-- dump date 20140619_074259 -- class Genbank::misc_feature -- table misc_feature_note -- id note 333849000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 333849000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 333849000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 333849000004 Walker A motif; other site 333849000005 ATP binding site [chemical binding]; other site 333849000006 Walker B motif; other site 333849000007 arginine finger; other site 333849000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 333849000009 DnaA box-binding interface [nucleotide binding]; other site 333849000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 333849000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 333849000012 putative DNA binding surface [nucleotide binding]; other site 333849000013 dimer interface [polypeptide binding]; other site 333849000014 beta-clamp/clamp loader binding surface; other site 333849000015 beta-clamp/translesion DNA polymerase binding surface; other site 333849000016 S4 domain protein YaaA; Region: YaaA_near_RecF; TIGR02988 333849000017 recombination protein F; Reviewed; Region: recF; PRK00064 333849000018 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 333849000019 Walker A/P-loop; other site 333849000020 ATP binding site [chemical binding]; other site 333849000021 Q-loop/lid; other site 333849000022 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 333849000023 ABC transporter signature motif; other site 333849000024 Walker B; other site 333849000025 D-loop; other site 333849000026 H-loop/switch region; other site 333849000027 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 333849000028 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 333849000029 Mg2+ binding site [ion binding]; other site 333849000030 G-X-G motif; other site 333849000031 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 333849000032 anchoring element; other site 333849000033 dimer interface [polypeptide binding]; other site 333849000034 ATP binding site [chemical binding]; other site 333849000035 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 333849000036 active site 333849000037 putative metal-binding site [ion binding]; other site 333849000038 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 333849000039 DNA gyrase subunit A; Validated; Region: PRK05560 333849000040 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 333849000041 CAP-like domain; other site 333849000042 active site 333849000043 primary dimer interface [polypeptide binding]; other site 333849000044 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 333849000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 333849000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 333849000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 333849000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 333849000049 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 333849000050 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 333849000051 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 333849000052 dimer interface [polypeptide binding]; other site 333849000053 ssDNA binding site [nucleotide binding]; other site 333849000054 tetramer (dimer of dimers) interface [polypeptide binding]; other site 333849000055 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 333849000056 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 333849000057 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 333849000058 DHH family; Region: DHH; pfam01368 333849000059 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 333849000060 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 333849000061 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 333849000062 replicative DNA helicase; Provisional; Region: PRK05748 333849000063 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 333849000064 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 333849000065 Walker A motif; other site 333849000066 ATP binding site [chemical binding]; other site 333849000067 Walker B motif; other site 333849000068 DNA binding loops [nucleotide binding] 333849000069 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 333849000070 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 333849000071 GDP-binding site [chemical binding]; other site 333849000072 ACT binding site; other site 333849000073 IMP binding site; other site 333849000074 EDD domain protein, DegV family; Region: DegV; TIGR00762 333849000075 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 333849000076 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 333849000077 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 333849000078 Walker A/P-loop; other site 333849000079 ATP binding site [chemical binding]; other site 333849000080 Q-loop/lid; other site 333849000081 ABC transporter signature motif; other site 333849000082 Walker B; other site 333849000083 D-loop; other site 333849000084 H-loop/switch region; other site 333849000085 ABC transporter; Region: ABC_tran_2; pfam12848 333849000086 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 333849000087 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 333849000088 pyruvate oxidase; Region: pyruv_oxi_spxB; TIGR02720 333849000089 PYR/PP interface [polypeptide binding]; other site 333849000090 dimer interface [polypeptide binding]; other site 333849000091 tetramer interface [polypeptide binding]; other site 333849000092 TPP binding site [chemical binding]; other site 333849000093 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 333849000094 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 333849000095 TPP-binding site [chemical binding]; other site 333849000096 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 333849000097 ZIP Zinc transporter; Region: Zip; pfam02535 333849000098 Protein of unknown function (DUF1211); Region: DUF1211; cl01421 333849000099 VanZ like family; Region: VanZ; pfam04892 333849000100 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 333849000101 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 333849000102 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 333849000103 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 333849000104 motif II; other site 333849000105 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 333849000106 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 333849000107 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 333849000108 6-phospho-beta-galactosidase; Provisional; Region: PRK13511 333849000109 beta-galactosidase; Region: BGL; TIGR03356 333849000110 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 333849000111 methionine cluster; other site 333849000112 active site 333849000113 phosphorylation site [posttranslational modification] 333849000114 metal binding site [ion binding]; metal-binding site 333849000115 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; cl17295 333849000116 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 333849000117 PTS_IIB_lactose: subunit IIB of enzyme II (EII) of the lactose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS) found in Firmicutes as well as Actinobacteria. In this system, EII is a lactose-specific permease with two...; Region: PTS_IIB_lactose; cd05565 333849000118 active site 333849000119 P-loop; other site 333849000120 phosphorylation site [posttranslational modification] 333849000121 Glycosyl hydrolase family 53; Region: Glyco_hydro_53; cl06672 333849000122 GMP synthase; Reviewed; Region: guaA; PRK00074 333849000123 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 333849000124 AMP/PPi binding site [chemical binding]; other site 333849000125 candidate oxyanion hole; other site 333849000126 catalytic triad [active] 333849000127 potential glutamine specificity residues [chemical binding]; other site 333849000128 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 333849000129 ATP Binding subdomain [chemical binding]; other site 333849000130 Dimerization subdomain; other site 333849000131 pantothenate kinase; Provisional; Region: PRK05439 333849000132 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 333849000133 ATP-binding site [chemical binding]; other site 333849000134 CoA-binding site [chemical binding]; other site 333849000135 Mg2+-binding site [ion binding]; other site 333849000136 Methyltransferase domain; Region: Methyltransf_31; pfam13847 333849000137 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 333849000138 S-adenosylmethionine binding site [chemical binding]; other site 333849000139 Transcriptional regulators [Transcription]; Region: PurR; COG1609 333849000140 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 333849000141 DNA binding site [nucleotide binding] 333849000142 domain linker motif; other site 333849000143 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 333849000144 dimerization interface [polypeptide binding]; other site 333849000145 ligand binding site [chemical binding]; other site 333849000146 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 333849000147 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 333849000148 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 333849000149 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 333849000150 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 333849000151 intersubunit interface [polypeptide binding]; other site 333849000152 active site 333849000153 catalytic residue [active] 333849000154 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 333849000155 active site 333849000156 catalytic motif [active] 333849000157 Zn binding site [ion binding]; other site 333849000158 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 333849000159 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 333849000160 ligand binding site [chemical binding]; other site 333849000161 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 333849000162 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 333849000163 Walker A/P-loop; other site 333849000164 ATP binding site [chemical binding]; other site 333849000165 Q-loop/lid; other site 333849000166 ABC transporter signature motif; other site 333849000167 Walker B; other site 333849000168 D-loop; other site 333849000169 H-loop/switch region; other site 333849000170 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 333849000171 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 333849000172 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 333849000173 TM-ABC transporter signature motif; other site 333849000174 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 333849000175 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 333849000176 TM-ABC transporter signature motif; other site 333849000177 phosphopentomutase; Provisional; Region: PRK05362 333849000178 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 333849000179 purine nucleoside phosphorylase; Provisional; Region: PRK08202 333849000180 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 333849000181 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 333849000182 potential frameshift: common BLAST hit: gi|383327407|ref|YP_005353291.1| phosphoglycerate mutase 333849000183 Phosphoglycerate mutase family; Region: PGAM; smart00855 333849000184 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 333849000185 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 333849000186 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 333849000187 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 333849000188 catalytic residues [active] 333849000189 catalytic nucleophile [active] 333849000190 Presynaptic Site I dimer interface [polypeptide binding]; other site 333849000191 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 333849000192 Synaptic Flat tetramer interface [polypeptide binding]; other site 333849000193 Synaptic Site I dimer interface [polypeptide binding]; other site 333849000194 DNA binding site [nucleotide binding] 333849000195 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 333849000196 tetramer (dimer of dimers) interface [polypeptide binding]; other site 333849000197 active site 333849000198 dimer interface [polypeptide binding]; other site 333849000199 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 333849000200 S17 interaction site [polypeptide binding]; other site 333849000201 S8 interaction site; other site 333849000202 16S rRNA interaction site [nucleotide binding]; other site 333849000203 streptomycin interaction site [chemical binding]; other site 333849000204 23S rRNA interaction site [nucleotide binding]; other site 333849000205 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 333849000206 30S ribosomal protein S7; Validated; Region: PRK05302 333849000207 elongation factor G; Reviewed; Region: PRK00007 333849000208 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 333849000209 G1 box; other site 333849000210 putative GEF interaction site [polypeptide binding]; other site 333849000211 GTP/Mg2+ binding site [chemical binding]; other site 333849000212 Switch I region; other site 333849000213 G2 box; other site 333849000214 G3 box; other site 333849000215 Switch II region; other site 333849000216 G4 box; other site 333849000217 G5 box; other site 333849000218 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 333849000219 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 333849000220 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 333849000221 elongation factor Tu; Reviewed; Region: PRK00049 333849000222 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 333849000223 G1 box; other site 333849000224 GEF interaction site [polypeptide binding]; other site 333849000225 GTP/Mg2+ binding site [chemical binding]; other site 333849000226 Switch I region; other site 333849000227 G2 box; other site 333849000228 G3 box; other site 333849000229 Switch II region; other site 333849000230 G4 box; other site 333849000231 G5 box; other site 333849000232 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 333849000233 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 333849000234 Antibiotic Binding Site [chemical binding]; other site 333849000235 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 333849000236 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 333849000237 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 333849000238 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 333849000239 potential frameshift: common BLAST hit: gi|383327418|ref|YP_005353302.1| 50S ribosomal protein L2 333849000240 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 333849000241 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 333849000242 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 333849000243 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 333849000244 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 333849000245 putative translocon binding site; other site 333849000246 protein-rRNA interface [nucleotide binding]; other site 333849000247 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 333849000248 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 333849000249 G-X-X-G motif; other site 333849000250 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 333849000251 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 333849000252 23S rRNA interface [nucleotide binding]; other site 333849000253 5S rRNA interface [nucleotide binding]; other site 333849000254 putative antibiotic binding site [chemical binding]; other site 333849000255 L25 interface [polypeptide binding]; other site 333849000256 L27 interface [polypeptide binding]; other site 333849000257 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 333849000258 23S rRNA interface [nucleotide binding]; other site 333849000259 putative translocon interaction site; other site 333849000260 signal recognition particle (SRP54) interaction site; other site 333849000261 L23 interface [polypeptide binding]; other site 333849000262 trigger factor interaction site; other site 333849000263 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 333849000264 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 333849000265 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 333849000266 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 333849000267 RNA binding site [nucleotide binding]; other site 333849000268 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 333849000269 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 333849000270 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 333849000271 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 333849000272 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 333849000273 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 333849000274 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 333849000275 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 333849000276 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 333849000277 5S rRNA interface [nucleotide binding]; other site 333849000278 L27 interface [polypeptide binding]; other site 333849000279 23S rRNA interface [nucleotide binding]; other site 333849000280 L5 interface [polypeptide binding]; other site 333849000281 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 333849000282 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 333849000283 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 333849000284 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 333849000285 23S rRNA binding site [nucleotide binding]; other site 333849000286 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 333849000287 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 333849000288 SecY translocase; Region: SecY; pfam00344 333849000289 adenylate kinase; Reviewed; Region: adk; PRK00279 333849000290 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 333849000291 AMP-binding site [chemical binding]; other site 333849000292 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 333849000293 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 333849000294 rRNA binding site [nucleotide binding]; other site 333849000295 predicted 30S ribosome binding site; other site 333849000296 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 333849000297 30S ribosomal protein S13; Region: bact_S13; TIGR03631 333849000298 30S ribosomal protein S11; Validated; Region: PRK05309 333849000299 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 333849000300 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 333849000301 alphaNTD homodimer interface [polypeptide binding]; other site 333849000302 alphaNTD - beta interaction site [polypeptide binding]; other site 333849000303 alphaNTD - beta' interaction site [polypeptide binding]; other site 333849000304 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 333849000305 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 333849000306 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635 333849000307 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 333849000308 Walker A/P-loop; other site 333849000309 ATP binding site [chemical binding]; other site 333849000310 Q-loop/lid; other site 333849000311 ABC transporter signature motif; other site 333849000312 Walker B; other site 333849000313 D-loop; other site 333849000314 H-loop/switch region; other site 333849000315 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13634 333849000316 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 333849000317 Walker A/P-loop; other site 333849000318 ATP binding site [chemical binding]; other site 333849000319 Q-loop/lid; other site 333849000320 ABC transporter signature motif; other site 333849000321 Walker B; other site 333849000322 D-loop; other site 333849000323 H-loop/switch region; other site 333849000324 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 333849000325 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 333849000326 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 333849000327 dimerization interface 3.5A [polypeptide binding]; other site 333849000328 active site 333849000329 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 333849000330 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 333849000331 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 333849000332 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 333849000333 DAK2 domain; Region: Dak2; pfam02734 333849000334 ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020 333849000335 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 333849000336 Y-family of DNA polymerases; Region: PolY; cl12025 333849000337 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 333849000338 generic binding surface II; other site 333849000339 ssDNA binding site; other site 333849000340 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 333849000341 ATP binding site [chemical binding]; other site 333849000342 putative Mg++ binding site [ion binding]; other site 333849000343 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 333849000344 nucleotide binding region [chemical binding]; other site 333849000345 ATP-binding site [chemical binding]; other site 333849000346 putative phosphate acyltransferase; Provisional; Region: PRK05331 333849000347 acyl carrier protein; Provisional; Region: acpP; PRK00982 333849000348 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 333849000349 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 333849000350 Walker A/P-loop; other site 333849000351 ATP binding site [chemical binding]; other site 333849000352 Q-loop/lid; other site 333849000353 ABC transporter signature motif; other site 333849000354 Walker B; other site 333849000355 D-loop; other site 333849000356 H-loop/switch region; other site 333849000357 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 333849000358 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 333849000359 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 333849000360 Walker A/P-loop; other site 333849000361 ATP binding site [chemical binding]; other site 333849000362 Q-loop/lid; other site 333849000363 ABC transporter signature motif; other site 333849000364 Walker B; other site 333849000365 D-loop; other site 333849000366 H-loop/switch region; other site 333849000367 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 333849000368 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 333849000369 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 333849000370 dimer interface [polypeptide binding]; other site 333849000371 conserved gate region; other site 333849000372 putative PBP binding loops; other site 333849000373 ABC-ATPase subunit interface; other site 333849000374 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 333849000375 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 333849000376 putative PBP binding loops; other site 333849000377 dimer interface [polypeptide binding]; other site 333849000378 ABC-ATPase subunit interface; other site 333849000379 The substrate binding component of an ABC-type lactococcal OppA-like transport system contains; Region: PBP2_Lactococcal_OppA_like; cd08510 333849000380 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 333849000381 peptide binding site [polypeptide binding]; other site 333849000382 ribonuclease III; Reviewed; Region: rnc; PRK00102 333849000383 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 333849000384 dimerization interface [polypeptide binding]; other site 333849000385 active site 333849000386 metal binding site [ion binding]; metal-binding site 333849000387 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 333849000388 dsRNA binding site [nucleotide binding]; other site 333849000389 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 333849000390 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 333849000391 Walker A/P-loop; other site 333849000392 ATP binding site [chemical binding]; other site 333849000393 Q-loop/lid; other site 333849000394 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 333849000395 Protein of unknown function (DUF2968); Region: DUF2968; pfam11180 333849000396 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 333849000397 ABC transporter signature motif; other site 333849000398 Walker B; other site 333849000399 D-loop; other site 333849000400 H-loop/switch region; other site 333849000401 sugar phosphate phosphatase; Provisional; Region: PRK10513 333849000402 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 333849000403 active site 333849000404 motif I; other site 333849000405 motif II; other site 333849000406 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 333849000407 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 333849000408 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 333849000409 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 333849000410 P loop; other site 333849000411 GTP binding site [chemical binding]; other site 333849000412 Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352 333849000413 bifunctional glutamate--cysteine ligase/glutathione synthetase; Provisional; Region: PRK02471 333849000414 ATP-grasp domain; Region: ATP-grasp_4; cl17255 333849000415 Protein of unknown function (DUF1694); Region: DUF1694; pfam07997 333849000416 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 333849000417 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 333849000418 ABC-ATPase subunit interface; other site 333849000419 dimer interface [polypeptide binding]; other site 333849000420 putative PBP binding regions; other site 333849000421 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 333849000422 ABC-ATPase subunit interface; other site 333849000423 dimer interface [polypeptide binding]; other site 333849000424 putative PBP binding regions; other site 333849000425 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 333849000426 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 333849000427 Walker A/P-loop; other site 333849000428 ATP binding site [chemical binding]; other site 333849000429 Q-loop/lid; other site 333849000430 ABC transporter signature motif; other site 333849000431 Walker B; other site 333849000432 D-loop; other site 333849000433 H-loop/switch region; other site 333849000434 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 333849000435 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 333849000436 putative ligand binding residues [chemical binding]; other site 333849000437 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4918 333849000438 putative phosphoesterase; Region: acc_ester; TIGR03729 333849000439 WxL domain surface cell wall-binding; Region: WxL; pfam13731 333849000440 legume lectins; Region: lectin_L-type; cd01951 333849000441 homotetramer interaction site [polypeptide binding]; other site 333849000442 homodimer interaction site [polypeptide binding]; other site 333849000443 carbohydrate binding site [chemical binding]; other site 333849000444 metal binding site [ion binding]; metal-binding site 333849000445 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 333849000446 WxL domain surface cell wall-binding; Region: WxL; pfam13731 333849000447 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 333849000448 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 333849000449 Mga helix-turn-helix domain; Region: Mga; pfam05043 333849000450 Transposase, Mutator family; Region: Transposase_mut; pfam00872 333849000451 MULE transposase domain; Region: MULE; pfam10551 333849000452 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 333849000453 Helix-turn-helix domain; Region: HTH_38; pfam13936 333849000454 Integrase core domain; Region: rve; pfam00665 333849000455 Integrase core domain; Region: rve_3; cl15866 333849000456 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 333849000457 amphipathic channel; other site 333849000458 Asn-Pro-Ala signature motifs; other site 333849000459 LrgA family; Region: LrgA; pfam03788 333849000460 LrgB-like family; Region: LrgB; pfam04172 333849000461 Mga helix-turn-helix domain; Region: Mga; pfam05043 333849000462 Protein of unknown function (DUF2829); Region: DUF2829; pfam11195 333849000463 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK06550 333849000464 classical (c) SDRs; Region: SDR_c; cd05233 333849000465 NAD(P) binding site [chemical binding]; other site 333849000466 active site 333849000467 QueT transporter; Region: QueT; pfam06177 333849000468 BioY family; Region: BioY; pfam02632 333849000469 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 333849000470 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 333849000471 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 333849000472 RNA binding surface [nucleotide binding]; other site 333849000473 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927 333849000474 A new structural DNA glycosylase containing HEAT-like repeats; Region: AlkD_like_1; cd07064 333849000475 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 333849000476 active site 333849000477 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 333849000478 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 333849000479 active site 333849000480 motif I; other site 333849000481 motif II; other site 333849000482 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 333849000483 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 333849000484 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 333849000485 putative active site [active] 333849000486 metal binding site [ion binding]; metal-binding site 333849000487 homodimer binding site [polypeptide binding]; other site 333849000488 Protein of unknown function (DUF964); Region: DUF964; cl01483 333849000489 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 333849000490 MutS domain I; Region: MutS_I; pfam01624 333849000491 MutS domain II; Region: MutS_II; pfam05188 333849000492 MutS domain III; Region: MutS_III; pfam05192 333849000493 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 333849000494 Walker A/P-loop; other site 333849000495 ATP binding site [chemical binding]; other site 333849000496 Q-loop/lid; other site 333849000497 ABC transporter signature motif; other site 333849000498 Walker B; other site 333849000499 D-loop; other site 333849000500 H-loop/switch region; other site 333849000501 DNA mismatch repair enzyme (predicted ATPase) [DNA replication, recombination, and repair]; Region: MutL; COG0323 333849000502 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 333849000503 ATP binding site [chemical binding]; other site 333849000504 Mg2+ binding site [ion binding]; other site 333849000505 G-X-G motif; other site 333849000506 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 333849000507 ATP binding site [chemical binding]; other site 333849000508 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 333849000509 Maf-like protein; Region: Maf; pfam02545 333849000510 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 333849000511 active site 333849000512 dimer interface [polypeptide binding]; other site 333849000513 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 333849000514 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 333849000515 active site turn [active] 333849000516 phosphorylation site [posttranslational modification] 333849000517 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 333849000518 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 333849000519 HPr interaction site; other site 333849000520 glycerol kinase (GK) interaction site [polypeptide binding]; other site 333849000521 active site 333849000522 phosphorylation site [posttranslational modification] 333849000523 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 333849000524 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 333849000525 DNA-binding site [nucleotide binding]; DNA binding site 333849000526 UTRA domain; Region: UTRA; pfam07702 333849000527 methionine sulfoxide reductase B; Provisional; Region: PRK00222 333849000528 SelR domain; Region: SelR; pfam01641 333849000529 potential frameshift: common BLAST hit: gi|383327502|ref|YP_005353386.1| Holliday junction DNA helicase RuvA 333849000530 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 333849000531 RuvA N terminal domain; Region: RuvA_N; pfam01330 333849000532 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 333849000533 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 333849000534 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 333849000535 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 333849000536 Walker A motif; other site 333849000537 ATP binding site [chemical binding]; other site 333849000538 Walker B motif; other site 333849000539 arginine finger; other site 333849000540 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 333849000541 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 333849000542 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 333849000543 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 333849000544 Low molecular weight phosphatase family; Region: LMWPc; cd00115 333849000545 active site 333849000546 Transposase, Mutator family; Region: Transposase_mut; pfam00872 333849000547 MULE transposase domain; Region: MULE; pfam10551 333849000548 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 333849000549 Protein of unknown function (DUF1211); Region: DUF1211; cl01421 333849000550 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 333849000551 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 333849000552 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 333849000553 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 333849000554 Walker A/P-loop; other site 333849000555 ATP binding site [chemical binding]; other site 333849000556 Q-loop/lid; other site 333849000557 ABC transporter signature motif; other site 333849000558 Walker B; other site 333849000559 D-loop; other site 333849000560 H-loop/switch region; other site 333849000561 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 333849000562 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 333849000563 substrate binding pocket [chemical binding]; other site 333849000564 membrane-bound complex binding site; other site 333849000565 hinge residues; other site 333849000566 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 333849000567 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 333849000568 dimer interface [polypeptide binding]; other site 333849000569 conserved gate region; other site 333849000570 putative PBP binding loops; other site 333849000571 ABC-ATPase subunit interface; other site 333849000572 NAD-dependent deacetylase; Provisional; Region: PRK00481 333849000573 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 333849000574 maltose O-acetyltransferase; Provisional; Region: PRK10092 333849000575 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 333849000576 active site 333849000577 substrate binding site [chemical binding]; other site 333849000578 trimer interface [polypeptide binding]; other site 333849000579 CoA binding site [chemical binding]; other site 333849000580 hypothetical protein; Provisional; Region: PRK07248 333849000581 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 333849000582 HTH domain; Region: HTH_11; pfam08279 333849000583 3H domain; Region: 3H; pfam02829 333849000584 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 333849000585 active site 333849000586 catalytic residues [active] 333849000587 metal binding site [ion binding]; metal-binding site 333849000588 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 333849000589 16S/18S rRNA binding site [nucleotide binding]; other site 333849000590 S13e-L30e interaction site [polypeptide binding]; other site 333849000591 25S rRNA binding site [nucleotide binding]; other site 333849000592 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 333849000593 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 333849000594 RNase E interface [polypeptide binding]; other site 333849000595 trimer interface [polypeptide binding]; other site 333849000596 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 333849000597 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 333849000598 RNase E interface [polypeptide binding]; other site 333849000599 trimer interface [polypeptide binding]; other site 333849000600 active site 333849000601 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 333849000602 putative nucleic acid binding region [nucleotide binding]; other site 333849000603 G-X-X-G motif; other site 333849000604 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 333849000605 RNA binding site [nucleotide binding]; other site 333849000606 domain interface; other site 333849000607 K+ potassium transporter; Region: K_trans; cl15781 333849000608 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 333849000609 Domain of unknown function DUF21; Region: DUF21; pfam01595 333849000610 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 333849000611 Transporter associated domain; Region: CorC_HlyC; smart01091 333849000612 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 333849000613 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 333849000614 Staphylococcal protein of unknown function (DUF960); Region: DUF960; pfam06124 333849000615 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 333849000616 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 333849000617 5S rRNA interface [nucleotide binding]; other site 333849000618 CTC domain interface [polypeptide binding]; other site 333849000619 L16 interface [polypeptide binding]; other site 333849000620 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 333849000621 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 333849000622 active site 333849000623 uracil binding [chemical binding]; other site 333849000624 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 333849000625 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 333849000626 motif II; other site 333849000627 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 333849000628 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 333849000629 Sugar specificity; other site 333849000630 Pyrimidine base specificity; other site 333849000631 ATP-binding site [chemical binding]; other site 333849000632 potential frameshift: common BLAST hit: gi|383327530|ref|YP_005353414.1| ISEnfa3, transposase 333849000633 Integrase core domain; Region: rve; pfam00665 333849000634 Integrase core domain; Region: rve_2; pfam13333 333849000635 HTH-like domain; Region: HTH_21; pfam13276 333849000636 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 333849000637 Helix-turn-helix domain; Region: HTH_28; pfam13518 333849000638 Helix-turn-helix domain; Region: HTH_28; pfam13518 333849000639 Winged helix-turn helix; Region: HTH_29; pfam13551 333849000640 Homeodomain-like domain; Region: HTH_32; pfam13565 333849000641 Uncharacterized conserved protein [Function unknown]; Region: COG0398 333849000642 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 333849000643 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 333849000644 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 333849000645 hypothetical protein; Validated; Region: PRK00124 333849000646 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 333849000647 ABC1 family; Region: ABC1; cl17513 333849000648 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 333849000649 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 333849000650 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 333849000651 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 333849000652 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 333849000653 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 333849000654 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 333849000655 DEAD-like helicases superfamily; Region: DEXDc; smart00487 333849000656 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 333849000657 ATP binding site [chemical binding]; other site 333849000658 Mg++ binding site [ion binding]; other site 333849000659 motif III; other site 333849000660 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 333849000661 nucleotide binding region [chemical binding]; other site 333849000662 ATP-binding site [chemical binding]; other site 333849000663 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 333849000664 alanine racemase; Reviewed; Region: alr; PRK00053 333849000665 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 333849000666 active site 333849000667 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 333849000668 dimer interface [polypeptide binding]; other site 333849000669 substrate binding site [chemical binding]; other site 333849000670 catalytic residues [active] 333849000671 PemK-like protein; Region: PemK; pfam02452 333849000672 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 333849000673 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 333849000674 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 333849000675 putative NAD(P) binding site [chemical binding]; other site 333849000676 Predicted membrane protein [Function unknown]; Region: COG1511 333849000677 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 333849000678 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 333849000679 Amino acid permease; Region: AA_permease_2; pfam13520 333849000680 Predicted transcriptional regulator [Transcription]; Region: COG4189 333849000681 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 333849000682 Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389 333849000683 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 333849000684 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 333849000685 dimer interface [polypeptide binding]; other site 333849000686 conserved gate region; other site 333849000687 putative PBP binding loops; other site 333849000688 ABC-ATPase subunit interface; other site 333849000689 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 333849000690 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 333849000691 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 333849000692 dimer interface [polypeptide binding]; other site 333849000693 conserved gate region; other site 333849000694 putative PBP binding loops; other site 333849000695 ABC-ATPase subunit interface; other site 333849000696 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 333849000697 glycine betaine/L-proline transport ATP binding subunit; Region: proV; TIGR01186 333849000698 Walker A/P-loop; other site 333849000699 ATP binding site [chemical binding]; other site 333849000700 Q-loop/lid; other site 333849000701 ABC transporter signature motif; other site 333849000702 Walker B; other site 333849000703 D-loop; other site 333849000704 H-loop/switch region; other site 333849000705 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 333849000706 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 333849000707 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 333849000708 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 333849000709 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 333849000710 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 333849000711 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 333849000712 Soluble P-type ATPase [General function prediction only]; Region: COG4087 333849000713 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 333849000714 Protein of unknown function (DUF975); Region: DUF975; cl10504 333849000715 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 333849000716 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 333849000717 Preprotein translocase subunit; Region: YajC; cl00806 333849000718 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 333849000719 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 333849000720 putative catalytic cysteine [active] 333849000721 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 333849000722 putative active site [active] 333849000723 metal binding site [ion binding]; metal-binding site 333849000724 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 333849000725 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 333849000726 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 333849000727 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 333849000728 DctM-like transporters; Region: DctM; pfam06808 333849000729 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 333849000730 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 333849000731 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 333849000732 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 333849000733 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 333849000734 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 333849000735 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 333849000736 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 333849000737 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 333849000738 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 333849000739 N- and C-terminal domain interface [polypeptide binding]; other site 333849000740 rhamnulokinase; Region: rhamnulo_kin; TIGR02627 333849000741 active site 333849000742 putative catalytic site [active] 333849000743 metal binding site [ion binding]; metal-binding site 333849000744 ATP binding site [chemical binding]; other site 333849000745 carbohydrate binding site [chemical binding]; other site 333849000746 L-rhamnose isomerase; Provisional; Region: PRK01076 333849000747 Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900 333849000748 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 333849000749 intersubunit interface [polypeptide binding]; other site 333849000750 active site 333849000751 Zn2+ binding site [ion binding]; other site 333849000752 Domain of unknown function (DUF718); Region: DUF718; cl01281 333849000753 L-1,2-propanediol oxidoreductase; Provisional; Region: PRK10624 333849000754 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 333849000755 dimer interface [polypeptide binding]; other site 333849000756 active site 333849000757 metal binding site [ion binding]; metal-binding site 333849000758 Transcriptional regulator [Transcription]; Region: IclR; COG1414 333849000759 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 333849000760 Bacterial transcriptional regulator; Region: IclR; pfam01614 333849000761 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 333849000762 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 333849000763 active site 333849000764 intersubunit interface [polypeptide binding]; other site 333849000765 catalytic residue [active] 333849000766 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 333849000767 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 333849000768 substrate binding site [chemical binding]; other site 333849000769 ATP binding site [chemical binding]; other site 333849000770 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 333849000771 gluconate 5-dehydrogenase; Provisional; Region: PRK07097 333849000772 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 333849000773 NADP binding site [chemical binding]; other site 333849000774 homodimer interface [polypeptide binding]; other site 333849000775 active site 333849000776 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 333849000777 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 333849000778 homotetramer interface [polypeptide binding]; other site 333849000779 FMN binding site [chemical binding]; other site 333849000780 homodimer contacts [polypeptide binding]; other site 333849000781 putative active site [active] 333849000782 putative substrate binding site [chemical binding]; other site 333849000783 phosphomevalonate kinase, ERG8-type, Gram-positive branch; Region: Pmev_kin_Gr_pos; TIGR01220 333849000784 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 333849000785 diphosphomevalonate decarboxylase; Region: mevDPdecarb; TIGR01240 333849000786 diphosphomevalonate decarboxylase; Region: PLN02407 333849000787 mevalonate kinase; Region: mevalon_kin; TIGR00549 333849000788 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 333849000789 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 333849000790 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 333849000791 Substrate-binding site [chemical binding]; other site 333849000792 Substrate specificity [chemical binding]; other site 333849000793 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 333849000794 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 333849000795 Cl binding site [ion binding]; other site 333849000796 oligomer interface [polypeptide binding]; other site 333849000797 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 333849000798 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 333849000799 ribosomal protein L20 leader; HMPREF0351_nc10002 333849000800 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 333849000801 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 333849000802 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 333849000803 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 333849000804 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 333849000805 23S rRNA binding site [nucleotide binding]; other site 333849000806 L21 binding site [polypeptide binding]; other site 333849000807 L13 binding site [polypeptide binding]; other site 333849000808 Citrate transporter; Region: CitMHS; pfam03600 333849000809 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 333849000810 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 333849000811 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 333849000812 Transcriptional regulators [Transcription]; Region: GntR; COG1802 333849000813 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 333849000814 DNA-binding site [nucleotide binding]; DNA binding site 333849000815 FCD domain; Region: FCD; pfam07729 333849000816 NosL; Region: NosL; cl01769 333849000817 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 333849000818 active site 333849000819 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 333849000820 putative substrate binding site [chemical binding]; other site 333849000821 putative ATP binding site [chemical binding]; other site 333849000822 dipeptidase PepV; Reviewed; Region: PRK07318 333849000823 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 333849000824 active site 333849000825 metal binding site [ion binding]; metal-binding site 333849000826 glycosyltransferase, TIGR04182 family; Region: glyco_TIGR04182 333849000827 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 333849000828 Ligand binding site; other site 333849000829 Putative Catalytic site; other site 333849000830 DXD motif; other site 333849000831 Predicted small secreted protein [Function unknown]; Region: COG5584 333849000832 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 333849000833 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 333849000834 oligomer interface [polypeptide binding]; other site 333849000835 active site 333849000836 metal binding site [ion binding]; metal-binding site 333849000837 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 333849000838 catalytic residues [active] 333849000839 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 333849000840 Ligand Binding Site [chemical binding]; other site 333849000841 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 333849000842 putative tRNA-binding site [nucleotide binding]; other site 333849000843 potential frameshift: common BLAST hit: gi|383327601|ref|YP_005353485.1| Serine protease do-like htrA 333849000844 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 333849000845 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 333849000846 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 333849000847 protein binding site [polypeptide binding]; other site 333849000848 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 333849000849 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_4; pfam14281 333849000850 Transposase, Mutator family; Region: Transposase_mut; pfam00872 333849000851 MULE transposase domain; Region: MULE; pfam10551 333849000852 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 333849000853 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 333849000854 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 333849000855 thymidine kinase; Provisional; Region: PRK04296 333849000856 Transposase, Mutator family; Region: Transposase_mut; pfam00872 333849000857 glutamate:gamma-aminobutyrate antiporter; Region: 2A0307_GadC; TIGR00910 333849000858 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 333849000859 pyridoxal 5'-phosphate binding site [chemical binding]; other site 333849000860 catalytic residue [active] 333849000861 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 333849000862 ParB-like nuclease domain; Region: ParBc; pfam02195 333849000863 potential frameshift: common BLAST hit: gi|346716404|ref|YP_004849411.1| transposase 333849000864 Integrase core domain; Region: rve_2; pfam13333 333849000865 potential frameshift: common BLAST hit: gi|346716404|ref|YP_004849411.1| transposase 333849000866 Integrase core domain; Region: rve; pfam00665 333849000867 HTH-like domain; Region: HTH_21; pfam13276 333849000868 Protein of unknown function (DUF1643); Region: DUF1643; cl01787 333849000869 Replication initiation factor; Region: Rep_trans; pfam02486 333849000870 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 333849000871 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 333849000872 catalytic residues [active] 333849000873 catalytic nucleophile [active] 333849000874 Presynaptic Site I dimer interface [polypeptide binding]; other site 333849000875 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 333849000876 Synaptic Flat tetramer interface [polypeptide binding]; other site 333849000877 Synaptic Site I dimer interface [polypeptide binding]; other site 333849000878 DNA binding site [nucleotide binding] 333849000879 Recombinase; Region: Recombinase; pfam07508 333849000880 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 333849000881 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 333849000882 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 333849000883 catalytic residues [active] 333849000884 catalytic nucleophile [active] 333849000885 Presynaptic Site I dimer interface [polypeptide binding]; other site 333849000886 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 333849000887 Synaptic Flat tetramer interface [polypeptide binding]; other site 333849000888 Synaptic Site I dimer interface [polypeptide binding]; other site 333849000889 DNA binding site [nucleotide binding] 333849000890 Recombinase; Region: Recombinase; pfam07508 333849000891 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 333849000892 phosphodiesterase; Provisional; Region: PRK12704 333849000893 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 333849000894 Helix-turn-helix domain; Region: HTH_38; pfam13936 333849000895 Integrase core domain; Region: rve; pfam00665 333849000896 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 333849000897 HsdM N-terminal domain; Region: HsdM_N; pfam12161 333849000898 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 333849000899 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 333849000900 Walker A motif; other site 333849000901 ATP binding site [chemical binding]; other site 333849000902 Walker B motif; other site 333849000903 arginine finger; other site 333849000904 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 333849000905 active pocket/dimerization site; other site 333849000906 active site 333849000907 phosphorylation site [posttranslational modification] 333849000908 PRD domain; Region: PRD; pfam00874 333849000909 PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830 333849000910 active site 333849000911 phosphorylation site [posttranslational modification] 333849000912 PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609 333849000913 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 333849000914 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 333849000915 active pocket/dimerization site; other site 333849000916 active site 333849000917 phosphorylation site [posttranslational modification] 333849000918 Protein of unknown function (DUF2961); Region: DUF2961; pfam11175 333849000919 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 333849000920 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 333849000921 nucleotide binding site [chemical binding]; other site 333849000922 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807 333849000923 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 333849000924 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 333849000925 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 333849000926 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 333849000927 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 333849000928 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 333849000929 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 333849000930 Enterocin A Immunity; Region: EntA_Immun; pfam08951 333849000931 Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225 333849000932 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 333849000933 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 333849000934 potential frameshift: common BLAST hit: gi|383328187|ref|YP_005354071.1| GNAT family acetyltransferase 333849000935 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 333849000936 Coenzyme A binding pocket [chemical binding]; other site 333849000937 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 333849000938 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 333849000939 Staphylococcal protein of unknown function (DUF960); Region: DUF960; pfam06124 333849000940 Protein of unknown function (DUF1643); Region: DUF1643; cl01787 333849000941 Mor transcription activator family; Region: Mor; cl02360 333849000942 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 333849000943 Helix-turn-helix domain; Region: HTH_38; pfam13936 333849000944 Integrase core domain; Region: rve; pfam00665 333849000945 Integrase core domain; Region: rve_3; cl15866 333849000946 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 333849000947 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 333849000948 Homeodomain-like domain; Region: HTH_23; pfam13384 333849000949 Transposase; Region: DDE_Tnp_ISL3; pfam01610 333849000950 Sulfatase; Region: Sulfatase; pfam00884 333849000951 serine/threonine transporter SstT; Provisional; Region: PRK13628 333849000952 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 333849000953 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 333849000954 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 333849000955 dimerization interface 3.5A [polypeptide binding]; other site 333849000956 active site 333849000957 6-pyruvoyl-tetrahydropterin synthase related domain; membrane protein; Region: PTPS_related; pfam10131 333849000958 potential frameshift: common BLAST hit: gi|383329115|ref|YP_005354999.1| ISEf1, transposase 333849000959 Transposase, Mutator family; Region: Transposase_mut; pfam00872 333849000960 Transposase, Mutator family; Region: Transposase_mut; pfam00872 333849000961 MULE transposase domain; Region: MULE; pfam10551 333849000962 6-pyruvoyl-tetrahydropterin synthase related domain; membrane protein; Region: PTPS_related; pfam10131 333849000963 Enterocin A Immunity; Region: EntA_Immun; pfam08951 333849000964 methionine sulfoxide reductase A; Provisional; Region: PRK14054 333849000965 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 333849000966 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 333849000967 active site 333849000968 catalytic tetrad [active] 333849000969 Transcriptional regulators [Transcription]; Region: FadR; COG2186 333849000970 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 333849000971 DNA-binding site [nucleotide binding]; DNA binding site 333849000972 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 333849000973 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 333849000974 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 333849000975 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 333849000976 beta-galactosidase; Region: BGL; TIGR03356 333849000977 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 333849000978 active site 333849000979 P-loop; other site 333849000980 phosphorylation site [posttranslational modification] 333849000981 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 333849000982 active site 333849000983 methionine cluster; other site 333849000984 phosphorylation site [posttranslational modification] 333849000985 metal binding site [ion binding]; metal-binding site 333849000986 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 333849000987 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 333849000988 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 333849000989 Coenzyme A binding pocket [chemical binding]; other site 333849000990 YrhK-like protein; Region: YrhK; pfam14145 333849000991 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 333849000992 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 333849000993 NAD binding site [chemical binding]; other site 333849000994 catalytic Zn binding site [ion binding]; other site 333849000995 structural Zn binding site [ion binding]; other site 333849000996 Streptococcal 67 kDa myosin-cross-reactive antigen like family; Region: Strep_67kDa_ant; cl17487 333849000997 Protein of unknown function (DUF1622); Region: DUF1622; pfam07784 333849000998 Protein of unknown function (DUF1622); Region: DUF1622; pfam07784 333849000999 M protein trans-acting positive regulator (MGA) HTH domain; Region: HTH_Mga; pfam08280 333849001000 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 333849001001 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 333849001002 catalytic residue [active] 333849001003 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 333849001004 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 333849001005 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 333849001006 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 333849001007 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 333849001008 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 333849001009 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 333849001010 Soluble P-type ATPase [General function prediction only]; Region: COG4087 333849001011 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 333849001012 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 333849001013 Mga helix-turn-helix domain; Region: Mga; pfam05043 333849001014 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 333849001015 Protein of unknown function (DUF419); Region: DUF419; cl15265 333849001016 Transcriptional regulator [Transcription]; Region: LysR; COG0583 333849001017 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 333849001018 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 333849001019 dimerization interface [polypeptide binding]; other site 333849001020 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 333849001021 malonate decarboxylase, epsilon subunit; Region: malonate_mdcH; TIGR03131 333849001022 malonate decarboxylase, alpha subunit; Region: mdcA; TIGR01110 333849001023 Coenzyme A transferase; Region: CoA_trans; cl17247 333849001024 malonate decarboxylase acyl carrier protein; Region: malonate_delta; TIGR03130 333849001025 malonate decarboxylase, beta subunit; Region: malonate_beta; TIGR03133 333849001026 malonate decarboxylase, gamma subunit; Region: malonate_gamma; TIGR03134 333849001027 malonate decarboxylase holo-[acyl-carrier-protein] synthase; Region: malonate_mdcG; TIGR03135 333849001028 Phosphoribosyl-dephospho-CoA transferase MdcG; Region: MdcG; pfam10620 333849001029 Acyltransferase family; Region: Acyl_transf_3; pfam01757 333849001030 triphosphoribosyl-dephospho-CoA synthase MdcB; Region: malonate_mdcB; TIGR03132 333849001031 Tim44-like domain; Region: Tim44; cl09208 333849001032 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 333849001033 PRD domain; Region: PRD; pfam00874 333849001034 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 333849001035 active site 333849001036 P-loop; other site 333849001037 phosphorylation site [posttranslational modification] 333849001038 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 333849001039 active site 333849001040 phosphorylation site [posttranslational modification] 333849001041 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 333849001042 active site 333849001043 P-loop; other site 333849001044 phosphorylation site [posttranslational modification] 333849001045 putative transposase OrfB; Reviewed; Region: PHA02517 333849001046 HTH-like domain; Region: HTH_21; pfam13276 333849001047 Integrase core domain; Region: rve; pfam00665 333849001048 Integrase core domain; Region: rve_2; pfam13333 333849001049 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 333849001050 Helix-turn-helix domain; Region: HTH_28; pfam13518 333849001051 Helix-turn-helix domain; Region: HTH_28; pfam13518 333849001052 Winged helix-turn helix; Region: HTH_29; pfam13551 333849001053 Homeodomain-like domain; Region: HTH_32; pfam13565 333849001054 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: PRK12997 333849001055 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 333849001056 intersubunit interface [polypeptide binding]; other site 333849001057 active site 333849001058 zinc binding site [ion binding]; other site 333849001059 Na+ binding site [ion binding]; other site 333849001060 AAA domain; Region: AAA_18; pfam13238 333849001061 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 333849001062 Walker A motif; other site 333849001063 ATP binding site [chemical binding]; other site 333849001064 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 333849001065 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 333849001066 nudix motif; other site 333849001067 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 333849001068 MarR family; Region: MarR; pfam01047 333849001069 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 333849001070 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 333849001071 Coenzyme A binding pocket [chemical binding]; other site 333849001072 Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382 333849001073 B3/4 domain; Region: B3_4; pfam03483 333849001074 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 333849001075 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 333849001076 active site 333849001077 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 333849001078 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 333849001079 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 333849001080 Ca binding site [ion binding]; other site 333849001081 active site 333849001082 catalytic site [active] 333849001083 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 333849001084 beta-galactosidase; Region: BGL; TIGR03356 333849001085 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 333849001086 HTH domain; Region: HTH_11; pfam08279 333849001087 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 333849001088 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 333849001089 active site turn [active] 333849001090 phosphorylation site [posttranslational modification] 333849001091 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 333849001092 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 333849001093 HPr interaction site; other site 333849001094 glycerol kinase (GK) interaction site [polypeptide binding]; other site 333849001095 active site 333849001096 phosphorylation site [posttranslational modification] 333849001097 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 333849001098 beta-galactosidase; Region: BGL; TIGR03356 333849001099 Transcriptional regulators [Transcription]; Region: MarR; COG1846 333849001100 MarR family; Region: MarR; pfam01047 333849001101 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 333849001102 