 1155766005869 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 1155766005870 HPr kinase/phosphorylase; Provisional; Region: PRK05428 1155766005871 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 1155766005872 Hpr binding site; other site 1155766005873 active site 1155766005874 homohexamer subunit interaction site [polypeptide binding]; other site 1155766005875 Membrane protein of unknown function; Region: DUF360; pfam04020 1155766005876 PspC domain; Region: PspC; pfam04024 1155766005877 Uncharacterized conserved protein [Function unknown]; Region: COG3595 1155766005878 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 1155766005879 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 1155766005880 YibE/F-like protein; Region: YibE_F; pfam07907 1155766005881 YibE/F-like protein; Region: YibE_F; pfam07907 1155766005882 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 1155766005883 PhoU domain; Region: PhoU; pfam01895 1155766005884 PhoU domain; Region: PhoU; pfam01895 1155766005885 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 1155766005886 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1155766005887 Walker A/P-loop; other site 1155766005888 ATP binding site [chemical binding]; other site 1155766005889 Q-loop/lid; other site 1155766005890 ABC transporter signature motif; other site 1155766005891 Walker B; other site 1155766005892 D-loop; other site 1155766005893 H-loop/switch region; other site 1155766005894 phosphate transporter ATP-binding protein; Provisional; Region: PRK14237 1155766005895 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1155766005896 Walker A/P-loop; other site 1155766005897 ATP binding site [chemical binding]; other site 1155766005898 Q-loop/lid; other site 1155766005899 ABC transporter signature motif; other site 1155766005900 Walker B; other site 1155766005901 D-loop; other site 1155766005902 H-loop/switch region; other site 1155766005903 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 1155766005904 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1155766005905 dimer interface [polypeptide binding]; other site 1155766005906 conserved gate region; other site 1155766005907 putative PBP binding loops; other site 1155766005908 ABC-ATPase subunit interface; other site 1155766005909 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 1155766005910 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1155766005911 dimer interface [polypeptide binding]; other site 1155766005912 conserved gate region; other site 1155766005913 putative PBP binding loops; other site 1155766005914 ABC-ATPase subunit interface; other site 1155766005915 phosphate binding protein; Region: ptsS_2; TIGR02136 1155766005916 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 1155766005917 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 1155766005918 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 1155766005919 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1155766005920 putative active site [active] 1155766005921 catalytic site [active] 1155766005922 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 1155766005923 putative active site [active] 1155766005924 catalytic site [active] 1155766005925 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 1155766005926 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 1155766005927 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 1155766005928 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1155766005929 Walker A/P-loop; other site 1155766005930 ATP binding site [chemical binding]; other site 1155766005931 Q-loop/lid; other site 1155766005932 ABC transporter signature motif; other site 1155766005933 Walker B; other site 1155766005934 D-loop; other site 1155766005935 H-loop/switch region; other site 1155766005936 peptide chain release factor 2; Provisional; Region: PRK05589 1155766005937 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1155766005938 RF-1 domain; Region: RF-1; pfam00472 1155766005939 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 1155766005940 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 1155766005941 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 1155766005942 nucleotide binding region [chemical binding]; other site 1155766005943 ATP-binding site [chemical binding]; other site 1155766005944 SEC-C motif; Region: SEC-C; pfam02810 1155766005945 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1155766005946 30S subunit binding site; other site 1155766005947 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 1155766005948 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1155766005949 active site 1155766005950 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 1155766005951 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1155766005952 ATP binding site [chemical binding]; other site 1155766005953 putative Mg++ binding site [ion binding]; other site 1155766005954 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1155766005955 nucleotide binding region [chemical binding]; other site 1155766005956 ATP-binding site [chemical binding]; other site 1155766005957 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 1155766005958 active site 1155766005959 P-loop; other site 1155766005960 phosphorylation site [posttranslational modification] 1155766005961 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1155766005962 Uncharacterized conserved protein [Function unknown]; Region: COG1739 1155766005963 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 1155766005964 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 1155766005965 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1155766005966 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1155766005967 DNA-binding site [nucleotide binding]; DNA binding site 1155766005968 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 1155766005969 Protein of unknown function (DUF2969); Region: DUF2969; pfam11184 1155766005970 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1155766005971 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1155766005972 nucleotide binding site [chemical binding]; other site 1155766005973 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1155766005974 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1155766005975 Coenzyme A binding pocket [chemical binding]; other site 1155766005976 Haemolytic domain; Region: Haemolytic; pfam01809 1155766005977 DNA-directed RNA polymerase subunit beta; Region: EpuA; pfam11772 1155766005978 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1155766005979 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1155766005980 hinge; other site 1155766005981 active site 1155766005982 conserved hypothetical integral membrane protein; Region: int_mem_ywzB; TIGR02327 1155766005983 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 1155766005984 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1155766005985 gamma subunit interface [polypeptide binding]; other site 1155766005986 epsilon subunit interface [polypeptide binding]; other site 1155766005987 LBP interface [polypeptide binding]; other site 1155766005988 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1155766005989 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1155766005990 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1155766005991 alpha subunit interaction interface [polypeptide binding]; other site 1155766005992 Walker A motif; other site 1155766005993 ATP binding site [chemical binding]; other site 1155766005994 Walker B motif; other site 1155766005995 inhibitor binding site; inhibition site 1155766005996 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1155766005997 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1155766005998 core domain interface [polypeptide binding]; other site 1155766005999 delta subunit interface [polypeptide binding]; other site 1155766006000 epsilon subunit interface [polypeptide binding]; other site 1155766006001 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1155766006002 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1155766006003 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 1155766006004 beta subunit interaction interface [polypeptide binding]; other site 1155766006005 Walker A motif; other site 1155766006006 ATP binding site [chemical binding]; other site 1155766006007 Walker B motif; other site 1155766006008 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1155766006009 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 1155766006010 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 1155766006011 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 1155766006012 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 1155766006013 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 1155766006014 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 1155766006015 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 1155766006016 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1155766006017 SmpB-tmRNA interface; other site 1155766006018 ribonuclease R; Region: RNase_R; TIGR02063 1155766006019 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 1155766006020 RNB domain; Region: RNB; pfam00773 1155766006021 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 1155766006022 RNA binding site [nucleotide binding]; other site 1155766006023 Esterase/lipase [General function prediction only]; Region: COG1647 1155766006024 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1155766006025 Preprotein translocase SecG subunit; Region: SecG; pfam03840 1155766006026 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1155766006027 Coenzyme A binding pocket [chemical binding]; other site 1155766006028 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1155766006029 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1155766006030 NH_3: A subgroup of nucleoside hydrolases. This group contains eukaryotic and bacterial proteins similar to nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes...; Region: nuc_hydro_3; cd02653 1155766006031 active site 1155766006032 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 1155766006033 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588 1155766006034 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 1155766006035 metal binding site [ion binding]; metal-binding site 1155766006036 dimer interface [polypeptide binding]; other site 1155766006037 enolase; Provisional; Region: eno; PRK00077 1155766006038 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1155766006039 dimer interface [polypeptide binding]; other site 1155766006040 metal binding site [ion binding]; metal-binding site 1155766006041 substrate binding pocket [chemical binding]; other site 1155766006042 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1155766006043 triosephosphate isomerase; Provisional; Region: PRK14565 1155766006044 substrate binding site [chemical binding]; other site 1155766006045 dimer interface [polypeptide binding]; other site 1155766006046 catalytic triad [active] 1155766006047 Phosphoglycerate kinase; Region: PGK; pfam00162 1155766006048 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 1155766006049 substrate binding site [chemical binding]; other site 1155766006050 hinge regions; other site 1155766006051 ADP binding site [chemical binding]; other site 1155766006052 catalytic site [active] 1155766006053 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1155766006054 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 1155766006055 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1155766006056 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 1155766006057 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1155766006058 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 1155766006059 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 1155766006060 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 1155766006061 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1155766006062 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 1155766006063 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 1155766006064 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1155766006065 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1155766006066 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1155766006067 DNA binding residues [nucleotide binding] 1155766006068 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066 1155766006069 Domain of unknown function (DUF1934); Region: DUF1934; pfam09148 1155766006070 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1155766006071 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 1155766006072 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1155766006073 Zn2+ binding site [ion binding]; other site 1155766006074 Mg2+ binding site [ion binding]; other site 1155766006075 sugar phosphate phosphatase; Provisional; Region: PRK10513 1155766006076 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1155766006077 active site 1155766006078 motif I; other site 1155766006079 motif II; other site 1155766006080 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1155766006081 Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684 1155766006082 nudix motif; other site 1155766006083 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1155766006084 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 1155766006085 dimer interface [polypeptide binding]; other site 1155766006086 active site 1155766006087 metal binding site [ion binding]; metal-binding site 1155766006088 glutathione binding site [chemical binding]; other site 1155766006089 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 1155766006090 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 1155766006091 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 1155766006092 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1155766006093 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1155766006094 DNA-binding site [nucleotide binding]; DNA binding site 1155766006095 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1155766006096 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1155766006097 homodimer interface [polypeptide binding]; other site 1155766006098 catalytic residue [active] 1155766006099 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 1155766006100 Cation transport protein; Region: TrkH; pfam02386 1155766006101 V-type ATP synthase subunit D; Reviewed; Region: PRK00373 1155766006102 V-type ATP synthase subunit B; Provisional; Region: PRK04196 1155766006103 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1155766006104 V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_B; cd01135 1155766006105 Walker A motif homologous position; other site 1155766006106 Walker B motif; other site 1155766006107 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1155766006108 V-type ATP synthase subunit A; Provisional; Region: PRK04192 1155766006109 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1155766006110 V/A-type ATP synthase catalytic subunit A. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_A; cd01134 1155766006111 Walker A motif/ATP binding site; other site 1155766006112 Walker B motif; other site 1155766006113 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1155766006114 V-type ATP synthase subunit F; Provisional; Region: PRK01395 1155766006115 Archaeal/vacuolar-type H+-ATPase subunit C [Energy production and conversion]; Region: NtpC; COG1527 1155766006116 V-type ATP synthase subunit C; Provisional; Region: PRK01198; cl00660 1155766006117 V-type ATP synthase subunit K; Validated; Region: PRK06558 1155766006118 ATP synthase subunit C; Region: ATP-synt_C; pfam00137 1155766006119 ATP synthase subunit C; Region: ATP-synt_C; pfam00137 1155766006120 V-type ATP synthase subunit I; Validated; Region: PRK05771 1155766006121 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 1155766006122 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 1155766006123 catalytic triad [active] 1155766006124 Firmicute fructose-1,6-bisphosphatase; Region: FBPase_2; pfam06874 1155766006125 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1155766006126 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 1155766006127 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 1155766006128 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1155766006129 Walker A/P-loop; other site 1155766006130 ATP binding site [chemical binding]; other site 1155766006131 Q-loop/lid; other site 1155766006132 ABC transporter signature motif; other site 1155766006133 Walker B; other site 1155766006134 D-loop; other site 1155766006135 H-loop/switch region; other site 1155766006136 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 1155766006137 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 1155766006138 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1155766006139 GIY-YIG motif/motif A; other site 1155766006140 active site 1155766006141 catalytic site [active] 1155766006142 putative DNA binding site [nucleotide binding]; other site 1155766006143 metal binding site [ion binding]; metal-binding site 1155766006144 UvrB/uvrC motif; Region: UVR; pfam02151 1155766006145 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1155766006146 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1155766006147 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1155766006148 catalytic residues [active] 1155766006149 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 1155766006150 MutS domain III; Region: MutS_III; pfam05192 1155766006151 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1155766006152 Walker A/P-loop; other site 1155766006153 ATP binding site [chemical binding]; other site 1155766006154 Q-loop/lid; other site 1155766006155 ABC transporter signature motif; other site 1155766006156 Walker B; other site 1155766006157 D-loop; other site 1155766006158 H-loop/switch region; other site 1155766006159 Smr domain; Region: Smr; pfam01713 1155766006160 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 1155766006161 Colicin V production protein; Region: Colicin_V; pfam02674 1155766006162 Cell division protein ZapA; Region: ZapA; cl01146 1155766006163 ribonuclease HIII; Provisional; Region: PRK00996 1155766006164 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 1155766006165 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 1155766006166 RNA/DNA hybrid binding site [nucleotide binding]; other site 1155766006167 active site 1155766006168 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1155766006169 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1155766006170 active site 1155766006171 metal binding site [ion binding]; metal-binding site 1155766006172 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1155766006173 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1155766006174 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1155766006175 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1155766006176 Walker A/P-loop; other site 1155766006177 ATP binding site [chemical binding]; other site 1155766006178 Q-loop/lid; other site 1155766006179 ABC transporter signature motif; other site 1155766006180 Walker B; other site 1155766006181 D-loop; other site 1155766006182 H-loop/switch region; other site 1155766006183 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1155766006184 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 1155766006185 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1155766006186 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1155766006187 Mga helix-turn-helix domain; Region: Mga; pfam05043 1155766006188 electron transport complex protein RnfC; Provisional; Region: PRK05035 1155766006189 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 1155766006190 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 1155766006191 WxL domain surface cell wall-binding; Region: WxL; pfam13731 1155766006192 L-lactate oxidase; Region: L_lactate_ox; TIGR02708 1155766006193 L-Lactate oxidase (LOX) FMN-binding domain. LOX is a member of the family of FMN-containing alpha-hydroxyacid oxidases and catalyzes the oxidation of l-lactate using molecular oxygen to generate pyruvate and H2O2. This family occurs in both prokaryotes...; Region: LOX_like_FMN; cd04737 1155766006194 teramer interface [polypeptide binding]; other site 1155766006195 active site 1155766006196 FMN binding site [chemical binding]; other site 1155766006197 catalytic residues [active] 1155766006198 malate dehydrogenase; Provisional; Region: PRK13529 1155766006199 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1155766006200 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 1155766006201 NAD(P) binding site [chemical binding]; other site 1155766006202 2-hydroxycarboxylate transporter family; Region: 2HCT; pfam03390 1155766006203 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1155766006204 Coenzyme A binding pocket [chemical binding]; other site 1155766006205 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1155766006206 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 1155766006207 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 1155766006208 oligomerization interface [polypeptide binding]; other site 1155766006209 Caudovirus prohead protease; Region: Peptidase_U35; pfam04586 1155766006210 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 1155766006211 Phage capsid family; Region: Phage_capsid; pfam05065 1155766006212 Phage portal protein; Region: Phage_portal; pfam04860 1155766006213 Phage-related protein [Function unknown]; Region: COG4695; cl01923 1155766006214 Phage Terminase; Region: Terminase_1; pfam03354 1155766006215 Phage terminase, small subunit; Region: Terminase_4; pfam05119 1155766006216 Protein of unknown function (DUF3206); Region: DUF3206; pfam11472 1155766006217 Virulence-associated protein E; Region: VirE; pfam05272 1155766006218 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 1155766006219 polymerase nucleotide-binding site; other site 1155766006220 DNA-binding residues [nucleotide binding]; DNA binding site 1155766006221 nucleotide binding site [chemical binding]; other site 1155766006222 primase nucleotide-binding site [nucleotide binding]; other site 1155766006223 Primase C terminal 1 (PriCT-1); Region: PriCT_1; pfam08708 1155766006224 potential frameshift: common BLAST hit: gi|94995297|ref|YP_603395.1| phage antirepressor protein 1155766006225 BRO family, N-terminal domain; Region: Bro-N; cl10591 1155766006226 Prophage antirepressor [Transcription]; Region: COG3617 1155766006227 BRO family, N-terminal domain; Region: Bro-N; smart01040 1155766006228 Helix-turn-helix domain; Region: HTH_17; cl17695 1155766006229 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1155766006230 non-specific DNA binding site [nucleotide binding]; other site 1155766006231 salt bridge; other site 1155766006232 sequence-specific DNA binding site [nucleotide binding]; other site 1155766006233 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1155766006234 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1155766006235 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 1155766006236 Int/Topo IB signature motif; other site 1155766006237 Domain of unknown function (DUF4062); Region: DUF4062; pfam13271 1155766006238 Domain of unknown function (DUF4062); Region: DUF4062; pfam13271 1155766006239 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 1155766006240 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 1155766006241 Uncharacterized membrane protein [Function unknown]; Region: COG3949 1155766006242 Helix-turn-helix domain; Region: HTH_17; pfam12728 1155766006243 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1155766006244 non-specific DNA binding site [nucleotide binding]; other site 1155766006245 salt bridge; other site 1155766006246 sequence-specific DNA binding site [nucleotide binding]; other site 1155766006247 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1155766006248 non-specific DNA binding site [nucleotide binding]; other site 1155766006249 salt bridge; other site 1155766006250 sequence-specific DNA binding site [nucleotide binding]; other site 1155766006251 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1155766006252 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 1155766006253 Int/Topo IB signature motif; other site 1155766006254 hypothetical protein; Provisional; Region: PRK13678 1155766006255 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 1155766006256 hypothetical protein; Provisional; Region: PRK05473 1155766006257 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; pfam13930 1155766006258 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 1155766006259 Uncharacterized conserved protein [Function unknown]; Region: COG2966 1155766006260 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 1155766006261 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 1155766006262 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1155766006263 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1155766006264 Walker A/P-loop; other site 1155766006265 ATP binding site [chemical binding]; other site 1155766006266 Q-loop/lid; other site 1155766006267 ABC transporter signature motif; other site 1155766006268 Walker B; other site 1155766006269 D-loop; other site 1155766006270 H-loop/switch region; other site 1155766006271 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 1155766006272 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1155766006273 active site 1155766006274 phosphorylation site [posttranslational modification] 1155766006275 intermolecular recognition site; other site 1155766006276 dimerization interface [polypeptide binding]; other site 1155766006277 LytTr DNA-binding domain; Region: LytTR; cl04498 1155766006278 Domain of unknown function (DUF1980); Region: DUF1980; cl01492 1155766006279 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1155766006280 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1155766006281 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1155766006282 Predicted permeases [General function prediction only]; Region: COG0701 1155766006283 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1155766006284 catalytic residues [active] 1155766006285 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 1155766006286 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 1155766006287 CoA binding domain; Region: CoA_binding; pfam02629 1155766006288 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1155766006289 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1155766006290 Walker A/P-loop; other site 1155766006291 ATP binding site [chemical binding]; other site 1155766006292 Q-loop/lid; other site 1155766006293 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1155766006294 ABC transporter signature motif; other site 1155766006295 Walker B; other site 1155766006296 D-loop; other site 1155766006297 ABC transporter; Region: ABC_tran_2; pfam12848 1155766006298 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1155766006299 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 1155766006300 Uncharacterized protein conserved in bacteria (DUF2264); Region: DUF2264; pfam10022 1155766006301 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 1155766006302 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1155766006303 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1155766006304 dimer interface [polypeptide binding]; other site 1155766006305 conserved gate region; other site 1155766006306 putative PBP binding loops; other site 1155766006307 ABC-ATPase subunit interface; other site 1155766006308 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1155766006309 dimer interface [polypeptide binding]; other site 1155766006310 conserved gate region; other site 1155766006311 putative PBP binding loops; other site 1155766006312 ABC-ATPase subunit interface; other site 1155766006313 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1155766006314 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1155766006315 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1155766006316 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1155766006317 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 1155766006318 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1155766006319 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1155766006320 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1155766006321 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 1155766006322 active site residue [active] 1155766006323 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1155766006324 Helix-turn-helix domain; Region: HTH_38; pfam13936 1155766006325 Integrase core domain; Region: rve; pfam00665 1155766006326 Integrase core domain; Region: rve_3; cl15866 1155766006327 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 1155766006328 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1155766006329 HflX GTPase family; Region: HflX; cd01878 1155766006330 G1 box; other site 1155766006331 GTP/Mg2+ binding site [chemical binding]; other site 1155766006332 Switch I region; other site 1155766006333 G2 box; other site 1155766006334 G3 box; other site 1155766006335 Switch II region; other site 1155766006336 G4 box; other site 1155766006337 G5 box; other site 1155766006338 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1155766006339 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 1155766006340 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1155766006341 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 1155766006342 active site 1155766006343 catalytic site [active] 1155766006344 metal binding site [ion binding]; metal-binding site 1155766006345 dimer interface [polypeptide binding]; other site 1155766006346 Clp protease; Region: CLP_protease; pfam00574 1155766006347 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1155766006348 oligomer interface [polypeptide binding]; other site 1155766006349 active site residues [active] 1155766006350 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 1155766006351 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 1155766006352 trimer interface [polypeptide binding]; other site 1155766006353 putative metal binding site [ion binding]; other site 1155766006354 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1155766006355 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1155766006356 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1155766006357 Walker A/P-loop; other site 1155766006358 ATP binding site [chemical binding]; other site 1155766006359 Q-loop/lid; other site 1155766006360 ABC transporter signature motif; other site 1155766006361 Walker B; other site 1155766006362 D-loop; other site 1155766006363 H-loop/switch region; other site 1155766006364 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1155766006365 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1155766006366 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1155766006367 Walker A/P-loop; other site 1155766006368 ATP binding site [chemical binding]; other site 1155766006369 Q-loop/lid; other site 1155766006370 ABC transporter signature motif; other site 1155766006371 Walker B; other site 1155766006372 D-loop; other site 1155766006373 H-loop/switch region; other site 1155766006374 Protein of unknown function (DUF1447); Region: DUF1447; pfam07288 1155766006375 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1155766006376 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1155766006377 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1155766006378 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1155766006379 DNA-binding site [nucleotide binding]; DNA binding site 1155766006380 RNA-binding motif; other site 1155766006381 hypothetical protein; Reviewed; Region: PRK00024 1155766006382 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 1155766006383 MPN+ (JAMM) motif; other site 1155766006384 Zinc-binding site [ion binding]; other site 1155766006385 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 1155766006386 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1155766006387 motif II; other site 1155766006388 folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499 1155766006389 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1155766006390 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1155766006391 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 1155766006392 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1155766006393 active site 1155766006394 HIGH motif; other site 1155766006395 nucleotide binding site [chemical binding]; other site 1155766006396 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1155766006397 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1155766006398 active site 1155766006399 KMSKS motif; other site 1155766006400 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1155766006401 tRNA binding surface [nucleotide binding]; other site 1155766006402 anticodon binding site; other site 1155766006403 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 1155766006404 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 1155766006405 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 1155766006406 CoA binding domain; Region: CoA_binding; pfam02629 1155766006407 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 1155766006408 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 1155766006409 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 1155766006410 Ligand Binding Site [chemical binding]; other site 1155766006411 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1155766006412 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1155766006413 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1155766006414 catalytic residue [active] 1155766006415 Septation ring formation regulator, EzrA; Region: EzrA; pfam06160 1155766006416 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4696 1155766006417 metal binding site [ion binding]; metal-binding site 1155766006418 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1155766006419 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1155766006420 active site 1155766006421 motif I; other site 1155766006422 motif II; other site 1155766006423 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1155766006424 Protein of unknown function DUF72; Region: DUF72; pfam01904 1155766006425 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 1155766006426 active site 1155766006427 homotetramer interface [polypeptide binding]; other site 1155766006428 homodimer interface [polypeptide binding]; other site 1155766006429 Acyl-ACP thioesterase; Region: Acyl-ACP_TE; pfam01643 1155766006430 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1155766006431 active site 1155766006432 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1155766006433 active site 2 [active] 1155766006434 Phosphotransferase enzyme family; Region: APH; pfam01636 1155766006435 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1155766006436 active site 1155766006437 ATP binding site [chemical binding]; other site 1155766006438 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1155766006439 substrate binding site [chemical binding]; other site 1155766006440 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 1155766006441 trimer interface [polypeptide binding]; other site 1155766006442 active site 1155766006443 G bulge; other site 1155766006444 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1155766006445 Serine hydrolase; Region: Ser_hydrolase; cl17834 1155766006446 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4918 1155766006447 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1155766006448 Transposase; Region: HTH_Tnp_1; pfam01527 1155766006449 putative transposase OrfB; Reviewed; Region: PHA02517 1155766006450 HTH-like domain; Region: HTH_21; pfam13276 1155766006451 Integrase core domain; Region: rve; pfam00665 1155766006452 Integrase core domain; Region: rve_2; pfam13333 1155766006453 Predicted RNA binding protein (contains ribosomal protein S1 domain) [Translation, ribosomal structure and biogenesis]; Region: VacB; COG1098 1155766006454 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1155766006455 RNA binding site [nucleotide binding]; other site 1155766006456 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 1155766006457 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1155766006458 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1155766006459 homodimer interface [polypeptide binding]; other site 1155766006460 catalytic residue [active] 1155766006461 Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family [Posttranslational modification, protein turnover, chaperones]; Region: PpiB; COG0652 1155766006462 active site 1155766006463 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 1155766006464 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1155766006465 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 1155766006466 tetramer interfaces [polypeptide binding]; other site 1155766006467 binuclear metal-binding site [ion binding]; other site 1155766006468 Protein of unknown function (DUF1461); Region: DUF1461; pfam07314 1155766006469 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 1155766006470 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1155766006471 active site 1155766006472 motif I; other site 1155766006473 motif II; other site 1155766006474 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1155766006475 Protein of unknown function (DUF1027); Region: DUF1027; pfam06265 1155766006476 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1155766006477 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 1155766006478 active site 1155766006479 metal binding site [ion binding]; metal-binding site 1155766006480 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1155766006481 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1155766006482 nucleoside/Zn binding site; other site 1155766006483 dimer interface [polypeptide binding]; other site 1155766006484 catalytic motif [active] 1155766006485 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1155766006486 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 1155766006487 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1155766006488 S-adenosylmethionine binding site [chemical binding]; other site 1155766006489 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 1155766006490 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1155766006491 Mga helix-turn-helix domain; Region: Mga; pfam05043 1155766006492 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298 1155766006493 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 1155766006494 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 1155766006495 PhnA protein; Region: PhnA; pfam03831 1155766006496 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 1155766006497 DHH family; Region: DHH; pfam01368 1155766006498 DHHA1 domain; Region: DHHA1; pfam02272 1155766006499 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 1155766006500 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1155766006501 DNA-binding site [nucleotide binding]; DNA binding site 1155766006502 DRTGG domain; Region: DRTGG; pfam07085 1155766006503 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 1155766006504 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 1155766006505 active site 2 [active] 1155766006506 active site 1 [active] 1155766006507 metal-dependent hydrolase; Provisional; Region: PRK00685 1155766006508 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1155766006509 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 1155766006510 putative deacylase active site [active] 1155766006511 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1155766006512 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1155766006513 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1155766006514 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1155766006515 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1155766006516 FtsX-like permease family; Region: FtsX; pfam02687 1155766006517 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1155766006518 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 1155766006519 Walker A/P-loop; other site 1155766006520 ATP binding site [chemical binding]; other site 1155766006521 Q-loop/lid; other site 1155766006522 ABC transporter signature motif; other site 1155766006523 Walker B; other site 1155766006524 D-loop; other site 1155766006525 H-loop/switch region; other site 1155766006526 CsbD-like; Region: CsbD; cl17424 1155766006527 Isoaspartyl dipeptidase hydrolyzes the beta-L-isoaspartyl linkages in dipeptides, as part of the degradative pathway to eliminate proteins with beta-L-isoaspartyl peptide bonds, bonds whereby the beta-group of an aspartate forms the peptide link with the...; Region: Isoaspartyl-dipeptidase; cd01308 1155766006528 isoaspartyl dipeptidase; Provisional; Region: PRK10657 1155766006529 dimer interface [polypeptide binding]; other site 1155766006530 active site 1155766006531 Predicted membrane protein [Function unknown]; Region: COG1288; cl17886 1155766006532 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 1155766006533 hypothetical protein; Provisional; Region: PRK11588 1155766006534 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1155766006535 putative active site [active] 1155766006536 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 1155766006537 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1155766006538 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1155766006539 active site 1155766006540 tetramer interface; other site 1155766006541 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 1155766006542 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1155766006543 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1155766006544 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 1155766006545 A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710 1155766006546 putative active site [active] 1155766006547 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 1155766006548 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 1155766006549 