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 333849001103 putative active site [active] 333849001104 putative FMN binding site [chemical binding]; other site 333849001105 putative substrate binding site [chemical binding]; other site 333849001106 putative catalytic residue [active] 333849001107 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 333849001108 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 333849001109 potential catalytic triad [active] 333849001110 conserved cys residue [active] 333849001111 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 333849001112 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 333849001113 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 333849001114 Mga helix-turn-helix domain; Region: Mga; pfam05043 333849001115 potential frameshift: common BLAST hit: gi|383327697|ref|YP_005353581.1| glycerol kinase 333849001116 glycerol kinase; Provisional; Region: glpK; PRK00047 333849001117 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 333849001118 N- and C-terminal domain interface [polypeptide binding]; other site 333849001119 active site 333849001120 MgATP binding site [chemical binding]; other site 333849001121 catalytic site [active] 333849001122 metal binding site [ion binding]; metal-binding site 333849001123 glycerol binding site [chemical binding]; other site 333849001124 homotetramer interface [polypeptide binding]; other site 333849001125 homodimer interface [polypeptide binding]; other site 333849001126 FBP binding site [chemical binding]; other site 333849001127 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 333849001128 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 333849001129 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 333849001130 amphipathic channel; other site 333849001131 Asn-Pro-Ala signature motifs; other site 333849001132 MutS domain III; Region: MutS_III; pfam05192 333849001133 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 333849001134 Walker A/P-loop; other site 333849001135 ATP binding site [chemical binding]; other site 333849001136 Q-loop/lid; other site 333849001137 ABC transporter signature motif; other site 333849001138 Walker B; other site 333849001139 D-loop; other site 333849001140 H-loop/switch region; other site 333849001141 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 333849001142 DsrE/DsrF-like family; Region: DrsE; cl00672 333849001143 Uncharacterized protein YrkD from Bacillus subtilis and related domains; this domain superfamily was previously known as part of DUF156; Region: BsYrkD-like_DUF156; cd10155 333849001144 putative homodimer interface [polypeptide binding]; other site 333849001145 putative homotetramer interface [polypeptide binding]; other site 333849001146 putative metal binding site [ion binding]; other site 333849001147 putative homodimer-homodimer interface [polypeptide binding]; other site 333849001148 putative allosteric switch controlling residues; other site 333849001149 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 333849001150 active site residue [active] 333849001151 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 333849001152 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 333849001153 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 333849001154 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 333849001155 Member of the Rhodanese Homology Domain superfamily. Included in this CD are the Lactococcus lactis NADH oxidase, Bacillus cereus NADH dehydrogenase, and Bacteroides thetaiotaomicron pyridine nucleotide-disulphide oxidoreductase, and similar...; Region: RHOD_Pyr_redox; cd01524 333849001156 active site residue [active] 333849001157 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 333849001158 Part of AAA domain; Region: AAA_19; pfam13245 333849001159 Family description; Region: UvrD_C_2; pfam13538 333849001160 N-glycosyltransferase; Provisional; Region: PRK11204 333849001161 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 333849001162 DXD motif; other site 333849001163 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 333849001164 dihydroxyacetone kinase, phosphotransfer subunit; Region: dha_pts; TIGR02364 333849001165 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 333849001166 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 333849001167 dihydroxyacetone kinase, phosphoprotein-dependent, L subunit; Region: dha_L_ycgS; TIGR02365 333849001168 Glucose-6-phosphate 1-dehydrogenase (EC 1.1.1.49); Region: G6PD_bact; pfam10786 333849001169 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 333849001170 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 333849001171 ligand binding site [chemical binding]; other site 333849001172 flexible hinge region; other site 333849001173 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 333849001174 putative switch regulator; other site 333849001175 non-specific DNA interactions [nucleotide binding]; other site 333849001176 DNA binding site [nucleotide binding] 333849001177 sequence specific DNA binding site [nucleotide binding]; other site 333849001178 putative cAMP binding site [chemical binding]; other site 333849001179 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 333849001180 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 333849001181 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 333849001182 Walker A/P-loop; other site 333849001183 ATP binding site [chemical binding]; other site 333849001184 Q-loop/lid; other site 333849001185 ABC transporter signature motif; other site 333849001186 Walker B; other site 333849001187 D-loop; other site 333849001188 H-loop/switch region; other site 333849001189 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 333849001190 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 333849001191 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 333849001192 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 333849001193 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 333849001194 putative active site [active] 333849001195 T-box leader; HMPREF0351_nc10003 333849001196 tyrosyl-tRNA synthetase; Provisional; Region: PRK13354 333849001197 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 333849001198 active site 333849001199 HIGH motif; other site 333849001200 dimer interface [polypeptide binding]; other site 333849001201 KMSKS motif; other site 333849001202 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 333849001203 RNA binding surface [nucleotide binding]; other site 333849001204 tyrosine decarboxylase, Enterococcus type; Region: tyr_de_CO2_Ent; TIGR03811 333849001205 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 333849001206 catalytic residue [active] 333849001207 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 333849001208 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 333849001209 Transcriptional regulators [Transcription]; Region: PurR; COG1609 333849001210 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 333849001211 DNA binding site [nucleotide binding] 333849001212 domain linker motif; other site 333849001213 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 333849001214 putative dimerization interface [polypeptide binding]; other site 333849001215 putative ligand binding site [chemical binding]; other site 333849001216 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 333849001217 active site 333849001218 catalytic residues [active] 333849001219 beta-phosphoglucomutase; Region: bPGM; TIGR01990 333849001220 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 333849001221 motif II; other site 333849001222 maltose phosphorylase; Provisional; Region: PRK13807 333849001223 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 333849001224 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 333849001225 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 333849001226 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 333849001227 PTS system, IIBC component; Region: PTS-II-BC-unk1; TIGR02003 333849001228 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 333849001229 active site turn [active] 333849001230 phosphorylation site [posttranslational modification] 333849001231 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 333849001232 HPr interaction site; other site 333849001233 glycerol kinase (GK) interaction site [polypeptide binding]; other site 333849001234 active site 333849001235 phosphorylation site [posttranslational modification] 333849001236 Streptococcus agalactiae RgfB, part of a putative two component signal transduction system, and related proteins; Region: RgfB-like; cd09079 333849001237 putative catalytic site [active] 333849001238 putative metal binding site [ion binding]; other site 333849001239 putative phosphate binding site [ion binding]; other site 333849001240 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 333849001241 active site 333849001242 catalytic site [active] 333849001243 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 333849001244 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 333849001245 Coenzyme A binding pocket [chemical binding]; other site 333849001246 Phenolic acid decarboxylase (PAD); Region: PA_decarbox; cl01382 333849001247 Predicted transcriptional regulators [Transcription]; Region: COG1695 333849001248 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 333849001249 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 333849001250 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 333849001251 DNA binding residues [nucleotide binding] 333849001252 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 333849001253 putative dimer interface [polypeptide binding]; other site 333849001254 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 333849001255 Major Facilitator Superfamily; Region: MFS_1; pfam07690 333849001256 putative substrate translocation pore; other site 333849001257 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 333849001258 Urea transporter; Region: UT; cl01829 333849001259 Domain of unknown function (DUF1905); Region: DUF1905; pfam08922 333849001260 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 333849001261 Flavoprotein; Region: Flavoprotein; pfam02441 333849001262 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; pfam01977 333849001263 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 333849001264 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 333849001265 Walker A/P-loop; other site 333849001266 ATP binding site [chemical binding]; other site 333849001267 Q-loop/lid; other site 333849001268 ABC transporter signature motif; other site 333849001269 Walker B; other site 333849001270 D-loop; other site 333849001271 H-loop/switch region; other site 333849001272 FtsX-like permease family; Region: FtsX; pfam02687 333849001273 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 333849001274 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 333849001275 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 333849001276 active site 333849001277 phosphorylation site [posttranslational modification] 333849001278 intermolecular recognition site; other site 333849001279 dimerization interface [polypeptide binding]; other site 333849001280 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 333849001281 DNA binding site [nucleotide binding] 333849001282 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 333849001283 HAMP domain; Region: HAMP; pfam00672 333849001284 dimerization interface [polypeptide binding]; other site 333849001285 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 333849001286 dimer interface [polypeptide binding]; other site 333849001287 phosphorylation site [posttranslational modification] 333849001288 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 333849001289 ATP binding site [chemical binding]; other site 333849001290 Mg2+ binding site [ion binding]; other site 333849001291 G-X-G motif; other site 333849001292 Transcriptional regulator [Transcription]; Region: LysR; COG0583 333849001293 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 333849001294 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 333849001295 dimerization interface [polypeptide binding]; other site 333849001296 Protein of unknown function (DUF554); Region: DUF554; pfam04474 333849001297 Predicted transcriptional regulators [Transcription]; Region: COG1695 333849001298 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 333849001299 dimerization interface [polypeptide binding]; other site 333849001300 putative Zn2+ binding site [ion binding]; other site 333849001301 putative DNA binding site [nucleotide binding]; other site 333849001302 Predicted membrane protein [Function unknown]; Region: COG4709 333849001303 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 333849001304 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_2; cd03402 333849001305 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 333849001306 Protein of unknown function (DUF1093); Region: DUF1093; cl02185 333849001307 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 333849001308 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 333849001309 Walker A/P-loop; other site 333849001310 ATP binding site [chemical binding]; other site 333849001311 Q-loop/lid; other site 333849001312 ABC transporter signature motif; other site 333849001313 Walker B; other site 333849001314 D-loop; other site 333849001315 H-loop/switch region; other site 333849001316 FtsX-like permease family; Region: FtsX; pfam02687 333849001317 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 333849001318 active site 333849001319 catalytic residues [active] 333849001320 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 333849001321 NlpC/P60 family; Region: NLPC_P60; pfam00877 333849001322 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 333849001323 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cl00164 333849001324 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 333849001325 active site turn [active] 333849001326 phosphorylation site [posttranslational modification] 333849001327 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 333849001328 D-ribose pyranase; Provisional; Region: PRK11797 333849001329 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 333849001330 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 333849001331 substrate binding site [chemical binding]; other site 333849001332 dimer interface [polypeptide binding]; other site 333849001333 ATP binding site [chemical binding]; other site 333849001334 Transcriptional regulators [Transcription]; Region: PurR; COG1609 333849001335 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 333849001336 DNA binding site [nucleotide binding] 333849001337 domain linker motif; other site 333849001338 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 333849001339 dimerization interface [polypeptide binding]; other site 333849001340 ligand binding site [chemical binding]; other site 333849001341 Isochorismatase family; Region: Isochorismatase; pfam00857 333849001342 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 333849001343 catalytic triad [active] 333849001344 conserved cis-peptide bond; other site 333849001345 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 333849001346 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 333849001347 Walker A/P-loop; other site 333849001348 ATP binding site [chemical binding]; other site 333849001349 Q-loop/lid; other site 333849001350 ABC transporter signature motif; other site 333849001351 Walker B; other site 333849001352 D-loop; other site 333849001353 H-loop/switch region; other site 333849001354 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 333849001355 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 333849001356 FtsX-like permease family; Region: FtsX; pfam02687 333849001357 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 333849001358 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 333849001359 Ca binding site [ion binding]; other site 333849001360 active site 333849001361 catalytic site [active] 333849001362 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 333849001363 Domain of unknown function DUF20; Region: UPF0118; pfam01594 333849001364 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 333849001365 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 333849001366 metal binding site [ion binding]; metal-binding site 333849001367 YodA lipocalin-like domain; Region: YodA; pfam09223 333849001368 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 333849001369 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 333849001370 active site 333849001371 phosphorylation site [posttranslational modification] 333849001372 intermolecular recognition site; other site 333849001373 LytTr DNA-binding domain; Region: LytTR; pfam04397 333849001374 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 333849001375 Accessory gene regulator B; Region: AgrB; pfam04647 333849001376 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 333849001377 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 333849001378 Substrate-binding site [chemical binding]; other site 333849001379 Substrate specificity [chemical binding]; other site 333849001380 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 333849001381 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 333849001382 Part of AAA domain; Region: AAA_19; pfam13245 333849001383 Family description; Region: UvrD_C_2; pfam13538 333849001384 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 333849001385 ArsC family; Region: ArsC; pfam03960 333849001386 putative catalytic residues [active] 333849001387 thiol/disulfide switch; other site 333849001388 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 333849001389 ArsC family; Region: ArsC; pfam03960 333849001390 putative catalytic residues [active] 333849001391 thiol/disulfide switch; other site 333849001392 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 333849001393 catalytic residues [active] 333849001394 dimer interface [polypeptide binding]; other site 333849001395 S-ribosylhomocysteinase; Provisional; Region: PRK02260 333849001396 cystathionine gamma-synthase/cystathionine beta-lyase; Validated; Region: PRK06176 333849001397 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 333849001398 homodimer interface [polypeptide binding]; other site 333849001399 substrate-cofactor binding pocket; other site 333849001400 pyridoxal 5'-phosphate binding site [chemical binding]; other site 333849001401 catalytic residue [active] 333849001402 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 333849001403 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 333849001404 dimer interface [polypeptide binding]; other site 333849001405 pyridoxal 5'-phosphate binding site [chemical binding]; other site 333849001406 catalytic residue [active] 333849001407 elongation factor P; Validated; Region: PRK00529 333849001408 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 333849001409 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 333849001410 RNA binding site [nucleotide binding]; other site 333849001411 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 333849001412 RNA binding site [nucleotide binding]; other site 333849001413 diaminopimelate decarboxylase; Region: lysA; TIGR01048 333849001414 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 333849001415 active site 333849001416 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 333849001417 substrate binding site [chemical binding]; other site 333849001418 catalytic residues [active] 333849001419 dimer interface [polypeptide binding]; other site 333849001420 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 333849001421 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 333849001422 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 333849001423 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 333849001424 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 333849001425 dimer interface [polypeptide binding]; other site 333849001426 active site 333849001427 catalytic residue [active] 333849001428 dihydrodipicolinate reductase; Provisional; Region: PRK00048 333849001429 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 333849001430 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 333849001431 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 333849001432 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 333849001433 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 333849001434 active site 333849001435 trimer interface [polypeptide binding]; other site 333849001436 substrate binding site [chemical binding]; other site 333849001437 CoA binding site [chemical binding]; other site 333849001438 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 333849001439 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 333849001440 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 333849001441 aspartate kinase; Reviewed; Region: PRK09034 333849001442 putative catalytic residues [active] 333849001443 putative nucleotide binding site [chemical binding]; other site 333849001444 putative aspartate binding site [chemical binding]; other site 333849001445 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 333849001446 allosteric regulatory residue; other site 333849001447 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 333849001448 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 333849001449 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 333849001450 metal binding site [ion binding]; metal-binding site 333849001451 dimer interface [polypeptide binding]; other site 333849001452 aromatic amino acid aminotransferase; Validated; Region: PRK07309 333849001453 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 333849001454 pyridoxal 5'-phosphate binding site [chemical binding]; other site 333849001455 homodimer interface [polypeptide binding]; other site 333849001456 catalytic residue [active] 333849001457 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 333849001458 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 333849001459 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 333849001460 HTH-like domain; Region: HTH_21; pfam13276 333849001461 Integrase core domain; Region: rve; pfam00665 333849001462 Integrase core domain; Region: rve_2; pfam13333 333849001463 Predicted membrane protein [Function unknown]; Region: COG2323 333849001464 DNA polymerase IV; Reviewed; Region: PRK03103 333849001465 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 333849001466 active site 333849001467 DNA binding site [nucleotide binding] 333849001468 galactokinase; Provisional; Region: PRK05322 333849001469 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 333849001470 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 333849001471 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 333849001472 active site 333849001473 catalytic residues [active] 333849001474 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 333849001475 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 333849001476 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 333849001477 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 333849001478 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 333849001479 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 333849001480 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 333849001481 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 333849001482 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 333849001483 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 333849001484 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 333849001485 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 333849001486 ABC-ATPase subunit interface; other site 333849001487 dimer interface [polypeptide binding]; other site 333849001488 putative PBP binding regions; other site 333849001489 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 333849001490 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 333849001491 metal binding site [ion binding]; metal-binding site 333849001492 epoxyqueuosine reductase; Region: TIGR00276 333849001493 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 333849001494 4Fe-4S binding domain; Region: Fer4_6; pfam12837 333849001495 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 333849001496 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270 333849001497 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 333849001498 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 333849001499 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 333849001500 putative substrate translocation pore; other site 333849001501 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 333849001502 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 333849001503 Arginine repressor [Transcription]; Region: ArgR; COG1438 333849001504 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 333849001505 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 333849001506 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 333849001507 active site 333849001508 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 333849001509 substrate binding site [chemical binding]; other site 333849001510 metal binding site [ion binding]; metal-binding site 333849001511 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 333849001512 pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK07251 333849001513 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 333849001514 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 333849001515 Isochorismatase family; Region: Isochorismatase; pfam00857 333849001516 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 333849001517 catalytic triad [active] 333849001518 conserved cis-peptide bond; other site 333849001519 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 333849001520 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 333849001521 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 333849001522 Uncharacterized ACR, COG2135; Region: DUF159; cl03646 333849001523 Flavin Reductases; Region: FlaRed; cl00801 333849001524 PemK-like protein; Region: PemK; pfam02452 333849001525 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 333849001526 dimanganese center [ion binding]; other site 333849001527 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 333849001528 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 333849001529 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 333849001530 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 333849001531 dimer interface [polypeptide binding]; other site 333849001532 conserved gate region; other site 333849001533 putative PBP binding loops; other site 333849001534 ABC-ATPase subunit interface; other site 333849001535 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 333849001536 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 333849001537 dimer interface [polypeptide binding]; other site 333849001538 conserved gate region; other site 333849001539 putative PBP binding loops; other site 333849001540 ABC-ATPase subunit interface; other site 333849001541 Protein of unknown function, DUF624; Region: DUF624; pfam04854 333849001542 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 333849001543 active site 333849001544 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 333849001545 Selenocysteine-specific translation elongation factor [Translation, ribosomal structure and biogenesis]; Region: SelB; COG3276 333849001546 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 333849001547 metal ion-dependent adhesion site (MIDAS); other site 333849001548 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 333849001549 Cna protein B-type domain; Region: Cna_B; pfam05738 333849001550 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 333849001551 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 333849001552 active site 333849001553 catalytic site [active] 333849001554 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 333849001555 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 333849001556 active site 333849001557 phosphorylation site [posttranslational modification] 333849001558 intermolecular recognition site; other site 333849001559 dimerization interface [polypeptide binding]; other site 333849001560 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 333849001561 DNA binding site [nucleotide binding] 333849001562 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 333849001563 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 333849001564 dimer interface [polypeptide binding]; other site 333849001565 phosphorylation site [posttranslational modification] 333849001566 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 333849001567 ATP binding site [chemical binding]; other site 333849001568 Mg2+ binding site [ion binding]; other site 333849001569 G-X-G motif; other site 333849001570 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 333849001571 amino acid transporter; Region: 2A0306; TIGR00909 333849001572 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 333849001573 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 333849001574 5-bromo-4-chloroindolyl phosphate hydrolysis protein; Region: Halogen_Hydrol; pfam10112 333849001575 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 333849001576 dimer interface [polypeptide binding]; other site 333849001577 ADP-ribose binding site [chemical binding]; other site 333849001578 active site 333849001579 nudix motif; other site 333849001580 metal binding site [ion binding]; metal-binding site 333849001581 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 333849001582 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 333849001583 Isochorismatase family; Region: Isochorismatase; pfam00857 333849001584 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 333849001585 catalytic triad [active] 333849001586 conserved cis-peptide bond; other site 333849001587 Right handed beta helix region; Region: Beta_helix; pfam13229 333849001588 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 333849001589 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 333849001590 active site 333849001591 Zn binding site [ion binding]; other site 333849001592 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02458 333849001593 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 333849001594 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 333849001595 active site 333849001596 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 333849001597 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 333849001598 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 333849001599 catalytic residue [active] 333849001600 Putative amino acid metabolism; Region: DUF1831; pfam08866 333849001601 H+ Antiporter protein; Region: 2A0121; TIGR00900 333849001602 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 333849001603 putative substrate translocation pore; other site 333849001604 Aquifex aeolicus AQ1575 and related proteins, metallophosphatase domain; Region: MPP_AQ1575; cd07390 333849001605 putative active site [active] 333849001606 putative metal binding site [ion binding]; other site 333849001607 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 333849001608 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 333849001609 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 333849001610 transaminase; Validated; Region: PRK07324 333849001611 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 333849001612 pyridoxal 5'-phosphate binding site [chemical binding]; other site 333849001613 homodimer interface [polypeptide binding]; other site 333849001614 catalytic residue [active] 333849001615 drug efflux system protein MdtG; Provisional; Region: PRK09874 333849001616 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 333849001617 putative substrate translocation pore; other site 333849001618 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 333849001619 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 333849001620 Uncharacterized conserved protein (DUF2183); Region: DUF2183; pfam09949 333849001621 WHG domain; Region: WHG; pfam13305 333849001622 Protein of unknown function (DUF1033); Region: DUF1033; pfam06279 333849001623 DNA topoisomerase III; Provisional; Region: PRK07726 333849001624 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 333849001625 active site 333849001626 putative metal-binding site [ion binding]; other site 333849001627 putative interdomain interaction site [polypeptide binding]; other site 333849001628 putative nucleotide binding site [chemical binding]; other site 333849001629 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 333849001630 domain I; other site 333849001631 DNA binding groove [nucleotide binding] 333849001632 phosphate binding site [ion binding]; other site 333849001633 domain II; other site 333849001634 domain III; other site 333849001635 nucleotide binding site [chemical binding]; other site 333849001636 catalytic site [active] 333849001637 domain IV; other site 333849001638 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 333849001639 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 333849001640 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 333849001641 Ligand binding site; other site 333849001642 Putative Catalytic site; other site 333849001643 DXD motif; other site 333849001644 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 333849001645 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 333849001646 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 333849001647 DNA binding site [nucleotide binding] 333849001648 active site 333849001649 Predicted membrane protein [Function unknown]; Region: COG2855 333849001650 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 333849001651 C4-dicarboxylate transporters of the Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_C4-dicarb_trans; cd09325 333849001652 gating phenylalanine in ion channel; other site 333849001653 Transcriptional regulator [Transcription]; Region: LysR; COG0583 333849001654 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 333849001655 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 333849001656 dimerization interface [polypeptide binding]; other site 333849001657 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 333849001658 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 333849001659 ArsC family; Region: ArsC; pfam03960 333849001660 putative ArsC-like catalytic residues; other site 333849001661 putative TRX-like catalytic residues [active] 333849001662 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 333849001663 lipoyl attachment site [posttranslational modification]; other site 333849001664 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 333849001665 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 333849001666 Walker A/P-loop; other site 333849001667 ATP binding site [chemical binding]; other site 333849001668 Q-loop/lid; other site 333849001669 ABC transporter signature motif; other site 333849001670 Walker B; other site 333849001671 D-loop; other site 333849001672 H-loop/switch region; other site 333849001673 NIL domain; Region: NIL; pfam09383 333849001674 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 333849001675 conserved gate region; other site 333849001676 ABC-ATPase subunit interface; other site 333849001677 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 333849001678 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 333849001679 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 333849001680 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 333849001681 Walker A/P-loop; other site 333849001682 ATP binding site [chemical binding]; other site 333849001683 Q-loop/lid; other site 333849001684 ABC transporter signature motif; other site 333849001685 Walker B; other site 333849001686 D-loop; other site 333849001687 H-loop/switch region; other site 333849001688 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 333849001689 FeS assembly protein SufD; Region: sufD; TIGR01981 333849001690 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 333849001691 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 333849001692 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 333849001693 catalytic residue [active] 333849001694 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 333849001695 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 333849001696 trimerization site [polypeptide binding]; other site 333849001697 active site 333849001698 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 333849001699 FeS assembly protein SufB; Region: sufB; TIGR01980 333849001700 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 333849001701 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 333849001702 Int/Topo IB signature motif; other site 333849001703 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 333849001704 non-specific DNA binding site [nucleotide binding]; other site 333849001705 salt bridge; other site 333849001706 sequence-specific DNA binding site [nucleotide binding]; other site 333849001707 Helix-turn-helix domain; Region: HTH_17; pfam12728 333849001708 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 333849001709 TrbC/VIRB2 family; Region: TrbC; pfam04956 333849001710 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 333849001711 non-specific DNA binding site [nucleotide binding]; other site 333849001712 salt bridge; other site 333849001713 sequence-specific DNA binding site [nucleotide binding]; other site 333849001714 TIR domain; Region: TIR_2; cl17458 333849001715 Sir2-like: Prokaryotic group of uncharacterized Sir2-like proteins which lack certain key catalytic residues and conserved zinc binding cysteines; and are members of the SIR2 superfamily of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIR2-like; cd01406 333849001716 MTH538 TIR-like domain (DUF1863); Region: DUF1863; pfam08937 333849001717 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 333849001718 Int/Topo IB signature motif; other site 333849001719 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 333849001720 non-specific DNA binding site [nucleotide binding]; other site 333849001721 salt bridge; other site 333849001722 sequence-specific DNA binding site [nucleotide binding]; other site 333849001723 Helix-turn-helix domain; Region: HTH_17; pfam12728 333849001724 CHC2 zinc finger; Region: zf-CHC2; cl17510 333849001725 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 333849001726 non-specific DNA binding site [nucleotide binding]; other site 333849001727 salt bridge; other site 333849001728 sequence-specific DNA binding site [nucleotide binding]; other site 333849001729 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 333849001730 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 333849001731 non-specific DNA binding site [nucleotide binding]; other site 333849001732 salt bridge; other site 333849001733 sequence-specific DNA binding site [nucleotide binding]; other site 333849001734 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 333849001735 HsdM N-terminal domain; Region: HsdM_N; pfam12161 333849001736 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 333849001737 Methyltransferase domain; Region: Methyltransf_26; pfam13659 333849001738 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 333849001739 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 333849001740 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 333849001741 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 333849001742 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 333849001743 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 333849001744 ATP binding site [chemical binding]; other site 333849001745 putative Mg++ binding site [ion binding]; other site 333849001746 Transposase domain (DUF772); Region: DUF772; pfam05598 333849001747 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 333849001748 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 333849001749 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 333849001750 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 333849001751 non-specific DNA binding site [nucleotide binding]; other site 333849001752 salt bridge; other site 333849001753 sequence-specific DNA binding site [nucleotide binding]; other site 333849001754 Protein of unknown function (DUF1093); Region: DUF1093; cl02185 333849001755 Protein of unknown function (DUF1430); Region: DUF1430; pfam07242 333849001756 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 333849001757 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 333849001758 Walker A/P-loop; other site 333849001759 ATP binding site [chemical binding]; other site 333849001760 Q-loop/lid; other site 333849001761 ABC transporter signature motif; other site 333849001762 Walker B; other site 333849001763 D-loop; other site 333849001764 H-loop/switch region; other site 333849001765 foldase protein PrsA; Reviewed; Region: prsA; PRK01326 333849001766 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 333849001767 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 333849001768 WxL domain surface cell wall-binding; Region: WxL; pfam13731 333849001769 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 333849001770 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 333849001771 WxL domain surface cell wall-binding; Region: WxL; pfam13731 333849001772 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 333849001773 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 333849001774 active site 333849001775 phosphorylation site [posttranslational modification] 333849001776 intermolecular recognition site; other site 333849001777 dimerization interface [polypeptide binding]; other site 333849001778 LytTr DNA-binding domain; Region: LytTR; smart00850 333849001779 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 333849001780 Predicted transcriptional regulators [Transcription]; Region: COG1733 333849001781 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 333849001782 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537 333849001783 homodimer interface [polypeptide binding]; other site 333849001784 chemical substrate binding site [chemical binding]; other site 333849001785 oligomer interface [polypeptide binding]; other site 333849001786 metal binding site [ion binding]; metal-binding site 333849001787 Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165 333849001788 active site 333849001789 catalytic site [active] 333849001790 transcriptional antiterminator BglG; Provisional; Region: PRK09772 333849001791 CAT RNA binding domain; Region: CAT_RBD; smart01061 333849001792 PRD domain; Region: PRD; pfam00874 333849001793 PRD domain; Region: PRD; pfam00874 333849001794 potential frameshift: common BLAST hit: gi|383327920|ref|YP_005353804.1| PTS system beta-glucoside-specific transporter subunit IIABC 333849001795 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 333849001796 active site turn [active] 333849001797 phosphorylation site [posttranslational modification] 333849001798 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 333849001799 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 333849001800 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 333849001801 HPr interaction site; other site 333849001802 glycerol kinase (GK) interaction site [polypeptide binding]; other site 333849001803 active site 333849001804 phosphorylation site [posttranslational modification] 333849001805 potential frameshift: common BLAST hit: gi|383327921|ref|YP_005353805.1| 6-phospho-beta-glucosidase 333849001806 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 333849001807 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 333849001808 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 333849001809 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 333849001810 DNA-binding site [nucleotide binding]; DNA binding site 333849001811 UTRA domain; Region: UTRA; pfam07702 333849001812 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425 333849001813 Possible lysine decarboxylase; Region: Lysine_decarbox; pfam03641 333849001814 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014 333849001815 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 333849001816 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 333849001817 Substrate-binding site [chemical binding]; other site 333849001818 Substrate specificity [chemical binding]; other site 333849001819 Transcriptional regulators [Transcription]; Region: PurR; COG1609 333849001820 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 333849001821 DNA binding site [nucleotide binding] 333849001822 domain linker motif; other site 333849001823 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 333849001824 ligand binding site [chemical binding]; other site 333849001825 dimerization interface [polypeptide binding]; other site 333849001826 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 333849001827 beta-galactosidase; Region: BGL; TIGR03356 333849001828 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 333849001829 Sulfatase; Region: Sulfatase; pfam00884 333849001830 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 333849001831 non-specific DNA binding site [nucleotide binding]; other site 333849001832 salt bridge; other site 333849001833 sequence-specific DNA binding site [nucleotide binding]; other site 333849001834 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 333849001835 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 333849001836 active site 333849001837 multimer interface [polypeptide binding]; other site 333849001838 ykoK leader; HMPREF0351_nc10005 333849001839 magnesium-transporting ATPase; Provisional; Region: PRK15122 333849001840 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 333849001841 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 333849001842 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 333849001843 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 333849001844 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 333849001845 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 333849001846 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 333849001847 motif II; other site 333849001848 T-box leader; HMPREF0351_nc10006 333849001849 T-box leader; HMPREF0351_nc10007 333849001850 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 333849001851 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 333849001852 Walker A/P-loop; other site 333849001853 ATP binding site [chemical binding]; other site 333849001854 Q-loop/lid; other site 333849001855 ABC transporter signature motif; other site 333849001856 Walker B; other site 333849001857 D-loop; other site 333849001858 H-loop/switch region; other site 333849001859 NIL domain; Region: NIL; pfam09383 333849001860 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 333849001861 dimer interface [polypeptide binding]; other site 333849001862 conserved gate region; other site 333849001863 ABC-ATPase subunit interface; other site 333849001864 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 333849001865 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 333849001866 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 333849001867 amidohydrolase; Region: amidohydrolases; TIGR01891 333849001868 metal binding site [ion binding]; metal-binding site 333849001869 T-box leader; HMPREF0351_nc10008 333849001870 Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553 333849001871 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 333849001872 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 333849001873 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 333849001874 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 333849001875 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 333849001876 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 333849001877 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 333849001878 ABC transporter; Region: ABC_tran_2; pfam12848 333849001879 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 333849001880 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 333849001881 catalytic core [active] 333849001882 Uncharacterized conserved protein [Function unknown]; Region: COG3589 333849001883 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 333849001884 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 333849001885 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 333849001886 putative active site [active] 333849001887 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 333849001888 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 333849001889 active site turn [active] 333849001890 phosphorylation site [posttranslational modification] 333849001891 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 333849001892 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 333849001893 HPr interaction site; other site 333849001894 glycerol kinase (GK) interaction site [polypeptide binding]; other site 333849001895 active site 333849001896 phosphorylation site [posttranslational modification] 333849001897 NrdI Flavodoxin like; Region: Flavodoxin_NdrI; cl17293 333849001898 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 333849001899 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 333849001900 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 333849001901 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 333849001902 Walker A/P-loop; other site 333849001903 ATP binding site [chemical binding]; other site 333849001904 Q-loop/lid; other site 333849001905 ABC transporter signature motif; other site 333849001906 Walker B; other site 333849001907 D-loop; other site 333849001908 H-loop/switch region; other site 333849001909 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 333849001910 Protein of unknown function (DUF969); Region: DUF969; pfam06149 333849001911 Predicted membrane protein [Function unknown]; Region: COG3817 333849001912 Protein of unknown function (DUF979); Region: DUF979; pfam06166 333849001913 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 333849001914 putative substrate binding pocket [chemical binding]; other site 333849001915 AC domain interface; other site 333849001916 catalytic triad [active] 333849001917 AB domain interface; other site 333849001918 interchain disulfide; other site 333849001919 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 333849001920 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 333849001921 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 333849001922 putative metal binding site [ion binding]; other site 333849001923 Protein of unknown function (DUF2874); Region: DUF2874; pfam11396 333849001924 cxxc_20_cxxc protein; Region: cxxc_20_cxxc; TIGR04104 333849001925 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 333849001926 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 333849001927 Coenzyme A binding pocket [chemical binding]; other site 333849001928 Tubby C 2; Region: Tub_2; cl02043 333849001929 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 333849001930 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 333849001931 active site 333849001932 motif I; other site 333849001933 motif II; other site 333849001934 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 333849001935 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 333849001936 ligand binding site [chemical binding]; other site 333849001937 active site 333849001938 UGI interface [polypeptide binding]; other site 333849001939 catalytic site [active] 333849001940 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 333849001941 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 333849001942 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 333849001943 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 333849001944 Coenzyme A binding pocket [chemical binding]; other site 333849001945 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 333849001946 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 333849001947 active site 333849001948 catalytic site [active] 333849001949 substrate binding site [chemical binding]; other site 333849001950 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 333849001951 active site 333849001952 putative catalytic site [active] 333849001953 DNA binding site [nucleotide binding] 333849001954 putative phosphate binding site [ion binding]; other site 333849001955 metal binding site A [ion binding]; metal-binding site 333849001956 AP binding site [nucleotide binding]; other site 333849001957 metal binding site B [ion binding]; metal-binding site 333849001958 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 333849001959 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 333849001960 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 333849001961 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 333849001962 FAD binding domain; Region: FAD_binding_4; pfam01565 333849001963 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 333849001964 Mga helix-turn-helix domain; Region: Mga; pfam05043 333849001965 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 333849001966 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 333849001967 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 333849001968 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 333849001969 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 333849001970 Coenzyme A binding pocket [chemical binding]; other site 333849001971 fumarate reductase flavoprotein subunit; Validated; Region: PRK06481 333849001972 L-aspartate oxidase; Provisional; Region: PRK06175 333849001973 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 333849001974 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 333849001975 NAD(P) binding site [chemical binding]; other site 333849001976 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 333849001977 NADH(P)-binding; Region: NAD_binding_10; pfam13460 333849001978 NAD(P) binding site [chemical binding]; other site 333849001979 putative active site [active] 333849001980 Predicted membrane protein [Function unknown]; Region: COG4684 333849001981 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 333849001982 phosphopantothenoylcysteine decarboxylase; Validated; Region: PRK07313 333849001983 Flavoprotein; Region: Flavoprotein; pfam02441 333849001984 DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410 333849001985 Yhdh and yhfp-like putative quinone oxidoreductases; Region: MDR_yhdh_yhfp; cd05280 333849001986 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 333849001987 NADP binding site [chemical binding]; other site 333849001988 dimer interface [polypeptide binding]; other site 333849001989 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 333849001990 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 333849001991 non-specific DNA binding site [nucleotide binding]; other site 333849001992 salt bridge; other site 333849001993 sequence-specific DNA binding site [nucleotide binding]; other site 333849001994 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 333849001995 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 333849001996 Walker A/P-loop; other site 333849001997 ATP binding site [chemical binding]; other site 333849001998 Q-loop/lid; other site 333849001999 ABC transporter signature motif; other site 333849002000 Walker B; other site 333849002001 D-loop; other site 333849002002 H-loop/switch region; other site 333849002003 TOBE domain; Region: TOBE_2; pfam08402 333849002004 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 333849002005 dimer interface [polypeptide binding]; other site 333849002006 conserved gate region; other site 333849002007 putative PBP binding loops; other site 333849002008 ABC-ATPase subunit interface; other site 333849002009 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 333849002010 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 333849002011 dimer interface [polypeptide binding]; other site 333849002012 conserved gate region; other site 333849002013 putative PBP binding loops; other site 333849002014 ABC-ATPase subunit interface; other site 333849002015 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 333849002016 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 333849002017 Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775 333849002018 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 333849002019 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 333849002020 Walker A motif; other site 333849002021 ATP binding site [chemical binding]; other site 333849002022 Walker B motif; other site 333849002023 arginine finger; other site 333849002024 Transcriptional antiterminator [Transcription]; Region: COG3933 333849002025 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 333849002026 active site 333849002027 active pocket/dimerization site; other site 333849002028 phosphorylation site [posttranslational modification] 333849002029 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 333849002030 active pocket/dimerization site; other site 333849002031 active site 333849002032 phosphorylation site [posttranslational modification] 333849002033 PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830 333849002034 active site 333849002035 phosphorylation site [posttranslational modification] 333849002036 PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609 333849002037 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 333849002038 Protein of unknown function (DUF2961); Region: DUF2961; pfam11175 333849002039 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 333849002040 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 333849002041 nucleotide binding site [chemical binding]; other site 333849002042 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 333849002043 transcriptional repressor DicA; Reviewed; Region: PRK09706 333849002044 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 333849002045 non-specific DNA binding site [nucleotide binding]; other site 333849002046 salt bridge; other site 333849002047 sequence-specific DNA binding site [nucleotide binding]; other site 333849002048 Replication initiation factor; Region: Rep_trans; pfam02486 333849002049 Domain of unknown function (DUF3173); Region: DUF3173; pfam11372 333849002050 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 333849002051 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 333849002052 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 333849002053 Int/Topo IB signature motif; other site 333849002054 T-box leader; HMPREF0351_nc10009 333849002055 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 333849002056 substrate binding site [chemical binding]; other site 333849002057 THF binding site; other site 333849002058 zinc-binding site [ion binding]; other site 333849002059 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 333849002060 Helix-turn-helix domain; Region: HTH_38; pfam13936 333849002061 Integrase core domain; Region: rve; pfam00665 333849002062 Integrase core domain; Region: rve_3; cl15866 333849002063 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 333849002064 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 333849002065 DNA binding residues [nucleotide binding] 333849002066 putative dimer interface [polypeptide binding]; other site 333849002067 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 333849002068 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 333849002069 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 333849002070 CTP synthetase; Validated; Region: pyrG; PRK05380 333849002071 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 333849002072 Catalytic site [active] 333849002073 active site 333849002074 UTP binding site [chemical binding]; other site 333849002075 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 333849002076 active site 333849002077 putative oxyanion hole; other site 333849002078 catalytic triad [active] 333849002079 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 333849002080 intersubunit interface [polypeptide binding]; other site 333849002081 active site 333849002082 zinc binding site [ion binding]; other site 333849002083 Na+ binding site [ion binding]; other site 333849002084 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 333849002085 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 333849002086 hinge; other site 333849002087 active site 333849002088 transcription termination factor Rho; Provisional; Region: rho; PRK09376 333849002089 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 333849002090 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 333849002091 RNA binding site [nucleotide binding]; other site 333849002092 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 333849002093 Walker A motif; other site 333849002094 ATP binding site [chemical binding]; other site 333849002095 Walker B motif; other site 333849002096 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 333849002097 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 333849002098 active site 333849002099 phosphorylation site [posttranslational modification] 333849002100 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 333849002101 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 333849002102 active site 333849002103 P-loop; other site 333849002104 phosphorylation site [posttranslational modification] 333849002105 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 333849002106 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 333849002107 intersubunit interface [polypeptide binding]; other site 333849002108 active site 333849002109 zinc binding site [ion binding]; other site 333849002110 Na+ binding site [ion binding]; other site 333849002111 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 333849002112 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 333849002113 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 333849002114 Protein of unknown function (DUF2512); Region: DUF2512; pfam10710 333849002115 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 333849002116 Major Facilitator Superfamily; Region: MFS_1; pfam07690 333849002117 putative substrate translocation pore; other site 333849002118 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 333849002119 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 333849002120 ligand binding site [chemical binding]; other site 333849002121 flexible hinge region; other site 333849002122 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 333849002123 non-specific DNA interactions [nucleotide binding]; other site 333849002124 DNA binding site [nucleotide binding] 333849002125 sequence specific DNA binding site [nucleotide binding]; other site 333849002126 putative cAMP binding site [chemical binding]; other site 333849002127 Repair protein; Region: Repair_PSII; pfam04536 333849002128 YycH protein; Region: YycI; cl02015 333849002129 Membrane protease subunit, stomatin/prohibitin family [Amino acid transport and metabolism]; Region: COG4260 333849002130 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_5; cd03408 333849002131 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 333849002132 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 333849002133 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 333849002134 Walker A motif; other site 333849002135 ATP binding site [chemical binding]; other site 333849002136 Walker B motif; other site 333849002137 arginine finger; other site 333849002138 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 333849002139 hypothetical protein; Validated; Region: PRK00153 333849002140 recombination protein RecR; Reviewed; Region: recR; PRK00076 333849002141 RecR protein; Region: RecR; pfam02132 333849002142 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 333849002143 putative active site [active] 333849002144 putative metal-binding site [ion binding]; other site 333849002145 tetramer interface [polypeptide binding]; other site 333849002146 thymidylate kinase; Validated; Region: tmk; PRK00698 333849002147 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 333849002148 TMP-binding site; other site 333849002149 ATP-binding site [chemical binding]; other site 333849002150 Protein of unknown function (DUF970); Region: DUF970; cl17525 333849002151 DNA polymerase III subunit delta'; Validated; Region: PRK08058 333849002152 DNA polymerase III subunit delta'; Validated; Region: PRK08485 333849002153 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 333849002154 Protein of unknown function (DUF972); Region: DUF972; pfam06156 333849002155 Predicted methyltransferases [General function prediction only]; Region: COG0313 333849002156 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 333849002157 putative SAM binding site [chemical binding]; other site 333849002158 putative homodimer interface [polypeptide binding]; other site 333849002159 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 333849002160 active site 333849002161 DNA polymerase IV; Validated; Region: PRK02406 333849002162 DNA binding site [nucleotide binding] 333849002163 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 333849002164 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 333849002165 FeS/SAM binding site; other site 333849002166 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 333849002167 ATP cone domain; Region: ATP-cone; pfam03477 333849002168 Class III ribonucleotide reductase; Region: RNR_III; cd01675 333849002169 effector binding site; other site 333849002170 active site 333849002171 Zn binding site [ion binding]; other site 333849002172 glycine loop; other site 333849002173 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 333849002174 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 333849002175 Walker A/P-loop; other site 333849002176 ATP binding site [chemical binding]; other site 333849002177 Q-loop/lid; other site 333849002178 ABC transporter signature motif; other site 333849002179 Walker B; other site 333849002180 D-loop; other site 333849002181 H-loop/switch region; other site 333849002182 FtsX-like permease family; Region: FtsX; pfam02687 333849002183 D-Ala-teichoic acid biosynthesis protein; Region: DUF3687; pfam12459 333849002184 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 333849002185 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 333849002186 acyl-activating enzyme (AAE) consensus motif; other site 333849002187 AMP binding site [chemical binding]; other site 333849002188 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091 333849002189 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087 333849002190 D-alanyl-lipoteichoic acid biosynthesis protein DltD; Region: LTA_DltD; TIGR04092 333849002191 DltD N-terminal region; Region: DltD_N; pfam04915 333849002192 DltD central region; Region: DltD_M; pfam04918 333849002193 DltD C-terminal region; Region: DltD_C; pfam04914 333849002194 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 333849002195 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 333849002196 oligomer interface [polypeptide binding]; other site 333849002197 active site 333849002198 metal binding site [ion binding]; metal-binding site 333849002199 Protein of unknown function (DUF975); Region: DUF975; cl10504 333849002200 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 333849002201 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 333849002202 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 333849002203 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 333849002204 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 333849002205 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 333849002206 Catalytic site [active] 333849002207 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 333849002208 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 333849002209 S-adenosylmethionine binding site [chemical binding]; other