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1155766006550 dimer interface [polypeptide binding]; other site 1155766006551 active site 1155766006552 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1155766006553 dimer interface [polypeptide binding]; other site 1155766006554 active site 1155766006555 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 1155766006556 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 1155766006557 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 1155766006558 active site 1155766006559 phosphorylation site [posttranslational modification] 1155766006560 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 1155766006561 active pocket/dimerization site; other site 1155766006562 active site 1155766006563 phosphorylation site [posttranslational modification] 1155766006564 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 1155766006565 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1155766006566 Walker A motif; other site 1155766006567 ATP binding site [chemical binding]; other site 1155766006568 Walker B motif; other site 1155766006569 arginine finger; other site 1155766006570 Transcriptional antiterminator [Transcription]; Region: COG3933 1155766006571 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 1155766006572 active pocket/dimerization site; other site 1155766006573 active site 1155766006574 phosphorylation site [posttranslational modification] 1155766006575 PRD domain; Region: PRD; pfam00874 1155766006576 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1155766006577 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1155766006578 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1155766006579 Walker A/P-loop; other site 1155766006580 ATP binding site [chemical binding]; other site 1155766006581 Q-loop/lid; other site 1155766006582 ABC transporter signature motif; other site 1155766006583 Walker B; other site 1155766006584 D-loop; other site 1155766006585 H-loop/switch region; other site 1155766006586 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1155766006587 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1155766006588 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1155766006589 Walker A/P-loop; other site 1155766006590 ATP binding site [chemical binding]; other site 1155766006591 Q-loop/lid; other site 1155766006592 ABC transporter signature motif; other site 1155766006593 Walker B; other site 1155766006594 D-loop; other site 1155766006595 H-loop/switch region; other site 1155766006596 hypothetical protein; Provisional; Region: PRK09609 1155766006597 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 1155766006598 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 1155766006599 active site 1155766006600 dimer interfaces [polypeptide binding]; other site 1155766006601 catalytic residues [active] 1155766006602 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1155766006603 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1155766006604 Walker A/P-loop; other site 1155766006605 ATP binding site [chemical binding]; other site 1155766006606 Q-loop/lid; other site 1155766006607 ABC transporter signature motif; other site 1155766006608 Walker B; other site 1155766006609 D-loop; other site 1155766006610 H-loop/switch region; other site 1155766006611 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 1155766006612 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1155766006613 S-adenosylmethionine binding site [chemical binding]; other site 1155766006614 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 1155766006615 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 1155766006616 putative active site [active] 1155766006617 putative metal binding site [ion binding]; other site 1155766006618 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 1155766006619 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 1155766006620 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1155766006621 active site 1155766006622 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1155766006623 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 1155766006624 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1155766006625 active site 1155766006626 HIGH motif; other site 1155766006627 KMSKS motif; other site 1155766006628 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1155766006629 tRNA binding surface [nucleotide binding]; other site 1155766006630 anticodon binding site; other site 1155766006631 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 1155766006632 dimer interface [polypeptide binding]; other site 1155766006633 putative tRNA-binding site [nucleotide binding]; other site 1155766006634 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 1155766006635 nudix motif; other site 1155766006636 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1155766006637 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1155766006638 Probable transposase; Region: OrfB_IS605; pfam01385 1155766006639 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1155766006640 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1155766006641 Walker A/P-loop; other site 1155766006642 ATP binding site [chemical binding]; other site 1155766006643 Q-loop/lid; other site 1155766006644 ABC transporter signature motif; other site 1155766006645 Walker B; other site 1155766006646 D-loop; other site 1155766006647 H-loop/switch region; other site 1155766006648 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1155766006649 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1155766006650 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1155766006651 Walker A/P-loop; other site 1155766006652 ATP binding site [chemical binding]; other site 1155766006653 Q-loop/lid; other site 1155766006654 ABC transporter signature motif; other site 1155766006655 Walker B; other site 1155766006656 D-loop; other site 1155766006657 H-loop/switch region; other site 1155766006658 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1155766006659 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1155766006660 dipeptide transporter; Provisional; Region: PRK10913 1155766006661 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1155766006662 dimer interface [polypeptide binding]; other site 1155766006663 conserved gate region; other site 1155766006664 putative PBP binding loops; other site 1155766006665 ABC-ATPase subunit interface; other site 1155766006666 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1155766006667 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1155766006668 dimer interface [polypeptide binding]; other site 1155766006669 conserved gate region; other site 1155766006670 putative PBP binding loops; other site 1155766006671 ABC-ATPase subunit interface; other site 1155766006672 Domain of unknown function (DUF3899); Region: DUF3899; pfam13038 1155766006673 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1155766006674 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1155766006675 peptide binding site [polypeptide binding]; other site 1155766006676 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1155766006677 Coenzyme A binding pocket [chemical binding]; other site 1155766006678 Glycerol dehydrogenase-like; Region: GlyDH-like2; cd08171 1155766006679 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 1155766006680 putative active site [active] 1155766006681 metal binding site [ion binding]; metal-binding site 1155766006682 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 1155766006683 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1155766006684 FeS/SAM binding site; other site 1155766006685 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1155766006686 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1155766006687 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 1155766006688 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 1155766006689 beta-galactosidase; Region: BGL; TIGR03356 1155766006690 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1155766006691 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1155766006692 substrate binding pocket [chemical binding]; other site 1155766006693 membrane-bound complex binding site; other site 1155766006694 hinge residues; other site 1155766006695 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1155766006696 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1155766006697 Walker A/P-loop; other site 1155766006698 ATP binding site [chemical binding]; other site 1155766006699 Q-loop/lid; other site 1155766006700 ABC transporter signature motif; other site 1155766006701 Walker B; other site 1155766006702 D-loop; other site 1155766006703 H-loop/switch region; other site 1155766006704 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1155766006705 dimer interface [polypeptide binding]; other site 1155766006706 conserved gate region; other site 1155766006707 putative PBP binding loops; other site 1155766006708 ABC-ATPase subunit interface; other site 1155766006709 This CD includes bacterial (Agrobacterium tumefaciens and Caulobacter crescentus ProX, and Clostridium sticklandii PrdX) and eukaryotic (Plasmodium falciparum N-terminal ProRS editing domain) sequences. The C. sticklandii PrdX protein, a homolog of the...; Region: PrdX_deacylase; cd04335 1155766006710 putative deacylase active site [active] 1155766006711 Collagen binding domain; Region: Collagen_bind; pfam05737 1155766006712 Cna protein B-type domain; Region: Cna_B; pfam05738 1155766006713 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 1155766006714 domain interaction interfaces [polypeptide binding]; other site 1155766006715 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 1155766006716 domain interaction interfaces [polypeptide binding]; other site 1155766006717 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 1155766006718 Enterocin A Immunity; Region: EntA_Immun; pfam08951 1155766006719 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1155766006720 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1155766006721 CAAX protease self-immunity; Region: Abi; cl00558 1155766006722 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1155766006723 active site 1155766006724 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 1155766006725 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1155766006726 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1155766006727 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1155766006728 dimer interface [polypeptide binding]; other site 1155766006729 active site 1155766006730 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1155766006731 folate binding site [chemical binding]; other site 1155766006732 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 1155766006733 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 1155766006734 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 1155766006735 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1155766006736 peptide chain release factor 1; Validated; Region: prfA; PRK00591 1155766006737 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1155766006738 RF-1 domain; Region: RF-1; pfam00472 1155766006739 thymidine kinase; Provisional; Region: PRK04296 1155766006740 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1155766006741 ATP binding site [chemical binding]; other site 1155766006742 Walker A motif; other site 1155766006743 Walker B motif; other site 1155766006744 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1155766006745 Coenzyme A binding pocket [chemical binding]; other site 1155766006746 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1155766006747 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1155766006748 S-adenosylmethionine binding site [chemical binding]; other site 1155766006749 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1155766006750 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1155766006751 Catalytic site [active] 1155766006752 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1155766006753 Uncharacterized BCR, COG1636; Region: DUF208; pfam02677 1155766006754 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 1155766006755 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 1155766006756 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 1155766006757 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1155766006758 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 1155766006759 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 1155766006760 catalytic triad [active] 1155766006761 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 1155766006762 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1155766006763 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1155766006764 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1155766006765 active site 1155766006766 phosphorylation site [posttranslational modification] 1155766006767 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 1155766006768 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 1155766006769 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 1155766006770 active site 1155766006771 P-loop; other site 1155766006772 phosphorylation site [posttranslational modification] 1155766006773 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 1155766006774 active site 1155766006775 P-loop; other site 1155766006776 phosphorylation site [posttranslational modification] 1155766006777 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1155766006778 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1155766006779 Walker A/P-loop; other site 1155766006780 ATP binding site [chemical binding]; other site 1155766006781 Q-loop/lid; other site 1155766006782 ABC transporter signature motif; other site 1155766006783 Walker B; other site 1155766006784 D-loop; other site 1155766006785 H-loop/switch region; other site 1155766006786 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1155766006787 active site 1155766006788 phosphorylation site [posttranslational modification] 1155766006789 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1155766006790 HTH domain; Region: HTH_11; pfam08279 1155766006791 HTH domain; Region: HTH_11; pfam08279 1155766006792 PRD domain; Region: PRD; pfam00874 1155766006793 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1155766006794 P-loop; other site 1155766006795 active site 1155766006796 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 1155766006797 active site 1155766006798 phosphorylation site [posttranslational modification] 1155766006799 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 1155766006800 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 1155766006801 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 1155766006802 active site 1155766006803 P-loop; other site 1155766006804 phosphorylation site [posttranslational modification] 1155766006805 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 1155766006806 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 1155766006807 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 1155766006808 Beta-lactamase; Region: Beta-lactamase; pfam00144 1155766006809 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1155766006810 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1155766006811 active site 1155766006812 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1155766006813 active site 1155766006814 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1155766006815 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1155766006816 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1155766006817 Walker A/P-loop; other site 1155766006818 ATP binding site [chemical binding]; other site 1155766006819 Q-loop/lid; other site 1155766006820 ABC transporter signature motif; other site 1155766006821 Walker B; other site 1155766006822 D-loop; other site 1155766006823 H-loop/switch region; other site 1155766006824 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1155766006825 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1155766006826 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1155766006827 Walker A/P-loop; other site 1155766006828 ATP binding site [chemical binding]; other site 1155766006829 Q-loop/lid; other site 1155766006830 ABC transporter signature motif; other site 1155766006831 Walker B; other site 1155766006832 D-loop; other site 1155766006833 H-loop/switch region; other site 1155766006834 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1155766006835 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1155766006836 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1155766006837 active site residue [active] 1155766006838 azoreductase; Reviewed; Region: PRK00170 1155766006839 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1155766006840 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1155766006841 PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; cl01516 1155766006842 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 1155766006843 Sulfatase; Region: Sulfatase; pfam00884 1155766006844 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1155766006845 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1155766006846 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1155766006847 NAD binding site [chemical binding]; other site 1155766006848 L-arabinose isomerase; Provisional; Region: PRK02929 1155766006849 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 1155766006850 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1155766006851 trimer interface [polypeptide binding]; other site 1155766006852 substrate binding site [chemical binding]; other site 1155766006853 Mn binding site [ion binding]; other site 1155766006854 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 1155766006855 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 1155766006856 intersubunit interface [polypeptide binding]; other site 1155766006857 active site 1155766006858 Zn2+ binding site [ion binding]; other site 1155766006859 L-ribulokinase-like proteins; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-RBK_like; cd07778 1155766006860 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 1155766006861 putative N- and C-terminal domain interface [polypeptide binding]; other site 1155766006862 putative active site [active] 1155766006863 MgATP binding site [chemical binding]; other site 1155766006864 catalytic site [active] 1155766006865 metal binding site [ion binding]; metal-binding site 1155766006866 putative carbohydrate binding site [chemical binding]; other site 1155766006867 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 1155766006868 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1155766006869 putative substrate translocation pore; other site 1155766006870 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1155766006871 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1155766006872 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1155766006873 DNA-binding site [nucleotide binding]; DNA binding site 1155766006874 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 1155766006875 Ligand-binding domain of DNA transcription repressor specific for arabinose (AraR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AraR; cd01541 1155766006876 putative dimerization interface [polypeptide binding]; other site 1155766006877 putative ligand binding site [chemical binding]; other site 1155766006878 Glycosyl hydrolase family 43; Region: GH43_1; cd08980 1155766006879 active site 1155766006880 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 1155766006881 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; smart00813 1155766006882 Protein of unknown function, DUF624; Region: DUF624; pfam04854 1155766006883 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1155766006884 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1155766006885 dimer interface [polypeptide binding]; other site 1155766006886 conserved gate region; other site 1155766006887 putative PBP binding loops; other site 1155766006888 ABC-ATPase subunit interface; other site 1155766006889 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1155766006890 dimer interface [polypeptide binding]; other site 1155766006891 conserved gate region; other site 1155766006892 putative PBP binding loops; other site 1155766006893 ABC-ATPase subunit interface; other site 1155766006894 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1155766006895 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1155766006896 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 1155766006897 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 1155766006898 Predicted transcriptional regulator [Transcription]; Region: COG4189 1155766006899 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1155766006900 putative DNA binding site [nucleotide binding]; other site 1155766006901 dimerization interface [polypeptide binding]; other site 1155766006902 putative Zn2+ binding site [ion binding]; other site 1155766006903 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 1155766006904 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1155766006905 homodimer interface [polypeptide binding]; other site 1155766006906 NAD binding pocket [chemical binding]; other site 1155766006907 ATP binding pocket [chemical binding]; other site 1155766006908 Mg binding site [ion binding]; other site 1155766006909 active-site loop [active] 1155766006910 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 1155766006911 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 1155766006912 active site 1155766006913 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 1155766006914 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1155766006915 DNA binding residues [nucleotide binding] 1155766006916 dimer interface [polypeptide binding]; other site 1155766006917 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 1155766006918 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1155766006919 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1155766006920 DNA binding site [nucleotide binding] 1155766006921 domain linker motif; other site 1155766006922 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 1155766006923 putative ligand binding site [chemical binding]; other site 1155766006924 putative dimerization interface [polypeptide binding]; other site 1155766006925 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1155766006926 MULE transposase domain; Region: MULE; pfam10551 1155766006927 Abi-like protein; Region: Abi_2; pfam07751 1155766006928 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1155766006929 amidase catalytic site [active] 1155766006930 Zn binding residues [ion binding]; other site 1155766006931 substrate binding site [chemical binding]; other site 1155766006932 Phage uncharacterized protein (Phage_XkdX); Region: Phage_XkdX; pfam09693 1155766006933 rod shape-determining protein MreC; Provisional; Region: PRK13922 1155766006934 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 1155766006935 Phage-related protein [Function unknown]; Region: COG4722 1155766006936 Phage tail protein; Region: Sipho_tail; cl17486 1155766006937 Phage-related minor tail protein [Function unknown]; Region: COG5281 1155766006938 Phage-related minor tail protein [Function unknown]; Region: COG5280 1155766006939 membrane protein P6; Region: PHA01399 1155766006940 Phage capsid family; Region: Phage_capsid; pfam05065 1155766006941 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 1155766006942 oligomer interface [polypeptide binding]; other site 1155766006943 active site residues [active] 1155766006944 Phage portal protein; Region: Phage_portal; pfam04860 1155766006945 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 1155766006946 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1155766006947 active site 1155766006948 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 1155766006949 Protein of unknown function (DUF1642); Region: DUF1642; pfam07852 1155766006950 YopX protein; Region: YopX; pfam09643 1155766006951 Protein of unknown function (DUF1140); Region: DUF1140; pfam06600 1155766006952 Helix-turn-helix domain; Region: HTH_36; pfam13730 1155766006953 Protein of unknown function (DUF968); Region: DUF968; pfam06147 1155766006954 Protein of unknown function (DUF1071); Region: DUF1071; pfam06378 1155766006955 non-specific DNA binding site [nucleotide binding]; other site 1155766006956 salt bridge; other site 1155766006957 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 1155766006958 sequence-specific DNA binding site [nucleotide binding]; other site 1155766006959 Prophage antirepressor [Transcription]; Region: COG3617 1155766006960 BRO family, N-terminal domain; Region: Bro-N; smart01040 1155766006961 Phage antirepressor protein KilAC domain; Region: ANT; pfam03374 1155766006962 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1155766006963 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1155766006964 non-specific DNA binding site [nucleotide binding]; other site 1155766006965 salt bridge; other site 1155766006966 sequence-specific DNA binding site [nucleotide binding]; other site 1155766006967 Domain of unknown function (DUF955); Region: DUF955; pfam06114 1155766006968 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 1155766006969 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1155766006970 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1155766006971 active site 1155766006972 DNA binding site [nucleotide binding] 1155766006973 Int/Topo IB signature motif; other site 1155766006974 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1155766006975 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1155766006976 ring oligomerisation interface [polypeptide binding]; other site 1155766006977 ATP/Mg binding site [chemical binding]; other site 1155766006978 stacking interactions; other site 1155766006979 hinge regions; other site 1155766006980 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1155766006981 oligomerisation interface [polypeptide binding]; other site 1155766006982 mobile loop; other site 1155766006983 roof hairpin; other site 1155766006984 CAAX protease self-immunity; Region: Abi; pfam02517 1155766006985 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 1155766006986 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1155766006987 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 1155766006988 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1155766006989 NAD binding site [chemical binding]; other site 1155766006990 substrate binding site [chemical binding]; other site 1155766006991 putative active site [active] 1155766006992 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 1155766006993 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1155766006994 YycH protein; Region: YycI; pfam09648 1155766006995 YycH protein; Region: YycH; pfam07435 1155766006996 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863 1155766006997 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 1155766006998 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1155766006999 dimerization interface [polypeptide binding]; other site 1155766007000 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1155766007001 putative active site [active] 1155766007002 heme pocket [chemical binding]; other site 1155766007003 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1155766007004 dimer interface [polypeptide binding]; other site 1155766007005 phosphorylation site [posttranslational modification] 1155766007006 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1155766007007 ATP binding site [chemical binding]; other site 1155766007008 Mg2+ binding site [ion binding]; other site 1155766007009 G-X-G motif; other site 1155766007010 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1155766007011 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1155766007012 active site 1155766007013 phosphorylation site [posttranslational modification] 1155766007014 intermolecular recognition site; other site 1155766007015 dimerization interface [polypeptide binding]; other site 1155766007016 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1155766007017 DNA binding site [nucleotide binding] 1155766007018 EDD domain protein, DegV family; Region: DegV; TIGR00762 1155766007019 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1155766007020 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 1155766007021 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1155766007022 Helix-turn-helix domain; Region: HTH_38; pfam13936 1155766007023 Integrase core domain; Region: rve; pfam00665 1155766007024 Integrase core domain; Region: rve_3; cl15866 1155766007025 Enterocin A Immunity; Region: EntA_Immun; pfam08951 1155766007026 Class II bacteriocin; Region: Bacteriocin_II; pfam01721 1155766007027 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1155766007028 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1155766007029 dimer interface [polypeptide binding]; other site 1155766007030 conserved gate region; other site 1155766007031 putative PBP binding loops; other site 1155766007032 ABC-ATPase subunit interface; other site 1155766007033 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 1155766007034 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1155766007035 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 1155766007036 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 1155766007037 Walker A/P-loop; other site 1155766007038 ATP binding site [chemical binding]; other site 1155766007039 Q-loop/lid; other site 1155766007040 ABC transporter signature motif; other site 1155766007041 Walker B; other site 1155766007042 D-loop; other site 1155766007043 H-loop/switch region; other site 1155766007044 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1155766007045 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1155766007046 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1155766007047 DNA-binding site [nucleotide binding]; DNA binding site 1155766007048 TrkA-C domain; Region: TrkA_C; pfam02080 1155766007049 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 1155766007050 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 1155766007051 G1 box; other site 1155766007052 GTP/Mg2+ binding site [chemical binding]; other site 1155766007053 Switch I region; other site 1155766007054 G2 box; other site 1155766007055 G3 box; other site 1155766007056 Switch II region; other site 1155766007057 G4 box; other site 1155766007058 G5 box; other site 1155766007059 Nucleoside recognition; Region: Gate; pfam07670 1155766007060 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 1155766007061 Nucleoside recognition; Region: Gate; pfam07670 1155766007062 FeoA domain; Region: FeoA; pfam04023 1155766007063 Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918 1155766007064 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 1155766007065 catalytic residues [active] 1155766007066 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07306 1155766007067 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 1155766007068 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1155766007069 active site 1155766007070 dimer interface [polypeptide binding]; other site 1155766007071 catalytic residues [active] 1155766007072 effector binding site; other site 1155766007073 R2 peptide binding site; other site 1155766007074 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 1155766007075 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1155766007076 dimer interface [polypeptide binding]; other site 1155766007077 putative radical transfer pathway; other site 1155766007078 diiron center [ion binding]; other site 1155766007079 tyrosyl radical; other site 1155766007080 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1155766007081 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1155766007082 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 1155766007083 MgtC family; Region: MgtC; pfam02308 1155766007084 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1155766007085 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 1155766007086 active site 1155766007087 trimer interface [polypeptide binding]; other site 1155766007088 allosteric site; other site 1155766007089 active site lid [active] 1155766007090 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1155766007091 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1155766007092 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1155766007093 Walker A/P-loop; other site 1155766007094 ATP binding site [chemical binding]; other site 1155766007095 Q-loop/lid; other site 1155766007096 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1155766007097 ABC transporter signature motif; other site 1155766007098 Walker B; other site 1155766007099 D-loop; other site 1155766007100 ABC transporter; Region: ABC_tran_2; pfam12848 1155766007101 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1155766007102 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1155766007103 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 1155766007104 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1155766007105 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1155766007106 putative substrate translocation pore; other site 1155766007107 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1155766007108 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1155766007109 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1155766007110 core dimer interface [polypeptide binding]; other site 1155766007111 peripheral dimer interface [polypeptide binding]; other site 1155766007112 L10 interface [polypeptide binding]; other site 1155766007113 L11 interface [polypeptide binding]; other site 1155766007114 putative EF-Tu interaction site [polypeptide binding]; other site 1155766007115 putative EF-G interaction site [polypeptide binding]; other site 1155766007116 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1155766007117 23S rRNA interface [nucleotide binding]; other site 1155766007118 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1155766007119 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1155766007120 mRNA/rRNA interface [nucleotide binding]; other site 1155766007121 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1155766007122 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1155766007123 23S rRNA interface [nucleotide binding]; other site 1155766007124 L7/L12 interface [polypeptide binding]; other site 1155766007125 putative thiostrepton binding site; other site 1155766007126 L25 interface [polypeptide binding]; other site 1155766007127 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 1155766007128 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1155766007129 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 1155766007130 putative L-serine binding site [chemical binding]; other site 1155766007131 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 1155766007132 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 1155766007133 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 1155766007134 L-Lactate oxidase (LOX) FMN-binding domain. LOX is a member of the family of FMN-containing alpha-hydroxyacid oxidases and catalyzes the oxidation of l-lactate using molecular oxygen to generate pyruvate and H2O2. This family occurs in both prokaryotes...; Region: LOX_like_FMN; cd04737 1155766007135 active site 1155766007136 teramer interface [polypeptide binding]; other site 1155766007137 FMN binding site [chemical binding]; other site 1155766007138 catalytic residues [active] 1155766007139 Uncharacterized protein with an alpha/beta hydrolase fold [General function prediction only]; Region: COG4814 1155766007140 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1155766007141 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1155766007142 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1155766007143 putative homodimer interface [polypeptide binding]; other site 1155766007144 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1155766007145 heterodimer interface [polypeptide binding]; other site 1155766007146 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 1155766007147 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 1155766007148 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 1155766007149 QueT transporter; Region: QueT; pfam06177 1155766007150 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 1155766007151 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1155766007152 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1155766007153 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1155766007154 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1155766007155 Walker A/P-loop; other site 1155766007156 ATP binding site [chemical binding]; other site 1155766007157 Q-loop/lid; other site 1155766007158 ABC transporter signature motif; other site 1155766007159 Walker B; other site 1155766007160 D-loop; other site 1155766007161 H-loop/switch region; other site 1155766007162 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1155766007163 Histidine kinase; Region: HisKA_3; pfam07730 1155766007164 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1155766007165 ATP binding site [chemical binding]; other site 1155766007166 Mg2+ binding site [ion binding]; other site 1155766007167 G-X-G motif; other site 1155766007168 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1155766007169 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1155766007170 active site 1155766007171 phosphorylation site [posttranslational modification] 1155766007172 intermolecular recognition site; other site 1155766007173 dimerization interface [polypeptide binding]; other site 1155766007174 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1155766007175 DNA binding residues [nucleotide binding] 1155766007176 dimerization interface [polypeptide binding]; other site 1155766007177 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 1155766007178 AAA domain; Region: AAA_30; pfam13604 1155766007179 Family description; Region: UvrD_C_2; pfam13538 1155766007180 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1155766007181 catalytic core [active] 1155766007182 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 1155766007183 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 1155766007184 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1155766007185 S-adenosylmethionine binding site [chemical binding]; other site 1155766007186 Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142 1155766007187 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 1155766007188 MgtE intracellular N domain; Region: MgtE_N; pfam03448 1155766007189 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1155766007190 Divalent cation transporter; Region: MgtE; pfam01769 1155766007191 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1155766007192 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1155766007193 active site 1155766007194 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 1155766007195 ATP-NAD kinase; Region: NAD_kinase; pfam01513 1155766007196 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1155766007197 synthetase active site [active] 1155766007198 NTP binding site [chemical binding]; other site 1155766007199 metal binding site [ion binding]; metal-binding site 1155766007200 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 1155766007201 putative active site [active] 1155766007202 putative metal binding residues [ion binding]; other site 1155766007203 signature motif; other site 1155766007204 putative triphosphate binding site [ion binding]; other site 1155766007205 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 1155766007206 catalytic residues [active] 1155766007207 potential frameshift: common BLAST hit: gi|320152794|ref|YP_004172617.1| transposase 1155766007208 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1155766007209 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1155766007210 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 1155766007211 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1155766007212 Homeodomain-like domain; Region: HTH_23; pfam13384 1155766007213 Oligoendopeptidase F [Amino acid transport and metabolism]; Region: COG1164 1155766007214 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 1155766007215 active site 1155766007216 Zn binding site [ion binding]; other site 1155766007217 Competence protein CoiA-like family; Region: CoiA; cl11541 1155766007218 Negative regulator of genetic competence (MecA); Region: MecA; pfam05389 1155766007219 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 1155766007220 ArsC family; Region: ArsC; pfam03960 1155766007221 putative catalytic residues [active] 1155766007222 thiol/disulfide switch; other site 1155766007223 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 1155766007224 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1155766007225 active site 1155766007226 motif I; other site 1155766007227 motif II; other site 1155766007228 SWIM zinc finger; Region: SWIM; pfam04434 1155766007229 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 1155766007230 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 1155766007231 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1155766007232 ATP binding site [chemical binding]; other site 1155766007233 putative Mg++ binding site [ion binding]; other site 1155766007234 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1155766007235 nucleotide binding region [chemical binding]; other site 1155766007236 ATP-binding site [chemical binding]; other site 1155766007237 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 1155766007238 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 1155766007239 Walker A/P-loop; other site 1155766007240 ATP binding site [chemical binding]; other site 1155766007241 Q-loop/lid; other site 1155766007242 ABC transporter signature motif; other site 1155766007243 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1155766007244 ABC transporter signature motif; other site 1155766007245 Walker B; other site 1155766007246 D-loop; other site 1155766007247 H-loop/switch region; other site 1155766007248 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 