site 333849002210 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 333849002211 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 333849002212 Sulfate transporter family; Region: Sulfate_transp; pfam00916 333849002213 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 333849002214 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 333849002215 Fe-S cluster binding site [ion binding]; other site 333849002216 active site 333849002217 ribosomal protein L21 leader; HMPREF0351_nc10010 333849002218 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 333849002219 Protein of unknown function (DUF464); Region: DUF464; pfam04327 333849002220 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 333849002221 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 333849002222 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 333849002223 Walker A motif; other site 333849002224 ATP binding site [chemical binding]; other site 333849002225 Walker B motif; other site 333849002226 arginine finger; other site 333849002227 Transcriptional antiterminator [Transcription]; Region: COG3933 333849002228 PRD domain; Region: PRD; pfam00874 333849002229 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 333849002230 active pocket/dimerization site; other site 333849002231 active site 333849002232 phosphorylation site [posttranslational modification] 333849002233 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 333849002234 active site 333849002235 phosphorylation site [posttranslational modification] 333849002236 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 333849002237 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 333849002238 active pocket/dimerization site; other site 333849002239 active site 333849002240 phosphorylation site [posttranslational modification] 333849002241 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 333849002242 active site 333849002243 phosphorylation site [posttranslational modification] 333849002244 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 333849002245 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 333849002246 Domain of unknown function (DUF956); Region: DUF956; pfam06115 333849002247 Predicted membrane protein [Function unknown]; Region: COG2261 333849002248 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 333849002249 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 333849002250 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 333849002251 active site 333849002252 Asp23 family; Region: Asp23; pfam03780 333849002253 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 333849002254 putative RNA binding site [nucleotide binding]; other site 333849002255 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14179 333849002256 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 333849002257 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 333849002258 homodimer interface [polypeptide binding]; other site 333849002259 NADP binding site [chemical binding]; other site 333849002260 substrate binding site [chemical binding]; other site 333849002261 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 333849002262 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 333849002263 generic binding surface II; other site 333849002264 generic binding surface I; other site 333849002265 Site-specific recombinase; Region: SpecificRecomb; cl15411 333849002266 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 333849002267 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 333849002268 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 333849002269 substrate binding pocket [chemical binding]; other site 333849002270 chain length determination region; other site 333849002271 substrate-Mg2+ binding site; other site 333849002272 catalytic residues [active] 333849002273 aspartate-rich region 1; other site 333849002274 active site lid residues [active] 333849002275 aspartate-rich region 2; other site 333849002276 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 333849002277 S4 RNA-binding domain; Region: S4; smart00363 333849002278 RNA binding surface [nucleotide binding]; other site 333849002279 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 333849002280 Arginine repressor [Transcription]; Region: ArgR; COG1438 333849002281 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 333849002282 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 333849002283 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 333849002284 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 333849002285 Walker A/P-loop; other site 333849002286 ATP binding site [chemical binding]; other site 333849002287 Q-loop/lid; other site 333849002288 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 333849002289 ABC transporter signature motif; other site 333849002290 Walker B; other site 333849002291 D-loop; other site 333849002292 H-loop/switch region; other site 333849002293 Protein of unknown function (DUF4044); Region: DUF4044; pfam13253 333849002294 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 333849002295 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 333849002296 Cl binding site [ion binding]; other site 333849002297 oligomer interface [polypeptide binding]; other site 333849002298 Protein of unknown function (DUF3397); Region: DUF3397; pfam11877 333849002299 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001 333849002300 MraZ protein; Region: MraZ; pfam02381 333849002301 MraZ protein; Region: MraZ; pfam02381 333849002302 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 333849002303 MraW methylase family; Region: Methyltransf_5; pfam01795 333849002304 Cell division protein FtsL; Region: FtsL; cl11433 333849002305 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 333849002306 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 333849002307 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 333849002308 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 333849002309 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 333849002310 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 333849002311 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 333849002312 Mg++ binding site [ion binding]; other site 333849002313 putative catalytic motif [active] 333849002314 putative substrate binding site [chemical binding]; other site 333849002315 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 333849002316 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002 333849002317 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 333849002318 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 333849002319 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 333849002320 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 333849002321 active site 333849002322 homodimer interface [polypeptide binding]; other site 333849002323 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 333849002324 Cell division protein FtsQ; Region: FtsQ; pfam03799 333849002325 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 333849002326 Cell division protein FtsA; Region: FtsA; smart00842 333849002327 Cell division protein FtsA; Region: FtsA; pfam14450 333849002328 Domain of unknown function (DUF3484); Region: DUF3484; pfam11983 333849002329 cell division protein FtsZ; Validated; Region: PRK09330 333849002330 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 333849002331 nucleotide binding site [chemical binding]; other site 333849002332 SulA interaction site; other site 333849002333 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 333849002334 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 333849002335 catalytic residue [active] 333849002336 Protein of unknown function (DUF552); Region: DUF552; pfam04472 333849002337 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 333849002338 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 333849002339 RNA binding surface [nucleotide binding]; other site 333849002340 DivIVA protein; Region: DivIVA; pfam05103 333849002341 DivIVA domain; Region: DivI1A_domain; TIGR03544 333849002342 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 333849002343 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 333849002344 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 333849002345 active site 333849002346 HIGH motif; other site 333849002347 nucleotide binding site [chemical binding]; other site 333849002348 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 333849002349 active site 333849002350 KMSKS motif; other site 333849002351 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 333849002352 tRNA binding surface [nucleotide binding]; other site 333849002353 anticodon binding site; other site 333849002354 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 333849002355 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 333849002356 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 333849002357 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 333849002358 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 333849002359 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 333849002360 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 333849002361 FeoA domain; Region: FeoA; pfam04023 333849002362 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 333849002363 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 333849002364 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 333849002365 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 333849002366 DEAD-like helicases superfamily; Region: DEXDc; smart00487 333849002367 ATP binding site [chemical binding]; other site 333849002368 putative Mg++ binding site [ion binding]; other site 333849002369 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 333849002370 nucleotide binding region [chemical binding]; other site 333849002371 ATP-binding site [chemical binding]; other site 333849002372 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 333849002373 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 333849002374 putative DNA binding site [nucleotide binding]; other site 333849002375 putative Zn2+ binding site [ion binding]; other site 333849002376 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 333849002377 Walker A motif; other site 333849002378 ATP binding site [chemical binding]; other site 333849002379 Walker B motif; other site 333849002380 Transcriptional antiterminator [Transcription]; Region: COG3933 333849002381 PRD domain; Region: PRD; pfam00874 333849002382 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 333849002383 active pocket/dimerization site; other site 333849002384 active site 333849002385 phosphorylation site [posttranslational modification] 333849002386 PRD domain; Region: PRD; pfam00874 333849002387 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 333849002388 active site 333849002389 P-loop; other site 333849002390 phosphorylation site [posttranslational modification] 333849002391 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 333849002392 active site 333849002393 methionine cluster; other site 333849002394 phosphorylation site [posttranslational modification] 333849002395 metal binding site [ion binding]; metal-binding site 333849002396 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 333849002397 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 333849002398 Protein of unknown function (DUF3188); Region: DUF3188; pfam11384 333849002399 Domain of unknown function (DUF3284); Region: DUF3284; pfam11687 333849002400 Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527 333849002401 Predicted acetyltransferase involved in intracellular survival and related acetyltransferases [General function prediction only]; Region: Eis; COG4552 333849002402 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 333849002403 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 333849002404 Int/Topo IB signature motif; other site 333849002405 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 333849002406 Domain of unknown function (DUF955); Region: DUF955; pfam06114 333849002407 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 333849002408 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 333849002409 non-specific DNA binding site [nucleotide binding]; other site 333849002410 salt bridge; other site 333849002411 sequence-specific DNA binding site [nucleotide binding]; other site 333849002412 Prophage antirepressor [Transcription]; Region: COG3617 333849002413 BRO family, N-terminal domain; Region: Bro-N; smart01040 333849002414 Phage antirepressor protein KilAC domain; Region: ANT; pfam03374 333849002415 non-specific DNA binding site [nucleotide binding]; other site 333849002416 salt bridge; other site 333849002417 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 333849002418 sequence-specific DNA binding site [nucleotide binding]; other site 333849002419 Domain of unknown function (DUF771); Region: DUF771; pfam05595 333849002420 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 333849002421 ORF6C domain; Region: ORF6C; pfam10552 333849002422 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; cl17752 333849002423 Protein of unknown function (DUF1071); Region: DUF1071; pfam06378 333849002424 Protein of unknown function (DUF968); Region: DUF968; pfam06147 333849002425 Helix-turn-helix domain; Region: HTH_36; pfam13730 333849002426 Protein of unknown function (DUF1140); Region: DUF1140; pfam06600 333849002427 YopX protein; Region: YopX; pfam09643 333849002428 Protein of unknown function (DUF1642); Region: DUF1642; pfam07852 333849002429 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 333849002430 AAA ATPase containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: MDN1; COG5271 333849002431 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 333849002432 active site 333849002433 Transmembrane adaptor Erv26; Region: Erv26; pfam04148 333849002434 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 333849002435 Phage portal protein; Region: Phage_portal; pfam04860 333849002436 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 333849002437 oligomer interface [polypeptide binding]; other site 333849002438 active site residues [active] 333849002439 Phage capsid family; Region: Phage_capsid; pfam05065 333849002440 Phage-related minor tail protein [Function unknown]; Region: COG5280 333849002441 membrane protein P6; Region: PHA01399 333849002442 membrane protein P6; Region: PHA01399 333849002443 Phage-related protein [Function unknown]; Region: COG4722 333849002444 Phage tail protein; Region: Sipho_tail; cl17486 333849002445 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 333849002446 Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; Region: SPEC; cl02488 333849002447 Phage uncharacterized protein (Phage_XkdX); Region: Phage_XkdX; pfam09693 333849002448 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 333849002449 amidase catalytic site [active] 333849002450 Zn binding residues [ion binding]; other site 333849002451 substrate binding site [chemical binding]; other site 333849002452 Transposase; Region: HTH_Tnp_1; pfam01527 333849002453 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 333849002454 putative transposase OrfB; Reviewed; Region: PHA02517 333849002455 Integrase core domain; Region: rve; pfam00665 333849002456 Integrase core domain; Region: rve_3; pfam13683 333849002457 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 333849002458 Helix-turn-helix domain; Region: HTH_28; pfam13518 333849002459 Helix-turn-helix domain; Region: HTH_28; pfam13518 333849002460 Winged helix-turn helix; Region: HTH_29; pfam13551 333849002461 Homeodomain-like domain; Region: HTH_32; pfam13565 333849002462 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 333849002463 active site 333849002464 Int/Topo IB signature motif; other site 333849002465 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 333849002466 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 333849002467 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 333849002468 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 333849002469 WHG domain; Region: WHG; pfam13305 333849002470 flavodoxin; Validated; Region: PRK07308 333849002471 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 333849002472 active site 333849002473 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 333849002474 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 333849002475 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 333849002476 Mg++ binding site [ion binding]; other site 333849002477 putative catalytic motif [active] 333849002478 substrate binding site [chemical binding]; other site 333849002479 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 333849002480 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 333849002481 Probable Catalytic site; other site 333849002482 metal-binding site 333849002483 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 333849002484 active site 333849002485 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 333849002486 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196 333849002487 Probable Catalytic site; other site 333849002488 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 333849002489 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 333849002490 substrate binding site; other site 333849002491 tetramer interface; other site 333849002492 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 333849002493 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 333849002494 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 333849002495 active site 333849002496 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 333849002497 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 333849002498 NADP binding site [chemical binding]; other site 333849002499 active site 333849002500 putative substrate binding site [chemical binding]; other site 333849002501 MULE transposase domain; Region: MULE; pfam10551 333849002502 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 333849002503 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 333849002504 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 333849002505 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 333849002506 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 333849002507 Walker A/P-loop; other site 333849002508 ATP binding site [chemical binding]; other site 333849002509 Q-loop/lid; other site 333849002510 ABC transporter signature motif; other site 333849002511 Walker B; other site 333849002512 D-loop; other site 333849002513 H-loop/switch region; other site 333849002514 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 333849002515 putative carbohydrate binding site [chemical binding]; other site 333849002516 Methyltransferase domain; Region: Methyltransf_23; pfam13489 333849002517 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 333849002518 S-adenosylmethionine binding site [chemical binding]; other site 333849002519 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 333849002520 Myxococcus xanthus RfbC like proteins are required for O-antigen biosynthesis; Region: GT2_RfbC_Mx_like; cd04184 333849002521 Probable Catalytic site; other site 333849002522 metal-binding site 333849002523 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 333849002524 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 333849002525 Probable Catalytic site; other site 333849002526 metal-binding site 333849002527 Beta-lactamase; Region: Beta-lactamase; pfam00144 333849002528 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 333849002529 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 333849002530 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 333849002531 Bacterial sugar transferase; Region: Bac_transf; pfam02397 333849002532 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 333849002533 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 333849002534 active site 333849002535 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 333849002536 This family is most closely related to the GT1 family of glycosyltransferases. capH in Staphylococcus aureus has been shown to be required for the biosynthesis of the type 1 capsular polysaccharide (CP1); Region: GT1_CapH_like; cd03812 333849002537 putative ADP-binding pocket [chemical binding]; other site 333849002538 Core-2/I-Branching enzyme; Region: Branch; pfam02485 333849002539 potential frameshift: common BLAST hit: gi|383328695|ref|YP_005354579.1| O-Antigen polymerase 333849002540 O-Antigen ligase; Region: Wzy_C; pfam04932 333849002541 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 333849002542 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 333849002543 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 333849002544 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 333849002545 Polysaccharide biosynthesis protein; Region: Polysacc_synt_2; pfam02719 333849002546 NAD(P) binding site [chemical binding]; other site 333849002547 homodimer interface [polypeptide binding]; other site 333849002548 substrate binding site [chemical binding]; other site 333849002549 active site 333849002550 N-acetylneuraminate synthase; Region: NeuB_NnaB; TIGR03569 333849002551 NeuB family; Region: NeuB; pfam03102 333849002552 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 333849002553 NeuB binding interface [polypeptide binding]; other site 333849002554 putative substrate binding site [chemical binding]; other site 333849002555 UDP-N-acetyl-D-glucosamine 2-epimerase, UDP-hydrolysing; Region: NeuC_NnaA; TIGR03568 333849002556 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 333849002557 active site 333849002558 homodimer interface [polypeptide binding]; other site 333849002559 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 333849002560 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 333849002561 putative trimer interface [polypeptide binding]; other site 333849002562 putative CoA binding site [chemical binding]; other site 333849002563 aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181 333849002564 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 333849002565 inhibitor-cofactor binding pocket; inhibition site 333849002566 pyridoxal 5'-phosphate binding site [chemical binding]; other site 333849002567 catalytic residue [active] 333849002568 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 333849002569 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 333849002570 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 333849002571 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 333849002572 ligand binding site; other site 333849002573 tetramer interface; other site 333849002574 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 333849002575 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 333849002576 NAD(P) binding site [chemical binding]; other site 333849002577 active site 333849002578 potential frameshift: common BLAST hit: gi|383329078|ref|YP_005354962.1| IS1251-like transposase 333849002579 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 333849002580 Transposase; Region: DDE_Tnp_ISL3; pfam01610 333849002581 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 333849002582 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 333849002583 Homeodomain-like domain; Region: HTH_23; pfam13384 333849002584 Transposase; Region: DDE_Tnp_ISL3; pfam01610 333849002585 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 333849002586 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 333849002587 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 333849002588 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 333849002589 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 333849002590 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 333849002591 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 333849002592 Transposase; Region: DDE_Tnp_ISL3; pfam01610 333849002593 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 333849002594 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 333849002595 Helix-turn-helix domain; Region: HTH_38; pfam13936 333849002596 Integrase core domain; Region: rve; pfam00665 333849002597 Integrase core domain; Region: rve_3; cl15866 333849002598 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 333849002599 Transposase; Region: DDE_Tnp_ISL3; pfam01610 333849002600 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 333849002601 Beta-lactamase; Region: Beta-lactamase; pfam00144 333849002602 YceG-like family; Region: YceG; pfam02618 333849002603 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 333849002604 dimerization interface [polypeptide binding]; other site 333849002605 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 333849002606 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 333849002607 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 333849002608 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 333849002609 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 333849002610 Histidine kinase; Region: HisKA_3; pfam07730 333849002611 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 333849002612 ATP binding site [chemical binding]; other site 333849002613 Mg2+ binding site [ion binding]; other site 333849002614 G-X-G motif; other site 333849002615 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 333849002616 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 333849002617 active site 333849002618 phosphorylation site [posttranslational modification] 333849002619 intermolecular recognition site; other site 333849002620 dimerization interface [polypeptide binding]; other site 333849002621 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 333849002622 DNA binding residues [nucleotide binding] 333849002623 dimerization interface [polypeptide binding]; other site 333849002624 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 333849002625 TrkA-N domain; Region: TrkA_N; pfam02254 333849002626 TrkA-C domain; Region: TrkA_C; pfam02080 333849002627 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 333849002628 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 333849002629 Phosphoglycerate Dehydrogenase, 2-hydroxyacid dehydrogenase family; Region: PGDH_1; cd12155 333849002630 putative ligand binding site [chemical binding]; other site 333849002631 NAD binding site [chemical binding]; other site 333849002632 catalytic site [active] 333849002633 Protein of unknown function (DUF1189); Region: DUF1189; pfam06691 333849002634 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 333849002635 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 333849002636 Predicted membrane protein [Function unknown]; Region: COG2246 333849002637 GtrA-like protein; Region: GtrA; pfam04138 333849002638 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 333849002639 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 333849002640 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 333849002641 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 333849002642 DNA-binding site [nucleotide binding]; DNA binding site 333849002643 RNA-binding motif; other site 333849002644 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 333849002645 TspO/MBR family; Region: TspO_MBR; pfam03073 333849002646 Chitin binding domain; Region: Chitin_bind_3; pfam03067 333849002647 TRAM domain; Region: TRAM; pfam01938 333849002648 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 333849002649 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 333849002650 S-adenosylmethionine binding site [chemical binding]; other site 333849002651 recombination regulator RecX; Provisional; Region: recX; PRK14135 333849002652 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 333849002653 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 333849002654 minor groove reading motif; other site 333849002655 helix-hairpin-helix signature motif; other site 333849002656 substrate binding pocket [chemical binding]; other site 333849002657 active site 333849002658 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 333849002659 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 333849002660 DNA binding and oxoG recognition site [nucleotide binding] 333849002661 hypothetical protein; Provisional; Region: PRK13662 333849002662 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444 333849002663 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 333849002664 Coenzyme A binding pocket [chemical binding]; other site 333849002665 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 333849002666 Domain of unknown function DUF20; Region: UPF0118; pfam01594 333849002667 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 333849002668 Domain of unknown function DUF21; Region: DUF21; pfam01595 333849002669 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 333849002670 Transporter associated domain; Region: CorC_HlyC; pfam03471 333849002671 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 333849002672 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 333849002673 G1 box; other site 333849002674 putative GEF interaction site [polypeptide binding]; other site 333849002675 GTP/Mg2+ binding site [chemical binding]; other site 333849002676 Switch I region; other site 333849002677 G2 box; other site 333849002678 G3 box; other site 333849002679 Switch II region; other site 333849002680 G4 box; other site 333849002681 G5 box; other site 333849002682 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 333849002683 Domain of unknown function (DUF1827); Region: DUF1827; pfam08860 333849002684 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 333849002685 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 333849002686 Walker A motif; other site 333849002687 ATP binding site [chemical binding]; other site 333849002688 Walker B motif; other site 333849002689 arginine finger; other site 333849002690 UvrB/uvrC motif; Region: UVR; pfam02151 333849002691 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 333849002692 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 333849002693 Walker A motif; other site 333849002694 ATP binding site [chemical binding]; other site 333849002695 Walker B motif; other site 333849002696 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 333849002697 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 333849002698 dimerization domain swap beta strand [polypeptide binding]; other site 333849002699 regulatory protein interface [polypeptide binding]; other site 333849002700 active site 333849002701 regulatory phosphorylation site [posttranslational modification]; other site 333849002702 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 333849002703 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 333849002704 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 333849002705 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 333849002706 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 333849002707 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 333849002708 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 333849002709 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 333849002710 putative ADP-binding pocket [chemical binding]; other site 333849002711 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 333849002712 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 333849002713 Protein of unknown function (DUF1797); Region: DUF1797; pfam08796 333849002714 Nuclease subunit of the excinuclease complex [DNA replication, recombination, and repair]; Region: UvrC; COG0322 333849002715 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 333849002716 GIY-YIG motif/motif A; other site 333849002717 active site 333849002718 catalytic site [active] 333849002719 putative DNA binding site [nucleotide binding]; other site 333849002720 metal binding site [ion binding]; metal-binding site 333849002721 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 333849002722 MarR family; Region: MarR_2; pfam12802 333849002723 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 333849002724 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 333849002725 dimer interface [polypeptide binding]; other site 333849002726 active site 333849002727 CoA binding pocket [chemical binding]; other site 333849002728 acyl carrier protein; Provisional; Region: acpP; PRK00982 333849002729 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 333849002730 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 333849002731 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 333849002732 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 333849002733 NAD(P) binding site [chemical binding]; other site 333849002734 active site 333849002735 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 333849002736 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 333849002737 dimer interface [polypeptide binding]; other site 333849002738 active site 333849002739 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 333849002740 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 333849002741 carboxyltransferase (CT) interaction site; other site 333849002742 biotinylation site [posttranslational modification]; other site 333849002743 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 333849002744 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 333849002745 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 333849002746 ATP-grasp domain; Region: ATP-grasp_4; cl17255 333849002747 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 333849002748 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 333849002749 Uncharacterized protein family UPF0547; Region: UPF0547; pfam10571 333849002750 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 333849002751 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 333849002752 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 333849002753 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 333849002754 active site 333849002755 motif I; other site 333849002756 motif II; other site 333849002757 GTPase YqeH; Provisional; Region: PRK13796 333849002758 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 333849002759 GTP/Mg2+ binding site [chemical binding]; other site 333849002760 G4 box; other site 333849002761 G5 box; other site 333849002762 G1 box; other site 333849002763 Switch I region; other site 333849002764 G2 box; other site 333849002765 G3 box; other site 333849002766 Switch II region; other site 333849002767 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 333849002768 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 333849002769 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 333849002770 active site 333849002771 (T/H)XGH motif; other site 333849002772 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 333849002773 Zn2+ binding site [ion binding]; other site 333849002774 Mg2+ binding site [ion binding]; other site 333849002775 Oligomerisation domain; Region: Oligomerisation; cl00519 333849002776 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 333849002777 S-adenosylmethionine binding site [chemical binding]; other site 333849002778 hypothetical protein; Provisional; Region: PRK13670 333849002779 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673 333849002780 hypothetical protein; Provisional; Region: PRK12378 333849002781 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 333849002782 Part of AAA domain; Region: AAA_19; pfam13245 333849002783 Family description; Region: UvrD_C_2; pfam13538 333849002784 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 333849002785 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 333849002786 4-oxalocrotonate tautomerase; Provisional; Region: PRK02220 333849002787 active site 1 [active] 333849002788 dimer interface [polypeptide binding]; other site 333849002789 hexamer interface [polypeptide binding]; other site 333849002790 active site 2 [active] 333849002791 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 333849002792 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 333849002793 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 333849002794 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 333849002795 active site 333849002796 dimer interface [polypeptide binding]; other site 333849002797 motif 1; other site 333849002798 motif 2; other site 333849002799 motif 3; other site 333849002800 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 333849002801 anticodon binding site; other site 333849002802 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 333849002803 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 333849002804 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 333849002805 putative active site [active] 333849002806 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 333849002807 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 333849002808 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 333849002809 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 333849002810 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 333849002811 Homeodomain-like domain; Region: HTH_23; pfam13384 333849002812 Transposase; Region: DDE_Tnp_ISL3; pfam01610 333849002813 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 333849002814 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 333849002815 active site 333849002816 motif I; other site 333849002817 motif II; other site 333849002818 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 333849002819 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 333849002820 drug efflux system protein MdtG; Provisional; Region: PRK09874 333849002821 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 333849002822 putative substrate translocation pore; other site 333849002823 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 333849002824 DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587 333849002825 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 333849002826 active site 333849002827 PHP Thumb interface [polypeptide binding]; other site 333849002828 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 333849002829 generic binding surface I; other site 333849002830 generic binding surface II; other site 333849002831 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 333849002832 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 333849002833 active site 333849002834 ADP/pyrophosphate binding site [chemical binding]; other site 333849002835 dimerization interface [polypeptide binding]; other site 333849002836 allosteric effector site; other site 333849002837 fructose-1,6-bisphosphate binding site; other site 333849002838 pyruvate kinase; Provisional; Region: PRK06354 333849002839 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 333849002840 domain interfaces; other site 333849002841 active site 333849002842 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl17700 333849002843 Transcriptional regulator [Transcription]; Region: LysR; COG0583 333849002844 The substrate binding domain of LysR-type transcriptional regulator MleR which required for malolactic fermentation, contains type 2 periplasmic binidning fold; Region: PBP2_MleR; cd08437 333849002845 putative dimerization interface [polypeptide binding]; other site 333849002846 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 333849002847 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 333849002848 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 333849002849 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 333849002850 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 333849002851 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 333849002852 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 333849002853 active site 333849002854 phosphorylation site [posttranslational modification] 333849002855 intermolecular recognition site; other site 333849002856 dimerization interface [polypeptide binding]; other site 333849002857 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 333849002858 DNA binding site [nucleotide binding] 333849002859 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 333849002860 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 333849002861 dimerization interface [polypeptide binding]; other site 333849002862 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 333849002863 dimer interface [polypeptide binding]; other site 333849002864 phosphorylation site [posttranslational modification] 333849002865 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 333849002866 ATP binding site [chemical binding]; other site 333849002867 Mg2+ binding site [ion binding]; other site 333849002868 G-X-G motif; other site 333849002869 transcriptional antiterminator BglG; Provisional; Region: PRK09772 333849002870 CAT RNA binding domain; Region: CAT_RBD; smart01061 333849002871 PRD domain; Region: PRD; pfam00874 333849002872 PRD domain; Region: PRD; pfam00874 333849002873 Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803 333849002874 putative active site [active] 333849002875 YdjC motif; other site 333849002876 Mg binding site [ion binding]; other site 333849002877 putative homodimer interface [polypeptide binding]; other site 333849002878 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 333849002879 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 333849002880 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 333849002881 active site turn [active] 333849002882 phosphorylation site [posttranslational modification] 333849002883 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 333849002884 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 333849002885 NAD(P) binding site [chemical binding]; other site 333849002886 LDH/MDH dimer interface [polypeptide binding]; other site 333849002887 substrate binding site [chemical binding]; other site 333849002888 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 333849002889 HPr interaction site; other site 333849002890 glycerol kinase (GK) interaction site [polypeptide binding]; other site 333849002891 active site 333849002892 phosphorylation site [posttranslational modification] 333849002893 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 333849002894 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 333849002895 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 333849002896 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 333849002897 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 333849002898 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 333849002899 non-specific DNA binding site [nucleotide binding]; other site 333849002900 salt bridge; other site 333849002901 sequence-specific DNA binding site [nucleotide binding]; other site 333849002902 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 333849002903 binding surface 333849002904 TPR motif; other site 333849002905 Tetratricopeptide repeat; Region: TPR_12; pfam13424 333849002906 TPR repeat; Region: TPR_11; pfam13414 333849002907 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 333849002908 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 333849002909 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 333849002910 putative L-ascorbate 6-phosphate lactonase; Provisional; Region: PRK11709 333849002911 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 333849002912 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 333849002913 active site 333849002914 phosphorylation site [posttranslational modification] 333849002915 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 333849002916 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 333849002917 active site 333849002918 P-loop; other site 333849002919 phosphorylation site [posttranslational modification] 333849002920 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 333849002921 active site 333849002922 dimer interface [polypeptide binding]; other site 333849002923 magnesium binding site [ion binding]; other site 333849002924 putative L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13210 333849002925 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 333849002926 AP (apurinic/apyrimidinic) site pocket; other site 333849002927 DNA interaction; other site 333849002928 Metal-binding active site; metal-binding site 333849002929 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 333849002930 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 333849002931 intersubunit interface [polypeptide binding]; other site 333849002932 active site 333849002933 Zn2+ binding site [ion binding]; other site 333849002934 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 333849002935 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 333849002936 Coenzyme A binding pocket [chemical binding]; other site 333849002937 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 333849002938 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 333849002939 Helix-turn-helix domain; Region: HTH_38; pfam13936 333849002940 Integrase core domain; Region: rve; pfam00665 333849002941 Integrase core domain; Region: rve_3; cl15866 333849002942 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 333849002943 HTH domain; Region: HTH_11; pfam08279 333849002944 HTH domain; Region: HTH_11; cl17392 333849002945 PRD domain; Region: PRD; pfam00874 333849002946 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 333849002947 active site 333849002948 P-loop; other site 333849002949 phosphorylation site [posttranslational modification] 333849002950 PRD domain protein EF_0829/AHA_3910; Region: EF_0829; TIGR03582 333849002951 Transposase; Region: DEDD_Tnp_IS110; pfam01548 333849002952 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 333849002953 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 333849002954 Glycine-rich SFCGS; Region: Gly_rich_SFCGS; cl11916 333849002955 conserved hypothetical protein EF_0831/AHA_3912; Region: EF_0831; TIGR03578 333849002956 conserved hypothetical protein EF_0832/AHA_3913; Region: EF_0832; TIGR03580 333849002957 Domain of unknown function (DUF4310); Region: DUF4310; pfam14187 333849002958 probable amidohydrolase EF_0837/AHA_3915; Region: EF_0837; TIGR03583 333849002959 Metallo-dependent hydrolases, subgroup B is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_B; cd01307 333849002960 active site 333849002961 uncharacterized pyridoxal phosphate-dependent enzyme; Region: selA_rel; TIGR01437 333849002962 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 333849002963 catalytic residue [active] 333849002964 conserved hypothetical protein EF_0839/AHA_3917; Region: EF_0839; TIGR03581 333849002965 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 333849002966 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 333849002967 active site 333849002968 P-loop; other site 333849002969 phosphorylation site [posttranslational modification] 333849002970 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 333849002971 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 333849002972 active site 333849002973 phosphorylation site [posttranslational modification] 333849002974 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 333849002975 HTH domain; Region: HTH_11; pfam08279 333849002976 PRD domain; Region: PRD; pfam00874 333849002977 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 333849002978 active site 333849002979 P-loop; other site 333849002980 phosphorylation site [posttranslational modification] 333849002981 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 333849002982 active site 333849002983 phosphorylation site [posttranslational modification] 333849002984 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 333849002985 Low molecular weight phosphatase family; Region: LMWPc; cd00115 333849002986 active site 333849002987 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 333849002988 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 333849002989 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 333849002990 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 333849002991 DNA binding residues [nucleotide binding] 333849002992 putative dimer interface [polypeptide binding]; other site 333849002993 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 333849002994 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 333849002995 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 333849002996 putative substrate binding site [chemical binding]; other site 333849002997 putative ATP binding site [chemical binding]; other site 333849002998 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 333849002999 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 333849003000 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 333849003001 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 333849003002 active site 333849003003 phosphorylation site [posttranslational modification] 333849003004 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 333849003005 active site 333849003006 P-loop; other site 333849003007 phosphorylation site [posttranslational modification] 333849003008 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 333849003009 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 333849003010 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 333849003011 active site 333849003012 intersubunit interface [polypeptide binding]; other site 333849003013 Zn2+ binding site [ion binding]; other site 333849003014 Predicted esterase [General function prediction only]; Region: COG0400 333849003015 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 333849003016 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 333849003017 Zn binding site [ion binding]; other site 333849003018 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 333849003019 Zn binding site [ion binding]; other site 333849003020 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 333849003021 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 333849003022 DNA-binding site [nucleotide binding]; DNA binding site 333849003023 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 333849003024 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 333849003025 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 333849003026 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 333849003027 beta-galactosidase; Region: BGL; TIGR03356 333849003028 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 333849003029 Ligand Binding Site [chemical binding]; other site 333849003030 Predicted transcriptional regulators [Transcription]; Region: COG1695 333849003031 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 333849003032 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 333849003033 putative catalytic residues [active] 333849003034 thiol/disulfide switch; other site 333849003035 ArsC family; Region: ArsC; pfam03960 333849003036 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 333849003037 dimer interface [polypeptide binding]; other site 333849003038 substrate binding site [chemical binding]; other site 333849003039 ATP binding site [chemical binding]; other site 333849003040 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 333849003041 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 333849003042 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 333849003043 putative active site [active] 333849003044 catalytic site [active] 333849003045 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 333849003046 putative active site [active] 333849003047 catalytic site [active] 333849003048 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 333849003049 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 333849003050 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 333849003051 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 333849003052 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 333849003053 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 333849003054 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 333849003055 S-adenosylmethionine binding site [chemical binding]; other site 333849003056 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 333849003057 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835 333849003058 dimer interface [polypeptide binding]; other site 333849003059 active site 333849003060 putative acyltransferase; Provisional; Region: PRK05790 333849003061 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 333849003062 dimer interface [polypeptide binding]; other site 333849003063 active site 333849003064 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 333849003065 homodimer interface [polypeptide binding]; other site 333849003066 catalytic residues [active] 333849003067 NAD binding site [chemical binding]; other site 333849003068 substrate binding pocket [chemical binding]; other site 333849003069 flexible flap; other site 333849003070 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 333849003071 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 333849003072 active site 333849003073 catalytic tetrad [active] 333849003074 37-kD nucleoid-associated bacterial protein; Region: NA37; cl15473 333849003075 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 333849003076 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 333849003077 Homeodomain-like domain; Region: HTH_23; pfam13384 333849003078 Transposase; Region: DDE_Tnp_ISL3; pfam01610 333849003079 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 333849003080 elongation factor Tu; Reviewed; Region: PRK00049 333849003081 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 333849003082 G1 box; other site 333849003083 GEF interaction site [polypeptide binding]; other site 333849003084 GTP/Mg2+ binding site [chemical binding]; other site 333849003085 Switch I region; other site 333849003086 G2 box; other site 333849003087 G3 box; other site 333849003088 Switch II region; other site 333849003089 G4 box; other site 333849003090 G5 box; other site 333849003091 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 333849003092 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 333849003093 Antibiotic Binding Site [chemical binding]; other site 333849003094 Predicted integral membrane protein [Function unknown]; Region: COG0392 333849003095 Uncharacterized conserved protein [Function unknown]; Region: COG2898 333849003096 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 333849003097 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 333849003098 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 333849003099 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 333849003100 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 333849003101 N-acetyl-D-glucosamine binding site [chemical binding]; other site 333849003102 catalytic residue [active] 333849003103 Domain of unknown function (DUF368); Region: DUF368; cl00893 333849003104 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 333849003105 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 333849003106 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 333849003107 motif II; other site 333849003108 DNA primase; Validated; Region: dnaG; PRK05667 333849003109 CHC2 zinc finger; Region: zf-CHC2; pfam01807 333849003110 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 333849003111 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 333849003112 active site 333849003113 metal binding site [ion binding]; metal-binding site 333849003114 interdomain interaction site; other site 333849003115 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 333849003116 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 333849003117 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 333849003118 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 333849003119 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 333849003120 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 333849003121 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 333849003122 DNA binding residues [nucleotide binding] 333849003123 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 333849003124 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 333849003125 S1 domain; Region: S1_2; pfam13509 333849003126 ferric uptake regulator; Provisional; Region: fur; PRK09462 333849003127 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 333849003128 metal binding site 2 [ion binding]; metal-binding site 333849003129 putative DNA binding helix; other site 333849003130 metal binding site 1 [ion binding]; metal-binding site 333849003131 dimer interface [polypeptide binding]; other site 333849003132 structural Zn2+ binding site [ion binding]; other site 333849003133 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 333849003134 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 333849003135 active site 333849003136 Int/Topo IB signature motif; other site 333849003137 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 333849003138 segregation and condensation protein B; Reviewed; Region: scpB; PRK00135 333849003139 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 333849003140 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 333849003141 RNA binding surface [nucleotide binding]; other site 333849003142 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 333849003143 active site 333849003144 Predicted membrane protein [Function unknown]; Region: COG3601 333849003145 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 333849003146 Predicted membrane protein [Function unknown]; Region: COG1288 333849003147 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 333849003148 hypothetical protein; Provisional; Region: PRK07205 333849003149 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 333849003150 active site 333849003151 metal binding site [ion binding]; metal-binding site 333849003152 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 333849003153 4Fe-4S single cluster domain; Region: Fer4_13; pfam13370 333849003154 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 333849003155 ATP-dependent DNA helicase, RecQ family; Region: recQ_fam; TIGR00614 333849003156 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 333849003157 ATP binding site [chemical binding]; other site 333849003158 putative Mg++ binding site [ion binding]; other site 333849003159 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 333849003160 nucleotide binding region [chemical binding]; other site 333849003161 ATP-binding site [chemical binding]; other site 333849003162 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 333849003163 cytidylate kinase; Provisional; Region: cmk; PRK00023 333849003164 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 333849003165 CMP-binding site; other site 333849003166 The sites determining sugar specificity; other site 333849003167 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 333849003168 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 333849003169 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 333849003170 RNA binding site [nucleotide binding]; other site 333849003171 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 333849003172 RNA binding site [nucleotide binding]; other site 333849003173 GTP-binding protein Der; Reviewed; Region: PRK00093 333849003174 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 333849003175 G1 box; other site 333849003176 GTP/Mg2+ binding site [chemical binding]; other site 333849003177 Switch I region; other site 333849003178 G2 box; other site 333849003179 Switch II region; other site 333849003180 G3 box; other site 333849003181 G4 box; other site 333849003182 G5 box; other site 333849003183 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 333849003184 G1 box; other site 333849003185 GTP/Mg2+ binding site [chemical binding]; other site 333849003186 Switch I region; other site 333849003187 G2 box; other site 333849003188 G3 box; other site 333849003189 Switch II region; other site 333849003190 G4 box; other site 333849003191 G5 box; other site 333849003192 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 333849003193 IHF dimer interface [polypeptide binding]; other site 333849003194 IHF - DNA interface [nucleotide binding]; other site 333849003195 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 333849003196 TPR motif; other site 333849003197 binding surface 333849003198 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 333849003199 binding surface 333849003200 TPR motif; other site 333849003201 hypothetical protein; Provisional; Region: PRK03636 333849003202 UPF0302 domain; Region: UPF0302; pfam08864 333849003203 IDEAL domain; Region: IDEAL; pfam08858 333849003204 Uncharacterized conserved protein [Function unknown]; Region: COG1284 333849003205 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 333849003206 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 333849003207 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531 333849003208 homodimer interface [polypeptide binding]; other site 333849003209 metal binding site [ion binding]; metal-binding site 333849003210 potential frameshift: common BLAST hit: gi|383328518|ref|YP_005354402.1| tRNA nucleotidyltransferase/poly(A) polymerase family protein 333849003211 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 333849003212 active site 333849003213 NTP binding site [chemical binding]; other site 333849003214 metal binding triad [ion binding]; metal-binding site 333849003215 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 333849003216 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 333849003217 acyl-CoA synthetase; Provisional; Region: PTZ00216 333849003218 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 333849003219 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 333849003220 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 333849003221 Walker A/P-loop; other site 333849003222 ATP binding site [chemical binding]; other site 333849003223 Q-loop/lid; other site 333849003224 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 333849003225 ABC transporter signature motif; other site 333849003226 Walker B; other site 333849003227 D-loop; other site 333849003228 ABC transporter; Region: ABC_tran_2; pfam12848 333849003229 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 333849003230 thymidylate synthase; Region: thym_sym; TIGR03284 333849003231 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 333849003232 dimerization interface [polypeptide binding]; other site 333849003233 active site 333849003234 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 333849003235 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 333849003236 folate binding site [chemical binding]; other site 333849003237 NADP+ binding site [chemical binding]; other site 333849003238 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 333849003239 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 333849003240 EDD domain protein, DegV family; Region: DegV; TIGR00762 333849003241 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 333849003242 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 333849003243 active site 333849003244 catalytic triad [active] 333849003245 oxyanion hole [active] 333849003246 Uncharacterized protein conserved in bacteria (DUF2140); Region: DUF2140; pfam09911 333849003247 methionine sulfoxide reductase A; Provisional; Region: PRK14054 333849003248 hypothetical protein; Provisional; Region: PRK13672 333849003249 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 333849003250 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462 333849003251 Catalytic site [active] 333849003252 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465 333849003253 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 333849003254 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 333849003255 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 333849003256 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 333849003257 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 333849003258 GTP/Mg2+ binding site [chemical binding]; other site 333849003259 G4 box; other site 333849003260 G5 box; other site 333849003261 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 333849003262 G1 box; other site 333849003263 G1 box; other site 333849003264 GTP/Mg2+ binding site [chemical binding]; other site 333849003265 Switch I region; other site 333849003266 G2 box; other site 333849003267 G2 box; other site 333849003268 G3 box; other site 333849003269 G3 box; other site 333849003270 Switch II region; other site 333849003271 Switch II region; other site 333849003272 RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner; Region: RNase_H; cl14782 333849003273 active site 333849003274 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 333849003275 RNA/DNA hybrid binding site [nucleotide binding]; other site 333849003276 active site 333849003277 DNA protecting protein DprA; Region: dprA; TIGR00732 333849003278 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 333849003279 DNA topoisomerase I; Validated; Region: PRK05582 333849003280 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 333849003281 active site 333849003282 interdomain interaction site; other site 333849003283 putative metal-binding site [ion binding]; other site 333849003284 nucleotide binding site [chemical binding]; other site 333849003285 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 333849003286 domain I; other site 333849003287 DNA binding groove [nucleotide binding] 333849003288 phosphate binding site [ion binding]; other site 333849003289 domain II; other site 333849003290 domain III; other site 333849003291 nucleotide binding site [chemical binding]; other site 333849003292 catalytic site [active] 333849003293 domain IV; other site 333849003294 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 333849003295 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 333849003296 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 333849003297 Glucose inhibited division protein A; Region: GIDA; pfam01134 333849003298 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 333849003299 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 333849003300 active site 333849003301 Int/Topo IB signature motif; other site 333849003302 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 333849003303 active site 333849003304 HslU subunit interaction site [polypeptide binding]; other site 333849003305 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 333849003306 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 333849003307 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 333849003308 Walker A motif; other site 333849003309 ATP binding site [chemical binding]; other site 333849003310 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 333849003311 Walker B motif; other site 333849003312 arginine finger; other site 333849003313 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 333849003314 transcriptional repressor CodY; Validated; Region: PRK04158 333849003315 CodY GAF-like domain; Region: CodY; pfam06018 333849003316 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 333849003317 putative DNA binding site [nucleotide binding]; other site 333849003318 putative Zn2+ binding site [ion binding]; other site 333849003319 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 333849003320 active site 333849003321 catalytic residues [active] 333849003322 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 333849003323 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 333849003324 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 333849003325 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 333849003326 ATP binding site [chemical binding]; other site 333849003327 Mg2+ binding site [ion binding]; other site 333849003328 G-X-G motif; other site 333849003329 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 333849003330 anchoring element; other site 333849003331 dimer interface [polypeptide binding]; other site 333849003332 ATP binding site [chemical binding]; other site 333849003333 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 333849003334 active site 333849003335 putative metal-binding site [ion binding]; other site 333849003336 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 333849003337 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 333849003338 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 333849003339 CAP-like domain; other site 333849003340 active site 333849003341 primary dimer interface [polypeptide binding]; other site 333849003342 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 333849003343 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 333849003344 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 333849003345 Pyruvate formate lyase 1; Region: PFL1; cd01678 333849003346 coenzyme A binding site [chemical binding]; other site 333849003347 active site 333849003348 catalytic residues [active] 333849003349 glycine loop; other site 333849003350 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 333849003351 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 333849003352 FeS/SAM binding site; other site 333849003353 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 333849003354 DHH family; Region: DHH; pfam01368 333849003355 DHHA2 domain; Region: DHHA2; pfam02833 333849003356 Domain of unknown function (DUF1803); Region: DUF1803; pfam08820 333849003357 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 333849003358 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 333849003359 hypothetical protein; Provisional; Region: PRK04164 333849003360 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 333849003361 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 333849003362 Transcriptional regulators [Transcription]; Region: PurR; COG1609 333849003363 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 333849003364 DNA binding site [nucleotide binding] 333849003365 domain linker motif; other site 333849003366 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 333849003367 ligand binding site [chemical binding]; other site 333849003368 dimerization interface [polypeptide binding]; other site 333849003369 Uncharacterized conserved protein [Function unknown]; Region: COG1284 333849003370 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 333849003371 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 333849003372 dimer interface [polypeptide binding]; other site 333849003373 conserved gate region; other site 333849003374 ABC-ATPase subunit interface; other site 333849003375 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 333849003376 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 333849003377 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 333849003378 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 333849003379 Walker A/P-loop; other site 333849003380 ATP binding site [chemical binding]; other site 333849003381 Q-loop/lid; other site 333849003382 ABC transporter signature motif; other site 333849003383 Walker B; other site 333849003384 D-loop; other site 333849003385 H-loop/switch region; other site 333849003386 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 333849003387 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 333849003388 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 333849003389 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 333849003390 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 333849003391 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 333849003392 dimer interface [polypeptide binding]; other site 333849003393 conserved gate region; other site 333849003394 putative PBP binding loops; other site 333849003395 ABC-ATPase subunit interface; other site 333849003396 NMT1/THI5 like; Region: NMT1; pfam09084 333849003397 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 333849003398 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 333849003399 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 333849003400 Walker A/P-loop; other site 333849003401 ATP binding site [chemical binding]; other site 333849003402 Q-loop/lid; other site 333849003403 ABC transporter signature motif; other site 333849003404 Walker B; other site 333849003405 D-loop; other site 333849003406 H-loop/switch region; other site 333849003407 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 333849003408 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 333849003409 active site 333849003410 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 333849003411 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 333849003412 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 333849003413 Transposase, Mutator family; Region: Transposase_mut; pfam00872 333849003414 MULE transposase domain; Region: MULE; pfam10551 333849003415 aminotransferase AlaT; Validated; Region: PRK09265 333849003416 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 333849003417 pyridoxal 5'-phosphate binding site [chemical binding]; other site 333849003418 homodimer interface [polypeptide binding]; other site 333849003419 catalytic residue [active] 333849003420 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 333849003421 non-specific DNA binding site [nucleotide binding]; other site 333849003422 salt bridge; other site 333849003423 sequence-specific DNA binding site [nucleotide binding]; other site 333849003424 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 333849003425 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 333849003426 active site 333849003427 dimer interface [polypeptide binding]; other site 333849003428 Membrane transport protein; Region: Mem_trans; cl09117 333849003429 (R)-2-Hydroxyglutarate Dehydrogenase and related dehydrogenases, NAD-binding and catalytic domains; Region: HGDH_like; cd12184 333849003430 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 333849003431 putative homodimer interface [polypeptide binding]; other site 333849003432 putative ligand binding site [chemical binding]; other site 333849003433 putative NAD binding site [chemical binding]; other site 333849003434 catalytic site [active] 333849003435 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 333849003436 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 333849003437 active site 333849003438 phosphorylation site [posttranslational modification] 333849003439 intermolecular recognition site; other site 333849003440 dimerization interface [polypeptide binding]; other site 333849003441 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 333849003442 ATP binding site [chemical binding]; other site 333849003443 Mg2+ binding site [ion binding]; other site 333849003444 G-X-G motif; other site 333849003445 sensory histidine kinase DcuS; Provisional; Region: PRK11086 333849003446 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 333849003447 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 333849003448 prohibitin homologues; Region: PHB; smart00244 333849003449 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 333849003450 Predicted membrane protein [Function unknown]; Region: COG4129 333849003451 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 333849003452 Predicted membrane protein [Function unknown]; Region: COG4129 333849003453 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 333849003454 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 333849003455 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 333849003456 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 333849003457 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 333849003458 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 333849003459 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 333849003460 Class I aldolases; Region: Aldolase_Class_I; cl17187 333849003461 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 333849003462 phosphate binding site [ion binding]; other site 333849003463 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 333849003464 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 333849003465 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 333849003466 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 333849003467 dimer interface [polypeptide binding]; other site 333849003468 conserved gate region; other site 333849003469 putative PBP binding loops; other site 333849003470 ABC-ATPase subunit interface; other site 333849003471 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 333849003472 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 333849003473 dimer interface [polypeptide binding]; other site 333849003474 conserved gate region; other site 333849003475 putative PBP binding loops; other site 333849003476 ABC-ATPase subunit interface; other site 333849003477 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 333849003478 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 333849003479 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 333849003480 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 333849003481 active site 333849003482 xanthine permease; Region: pbuX; TIGR03173 333849003483 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 333849003484 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 333849003485 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 333849003486 NAD binding site [chemical binding]; other site 333849003487 ATP-grasp domain; Region: ATP-grasp; pfam02222 333849003488 adenylosuccinate lyase; Provisional; Region: PRK07492 333849003489 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 333849003490 tetramer interface [polypeptide binding]; other site 333849003491 active site 333849003492 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 333849003493 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 333849003494 ATP binding site [chemical binding]; other site 333849003495 active site 333849003496 substrate binding site [chemical binding]; other site 333849003497 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700 333849003498 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 333849003499 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 333849003500 putative active site [active] 333849003501 catalytic triad [active] 333849003502 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 333849003503 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 333849003504 dimerization interface [polypeptide binding]; other site 333849003505 ATP binding site [chemical binding]; other site 333849003506 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 333849003507 dimerization interface [polypeptide binding]; other site 333849003508 ATP binding site [chemical binding]; other site 333849003509 amidophosphoribosyltransferase; Provisional; Region: PRK07272 333849003510 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 333849003511 active site 333849003512 tetramer interface [polypeptide binding]; other site 333849003513 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 333849003514 active site 333849003515 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 333849003516 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 333849003517 dimerization interface [polypeptide binding]; other site 333849003518 putative ATP binding site [chemical binding]; other site 333849003519 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 333849003520 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 333849003521 active site 333849003522 substrate binding site [chemical binding]; other site 333849003523 cosubstrate binding site; other site 333849003524 catalytic site [active] 333849003525 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 333849003526 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 333849003527 purine monophosphate binding site [chemical binding]; other site 333849003528 dimer interface [polypeptide binding]; other site 333849003529 putative catalytic residues [active] 333849003530 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 333849003531 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 333849003532 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 333849003533 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 333849003534 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 333849003535 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 333849003536 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 333849003537 active site 333849003538 catalytic tetrad [active] 333849003539 Response regulator receiver domain; Region: Response_reg; pfam00072 333849003540 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 333849003541 active site 333849003542 phosphorylation site [posttranslational modification] 333849003543 intermolecular recognition site; other site 333849003544 dimerization interface [polypeptide binding]; other site 333849003545 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 333849003546 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 333849003547 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 333849003548 Histidine kinase; Region: His_kinase; pfam06580 333849003549 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 333849003550 ATP binding site [chemical binding]; other site 333849003551 Mg2+ binding site [ion binding]; other site 333849003552 G-X-G motif; other site 333849003553 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 333849003554 Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309 333849003555 putative ligand binding site [chemical binding]; other site 333849003556 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 333849003557 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 333849003558 putative ligand binding site [chemical binding]; other site 333849003559 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 333849003560 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 333849003561 Walker A/P-loop; other site 333849003562 ATP binding site [chemical binding]; other site 333849003563 Q-loop/lid; other site 333849003564 ABC transporter signature motif; other site 333849003565 Walker B; other site 333849003566 D-loop; other site 333849003567 H-loop/switch region; other site 333849003568 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 333849003569 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 333849003570 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 333849003571 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 333849003572 TM-ABC transporter signature motif; other site 333849003573 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 333849003574 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 333849003575 active site 333849003576 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 333849003577 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 333849003578 DNA-binding site [nucleotide binding]; DNA binding site 333849003579 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 333849003580 pyridoxal 5'-phosphate binding site [chemical binding]; other site 333849003581 homodimer interface [polypeptide binding]; other site 333849003582 catalytic residue [active] 333849003583 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 333849003584 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 333849003585 tetramer interface [polypeptide binding]; other site 333849003586 TPP-binding site [chemical binding]; other site 333849003587 heterodimer interface [polypeptide binding]; other site 333849003588 phosphorylation loop region [posttranslational modification] 333849003589 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 333849003590 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 333849003591 alpha subunit interface [polypeptide binding]; other site 333849003592 TPP binding site [chemical binding]; other site 333849003593 heterodimer interface [polypeptide binding]; other site 333849003594 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 333849003595 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 333849003596 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 333849003597 E3 interaction surface; other site 333849003598 lipoyl attachment site [posttranslational modification]; other site 333849003599 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 333849003600 E3 interaction surface; other site 333849003601 lipoyl attachment site [posttranslational modification]; other site 333849003602 e3 binding domain; Region: E3_binding; pfam02817 333849003603 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 333849003604 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 333849003605 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 333849003606 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 333849003607 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 333849003608 hypothetical protein; Provisional; Region: PRK04387 333849003609 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 333849003610 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 333849003611 active site 333849003612 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 333849003613 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 333849003614 G1 box; other site 333849003615 putative GEF interaction site [polypeptide binding]; other site 333849003616 GTP/Mg2+ binding site [chemical binding]; other site 333849003617 Switch I region; other site 333849003618 G2 box; other site 333849003619 G3 box; other site 333849003620 Switch II region; other site 333849003621 G4 box; other site 333849003622 G5 box; other site 333849003623 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 333849003624 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 333849003625 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 333849003626 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 333849003627 ATP binding site [chemical binding]; other site 333849003628 putative Mg++ binding site [ion binding]; other site 333849003629 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 333849003630 nucleotide binding region [chemical binding]; other site 333849003631 ATP-binding site [chemical binding]; other site 333849003632 RQC domain; Region: RQC; pfam09382 333849003633 HRDC domain; Region: HRDC; pfam00570 333849003634 Protein of unknown function (DUF1507); Region: DUF1507; pfam07408 333849003635 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 333849003636 pyruvate carboxylase; Reviewed; Region: PRK12999 333849003637 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 333849003638 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 333849003639 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 333849003640 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 333849003641 active site 333849003642 catalytic residues [active] 333849003643 metal binding site [ion binding]; metal-binding site 333849003644 homodimer binding site [polypeptide binding]; other site 333849003645 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 333849003646 carboxyltransferase (CT) interaction site; other site 333849003647 biotinylation site [posttranslational modification]; other site 333849003648 Protein of unknown function (DUF964); Region: DUF964; pfam06133 333849003649 Uncharacterized protein conserved in bacteria (DUF2129); Region: DUF2129; pfam09902 333849003650 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 333849003651 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 333849003652 S-adenosylmethionine binding site [chemical binding]; other site 333849003653 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 333849003654 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 333849003655 active site 333849003656 (T/H)XGH motif; other site 333849003657 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 333849003658 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 333849003659 protein binding site [polypeptide binding]; other site 333849003660 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 333849003661 SLBB domain; Region: SLBB; pfam10531 333849003662 comEA protein; Region: comE; TIGR01259 333849003663 Helix-hairpin-helix motif; Region: HHH; pfam00633 333849003664 GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472 333849003665 oxyanion hole [active] 333849003666 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 333849003667 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 333849003668 catalytic motif [active] 333849003669 Zn binding site [ion binding]; other site 333849003670 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 333849003671 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 333849003672 Competence protein; Region: Competence; pfam03772 333849003673 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 333849003674 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 333849003675 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 333849003676 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 333849003677 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 333849003678 Protein of unknown function (DUF441); Region: DUF441; pfam04284 333849003679 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 333849003680 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 333849003681 Soluble P-type ATPase [General function prediction only]; Region: COG4087 333849003682 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 333849003683 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 333849003684 catalytic core [active] 333849003685 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 333849003686 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 333849003687 DEAD/DEAH box helicase; Region: DEAD; pfam00270 333849003688 DEAD_2; Region: DEAD_2; pfam06733 333849003689 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 333849003690 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 333849003691 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 333849003692 Uncharacterized conserved protein [Function unknown]; Region: COG1284 333849003693 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 333849003694 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 333849003695 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 333849003696 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 333849003697 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 333849003698 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 333849003699 Coenzyme A binding pocket [chemical binding]; other site 333849003700 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 333849003701 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 333849003702 Ligand Binding Site [chemical binding]; other site 333849003703 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 333849003704 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 333849003705 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 333849003706 putative active site [active] 333849003707 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 333849003708 dimer interface [polypeptide binding]; other site 333849003709 FMN binding site [chemical binding]; other site 333849003710 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 333849003711 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 333849003712 putative substrate translocation pore; other site 333849003713 POT family; Region: PTR2; cl17359 333849003714 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 333849003715 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 333849003716 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 333849003717 Part of AAA domain; Region: AAA_19; pfam13245 333849003718 Family description; Region: UvrD_C_2; pfam13538 333849003719 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 333849003720 Predicted transcriptional regulators [Transcription]; Region: COG1733 333849003721 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 333849003722 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 333849003723 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 333849003724 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 333849003725 dimer interface [polypeptide binding]; other site 333849003726 motif 1; other site 333849003727 active site 333849003728 motif 2; other site 333849003729 motif 3; other site 333849003730 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 333849003731 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 333849003732 putative tRNA-binding site [nucleotide binding]; other site 333849003733 B3/4 domain; Region: B3_4; pfam03483 333849003734 tRNA synthetase B5 domain; Region: B5; smart00874 333849003735 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 333849003736 dimer interface [polypeptide binding]; other site 333849003737 motif 1; other site 333849003738 motif 3; other site 333849003739 motif 2; other site 333849003740 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 333849003741 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 333849003742 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 333849003743 active site 333849003744 HIGH motif; other site 333849003745 dimer interface [polypeptide binding]; other site 333849003746 KMSKS motif; other site 333849003747 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 333849003748 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 333849003749 Walker A/P-loop; other site 333849003750 ATP binding site [chemical binding]; other site 333849003751 Q-loop/lid; other site 333849003752 ABC transporter signature motif; other site 333849003753 Walker B; other site 333849003754 D-loop; other site 333849003755 H-loop/switch region; other site 333849003756 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 333849003757 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 333849003758 substrate binding pocket [chemical binding]; other site 333849003759 membrane-bound complex binding site; other site 333849003760 hinge residues; other site 333849003761 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 333849003762 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 333849003763 dimer interface [polypeptide binding]; other site 333849003764 conserved gate region; other site 333849003765 putative PBP binding loops; other site 333849003766 ABC-ATPase subunit interface; other site 333849003767 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 333849003768 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 333849003769 dimer interface [polypeptide binding]; other site 333849003770 conserved gate region; other site 333849003771 putative PBP binding loops; other site 333849003772 ABC-ATPase subunit interface; other site 333849003773 glutamate racemase; Provisional; Region: PRK00865 333849003774 ribonuclease PH; Reviewed; Region: rph; PRK00173 333849003775 Ribonuclease PH; Region: RNase_PH_bact; cd11362 333849003776 hexamer interface [polypeptide binding]; other site 333849003777 active site 333849003778 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 333849003779 active site 333849003780 dimerization interface [polypeptide binding]; other site 333849003781 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 333849003782 active site 333849003783 metal binding site [ion binding]; metal-binding site 333849003784 homotetramer interface [polypeptide binding]; other site 333849003785 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 333849003786 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 333849003787 Mechanosensitive ion channel; Region: MS_channel; pfam00924 333849003788 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 333849003789 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 333849003790 homodimer interface [polypeptide binding]; other site 333849003791 substrate-cofactor binding pocket; other site 333849003792 catalytic residue [active] 333849003793 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK06079 333849003794 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 333849003795 NAD binding site [chemical binding]; other site 333849003796 homotetramer interface [polypeptide binding]; other site 333849003797 homodimer interface [polypeptide binding]; other site 333849003798 substrate binding site [chemical binding]; other site 333849003799 active site 333849003800 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 333849003801 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 333849003802 active site 333849003803 Uncharacterized conserved protein [Function unknown]; Region: COG3589 333849003804 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 333849003805 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 333849003806 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 333849003807 Eukaryotic protein of unknown function (DUF829); Region: DUF829; pfam05705 333849003808 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 333849003809 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 333849003810 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 333849003811 Obg family GTPase CgtA; Region: Obg_CgtA; TIGR02729 333849003812 GTP1/OBG; Region: GTP1_OBG; pfam01018 333849003813 Obg GTPase; Region: Obg; cd01898 333849003814 G1 box; other site 333849003815 GTP/Mg2+ binding site [chemical binding]; other site 333849003816 Switch I region; other site 333849003817 G2 box; other site 333849003818 G3 box; other site 333849003819 Switch II region; other site 333849003820 G4 box; other site 333849003821 G5 box; other site 333849003822 ribonuclease Z; Region: RNase_Z; TIGR02651 333849003823 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 333849003824 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 333849003825 NAD(P) binding site [chemical binding]; other site 333849003826 active site 333849003827 Protein of unknown function (DUF1049); Region: DUF1049; cl01539 333849003828 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 333849003829 DHH family; Region: DHH; pfam01368 333849003830 DHHA1 domain; Region: DHHA1; pfam02272 333849003831 Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; pfam10141 333849003832 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 333849003833 active site 333849003834 LexA repressor; Validated; Region: PRK00215 333849003835 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 333849003836 putative DNA binding site [nucleotide binding]; other site 333849003837 putative Zn2+ binding site [ion binding]; other site 333849003838 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 333849003839 Catalytic site [active] 333849003840 Bacterial protein of unknown function (DUF896); Region: DUF896; cl01722 333849003841 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 333849003842 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 333849003843 TPP-binding site [chemical binding]; other site 333849003844 dimer interface [polypeptide binding]; other site 333849003845 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 333849003846 PYR/PP interface [polypeptide binding]; other site 333849003847 dimer interface [polypeptide binding]; other site 333849003848 TPP binding site [chemical binding]; other site 333849003849 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 333849003850 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 333849003851 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 333849003852 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 333849003853 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 333849003854 dimer interface [polypeptide binding]; other site 333849003855 pyridoxal 5'-phosphate binding site [chemical binding]; other site 333849003856 catalytic residue [active] 333849003857 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 333849003858 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 333849003859 metal binding site 2 [ion binding]; metal-binding site 333849003860 putative DNA binding helix; other site 333849003861 metal binding site 1 [ion binding]; metal-binding site 333849003862 dimer interface [polypeptide binding]; other site 333849003863 structural Zn2+ binding site [ion binding]; other site 333849003864 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 333849003865 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 333849003866 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 333849003867 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 333849003868 MarR family; Region: MarR; pfam01047 333849003869 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 333849003870 Major Facilitator Superfamily; Region: MFS_1; pfam07690 333849003871 putative substrate translocation pore; other site 333849003872 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 333849003873 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 333849003874 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 333849003875 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 333849003876 minor groove reading motif; other site 333849003877 helix-hairpin-helix signature motif; other site 333849003878 substrate binding pocket [chemical binding]; other site 333849003879 active site 333849003880 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 333849003881 Transglycosylase; Region: Transgly; pfam00912 333849003882 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 333849003883 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 333849003884 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 333849003885 Protein of unknown function (DUF1273); Region: DUF1273; cl01859 333849003886 cell division protein GpsB; Provisional; Region: PRK14127 333849003887 DivIVA domain; Region: DivI1A_domain; TIGR03544 333849003888 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 333849003889 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 333849003890 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 333849003891 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 333849003892 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 333849003893 active site 333849003894 Zn binding site [ion binding]; other site 333849003895 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 333849003896 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 333849003897 Zn2+ binding site [ion binding]; other site 333849003898 Mg2+ binding site [ion binding]; other site 333849003899 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 333849003900 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 333849003901 substrate-cofactor binding pocket; other site 333849003902 pyridoxal 5'-phosphate binding site [chemical binding]; other site 333849003903 catalytic residue [active] 333849003904 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 333849003905 L-threonine dehydrogenase, extended (e) SDRs; Region: TDH_SDR_e; cd05272 333849003906 NAD binding site [chemical binding]; other site 333849003907 homodimer interface [polypeptide binding]; other site 333849003908 active site 333849003909 putative substrate binding site [chemical binding]; other site 333849003910 putative fructoselysine transporter; Provisional; Region: frlA; PRK11357 333849003911 VanZ like family; Region: VanZ; pfam04892 333849003912 RDD family; Region: RDD; pfam06271 333849003913 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 333849003914 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 333849003915 ATP binding site [chemical binding]; other site 333849003916 Mg++ binding site [ion binding]; other site 333849003917 motif III; other site 333849003918 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 333849003919 nucleotide binding region [chemical binding]; other site 333849003920 ATP-binding site [chemical binding]; other site 333849003921 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 333849003922 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 333849003923 Coenzyme A binding pocket [chemical binding]; other site 333849003924 T-box leader; HMPREF0351_nc10014 333849003925 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 333849003926 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 333849003927 motif 1; other site 333849003928 active site 333849003929 motif 2; other site 333849003930 motif 3; other site 333849003931 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 333849003932 DHHA1 domain; Region: DHHA1; pfam02272 333849003933 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 333849003934 Predicted membrane protein [Function unknown]; Region: COG4684 333849003935 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 333849003936 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 333849003937 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 333849003938 RNA/DNA hybrid binding site [nucleotide binding]; other site 333849003939 active site 333849003940 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 333849003941 DNA-binding site [nucleotide binding]; DNA binding site 333849003942 RNA-binding motif; other site 333849003943 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 333849003944 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 333849003945 Potassium binding sites [ion binding]; other site 333849003946 Cesium cation binding sites [ion binding]; other site 333849003947 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 333849003948 lipoprotein signal peptidase; Provisional; Region: PRK14797 333849003949 lipoprotein signal peptidase; Provisional; Region: PRK14787 333849003950 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 333849003951 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 333849003952 RNA binding surface [nucleotide binding]; other site 333849003953 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 333849003954 active site 333849003955 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 333849003956 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 333849003957 active site 333849003958 uracil transporter; Provisional; Region: PRK10720 333849003959 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 333849003960 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 333849003961 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 333849003962 dihydroorotase; Validated; Region: pyrC; PRK09357 333849003963 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 333849003964 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 333849003965 active site 333849003966 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 333849003967 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 333849003968 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 333849003969 catalytic site [active] 333849003970 subunit interface [polypeptide binding]; other site 333849003971 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 333849003972 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 333849003973 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 333849003974 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 333849003975 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 333849003976 ATP-grasp domain; Region: ATP-grasp_4; cl17255 333849003977 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 333849003978 IMP binding site; other site 333849003979 dimer interface [polypeptide binding]; other site 333849003980 interdomain contacts; other site 333849003981 partial ornithine binding site; other site 333849003982 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 333849003983 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 333849003984 FAD binding pocket [chemical binding]; other site 333849003985 FAD binding motif [chemical binding]; other site 333849003986 phosphate binding motif [ion binding]; other site 333849003987 beta-alpha-beta structure motif; other site 333849003988 NAD binding pocket [chemical binding]; other site 333849003989 Iron coordination center [ion binding]; other site 333849003990 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 333849003991 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 333849003992 heterodimer interface [polypeptide binding]; other site 333849003993 active site 333849003994 FMN binding site [chemical binding]; other site 333849003995 homodimer interface [polypeptide binding]; other site 333849003996 substrate binding site [chemical binding]; other site 333849003997 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 333849003998 active site 333849003999 dimer interface [polypeptide binding]; other site 333849004000 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 333849004001 active site 333849004002 HD domain; Region: HD_3; cl17350 333849004003 Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124 333849004004 active site 333849004005 zinc binding site [ion binding]; other site 333849004006 Transcriptional regulator [Transcription]; Region: LysR; COG0583 333849004007 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 333849004008 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 333849004009 dimerization interface [polypeptide binding]; other site 333849004010 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 333849004011 Domain of unknown function (DUF814); Region: DUF814; pfam05670 333849004012 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 333849004013 Helix-turn-helix domain; Region: HTH_38; pfam13936 333849004014 Integrase core domain; Region: rve; pfam00665 333849004015 Integrase core domain; Region: rve_3; cl15866 333849004016 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 333849004017 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 333849004018 zinc binding site [ion binding]; other site 333849004019 putative ligand binding site [chemical binding]; other site 333849004020 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 333849004021 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 333849004022 TM-ABC transporter signature motif; other site 333849004023 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 333849004024 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 333849004025 Walker A/P-loop; other site 333849004026 ATP binding site [chemical binding]; other site 333849004027 Q-loop/lid; other site 333849004028 ABC transporter signature motif; other site 333849004029 Walker B; other site 333849004030 D-loop; other site 333849004031 H-loop/switch region; other site 333849004032 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 333849004033 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 333849004034 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 333849004035 shikimate binding site; other site 333849004036 NAD(P) binding site [chemical binding]; other site 333849004037 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816 333849004038 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 333849004039 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 333849004040 dimer interface [polypeptide binding]; other site 333849004041 DNA topoisomerase III; Provisional; Region: PRK07726 333849004042 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 333849004043 active site 333849004044 putative interdomain interaction site [polypeptide binding]; other site 333849004045 putative metal-binding site [ion binding]; other site 333849004046 putative nucleotide binding site [chemical binding]; other site 333849004047 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 333849004048 domain I; other site 333849004049 DNA binding groove [nucleotide binding] 333849004050 phosphate binding site [ion binding]; other site 333849004051 domain II; other site 333849004052 domain III; other site 333849004053 nucleotide binding site [chemical binding]; other site 333849004054 catalytic site [active] 333849004055 domain IV; other site 333849004056 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 333849004057 putative addiction module antidote; Region: doc_partner; TIGR02609 333849004058 Fic/DOC family; Region: Fic; cl00960 333849004059 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 333849004060 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 333849004061 tetramer (dimer of dimers) interface [polypeptide binding]; other site 333849004062 NAD binding site [chemical binding]; other site 333849004063 dimer interface [polypeptide binding]; other site 333849004064 substrate binding site [chemical binding]; other site 333849004065 Cupin domain; Region: Cupin_2; cl17218 333849004066 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 333849004067 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 333849004068 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 333849004069 Major Facilitator Superfamily; Region: MFS_1; pfam07690 333849004070 putative substrate translocation pore; other site 333849004071 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 333849004072 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 333849004073 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 333849004074 active site 333849004075 P-loop; other site 333849004076 phosphorylation site [posttranslational modification] 333849004077 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 333849004078 PRD domain; Region: PRD; pfam00874 333849004079 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 333849004080 active site 333849004081 P-loop; other site 333849004082 phosphorylation site [posttranslational modification] 333849004083 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 333849004084 active site 333849004085 phosphorylation site [posttranslational modification] 333849004086 putative oxidoreductase; Provisional; Region: PRK10206 333849004087 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 333849004088 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 333849004089 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 333849004090 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 333849004091 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 333849004092 putative active site [active] 333849004093 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 333849004094 active site 333849004095 catalytic site [active] 333849004096 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 333849004097 Cna protein B-type domain; Region: Cna_B; pfam05738 333849004098 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 333849004099 Cna protein B-type domain; Region: Cna_B; pfam05738 333849004100 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 333849004101 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 333849004102 metal ion-dependent adhesion site (MIDAS); other site 333849004103 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 333849004104 domain interaction interfaces [polypeptide binding]; other site 333849004105 Cna protein B-type domain; Region: Cna_B; pfam05738 333849004106 Cna protein B-type domain; Region: Cna_B; pfam05738 333849004107 HTH domain; Region: HTH_11; pfam08279 333849004108 Mga helix-turn-helix domain; Region: Mga; pfam05043 333849004109 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 333849004110 active site 333849004111 P-loop; other site 333849004112 phosphorylation site [posttranslational modification] 333849004113 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 333849004114 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 333849004115 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 333849004116 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 333849004117 Walker A/P-loop; other site 333849004118 ATP binding site [chemical binding]; other site 333849004119 Q-loop/lid; other site 333849004120 ABC transporter signature motif; other site 333849004121 Walker B; other site 333849004122 D-loop; other site 333849004123 H-loop/switch region; other site 333849004124 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 333849004125 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 333849004126 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 333849004127 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 333849004128 active site 333849004129 phosphorylation site [posttranslational modification] 333849004130 intermolecular recognition site; other site 333849004131 dimerization interface [polypeptide binding]; other site 333849004132 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 333849004133 DNA binding site [nucleotide binding] 333849004134 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 333849004135 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 333849004136 dimer interface [polypeptide binding]; other site 333849004137 phosphorylation site [posttranslational modification] 333849004138 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 333849004139 ATP binding site [chemical binding]; other site 333849004140 Mg2+ binding site [ion binding]; other site 333849004141 G-X-G motif; other site 333849004142 Heat induced stress protein YflT; Region: YflT; pfam11181 333849004143 Domain of unknown function (DUF2382); Region: DUF2382; pfam09557 333849004144 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 333849004145 active site 333849004146 Int/Topo IB signature motif; other site 333849004147 DNA binding site [nucleotide binding] 333849004148 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 333849004149 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 333849004150 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 333849004151 acyl-activating enzyme (AAE) consensus motif; other site 333849004152 acyl-activating enzyme (AAE) consensus motif; other site 333849004153 AMP binding site [chemical binding]; other site 333849004154 active site 333849004155 CoA binding site [chemical binding]; other site 333849004156 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 333849004157 dimer interface [polypeptide binding]; other site 333849004158 substrate binding site [chemical binding]; other site 333849004159 ATP binding site [chemical binding]; other site 333849004160 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; pfam07155 333849004161 Protein of unknown function (DUF436); Region: DUF436; pfam04260 333849004162 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 333849004163 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 333849004164 Ca binding site [ion binding]; other site 333849004165 active site 333849004166 catalytic site [active] 333849004167 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 333849004168 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 333849004169 metal ion-dependent adhesion site (MIDAS); other site 333849004170 EDD domain protein, DegV family; Region: DegV; TIGR00762 333849004171 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 333849004172 stage V sporulation protein B; Region: spore_V_B; TIGR02900 333849004173 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 333849004174 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 333849004175 AzlC protein; Region: AzlC; pfam03591 333849004176 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 333849004177 Cation efflux family; Region: Cation_efflux; pfam01545 333849004178 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 333849004179 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4868 333849004180 Domain of unknown function (DUF1846); Region: DUF1846; pfam08903 333849004181 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 333849004182 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 333849004183 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 333849004184 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 333849004185 Guanylate kinase; Region: Guanylate_kin; pfam00625 333849004186 active site 333849004187 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 333849004188 Coenzyme A binding pocket [chemical binding]; other site 333849004189 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 333849004190 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 333849004191 putative PBP binding loops; other site 333849004192 dimer interface [polypeptide binding]; other site 333849004193 ABC-ATPase subunit interface; other site 333849004194 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 333849004195 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 333849004196 substrate binding pocket [chemical binding]; other site 333849004197 membrane-bound complex binding site; other site 333849004198 hinge residues; other site 333849004199 amidase; Provisional; Region: PRK06529 333849004200 Amidase; Region: Amidase; cl11426 333849004201 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 333849004202 Dihydroorotate dehydrogenase (DHOD) class 1A FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1A_like; cd04741 333849004203 active site 333849004204 FMN binding site [chemical binding]; other site 333849004205 substrate binding site [chemical binding]; other site 333849004206 catalytic residues [active] 333849004207 homodimer interface [polypeptide binding]; other site 333849004208 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 333849004209 Predicted membrane protein [Function unknown]; Region: COG3212 333849004210 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 333849004211 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 333849004212 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 333849004213 S-adenosylmethionine binding site [chemical binding]; other site 333849004214 Predicted integral membrane protein [Function unknown]; Region: COG5521 333849004215 Predicted integral membrane protein [Function unknown]; Region: COG5521 333849004216 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 333849004217 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 333849004218 dimer interface [polypeptide binding]; other site 333849004219 conserved gate region; other site 333849004220 putative PBP binding loops; other site 333849004221 ABC-ATPase subunit interface; other site 333849004222 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 333849004223 dimer interface [polypeptide binding]; other site 333849004224 conserved gate region; other site 333849004225 putative PBP binding loops; other site 333849004226 ABC-ATPase subunit interface; other site 333849004227 maltose ABC transporter periplasmic protein; Reviewed; Region: malE; PRK09474 333849004228 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 333849004229 maltodextrin glucosidase; Provisional; Region: PRK10785 333849004230 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 333849004231 homodimer interface [polypeptide binding]; other site 333849004232 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 333849004233 active site 333849004234 homodimer interface [polypeptide binding]; other site 333849004235 catalytic site [active] 333849004236 Uncharacterized conserved protein [Function unknown]; Region: COG1284 333849004237 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 333849004238 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 333849004239 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 333849004240 active site 333849004241 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 333849004242 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 333849004243 MarR family; Region: MarR; pfam01047 333849004244 Domain of unknown function DUF20; Region: UPF0118; pfam01594 333849004245 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 333849004246 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 333849004247 Mga helix-turn-helix domain; Region: Mga; pfam05043 333849004248 mannonate dehydratase; Provisional; Region: PRK03906 333849004249 mannonate dehydratase; Region: uxuA; TIGR00695 333849004250 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 333849004251 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 333849004252 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 333849004253 DNA-binding transcriptional repressor UxuR; Provisional; Region: PRK10225 333849004254 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 333849004255 DNA-binding site [nucleotide binding]; DNA binding site 333849004256 FCD domain; Region: FCD; pfam07729 333849004257 peroxiredoxin; Region: AhpC; TIGR03137 333849004258 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 333849004259 dimer interface [polypeptide binding]; other site 333849004260 decamer (pentamer of dimers) interface [polypeptide binding]; other site 333849004261 catalytic triad [active] 333849004262 peroxidatic and resolving cysteines [active] 333849004263 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 333849004264 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 333849004265 catalytic residue [active] 333849004266 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 333849004267 catalytic residues [active] 333849004268 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 333849004269 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 333849004270 Uncharacterized protein conserved in bacteria (DUF2200); Region: DUF2200; pfam09966 333849004271 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 333849004272 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 333849004273 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 333849004274 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 333849004275 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 333849004276 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 333849004277 Transposase, Mutator family; Region: Transposase_mut; pfam00872 333849004278 MULE transposase domain; Region: MULE; pfam10551 333849004279 Transcriptional regulator [Transcription]; Region: LytR; COG1316 333849004280 Cell cycle protein; Region: FTSW_RODA_SPOVE; pfam01098 333849004281 ykoK leader; HMPREF0351_nc10016 333849004282 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 333849004283 Helix-turn-helix domain; Region: HTH_38; pfam13936 333849004284 Integrase core domain; Region: rve; pfam00665 333849004285 Integrase core domain; Region: rve_3; cl15866 333849004286 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 333849004287 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 333849004288 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 333849004289 putative active site cavity [active] 333849004290 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 333849004291 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK12315 333849004292 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 333849004293 TPP-binding site; other site 333849004294 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 333849004295 PYR/PP interface [polypeptide binding]; other site 333849004296 dimer interface [polypeptide binding]; other site 333849004297 TPP binding site [chemical binding]; other site 333849004298 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 333849004299 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 333849004300 Helix-turn-helix domain; Region: HTH_38; pfam13936 333849004301 Integrase core domain; Region: rve; pfam00665 333849004302 Integrase core domain; Region: rve_3; cl15866 333849004303 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 333849004304 glutaminase A; Region: Gln_ase; TIGR03814 333849004305 glutamate:gamma-aminobutyrate antiporter; Region: 2A0307_GadC; TIGR00910 333849004306 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 333849004307 Predicted membrane protein [Function unknown]; Region: COG2261 333849004308 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 333849004309 Protein of unknown function (DUF3036); Region: DUF3036; pfam11234 333849004310 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 333849004311 sequence-specific DNA binding site [nucleotide binding]; other site 333849004312 salt bridge; other site 333849004313 Predicted membrane protein [Function unknown]; Region: COG2261 333849004314 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 333849004315 Small integral membrane protein (DUF2273); Region: DUF2273; pfam10031 333849004316 oxidoreductase; Provisional; Region: PRK07985 333849004317 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 333849004318 NAD(P) binding site [chemical binding]; other site 333849004319 active site 333849004320 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 333849004321 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 333849004322 Cl binding site [ion binding]; other site 333849004323 oligomer interface [polypeptide binding]; other site 333849004324 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 333849004325 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 333849004326 Ligand binding site; other site 333849004327 metal-binding site 333849004328 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 333849004329 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 333849004330 Ligand binding site; other site 333849004331 metal-binding site 333849004332 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 333849004333 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 333849004334 active site 333849004335 motif I; other site 333849004336 motif II; other site 333849004337 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 333849004338 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 333849004339 catalytic triad [active] 333849004340 conserved cis-peptide bond; other site 333849004341 conserved hypothetical protein; Region: TIGR02328 333849004342 Pyrimidine dimer DNA glycosylase; Region: Pyr_excise; pfam03013 333849004343 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 333849004344 DNA-binding site [nucleotide binding]; DNA binding site 333849004345 RNA-binding motif; other site 333849004346 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 333849004347 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 333849004348 motif II; other site 333849004349 mannonate dehydratase; Provisional; Region: PRK03906 333849004350 mannonate dehydratase; Region: uxuA; TIGR00695 333849004351 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 333849004352 active pocket/dimerization site; other site 333849004353 active site 333849004354 phosphorylation site [posttranslational modification] 333849004355 PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830 333849004356 active site 333849004357 phosphorylation site [posttranslational modification] 333849004358 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 333849004359 PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609 333849004360 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 333849004361 active site 333849004362 NAD binding site [chemical binding]; other site 333849004363 metal binding site [ion binding]; metal-binding site 333849004364 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 333849004365 Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_12; cd12177 333849004366 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 333849004367 putative ligand binding site [chemical binding]; other site 333849004368 putative NAD binding site [chemical binding]; other site 333849004369 catalytic site [active] 333849004370 Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023 333849004371 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 333849004372 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 333849004373 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 333849004374 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 333849004375 putative active site [active] 333849004376 Protein of unknown function (DUF3955); Region: DUF3955; pfam13127 333849004377 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 333849004378 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 333849004379 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 333849004380 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 333849004381 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 333849004382 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 333849004383 Isochorismatase family; Region: Isochorismatase; pfam00857 333849004384 catalytic triad [active] 333849004385 conserved cis-peptide bond; other site 333849004386 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 333849004387 ArsC family; Region: ArsC; pfam03960 333849004388 putative catalytic residues [active] 333849004389 thiol/disulfide switch; other site 333849004390 Mga helix-turn-helix domain; Region: Mga; pfam05043 333849004391 CAAX protease self-immunity; Region: Abi; pfam02517 333849004392 foldase protein PrsA; Reviewed; Region: prsA; PRK01326 333849004393 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 333849004394 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 333849004395 active site 333849004396 intersubunit interactions; other site 333849004397 catalytic residue [active] 333849004398 PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; pfam03829 333849004399 Transposase; Region: DEDD_Tnp_IS110; pfam01548 333849004400 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 333849004401 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 333849004402 PTS system, glucitol/sorbitol-specific, IIBC component; Region: EIIBC-GUT; TIGR00825 333849004403 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 333849004404 Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663 333849004405 PTS system enzyme II sorbitol-specific factor; Region: EII-GUT; pfam03608 333849004406 Glucitol operon activator protein (GutM); Region: GutM; pfam06923 333849004407 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 333849004408 HTH domain; Region: HTH_11; pfam08279 333849004409 PRD domain; Region: PRD; pfam00874 333849004410 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 333849004411 active site 333849004412 P-loop; other site 333849004413 phosphorylation site [posttranslational modification] 333849004414 Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2; Region: PTS_EIIA_2; pfam00359 333849004415 active site 333849004416 phosphorylation site [posttranslational modification] 333849004417 sorbitol-6-phosphate 2-dehydrogenase; Provisional; Region: PRK06171 333849004418 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 333849004419 NAD(P) binding site [chemical binding]; other site 333849004420 active site 333849004421 Domain of unknown function (DUF378); Region: DUF378; pfam04070 333849004422 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 333849004423 Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471 333849004424 putative dimer interface [polypeptide binding]; other site 333849004425 Transposase, Mutator family; Region: Transposase_mut; pfam00872 333849004426 MULE transposase domain; Region: MULE; pfam10551 333849004427 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 333849004428 Helix-turn-helix domain; Region: HTH_38; pfam13936 333849004429 Integrase core domain; Region: rve; pfam00665 333849004430 Integrase core domain; Region: rve_3; cl15866 333849004431 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 333849004432 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 333849004433 Int/Topo IB signature motif; other site 333849004434 GTP-binding protein LepA; Provisional; Region: PRK05433 333849004435 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 333849004436 G1 box; other site 333849004437 putative GEF interaction site [polypeptide binding]; other site 333849004438 GTP/Mg2+ binding site [chemical binding]; other site 333849004439 Switch I region; other site 333849004440 G2 box; other site 333849004441 G3 box; other site 333849004442 Switch II region; other site 333849004443 G4 box; other site 333849004444 G5 box; other site 333849004445 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 333849004446 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 333849004447 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 333849004448 Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527 333849004449 Sterol carrier protein domain; Region: SCP2_2; pfam13530 333849004450 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014 333849004451 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 333849004452 Clp amino terminal domain; Region: Clp_N; pfam02861 333849004453 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 333849004454 Walker A motif; other site 333849004455 ATP binding site [chemical binding]; other site 333849004456 Walker B motif; other site 333849004457 arginine finger; other site 333849004458 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 333849004459 Walker A motif; other site 333849004460 ATP binding site [chemical binding]; other site 333849004461 Walker B motif; other site 333849004462 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 333849004463 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 333849004464 Protein of