1155766007249 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1155766007250 active site 1155766007251 metal binding site [ion binding]; metal-binding site 1155766007252 DNA binding site [nucleotide binding] 1155766007253 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 1155766007254 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1155766007255 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1155766007256 putative acyl-acceptor binding pocket; other site 1155766007257 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 1155766007258 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1155766007259 S-adenosylmethionine binding site [chemical binding]; other site 1155766007260 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 1155766007261 GIY-YIG motif/motif A; other site 1155766007262 putative active site [active] 1155766007263 putative metal binding site [ion binding]; other site 1155766007264 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1155766007265 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 1155766007266 catalytic triad [active] 1155766007267 catalytic triad [active] 1155766007268 oxyanion hole [active] 1155766007269 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1155766007270 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1155766007271 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1155766007272 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1155766007273 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1155766007274 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1155766007275 dimer interface [polypeptide binding]; other site 1155766007276 anticodon binding site; other site 1155766007277 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1155766007278 homodimer interface [polypeptide binding]; other site 1155766007279 motif 1; other site 1155766007280 active site 1155766007281 motif 2; other site 1155766007282 GAD domain; Region: GAD; pfam02938 1155766007283 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1155766007284 motif 3; other site 1155766007285 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 1155766007286 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1155766007287 dimer interface [polypeptide binding]; other site 1155766007288 motif 1; other site 1155766007289 active site 1155766007290 motif 2; other site 1155766007291 motif 3; other site 1155766007292 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1155766007293 anticodon binding site; other site 1155766007294 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1155766007295 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1155766007296 active site 1155766007297 catalytic tetrad [active] 1155766007298 Cytochrome P450; Region: p450; cl12078 1155766007299 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1155766007300 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 1155766007301 putative active site [active] 1155766007302 dimerization interface [polypeptide binding]; other site 1155766007303 putative tRNAtyr binding site [nucleotide binding]; other site 1155766007304 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1155766007305 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1155766007306 Zn2+ binding site [ion binding]; other site 1155766007307 Mg2+ binding site [ion binding]; other site 1155766007308 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1155766007309 synthetase active site [active] 1155766007310 NTP binding site [chemical binding]; other site 1155766007311 metal binding site [ion binding]; metal-binding site 1155766007312 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1155766007313 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1155766007314 RNA methyltransferase, RsmE family; Region: TIGR00046 1155766007315 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 1155766007316 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 1155766007317 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1155766007318 S-adenosylmethionine binding site [chemical binding]; other site 1155766007319 Protein of unknown function (DUF3013); Region: DUF3013; pfam11217 1155766007320 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 1155766007321 active site 1155766007322 DNA binding site [nucleotide binding] 1155766007323 recombination factor protein RarA; Reviewed; Region: PRK13342 1155766007324 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1155766007325 Walker A motif; other site 1155766007326 ATP binding site [chemical binding]; other site 1155766007327 Walker B motif; other site 1155766007328 arginine finger; other site 1155766007329 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1155766007330 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1155766007331 Ligand Binding Site [chemical binding]; other site 1155766007332 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1155766007333 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1155766007334 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1155766007335 ABC transporter; Region: ABC_tran_2; pfam12848 1155766007336 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1155766007337 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1155766007338 propionate/acetate kinase; Provisional; Region: PRK12379 1155766007339 nucleotide binding site [chemical binding]; other site 1155766007340 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 1155766007341 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1155766007342 S-adenosylmethionine binding site [chemical binding]; other site 1155766007343 Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940 1155766007344 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 1155766007345 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1155766007346 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1155766007347 Type II/IV secretion system protein; Region: T2SE; pfam00437 1155766007348 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1155766007349 Walker A motif; other site 1155766007350 ATP binding site [chemical binding]; other site 1155766007351 Walker B motif; other site 1155766007352 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 1155766007353 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1155766007354 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 1155766007355 active site 1155766007356 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 1155766007357 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1155766007358 S-adenosylmethionine binding site [chemical binding]; other site 1155766007359 Phosphotransferase enzyme family; Region: APH; pfam01636 1155766007360 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1155766007361 active site 1155766007362 substrate binding site [chemical binding]; other site 1155766007363 ATP binding site [chemical binding]; other site 1155766007364 Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975 1155766007365 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1155766007366 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1155766007367 Walker A/P-loop; other site 1155766007368 ATP binding site [chemical binding]; other site 1155766007369 Q-loop/lid; other site 1155766007370 ABC transporter signature motif; other site 1155766007371 Walker B; other site 1155766007372 D-loop; other site 1155766007373 H-loop/switch region; other site 1155766007374 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 1155766007375 HIT family signature motif; other site 1155766007376 catalytic residue [active] 1155766007377 foldase protein PrsA; Reviewed; Region: prsA; PRK01326 1155766007378 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1155766007379 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 1155766007380 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 1155766007381 generic binding surface II; other site 1155766007382 generic binding surface I; other site 1155766007383 integrating conjugative element relaxase, PFL_4751 family; Region: ICE_TraI_Pfluor; TIGR03760 1155766007384 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1155766007385 Zn2+ binding site [ion binding]; other site 1155766007386 Mg2+ binding site [ion binding]; other site 1155766007387 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1155766007388 Walker A/P-loop; other site 1155766007389 ATP binding site [chemical binding]; other site 1155766007390 Dot/Icm secretion system protein (dot_icm_IcmQ); Region: Dot_icm_IcmQ; cl09711 1155766007391 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 1155766007392 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1155766007393 active site 1155766007394 metal binding site [ion binding]; metal-binding site 1155766007395 DNA binding site [nucleotide binding] 1155766007396 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1155766007397 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1155766007398 active site 1155766007399 motif I; other site 1155766007400 motif II; other site 1155766007401 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1155766007402 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 1155766007403 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 1155766007404 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 1155766007405 MFS/sugar transport protein; Region: MFS_2; pfam13347 1155766007406 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 1155766007407 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 1155766007408 inhibitor binding site; inhibition site 1155766007409 active site 1155766007410 putative pectinesterase; Region: PLN02432; cl01911 1155766007411 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1155766007412 Glycosyl hydrolases family 28; Region: Glyco_hydro_28; pfam00295 1155766007413 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 1155766007414 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 1155766007415 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1155766007416 Predicted integral membrane protein [Function unknown]; Region: COG5578 1155766007417 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1155766007418 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1155766007419 dimer interface [polypeptide binding]; other site 1155766007420 conserved gate region; other site 1155766007421 ABC-ATPase subunit interface; other site 1155766007422 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1155766007423 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1155766007424 dimer interface [polypeptide binding]; other site 1155766007425 conserved gate region; other site 1155766007426 putative PBP binding loops; other site 1155766007427 ABC-ATPase subunit interface; other site 1155766007428 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 1155766007429 metal binding site [ion binding]; metal-binding site 1155766007430 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1155766007431 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1155766007432 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1155766007433 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1155766007434 DNA binding site [nucleotide binding] 1155766007435 domain linker motif; other site 1155766007436 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1155766007437 dimerization interface [polypeptide binding]; other site 1155766007438 ligand binding site [chemical binding]; other site 1155766007439 altronate oxidoreductase; Provisional; Region: PRK03643 1155766007440 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1155766007441 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1155766007442 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 1155766007443 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 1155766007444 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 1155766007445 Glucuronate isomerase; Region: UxaC; pfam02614 1155766007446 Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821 1155766007447 active site 1155766007448 catalytic triad [active] 1155766007449 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1155766007450 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1155766007451 Metal-binding active site; metal-binding site 1155766007452 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1155766007453 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1155766007454 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1155766007455 Walker A/P-loop; other site 1155766007456 ATP binding site [chemical binding]; other site 1155766007457 Q-loop/lid; other site 1155766007458 ABC transporter signature motif; other site 1155766007459 Walker B; other site 1155766007460 D-loop; other site 1155766007461 H-loop/switch region; other site 1155766007462 hypothetical protein; Provisional; Region: PRK13676 1155766007463 Transglycosylase; Region: Transgly; pfam00912 1155766007464 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1155766007465 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1155766007466 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1155766007467 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1155766007468 active site 1155766007469 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1155766007470 ROK family; Region: ROK; pfam00480 1155766007471 nucleotide binding site [chemical binding]; other site 1155766007472 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 1155766007473 N-terminal catalytic domain of SPGH38, a putative alpha-mannosidase of Streptococcus pyogenes, and its prokaryotic homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_SpGH38_like; cd10814 1155766007474 active site 1155766007475 metal binding site [ion binding]; metal-binding site 1155766007476 homodimer interface [polypeptide binding]; other site 1155766007477 catalytic site [active] 1155766007478 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 1155766007479 Uncharacterized conserved protein [Function unknown]; Region: COG3538 1155766007480 Protein of unknown function (DUF1237); Region: DUF1237; pfam06824 1155766007481 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1155766007482 DNA-binding site [nucleotide binding]; DNA binding site 1155766007483 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1155766007484 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1155766007485 ligand binding site [chemical binding]; other site 1155766007486 dimerization interface [polypeptide binding]; other site 1155766007487 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 1155766007488 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 1155766007489 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 1155766007490 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1155766007491 active site 1155766007492 phosphorylation site [posttranslational modification] 1155766007493 intermolecular recognition site; other site 1155766007494 dimerization interface [polypeptide binding]; other site 1155766007495 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1155766007496 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1155766007497 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 1155766007498 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 1155766007499 dimerization interface [polypeptide binding]; other site 1155766007500 Histidine kinase; Region: His_kinase; pfam06580 1155766007501 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1155766007502 ATP binding site [chemical binding]; other site 1155766007503 Mg2+ binding site [ion binding]; other site 1155766007504 G-X-G motif; other site 1155766007505 Protein of unknown function, DUF624; Region: DUF624; cl02369 1155766007506 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1155766007507 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1155766007508 Domain of unknown function (DUF3502); Region: DUF3502; pfam12010 1155766007509 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1155766007510 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1155766007511 dimer interface [polypeptide binding]; other site 1155766007512 conserved gate region; other site 1155766007513 putative PBP binding loops; other site 1155766007514 ABC-ATPase subunit interface; other site 1155766007515 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1155766007516 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1155766007517 dimer interface [polypeptide binding]; other site 1155766007518 conserved gate region; other site 1155766007519 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1155766007520 ABC-ATPase subunit interface; other site 1155766007521 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1155766007522 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1155766007523 RNA binding surface [nucleotide binding]; other site 1155766007524 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 1155766007525 active site 1155766007526 uracil binding [chemical binding]; other site 1155766007527 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1155766007528 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 1155766007529 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1155766007530 UDP-N-acetylmuramoylalanyl-D-glutamate--L-lysine ligase; Provisional; Region: PRK14022 1155766007531 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1155766007532 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1155766007533 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1155766007534 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 1155766007535 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1155766007536 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 1155766007537 methionine cluster; other site 1155766007538 active site 1155766007539 phosphorylation site [posttranslational modification] 1155766007540 metal binding site [ion binding]; metal-binding site 1155766007541 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1155766007542 HTH domain; Region: HTH_11; pfam08279 1155766007543 Mga helix-turn-helix domain; Region: Mga; pfam05043 1155766007544 PRD domain; Region: PRD; pfam00874 1155766007545 PRD domain; Region: PRD; pfam00874 1155766007546 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1155766007547 active site 1155766007548 P-loop; other site 1155766007549 phosphorylation site [posttranslational modification] 1155766007550 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 1155766007551 active site 1155766007552 phosphorylation site [posttranslational modification] 1155766007553 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 1155766007554 active site 1155766007555 P-loop; other site 1155766007556 phosphorylation site [posttranslational modification] 1155766007557 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1155766007558 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1155766007559 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 1155766007560 Cna protein B-type domain; Region: Cna_B; pfam05738 1155766007561 Cna protein B-type domain; Region: Cna_B; pfam05738 1155766007562 Cna protein B-type domain; Region: Cna_B; pfam05738 1155766007563 Cna protein B-type domain; Region: Cna_B; pfam05738 1155766007564 Cna protein B-type domain; Region: Cna_B; pfam05738 1155766007565 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 1155766007566 catalytic residues [active] 1155766007567 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 1155766007568 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1155766007569 DNA binding residues [nucleotide binding] 1155766007570 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1155766007571 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1155766007572 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1155766007573 Walker A/P-loop; other site 1155766007574 ATP binding site [chemical binding]; other site 1155766007575 Q-loop/lid; other site 1155766007576 ABC transporter signature motif; other site 1155766007577 Walker B; other site 1155766007578 D-loop; other site 1155766007579 H-loop/switch region; other site 1155766007580 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1155766007581 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1155766007582 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1155766007583 Walker A/P-loop; other site 1155766007584 ATP binding site [chemical binding]; other site 1155766007585 Q-loop/lid; other site 1155766007586 ABC transporter signature motif; other site 1155766007587 Walker B; other site 1155766007588 D-loop; other site 1155766007589 H-loop/switch region; other site 1155766007590 BNR repeat-like domain; Region: BNR_2; pfam13088 1155766007591 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1155766007592 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1155766007593 HIGH motif; other site 1155766007594 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1155766007595 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1155766007596 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1155766007597 active site 1155766007598 KMSKS motif; other site 1155766007599 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1155766007600 tRNA binding surface [nucleotide binding]; other site 1155766007601 