unknown function (DUF1294); Region: DUF1294; pfam06961 333849004465 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 333849004466 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 333849004467 peptidase T; Region: peptidase-T; TIGR01882 333849004468 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 333849004469 metal binding site [ion binding]; metal-binding site 333849004470 dimer interface [polypeptide binding]; other site 333849004471 Uncharacterized conserved protein [Function unknown]; Region: COG0327 333849004472 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 333849004473 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 333849004474 Uncharacterized conserved protein [Function unknown]; Region: COG0327 333849004475 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 333849004476 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 333849004477 Family of unknown function (DUF633); Region: DUF633; pfam04816 333849004478 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 333849004479 primosomal protein DnaI; Reviewed; Region: PRK08939 333849004480 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 333849004481 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 333849004482 Walker A motif; other site 333849004483 ATP binding site [chemical binding]; other site 333849004484 Walker B motif; other site 333849004485 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 333849004486 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 333849004487 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 333849004488 ATP cone domain; Region: ATP-cone; pfam03477 333849004489 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 333849004490 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 333849004491 CoA-binding site [chemical binding]; other site 333849004492 ATP-binding [chemical binding]; other site 333849004493 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 333849004494 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 333849004495 DNA binding site [nucleotide binding] 333849004496 catalytic residue [active] 333849004497 H2TH interface [polypeptide binding]; other site 333849004498 putative catalytic residues [active] 333849004499 turnover-facilitating residue; other site 333849004500 intercalation triad [nucleotide binding]; other site 333849004501 8OG recognition residue [nucleotide binding]; other site 333849004502 putative reading head residues; other site 333849004503 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 333849004504 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 333849004505 DNA polymerase I; Provisional; Region: PRK05755 333849004506 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 333849004507 active site 333849004508 metal binding site 1 [ion binding]; metal-binding site 333849004509 putative 5' ssDNA interaction site; other site 333849004510 metal binding site 3; metal-binding site 333849004511 metal binding site 2 [ion binding]; metal-binding site 333849004512 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 333849004513 putative DNA binding site [nucleotide binding]; other site 333849004514 putative metal binding site [ion binding]; other site 333849004515 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 333849004516 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 333849004517 active site 333849004518 DNA binding site [nucleotide binding] 333849004519 catalytic site [active] 333849004520 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 333849004521 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 333849004522 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 333849004523 active site 2 [active] 333849004524 active site 1 [active] 333849004525 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 333849004526 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 333849004527 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 333849004528 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 333849004529 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 333849004530 putative active site [active] 333849004531 hypothetical protein; Provisional; Region: PRK04351 333849004532 SprT homologues; Region: SprT; cl01182 333849004533 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 333849004534 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 333849004535 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 333849004536 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 333849004537 RNA binding site [nucleotide binding]; other site 333849004538 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 333849004539 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 333849004540 active site 333849004541 metal binding site [ion binding]; metal-binding site 333849004542 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 333849004543 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 333849004544 active site residue [active] 333849004545 Protein of unknown function (DUF3650); Region: DUF3650; pfam12368 333849004546 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 333849004547 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 333849004548 active site 333849004549 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 333849004550 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 333849004551 Protein of unknown function (DUF1149); Region: DUF1149; cl11551 333849004552 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 333849004553 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 333849004554 motif II; other site 333849004555 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 333849004556 catalytic core [active] 333849004557 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 333849004558 Transcription elongation factor Elf1 like; Region: Elf1; cl02038 333849004559 Nitrogen regulatory protein P-II; Region: P-II; smart00938 333849004560 Protein of unknown function (DUF1538); Region: DUF1538; pfam07556 333849004561 Protein of unknown function (DUF1538); Region: DUF1538; pfam07556 333849004562 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 333849004563 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 333849004564 dimer interface [polypeptide binding]; other site 333849004565 conserved gate region; other site 333849004566 putative PBP binding loops; other site 333849004567 ABC-ATPase subunit interface; other site 333849004568 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 333849004569 dimer interface [polypeptide binding]; other site 333849004570 conserved gate region; other site 333849004571 putative PBP binding loops; other site 333849004572 ABC-ATPase subunit interface; other site 333849004573 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 333849004574 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 333849004575 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 333849004576 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 333849004577 active site 333849004578 phosphorylation site [posttranslational modification] 333849004579 intermolecular recognition site; other site 333849004580 dimerization interface [polypeptide binding]; other site 333849004581 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 333849004582 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 333849004583 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 333849004584 Histidine kinase; Region: His_kinase; pfam06580 333849004585 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 333849004586 ATP binding site [chemical binding]; other site 333849004587 Mg2+ binding site [ion binding]; other site 333849004588 G-X-G motif; other site 333849004589 prephenate dehydratase; Provisional; Region: PRK11898 333849004590 Prephenate dehydratase; Region: PDT; pfam00800 333849004591 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 333849004592 putative L-Phe binding site [chemical binding]; other site 333849004593 shikimate kinase; Reviewed; Region: aroK; PRK00131 333849004594 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 333849004595 ADP binding site [chemical binding]; other site 333849004596 magnesium binding site [ion binding]; other site 333849004597 putative shikimate binding site; other site 333849004598 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 333849004599 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 333849004600 hinge; other site 333849004601 active site 333849004602 prephenate dehydrogenase; Validated; Region: PRK06545 333849004603 prephenate dehydrogenase; Validated; Region: PRK08507 333849004604 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 333849004605 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 333849004606 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 333849004607 Tetramer interface [polypeptide binding]; other site 333849004608 active site 333849004609 FMN-binding site [chemical binding]; other site 333849004610 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 333849004611 active site 333849004612 dimer interface [polypeptide binding]; other site 333849004613 metal binding site [ion binding]; metal-binding site 333849004614 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 333849004615 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 333849004616 Beta galactosidase small chain; Region: Bgal_small_N; pfam02929 333849004617 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 333849004618 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 333849004619 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 333849004620 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 333849004621 Melibiase; Region: Melibiase; pfam02065 333849004622 potential frameshift: common BLAST hit: gi|383328904|ref|YP_005354788.1| LacI family transcriptional regulator 333849004623 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 333849004624 DNA binding site [nucleotide binding] 333849004625 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 333849004626 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 333849004627 Transcriptional regulators [Transcription]; Region: PurR; COG1609 333849004628 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 333849004629 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 333849004630 TRAM domain; Region: TRAM; cl01282 333849004631 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 333849004632 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 333849004633 S-adenosylmethionine binding site [chemical binding]; other site 333849004634 putative lipid kinase; Reviewed; Region: PRK13055 333849004635 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 333849004636 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 333849004637 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 333849004638 GatB domain; Region: GatB_Yqey; smart00845 333849004639 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 333849004640 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 333849004641 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 333849004642 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 333849004643 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 333849004644 nucleotide binding pocket [chemical binding]; other site 333849004645 K-X-D-G motif; other site 333849004646 catalytic site [active] 333849004647 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 333849004648 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 333849004649 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 333849004650 Dimer interface [polypeptide binding]; other site 333849004651 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 333849004652 Part of AAA domain; Region: AAA_19; pfam13245 333849004653 Family description; Region: UvrD_C_2; pfam13538 333849004654 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 333849004655 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 333849004656 Cl- selectivity filter; other site 333849004657 Cl- binding residues [ion binding]; other site 333849004658 pore gating glutamate residue; other site 333849004659 dimer interface [polypeptide binding]; other site 333849004660 H+/Cl- coupling transport residue; other site 333849004661 TrkA-C domain; Region: TrkA_C; pfam02080 333849004662 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 333849004663 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 333849004664 active site 333849004665 phosphorylation site [posttranslational modification] 333849004666 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 333849004667 active site 333849004668 P-loop; other site 333849004669 phosphorylation site [posttranslational modification] 333849004670 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 333849004671 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 333849004672 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 333849004673 putative substrate binding site [chemical binding]; other site 333849004674 putative ATP binding site [chemical binding]; other site 333849004675 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 333849004676 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 333849004677 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 333849004678 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 333849004679 G1 box; other site 333849004680 GTP/Mg2+ binding site [chemical binding]; other site 333849004681 Switch I region; other site 333849004682 G2 box; other site 333849004683 G3 box; other site 333849004684 Switch II region; other site 333849004685 G4 box; other site 333849004686 G5 box; other site 333849004687 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 333849004688 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 333849004689 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 333849004690 Walker A motif; other site 333849004691 ATP binding site [chemical binding]; other site 333849004692 Walker B motif; other site 333849004693 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 333849004694 trigger factor; Provisional; Region: tig; PRK01490 333849004695 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 333849004696 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 333849004697 RDD family; Region: RDD; pfam06271 333849004698 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 333849004699 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 333849004700 tandem repeat interface [polypeptide binding]; other site 333849004701 oligomer interface [polypeptide binding]; other site 333849004702 active site residues [active] 333849004703 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 333849004704 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 333849004705 glutaminase active site [active] 333849004706 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 333849004707 dimer interface [polypeptide binding]; other site 333849004708 active site 333849004709 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 333849004710 dimer interface [polypeptide binding]; other site 333849004711 active site 333849004712 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 333849004713 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 333849004714 active site 333849004715 substrate binding site [chemical binding]; other site 333849004716 metal binding site [ion binding]; metal-binding site 333849004717 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 333849004718 YbbR-like protein; Region: YbbR; pfam07949 333849004719 Uncharacterized conserved protein [Function unknown]; Region: COG1624 333849004720 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 333849004721 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 333849004722 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 333849004723 dimer interface [polypeptide binding]; other site 333849004724 PYR/PP interface [polypeptide binding]; other site 333849004725 TPP binding site [chemical binding]; other site 333849004726 substrate binding site [chemical binding]; other site 333849004727 Sen15 protein; Region: Sen15; cl09847 333849004728 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 333849004729 Domain of unknown function; Region: EKR; pfam10371 333849004730 4Fe-4S binding domain; Region: Fer4_6; pfam12837 333849004731 4Fe-4S binding domain; Region: Fer4; pfam00037 333849004732 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 333849004733 TPP-binding site [chemical binding]; other site 333849004734 dimer interface [polypeptide binding]; other site 333849004735 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 333849004736 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 333849004737 catalytic residues [active] 333849004738 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 333849004739 Helix-turn-helix domain; Region: HTH_38; pfam13936 333849004740 Integrase core domain; Region: rve; pfam00665 333849004741 Integrase core domain; Region: rve_3; cl15866 333849004742 tandem five-transmembrane protein; Region: Gpos_tandem_5TM; TIGR01218 333849004743 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 333849004744 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 333849004745 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 333849004746 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 333849004747 phosphate binding site [ion binding]; other site 333849004748 putative substrate binding pocket [chemical binding]; other site 333849004749 dimer interface [polypeptide binding]; other site 333849004750 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 333849004751 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 333849004752 aspartate racemase; Region: asp_race; TIGR00035 333849004753 Predicted ATP-grasp enzyme [General function prediction only]; Region: COG3919 333849004754 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 333849004755 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 333849004756 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 333849004757 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 333849004758 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 333849004759 excinuclease ABC subunit B; Provisional; Region: PRK05298 333849004760 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 333849004761 ATP binding site [chemical binding]; other site 333849004762 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 333849004763 nucleotide binding region [chemical binding]; other site 333849004764 ATP-binding site [chemical binding]; other site 333849004765 Ultra-violet resistance protein B; Region: UvrB; pfam12344 333849004766 UvrB/uvrC motif; Region: UVR; pfam02151 333849004767 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 333849004768 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 333849004769 substrate binding pocket [chemical binding]; other site 333849004770 membrane-bound complex binding site; other site 333849004771 hinge residues; other site 333849004772 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 333849004773 dimer interface [polypeptide binding]; other site 333849004774 conserved gate region; other site 333849004775 ABC-ATPase subunit interface; other site 333849004776 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 333849004777 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 333849004778 Walker A/P-loop; other site 333849004779 ATP binding site [chemical binding]; other site 333849004780 Q-loop/lid; other site 333849004781 ABC transporter signature motif; other site 333849004782 Walker B; other site 333849004783 D-loop; other site 333849004784 H-loop/switch region; other site 333849004785 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 333849004786 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 333849004787 chaperone protein DnaJ; Provisional; Region: PRK14276 333849004788 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 333849004789 HSP70 interaction site [polypeptide binding]; other site 333849004790 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 333849004791 substrate binding site [polypeptide binding]; other site 333849004792 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 333849004793 Zn binding sites [ion binding]; other site 333849004794 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 333849004795 substrate binding site [polypeptide binding]; other site 333849004796 dimer interface [polypeptide binding]; other site 333849004797 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 333849004798 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 333849004799 nucleotide binding site [chemical binding]; other site 333849004800 NEF interaction site [polypeptide binding]; other site 333849004801 SBD interface [polypeptide binding]; other site 333849004802 potential frameshift: common BLAST hit: gi|383329016|ref|YP_005354900.1| co-chaperone GrpE 333849004803 GrpE; Region: GrpE; pfam01025 333849004804 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 333849004805 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 333849004806 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 333849004807 dimer interface [polypeptide binding]; other site 333849004808 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 333849004809 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 333849004810 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 333849004811 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 333849004812 FeS/SAM binding site; other site 333849004813 HemN C-terminal domain; Region: HemN_C; pfam06969 333849004814 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_3; cd03140 333849004815 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 333849004816 conserved cys residue [active] 333849004817 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 333849004818 putative dimer interface [polypeptide binding]; other site 333849004819 catalytic triad [active] 333849004820 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 333849004821 putative deacylase active site [active] 333849004822 Domain of unknown function (DU1801); Region: DUF1801; cl17490 333849004823 Helix-turn-helix domain; Region: HTH_17; pfam12728 333849004824 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 333849004825 Sugar transport protein; Region: Sugar_transport; pfam06800 333849004826 glucose-1-dehydrogenase; Provisional; Region: PRK08936 333849004827 glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358 333849004828 NAD binding site [chemical binding]; other site 333849004829 homodimer interface [polypeptide binding]; other site 333849004830 active site 333849004831 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 333849004832 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 333849004833 active site 333849004834 Riboflavin kinase; Region: Flavokinase; pfam01687 333849004835 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01550 333849004836 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 333849004837 RNA binding site [nucleotide binding]; other site 333849004838 active site 333849004839 XFP C-terminal domain; Region: XFP_C; pfam09363 333849004840 putative phosphoketolase; Provisional; Region: PRK05261 333849004841 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 333849004842 TPP-binding site; other site 333849004843 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 333849004844 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 333849004845 translation initiation factor IF-2; Region: IF-2; TIGR00487 333849004846 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 333849004847 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 333849004848 G1 box; other site 333849004849 putative GEF interaction site [polypeptide binding]; other site 333849004850 GTP/Mg2+ binding site [chemical binding]; other site 333849004851 Switch I region; other site 333849004852 G2 box; other site 333849004853 G3 box; other site 333849004854 Switch II region; other site 333849004855 G4 box; other site 333849004856 G5 box; other site 333849004857 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 333849004858 Translation-initiation factor 2; Region: IF-2; pfam11987 333849004859 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 333849004860 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 333849004861 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 333849004862 putative RNA binding cleft [nucleotide binding]; other site 333849004863 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 333849004864 NusA N-terminal domain; Region: NusA_N; pfam08529 333849004865 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 333849004866 RNA binding site [nucleotide binding]; other site 333849004867 homodimer interface [polypeptide binding]; other site 333849004868 NusA-like KH domain; Region: KH_5; pfam13184 333849004869 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 333849004870 G-X-X-G motif; other site 333849004871 ribosome maturation protein RimP; Reviewed; Region: PRK00092 333849004872 Sm and related proteins; Region: Sm_like; cl00259 333849004873 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 333849004874 putative oligomer interface [polypeptide binding]; other site 333849004875 putative RNA binding site [nucleotide binding]; other site 333849004876 DNA polymerase III PolC; Validated; Region: polC; PRK00448 333849004877 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 333849004878 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 333849004879 generic binding surface II; other site 333849004880 generic binding surface I; other site 333849004881 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 333849004882 active site 333849004883 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 333849004884 active site 333849004885 catalytic site [active] 333849004886 substrate binding site [chemical binding]; other site 333849004887 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 333849004888 prolyl-tRNA synthetase; Provisional; Region: PRK09194 333849004889 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 333849004890 dimer interface [polypeptide binding]; other site 333849004891 motif 1; other site 333849004892 active site 333849004893 motif 2; other site 333849004894 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 333849004895 putative deacylase active site [active] 333849004896 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 333849004897 active site 333849004898 motif 3; other site 333849004899 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 333849004900 anticodon binding site; other site 333849004901 RIP metalloprotease RseP; Region: TIGR00054 333849004902 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 333849004903 active site 333849004904 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 333849004905 protein binding site [polypeptide binding]; other site 333849004906 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 333849004907 putative substrate binding region [chemical binding]; other site 333849004908 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 333849004909 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 333849004910 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 333849004911 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 333849004912 catalytic residue [active] 333849004913 putative FPP diphosphate binding site; other site 333849004914 putative FPP binding hydrophobic cleft; other site 333849004915 dimer interface [polypeptide binding]; other site 333849004916 putative IPP diphosphate binding site; other site 333849004917 ribosome recycling factor; Reviewed; Region: frr; PRK00083 333849004918 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 333849004919 hinge region; other site 333849004920 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 333849004921 putative nucleotide binding site [chemical binding]; other site 333849004922 uridine monophosphate binding site [chemical binding]; other site 333849004923 homohexameric interface [polypeptide binding]; other site 333849004924 elongation factor Ts; Provisional; Region: tsf; PRK09377 333849004925 UBA/TS-N domain; Region: UBA; pfam00627 333849004926 Elongation factor TS; Region: EF_TS; pfam00889 333849004927 Elongation factor TS; Region: EF_TS; pfam00889 333849004928 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 333849004929 rRNA interaction site [nucleotide binding]; other site 333849004930 S8 interaction site; other site 333849004931 putative laminin-1 binding site; other site 333849004932 Arginine repressor [Transcription]; Region: ArgR; COG1438 333849004933 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 333849004934 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 333849004935 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 333849004936 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 333849004937 catalytic residue [active] 333849004938 phosphonoacetaldehyde hydrolase; Provisional; Region: PRK13478 333849004939 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 333849004940 motif II; other site 333849004941 arginyl-tRNA synthetase; Reviewed; Region: PRK12451 333849004942 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 333849004943 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 333849004944 active site 333849004945 HIGH motif; other site 333849004946 KMSK motif region; other site 333849004947 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 333849004948 tRNA binding surface [nucleotide binding]; other site 333849004949 anticodon binding site; other site 333849004950 carbamate kinase; Reviewed; Region: PRK12686 333849004951 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 333849004952 putative substrate binding site [chemical binding]; other site 333849004953 nucleotide binding site [chemical binding]; other site 333849004954 nucleotide binding site [chemical binding]; other site 333849004955 homodimer interface [polypeptide binding]; other site 333849004956 ornithine carbamoyltransferase; Validated; Region: PRK02102 333849004957 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 333849004958 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 333849004959 arginine deiminase; Provisional; Region: PRK01388 333849004960 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 333849004961 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 333849004962 ligand binding site [chemical binding]; other site 333849004963 flexible hinge region; other site 333849004964 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 333849004965 UGMP family protein; Validated; Region: PRK09604 333849004966 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 333849004967 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 333849004968 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 333849004969 Coenzyme A binding pocket [chemical binding]; other site 333849004970 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 333849004971 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 333849004972 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 333849004973 Coenzyme A binding pocket [chemical binding]; other site 333849004974 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 333849004975 Glycoprotease family; Region: Peptidase_M22; pfam00814 333849004976 Transcriptional regulators [Transcription]; Region: PurR; COG1609 333849004977 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 333849004978 DNA binding site [nucleotide binding] 333849004979 domain linker motif; other site 333849004980 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 333849004981 putative dimerization interface [polypeptide binding]; other site 333849004982 putative ligand binding site [chemical binding]; other site 333849004983 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 333849004984 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 333849004985 Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744 333849004986 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 333849004987 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 333849004988 NAD binding site [chemical binding]; other site 333849004989 homodimer interface [polypeptide binding]; other site 333849004990 active site 333849004991 substrate binding site [chemical binding]; other site 333849004992 Protein of unknown function (DUF3042); Region: DUF3042; pfam11240 333849004993 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 333849004994 Uncharacterized conserved protein [Function unknown]; Region: COG3189 333849004995 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 333849004996 active site residue [active] 333849004997 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 333849004998 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 333849004999 nucleotide binding site [chemical binding]; other site 333849005000 Glucokinase; Region: Glucokinase; cl17310 333849005001 Bacterial protein of unknown function (DUF910); Region: DUF910; pfam06014 333849005002 Rhomboid family; Region: Rhomboid; pfam01694 333849005003 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 333849005004 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 333849005005 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 333849005006 ABC-ATPase subunit interface; other site 333849005007 dimer interface [polypeptide binding]; other site 333849005008 putative PBP binding regions; other site 333849005009 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 333849005010 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 333849005011 ABC-ATPase subunit interface; other site 333849005012 dimer interface [polypeptide binding]; other site 333849005013 putative PBP binding regions; other site 333849005014 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 333849005015 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 333849005016 Walker A/P-loop; other site 333849005017 ATP binding site [chemical binding]; other site 333849005018 Q-loop/lid; other site 333849005019 ABC transporter signature motif; other site 333849005020 Walker B; other site 333849005021 D-loop; other site 333849005022 H-loop/switch region; other site 333849005023 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 333849005024 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 333849005025 intersubunit interface [polypeptide binding]; other site 333849005026 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 333849005027 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 333849005028 folate binding site [chemical binding]; other site 333849005029 NADP+ binding site [chemical binding]; other site 333849005030 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 333849005031 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4876 333849005032 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 333849005033 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 333849005034 active site 333849005035 dimer interface [polypeptide binding]; other site 333849005036 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 333849005037 Ligand Binding Site [chemical binding]; other site 333849005038 Molecular Tunnel; other site 333849005039 Transposase domain (DUF772); Region: DUF772; pfam05598 333849005040 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 333849005041 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 333849005042 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 333849005043 Transposase, Mutator family; Region: Transposase_mut; pfam00872 333849005044 MULE transposase domain; Region: MULE; pfam10551 333849005045 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 333849005046 active site 333849005047 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 333849005048 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 333849005049 WHG domain; Region: WHG; pfam13305 333849005050 Protein of unknown function (DUF1576); Region: DUF1576; pfam07613 333849005051 Protein of unknown function (DUF1576); Region: DUF1576; pfam07613 333849005052 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 333849005053 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 333849005054 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 333849005055 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 333849005056 Helix-turn-helix domain; Region: HTH_38; pfam13936 333849005057 Integrase core domain; Region: rve; pfam00665 333849005058 Integrase core domain; Region: rve_3; cl15866 333849005059 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 333849005060 Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; pfam10110 333849005061 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 333849005062 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579 333849005063 putative active site [active] 333849005064 catalytic site [active] 333849005065 putative metal binding site [ion binding]; other site 333849005066 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 333849005067 Helix-turn-helix domain; Region: HTH_38; pfam13936 333849005068 Integrase core domain; Region: rve; pfam00665 333849005069 Integrase core domain; Region: rve_3; cl15866 333849005070 potential frameshift: common BLAST hit: gi|383329763|ref|YP_005355647.1| ISEfm1, transposase 333849005071 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 333849005072 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 333849005073 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 333849005074 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 333849005075 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 333849005076 active site 333849005077 dimer interface [polypeptide binding]; other site 333849005078 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 333849005079 dimer interface [polypeptide binding]; other site 333849005080 active site 333849005081 glutamate dehydrogenase; Provisional; Region: PRK09414 333849005082 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 333849005083 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 333849005084 NAD(P) binding site [chemical binding]; other site 333849005085 Predicted oxidoreductase [General function prediction only]; Region: COG3573 333849005086 HI0933-like protein; Region: HI0933_like; pfam03486 333849005087 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 333849005088 putative deacylase active site [active] 333849005089 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 333849005090 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 333849005091 active site 333849005092 catalytic residue [active] 333849005093 dimer interface [polypeptide binding]; other site 333849005094 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 333849005095 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 333849005096 putative RNA binding site [nucleotide binding]; other site 333849005097 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 333849005098 S-adenosylmethionine binding site [chemical binding]; other site 333849005099 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 333849005100 Sulfatase; Region: Sulfatase; pfam00884 333849005101 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 333849005102 Q-loop/lid; other site 333849005103 ABC transporter signature motif; other site 333849005104 Walker B; other site 333849005105 D-loop; other site 333849005106 H-loop/switch region; other site 333849005107 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 333849005108 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 333849005109 dimerization interface [polypeptide binding]; other site 333849005110 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 333849005111 dimer interface [polypeptide binding]; other site 333849005112 phosphorylation site [posttranslational modification] 333849005113 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 333849005114 ATP binding site [chemical binding]; other site 333849005115 Mg2+ binding site [ion binding]; other site 333849005116 G-X-G motif; other site 333849005117 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 333849005118 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 333849005119 active site 333849005120 phosphorylation site [posttranslational modification] 333849005121 intermolecular recognition site; other site 333849005122 dimerization interface [polypeptide binding]; other site 333849005123 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 333849005124 DNA binding site [nucleotide binding] 333849005125 SdpI/YhfL protein family; Region: SdpI; pfam13630 333849005126 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 333849005127 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 333849005128 active site 333849005129 motif I; other site 333849005130 motif II; other site 333849005131 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 333849005132 Transposase, Mutator family; Region: Transposase_mut; pfam00872 333849005133 MULE transposase domain; Region: MULE; pfam10551 333849005134 Transposase, Mutator family; Region: Transposase_mut; pfam00872 333849005135 MULE transposase domain; Region: MULE; pfam10551 333849005136 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 333849005137 GAF domain; Region: GAF_2; pfam13185 333849005138 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306 333849005139 acetolactate synthase; Reviewed; Region: PRK08617 333849005140 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 333849005141 PYR/PP interface [polypeptide binding]; other site 333849005142 dimer interface [polypeptide binding]; other site 333849005143 TPP binding site [chemical binding]; other site 333849005144 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 333849005145 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 333849005146 TPP-binding site [chemical binding]; other site 333849005147 Transposase, Mutator family; Region: Transposase_mut; pfam00872 333849005148 MULE transposase domain; Region: MULE; pfam10551 333849005149 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 333849005150 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 333849005151 dimer interface [polypeptide binding]; other site 333849005152 conserved gate region; other site 333849005153 putative PBP binding loops; other site 333849005154 ABC-ATPase subunit interface; other site 333849005155 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 333849005156 Transcriptional regulator [Transcription]; Region: LysR; COG0583 333849005157 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 333849005158 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 333849005159 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 333849005160 DNA binding residues [nucleotide binding] 333849005161 putative dimer interface [polypeptide binding]; other site 333849005162 benzoate transport; Region: 2A0115; TIGR00895 333849005163 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 333849005164 putative substrate translocation pore; other site 333849005165 HTH domain; Region: HTH_11; cl17392 333849005166 Mga helix-turn-helix domain; Region: Mga; pfam05043 333849005167 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 333849005168 active site 333849005169 catalytic site [active] 333849005170 Cna protein B-type domain; Region: Cna_B; pfam05738 333849005171 Cna protein B-type domain; Region: Cna_B; pfam05738 333849005172 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 333849005173 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 333849005174 Cna protein B-type domain; Region: Cna_B; pfam05738 333849005175 Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; pfam09860 333849005176 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 333849005177 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 333849005178 Int/Topo IB signature motif; other site 333849005179 Helix-turn-helix domain; Region: HTH_17; pfam12728 333849005180 Helix-turn-helix domain; Region: HTH_16; pfam12645 333849005181 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 333849005182 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 333849005183 DNA binding residues [nucleotide binding] 333849005184 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 333849005185 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 333849005186 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 333849005187 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 333849005188 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 333849005189 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 333849005190 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 333849005191 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 333849005192 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 333849005193 active site 333849005194 metal binding site [ion binding]; metal-binding site 333849005195 Glycosyl hydrolase family 32; Region: GH32_Aec43_like; cd08995 333849005196 active site 333849005197 Glycosyl hydrolases family 32; Region: Glyco_32; smart00640 333849005198 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 333849005199 active pocket/dimerization site; other site 333849005200 active site 333849005201 phosphorylation site [posttranslational modification] 333849005202 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 333849005203 active site 333849005204 phosphorylation site [posttranslational modification] 333849005205 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 333849005206 PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609 333849005207 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 333849005208 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 333849005209 Walker A motif; other site 333849005210 ATP binding site [chemical binding]; other site 333849005211 Walker B motif; other site 333849005212 arginine finger; other site 333849005213 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 333849005214 active site 333849005215 active pocket/dimerization site; other site 333849005216 phosphorylation site [posttranslational modification] 333849005217 PRD domain; Region: PRD; pfam00874 333849005218 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 333849005219 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 333849005220 nucleotide binding site [chemical binding]; other site 333849005221 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 333849005222 HPr interaction site; other site 333849005223 glycerol kinase (GK) interaction site [polypeptide binding]; other site 333849005224 active site 333849005225 phosphorylation site [posttranslational modification] 333849005226 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 333849005227 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 333849005228 active site turn [active] 333849005229 phosphorylation site [posttranslational modification] 333849005230 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 333849005231 Glycosyl hydrolases family 32; Region: Glyco_32; smart00640 333849005232 Glycosyl hydrolase family 32; Region: GH32_Aec43_like; cd08995 333849005233 active site 333849005234 Transcriptional regulators [Transcription]; Region: PurR; COG1609 333849005235 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 333849005236 DNA binding site [nucleotide binding] 333849005237 domain linker motif; other site 333849005238 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 333849005239 dimerization interface [polypeptide binding]; other site 333849005240 ligand binding site [chemical binding]; other site 333849005241 sodium binding site [ion binding]; other site 333849005242 HTH-like domain; Region: HTH_21; pfam13276 333849005243 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 333849005244 Integrase core domain; Region: rve; pfam00665 333849005245 Integrase core domain; Region: rve_3; pfam13683 333849005246 Transposase; Region: HTH_Tnp_1; pfam01527 333849005247 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 333849005248 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 333849005249 MarR family; Region: MarR_2; pfam12802 333849005250 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 333849005251 Helix-turn-helix domain; Region: HTH_38; pfam13936 333849005252 Integrase core domain; Region: rve; pfam00665 333849005253 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 333849005254 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 333849005255 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 333849005256 Integrase core domain; Region: rve; pfam00665 333849005257 transposase/IS protein; Provisional; Region: PRK09183 333849005258 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 333849005259 Walker A motif; other site 333849005260 ATP binding site [chemical binding]; other site 333849005261 Walker B motif; other site 333849005262 arginine finger; other site 333849005263 Conjugative transposon protein TcpC; Region: TpcC; pfam12642 333849005264 Lysozyme-like; Region: Lysozyme_like; pfam13702 333849005265 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 333849005266 NlpC/P60 family; Region: NLPC_P60; pfam00877 333849005267 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 333849005268 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 333849005269 Transposase, Mutator family; Region: Transposase_mut; pfam00872 333849005270 MULE transposase domain; Region: MULE; pfam10551 333849005271 AAA-like domain; Region: AAA_10; pfam12846 333849005272 TcpE family; Region: TcpE; pfam12648 333849005273 AAA domain; Region: AAA_21; pfam13304 333849005274 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 333849005275 ABC transporter signature motif; other site 333849005276 Walker B; other site 333849005277 D-loop; other site 333849005278 H-loop/switch region; other site 333849005279 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 333849005280 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 333849005281 active site 333849005282 AAA domain; Region: AAA_23; pfam13476 333849005283 Antirestriction protein (ArdA); Region: ArdA; pfam07275 333849005284 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 333849005285 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 333849005286 putative active site [active] 333849005287 putative NTP binding site [chemical binding]; other site 333849005288 putative nucleic acid binding site [nucleotide binding]; other site 333849005289 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 333849005290 active site 333849005291 Protein of unknown function (DUF3789); Region: DUF3789; pfam12664 333849005292 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 333849005293 non-specific DNA binding site [nucleotide binding]; other site 333849005294 salt bridge; other site 333849005295 sequence-specific DNA binding site [nucleotide binding]; other site 333849005296 Replication initiation factor; Region: Rep_trans; pfam02486 333849005297 C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145 333849005298 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 333849005299 cofactor binding site; other site 333849005300 DNA binding site [nucleotide binding] 333849005301 substrate interaction site [chemical binding]; other site 333849005302 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 333849005303 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 333849005304 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 333849005305 Walker A motif; other site 333849005306 ATP binding site [chemical binding]; other site 333849005307 Walker B motif; other site 333849005308 arginine finger; other site 333849005309 RelB antitoxin; Region: RelB; cl01171 333849005310 Bacterial protein of unknown function (DUF961); Region: DUF961; pfam06125 333849005311 Bacterial protein of unknown function (DUF961); Region: DUF961; pfam06125 333849005312 Cna protein B-type domain; Region: Cna_B; pfam05738 333849005313 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 333849005314 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 333849005315 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 333849005316 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 333849005317 RimM N-terminal domain; Region: RimM; pfam01782 333849005318 PRC-barrel domain; Region: PRC; pfam05239 333849005319 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 333849005320 KH domain; Region: KH_4; pfam13083 333849005321 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 333849005322 Predicted flavoprotein [General function prediction only]; Region: COG0431 333849005323 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 333849005324 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 333849005325 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl17426 333849005326 folate binding site [chemical binding]; other site 333849005327 NADP+ binding site [chemical binding]; other site 333849005328 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 333849005329 signal recognition particle protein; Provisional; Region: PRK10867 333849005330 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 333849005331 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 333849005332 P loop; other site 333849005333 GTP binding site [chemical binding]; other site 333849005334 Signal peptide binding domain; Region: SRP_SPB; pfam02978 333849005335 putative DNA-binding protein; Validated; Region: PRK00118 333849005336 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 333849005337 Protein of unknown function (DUF523); Region: DUF523; pfam04463 333849005338 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 333849005339 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 333849005340 active site 333849005341 phosphorylation site [posttranslational modification] 333849005342 intermolecular recognition site; other site 333849005343 dimerization interface [polypeptide binding]; other site 333849005344 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 333849005345 DNA binding site [nucleotide binding] 333849005346 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 333849005347 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 333849005348 dimer interface [polypeptide binding]; other site 333849005349 phosphorylation site [posttranslational modification] 333849005350 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 333849005351 ATP binding site [chemical binding]; other site 333849005352 Mg2+ binding site [ion binding]; other site 333849005353 G-X-G motif; other site 333849005354 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 333849005355 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 333849005356 Soluble P-type ATPase [General function prediction only]; Region: COG4087 333849005357 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 333849005358 Transposase; Region: DDE_Tnp_ISL3; pfam01610 333849005359 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 333849005360 Transposase; Region: DDE_Tnp_ISL3; pfam01610 333849005361 potential frameshift: common BLAST hit: gi|383329078|ref|YP_005354962.1| IS1251-like transposase 333849005362 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 333849005363 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 333849005364 Homeodomain-like domain; Region: HTH_23; pfam13384 333849005365 Transposase; Region: DDE_Tnp_ISL3; pfam01610 333849005366 Transposase; Region: DDE_Tnp_ISL3; pfam01610 333849005367 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 333849005368 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 333849005369 phosphate binding protein; Region: ptsS_2; TIGR02136 333849005370 Transposase, Mutator family; Region: Transposase_mut; pfam00872 333849005371 MULE transposase domain; Region: MULE; pfam10551 333849005372 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 333849005373 Transposase; Region: DDE_Tnp_ISL3; pfam01610 333849005374 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 333849005375 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 333849005376 active site 333849005377 potential frameshift: common BLAST hit: gi|383329975|ref|YP_005355859.1| IS116/IS110/IS902 family transposase 333849005378 Transposase; Region: DEDD_Tnp_IS110; pfam01548 333849005379 potential frameshift: common BLAST hit: gi|383329975|ref|YP_005355859.1| IS116/IS110/IS902 family transposase 333849005380 Transposase; Region: DEDD_Tnp_IS110; pfam01548 333849005381 potential frameshift: common BLAST hit: gi|383329975|ref|YP_005355859.1| IS116/IS110/IS902 family transposase 333849005382 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 333849005383 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 333849005384 Protein of unknown function (DUF4231); Region: DUF4231; pfam14015 333849005385 potential frameshift: common BLAST hit: gi|383327530|ref|YP_005353414.1| ISEnfa3, transposase 333849005386 Integrase core domain; Region: rve; pfam00665 333849005387 Integrase core domain; Region: rve_2; pfam13333 333849005388 HTH-like domain; Region: HTH_21; pfam13276 333849005389 Integrase core domain; Region: rve; pfam00665 333849005390 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 333849005391 Helix-turn-helix domain; Region: HTH_28; pfam13518 333849005392 Helix-turn-helix domain; Region: HTH_28; pfam13518 333849005393 Winged helix-turn helix; Region: HTH_29; pfam13551 333849005394 Homeodomain-like domain; Region: HTH_32; pfam13565 333849005395 Transposase, Mutator family; Region: Transposase_mut; pfam00872 333849005396 MULE transposase domain; Region: MULE; pfam10551 333849005397 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 333849005398 Helix-turn-helix domain; Region: HTH_28; pfam13518 333849005399 Helix-turn-helix domain; Region: HTH_28; pfam13518 333849005400 Winged helix-turn helix; Region: HTH_29; pfam13551 333849005401 Homeodomain-like domain; Region: HTH_32; pfam13565 333849005402 HTH-like domain; Region: HTH_21; pfam13276 333849005403 Integrase core domain; Region: rve; pfam00665 333849005404 Integrase core domain; Region: rve; pfam00665 333849005405 Integrase core domain; Region: rve_2; pfam13333 333849005406 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cl02712 333849005407 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 333849005408 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 333849005409 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 333849005410 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 333849005411 Walker A motif; other site 333849005412 ATP binding site [chemical binding]; other site 333849005413 Walker B motif; other site 333849005414 arginine finger; other site 333849005415 Protein of unknown function DUF58; Region: DUF58; pfam01882 333849005416 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 333849005417 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 333849005418 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 333849005419 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 333849005420 motif II; other site 333849005421 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 333849005422 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 333849005423 metal-binding site [ion binding] 333849005424 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 333849005425 Soluble P-type ATPase [General function prediction only]; Region: COG4087 333849005426 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 333849005427 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 333849005428 metal-binding site [ion binding] 333849005429 copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698 333849005430 Penicillinase repressor; Region: Pencillinase_R; pfam03965 333849005431 topology modulation protein; Reviewed; Region: PRK08118 333849005432 AAA domain; Region: AAA_17; pfam13207 333849005433 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 333849005434 Transposase; Region: DDE_Tnp_ISL3; pfam01610 333849005435 inner membrane transporter YjeM; Provisional; Region: PRK15238 333849005436 potential frameshift: common BLAST hit: gi|383329239|ref|YP_005355123.1| cadmium-translocating P-type ATPase 333849005437 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 333849005438 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 333849005439 Soluble P-type ATPase [General function prediction only]; Region: COG4087 333849005440 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 333849005441 metal-binding site [ion binding] 333849005442 Putative cyclase; Region: Cyclase; cl00814 333849005443 hypothetical protein; Provisional; Region: PRK11770 333849005444 Domain of unknown function (DUF307); Region: DUF307; pfam03733 333849005445 Domain of unknown function (DUF307); Region: DUF307; pfam03733 333849005446 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_2; cd01834 333849005447 active site 333849005448 catalytic triad [active] 333849005449 oxyanion hole [active] 333849005450 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 333849005451 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 333849005452 putative dimer interface [polypeptide binding]; other site 333849005453 putative anticodon binding site; other site 333849005454 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 333849005455 homodimer interface [polypeptide binding]; other site 333849005456 motif 1; other site 333849005457 motif 2; other site 333849005458 active site 333849005459 motif 3; other site 333849005460 aspartate aminotransferase; Provisional; Region: PRK05764 333849005461 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 333849005462 pyridoxal 5'-phosphate binding site [chemical binding]; other site 333849005463 homodimer interface [polypeptide binding]; other site 333849005464 catalytic residue [active] 333849005465 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 333849005466 Endonuclease related to archaeal Holliday junction resolvase; Region: Endonuc_Holl; cl01958 333849005467 DnaQ family exonuclease/DinG family helicase, putative; Region: dinG_rel; TIGR01407 333849005468 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 333849005469 active site 333849005470 catalytic site [active] 333849005471 substrate binding site [chemical binding]; other site 333849005472 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 333849005473 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12294 333849005474 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 333849005475 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 333849005476 DNA-binding site [nucleotide binding]; DNA binding site 333849005477 RNA-binding motif; other site 333849005478 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 333849005479 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 333849005480 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 333849005481 Uncharacterized conserved protein [Function unknown]; Region: COG1434 333849005482 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 333849005483 putative active site [active] 333849005484 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 333849005485 ClC sycA-like chloride channel proteins. This ClC family presents in bacteria, where it facilitates acid resistance in acidic soil. Mutation of this gene (sycA) in Rhizobium tropici CIAT899 causes serious deficiencies in nodule development, nodulation...; Region: ClC_sycA_like; cd03682 333849005486 putative Cl- selectivity filter; other site 333849005487 putative pore gating glutamate residue; other site 333849005488 Fibronectin-binding protein (FBP); Region: FBP; pfam07299 333849005489 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 333849005490 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 333849005491 Zn2+ binding site [ion binding]; other site 333849005492 Mg2+ binding site [ion binding]; other site 333849005493 potential frameshift: common BLAST hit: gi|383329257|ref|YP_005355141.1| RNA methyltransferase 333849005494 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 333849005495 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 333849005496 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 333849005497 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 333849005498 Acylphosphatases [Energy production and conversion]; Region: AcyP; COG1254 333849005499 OxaA-like protein precursor; Provisional; Region: PRK02463 333849005500 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 333849005501 Transposase domain (DUF772); Region: DUF772; pfam05598 333849005502 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 333849005503 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 333849005504 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 333849005505 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 333849005506 Coenzyme A binding pocket [chemical binding]; other site 333849005507 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 333849005508 active site 333849005509 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 333849005510 Transposase; Region: HTH_Tnp_1; pfam01527 333849005511 putative transposase OrfB; Reviewed; Region: PHA02517 333849005512 HTH-like domain; Region: HTH_21; pfam13276 333849005513 Integrase core domain; Region: rve; pfam00665 333849005514 Integrase core domain; Region: rve_2; pfam13333 333849005515 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 333849005516 Helix-turn-helix domain; Region: HTH_38; pfam13936 333849005517 Integrase core domain; Region: rve; pfam00665 333849005518 Integrase core domain; Region: rve_3; cl15866 333849005519 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 333849005520 Phage-related protein [Function unknown]; Region: COG4695; cl01923 333849005521 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 333849005522 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 333849005523 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 333849005524 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 333849005525 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 333849005526 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 333849005527 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 333849005528 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 333849005529 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 333849005530 non-specific DNA binding site [nucleotide binding]; other site 333849005531 salt bridge; other site 333849005532 sequence-specific DNA binding site [nucleotide binding]; other site 333849005533 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 333849005534 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 333849005535 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 333849005536 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 333849005537 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 333849005538 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 333849005539 active site 333849005540 substrate binding site [chemical binding]; other site 333849005541 metal binding site [ion binding]; metal-binding site 333849005542 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 333849005543 dimer interface [polypeptide binding]; other site 333849005544 ADP-ribose binding site [chemical binding]; other site 333849005545 active site 333849005546 nudix motif; other site 333849005547 metal binding site [ion binding]; metal-binding site 333849005548 potential frameshift: common BLAST hit: gi|317131822|ref|YP_004091136.1| ROK family glucokinase 333849005549 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 333849005550 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 333849005551 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 333849005552 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 333849005553 Substrate binding site; other site 333849005554 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 333849005555 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 333849005556 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 333849005557 NADP binding site [chemical binding]; other site 333849005558 active site 333849005559 putative substrate binding site [chemical binding]; other site 333849005560 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 333849005561 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 333849005562 NADP-binding site; other site 333849005563 homotetramer interface [polypeptide binding]; other site 333849005564 substrate binding site [chemical binding]; other site 333849005565 homodimer interface [polypeptide binding]; other site 333849005566 active site 