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 1155766007602 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1155766007603 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1155766007604 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1155766007605 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1155766007606 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1155766007607 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1155766007608 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1155766007609 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1155766007610 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1155766007611 active site 1155766007612 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 1155766007613 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1155766007614 Putative rRNA methylase; Region: rRNA_methylase; pfam06962 1155766007615 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1155766007616 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1155766007617 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1155766007618 Walker A/P-loop; other site 1155766007619 ATP binding site [chemical binding]; other site 1155766007620 Q-loop/lid; other site 1155766007621 ABC transporter signature motif; other site 1155766007622 Walker B; other site 1155766007623 D-loop; other site 1155766007624 H-loop/switch region; other site 1155766007625 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1155766007626 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1155766007627 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1155766007628 Walker A/P-loop; other site 1155766007629 ATP binding site [chemical binding]; other site 1155766007630 Q-loop/lid; other site 1155766007631 ABC transporter signature motif; other site 1155766007632 Walker B; other site 1155766007633 D-loop; other site 1155766007634 H-loop/switch region; other site 1155766007635 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1155766007636 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1155766007637 Putative esterase; Region: Esterase; pfam00756 1155766007638 S-formylglutathione hydrolase; Region: PLN02442 1155766007639 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1155766007640 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1155766007641 putative substrate translocation pore; other site 1155766007642 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1155766007643 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1155766007644 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1155766007645 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1155766007646 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1155766007647 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 1155766007648 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1155766007649 dimer interface [polypeptide binding]; other site 1155766007650 putative anticodon binding site; other site 1155766007651 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 1155766007652 motif 1; other site 1155766007653 active site 1155766007654 motif 2; other site 1155766007655 motif 3; other site 1155766007656 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 1155766007657 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1155766007658 FMN binding site [chemical binding]; other site 1155766007659 active site 1155766007660 catalytic residues [active] 1155766007661 substrate binding site [chemical binding]; other site 1155766007662 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 1155766007663 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 1155766007664 dimerization interface [polypeptide binding]; other site 1155766007665 domain crossover interface; other site 1155766007666 redox-dependent activation switch; other site 1155766007667 FtsH Extracellular; Region: FtsH_ext; pfam06480 1155766007668 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 1155766007669 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1155766007670 Walker A motif; other site 1155766007671 ATP binding site [chemical binding]; other site 1155766007672 Walker B motif; other site 1155766007673 arginine finger; other site 1155766007674 Peptidase family M41; Region: Peptidase_M41; pfam01434 1155766007675 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1155766007676 active site 1155766007677 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 1155766007678 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1155766007679 Ligand Binding Site [chemical binding]; other site 1155766007680 TilS substrate C-terminal domain; Region: TilS_C; smart00977 1155766007681 hypothetical protein; Provisional; Region: PRK08582 1155766007682 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 1155766007683 RNA binding site [nucleotide binding]; other site 1155766007684 Septum formation initiator; Region: DivIC; pfam04977 1155766007685 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 1155766007686 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1155766007687 RNA binding surface [nucleotide binding]; other site 1155766007688 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1155766007689 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 1155766007690 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 1155766007691 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 1155766007692 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1155766007693 ATP binding site [chemical binding]; other site 1155766007694 putative Mg++ binding site [ion binding]; other site 1155766007695 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1155766007696 nucleotide binding region [chemical binding]; other site 1155766007697 ATP-binding site [chemical binding]; other site 1155766007698 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 1155766007699 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1155766007700 putative active site [active] 1155766007701 catalytic residue [active] 1155766007702 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 1155766007703 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 1155766007704 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1155766007705 NAD binding site [chemical binding]; other site 1155766007706 dimer interface [polypeptide binding]; other site 1155766007707 substrate binding site [chemical binding]; other site 1155766007708 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 1155766007709 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 1155766007710 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1155766007711 hypothetical protein; Validated; Region: PRK00110 1155766007712 Predicted integral membrane protein [Function unknown]; Region: COG5652 1155766007713 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 1155766007714 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_2; cd09607 1155766007715 active site 1155766007716 Zn binding site [ion binding]; other site 1155766007717 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 1155766007718 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1155766007719 NlpC/P60 family; Region: NLPC_P60; pfam00877 1155766007720 rod shape-determining protein MreC; Provisional; Region: PRK13922 1155766007721 rod shape-determining protein MreC; Region: MreC; pfam04085 1155766007722 rod shape-determining protein MreD; Region: MreD; pfam04093 1155766007723 Thiamine pyrophosphokinase; Region: TPK; cd07995 1155766007724 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 1155766007725 active site 1155766007726 dimerization interface [polypeptide binding]; other site 1155766007727 thiamine binding site [chemical binding]; other site 1155766007728 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 1155766007729 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1155766007730 substrate binding site [chemical binding]; other site 1155766007731 hexamer interface [polypeptide binding]; other site 1155766007732 metal binding site [ion binding]; metal-binding site 1155766007733 GTPase RsgA; Reviewed; Region: PRK00098 1155766007734 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 1155766007735 RNA binding site [nucleotide binding]; other site 1155766007736 homodimer interface [polypeptide binding]; other site 1155766007737 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1155766007738 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1155766007739 GTP/Mg2+ binding site [chemical binding]; other site 1155766007740 G4 box; other site 1155766007741 G5 box; other site 1155766007742 G1 box; other site 1155766007743 Switch I region; other site 1155766007744 G2 box; other site 1155766007745 G3 box; other site 1155766007746 Switch II region; other site 1155766007747 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1155766007748 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1155766007749 active site 1155766007750 ATP binding site [chemical binding]; other site 1155766007751 substrate binding site [chemical binding]; other site 1155766007752 activation loop (A-loop); other site 1155766007753 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1155766007754 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 1155766007755 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1155766007756 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1155766007757 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1155766007758 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1155766007759 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1155766007760 active site 1155766007761 16S rRNA methyltransferase B; Provisional; Region: PRK14902 1155766007762 NusB family; Region: NusB; pfam01029 1155766007763 putative RNA binding site [nucleotide binding]; other site 1155766007764 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1155766007765 S-adenosylmethionine binding site [chemical binding]; other site 1155766007766 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1155766007767 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1155766007768 putative active site [active] 1155766007769 substrate binding site [chemical binding]; other site 1155766007770 putative cosubstrate binding site; other site 1155766007771 catalytic site [active] 1155766007772 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1155766007773 substrate binding site [chemical binding]; other site 1155766007774 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1155766007775 active site 1155766007776 catalytic residues [active] 1155766007777 metal binding site [ion binding]; metal-binding site 1155766007778 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 1155766007779 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1155766007780 ATP binding site [chemical binding]; other site 1155766007781 putative Mg++ binding site [ion binding]; other site 1155766007782 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1155766007783 nucleotide binding region [chemical binding]; other site 1155766007784 ATP-binding site [chemical binding]; other site 1155766007785 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 1155766007786 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1155766007787 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1155766007788 catalytic site [active] 1155766007789 G-X2-G-X-G-K; other site 1155766007790 hypothetical protein; Provisional; Region: PRK11820 1155766007791 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 1155766007792 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 1155766007793 Uncharacterized protein conserved in bacteria (DUF2128); Region: DUF2128; pfam09901 1155766007794 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 1155766007795 active site 1155766007796 nucleophile elbow; other site 1155766007797 Thiamine transporter protein (Thia_YuaJ); Region: Thia_YuaJ; pfam09515 1155766007798 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 1155766007799 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1155766007800 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1155766007801 active site 1155766007802 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 1155766007803 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 1155766007804 Substrate binding site; other site 1155766007805 Mg++ binding site; other site 1155766007806 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 1155766007807 active site 1155766007808 substrate binding site [chemical binding]; other site 1155766007809 CoA binding site [chemical binding]; other site 1155766007810 pur operon repressor; Provisional; Region: PRK09213 1155766007811 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 1155766007812 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1155766007813 active site 1155766007814 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1155766007815 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1155766007816 ABC-ATPase subunit interface; other site 1155766007817 dimer interface [polypeptide binding]; other site 1155766007818 putative PBP binding regions; other site 1155766007819 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1155766007820 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1155766007821 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 1155766007822 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 1155766007823 metal binding site [ion binding]; metal-binding site 1155766007824 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 1155766007825 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1155766007826 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1155766007827 Predicted integral membrane protein [Function unknown]; Region: COG0392 1155766007828 Uncharacterized conserved protein [Function unknown]; Region: COG2898 1155766007829 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 1155766007830 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1155766007831 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 1155766007832 Domain of unknown function (DUF3552); Region: DUF3552; pfam12072 1155766007833 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 1155766007834 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 1155766007835 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1155766007836 Zn2+ binding site [ion binding]; other site 1155766007837 Mg2+ binding site [ion binding]; other site 1155766007838 recombinase A; Provisional; Region: recA; PRK09354 1155766007839 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1155766007840 hexamer interface [polypeptide binding]; other site 1155766007841 Walker A motif; other site 1155766007842 ATP binding site [chemical binding]; other site 1155766007843 Walker B motif; other site 1155766007844 competence damage-inducible protein A; Provisional; Region: PRK00549 1155766007845 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 1155766007846 putative MPT binding site; other site 1155766007847 Y-family of DNA polymerases; Region: PolY; cl12025 1155766007848 Competence-damaged protein; Region: CinA; pfam02464 1155766007849 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Region: pgsA; TIGR00560 1155766007850 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 1155766007851 Helix-turn-helix domain; Region: HTH_25; pfam13413 1155766007852 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1155766007853 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1155766007854 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1155766007855 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1155766007856 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1155766007857 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 1155766007858 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 1155766007859 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1155766007860 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 1155766007861 RNA polymerase factor sigma-70; Validated; Region: PRK08295 1155766007862 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1155766007863 YacP-like NYN domain; Region: NYN_YacP; pfam05991 1155766007864 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 1155766007865 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 1155766007866 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1155766007867 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1155766007868 active site 1155766007869 metal binding site [ion binding]; metal-binding site 1155766007870 dimerization interface [polypeptide binding]; other site 1155766007871 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1155766007872 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1155766007873 active site 1155766007874 HIGH motif; other site 1155766007875 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1155766007876 KMSKS motif; other site 1155766007877 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1155766007878 tRNA binding surface [nucleotide binding]; other site 1155766007879 anticodon binding site; other site 1155766007880 serine O-acetyltransferase; Region: cysE; TIGR01172 1155766007881 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1155766007882 trimer interface [polypeptide binding]; other site 1155766007883 active site 1155766007884 substrate binding site [chemical binding]; other site 1155766007885 CoA binding site [chemical binding]; other site 1155766007886 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1155766007887 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1155766007888 HIGH motif; other site 1155766007889 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1155766007890 active site 1155766007891 KMSKS motif; other site 1155766007892 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 1155766007893 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 1155766007894 putative active site [active] 1155766007895 DNA repair protein RadA; Provisional; Region: PRK11823 1155766007896 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 1155766007897 Walker A motif/ATP binding site; other site 1155766007898 ATP binding site [chemical binding]; other site 1155766007899 Walker B motif; other site 1155766007900 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1155766007901 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1155766007902 trimer interface [polypeptide binding]; other site 1155766007903 active site 1155766007904 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1155766007905 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1155766007906 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1155766007907 Glutamate 5-kinase [Amino acid transport and metabolism]; Region: ProB; COG0263 1155766007908 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 1155766007909 nucleotide binding site [chemical binding]; other site 1155766007910 homotetrameric interface [polypeptide binding]; other site 1155766007911 putative phosphate binding site [ion binding]; other site 1155766007912 putative allosteric binding site; other site 1155766007913 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 1155766007914 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 1155766007915 putative catalytic cysteine [active] 1155766007916 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1155766007917 putative substrate translocation pore; other site 1155766007918 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1155766007919 Predicted transcriptional regulators [Transcription]; Region: COG1695 1155766007920 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1155766007921 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 1155766007922 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1155766007923 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1155766007924 ABC transporter; Region: ABC_tran_2; pfam12848 1155766007925 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1155766007926 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 1155766007927 dimer interface [polypeptide binding]; other site 1155766007928 FMN binding site [chemical binding]; other site 1155766007929 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1155766007930 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1155766007931 putative DNA binding site [nucleotide binding]; other site 1155766007932 putative Zn2+ binding site [ion binding]; other site 1155766007933 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 1155766007934 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1155766007935 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1155766007936 NAD(P) binding site [chemical binding]; other site 1155766007937 active site 1155766007938 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 1155766007939 trimer interface [polypeptide binding]; other site 1155766007940 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 1155766007941 active site 1155766007942 substrate binding site [chemical binding]; other site 1155766007943 CoA binding site [chemical binding]; other site 1155766007944 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1155766007945 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1155766007946 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1155766007947 