333849005567 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cl04270 333849005568 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 333849005569 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 333849005570 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 333849005571 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 333849005572 O-Antigen ligase; Region: Wzy_C; cl04850 333849005573 Glycosyl transferase family 11; Region: Glyco_transf_11; pfam01531 333849005574 Alpha-1,2-fucosyltransferase; Region: Fut1_Fut2_like; cd11301 333849005575 GDP-Fucose binding site [chemical binding]; other site 333849005576 transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283 333849005577 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 333849005578 metal-binding site 333849005579 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 333849005580 UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057 333849005581 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 333849005582 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 333849005583 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 333849005584 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 333849005585 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 333849005586 putative NAD(P) binding site [chemical binding]; other site 333849005587 active site 333849005588 putative substrate binding site [chemical binding]; other site 333849005589 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 333849005590 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 333849005591 Bacterial sugar transferase; Region: Bac_transf; cl00939 333849005592 UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057 333849005593 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 333849005594 Helix-turn-helix domain; Region: HTH_38; pfam13936 333849005595 Integrase core domain; Region: rve; pfam00665 333849005596 Integrase core domain; Region: rve_3; cl15866 333849005597 Domain of unknown function (DUF1972); Region: DUF1972; pfam09314 333849005598 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 333849005599 Bacterial sugar transferase; Region: Bac_transf; pfam02397 333849005600 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 333849005601 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 333849005602 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 333849005603 Chain length determinant protein; Region: Wzz; cl15801 333849005604 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 333849005605 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 333849005606 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 333849005607 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; smart00471 333849005608 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 333849005609 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 333849005610 dimer interface [polypeptide binding]; other site 333849005611 motif 1; other site 333849005612 active site 333849005613 motif 2; other site 333849005614 motif 3; other site 333849005615 T-box leader; HMPREF0351_nc10020 333849005616 Recombination protein O N terminal; Region: RecO_N; pfam11967 333849005617 DNA repair protein RecO; Region: reco; TIGR00613 333849005618 Recombination protein O C terminal; Region: RecO_C; pfam02565 333849005619 GTPase Era; Reviewed; Region: era; PRK00089 333849005620 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 333849005621 G1 box; other site 333849005622 GTP/Mg2+ binding site [chemical binding]; other site 333849005623 Switch I region; other site 333849005624 G2 box; other site 333849005625 Switch II region; other site 333849005626 G3 box; other site 333849005627 G4 box; other site 333849005628 G5 box; other site 333849005629 KH domain; Region: KH_2; pfam07650 333849005630 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 333849005631 metal-binding heat shock protein; Provisional; Region: PRK00016 333849005632 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 333849005633 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 333849005634 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 333849005635 Zn2+ binding site [ion binding]; other site 333849005636 Mg2+ binding site [ion binding]; other site 333849005637 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 333849005638 PhoH-like protein; Region: PhoH; pfam02562 333849005639 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 333849005640 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 333849005641 Transposase; Region: DDE_Tnp_ISL3; pfam01610 333849005642 Yqey-like protein; Region: YqeY; pfam09424 333849005643 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 333849005644 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 333849005645 metal binding site 2 [ion binding]; metal-binding site 333849005646 putative DNA binding helix; other site 333849005647 metal binding site 1 [ion binding]; metal-binding site 333849005648 dimer interface [polypeptide binding]; other site 333849005649 structural Zn2+ binding site [ion binding]; other site 333849005650 Kinase/pyrophosphorylase; Region: Kinase-PPPase; pfam03618 333849005651 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 333849005652 dimerization interface [polypeptide binding]; other site 333849005653 putative DNA binding site [nucleotide binding]; other site 333849005654 putative Zn2+ binding site [ion binding]; other site 333849005655 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 333849005656 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 333849005657 active site 333849005658 substrate binding site [chemical binding]; other site 333849005659 metal binding site [ion binding]; metal-binding site 333849005660 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 333849005661 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 333849005662 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 333849005663 6-phospho-beta-glucosidase; Reviewed; Region: arb; PRK09593 333849005664 beta-galactosidase; Region: BGL; TIGR03356 333849005665 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 333849005666 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 333849005667 NAD binding site [chemical binding]; other site 333849005668 sugar binding site [chemical binding]; other site 333849005669 divalent metal binding site [ion binding]; other site 333849005670 tetramer (dimer of dimers) interface [polypeptide binding]; other site 333849005671 dimer interface [polypeptide binding]; other site 333849005672 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 333849005673 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 333849005674 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 333849005675 putative active site [active] 333849005676 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 333849005677 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 333849005678 active site turn [active] 333849005679 phosphorylation site [posttranslational modification] 333849005680 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 333849005681 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 333849005682 HPr interaction site; other site 333849005683 glycerol kinase (GK) interaction site [polypeptide binding]; other site 333849005684 active site 333849005685 phosphorylation site [posttranslational modification] 333849005686 transcriptional antiterminator BglG; Provisional; Region: PRK09772 333849005687 CAT RNA binding domain; Region: CAT_RBD; smart01061 333849005688 PRD domain; Region: PRD; pfam00874 333849005689 PRD domain; Region: PRD; pfam00874 333849005690 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 333849005691 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 333849005692 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 333849005693 Walker A/P-loop; other site 333849005694 ATP binding site [chemical binding]; other site 333849005695 Q-loop/lid; other site 333849005696 ABC transporter signature motif; other site 333849005697 Walker B; other site 333849005698 D-loop; other site 333849005699 H-loop/switch region; other site 333849005700 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 333849005701 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 333849005702 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 333849005703 Walker A/P-loop; other site 333849005704 ATP binding site [chemical binding]; other site 333849005705 Q-loop/lid; other site 333849005706 ABC transporter signature motif; other site 333849005707 Walker B; other site 333849005708 D-loop; other site 333849005709 H-loop/switch region; other site 333849005710 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3763 333849005711 manganese transport protein MntH; Reviewed; Region: PRK00701 333849005712 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 333849005713 endonuclease IV; Provisional; Region: PRK01060 333849005714 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 333849005715 AP (apurinic/apyrimidinic) site pocket; other site 333849005716 DNA interaction; other site 333849005717 Metal-binding active site; metal-binding site 333849005718 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 333849005719 Transglycosylase; Region: Transgly; pfam00912 333849005720 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 333849005721 catabolite control protein A; Region: ccpA; TIGR01481 333849005722 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 333849005723 DNA binding site [nucleotide binding] 333849005724 domain linker motif; other site 333849005725 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 333849005726 dimerization interface [polypeptide binding]; other site 333849005727 effector binding site; other site 333849005728 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 333849005729 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 333849005730 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 333849005731 active site 333849005732 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 333849005733 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 333849005734 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 333849005735 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 333849005736 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 333849005737 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 333849005738 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 333849005739 Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768 333849005740 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 333849005741 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 333849005742 active site 333849005743 tetramer interface; other site 333849005744 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 333849005745 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 333849005746 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 333849005747 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 333849005748 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 333849005749 HPr kinase/phosphorylase; Provisional; Region: PRK05428 333849005750 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 333849005751 Hpr binding site; other site 333849005752 active site 333849005753 homohexamer subunit interaction site [polypeptide binding]; other site 333849005754 Membrane protein of unknown function; Region: DUF360; pfam04020 333849005755 PspC domain; Region: PspC; pfam04024 333849005756 Uncharacterized conserved protein [Function unknown]; Region: COG3595 333849005757 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 333849005758 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 333849005759 YibE/F-like protein; Region: YibE_F; pfam07907 333849005760 YibE/F-like protein; Region: YibE_F; pfam07907 333849005761 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 333849005762 PhoU domain; Region: PhoU; pfam01895 333849005763 PhoU domain; Region: PhoU; pfam01895 333849005764 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 333849005765 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 333849005766 Walker A/P-loop; other site 333849005767 ATP binding site [chemical binding]; other site 333849005768 Q-loop/lid; other site 333849005769 ABC transporter signature motif; other site 333849005770 Walker B; other site 333849005771 D-loop; other site 333849005772 H-loop/switch region; other site 333849005773 phosphate transporter ATP-binding protein; Provisional; Region: PRK14237 333849005774 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 333849005775 Walker A/P-loop; other site 333849005776 ATP binding site [chemical binding]; other site 333849005777 Q-loop/lid; other site 333849005778 ABC transporter signature motif; other site 333849005779 Walker B; other site 333849005780 D-loop; other site 333849005781 H-loop/switch region; other site 333849005782 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 333849005783 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 333849005784 dimer interface [polypeptide binding]; other site 333849005785 conserved gate region; other site 333849005786 putative PBP binding loops; other site 333849005787 ABC-ATPase subunit interface; other site 333849005788 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 333849005789 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 333849005790 dimer interface [polypeptide binding]; other site 333849005791 conserved gate region; other site 333849005792 putative PBP binding loops; other site 333849005793 ABC-ATPase subunit interface; other site 333849005794 phosphate binding protein; Region: ptsS_2; TIGR02136 333849005795 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 333849005796 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 333849005797 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 333849005798 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 333849005799 putative active site [active] 333849005800 catalytic site [active] 333849005801 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 333849005802 putative active site [active] 333849005803 catalytic site [active] 333849005804 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 333849005805 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 333849005806 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 333849005807 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 333849005808 Walker A/P-loop; other site 333849005809 ATP binding site [chemical binding]; other site 333849005810 Q-loop/lid; other site 333849005811 ABC transporter signature motif; other site 333849005812 Walker B; other site 333849005813 D-loop; other site 333849005814 H-loop/switch region; other site 333849005815 peptide chain release factor 2; Provisional; Region: PRK05589 333849005816 This domain is found in peptide chain release factors; Region: PCRF; smart00937 333849005817 RF-1 domain; Region: RF-1; pfam00472 333849005818 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 333849005819 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 333849005820 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 333849005821 nucleotide binding region [chemical binding]; other site 333849005822 ATP-binding site [chemical binding]; other site 333849005823 SEC-C motif; Region: SEC-C; pfam02810 333849005824 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 333849005825 30S subunit binding site; other site 333849005826 comF family protein; Region: comF; TIGR00201 333849005827 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 333849005828 active site 333849005829 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 333849005830 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 333849005831 ATP binding site [chemical binding]; other site 333849005832 putative Mg++ binding site [ion binding]; other site 333849005833 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 333849005834 nucleotide binding region [chemical binding]; other site 333849005835 ATP-binding site [chemical binding]; other site 333849005836 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 333849005837 active site 333849005838 P-loop; other site 333849005839 phosphorylation site [posttranslational modification] 333849005840 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 333849005841 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 333849005842 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 333849005843 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 333849005844 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 333849005845 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 333849005846 DNA-binding site [nucleotide binding]; DNA binding site 333849005847 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 333849005848 Protein of unknown function (DUF2969); Region: DUF2969; pfam11184 333849005849 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 333849005850 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 333849005851 nucleotide binding site [chemical binding]; other site 333849005852 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 333849005853 Coenzyme A binding pocket [chemical binding]; other site 333849005854 Haemolytic domain; Region: Haemolytic; pfam01809 333849005855 DNA-directed RNA polymerase subunit beta; Region: EpuA; pfam11772 333849005856 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 333849005857 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 333849005858 hinge; other site 333849005859 active site 333849005860 conserved hypothetical integral membrane protein; Region: int_mem_ywzB; TIGR02327 333849005861 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 333849005862 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 333849005863 gamma subunit interface [polypeptide binding]; other site 333849005864 epsilon subunit interface [polypeptide binding]; other site 333849005865 LBP interface [polypeptide binding]; other site 333849005866 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 333849005867 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 333849005868 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 333849005869 alpha subunit interaction interface [polypeptide binding]; other site 333849005870 Walker A motif; other site 333849005871 ATP binding site [chemical binding]; other site 333849005872 Walker B motif; other site 333849005873 inhibitor binding site; inhibition site 333849005874 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 333849005875 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 333849005876 core domain interface [polypeptide binding]; other site 333849005877 delta subunit interface [polypeptide binding]; other site 333849005878 epsilon subunit interface [polypeptide binding]; other site 333849005879 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 333849005880 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 333849005881 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 333849005882 beta subunit interaction interface [polypeptide binding]; other site 333849005883 Walker A motif; other site 333849005884 ATP binding site [chemical binding]; other site 333849005885 Walker B motif; other site 333849005886 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 333849005887 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 333849005888 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 333849005889 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 333849005890 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 333849005891 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 333849005892 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 333849005893 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 333849005894 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 333849005895 SmpB-tmRNA interface; other site 333849005896 ribonuclease R; Region: RNase_R; TIGR02063 333849005897 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 333849005898 RNB domain; Region: RNB; pfam00773 333849005899 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 333849005900 RNA binding site [nucleotide binding]; other site 333849005901 Esterase/lipase [General function prediction only]; Region: COG1647 333849005902 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 333849005903 Preprotein translocase SecG subunit; Region: SecG; pfam03840 333849005904 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 333849005905 Coenzyme A binding pocket [chemical binding]; other site 333849005906 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 333849005907 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 333849005908 NH_3: A subgroup of nucleoside hydrolases. This group contains eukaryotic and bacterial proteins similar to nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes...; Region: nuc_hydro_3; cd02653 333849005909 active site 333849005910 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 333849005911 potential frameshift: common BLAST hit: gi|383329390|ref|YP_005355274.1| succinyl-diaminopimelate desuccinylase 333849005912 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 333849005913 metal binding site [ion binding]; metal-binding site 333849005914 dimer interface [polypeptide binding]; other site 333849005915 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 333849005916 enolase; Provisional; Region: eno; PRK00077 333849005917 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 333849005918 dimer interface [polypeptide binding]; other site 333849005919 metal binding site [ion binding]; metal-binding site 333849005920 substrate binding pocket [chemical binding]; other site 333849005921 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 333849005922 triosephosphate isomerase; Provisional; Region: PRK14565 333849005923 substrate binding site [chemical binding]; other site 333849005924 dimer interface [polypeptide binding]; other site 333849005925 catalytic triad [active] 333849005926 Phosphoglycerate kinase; Region: PGK; pfam00162 333849005927 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 333849005928 substrate binding site [chemical binding]; other site 333849005929 hinge regions; other site 333849005930 ADP binding site [chemical binding]; other site 333849005931 catalytic site [active] 333849005932 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 333849005933 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 333849005934 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 333849005935 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 333849005936 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 333849005937 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 333849005938 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 333849005939 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 333849005940 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 333849005941 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 333849005942 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 333849005943 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 333849005944 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 333849005945 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 333849005946 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 333849005947 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 333849005948 DNA binding residues [nucleotide binding] 333849005949 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066 333849005950 Domain of unknown function (DUF1934); Region: DUF1934; pfam09148 333849005951 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 333849005952 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 333849005953 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 333849005954 Zn2+ binding site [ion binding]; other site 333849005955 Mg2+ binding site [ion binding]; other site 333849005956 sugar phosphate phosphatase; Provisional; Region: PRK10513 333849005957 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 333849005958 active site 333849005959 motif I; other site 333849005960 motif II; other site 333849005961 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 333849005962 Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684 333849005963 nudix motif; other site 333849005964 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 333849005965 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 333849005966 dimer interface [polypeptide binding]; other site 333849005967 active site 333849005968 metal binding site [ion binding]; metal-binding site 333849005969 glutathione binding site [chemical binding]; other site 333849005970 potential frameshift: common BLAST hit: gi|383329407|ref|YP_005355291.1| phenazine biosynthesis protein PhzF family protein 333849005971 Phenazine biosynthesis-like protein; Region: PhzC-PhzF; pfam02567 333849005972 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 333849005973 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 333849005974 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 333849005975 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 333849005976 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 333849005977 DNA-binding site [nucleotide binding]; DNA binding site 333849005978 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 333849005979 pyridoxal 5'-phosphate binding site [chemical binding]; other site 333849005980 homodimer interface [polypeptide binding]; other site 333849005981 catalytic residue [active] 333849005982 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 333849005983 Cation transport protein; Region: TrkH; pfam02386 333849005984 V-type ATP synthase subunit D; Reviewed; Region: PRK00373 333849005985 V-type ATP synthase subunit B; Provisional; Region: PRK04196 333849005986 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 333849005987 V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_B; cd01135 333849005988 Walker A motif homologous position; other site 333849005989 Walker B motif; other site 333849005990 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 333849005991 V-type ATP synthase subunit A; Provisional; Region: PRK04192 333849005992 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 333849005993 V/A-type ATP synthase catalytic subunit A. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_A; cd01134 333849005994 Walker A motif/ATP binding site; other site 333849005995 Walker B motif; other site 333849005996 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 333849005997 V-type ATP synthase subunit F; Provisional; Region: PRK01395 333849005998 Archaeal/vacuolar-type H+-ATPase subunit C [Energy production and conversion]; Region: NtpC; COG1527 333849005999 V-type ATP synthase subunit C; Provisional; Region: PRK01198; cl00660 333849006000 V-type ATP synthase subunit K; Validated; Region: PRK06558 333849006001 ATP synthase subunit C; Region: ATP-synt_C; pfam00137 333849006002 ATP synthase subunit C; Region: ATP-synt_C; pfam00137 333849006003 V-type ATP synthase subunit I; Validated; Region: PRK05771 333849006004 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 333849006005 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 333849006006 catalytic triad [active] 333849006007 Firmicute fructose-1,6-bisphosphatase; Region: FBPase_2; pfam06874 333849006008 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 333849006009 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 333849006010 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 333849006011 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 333849006012 Walker A/P-loop; other site 333849006013 ATP binding site [chemical binding]; other site 333849006014 Q-loop/lid; other site 333849006015 ABC transporter signature motif; other site 333849006016 Walker B; other site 333849006017 D-loop; other site 333849006018 H-loop/switch region; other site 333849006019 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 333849006020 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 333849006021 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 333849006022 GIY-YIG motif/motif A; other site 333849006023 active site 333849006024 catalytic site [active] 333849006025 putative DNA binding site [nucleotide binding]; other site 333849006026 metal binding site [ion binding]; metal-binding site 333849006027 UvrB/uvrC motif; Region: UVR; pfam02151 333849006028 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 333849006029 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 333849006030 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 333849006031 catalytic residues [active] 333849006032 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 333849006033 MutS domain III; Region: MutS_III; pfam05192 333849006034 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 333849006035 Walker A/P-loop; other site 333849006036 ATP binding site [chemical binding]; other site 333849006037 Q-loop/lid; other site 333849006038 ABC transporter signature motif; other site 333849006039 Walker B; other site 333849006040 D-loop; other site 333849006041 H-loop/switch region; other site 333849006042 Smr domain; Region: Smr; pfam01713 333849006043 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 333849006044 Colicin V production protein; Region: Colicin_V; pfam02674 333849006045 Cell division protein ZapA; Region: ZapA; cl01146 333849006046 ribonuclease HIII; Provisional; Region: PRK00996 333849006047 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 333849006048 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 333849006049 RNA/DNA hybrid binding site [nucleotide binding]; other site 333849006050 active site 333849006051 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 333849006052 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 333849006053 active site 333849006054 metal binding site [ion binding]; metal-binding site 333849006055 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 333849006056 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 333849006057 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 333849006058 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 333849006059 Walker A/P-loop; other site 333849006060 ATP binding site [chemical binding]; other site 333849006061 Q-loop/lid; other site 333849006062 ABC transporter signature motif; other site 333849006063 Walker B; other site 333849006064 D-loop; other site 333849006065 H-loop/switch region; other site 333849006066 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 333849006067 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 333849006068 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 333849006069 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 333849006070 Mga helix-turn-helix domain; Region: Mga; pfam05043 333849006071 electron transport complex protein RnfC; Provisional; Region: PRK05035 333849006072 WxL domain surface cell wall-binding; Region: WxL; pfam13731 333849006073 L-lactate oxidase; Region: L_lactate_ox; TIGR02708 333849006074 L-Lactate oxidase (LOX) FMN-binding domain. LOX is a member of the family of FMN-containing alpha-hydroxyacid oxidases and catalyzes the oxidation of l-lactate using molecular oxygen to generate pyruvate and H2O2. This family occurs in both prokaryotes...; Region: LOX_like_FMN; cd04737 333849006075 teramer interface [polypeptide binding]; other site 333849006076 active site 333849006077 FMN binding site [chemical binding]; other site 333849006078 catalytic residues [active] 333849006079 malate dehydrogenase; Provisional; Region: PRK13529 333849006080 Malic enzyme, N-terminal domain; Region: malic; pfam00390 333849006081 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 333849006082 NAD(P) binding site [chemical binding]; other site 333849006083 2-hydroxycarboxylate transporter family; Region: 2HCT; pfam03390 333849006084 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 333849006085 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 333849006086 Coenzyme A binding pocket [chemical binding]; other site 333849006087 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 333849006088 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 333849006089 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 333849006090 oligomerization interface [polypeptide binding]; other site 333849006091 Caudovirus prohead protease; Region: Peptidase_U35; pfam04586 333849006092 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 333849006093 Phage capsid family; Region: Phage_capsid; pfam05065 333849006094 Phage portal protein; Region: Phage_portal; pfam04860 333849006095 Phage-related protein [Function unknown]; Region: COG4695; cl01923 333849006096 Phage Terminase; Region: Terminase_1; pfam03354 333849006097 Phage terminase, small subunit; Region: Terminase_4; pfam05119 333849006098 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 333849006099 Protein of unknown function (DUF3206); Region: DUF3206; pfam11472 333849006100 Virulence-associated protein E; Region: VirE; pfam05272 333849006101 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 333849006102 polymerase nucleotide-binding site; other site 333849006103 DNA-binding residues [nucleotide binding]; DNA binding site 333849006104 nucleotide binding site [chemical binding]; other site 333849006105 primase nucleotide-binding site [nucleotide binding]; other site 333849006106 Primase C terminal 1 (PriCT-1); Region: PriCT_1; pfam08708 333849006107 BRO family, N-terminal domain; Region: Bro-N; cl10591 333849006108 Prophage antirepressor [Transcription]; Region: COG3617 333849006109 BRO family, N-terminal domain; Region: Bro-N; smart01040 333849006110 Helix-turn-helix domain; Region: HTH_17; cl17695 333849006111 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 333849006112 non-specific DNA binding site [nucleotide binding]; other site 333849006113 salt bridge; other site 333849006114 sequence-specific DNA binding site [nucleotide binding]; other site 333849006115 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 333849006116 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 333849006117 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 333849006118 Int/Topo IB signature motif; other site 333849006119 hypothetical protein; Provisional; Region: PRK13678 333849006120 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 333849006121 hypothetical protein; Provisional; Region: PRK05473 333849006122 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; pfam13930 333849006123 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 333849006124 Uncharacterized conserved protein [Function unknown]; Region: COG2966 333849006125 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 333849006126 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 333849006127 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 333849006128 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 333849006129 Walker A/P-loop; other site 333849006130 ATP binding site [chemical binding]; other site 333849006131 Q-loop/lid; other site 333849006132 ABC transporter signature motif; other site 333849006133 Walker B; other site 333849006134 D-loop; other site 333849006135 H-loop/switch region; other site 333849006136 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 333849006137 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 333849006138 active site 333849006139 phosphorylation site [posttranslational modification] 333849006140 intermolecular recognition site; other site 333849006141 dimerization interface [polypeptide binding]; other site 333849006142 LytTr DNA-binding domain; Region: LytTR; cl04498 333849006143 Domain of unknown function (DUF1980); Region: DUF1980; cl01492 333849006144 Predicted permeases [General function prediction only]; Region: COG0701 333849006145 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 333849006146 catalytic residues [active] 333849006147 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 333849006148 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 333849006149 CoA binding domain; Region: CoA_binding; pfam02629 333849006150 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 333849006151 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 333849006152 Walker A/P-loop; other site 333849006153 ATP binding site [chemical binding]; other site 333849006154 Q-loop/lid; other site 333849006155 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 333849006156 ABC transporter signature motif; other site 333849006157 Walker B; other site 333849006158 D-loop; other site 333849006159 ABC transporter; Region: ABC_tran_2; pfam12848 333849006160 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 333849006161 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 333849006162 Uncharacterized protein conserved in bacteria (DUF2264); Region: DUF2264; pfam10022 333849006163 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 333849006164 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 333849006165 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 333849006166 dimer interface [polypeptide binding]; other site 333849006167 conserved gate region; other site 333849006168 putative PBP binding loops; other site 333849006169 ABC-ATPase subunit interface; other site 333849006170 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 333849006171 dimer interface [polypeptide binding]; other site 333849006172 conserved gate region; other site 333849006173 putative PBP binding loops; other site 333849006174 ABC-ATPase subunit interface; other site 333849006175 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 333849006176 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 333849006177 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 333849006178 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 333849006179 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 333849006180 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 333849006181 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 333849006182 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 333849006183 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 333849006184 active site residue [active] 333849006185 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 333849006186 Helix-turn-helix domain; Region: HTH_38; pfam13936 333849006187 Integrase core domain; Region: rve; pfam00665 333849006188 Integrase core domain; Region: rve_3; cl15866 333849006189 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 333849006190 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 333849006191 HflX GTPase family; Region: HflX; cd01878 333849006192 G1 box; other site 333849006193 GTP/Mg2+ binding site [chemical binding]; other site 333849006194 Switch I region; other site 333849006195 G2 box; other site 333849006196 G3 box; other site 333849006197 Switch II region; other site 333849006198 G4 box; other site 333849006199 G5 box; other site 333849006200 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 333849006201 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 333849006202 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 333849006203 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 333849006204 active site 333849006205 catalytic site [active] 333849006206 metal binding site [ion binding]; metal-binding site 333849006207 dimer interface [polypeptide binding]; other site 333849006208 Clp protease; Region: CLP_protease; pfam00574 333849006209 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 333849006210 oligomer interface [polypeptide binding]; other site 333849006211 active site residues [active] 333849006212 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 333849006213 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 333849006214 trimer interface [polypeptide binding]; other site 333849006215 putative metal binding site [ion binding]; other site 333849006216 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 333849006217 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 333849006218 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 333849006219 Walker A/P-loop; other site 333849006220 ATP binding site [chemical binding]; other site 333849006221 Q-loop/lid; other site 333849006222 ABC transporter signature motif; other site 333849006223 Walker B; other site 333849006224 D-loop; other site 333849006225 H-loop/switch region; other site 333849006226 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 333849006227 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 333849006228 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 333849006229 Walker A/P-loop; other site 333849006230 ATP binding site [chemical binding]; other site 333849006231 Q-loop/lid; other site 333849006232 ABC transporter signature motif; other site 333849006233 Walker B; other site 333849006234 D-loop; other site 333849006235 H-loop/switch region; other site 333849006236 Protein of unknown function (DUF1447); Region: DUF1447; pfam07288 333849006237 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 333849006238 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 333849006239 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 333849006240 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 333849006241 hypothetical protein; Reviewed; Region: PRK00024 333849006242 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 333849006243 MPN+ (JAMM) motif; other site 333849006244 Zinc-binding site [ion binding]; other site 333849006245 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 333849006246 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 333849006247 motif II; other site 333849006248 folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499 333849006249 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 333849006250 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 333849006251 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 333849006252 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 333849006253 active site 333849006254 HIGH motif; other site 333849006255 nucleotide binding site [chemical binding]; other site 333849006256 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 333849006257 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 333849006258 active site 333849006259 KMSKS motif; other site 333849006260 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 333849006261 tRNA binding surface [nucleotide binding]; other site 333849006262 anticodon binding site; other site 333849006263 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 333849006264 T-box leader; HMPREF0351_nc10022 333849006265 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 333849006266 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 333849006267 CoA binding domain; Region: CoA_binding; pfam02629 333849006268 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 333849006269 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 333849006270 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 333849006271 Ligand Binding Site [chemical binding]; other site 333849006272 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 333849006273 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 333849006274 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 333849006275 catalytic residue [active] 333849006276 Septation ring formation regulator, EzrA; Region: EzrA; pfam06160 333849006277 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4696 333849006278 metal binding site [ion binding]; metal-binding site 333849006279 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 333849006280 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 333849006281 active site 333849006282 motif I; other site 333849006283 motif II; other site 333849006284 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 333849006285 Protein of unknown function DUF72; Region: DUF72; pfam01904 333849006286 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 333849006287 active site 333849006288 homotetramer interface [polypeptide binding]; other site 333849006289 homodimer interface [polypeptide binding]; other site 333849006290 Acyl-ACP thioesterase; Region: Acyl-ACP_TE; pfam01643 333849006291 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 333849006292 active site 333849006293 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 333849006294 active site 2 [active] 333849006295 Phosphotransferase enzyme family; Region: APH; pfam01636 333849006296 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 333849006297 active site 333849006298 ATP binding site [chemical binding]; other site 333849006299 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 333849006300 substrate binding site [chemical binding]; other site 333849006301 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 333849006302 trimer interface [polypeptide binding]; other site 333849006303 active site 333849006304 G bulge; other site 333849006305 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 333849006306 Serine hydrolase; Region: Ser_hydrolase; cl17834 333849006307 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4918 333849006308 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 333849006309 Transposase; Region: HTH_Tnp_1; pfam01527 333849006310 potential frameshift: common BLAST hit: gi|346716404|ref|YP_004849411.1| transposase 333849006311 Integrase core domain; Region: rve; pfam00665 333849006312 DDE domain; Region: DDE_Tnp_IS240; pfam13610 333849006313 Integrase core domain; Region: rve_2; pfam13333 333849006314 Predicted RNA binding protein (contains ribosomal protein S1 domain) [Translation, ribosomal structure and biogenesis]; Region: VacB; COG1098 333849006315 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 333849006316 RNA binding site [nucleotide binding]; other site 333849006317 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 333849006318 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 333849006319 pyridoxal 5'-phosphate binding site [chemical binding]; other site 333849006320 homodimer interface [polypeptide binding]; other site 333849006321 catalytic residue [active] 333849006322 Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family [Posttranslational modification, protein turnover, chaperones]; Region: PpiB; COG0652 333849006323 active site 333849006324 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 333849006325 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 333849006326 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 333849006327 tetramer interfaces [polypeptide binding]; other site 333849006328 binuclear metal-binding site [ion binding]; other site 333849006329 Protein of unknown function (DUF1461); Region: DUF1461; pfam07314 333849006330 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 333849006331 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 333849006332 active site 333849006333 motif I; other site 333849006334 motif II; other site 333849006335 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 333849006336 Protein of unknown function (DUF1027); Region: DUF1027; pfam06265 333849006337 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 333849006338 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 333849006339 active site 333849006340 metal binding site [ion binding]; metal-binding site 333849006341 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 333849006342 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 333849006343 nucleoside/Zn binding site; other site 333849006344 dimer interface [polypeptide binding]; other site 333849006345 catalytic motif [active] 333849006346 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 333849006347 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 333849006348 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 333849006349 S-adenosylmethionine binding site [chemical binding]; other site 333849006350 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 333849006351 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 333849006352 Mga helix-turn-helix domain; Region: Mga; pfam05043 333849006353 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298 333849006354 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 333849006355 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 333849006356 PhnA protein; Region: PhnA; pfam03831 333849006357 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 333849006358 DHH family; Region: DHH; pfam01368 333849006359 DHHA1 domain; Region: DHHA1; pfam02272 333849006360 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 333849006361 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 333849006362 DNA-binding site [nucleotide binding]; DNA binding site 333849006363 DRTGG domain; Region: DRTGG; pfam07085 333849006364 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 333849006365 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 333849006366 active site 2 [active] 333849006367 active site 1 [active] 333849006368 metal-dependent hydrolase; Provisional; Region: PRK00685 333849006369 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 333849006370 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 333849006371 putative deacylase active site [active] 333849006372 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 333849006373 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 333849006374 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 333849006375 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 333849006376 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 333849006377 FtsX-like permease family; Region: FtsX; pfam02687 333849006378 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 333849006379 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 333849006380 Walker A/P-loop; other site 333849006381 ATP binding site [chemical binding]; other site 333849006382 Q-loop/lid; other site 333849006383 ABC transporter signature motif; other site 333849006384 Walker B; other site 333849006385 D-loop; other site 333849006386 H-loop/switch region; other site 333849006387 CsbD-like; Region: CsbD; cl17424 333849006388 Isoaspartyl dipeptidase hydrolyzes the beta-L-isoaspartyl linkages in dipeptides, as part of the degradative pathway to eliminate proteins with beta-L-isoaspartyl peptide bonds, bonds whereby the beta-group of an aspartate forms the peptide link with the...; Region: Isoaspartyl-dipeptidase; cd01308 333849006389 isoaspartyl dipeptidase; Provisional; Region: PRK10657 333849006390 dimer interface [polypeptide binding]; other site 333849006391 active site 333849006392 Predicted membrane protein [Function unknown]; Region: COG1288; cl17886 333849006393 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 333849006394 hypothetical protein; Provisional; Region: PRK11588 333849006395 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 333849006396 putative active site [active] 333849006397 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 333849006398 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 333849006399 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 333849006400 active site 333849006401 tetramer interface; other site 333849006402 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 333849006403 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 333849006404 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 333849006405 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 333849006406 A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710 333849006407 putative active site [active] 333849006408 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 333849006409 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 333849006410 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 333849006411 dimer interface [polypeptide binding]; other site 333849006412 active site 333849006413 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 333849006414 dimer interface [polypeptide binding]; other site 333849006415 active site 333849006416 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 333849006417 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 333849006418 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 333849006419 active site 333849006420 phosphorylation site [posttranslational modification] 333849006421 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 333849006422 active pocket/dimerization site; other site 333849006423 active site 333849006424 phosphorylation site [posttranslational modification] 333849006425 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 333849006426 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 333849006427 Walker A motif; other site 333849006428 ATP binding site [chemical binding]; other site 333849006429 Walker B motif; other site 333849006430 arginine finger; other site 333849006431 Transcriptional antiterminator [Transcription]; Region: COG3933 333849006432 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 333849006433 active pocket/dimerization site; other site 333849006434 active site 333849006435 phosphorylation site [posttranslational modification] 333849006436 PRD domain; Region: PRD; pfam00874 333849006437 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 333849006438 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 333849006439 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 333849006440 Walker A/P-loop; other site 333849006441 ATP binding site [chemical binding]; other site 333849006442 Q-loop/lid; other site 333849006443 ABC transporter signature motif; other site 333849006444 Walker B; other site 333849006445 D-loop; other site 333849006446 H-loop/switch region; other site 333849006447 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 333849006448 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 333849006449 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 333849006450 Walker A/P-loop; other site 333849006451 ATP binding site [chemical binding]; other site 333849006452 Q-loop/lid; other site 333849006453 ABC transporter signature motif; other site 333849006454 Walker B; other site 333849006455 D-loop; other site 333849006456 H-loop/switch region; other site 333849006457 hypothetical protein; Provisional; Region: PRK09609 333849006458 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 333849006459 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 333849006460 active site 333849006461 dimer interfaces [polypeptide binding]; other site 333849006462 catalytic residues [active] 333849006463 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 333849006464 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 333849006465 Walker A/P-loop; other site 333849006466 ATP binding site [chemical binding]; other site 333849006467 Q-loop/lid; other site 333849006468 ABC transporter signature motif; other site 333849006469 Walker B; other site 333849006470 D-loop; other site 333849006471 H-loop/switch region; other site 333849006472 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 333849006473 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 333849006474 S-adenosylmethionine binding site [chemical binding]; other site 333849006475 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 333849006476 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 333849006477 putative active site [active] 333849006478 putative metal binding site [ion binding]; other site 333849006479 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 333849006480 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 333849006481 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 333849006482 active site 333849006483 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 333849006484 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 333849006485 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 333849006486 active site 333849006487 HIGH motif; other site 333849006488 KMSKS motif; other site 333849006489 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 333849006490 tRNA binding surface [nucleotide binding]; other site 333849006491 anticodon binding site; other site 333849006492 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 333849006493 dimer interface [polypeptide binding]; other site 333849006494 putative tRNA-binding site [nucleotide binding]; other site 333849006495 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 333849006496 nudix motif; other site 333849006497 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 333849006498 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 333849006499 Probable transposase; Region: OrfB_IS605; pfam01385 333849006500 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 333849006501 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 333849006502 Walker A/P-loop; other site 333849006503 ATP binding site [chemical binding]; other site 333849006504 Q-loop/lid; other site 333849006505 ABC transporter signature motif; other site 333849006506 Walker B; other site 333849006507 D-loop; other site 333849006508 H-loop/switch region; other site 333849006509 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 333849006510 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 333849006511 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 333849006512 Walker A/P-loop; other site 333849006513 ATP binding site [chemical binding]; other site 333849006514 Q-loop/lid; other site 333849006515 ABC transporter signature motif; other site 333849006516 Walker B; other site 333849006517 D-loop; other site 333849006518 H-loop/switch region; other site 333849006519 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 333849006520 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 333849006521 dipeptide transporter; Provisional; Region: PRK10913 333849006522 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 333849006523 dimer interface [polypeptide binding]; other site 333849006524 conserved gate region; other site 333849006525 putative PBP binding loops; other site 333849006526 ABC-ATPase subunit interface; other site 333849006527 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 333849006528 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 333849006529 dimer interface [polypeptide binding]; other site 333849006530 conserved gate region; other site 333849006531 putative PBP binding loops; other site 333849006532 ABC-ATPase subunit interface; other site 333849006533 Domain of unknown function (DUF3899); Region: DUF3899; pfam13038 333849006534 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 333849006535 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 333849006536 peptide binding site [polypeptide binding]; other site 333849006537 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 333849006538 Coenzyme A binding pocket [chemical binding]; other site 333849006539 Glycerol dehydrogenase-like; Region: GlyDH-like2; cd08171 333849006540 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 333849006541 putative active site [active] 333849006542 metal binding site [ion binding]; metal-binding site 333849006543 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 333849006544 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 333849006545 FeS/SAM binding site; other site 333849006546 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 333849006547 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 333849006548 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 333849006549 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 333849006550 beta-galactosidase; Region: BGL; TIGR03356 333849006551 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 333849006552 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 333849006553 substrate binding pocket [chemical binding]; other site 333849006554 membrane-bound complex binding site; other site 333849006555 hinge residues; other site 333849006556 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 333849006557 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 333849006558 Walker A/P-loop; other site 333849006559 ATP binding site [chemical binding]; other site 333849006560 Q-loop/lid; other site 333849006561 ABC transporter signature motif; other site 333849006562 Walker B; other site 333849006563 D-loop; other site 333849006564 H-loop/switch region; other site 333849006565 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 333849006566 dimer interface [polypeptide binding]; other site 333849006567 conserved gate region; other site 333849006568 putative PBP binding loops; other site 333849006569 ABC-ATPase subunit interface; other site 333849006570 This CD includes bacterial (Agrobacterium tumefaciens and Caulobacter crescentus ProX, and Clostridium sticklandii PrdX) and eukaryotic (Plasmodium falciparum N-terminal ProRS editing domain) sequences. The C. sticklandii PrdX protein, a homolog of the...; Region: PrdX_deacylase; cd04335 333849006571 putative deacylase active site [active] 333849006572 Collagen binding domain; Region: Collagen_bind; pfam05737 333849006573 Cna protein B-type domain; Region: Cna_B; pfam05738 333849006574 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 333849006575 domain interaction interfaces [polypeptide binding]; other site 333849006576 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 333849006577 domain interaction interfaces [polypeptide binding]; other site 333849006578 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 333849006579 Enterocin A Immunity; Region: EntA_Immun; pfam08951 333849006580 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 333849006581 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 333849006582 CAAX protease self-immunity; Region: Abi; cl00558 333849006583 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 333849006584 active site 333849006585 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 333849006586 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 333849006587 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 333849006588 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 333849006589 dimer interface [polypeptide binding]; other site 333849006590 active site 333849006591 glycine-pyridoxal phosphate binding site [chemical binding]; other site 333849006592 folate binding site [chemical binding]; other site 333849006593 potential frameshift: common BLAST hit: gi|383329618|ref|YP_005355502.1| Sua5/YciO/YrdC/YwlC family protein 333849006594 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 333849006595 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 333849006596 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 333849006597 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 333849006598 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 333849006599 peptide chain release factor 1; Validated; Region: prfA; PRK00591 333849006600 This domain is found in peptide chain release factors; Region: PCRF; smart00937 333849006601 RF-1 domain; Region: RF-1; pfam00472 333849006602 thymidine kinase; Provisional; Region: PRK04296 333849006603 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 333849006604 ATP binding site [chemical binding]; other site 333849006605 Walker A motif; other site 333849006606 Walker B motif; other site 333849006607 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 333849006608 Coenzyme A binding pocket [chemical binding]; other site 333849006609 Methyltransferase domain; Region: Methyltransf_23; pfam13489 333849006610 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 333849006611 S-adenosylmethionine binding site [chemical binding]; other site 333849006612 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 333849006613 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 333849006614 Catalytic site [active] 333849006615 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 333849006616 Uncharacterized BCR, COG1636; Region: DUF208; pfam02677 333849006617 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 333849006618 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 333849006619 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 333849006620 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 333849006621 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 333849006622 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 333849006623 catalytic triad [active] 333849006624 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 333849006625 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 333849006626 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 333849006627 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 333849006628 active site 333849006629 phosphorylation site [posttranslational modification] 333849006630 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 333849006631 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 333849006632 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 333849006633 active site 333849006634 P-loop; other site 333849006635 phosphorylation site [posttranslational modification] 333849006636 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 333849006637 active site 333849006638 P-loop; other site 333849006639 phosphorylation site [posttranslational modification] 333849006640 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 333849006641 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 333849006642 Walker A/P-loop; other site 333849006643 ATP binding site [chemical binding]; other site 333849006644 Q-loop/lid; other site 333849006645 ABC transporter signature motif; other site 333849006646 Walker B; other site 333849006647 D-loop; other site 333849006648 H-loop/switch region; other site 333849006649 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 333849006650 active site 333849006651 phosphorylation site [posttranslational modification] 333849006652 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 333849006653 HTH domain; Region: HTH_11; pfam08279 333849006654 HTH domain; Region: HTH_11; pfam08279 333849006655 PRD domain; Region: PRD; pfam00874 333849006656 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 333849006657 P-loop; other site 333849006658 active site 333849006659 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 333849006660 active site 333849006661 phosphorylation site [posttranslational modification] 333849006662 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 333849006663 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 333849006664 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 333849006665 active site 333849006666 P-loop; other site 333849006667 phosphorylation site [posttranslational modification] 333849006668 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 333849006669 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 333849006670 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 333849006671 Beta-lactamase; Region: Beta-lactamase; pfam00144 333849006672 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 333849006673 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 333849006674 active site 333849006675 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 333849006676 active site 333849006677 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 333849006678 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 333849006679 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 333849006680 Walker A/P-loop; other site 333849006681 ATP binding site [chemical binding]; other site 333849006682 Q-loop/lid; other site 333849006683 ABC transporter signature motif; other site 333849006684 Walker B; other site 333849006685 D-loop; other site 333849006686 H-loop/switch region; other site 333849006687 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 333849006688 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 333849006689 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 333849006690 Walker A/P-loop; other site 333849006691 ATP binding site [chemical binding]; other site 333849006692 Q-loop/lid; other site 333849006693 ABC transporter signature motif; other site 333849006694 Walker B; other site 333849006695 D-loop; other site 333849006696 H-loop/switch region; other site 333849006697 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 333849006698 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 333849006699 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 333849006700 active site residue [active] 333849006701 azoreductase; Reviewed; Region: PRK00170 333849006702 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 333849006703 Domain of unknown function DUF20; Region: UPF0118; pfam01594 333849006704 PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; cl01516 333849006705 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 333849006706 Sulfatase; Region: Sulfatase; pfam00884 333849006707 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_3; cd12174 333849006708 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 333849006709 putative ligand binding site [chemical binding]; other site 333849006710 putative NAD binding site [chemical binding]; other site 333849006711 putative catalytic site [active] 333849006712 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 333849006713 L-arabinose isomerase; Provisional; Region: PRK02929 333849006714 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 333849006715 hexamer (dimer of trimers) interface [polypeptide binding]; other site 333849006716 trimer interface [polypeptide binding]; other site 333849006717 substrate binding site [chemical binding]; other site 333849006718 Mn binding site [ion binding]; other site 333849006719 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 333849006720 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 333849006721 intersubunit interface [polypeptide binding]; other site 333849006722 active site 333849006723 Zn2+ binding site [ion binding]; other site 333849006724 L-ribulokinase-like proteins; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-RBK_like; cd07778 333849006725 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 333849006726 putative N- and C-terminal domain interface [polypeptide binding]; other site 333849006727 putative active site [active] 333849006728 MgATP binding site [chemical binding]; other site 333849006729 catalytic site [active] 333849006730 metal binding site [ion binding]; metal-binding site 333849006731 putative carbohydrate binding site [chemical binding]; other site 333849006732 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 333849006733 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 333849006734 putative substrate translocation pore; other site 333849006735 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 333849006736 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 333849006737 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 333849006738 DNA-binding site [nucleotide binding]; DNA binding site 333849006739 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 333849006740 Ligand-binding domain of DNA transcription repressor specific for arabinose (AraR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AraR; cd01541 333849006741 putative dimerization interface [polypeptide binding]; other site 333849006742 putative ligand binding site [chemical binding]; other site 333849006743 Glycosyl hydrolase family 43; Region: GH43_1; cd08980 333849006744 active site 333849006745 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 333849006746 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; smart00813 333849006747 Protein of unknown function, DUF624; Region: DUF624; pfam04854 333849006748 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 333849006749 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 333849006750 dimer interface [polypeptide binding]; other site 333849006751 conserved gate region; other site 333849006752 putative PBP binding loops; other site 333849006753 ABC-ATPase subunit interface; other site 333849006754 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 333849006755 dimer interface [polypeptide binding]; other site 333849006756 conserved gate region; other site 333849006757 putative PBP binding loops; other site 333849006758 ABC-ATPase subunit interface; other site 333849006759 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 333849006760 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 333849006761 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 333849006762 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 333849006763 Predicted transcriptional regulator [Transcription]; Region: COG4189 333849006764 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 333849006765 putative DNA binding site [nucleotide binding]; other site 333849006766 dimerization interface [polypeptide binding]; other site 333849006767 putative Zn2+ binding site [ion binding]; other site 333849006768 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 333849006769 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 333849006770 homodimer interface [polypeptide binding]; other site 333849006771 NAD binding pocket [chemical binding]; other site 333849006772 ATP binding pocket [chemical binding]; other site 333849006773 Mg binding site [ion binding]; other site 333849006774 active-site loop [active] 333849006775 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 333849006776 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 333849006777 active site 333849006778 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 333849006779 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 333849006780 DNA binding residues [nucleotide binding] 333849006781 dimer interface [polypeptide binding]; other site 333849006782 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 333849006783 Transcriptional regulators [Transcription]; Region: PurR; COG1609 333849006784 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 333849006785 DNA binding site [nucleotide binding] 333849006786 domain linker motif; other site 333849006787 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 333849006788 putative ligand binding site [chemical binding]; other site 333849006789 putative dimerization interface [polypeptide binding]; other site 333849006790 Transposase, Mutator family; Region: Transposase_mut; pfam00872 333849006791 MULE transposase domain; Region: MULE; pfam10551 333849006792 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 333849006793 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 333849006794 ring oligomerisation interface [polypeptide binding]; other site 333849006795 ATP/Mg binding site [chemical binding]; other site 333849006796 stacking interactions; other site 333849006797 hinge regions; other site 333849006798 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 333849006799 oligomerisation interface [polypeptide binding]; other site 333849006800 mobile loop; other site 333849006801 roof hairpin; other site 333849006802 CAAX protease self-immunity; Region: Abi; pfam02517 333849006803 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 333849006804 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 333849006805 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 333849006806 NADH(P)-binding; Region: NAD_binding_10; pfam13460 333849006807 NAD binding site [chemical binding]; other site 333849006808 substrate binding site [chemical binding]; other site 333849006809 putative active site [active] 333849006810 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 333849006811 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 333849006812 YycH protein; Region: YycI; pfam09648 333849006813 YycH protein; Region: YycH; pfam07435 333849006814 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863 333849006815 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 333849006816 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 333849006817 dimerization interface [polypeptide binding]; other site 333849006818 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 333849006819 putative active site [active] 333849006820 heme pocket [chemical binding]; other site 333849006821 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 333849006822 dimer interface [polypeptide binding]; other site 333849006823 phosphorylation site [posttranslational modification] 333849006824 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 333849006825 ATP binding site [chemical binding]; other site 333849006826 Mg2+ binding site [ion binding]; other site 333849006827 G-X-G motif; other site 333849006828 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 333849006829 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 333849006830 active site 333849006831 phosphorylation site [posttranslational modification] 333849006832 intermolecular recognition site; other site 333849006833 dimerization interface [polypeptide binding]; other site 333849006834 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 333849006835 DNA binding site [nucleotide binding] 333849006836 EDD domain protein, DegV family; Region: DegV; TIGR00762 333849006837 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 333849006838 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 333849006839 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 333849006840 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 333849006841 Helix-turn-helix domain; Region: HTH_38; pfam13936 333849006842 Integrase core domain; Region: rve; pfam00665 333849006843 Integrase core domain; Region: rve_3; cl15866 333849006844 Enterocin A Immunity; Region: EntA_Immun; pfam08951 333849006845 Class II bacteriocin; Region: Bacteriocin_II; pfam01721 333849006846 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 333849006847 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 333849006848 dimer interface [polypeptide binding]; other site 333849006849 conserved gate region; other site 333849006850 putative PBP binding loops; other site 333849006851 ABC-ATPase subunit interface; other site 333849006852 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 333849006853 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 333849006854 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 333849006855 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 333849006856 Walker A/P-loop; other site 333849006857 ATP binding site [chemical binding]; other site 333849006858 Q-loop/lid; other site 333849006859 ABC transporter signature motif; other site 333849006860 Walker B; other site 333849006861 D-loop; other site 333849006862 H-loop/switch region; other site 333849006863 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 333849006864 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 333849006865 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 333849006866 DNA-binding site [nucleotide binding]; DNA binding site 333849006867 TrkA-C domain; Region: TrkA_C; pfam02080 333849006868 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 333849006869 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 333849006870 G1 box; other site 333849006871 GTP/Mg2+ binding site [chemical binding]; other site 333849006872 Switch I region; other site 333849006873 G2 box; other site 333849006874 G3 box; other site 333849006875 Switch II region; other site 333849006876 G4 box; other site 333849006877 G5 box; other site 333849006878 Nucleoside recognition; Region: Gate; pfam07670 333849006879 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 333849006880 Nucleoside recognition; Region: Gate; pfam07670 333849006881 FeoA domain; Region: FeoA; pfam04023 333849006882 Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918 333849006883 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 333849006884 catalytic residues [active] 333849006885 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07306 333849006886 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 333849006887 Class I ribonucleotide reductase; Region: RNR_I; cd01679 333849006888 active site 333849006889 dimer interface [polypeptide binding]; other site 333849006890 catalytic residues [active] 333849006891 effector binding site; other site 333849006892 R2 peptide binding site; other site 333849006893 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 333849006894 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 333849006895 dimer interface [polypeptide binding]; other site 333849006896 putative radical transfer pathway; other site 333849006897 diiron center [ion binding]; other site 333849006898 tyrosyl radical; other site 333849006899 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 333849006900 Domain of unknown function DUF20; Region: UPF0118; pfam01594 333849006901 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 333849006902 MgtC family; Region: MgtC; pfam02308 333849006903 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 333849006904 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 333849006905 active site 333849006906 trimer interface [polypeptide binding]; other site 333849006907 allosteric site; other site 333849006908 active site lid [active] 333849006909 hexamer (dimer of trimers) interface [polypeptide binding]; other site 333849006910 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 333849006911 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 333849006912 Walker A/P-loop; other site 333849006913 ATP binding site [chemical binding]; other site 333849006914 Q-loop/lid; other site 333849006915 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 333849006916 ABC transporter signature motif; other site 333849006917 Walker B; other site 333849006918 D-loop; other site 333849006919 ABC transporter; Region: ABC_tran_2; pfam12848 333849006920 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 333849006921 potential frameshift: common BLAST hit: gi|383329763|ref|YP_005355647.1| ISEfm1, transposase 333849006922 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 333849006923 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 333849006924 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 333849006925 Major Facilitator Superfamily; Region: MFS_1; pfam07690 333849006926 putative substrate translocation pore; other site 333849006927 Uncharacterized conserved protein [Function unknown]; Region: COG0398 333849006928 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 333849006929 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 333849006930 core dimer interface [polypeptide binding]; other site 333849006931 peripheral dimer interface [polypeptide binding]; other site 333849006932 L10 interface [polypeptide binding]; other site 333849006933 L11 interface [polypeptide binding]; other site 333849006934 putative EF-Tu interaction site [polypeptide binding]; other site 333849006935 putative EF-G interaction site [polypeptide binding]; other site 333849006936 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 333849006937 23S rRNA interface [nucleotide binding]; other site 333849006938 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 333849006939 ribosomal protein L10 leader; HMPREF0351_nc10025 333849006940 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 333849006941 mRNA/rRNA interface [nucleotide binding]; other site 333849006942 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 333849006943 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 333849006944 23S rRNA interface [nucleotide binding]; other site 333849006945 L7/L12 interface [polypeptide binding]; other site 333849006946 putative thiostrepton binding site; other site 333849006947 L25 interface [polypeptide binding]; other site 333849006948 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 333849006949 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 333849006950 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 333849006951 putative L-serine binding site [chemical binding]; other site 333849006952 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 333849006953 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 333849006954 L-Lactate oxidase (LOX) FMN-binding domain. LOX is a member of the family of FMN-containing alpha-hydroxyacid oxidases and catalyzes the oxidation of l-lactate using molecular oxygen to generate pyruvate and H2O2. This family occurs in both prokaryotes...; Region: LOX_like_FMN; cd04737 333849006955 active site 333849006956 teramer interface [polypeptide binding]; other site 333849006957 FMN binding site [chemical binding]; other site 333849006958 catalytic residues [active] 333849006959 Uncharacterized protein with an alpha/beta hydrolase fold [General function prediction only]; Region: COG4814 333849006960 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 333849006961 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 333849006962 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 333849006963 putative homodimer interface [polypeptide binding]; other site 333849006964 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 333849006965 heterodimer interface [polypeptide binding]; other site 333849006966 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 333849006967 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 333849006968 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 333849006969 QueT transporter; Region: QueT; pfam06177 333849006970 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 333849006971 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 333849006972 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 333849006973 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 333849006974 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 333849006975 Walker A/P-loop; other site 333849006976 ATP binding site [chemical binding]; other site 333849006977 Q-loop/lid; other site 333849006978 ABC transporter signature motif; other site 333849006979 Walker B; other site 333849006980 D-loop; other site 333849006981 H-loop/switch region; other site 333849006982 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 333849006983 Histidine kinase; Region: HisKA_3; pfam07730 333849006984 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 333849006985 ATP binding site [chemical binding]; other site 333849006986 Mg2+ binding site [ion binding]; other site 333849006987 G-X-G motif; other site 333849006988 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 333849006989 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 333849006990 active site 333849006991 phosphorylation site [posttranslational modification] 333849006992 intermolecular recognition site; other site 333849006993 dimerization interface [polypeptide binding]; other site 333849006994 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 333849006995 DNA binding residues [nucleotide binding] 333849006996 dimerization interface [polypeptide binding]; other site 333849006997 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 333849006998 AAA domain; Region: AAA_30; pfam13604 333849006999 Family description; Region: UvrD_C_2; pfam13538 333849007000 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 333849007001 catalytic core [active] 333849007002 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 333849007003 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 333849007004 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 333849007005 S-adenosylmethionine binding site [chemical binding]; other site 333849007006 Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142 333849007007 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 333849007008 MgtE intracellular N domain; Region: MgtE_N; pfam03448 333849007009 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 333849007010 Divalent cation transporter; Region: MgtE; pfam01769 333849007011 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 333849007012 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 333849007013 active site 333849007014 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 333849007015 ATP-NAD kinase; Region: NAD_kinase; pfam01513 333849007016 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 333849007017 synthetase active site [active] 333849007018 NTP binding site [chemical binding]; other site 333849007019 metal binding site [ion binding]; metal-binding site 333849007020 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 333849007021 putative active site [active] 333849007022 putative metal binding residues [ion binding]; other site 333849007023 signature motif; other site 333849007024 putative triphosphate binding site [ion binding]; other site 333849007025 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 333849007026 catalytic residues [active] 333849007027 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 333849007028 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 333849007029 Homeodomain-like domain; Region: HTH_23; pfam13384 333849007030 Transposase; Region: DDE_Tnp_ISL3; pfam01610 333849007031 Oligoendopeptidase F [Amino acid transport and metabolism]; Region: COG1164 333849007032 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 333849007033 active site 333849007034 Zn binding site [ion binding]; other site 333849007035 Competence protein CoiA-like family; Region: CoiA; cl11541 333849007036 Negative regulator of genetic competence (MecA); Region: MecA; pfam05389 333849007037 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 333849007038 ArsC family; Region: ArsC; pfam03960 333849007039 putative catalytic residues [active] 333849007040 thiol/disulfide switch; other site 333849007041 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 333849007042 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 333849007043 active site 333849007044 motif I; other site 333849007045 motif II; other site 333849007046 SWIM zinc finger; Region: SWIM; pfam04434 333849007047 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 333849007048 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 333849007049 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 333849007050 ATP binding site [chemical binding]; other site 333849007051 putative Mg++ binding site [ion binding]; other site 333849007052 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 333849007053 nucleotide binding region [chemical binding]; other site 333849007054 ATP-binding site [chemical binding]; other site 333849007055 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 333849007056 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 333849007057 Walker A/P-loop; other site 333849007058 ATP binding site [chemical binding]; other site 333849007059 Q-loop/lid; other site 333849007060 ABC transporter signature motif; other site 333849007061 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 333849007062 ABC transporter signature motif; other site 333849007063 Walker B; other site 333849007064 D-loop; other site 333849007065 H-loop/switch region; other site 333849007066 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 333849007067 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 333849007068 active site 333849007069 metal binding site [ion binding]; metal-binding site 333849007070 DNA binding site [nucleotide binding] 333849007071 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 333849007072 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 333849007073 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 333849007074 putative acyl-acceptor binding pocket; other site 333849007075 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 333849007076 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 333849007077 S-adenosylmethionine binding site [chemical binding]; other site 333849007078 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 333849007079 GIY-YIG motif/motif A; other site 333849007080 putative active site [active] 333849007081 putative metal binding site [ion binding]; other site 333849007082 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 333849007083 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 333849007084 catalytic triad [active] 333849007085 catalytic triad [active] 333849007086 oxyanion hole [active] 333849007087 Uncharacterized conserved protein [Function unknown]; Region: COG1284 333849007088 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 333849007089 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 333849007090 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 333849007091 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 333849007092 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 333849007093 dimer interface [polypeptide binding]; other site 333849007094 anticodon binding site; other site 333849007095 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 333849007096 homodimer interface [polypeptide binding]; other site 333849007097 motif 1; other site 333849007098 active site 333849007099 motif 2; other site 333849007100 GAD domain; Region: GAD; pfam02938 333849007101 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 333849007102 motif 3; other site 333849007103 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 333849007104 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 333849007105 dimer interface [polypeptide binding]; other site 333849007106 motif 1; other site 333849007107 active site 333849007108 motif 2; other site 333849007109 motif 3; other site 333849007110 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 333849007111 anticodon binding site; other site 333849007112 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 333849007113 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 333849007114 active site 333849007115 catalytic tetrad [active] 333849007116 Cytochrome P450; Region: p450; cl12078 333849007117 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 333849007118 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 333849007119 putative active site [active] 333849007120 dimerization interface [polypeptide binding]; other site 333849007121 putative tRNAtyr binding site [nucleotide binding]; other site 333849007122 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 333849007123 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 333849007124 Zn2+ binding site [ion binding]; other site 333849007125 Mg2+ binding site [ion binding]; other site 333849007126 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 333849007127 synthetase active site [active] 333849007128 NTP binding site [chemical binding]; other site 333849007129 metal binding site [ion binding]; metal-binding site 333849007130 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 333849007131 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 333849007132 RNA methyltransferase, RsmE family; Region: TIGR00046 333849007133 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 333849007134 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 333849007135 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 333849007136 S-adenosylmethionine binding site [chemical binding]; other site 333849007137 Protein of unknown function (DUF3013); Region: DUF3013; pfam11217 333849007138 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 333849007139 active site 333849007140 DNA binding site [nucleotide binding] 333849007141 recombination factor protein RarA; Reviewed; Region: PRK13342 333849007142 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 333849007143 Walker A motif; other site 333849007144 ATP binding site [chemical binding]; other site 333849007145 Walker B motif; other site 333849007146 arginine finger; other site 333849007147 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 333849007148 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 333849007149 Ligand Binding Site [chemical binding]; other site 333849007150 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 333849007151 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 333849007152 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 333849007153 ABC transporter; Region: ABC_tran_2; pfam12848 333849007154 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 333849007155 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 333849007156 propionate/acetate kinase; Provisional; Region: PRK12379 333849007157 nucleotide binding site [chemical binding]; other site 333849007158 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 333849007159 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 333849007160 S-adenosylmethionine binding site [chemical binding]; other site 333849007161 Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940 333849007162 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 333849007163 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 333849007164 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 333849007165 Type II/IV secretion system protein; Region: T2SE; pfam00437 333849007166 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 333849007167 Walker A motif; other site 333849007168 ATP binding site [chemical binding]; other site 333849007169 Walker B motif; other site 333849007170 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 333849007171 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 333849007172 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 333849007173 active site 333849007174 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 333849007175 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 333849007176 S-adenosylmethionine binding site [chemical binding]; other site 333849007177 Phosphotransferase enzyme family; Region: APH; pfam01636 333849007178 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 333849007179 active site 333849007180 substrate binding site [chemical binding]; other site 333849007181 ATP binding site [chemical binding]; other site 333849007182 Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975 333849007183 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 333849007184 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 333849007185 Walker A/P-loop; other site 333849007186 ATP binding site [chemical binding]; other site 333849007187 Q-loop/lid; other site 333849007188 ABC transporter signature motif; other site 333849007189 Walker B; other site 333849007190 D-loop; other site 333849007191 H-loop/switch region; other site 333849007192 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 333849007193 HIT family signature motif; other site 333849007194 catalytic residue [active] 333849007195 foldase protein PrsA; Reviewed; Region: prsA; PRK01326 333849007196 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 333849007197 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 333849007198 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 333849007199 generic binding surface II; other site 333849007200 generic binding surface I; other site 333849007201 integrating conjugative element relaxase, PFL_4751 family; Region: ICE_TraI_Pfluor; TIGR03760 333849007202 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 333849007203 Zn2+ binding site [ion binding]; other site 333849007204 Mg2+ binding site [ion binding]; other site 333849007205 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 333849007206 Walker A/P-loop; other site 333849007207 ATP binding site [chemical binding]; other site 333849007208 Dot/Icm secretion system protein (dot_icm_IcmQ); Region: Dot_icm_IcmQ; cl09711 333849007209 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 333849007210 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 333849007211 active site 333849007212 metal binding site [ion binding]; metal-binding site 333849007213 DNA binding site [nucleotide binding] 333849007214 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 333849007215 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 333849007216 active site 333849007217 motif I; other site 333849007218 motif II; other site 333849007219 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 333849007220 potential frameshift: common BLAST hit: gi|383329848|ref|YP_005355732.1| polygalacturonase 333849007221 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 333849007222 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 333849007223 MFS/sugar transport protein; Region: MFS_2; pfam13347 333849007224 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 333849007225 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 333849007226 inhibitor binding site; inhibition site 333849007227 active site 333849007228 putative pectinesterase; Region: PLN02432; cl01911 333849007229 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 333849007230 Glycosyl hydrolases family 28; Region: Glyco_hydro_28; pfam00295 333849007231 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 333849007232 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 333849007233 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 333849007234 Predicted integral membrane protein [Function unknown]; Region: COG5578 333849007235 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 333849007236 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 333849007237 dimer interface [polypeptide binding]; other site 333849007238 conserved gate region; other site 333849007239 ABC-ATPase subunit interface; other site 333849007240 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 333849007241 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 333849007242 dimer interface [polypeptide binding]; other site 333849007243 conserved gate region; other site 333849007244 putative PBP binding loops; other site 333849007245 ABC-ATPase subunit interface; other site 333849007246 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 333849007247 metal binding site [ion binding]; metal-binding site 333849007248 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 333849007249 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 333849007250 Transcriptional regulators [Transcription]; Region: PurR; COG1609 333849007251 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 333849007252 DNA binding site [nucleotide binding] 333849007253 domain linker motif; other site 333849007254 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 333849007255 dimerization interface [polypeptide binding]; other site 333849007256 ligand binding site [chemical binding]; other site 333849007257 altronate oxidoreductase; Provisional; Region: PRK03643 333849007258 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 333849007259 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 333849007260 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 333849007261 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 333849007262 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 333849007263 Glucuronate isomerase; Region: UxaC; pfam02614 333849007264 Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821 333849007265 active site 333849007266 catalytic triad [active] 333849007267 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 333849007268 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 333849007269 Metal-binding active site; metal-binding site 333849007270 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 333849007271 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 333849007272 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 333849007273 Walker A/P-loop; other site 333849007274 ATP binding site [chemical binding]; other site 333849007275 Q-loop/lid; other site 333849007276 ABC transporter signature motif; other site 333849007277 Walker B; other site 333849007278 D-loop; other site 333849007279 H-loop/switch region; other site 333849007280 hypothetical protein; Provisional; Region: PRK13676 333849007281 Transglycosylase; Region: Transgly; pfam00912 333849007282 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 333849007283 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 333849007284 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 333849007285 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 333849007286 active site 333849007287 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 333849007288 ROK family; Region: ROK; pfam00480 333849007289 nucleotide binding site [chemical binding]; other site 333849007290 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 333849007291 N-terminal catalytic domain of SPGH38, a putative alpha-mannosidase of Streptococcus pyogenes, and its prokaryotic homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_SpGH38_like; cd10814 333849007292 active site 333849007293 metal binding site [ion binding]; metal-binding site 333849007294 homodimer interface [polypeptide binding]; other site 333849007295 catalytic site [active] 333849007296 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 333849007297 Uncharacterized conserved protein [Function unknown]; Region: COG3538 333849007298 Protein of unknown function (DUF1237); Region: DUF1237; pfam06824 333849007299 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 333849007300 DNA-binding site [nucleotide binding]; DNA binding site 333849007301 Transcriptional regulators [Transcription]; Region: PurR; COG1609 333849007302 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 333849007303 ligand binding site [chemical binding]; other site 333849007304 dimerization interface [polypeptide binding]; other site 333849007305 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 333849007306 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 333849007307 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 333849007308 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 333849007309 active site 333849007310 phosphorylation site [posttranslational modification] 333849007311 intermolecular recognition site; other site 333849007312 dimerization interface [polypeptide binding]; other site 333849007313 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 333849007314 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 333849007315 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 333849007316 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 333849007317 dimerization interface [polypeptide binding]; other site 333849007318 Histidine kinase; Region: His_kinase; pfam06580 333849007319 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 333849007320 ATP binding site [chemical binding]; other site 333849007321 Mg2+ binding site [ion binding]; other site 333849007322 G-X-G motif; other site 333849007323 Protein of unknown function, DUF624; Region: DUF624; cl02369 333849007324 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 333849007325 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 333849007326 Domain of unknown function (DUF3502); Region: DUF3502; pfam12010 333849007327 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 333849007328 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 333849007329 dimer interface [polypeptide binding]; other site 333849007330 conserved gate region; other site 333849007331 putative PBP binding loops; other site 333849007332 ABC-ATPase subunit interface; other site 333849007333 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 333849007334 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 333849007335 dimer interface [polypeptide binding]; other site 333849007336 conserved gate region; other site 333849007337 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 333849007338 ABC-ATPase subunit interface; other site 333849007339 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 333849007340 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 333849007341 RNA binding surface [nucleotide binding]; other site 333849007342 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 333849007343 active site 333849007344 uracil binding [chemical binding]; other site 333849007345 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 333849007346 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 333849007347 Uncharacterized conserved protein [Function unknown]; Region: COG1284 333849007348 UDP-N-acetylmuramoylalanyl-D-glutamate--L-lysine ligase; Provisional; Region: PRK14022 333849007349 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 333849007350 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 333849007351 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 333849007352 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 333849007353 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 333849007354 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 333849007355 methionine cluster; other site 333849007356 active site 333849007357 phosphorylation site [posttranslational modification] 333849007358 metal binding site [ion binding]; metal-binding site 333849007359 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 333849007360 HTH domain; Region: HTH_11; pfam08279 333849007361 Mga helix-turn-helix domain; Region: Mga; pfam05043 333849007362 PRD domain; Region: PRD; pfam00874 333849007363 PRD domain; Region: PRD; pfam00874 333849007364 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 333849007365 active site 333849007366 P-loop; other site 333849007367 phosphorylation site [posttranslational modification] 333849007368 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 333849007369 active site 333849007370 phosphorylation site [posttranslational modification] 333849007371 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 333849007372 active site 333849007373 P-loop; other site 333849007374 phosphorylation site [posttranslational modification] 333849007375 Uncharacterized conserved protein [Function unknown]; Region: COG1359 333849007376 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 333849007377 potential frameshift: common BLAST hit: gi|383328808|ref|YP_005354692.1| ISL3 family transposase 333849007378 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 333849007379 Cna protein B-type domain; Region: Cna_B; pfam05738 333849007380 Cna protein B-type domain; Region: Cna_B; pfam05738 333849007381 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 333849007382 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 333849007383 Cna protein B-type domain; Region: Cna_B; pfam05738 333849007384 Cna protein B-type domain; Region: Cna_B; pfam05738 333849007385 Cna protein B-type domain; Region: Cna_B; pfam05738 333849007386 Cna protein B-type domain; Region: Cna_B; pfam05738 333849007387 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 333849007388 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 333849007389 DNA binding residues [nucleotide binding] 333849007390 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 333849007391 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 333849007392 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 333849007393 Walker A/P-loop; other site 333849007394 ATP binding site [chemical binding]; other site 333849007395 Q-loop/lid; other site 333849007396 ABC transporter signature motif; other site 333849007397 Walker B; other site 333849007398 D-loop; other site 333849007399 H-loop/switch region; other site 333849007400 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 333849007401 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 333849007402 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 333849007403 Walker A/P-loop; other site 333849007404 ATP binding site [chemical binding]; other site 333849007405 Q-loop/lid; other site 333849007406 ABC transporter signature motif; other site 333849007407 Walker B; other site 333849007408 D-loop; other site 333849007409 H-loop/switch region; other site 333849007410 BNR repeat-like domain; Region: BNR_2; pfam13088 333849007411 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 333849007412 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 333849007413 HIGH motif; other site 333849007414 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 333849007415 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 333849007416 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 333849007417 active site 333849007418 KMSKS motif; other site 333849007419 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 333849007420 tRNA binding surface [nucleotide binding]; other site 333849007421 T-box leader; HMPREF0351_nc10029 333849007422 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 333849007423 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 333849007424 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 333849007425 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 333849007426 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 333849007427 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 333849007428 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 333849007429 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 333849007430 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 333849007431 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 333849007432 active site 333849007433 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 333849007434 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 333849007435 Putative rRNA methylase; Region: rRNA_methylase; pfam06962 333849007436 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 333849007437 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 333849007438 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 333849007439 Walker A/P-loop; other site 333849007440 ATP binding site [chemical binding]; other site 333849007441 Q-loop/lid; other site 333849007442 ABC transporter signature motif; other site 333849007443 Walker B; other site 333849007444 D-loop; other site 333849007445 H-loop/switch region; other site 333849007446 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 333849007447 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 333849007448 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 333849007449 Walker A/P-loop; other site 333849007450 ATP binding site [chemical binding]; other site 333849007451 Q-loop/lid; other site 333849007452 ABC transporter signature motif; other site 333849007453 Walker B; other site 333849007454 D-loop; other site 333849007455 H-loop/switch region; other site 333849007456 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 333849007457 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 333849007458 Putative esterase; Region: Esterase; pfam00756 333849007459 S-formylglutathione hydrolase; Region: PLN02442 333849007460 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 333849007461 Major Facilitator Superfamily; Region: MFS_1; pfam07690 333849007462 putative substrate translocation pore; other site 333849007463 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 333849007464 S-adenosylmethionine synthetase; Validated; Region: PRK05250 333849007465 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 333849007466 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 333849007467 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 333849007468 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 333849007469 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 333849007470 dimer interface [polypeptide binding]; other site 333849007471 putative anticodon binding site; other site 333849007472 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 333849007473 motif 1; other site 333849007474 active site 333849007475 motif 2; other site 333849007476 motif 3; other site 333849007477 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 333849007478 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 333849007479 FMN binding site [chemical binding]; other site 333849007480 active site 333849007481 catalytic residues [active] 333849007482 substrate binding site [chemical binding]; other site 333849007483 potential frameshift: common BLAST hit: gi|383329912|ref|YP_005355796.1| chaperonin HslO 333849007484 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 333849007485 dimerization interface [polypeptide binding]; other site 333849007486 domain crossover interface; other site 333849007487 redox-dependent activation switch; other site 333849007488 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 333849007489 FtsH Extracellular; Region: FtsH_ext; pfam06480 333849007490 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 333849007491 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 333849007492 Walker A motif; other site 333849007493 ATP binding site [chemical binding]; other site 333849007494 Walker B motif; other site 333849007495 arginine finger; other site 333849007496 Peptidase family M41; Region: Peptidase_M41; pfam01434 333849007497 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 333849007498 active site 333849007499 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 333849007500 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 333849007501 Ligand Binding Site [chemical binding]; other site 333849007502 TilS substrate C-terminal domain; Region: TilS_C; smart00977 333849007503 hypothetical protein; Provisional; Region: PRK08582 333849007504 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 333849007505 RNA binding site [nucleotide binding]; other site 333849007506 Septum formation initiator; Region: DivIC; pfam04977 333849007507 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 333849007508 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 333849007509 RNA binding surface [nucleotide binding]; other site 333849007510 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 333849007511 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 333849007512 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 333849007513 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 333849007514 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 333849007515 ATP binding site [chemical binding]; other site 333849007516 putative Mg++ binding site [ion binding]; other site 333849007517 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 333849007518 nucleotide binding region [chemical binding]; other site 333849007519 ATP-binding site [chemical binding]; other site 333849007520 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 333849007521 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 333849007522 putative active site [active] 333849007523 catalytic residue [active] 333849007524 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 333849007525 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 333849007526 tetramer (dimer of dimers) interface [polypeptide binding]; other site 333849007527 NAD binding site [chemical binding]; other site 333849007528 dimer interface [polypeptide binding]; other site 333849007529 substrate binding site [chemical binding]; other site 333849007530 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 333849007531 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 333849007532 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 333849007533 hypothetical protein; Validated; Region: PRK00110 333849007534 Predicted integral membrane protein [Function unknown]; Region: COG5652 333849007535 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 333849007536 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_2; cd09607 333849007537 active site 333849007538 Zn binding site [ion binding]; other site 333849007539 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 333849007540 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 333849007541 NlpC/P60 family; Region: NLPC_P60; pfam00877 333849007542 rod shape-determining protein MreD; Region: MreD; pfam04093 333849007543 rod shape-determining protein MreC; Provisional; Region: PRK13922 333849007544 rod shape-determining protein MreC; Region: MreC; pfam04085 333849007545 Thiamine pyrophosphokinase; Region: TPK; cd07995 333849007546 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 333849007547 active site 333849007548 dimerization interface [polypeptide binding]; other site 333849007549 thiamine binding site [chemical binding]; other site 333849007550 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 333849007551 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 333849007552 substrate binding site [chemical binding]; other site 333849007553 hexamer interface [polypeptide binding]; other site 333849007554 metal binding site [ion binding]; metal-binding site 333849007555 GTPase RsgA; Reviewed; Region: PRK00098 333849007556 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 333849007557 RNA binding site [nucleotide binding]; other site 333849007558 homodimer interface [polypeptide binding]; other site 333849007559 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 333849007560 GTPase/Zn-binding domain interface [polypeptide binding]; other site 333849007561 GTP/Mg2+ binding site [chemical binding]; other site 333849007562 G4 box; other site 333849007563 G5 box; other site 333849007564 G1 box; other site 333849007565 Switch I region; other site 333849007566 G2 box; other site 333849007567 G3 box; other site 333849007568 Switch II region; other site 333849007569 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 333849007570 Catalytic domain of Protein Kinases; Region: PKc; cd00180 333849007571 active site 333849007572 ATP binding site [chemical binding]; other site 333849007573 substrate binding site [chemical binding]; other site 333849007574 activation loop (A-loop); other site 333849007575 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 333849007576 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 333849007577 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 333849007578 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 333849007579 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 333849007580 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 333849007581 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 333849007582 active site 333849007583 16S rRNA methyltransferase B; Provisional; Region: PRK14902 333849007584 NusB family; Region: NusB; pfam01029 333849007585 putative RNA binding site [nucleotide binding]; other site 333849007586 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 333849007587 S-adenosylmethionine binding site [chemical binding]; other site 333849007588 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 333849007589 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 333849007590 putative active site [active] 333849007591 substrate binding site [chemical binding]; other site 333849007592 putative cosubstrate binding site; other site 333849007593 catalytic site [active] 333849007594 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 333849007595 substrate binding site [chemical binding]; other site 333849007596 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 333849007597 active site 333849007598 catalytic residues [active] 333849007599 metal binding site [ion binding]; metal-binding site 333849007600 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 333849007601 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 333849007602 ATP binding site [chemical binding]; other site 333849007603 putative Mg++ binding site [ion binding]; other site 333849007604 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 333849007605 nucleotide binding region [chemical binding]; other site 333849007606 ATP-binding site [chemical binding]; other site 333849007607 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 333849007608 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 333849007609 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 333849007610 catalytic site [active] 333849007611 G-X2-G-X-G-K; other site 333849007612 hypothetical protein; Provisional; Region: PRK11820 333849007613 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 333849007614 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 333849007615 Uncharacterized protein conserved in bacteria (DUF2128); Region: DUF2128; pfam09901 333849007616 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 333849007617 active site 333849007618 nucleophile elbow; other site 333849007619 Thiamine transporter protein (Thia_YuaJ); Region: Thia_YuaJ; pfam09515 333849007620 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 333849007621 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 333849007622 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 333849007623 active site 333849007624 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 333849007625 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 333849007626 Substrate binding site; other site 333849007627 Mg++ binding site; other site 333849007628 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 333849007629 active site 333849007630 substrate binding site [chemical binding]; other site 333849007631 CoA binding site [chemical binding]; other site 333849007632 pur operon repressor; Provisional; Region: PRK09213 333849007633 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 333849007634 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 333849007635 active site 333849007636 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 333849007637 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 333849007638 ABC-ATPase subunit interface; other site 333849007639 dimer interface [polypeptide binding]; other site 333849007640 putative PBP binding regions; other site 333849007641 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 333849007642 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 333849007643 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 333849007644 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 333849007645 metal binding site [ion binding]; metal-binding site 333849007646 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 333849007647 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 333849007648 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 333849007649 Predicted integral membrane protein [Function unknown]; Region: COG0392 333849007650 Uncharacterized conserved protein [Function unknown]; Region: COG2898 333849007651 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 333849007652 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 333849007653 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 333849007654 Domain of unknown function (DUF3552); Region: DUF3552; pfam12072 333849007655 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 333849007656 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 333849007657 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 333849007658 Zn2+ binding site [ion binding]; other site 333849007659 Mg2+ binding site [ion binding]; other site 333849007660 recombinase A; Provisional; Region: recA; PRK09354 333849007661 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 333849007662 hexamer interface [polypeptide binding]; other site 333849007663 Walker A motif; other site 333849007664 ATP binding site [chemical binding]; other site 333849007665 Walker B motif; other site 333849007666 competence damage-inducible protein A; Provisional; Region: PRK00549 333849007667 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 333849007668 putative MPT binding site; other site 333849007669 Y-family of DNA polymerases; Region: PolY; cl12025 333849007670 Competence-damaged protein; Region: CinA; pfam02464 333849007671 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Region: pgsA; TIGR00560 333849007672 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 333849007673 Helix-turn-helix domain; Region: HTH_25; pfam13413 333849007674 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 333849007675 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 333849007676 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 333849007677 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 333849007678 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 333849007679 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 333849007680 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 333849007681 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 333849007682 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 333849007683 RNA polymerase factor sigma-70; Validated; Region: PRK08295 333849007684 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 333849007685 YacP-like NYN domain; Region: NYN_YacP; pfam05991 333849007686 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 333849007687 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 333849007688 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 333849007689 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 333849007690 active site 333849007691 metal binding site [ion binding]; metal-binding site 333849007692 dimerization interface [polypeptide binding]; other site 333849007693 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 333849007694 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 333849007695 active site 333849007696 HIGH motif; other site 333849007697 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 333849007698 KMSKS motif; other site 333849007699 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 333849007700 tRNA binding surface [nucleotide binding]; other site 333849007701 anticodon binding site; other site 333849007702 serine O-acetyltransferase; Region: cysE; TIGR01172 333849007703 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 333849007704 trimer interface [polypeptide binding]; other site 333849007705 active site 333849007706 substrate binding site [chemical binding]; other site 333849007707 CoA binding site [chemical binding]; other site 333849007708 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 333849007709 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 333849007710 HIGH motif; other site 333849007711 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 333849007712 active site 333849007713 KMSKS motif; other site 333849007714 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 333849007715 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 333849007716 putative active site [active] 333849007717 DNA repair protein RadA; Provisional; Region: PRK11823 333849007718 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 333849007719 Walker A motif/ATP binding site; other site 333849007720 ATP binding site [chemical binding]; other site 333849007721 Walker B motif; other site 333849007722 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 333849007723 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 333849007724 trimer interface [polypeptide binding]; other site 333849007725 active site 333849007726 Glutamate 5-kinase [Amino acid transport and metabolism]; Region: ProB; COG0263 333849007727 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 333849007728 nucleotide binding site [chemical binding]; other site 333849007729 homotetrameric interface [polypeptide binding]; other site 333849007730 putative phosphate binding site [ion binding]; other site 333849007731 putative allosteric binding site; other site 333849007732 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 333849007733 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 333849007734 putative catalytic cysteine [active] 333849007735 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 333849007736 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 333849007737 putative substrate translocation pore; other site 333849007738 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 333849007739 Predicted transcriptional regulators [Transcription]; Region: COG1695 333849007740 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 333849007741 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 333849007742 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 333849007743 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 333849007744 ABC transporter; Region: ABC_tran_2; pfam12848 333849007745 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 333849007746 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 333849007747 dimer interface [polypeptide binding]; other site 333849007748 FMN binding site [chemical binding]; other site 333849007749 Transcriptional regulators [Transcription]; Region: MarR; COG1846 333849007750 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 333849007751 putative DNA binding site [nucleotide binding]; other site 333849007752 putative Zn2+ binding site [ion binding]; other site 333849007753 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 333849007754 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 333849007755 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 333849007756 NAD(P) binding site [chemical binding]; other site 333849007757 active site 333849007758 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 333849007759 trimer interface [polypeptide binding]; other site 333849007760 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 333849007761 active site 333849007762 substrate binding site [chemical binding]; other site 333849007763 CoA binding site [chemical binding]; other site 333849007764 Transcriptional regulator [Transcription]; Region: LysR; COG0583 333849007765 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 333849007766 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 333849007767 dimerization interface [polypeptide binding]; other site 333849007768 transcriptional antiterminator BglG; Provisional; Region: PRK09772 333849007769 CAT RNA binding domain; Region: CAT_RBD; smart01061 333849007770 PRD domain; Region: PRD; pfam00874 333849007771 PRD domain; Region: PRD; pfam00874 333849007772 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 333849007773 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 333849007774 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 333849007775 active site turn [active] 333849007776 phosphorylation site [posttranslational modification] 333849007777 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 333849007778 HPr interaction site; other site 333849007779 glycerol kinase (GK) interaction site [polypeptide binding]; other site 333849007780 active site 333849007781 phosphorylation site [posttranslational modification] 333849007782 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 333849007783 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 333849007784 NADP binding site [chemical binding]; other site 333849007785 Predicted transcriptional regulator [Transcription]; Region: COG1959 333849007786 Transcriptional regulator; Region: Rrf2; pfam02082 333849007787 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 333849007788 Helix-turn-helix domain; Region: HTH_18; pfam12833 333849007789 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 333849007790 Uncharacterized conserved protein [Function unknown]; Region: COG4715 333849007791 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 333849007792 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 333849007793 Predicted membrane protein [Function unknown]; Region: COG4392 333849007794 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 333849007795 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 333849007796 putative NAD(P) binding site [chemical binding]; other site 333849007797 dimer interface [polypeptide binding]; other site 333849007798 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 333849007799 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 333849007800 FMN binding site [chemical binding]; other site 333849007801 active site 333849007802 catalytic residues [active] 333849007803 substrate binding site [chemical binding]; other site 333849007804 inner membrane transport permease; Provisional; Region: PRK15066 333849007805 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 333849007806 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 333849007807 Walker A/P-loop; other site 333849007808 ATP binding site [chemical binding]; other site 333849007809 Q-loop/lid; other site 333849007810 ABC transporter signature motif; other site 333849007811 Walker B; other site 333849007812 D-loop; other site 333849007813 H-loop/switch region; other site 333849007814 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 333849007815 Walker A/P-loop; other site 333849007816 ATP binding site [chemical binding]; other site 333849007817 Q-loop/lid; other site 333849007818 ABC transporter signature motif; other site 333849007819 Walker B; other site 333849007820 D-loop; other site 333849007821 H-loop/switch region; other site 333849007822 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 333849007823 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 