dimerization interface [polypeptide binding]; other site 1155766007948 transcriptional antiterminator BglG; Provisional; Region: PRK09772 1155766007949 CAT RNA binding domain; Region: CAT_RBD; smart01061 1155766007950 PRD domain; Region: PRD; pfam00874 1155766007951 PRD domain; Region: PRD; pfam00874 1155766007952 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 1155766007953 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1155766007954 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1155766007955 active site turn [active] 1155766007956 phosphorylation site [posttranslational modification] 1155766007957 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 1155766007958 HPr interaction site; other site 1155766007959 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1155766007960 active site 1155766007961 phosphorylation site [posttranslational modification] 1155766007962 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1155766007963 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 1155766007964 NADP binding site [chemical binding]; other site 1155766007965 Predicted transcriptional regulator [Transcription]; Region: COG1959 1155766007966 Transcriptional regulator; Region: Rrf2; pfam02082 1155766007967 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 1155766007968 Helix-turn-helix domain; Region: HTH_18; pfam12833 1155766007969 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 1155766007970 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1155766007971 MULE transposase domain; Region: MULE; pfam10551 1155766007972 Uncharacterized conserved protein [Function unknown]; Region: COG4715 1155766007973 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1155766007974 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 1155766007975 Predicted membrane protein [Function unknown]; Region: COG4392 1155766007976 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 1155766007977 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 1155766007978 putative NAD(P) binding site [chemical binding]; other site 1155766007979 dimer interface [polypeptide binding]; other site 1155766007980 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 1155766007981 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1155766007982 FMN binding site [chemical binding]; other site 1155766007983 active site 1155766007984 catalytic residues [active] 1155766007985 substrate binding site [chemical binding]; other site 1155766007986 inner membrane transport permease; Provisional; Region: PRK15066 1155766007987 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1155766007988 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1155766007989 Walker A/P-loop; other site 1155766007990 ATP binding site [chemical binding]; other site 1155766007991 Q-loop/lid; other site 1155766007992 ABC transporter signature motif; other site 1155766007993 Walker B; other site 1155766007994 D-loop; other site 1155766007995 H-loop/switch region; other site 1155766007996 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1155766007997 Walker A/P-loop; other site 1155766007998 ATP binding site [chemical binding]; other site 1155766007999 Q-loop/lid; other site 1155766008000 ABC transporter signature motif; other site 1155766008001 Walker B; other site 1155766008002 D-loop; other site 1155766008003 H-loop/switch region; other site 1155766008004 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1155766008005 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1155766008006 dimer interface [polypeptide binding]; other site 1155766008007 phosphorylation site [posttranslational modification] 1155766008008 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1155766008009 ATP binding site [chemical binding]; other site 1155766008010 Mg2+ binding site [ion binding]; other site 1155766008011 G-X-G motif; other site 1155766008012 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1155766008013 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1155766008014 active site 1155766008015 phosphorylation site [posttranslational modification] 1155766008016 intermolecular recognition site; other site 1155766008017 dimerization interface [polypeptide binding]; other site 1155766008018 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1155766008019 DNA binding site [nucleotide binding] 1155766008020 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1155766008021 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1155766008022 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1155766008023 Walker A/P-loop; other site 1155766008024 ATP binding site [chemical binding]; other site 1155766008025 Q-loop/lid; other site 1155766008026 ABC transporter signature motif; other site 1155766008027 Walker B; other site 1155766008028 D-loop; other site 1155766008029 H-loop/switch region; other site 1155766008030 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1155766008031 MULE transposase domain; Region: MULE; pfam10551 1155766008032 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1155766008033 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1155766008034 DNA-binding site [nucleotide binding]; DNA binding site 1155766008035 UTRA domain; Region: UTRA; pfam07702 1155766008036 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 1155766008037 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1155766008038 motif II; other site 1155766008039 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 1155766008040 PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609 1155766008041 PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830 1155766008042 active site 1155766008043 phosphorylation site [posttranslational modification] 1155766008044 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 1155766008045 active pocket/dimerization site; other site 1155766008046 active site 1155766008047 phosphorylation site [posttranslational modification] 1155766008048 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 1155766008049 A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710 1155766008050 putative active site [active] 1155766008051 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1155766008052 dimer interface [polypeptide binding]; other site 1155766008053 active site 1155766008054 Transposase domain (DUF772); Region: DUF772; pfam05598 1155766008055 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1155766008056 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1155766008057 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1155766008058 MULE transposase domain; Region: MULE; pfam10551 1155766008059 Integrase core domain; Region: rve; pfam00665 1155766008060 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1155766008061 Transposase; Region: HTH_Tnp_1; pfam01527 1155766008062 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 1155766008063 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 1155766008064 Replication initiator protein A (RepA) N-terminus; Region: RepA_N; pfam06970 1155766008065 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 1155766008066 non-specific DNA binding site [nucleotide binding]; other site 1155766008067 salt bridge; other site 1155766008068 sequence-specific DNA binding site [nucleotide binding]; other site 1155766008069 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1155766008070 non-specific DNA binding site [nucleotide binding]; other site 1155766008071 salt bridge; other site 1155766008072 sequence-specific DNA binding site [nucleotide binding]; other site 1155766008073 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 1155766008074 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 1155766008075 Int/Topo IB signature motif; other site 1155766008076 Cna protein B-type domain; Region: Cna_B; pfam05738 1155766008077 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 1155766008078 Bacterial protein of unknown function (DUF961); Region: DUF961; pfam06125 1155766008079 Bacterial protein of unknown function (DUF961); Region: DUF961; pfam06125 1155766008080 RelB antitoxin; Region: RelB; cl01171 1155766008081 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1155766008082 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1155766008083 Walker A motif; other site 1155766008084 ATP binding site [chemical binding]; other site 1155766008085 Walker B motif; other site 1155766008086 arginine finger; other site 1155766008087 Zeta toxin; Region: Zeta_toxin; pfam06414 1155766008088 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185 1155766008089 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1155766008090 cofactor binding site; other site 1155766008091 DNA binding site [nucleotide binding] 1155766008092 substrate interaction site [chemical binding]; other site 1155766008093 C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145 1155766008094 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1155766008095 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1155766008096 non-specific DNA binding site [nucleotide binding]; other site 1155766008097 salt bridge; other site 1155766008098 sequence-specific DNA binding site [nucleotide binding]; other site 1155766008099 Replication initiation factor; Region: Rep_trans; pfam02486 1155766008100 Protein of unknown function (DUF3789); Region: DUF3789; pfam12664 1155766008101 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 1155766008102 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 1155766008103 putative active site [active] 1155766008104 putative NTP binding site [chemical binding]; other site 1155766008105 putative nucleic acid binding site [nucleotide binding]; other site 1155766008106 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1155766008107 active site 1155766008108 Antirestriction protein (ArdA); Region: ArdA; pfam07275 1155766008109 TcpE family; Region: TcpE; pfam12648 1155766008110 AAA-like domain; Region: AAA_10; pfam12846 1155766008111 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1155766008112 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1155766008113 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1155766008114 catalytic residue [active] 1155766008115 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1155766008116 NlpC/P60 family; Region: NLPC_P60; pfam00877 1155766008117 Conjugative transposon protein TcpC; Region: TpcC; pfam12642 1155766008118 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1155766008119 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1155766008120 putative substrate translocation pore; other site 1155766008121 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1155766008122 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 1155766008123 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1155766008124 Peptidase family M23; Region: Peptidase_M23; pfam01551 1155766008125 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 1155766008126 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1155766008127 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1155766008128 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 1155766008129 Rib/alpha-like repeat; Region: Rib; pfam08428 1155766008130 Rib/alpha-like repeat; Region: Rib; cl07159 1155766008131 Rib/alpha/Esp surface antigen repeat; Region: rib_alpha; TIGR02331 1155766008132 Rib/alpha/Esp surface antigen repeat; Region: rib_alpha; TIGR02331 1155766008133 Rib/alpha-like repeat; Region: Rib; pfam08428 1155766008134 Rib/alpha-like repeat; Region: Rib; pfam08428 1155766008135 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1155766008136 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1155766008137 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1155766008138 YSIRK-targeted surface antigen transcriptional regulator; Region: adjacent_YSIRK; TIGR04094 1155766008139 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1155766008140 Helix-turn-helix domain; Region: HTH_16; pfam12645 1155766008141 HTH-like domain; Region: HTH_21; pfam13276 1155766008142 potential frameshift: common BLAST hit: gi|352517126|ref|YP_004886443.1| putative transposase 1155766008143 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1155766008144 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1155766008145 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1155766008146 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 1155766008147 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 1155766008148 Listerrria innocua Lin0431 is similar to the N-Utilization Substance G (NusG) N terminal (NGN) insert (DII); Region: Lin0431_like; cd09911 1155766008149 trimer interface [polypeptide binding]; other site 1155766008150 Helix-turn-helix domain; Region: HTH_38; pfam13936 1155766008151 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 1155766008152 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 1155766008153 metal binding site [ion binding]; metal-binding site 1155766008154 YodA lipocalin-like domain; Region: YodA; cl01365 1155766008155 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1155766008156 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1155766008157 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 1155766008158 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 1155766008159 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 1155766008160 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 1155766008161 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1155766008162 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1155766008163 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1155766008164 Walker A/P-loop; other site 1155766008165 ATP binding site [chemical binding]; other site 1155766008166 Q-loop/lid; other site 1155766008167 ABC transporter signature motif; other site 1155766008168 Walker B; other site 1155766008169 D-loop; other site 1155766008170 H-loop/switch region; other site 1155766008171 DNA binding domain of tn916 integrase; Region: Integrase_DNA; pfam02920 1155766008172 Tn1545-related conjugative transposon integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes bacterial (gram positive) and phage integrases, including those similar to Tn1545, Tn5252, and...; Region: INT_Tn1545_C; cd01199 1155766008173 Int/Topo IB signature motif; other site 1155766008174 Excisionase from transposon Tn916; Region: Tn916-Xis; pfam09035 1155766008175 Helix-turn-helix domain; Region: HTH_16; pfam12645 1155766008176 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1155766008177 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 1155766008178 DNA binding residues [nucleotide binding] 1155766008179 D-ala-D-ala dipeptidase; Region: Peptidase_M15; pfam01427 1155766008180 D-alanine--D-lactate ligase; Provisional; Region: vanB; PRK14568 1155766008181 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1155766008182 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 1155766008183 Putative Lactate dehydrogenase and (R)-2-Hydroxyglutarate Dehydrogenase-like proteins, NAD-binding and catalytic domains; Region: HGDH_LDH_like; cd12185 1155766008184 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1155766008185 putative ligand binding site [chemical binding]; other site 1155766008186 putative NAD binding site [chemical binding]; other site 1155766008187 catalytic site [active] 1155766008188 VanW like protein; Region: VanW; pfam04294 1155766008189 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 1155766008190 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1155766008191 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1155766008192 dimerization interface [polypeptide binding]; other site 1155766008193 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1155766008194 dimer interface [polypeptide binding]; other site 1155766008195 phosphorylation site [posttranslational modification] 1155766008196 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1155766008197 ATP binding site [chemical binding]; other site 1155766008198 Mg2+ binding site [ion binding]; other site 1155766008199 G-X-G motif; other site 1155766008200 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1155766008201 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1155766008202 active site 1155766008203 phosphorylation site [posttranslational modification] 1155766008204 intermolecular recognition site; other site 1155766008205 dimerization interface [polypeptide binding]; other site 1155766008206 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1155766008207 DNA binding site [nucleotide binding] 1155766008208 Helix-turn-helix domain; Region: HTH_17; pfam12728 1155766008209 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1155766008210 non-specific DNA binding site [nucleotide binding]; other site 1155766008211 salt bridge; other site 1155766008212 sequence-specific DNA binding site [nucleotide binding]; other site 1155766008213 Bacterial mobilisation protein (MobC); Region: MobC; pfam05713 1155766008214 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 1155766008215 Cysteine-rich VLP; Region: Cys_rich_VLP; pfam14194 1155766008216 Helix-turn-helix domain; Region: HTH_16; pfam12645 1155766008217 Domain of unknown function (DUF4319); Region: DUF4319; pfam14203 1155766008218 Antirestriction protein (ArdA); Region: ArdA; cl01953 1155766008219 Domain of unknown function (DUF955); Region: DUF955; cl01076 1155766008220 YodL-like; Region: YodL; pfam14191 1155766008221 Domain of unknown function (DUF4316); Region: DUF4316; pfam14195 1155766008222 DNA topoisomerase III; Provisional; Region: PRK07726 1155766008223 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 1155766008224 active site 1155766008225 putative interdomain interaction site [polypeptide binding]; other site 1155766008226 putative metal-binding site [ion binding]; other site 1155766008227 putative nucleotide binding site [chemical binding]; other site 1155766008228 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1155766008229 domain I; other site 1155766008230 DNA binding groove [nucleotide binding] 1155766008231 phosphate binding site [ion binding]; other site 1155766008232 domain II; other site 1155766008233 domain III; other site 1155766008234 nucleotide binding site [chemical binding]; other site 1155766008235 catalytic site [active] 1155766008236 domain IV; other site 1155766008237 Bacterial SH3 domain; Region: SH3_3; pfam08239 1155766008238 Domain of unknown function (DUF4366); Region: DUF4366; pfam14283 1155766008239 Domain of unknown function (DUF4315); Region: DUF4315; pfam14193 1155766008240 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1155766008241 NlpC/P60 family; Region: NLPC_P60; pfam00877 1155766008242 AAA-like domain; Region: AAA_10; pfam12846 1155766008243 MT-A70; Region: MT-A70; pfam05063 1155766008244 Maff2 family; Region: Maff2; pfam12750 1155766008245 Type IV secretory system Conjugative DNA transfer; Region: T4SS-DNA_transf; pfam02534 1155766008246 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1155766008247 Walker A motif; other site 1155766008248 ATP binding site [chemical binding]; other site 1155766008249 Walker B motif; other site 1155766008250 Protein of unknown function (DUF3801); Region: DUF3801; pfam12687 1155766008251 Helix-turn-helix domain; Region: HTH_36; pfam13730 1155766008252 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1155766008253 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1155766008254 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1155766008255 Walker A/P-loop; other site 1155766008256 ATP binding site [chemical binding]; other site 1155766008257 Q-loop/lid; other site 1155766008258 ABC transporter signature motif; other site 1155766008259 Walker B; other site 1155766008260 D-loop; other site 1155766008261 H-loop/switch region; other site 1155766008262 conserved hypothetical integral membrane protein TIGR02185; Region: Trep_Strep 1155766008263 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1155766008264 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1155766008265 Walker A/P-loop; other site 1155766008266 ATP binding site [chemical binding]; other site 1155766008267 Q-loop/lid; other site 1155766008268 ABC transporter signature motif; other site 1155766008269 Walker B; other site 1155766008270 D-loop; other site 1155766008271 H-loop/switch region; other site 1155766008272 Second domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain2; cd03226 1155766008273 Walker A/P-loop; other site 1155766008274 ATP binding site [chemical binding]; other site 1155766008275 Q-loop/lid; other site 1155766008276 ABC transporter signature motif; other site 1155766008277 Walker B; other site 1155766008278 D-loop; other site 1155766008279 H-loop/switch region; other site 1155766008280 Cobalt transport protein; Region: CbiQ; cl00463 1155766008281 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1155766008282 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1155766008283 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 1155766008284 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 1155766008285 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 1155766008286 metal binding site [ion binding]; metal-binding site 1155766008287 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1155766008288 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1155766008289 ABC-ATPase subunit interface; other site 1155766008290 dimer interface [polypeptide binding]; other site 1155766008291 putative PBP binding regions; other site 1155766008292 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1155766008293 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1155766008294 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1155766008295 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1155766008296 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1155766008297 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1155766008298 active site 1155766008299 Int/Topo IB signature motif; other site 1155766008300 DNA binding site [nucleotide binding] 1155766008301 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 1155766008302 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1155766008303 23S rRNA interface [nucleotide binding]; other site 1155766008304 L3 interface [polypeptide binding]; other site 1155766008305 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1155766008306 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1155766008307 dimerization interface [polypeptide binding]; other site 1155766008308 DPS ferroxidase diiron center [ion binding]; other site 1155766008309 ion pore; other site 1155766008310 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 1155766008311 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 1155766008312 N- and C-terminal domain interface [polypeptide binding]; other site 1155766008313 active site 1155766008314 catalytic site [active] 1155766008315 metal binding site [ion binding]; metal-binding site 1155766008316 carbohydrate binding site [chemical binding]; other site 1155766008317 ATP binding site [chemical binding]; other site 1155766008318 hypothetical protein; Region: PHA00727 1155766008319 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 1155766008320 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 1155766008321 methionine sulfoxide reductase A; Provisional; Region: PRK14054 1155766008322 beta-phosphoglucomutase; Region: bPGM; TIGR01990 1155766008323 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1155766008324 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 1155766008325 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 1155766008326 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 1155766008327 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 1155766008328 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 1155766008329 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1155766008330 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1155766008331 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1155766008332 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1155766008333 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1155766008334 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 1155766008335 putative NAD(P) binding site [chemical binding]; other site 1155766008336 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1155766008337 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1155766008338 dimer interface [polypeptide binding]; other site 1155766008339 conserved gate region; other site 1155766008340 putative PBP binding loops; other site 1155766008341 ABC-ATPase subunit interface; other site 1155766008342 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1155766008343 dimer interface [polypeptide binding]; other site 1155766008344 conserved gate region; other site 1155766008345 putative PBP binding loops; other site 1155766008346 ABC-ATPase subunit interface; other site 1155766008347 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1155766008348 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1155766008349 Alpha amylase catalytic domain found in sucrose phosphorylase-like proteins (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase-like_1; cd11356 1155766008350 sucrose phosphorylase; Region: sucrose_gtfA; TIGR03852 1155766008351 active site 1155766008352 homodimer interface [polypeptide binding]; other site 1155766008353 catalytic site [active] 1155766008354 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706 1155766008355 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1155766008356 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1155766008357 DNA binding site [nucleotide binding] 1155766008358 domain linker motif; other site 1155766008359 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 1155766008360 putative dimerization interface [polypeptide binding]; other site 1155766008361 putative ligand binding site [chemical binding]; other site 1155766008362 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 1155766008363 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1155766008364 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 1155766008365 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1155766008366 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1155766008367 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 1155766008368 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 1155766008369 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1155766008370 DNA binding site [nucleotide binding] 1155766008371 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1155766008372 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1155766008373 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 1155766008374 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 1155766008375 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1155766008376 RPB1 interaction site [polypeptide binding]; other site 1155766008377 RPB10 interaction site [polypeptide binding]; other site 1155766008378 RPB11 interaction site [polypeptide binding]; other site 1155766008379 RPB3 interaction site [polypeptide binding]; other site 1155766008380 RPB12 interaction site [polypeptide binding]; other site 1155766008381 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 1155766008382 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1155766008383 zinc binding site [ion binding]; other site 1155766008384 putative ligand binding site [chemical binding]; other site 1155766008385 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1155766008386 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 1155766008387 TM-ABC transporter signature motif; other site 1155766008388 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 1155766008389 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1155766008390 Walker A/P-loop; other site 1155766008391 ATP binding site [chemical binding]; other site 1155766008392 Q-loop/lid; other site 1155766008393 ABC transporter signature motif; other site 1155766008394 Walker B; other site 1155766008395 D-loop; other site 1155766008396 H-loop/switch region; other site 1155766008397 Biotin operon repressor [Transcription]; Region: BirA; COG1654 1155766008398 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 1155766008399 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 1155766008400 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 1155766008401 DinB superfamily; Region: DinB_2; pfam12867 1155766008402 choice-of-anchor A domain; Region: choice_anch_A; TIGR04215 1155766008403 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 1155766008404 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1155766008405 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1155766008406 substrate binding pocket [chemical binding]; other site 1155766008407 chain length determination region; other site 1155766008408 substrate-Mg2+ binding site; other site 1155766008409 catalytic residues [active] 1155766008410 aspartate-rich region 1; other site 1155766008411 active site lid residues [active] 1155766008412 aspartate-rich region 2; other site 1155766008413 Heptaprenyl diphosphate synthase component I; Region: Hpre_diP_synt_I; pfam07456 1155766008414 Listerrria innocua Lin0431 is similar to the N-Utilization Substance G (NusG) N terminal (NGN) insert (DII); Region: Lin0431_like; cd09911 1155766008415 trimer interface [polypeptide binding]; other site 1155766008416 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1155766008417 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1155766008418 This conserved region includes the FMN-binding site of the NqrC protein as well as the NosR and NirI regulatory proteins; Region: FMN_bind; smart00900 1155766008419 FMN-binding domain; Region: FMN_bind; pfam04205 1155766008420 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 1155766008421 ApbE family; Region: ApbE; pfam02424 1155766008422 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Provisional; Region: PRK13387 1155766008423 UbiA prenyltransferase family; Region: UbiA; pfam01040 1155766008424 glutathione reductase; Validated; Region: PRK06116 1155766008425 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1155766008426 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1155766008427 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1155766008428 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1155766008429 Peptidase family U32; Region: Peptidase_U32; pfam01136 1155766008430 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1155766008431 Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an important role in NAD production by either allowing quinolinic acid (QA) , quinolinate phosphoribosyl transferase (QAPRTase), or nicotinic acid (NA), nicotinate...; Region: PRTase_typeII; cl17275 1155766008432 Peptidase family U32; Region: Peptidase_U32; pfam01136 1155766008433 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 1155766008434 Clp amino terminal domain; Region: Clp_N; pfam02861 1155766008435 Clp amino terminal domain; Region: Clp_N; pfam02861 1155766008436 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1155766008437 Walker A motif; other site 1155766008438 ATP binding site [chemical binding]; other site 1155766008439 Walker B motif; other site 1155766008440 arginine finger; other site 1155766008441 UvrB/uvrC motif; Region: UVR; pfam02151 1155766008442 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1155766008443 Walker A motif; other site 1155766008444 ATP binding site [chemical binding]; other site 1155766008445 Walker B motif; other site 1155766008446 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1155766008447 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848 1155766008448 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1155766008449 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1155766008450 active site 1155766008451 phosphorylation site [posttranslational modification] 1155766008452 intermolecular recognition site; other site 1155766008453 dimerization interface [polypeptide binding]; other site 1155766008454 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1155766008455 DNA binding site [nucleotide binding] 1155766008456 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1155766008457 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1155766008458 dimer interface [polypeptide binding]; other site 1155766008459 phosphorylation site [posttranslational modification] 1155766008460 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1155766008461 ATP binding site [chemical binding]; other site 1155766008462 Mg2+ binding site [ion binding]; other site 1155766008463 G-X-G motif; other site 1155766008464 seryl-tRNA synthetase; Provisional; Region: PRK05431 1155766008465 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1155766008466 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1155766008467 dimer interface [polypeptide binding]; other site 1155766008468 active site 1155766008469 motif 1; other site 1155766008470 motif 2; other site 1155766008471 motif 3; other site 1155766008472 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 1155766008473 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1155766008474 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 1155766008475 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1155766008476 active site 1155766008477 Protein of unknown function (DUF1129); Region: DUF1129; pfam06570 1155766008478 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 1155766008479 GTP-binding protein YchF; Reviewed; Region: PRK09601 1155766008480 YchF GTPase; Region: YchF; cd01900 1155766008481 G1 box; other site 1155766008482 GTP/Mg2+ binding site [chemical binding]; other site 1155766008483 Switch I region; other site 1155766008484 G2 box; other site 1155766008485 Switch II region; other site 1155766008486 G3 box; other site 1155766008487 G4 box; other site 1155766008488 G5 box; other site 1155766008489 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 1155766008490 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 1155766008491 ParB-like nuclease domain; Region: ParBc; pfam02195 1155766008492 KorB domain; Region: KorB; pfam08535 1155766008493 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1155766008494 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1155766008495 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1155766008496 Magnesium ion binding site [ion binding]; other site 1155766008497 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1155766008498 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 1155766008499 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 1155766008500 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 1155766008501 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 1155766008502 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 1155766008503 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 1155766008504 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 1155766008505 trmE is a tRNA modification GTPase; Region: trmE; cd04164 1155766008506 G1 box; other site 1155766008507 GTP/Mg2+ binding site [chemical binding]; other site 1155766008508 Switch I region; other site 1155766008509 G2 box; other site 1155766008510 Switch II region; other site 1155766008511 G3 box; other site 1155766008512 G4 box; other site 1155766008513 G5 box; other site 1155766008514 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 1155766008515 Putative heavy-metal-binding; Region: YbjQ_1; pfam01906 1155766008516 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 1155766008517 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 1155766008518 G-X-X-G motif; other site 1155766008519 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 1155766008520 RxxxH motif; other site 1155766008521 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 1155766008522 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 1155766008523 ribonuclease P; Reviewed; Region: rnpA; PRK00499 1155766008524 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 1155766008525 Replication protein; Region: Rep_1; cl02412 1155766008526 Plasmid recombination enzyme; Region: Mob_Pre; pfam01076 1155766008527 Protein of unknown function (DUF972); Region: DUF972; pfam06156 1155766008528 Replication initiation factor; Region: Rep_trans; pfam02486 1155766008529 Plasmid recombination enzyme; Region: Mob_Pre; pfam01076 1155766008530 Replication initiator protein A (RepA) N-terminus; Region: RepA_N; pfam06970 1155766008531 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098 1155766008532 active site 1155766008533 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 1155766008534 Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165 1155766008535 active site 1155766008536 catalytic site [active] 1155766008537 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 1155766008538 Cna protein B-type domain; Region: Cna_B; pfam05738 1155766008539 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 1155766008540 active site 1155766008541 catalytic site [active] 1155766008542 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 1155766008543 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 1155766008544 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1155766008545 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1155766008546 Walker A motif; other site 1155766008547 ATP binding site [chemical binding]; other site 1155766008548 Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505 1155766008549 TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696 1155766008550 MAEBL; Provisional; Region: PTZ00121 1155766008551 integrating conjugative element protein, PFL_4705 family; Region: conj_TIGR03752 1155766008552 AAA-like domain; Region: AAA_10; pfam12846 1155766008553 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 1155766008554 Peptidase family M23; Region: Peptidase_M23; pfam01551 1155766008555 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1155766008556 Protein of unknown function (DUF3991); Region: DUF3991; pfam13154 1155766008557 Toprim-like; Region: Toprim_2; pfam13155 1155766008558 DNA topoisomerase III; Provisional; Region: PRK07726 1155766008559 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 1155766008560 active site 1155766008561 putative interdomain interaction site [polypeptide binding]; other site 1155766008562 putative metal-binding site [ion binding]; other site 1155766008563 putative nucleotide binding site [chemical binding]; other site 1155766008564 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1155766008565 domain I; other site 1155766008566 DNA binding groove [nucleotide binding] 1155766008567 phosphate binding site [ion binding]; other site 1155766008568 domain II; other site 1155766008569 domain III; other site 1155766008570 nucleotide binding site [chemical binding]; other site 1155766008571 catalytic site [active] 1155766008572 domain IV; other site 1155766008573 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 1155766008574 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1155766008575 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 1155766008576 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1155766008577 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1155766008578 dimer interface [polypeptide binding]; other site 1155766008579 ssDNA binding site [nucleotide binding]; other site 1155766008580 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1155766008581 Transposase IS200 like; Region: Y1_Tnp; pfam01797 1155766008582 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1155766008583 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1155766008584 Probable transposase; Region: OrfB_IS605; pfam01385 1155766008585 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 1155766008586 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 1155766008587 toxin-antitoxin system, toxin component, Txe/YoeB family; Region: toxin_Txe_YoeB; TIGR02116 1155766008588 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1155766008589 Walker B; other site 1155766008590 D-loop; other site 1155766008591 H-loop/switch region; other site 1155766008592 multiple promoter invertase; Provisional; Region: mpi; PRK13413 1155766008593 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1155766008594 catalytic residues [active] 1155766008595 catalytic nucleophile [active] 1155766008596 Presynaptic Site I dimer interface [polypeptide binding]; other site 1155766008597 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1155766008598 Synaptic Flat tetramer interface [polypeptide binding]; other site 1155766008599 Synaptic Site I dimer interface [polypeptide binding]; other site 1155766008600 DNA binding site [nucleotide binding] 1155766008601 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 1155766008602 DNA-binding interface [nucleotide binding]; DNA binding site 1155766008603 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1155766008604 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1155766008605 catalytic residues [active] 1155766008606 catalytic nucleophile [active] 1155766008607 Presynaptic Site I dimer interface [polypeptide binding]; other site 1155766008608 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1155766008609 Synaptic Flat tetramer interface [polypeptide binding]; other site 1155766008610 Synaptic Site I dimer interface [polypeptide binding]; other site 1155766008611 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 1155766008612 DNA-binding interface [nucleotide binding]; DNA binding site 1155766008613 DNA polymerase IV; Reviewed; Region: PRK03103 1155766008614 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 1155766008615 active site 1155766008616 DNA binding site [nucleotide binding] 1155766008617 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 1155766008618 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1155766008619 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1155766008620 P-loop; other site 1155766008621 Magnesium ion binding site [ion binding]; other site 1155766008622 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1155766008623 Magnesium ion binding site [ion binding]; other site