333849007824 dimer interface [polypeptide binding]; other site 333849007825 phosphorylation site [posttranslational modification] 333849007826 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 333849007827 ATP binding site [chemical binding]; other site 333849007828 Mg2+ binding site [ion binding]; other site 333849007829 G-X-G motif; other site 333849007830 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 333849007831 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 333849007832 active site 333849007833 phosphorylation site [posttranslational modification] 333849007834 intermolecular recognition site; other site 333849007835 dimerization interface [polypeptide binding]; other site 333849007836 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 333849007837 DNA binding site [nucleotide binding] 333849007838 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 333849007839 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 333849007840 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 333849007841 Walker A/P-loop; other site 333849007842 ATP binding site [chemical binding]; other site 333849007843 Q-loop/lid; other site 333849007844 ABC transporter signature motif; other site 333849007845 Walker B; other site 333849007846 D-loop; other site 333849007847 H-loop/switch region; other site 333849007848 H+ Antiporter protein; Region: 2A0121; TIGR00900 333849007849 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 333849007850 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 333849007851 23S rRNA interface [nucleotide binding]; other site 333849007852 L3 interface [polypeptide binding]; other site 333849007853 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 333849007854 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 333849007855 dimerization interface [polypeptide binding]; other site 333849007856 DPS ferroxidase diiron center [ion binding]; other site 333849007857 ion pore; other site 333849007858 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 333849007859 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 333849007860 N- and C-terminal domain interface [polypeptide binding]; other site 333849007861 active site 333849007862 catalytic site [active] 333849007863 metal binding site [ion binding]; metal-binding site 333849007864 carbohydrate binding site [chemical binding]; other site 333849007865 ATP binding site [chemical binding]; other site 333849007866 hypothetical protein; Region: PHA00727 333849007867 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 333849007868 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 333849007869 methionine sulfoxide reductase A; Provisional; Region: PRK14054 333849007870 beta-phosphoglucomutase; Region: bPGM; TIGR01990 333849007871 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 333849007872 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 333849007873 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 333849007874 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 333849007875 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 333849007876 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 333849007877 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 333849007878 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 333849007879 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 333849007880 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 333849007881 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 333849007882 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 333849007883 putative NAD(P) binding site [chemical binding]; other site 333849007884 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 333849007885 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 333849007886 dimer interface [polypeptide binding]; other site 333849007887 conserved gate region; other site 333849007888 putative PBP binding loops; other site 333849007889 ABC-ATPase subunit interface; other site 333849007890 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 333849007891 dimer interface [polypeptide binding]; other site 333849007892 conserved gate region; other site 333849007893 putative PBP binding loops; other site 333849007894 ABC-ATPase subunit interface; other site 333849007895 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 333849007896 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 333849007897 Alpha amylase catalytic domain found in sucrose phosphorylase-like proteins (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase-like_1; cd11356 333849007898 sucrose phosphorylase; Region: sucrose_gtfA; TIGR03852 333849007899 active site 333849007900 homodimer interface [polypeptide binding]; other site 333849007901 catalytic site [active] 333849007902 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706 333849007903 Transcriptional regulators [Transcription]; Region: PurR; COG1609 333849007904 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 333849007905 DNA binding site [nucleotide binding] 333849007906 domain linker motif; other site 333849007907 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 333849007908 putative dimerization interface [polypeptide binding]; other site 333849007909 putative ligand binding site [chemical binding]; other site 333849007910 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 333849007911 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 333849007912 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 333849007913 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 333849007914 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 333849007915 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 333849007916 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 333849007917 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 333849007918 DNA binding site [nucleotide binding] 333849007919 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 333849007920 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 333849007921 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 333849007922 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 333849007923 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 333849007924 RPB1 interaction site [polypeptide binding]; other site 333849007925 RPB10 interaction site [polypeptide binding]; other site 333849007926 RPB11 interaction site [polypeptide binding]; other site 333849007927 RPB3 interaction site [polypeptide binding]; other site 333849007928 RPB12 interaction site [polypeptide binding]; other site 333849007929 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 333849007930 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 333849007931 zinc binding site [ion binding]; other site 333849007932 putative ligand binding site [chemical binding]; other site 333849007933 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 333849007934 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 333849007935 TM-ABC transporter signature motif; other site 333849007936 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 333849007937 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 333849007938 Walker A/P-loop; other site 333849007939 ATP binding site [chemical binding]; other site 333849007940 Q-loop/lid; other site 333849007941 ABC transporter signature motif; other site 333849007942 Walker B; other site 333849007943 D-loop; other site 333849007944 H-loop/switch region; other site 333849007945 Biotin operon repressor [Transcription]; Region: BirA; COG1654 333849007946 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 333849007947 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 333849007948 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 333849007949 DinB superfamily; Region: DinB_2; pfam12867 333849007950 choice-of-anchor A domain; Region: choice_anch_A; TIGR04215 333849007951 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 333849007952 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 333849007953 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 333849007954 substrate binding pocket [chemical binding]; other site 333849007955 chain length determination region; other site 333849007956 substrate-Mg2+ binding site; other site 333849007957 catalytic residues [active] 333849007958 aspartate-rich region 1; other site 333849007959 active site lid residues [active] 333849007960 aspartate-rich region 2; other site 333849007961 Heptaprenyl diphosphate synthase component I; Region: Hpre_diP_synt_I; pfam07456 333849007962 Listerrria innocua Lin0431 is similar to the N-Utilization Substance G (NusG) N terminal (NGN) insert (DII); Region: Lin0431_like; cd09911 333849007963 trimer interface [polypeptide binding]; other site 333849007964 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 333849007965 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 333849007966 This conserved region includes the FMN-binding site of the NqrC protein as well as the NosR and NirI regulatory proteins; Region: FMN_bind; smart00900 333849007967 FMN-binding domain; Region: FMN_bind; pfam04205 333849007968 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 333849007969 ApbE family; Region: ApbE; pfam02424 333849007970 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Provisional; Region: PRK13387 333849007971 UbiA prenyltransferase family; Region: UbiA; pfam01040 333849007972 glutathione reductase; Validated; Region: PRK06116 333849007973 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 333849007974 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 333849007975 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 333849007976 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 333849007977 Peptidase family U32; Region: Peptidase_U32; pfam01136 333849007978 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 333849007979 Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an important role in NAD production by either allowing quinolinic acid (QA) , quinolinate phosphoribosyl transferase (QAPRTase), or nicotinic acid (NA), nicotinate...; Region: PRTase_typeII; cl17275 333849007980 Peptidase family U32; Region: Peptidase_U32; pfam01136 333849007981 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 333849007982 Clp amino terminal domain; Region: Clp_N; pfam02861 333849007983 Clp amino terminal domain; Region: Clp_N; pfam02861 333849007984 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 333849007985 Walker A motif; other site 333849007986 ATP binding site [chemical binding]; other site 333849007987 Walker B motif; other site 333849007988 arginine finger; other site 333849007989 UvrB/uvrC motif; Region: UVR; pfam02151 333849007990 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 333849007991 Walker A motif; other site 333849007992 ATP binding site [chemical binding]; other site 333849007993 Walker B motif; other site 333849007994 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 333849007995 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848 333849007996 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 333849007997 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 333849007998 active site 333849007999 phosphorylation site [posttranslational modification] 333849008000 intermolecular recognition site; other site 333849008001 dimerization interface [polypeptide binding]; other site 333849008002 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 333849008003 DNA binding site [nucleotide binding] 333849008004 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 333849008005 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 333849008006 dimer interface [polypeptide binding]; other site 333849008007 phosphorylation site [posttranslational modification] 333849008008 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 333849008009 ATP binding site [chemical binding]; other site 333849008010 Mg2+ binding site [ion binding]; other site 333849008011 G-X-G motif; other site 333849008012 T-box leader; HMPREF0351_nc10032 333849008013 seryl-tRNA synthetase; Provisional; Region: PRK05431 333849008014 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 333849008015 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 333849008016 dimer interface [polypeptide binding]; other site 333849008017 active site 333849008018 motif 1; other site 333849008019 motif 2; other site 333849008020 motif 3; other site 333849008021 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 333849008022 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 333849008023 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 333849008024 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 333849008025 active site 333849008026 Protein of unknown function (DUF1129); Region: DUF1129; pfam06570 333849008027 GTP-binding protein YchF; Reviewed; Region: PRK09601 333849008028 YchF GTPase; Region: YchF; cd01900 333849008029 G1 box; other site 333849008030 GTP/Mg2+ binding site [chemical binding]; other site 333849008031 Switch I region; other site 333849008032 G2 box; other site 333849008033 Switch II region; other site 333849008034 G3 box; other site 333849008035 G4 box; other site 333849008036 G5 box; other site 333849008037 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 333849008038 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 333849008039 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 333849008040 ParB-like nuclease domain; Region: ParBc; pfam02195 333849008041 KorB domain; Region: KorB; pfam08535 333849008042 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 333849008043 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 333849008044 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 333849008045 Magnesium ion binding site [ion binding]; other site 333849008046 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 333849008047 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 333849008048 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 333849008049 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 333849008050 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 333849008051 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 333849008052 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 333849008053 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 333849008054 trmE is a tRNA modification GTPase; Region: trmE; cd04164 333849008055 G1 box; other site 333849008056 GTP/Mg2+ binding site [chemical binding]; other site 333849008057 Switch I region; other site 333849008058 G2 box; other site 333849008059 Switch II region; other site 333849008060 G3 box; other site 333849008061 G4 box; other site 333849008062 G5 box; other site 333849008063 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 333849008064 Putative heavy-metal-binding; Region: YbjQ_1; pfam01906 333849008065 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 333849008066 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 333849008067 G-X-X-G motif; other site 333849008068 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 333849008069 RxxxH motif; other site 333849008070 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 333849008071 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 333849008072 ribonuclease P; Reviewed; Region: rnpA; PRK00499 333849008073 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 333849008074 Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480 333849008075 Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168 333849008076 G1 box; other site 333849008077 putative GEF interaction site [polypeptide binding]; other site 333849008078 GTP/Mg2+ binding site [chemical binding]; other site 333849008079 Switch I region; other site 333849008080 G2 box; other site 333849008081 G3 box; other site 333849008082 Switch II region; other site 333849008083 G4 box; other site 333849008084 G5 box; other site 333849008085 Tet_II: This subfamily represents domain II of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to domain II of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome...; Region: Tet_II; cd03690 333849008086 EF-G_domain IV_RPP domain is a part of bacterial ribosomal protected proteins (RPP) family. RPPs such as tetracycline resistance proteins Tet(M) and Tet(O) mediate tetracycline resistance in both gram-positive and -negative species. Tetracyclines inhibit...; Region: Tet_like_IV; cd01684 333849008087 Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711 333849008088 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 333849008089 Major Facilitator Superfamily; Region: MFS_1; pfam07690 333849008090 putative substrate translocation pore; other site 333849008091 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 333849008092 Integrase core domain; Region: rve; pfam00665 333849008093 Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184 333849008094 Fic/DOC family; Region: Fic; cl00960 333849008095 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 333849008096 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 333849008097 catalytic residues [active] 333849008098 catalytic nucleophile [active] 333849008099 Presynaptic Site I dimer interface [polypeptide binding]; other site 333849008100 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 333849008101 Synaptic Flat tetramer interface [polypeptide binding]; other site 333849008102 Synaptic Site I dimer interface [polypeptide binding]; other site 333849008103 DNA binding site [nucleotide binding] 333849008104 Integrase core domain; Region: rve; pfam00665 333849008105 Integrase core domain; Region: rve_3; pfam13683 333849008106 potential frameshift: common BLAST hit: gi|346716404|ref|YP_004849411.1| transposase 333849008107 Integrase core domain; Region: rve_2; pfam13333 333849008108 potential frameshift: common BLAST hit: gi|346716404|ref|YP_004849411.1| transposase 333849008109 Integrase core domain; Region: rve; pfam00665 333849008110 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 333849008111 Transposase; Region: HTH_Tnp_1; pfam01527 333849008112 HTH-like domain; Region: HTH_21; pfam13276 333849008113 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 333849008114 Transposase; Region: HTH_Tnp_1; pfam01527 333849008115 AAA domain; Region: AAA_31; pfam13614 333849008116 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 333849008117 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 333849008118 Magnesium ion binding site [ion binding]; other site 333849008119 Primase C terminal 1 (PriCT-1); Region: PriCT_1; pfam08708 333849008120 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 333849008121 Helix-turn-helix domain; Region: HTH_38; pfam13936 333849008122 Integrase core domain; Region: rve; pfam00665 333849008123 Integrase core domain; Region: rve_3; cl15866 333849008124 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 333849008125 Integrase core domain; Region: rve; pfam00665 333849008126 Plasmid recombination enzyme; Region: Mob_Pre; pfam01076 333849008127 Plasmid rolling circle replication initiator protein and truncated derivatives [DNA replication, recombination, and repair]; Region: COG5655 333849008128 Replication protein; Region: Rep_1; cl02412 333849008129 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 333849008130 Integrase core domain; Region: rve; pfam00665 333849008131 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 333849008132 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 333849008133 catalytic residues [active] 333849008134 catalytic nucleophile [active] 333849008135 Presynaptic Site I dimer interface [polypeptide binding]; other site 333849008136 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 333849008137 Synaptic Flat tetramer interface [polypeptide binding]; other site 333849008138 Synaptic Site I dimer interface [polypeptide binding]; other site 333849008139 DNA binding site [nucleotide binding] 333849008140 Bacterial protein of unknown function (DUF961); Region: DUF961; pfam06125 333849008141 Bacterial protein of unknown function (DUF961); Region: DUF961; pfam06125 333849008142 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 333849008143 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 333849008144 Walker A motif; other site 333849008145 ATP binding site [chemical binding]; other site 333849008146 Walker B motif; other site 333849008147 arginine finger; other site 333849008148 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 333849008149 non-specific DNA binding site [nucleotide binding]; other site 333849008150 salt bridge; other site 333849008151 sequence-specific DNA binding site [nucleotide binding]; other site 333849008152 Replication initiation factor; Region: Rep_trans; pfam02486 333849008153 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 333849008154 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 333849008155 putative active site [active] 333849008156 putative NTP binding site [chemical binding]; other site 333849008157 putative nucleic acid binding site [nucleotide binding]; other site 333849008158 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 333849008159 active site 333849008160 Antirestriction protein (ArdA); Region: ArdA; pfam07275 333849008161 TcpE family; Region: TcpE; pfam12648 333849008162 AAA-like domain; Region: AAA_10; pfam12846 333849008163 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 333849008164 Haemolysin-III related; Region: HlyIII; cl03831 333849008165 MAP7 (E-MAP-115) family; Region: MAP7; pfam05672 333849008166 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 333849008167 N-acetyl-D-glucosamine binding site [chemical binding]; other site 333849008168 catalytic residue [active] 333849008169 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 333849008170 NlpC/P60 family; Region: NLPC_P60; pfam00877 333849008171 Conjugative transposon protein TcpC; Region: TpcC; pfam12642 333849008172 Streptomycin adenylyltransferase; Region: Adenyl_transf; pfam04439 333849008173 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 333849008174 Integrase core domain; Region: rve; pfam00665 333849008175 HTH domain; Region: HTH_11; cl17392 333849008176 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 333849008177 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 333849008178 non-specific DNA binding site [nucleotide binding]; other site 333849008179 salt bridge; other site 333849008180 sequence-specific DNA binding site [nucleotide binding]; other site 333849008181 Bacteriocin (Lactococcin_972); Region: Lactococcin_972; cl09891 333849008182 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4652 333849008183 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 333849008184 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 333849008185 Walker A/P-loop; other site 333849008186 ATP binding site [chemical binding]; other site 333849008187 Q-loop/lid; other site 333849008188 ABC transporter signature motif; other site 333849008189 Walker B; other site 333849008190 D-loop; other site 333849008191 H-loop/switch region; other site 333849008192 Bacterial mobilisation protein (MobC); Region: MobC; pfam05713 333849008193 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 333849008194 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 333849008195 Integrase core domain; Region: rve; pfam00665 333849008196 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 333849008197 Transposase; Region: HTH_Tnp_1; pfam01527 333849008198 Primase C terminal 1 (PriCT-1); Region: PriCT_1; pfam08708 333849008199 Transcriptional regulator; Region: Rrf2; cl17282 333849008200 Transposase; Region: DEDD_Tnp_IS110; pfam01548 333849008201 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 333849008202 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 333849008203 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 333849008204 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 333849008205 P-loop; other site 333849008206 Magnesium ion binding site [ion binding]; other site 333849008207 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 333849008208 Magnesium ion binding site [ion binding]; other site 333849008209 Transposase, Mutator family; Region: Transposase_mut; pfam00872 333849008210 MULE transposase domain; Region: MULE; pfam10551 333849008211 DNA polymerase IV; Reviewed; Region: PRK03103 333849008212 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 333849008213 active site 333849008214 DNA binding site [nucleotide binding] 333849008215 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 333849008216 Transposase domain (DUF772); Region: DUF772; pfam05598 333849008217 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 333849008218 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 333849008219 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 333849008220 multiple promoter invertase; Provisional; Region: mpi; PRK13413 333849008221 catalytic residues [active] 333849008222 catalytic nucleophile [active] 333849008223 Presynaptic Site I dimer interface [polypeptide binding]; other site 333849008224 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 333849008225 Synaptic Flat tetramer interface [polypeptide binding]; other site 333849008226 Synaptic Site I dimer interface [polypeptide binding]; other site 333849008227 DNA binding site [nucleotide binding] 333849008228 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 333849008229 DNA-binding interface [nucleotide binding]; DNA binding site 333849008230 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 333849008231 Helix-turn-helix domain; Region: HTH_38; pfam13936 333849008232 Integrase core domain; Region: rve; pfam00665 333849008233 Prophage maintenance system killer protein [General function prediction only]; Region: Doc; COG3654 333849008234 putative addiction module antidote; Region: doc_partner; TIGR02609 333849008235 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 333849008236 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 333849008237 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 333849008238 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 333849008239 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 333849008240 A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710 333849008241 putative active site [active] 333849008242 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 333849008243 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 333849008244 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 333849008245 DNA-binding site [nucleotide binding]; DNA binding site 333849008246 UTRA domain; Region: UTRA; pfam07702 333849008247 Fructoselysine kinase-like. Fructoselysine is a fructoseamine formed by glycation, a non-enzymatic reaction of glucose with a primary amine followed by an Amadori rearrangement, resulting in a protein that is modified at the amino terminus and at the...; Region: Fructoselysine_kinase_like; cd01940 333849008248 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 333849008249 substrate binding site [chemical binding]; other site 333849008250 ATP binding site [chemical binding]; other site 333849008251 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 333849008252 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 333849008253 DNA-binding site [nucleotide binding]; DNA binding site 333849008254 UTRA domain; Region: UTRA; pfam07702 333849008255 putative fructoselysine transporter; Provisional; Region: frlA; PRK11357 333849008256 hypothetical protein; Provisional; Region: PHA02764 333849008257 Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894 333849008258 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 333849008259 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 333849008260 Amidohydrolase; Region: Amidohydro_5; pfam13594 333849008261 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 333849008262 active site 333849008263 Transposase, Mutator family; Region: Transposase_mut; pfam00872 333849008264 MULE transposase domain; Region: MULE; pfam10551 333849008265 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 333849008266 Integrase core domain; Region: rve; pfam00665 333849008267 WYL domain; Region: WYL; pfam13280 333849008268 Predicted transcriptional regulator [Transcription]; Region: COG2378 333849008269 HTH domain; Region: HTH_11; pfam08279 333849008270 WYL domain; Region: WYL; pfam13280 333849008271 Aminoglycoside 3'-phosphotransferase (APH). The APH subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin...; Region: APH; cd05150 333849008272 active site 333849008273 ATP binding site [chemical binding]; other site 333849008274 Phosphotransferase enzyme family; Region: APH; pfam01636 333849008275 antibiotic binding site [chemical binding]; other site 333849008276 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 333849008277 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 333849008278 Coenzyme A binding pocket [chemical binding]; other site 333849008279 Streptomycin adenylyltransferase; Region: Adenyl_transf; pfam04439 333849008280 Methyltransferase domain; Region: Methyltransf_31; pfam13847 333849008281 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 333849008282 S-adenosylmethionine binding site [chemical binding]; other site 333849008283 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 333849008284 active site 333849008285 NTP binding site [chemical binding]; other site 333849008286 metal binding triad [ion binding]; metal-binding site 333849008287 Domain of unknown function (DUF1413); Region: DUF1413; pfam07205 333849008288 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 333849008289 Ribosomal RNA adenine dimethylase; Region: RrnaAD; pfam00398 333849008290 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 333849008291 S-adenosylmethionine binding site [chemical binding]; other site 333849008292 Omega Transcriptional Repressor; Region: Omega_Repress; pfam07764 333849008293 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 333849008294 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 333849008295 Integrase core domain; Region: rve; pfam00665 333849008296 Replication initiation factor; Region: Rep_trans; pfam02486 333849008297 Transposase, Mutator family; Region: Transposase_mut; pfam00872 333849008298 MULE transposase domain; Region: MULE; pfam10551 333849008299 Chloramphenicol acetyltransferase; Region: CAT; cl02008 333849008300 Chloramphenicol O-acetyltransferase [Defense mechanisms]; Region: COG4845 333849008301 T-DNA border endonuclease VirD1; Region: VirD1; cl17530 333849008302 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 333849008303 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 333849008304 Integrase core domain; Region: rve; pfam00665 333849008305 Replication initiator protein A (RepA) N-terminus; Region: RepA_N; pfam06970 333849008306 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 333849008307 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 333849008308 P-loop; other site 333849008309 Magnesium ion binding site [ion binding]; other site 333849008310 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 333849008311 Magnesium ion binding site [ion binding]; other site 333849008312 DNA polymerase IV; Reviewed; Region: PRK03103 333849008313 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 333849008314 active site 333849008315 DNA binding site [nucleotide binding] 333849008316 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 333849008317 multiple promoter invertase; Provisional; Region: mpi; PRK13413 333849008318 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 333849008319 catalytic residues [active] 333849008320 catalytic nucleophile [active] 333849008321 Presynaptic Site I dimer interface [polypeptide binding]; other site 333849008322 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 333849008323 Synaptic Flat tetramer interface [polypeptide binding]; other site 333849008324 Synaptic Site I dimer interface [polypeptide binding]; other site 333849008325 DNA binding site [nucleotide binding] 333849008326 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 333849008327 DNA-binding interface [nucleotide binding]; DNA binding site 333849008328 toxin-antitoxin system, toxin component, Txe/YoeB family; Region: toxin_Txe_YoeB; TIGR02116 333849008329 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 333849008330 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 333849008331 Integrase core domain; Region: rve; pfam00665 333849008332 HTH domain; Region: HTH_11; pfam08279 333849008333 Aminoglycoside 3'-phosphotransferase (APH). The APH subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin...; Region: APH; cd05150 333849008334 active site 333849008335 ATP binding site [chemical binding]; other site 333849008336 Phosphotransferase enzyme family; Region: APH; pfam01636 333849008337 antibiotic binding site [chemical binding]; other site 333849008338 Protein of unknown function (DUF3991); Region: DUF3991; pfam13154 333849008339 Toprim-like; Region: Toprim_2; pfam13155 333849008340 ATP synthase CF1 alpha subunit; Region: atpA; CHL00059 333849008341 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 333849008342 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 333849008343 Peptidase family M23; Region: Peptidase_M23; pfam01551 333849008344 AAA-like domain; Region: AAA_10; pfam12846 333849008345 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 333849008346 Walker A motif; other site 333849008347 ATP binding site [chemical binding]; other site 333849008348 Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505 333849008349 TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696 333849008350 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 333849008351 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 333849008352 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 333849008353 active site 333849008354 catalytic site [active] 333849008355 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 333849008356 Cna protein B-type domain; Region: Cna_B; pfam05738 333849008357 Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165 333849008358 active site 333849008359 catalytic site [active] 333849008360 Replication initiator protein A (RepA) N-terminus; Region: RepA_N; pfam06970 333849008361 Transposase, Mutator family; Region: Transposase_mut; pfam00872 333849008362 MULE transposase domain; Region: MULE; pfam10551 333849008363 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 333849008364 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 333849008365 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 333849008366 Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389 333849008367 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 333849008368 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 333849008369 Integrase core domain; Region: rve; pfam00665 333849008370 transposase/IS protein; Provisional; Region: PRK09183 333849008371 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 333849008372 Walker A motif; other site 333849008373 ATP binding site [chemical binding]; other site 333849008374 Walker B motif; other site 333849008375 arginine finger; other site 333849008376 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 333849008377 Integrase core domain; Region: rve; pfam00665 333849008378 Metal-dependent hydrolases of the beta-lactamase superfamily II [General function prediction only]; Region: COG1237 333849008379 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 333849008380 active pocket/dimerization site; other site 333849008381 active site 333849008382 phosphorylation site [posttranslational modification] 333849008383 PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830 333849008384 active site 333849008385 phosphorylation site [posttranslational modification] 333849008386 PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609 333849008387 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 333849008388 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 333849008389 A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710 333849008390 putative active site [active] 333849008391 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 333849008392 dimer interface [polypeptide binding]; other site 333849008393 active site 333849008394 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 333849008395 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 333849008396 Walker A motif; other site 333849008397 ATP binding site [chemical binding]; other site 333849008398 Walker B motif; other site 333849008399 arginine finger; other site 333849008400 Transcriptional antiterminator [Transcription]; Region: COG3933 333849008401 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 333849008402 active pocket/dimerization site; other site 333849008403 active site 333849008404 phosphorylation site [posttranslational modification] 333849008405 PRD domain; Region: PRD; pfam00874 333849008406 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 333849008407 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 333849008408 active site 333849008409 motif I; other site 333849008410 motif II; other site 333849008411 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 333849008412 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 333849008413 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 333849008414 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 333849008415 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 333849008416 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 333849008417 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 333849008418 Mga helix-turn-helix domain; Region: Mga; pfam05043 333849008419 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 333849008420 Integrase core domain; Region: rve; pfam00665 333849008421 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 333849008422 Transposase; Region: DDE_Tnp_ISL3; pfam01610 333849008423 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 333849008424 Transposase; Region: DDE_Tnp_ISL3; pfam01610 333849008425 Type I restriction and modification enzyme - subunit R C terminal; Region: EcoR124_C; pfam12008 333849008426 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 333849008427 A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710 333849008428 putative active site [active] 333849008429 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 333849008430 dimer interface [polypeptide binding]; other site 333849008431 active site 333849008432 Fructoselysine kinase-like. Fructoselysine is a fructoseamine formed by glycation, a non-enzymatic reaction of glucose with a primary amine followed by an Amadori rearrangement, resulting in a protein that is modified at the amino terminus and at the...; Region: Fructoselysine_kinase_like; cd01940 333849008433 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 333849008434 substrate binding site [chemical binding]; other site 333849008435 ATP binding site [chemical binding]; other site 333849008436 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 333849008437 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 333849008438 DNA-binding site [nucleotide binding]; DNA binding site 333849008439 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 333849008440 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 333849008441 active site 333849008442 potential frameshift: common BLAST hit: gi|383329997|ref|YP_005355881.1| IS16/IS256, transposase 333849008443 MULE transposase domain; Region: MULE; pfam10551 333849008444 Transposase, Mutator family; Region: Transposase_mut; pfam00872 333849008445 Predicted membrane protein [Function unknown]; Region: COG1288 333849008446 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 333849008447 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 333849008448 DDE domain; Region: DDE_Tnp_IS240; pfam13610 333849008449 Integrase core domain; Region: rve; pfam00665 333849008450 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 333849008451 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 333849008452 P-loop; other site 333849008453 Magnesium ion binding site [ion binding]; other site 333849008454 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 333849008455 Magnesium ion binding site [ion binding]; other site 333849008456 potential frameshift: common BLAST hit: gi|352518545|ref|YP_004887862.1| putative transposase for insertion sequence element 333849008457 DDE domain; Region: DDE_Tnp_IS240; pfam13610 333849008458 Integrase core domain; Region: rve; pfam00665 333849008459 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 333849008460 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 333849008461 DNA-binding site [nucleotide binding]; DNA binding site 333849008462 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 333849008463 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 333849008464 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 333849008465 DNA-binding site [nucleotide binding]; DNA binding site 333849008466 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 333849008467 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 333849008468 A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710 333849008469 putative active site [active] 333849008470 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 333849008471 dimer interface [polypeptide binding]; other site 333849008472 active site 333849008473 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 333849008474 active pocket/dimerization site; other site 333849008475 active site 333849008476 phosphorylation site [posttranslational modification] 333849008477 PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830 333849008478 active site 333849008479 phosphorylation site [posttranslational modification] 333849008480 PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609 333849008481 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 333849008482 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 333849008483 Integrase core domain; Region: rve; pfam00665 333849008484 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 333849008485 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 333849008486 active site turn [active] 333849008487 phosphorylation site [posttranslational modification] 333849008488 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 333849008489 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 333849008490 HPr interaction site; other site 333849008491 glycerol kinase (GK) interaction site [polypeptide binding]; other site 333849008492 active site 333849008493 phosphorylation site [posttranslational modification] 333849008494 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 333849008495 beta-galactosidase; Region: BGL; TIGR03356 333849008496 transcriptional antiterminator BglG; Provisional; Region: PRK09772 333849008497 CAT RNA binding domain; Region: CAT_RBD; smart01061 333849008498 PRD domain; Region: PRD; pfam00874 333849008499 PRD domain; Region: PRD; pfam00874 333849008500 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 333849008501 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 333849008502 Homeodomain-like domain; Region: HTH_23; pfam13384 333849008503 Transposase; Region: DDE_Tnp_ISL3; pfam01610 333849008504 potential frameshift: common BLAST hit: gi|352518208|ref|YP_004887525.1| beta-glucoside-specific phosphotransferase system enzyme II 333849008505 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 333849008506 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 333849008507 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 333849008508 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 333849008509 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 333849008510 Helix-turn-helix domain; Region: HTH_38; pfam13936 333849008511 Integrase core domain; Region: rve; pfam00665 333849008512 potential frameshift: common BLAST hit: gi|383327640|ref|YP_005353524.1| putative cell surface protein 333849008513 6-pyruvoyl-tetrahydropterin synthase related domain; membrane protein; Region: PTPS_related; pfam10131 333849008514 putative transposase OrfB; Reviewed; Region: PHA02517 333849008515 HTH-like domain; Region: HTH_21; pfam13276 333849008516 Integrase core domain; Region: rve; pfam00665 333849008517 Integrase core domain; Region: rve_2; pfam13333 333849008518 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 333849008519 Transposase; Region: HTH_Tnp_1; pfam01527 333849008520 Protein of unknown function (DUF1706); Region: DUF1706; pfam08020 333849008521 Transposase, Mutator family; Region: Transposase_mut; pfam00872 333849008522 MULE transposase domain; Region: MULE; pfam10551 333849008523 Uncharacterized conserved protein [Function unknown]; Region: COG5495 333849008524 Rossmann-like domain; Region: Rossmann-like; pfam10727 333849008525 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 333849008526 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 333849008527 active site 333849008528 oligomerization interface [polypeptide binding]; other site 333849008529 metal binding site [ion binding]; metal-binding site 333849008530 Pantoate-beta-alanine ligase; Region: PanC; cd00560 333849008531 pantoate--beta-alanine ligase; Region: panC; TIGR00018 333849008532 active site 333849008533 ATP-binding site [chemical binding]; other site 333849008534 pantoate-binding site; other site 333849008535 HXXH motif; other site 333849008536 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 333849008537 tetramerization interface [polypeptide binding]; other site 333849008538 active site 333849008539 Transposase; Region: HTH_Tnp_1; pfam01527 333849008540 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 333849008541 putative transposase OrfB; Reviewed; Region: PHA02517 333849008542 Integrase core domain; Region: rve; pfam00665 333849008543 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4652 333849008544 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 333849008545 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 333849008546 Walker A/P-loop; other site 333849008547 ATP binding site [chemical binding]; other site 333849008548 Q-loop/lid; other site 333849008549 ABC transporter signature motif; other site 333849008550 Walker B; other site 333849008551 D-loop; other site 333849008552 H-loop/switch region; other site 333849008553 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 333849008554 Transposase; Region: DDE_Tnp_ISL3; pfam01610 333849008555 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 333849008556 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 333849008557 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 333849008558 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 333849008559 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 333849008560 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 333849008561 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 333849008562 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 333849008563 Transposase; Region: DDE_Tnp_ISL3; pfam01610 333849008564 Transposase, Mutator family; Region: Transposase_mut; pfam00872 333849008565 MULE transposase domain; Region: MULE; pfam10551 333849008566 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 333849008567 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 333849008568 DNA-binding site [nucleotide binding]; DNA binding site 333849008569 UTRA domain; Region: UTRA; pfam07702 333849008570 putative sugar isomerase, AgaS family; Region: agaS_fam; TIGR02815 333849008571 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 333849008572 dimer interface [polypeptide binding]; other site 333849008573 active site 333849008574 AgaS-like protein. AgaS contains a SIS (Sugar ISomerase) domain which is found in many phosphosugar isomerases and phosphosugar binding proteins. AgaS is a putative isomerase in Escherichia coli. It is similar to the glucosamine-6-phosphate synthases; Region: SIS_AgaS_like; cd05010 333849008575 putative active site [active] 333849008576 Class I aldolases; Region: Aldolase_Class_I; cl17187 333849008577 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 333849008578 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 333849008579 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 333849008580 Helix-turn-helix domain; Region: HTH_38; pfam13936 333849008581 Homeodomain-like domain; Region: HTH_32; pfam13565 333849008582 Integrase core domain; Region: rve; pfam00665 333849008583 Integrase core domain; Region: rve_3; cl15866 333849008584 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 333849008585 Transposase; Region: DDE_Tnp_ISL3; pfam01610 333849008586 potential frameshift: common BLAST hit: gi|383328722|ref|YP_005354606.1| IS1251-like transposase 333849008587 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 333849008588 Transposase; Region: DDE_Tnp_ISL3; pfam01610 333849008589 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 333849008590 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 333849008591 Homeodomain-like domain; Region: HTH_23; pfam13384 333849008592 Transposase; Region: DDE_Tnp_ISL3; pfam01610 333849008593 site-specific tyrosine recombinase XerS; Reviewed; Region: xerS; PRK05084 333849008594 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 333849008595 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 333849008596 active site 333849008597 DNA binding site [nucleotide binding] 333849008598 Int/Topo IB signature motif; other site 333849008599 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 333849008600 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 333849008601 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 333849008602 Sulfatase; Region: Sulfatase; cl17466 333849008603 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 333849008604 PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609 333849008605 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 333849008606 active pocket/dimerization site; other site 333849008607 active site 333849008608 phosphorylation site [posttranslational modification] 333849008609 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 333849008610 active site 333849008611 phosphorylation site [posttranslational modification] 333849008612 Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301 333849008613 UTRA domain; Region: UTRA; cl17743 333849008614 anaerobic sulfatase-maturase; Provisional; Region: PRK13758 333849008615 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 333849008616 FeS/SAM binding site; other site 333849008617 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 333849008618 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 333849008619 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 333849008620 Transposase; Region: DDE_Tnp_ISL3; pfam01610 333849008621 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 333849008622 Transposase; Region: DDE_Tnp_ISL3; pfam01610 333849008623 potential frameshift: common BLAST hit: gi|383329303|ref|YP_005355187.1| Transposase IS66 family 333849008624 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 333849008625 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 333849008626 potential frameshift: common BLAST hit: gi|383329303|ref|YP_005355187.1| Transposase IS66 family 333849008627 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 333849008628 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 333849008629 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 333849008630 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 333849008631 Transposase, Mutator family; Region: Transposase_mut; pfam00872 333849008632 MULE transposase domain; Region: MULE; pfam10551 333849008633 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 333849008634 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 333849008635 dimer interface [polypeptide binding]; other site 333849008636 phosphorylation site [posttranslational modification] 333849008637 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 333849008638 ATP binding site [chemical binding]; other site 333849008639 Mg2+ binding site [ion binding]; other site 333849008640 G-X-G motif; other site 333849008641 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 333849008642 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 333849008643 active site 333849008644 phosphorylation site [posttranslational modification] 333849008645 intermolecular recognition site; other site 333849008646 dimerization interface [polypeptide binding]; other site 333849008647 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 333849008648 DNA binding site [nucleotide binding] 333849008649 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 333849008650 Transposase; Region: DDE_Tnp_ISL3; pfam01610 333849008651 GMP synthase; Reviewed; Region: guaA; PRK00074 333849008652 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 333849008653 AMP/PPi binding site [chemical binding]; other site 333849008654 candidate oxyanion hole; other site 333849008655 catalytic triad [active] 333849008656 potential glutamine specificity residues [chemical binding]; other site 333849008657 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 333849008658 ATP Binding subdomain [chemical binding]; other site 333849008659 Dimerization subdomain; other site 333849008660 beta-N-acetylglucosaminidase; Region: NAGidase; pfam07555 333849008661 cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340 333849008662 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 333849008663 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 333849008664 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 333849008665 Beta galactosidase small chain; Region: Bgal_small_N; smart01038 333849008666 Glycosyl hydrolase family 20 (GH20) catalytic domain of N-acetyl-beta-D-glucosaminidase (GcnA, also known as BhsA) and related proteins. GcnA is an exoglucosidase which cleaves N-acetyl-beta-D-galactosamine (NAG) and N-acetyl-beta-D-galactosamine...; Region: GH20_GcnA-like; cd06565 333849008667 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 333849008668 putative active site [active] 333849008669 Protein of unknown function, DUF624; Region: DUF624; cl02369 333849008670 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 333849008671 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 333849008672 Domain of unknown function (DUF3502); Region: DUF3502; pfam12010 333849008673 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 333849008674 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 333849008675 dimer interface [polypeptide binding]; other site 333849008676 conserved gate region; other site 333849008677 putative PBP binding loops; other site 333849008678 ABC-ATPase subunit interface; other site 333849008679 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 333849008680 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 333849008681 dimer interface [polypeptide binding]; other site 333849008682 conserved gate region; other site 333849008683 ABC-ATPase subunit interface; other site 333849008684 Histidine kinase; Region: His_kinase; pfam06580 333849008685 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 333849008686 ATP binding site [chemical binding]; other site 333849008687 Mg2+ binding site [ion binding]; other site 333849008688 G-X-G motif; other site 333849008689 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 333849008690 active site 333849008691 phosphorylation site [posttranslational modification] 333849008692 intermolecular recognition site; other site 333849008693 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 333849008694 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 333849008695 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 333849008696 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 333849008697 Transposase; Region: DDE_Tnp_ISL3; pfam01610 333849008698 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 333849008699 Transposase; Region: DDE_Tnp_ISL3; pfam01610 333849008700 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 333849008701 Transposase; Region: DDE_Tnp_ISL3; pfam01610 333849008702 PemK-like protein; Region: PemK; cl00995 333849008703 RelB antitoxin; Region: RelB; cl01171 333849008704 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 333849008705 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 333849008706 active site 333849008707 metal binding site [ion binding]; metal-binding site 333849008708 hexamer interface [polypeptide binding]; other site 333849008709 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 333849008710 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 333849008711 Walker A/P-loop; other site 333849008712 ATP binding site [chemical binding]; other site 333849008713 Q-loop/lid; other site 333849008714 ABC transporter signature motif; other site 333849008715 Walker B; other site 333849008716 D-loop; other site 333849008717 H-loop/switch region; other site 333849008718 TOBE domain; Region: TOBE_2; pfam08402 333849008719 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 333849008720 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 333849008721 dimer interface [polypeptide binding]; other site 333849008722 conserved gate region; other site 333849008723 putative PBP binding loops; other site 333849008724 ABC-ATPase subunit interface; other site 333849008725 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 333849008726 dimer interface [polypeptide binding]; other site 333849008727 conserved gate region; other site 333849008728 putative PBP binding loops; other site 333849008729 ABC-ATPase subunit interface; other site 333849008730 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 333849008731 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 333849008732 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 333849008733 active site 333849008734 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 333849008735 catalytic site [active] 333849008736 active site 333849008737 potential frameshift: common BLAST hit: gi|383330022|ref|YP_005355906.1| ISEfa7, transposase 333849008738 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 333849008739 potential frameshift: common BLAST hit: gi|383327899|ref|YP_005353783.1| ISEfa7, transposase 333849008740 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 333849008741 Transposase domain (DUF772); Region: DUF772; pfam05598 333849008742 Transposase, Mutator family; Region: Transposase_mut; pfam00872 333849008743 MULE transposase domain; Region: MULE; pfam10551 333849008744 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 333849008745 FtsX-like permease family; Region: FtsX; pfam02687 333849008746 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 333849008747 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 333849008748 Walker A/P-loop; other site 333849008749 ATP binding site [chemical binding]; other site 333849008750 Q-loop/lid; other site 333849008751 ABC transporter signature motif; other site 333849008752 Walker B; other site 333849008753 D-loop; other site 333849008754 H-loop/switch region; other site 333849008755 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 333849008756 Transposase; Region: HTH_Tnp_1; pfam01527 333849008757 putative transposase OrfB; Reviewed; Region: PHA02517 333849008758 Integrase core domain; Region: rve; pfam00665 333849008759 Integrase core domain; Region: rve_3; pfam13683 333849008760 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 333849008761 catalytic residues [active] 333849008762 potential frameshift: common BLAST hit: gi|383328729|ref|YP_005354613.1| ISEfa8, transposase 333849008763 Transposase; Region: HTH_Tnp_1; cl17663 333849008764 putative transposase OrfB; Reviewed; Region: PHA02517 333849008765 Integrase core domain; Region: rve; pfam00665 333849008766 Integrase core domain; Region: rve_3; pfam13683 333849008767 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 333849008768 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 333849008769 Helix-turn-helix domain; Region: HTH_38; pfam13936 333849008770 Homeodomain-like domain; Region: HTH_32; pfam13565 333849008771 Integrase core domain; Region: rve; pfam00665 333849008772 Integrase core domain; Region: rve_3; cl15866 333849008773 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 333849008774 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 333849008775 INT_SG3, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 3, catalytic domain. The CD contains various predicted bacterial and phage integrase/recombinase sequences for which not much experimental characterization is available; Region: INT_SG3_C; cd01186 333849008776 Int/Topo IB signature motif; other site 333849008777 Transposase domain (DUF772); Region: DUF772; pfam05598 333849008778 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 333849008779 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 333849008780 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 333849008781 Transposase; Region: HTH_Tnp_1; pfam01527 333849008782 putative transposase OrfB; Reviewed; Region: PHA02517 333849008783 HTH-like domain; Region: HTH_21; pfam13276 333849008784 Integrase core domain; Region: rve; pfam00665 333849008785 Integrase core domain; Region: rve_2; pfam13333 333849008786 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 333849008787 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 333849008788 Homeodomain-like domain; Region: HTH_23; pfam13384 333849008789 Transposase; Region: DDE_Tnp_ISL3; pfam01610 333849008790 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 333849008791 HPr interaction site; other site 333849008792 glycerol kinase (GK) interaction site [polypeptide binding]; other site 333849008793 active site 333849008794 phosphorylation site [posttranslational modification] 333849008795 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 333849008796 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 333849008797 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 333849008798 active site turn [active] 333849008799 phosphorylation site [posttranslational modification] 333849008800 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 333849008801 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 333849008802 putative active site cavity [active] 333849008803 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 333849008804 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 333849008805 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 333849008806 putative active site [active] 333849008807 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 333849008808 Transposase; Region: DDE_Tnp_ISL3; pfam01610 333849008809 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 333849008810 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 333849008811 nucleotide binding site [chemical binding]; other site 333849008812 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 333849008813 Helix-turn-helix domain; Region: HTH_38; pfam13936 333849008814 Integrase core domain; Region: rve; pfam00665 333849008815 Protein of unknown function (DUF1237); Region: DUF1237; pfam06824 333849008816 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 333849008817 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 333849008818 Coenzyme A binding pocket [chemical binding]; other site 333849008819 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 333849008820 Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH6; cd08194 333849008821 putative active site [active] 333849008822 metal binding site [ion binding]; metal-binding site 333849008823 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 333849008824 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 333849008825 PYR/PP interface [polypeptide binding]; other site 333849008826 dimer interface [polypeptide binding]; other site 333849008827 TPP binding site [chemical binding]; other site 333849008828 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 333849008829 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 333849008830 TPP-binding site [chemical binding]; other site 333849008831 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 333849008832 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 333849008833 substrate binding site [chemical binding]; other site 333849008834 ATP binding site [chemical binding]; other site 333849008835 KduI/IolB family; Region: KduI; pfam04962 333849008836 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 333849008837 trimer interface [polypeptide binding]; other site 333849008838 active site 333849008839 G bulge; other site 333849008840 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 333849008841 N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789 333849008842 active site 333849008843 catalytic site [active] 333849008844 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; pfam09261 333849008845 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 333849008846 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 333849008847 Integrase core domain; Region: rve; pfam00665 333849008848 Uncharacterized conserved protein [Function unknown]; Region: COG1284 333849008849 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 333849008850 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 333849008851 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 333849008852 active site 333849008853 P-loop; other site 333849008854 phosphorylation site [posttranslational modification] 333849008855 methionine cluster; other site 333849008856 PTS system, Lactose/Cellobiose specific IIA subunit; Region: PTS_IIA; pfam02255 333849008857 active site 333849008858 phosphorylation site [posttranslational modification] 333849008859 metal binding site [ion binding]; metal-binding site 333849008860 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 333849008861 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 333849008862 active site 333849008863 P-loop; other site 333849008864 phosphorylation site [posttranslational modification] 333849008865 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 333849008866 active site 333849008867 phosphorylation site [posttranslational modification] 333849008868 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 333849008869 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 333849008870 dimer interface [polypeptide binding]; other site 333849008871 conserved gate region; other site 333849008872 putative PBP binding loops; other site 333849008873 ABC-ATPase subunit interface; other site 333849008874 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 333849008875 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 333849008876 dimer interface [polypeptide binding]; other site 333849008877 conserved gate region; other site 333849008878 putative PBP binding loops; other site 333849008879 ABC-ATPase subunit interface; other site 333849008880 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 333849008881 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 333849008882 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 333849008883 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 333849008884 active site 333849008885 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 333849008886 catalytic tetrad [active] 333849008887 Saccharomyces cerevisiae DCR2 phosphatase and related proteins, metallophosphatase domain; Region: MPP_Dcr2; cd07383 333849008888 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 333849008889 putative active site [active] 333849008890 putative metal binding site [ion binding]; other site 333849008891 Saccharomyces cerevisiae DCR2 phosphatase and related proteins, metallophosphatase domain; Region: MPP_Dcr2; cd07383 333849008892 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 333849008893 PcfJ-like protein; Region: PcfJ; pfam14284 333849008894 PcfK-like protein; Region: PcfK; pfam14058 333849008895 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 333849008896 potential frameshift: common BLAST hit: gi|352518545|ref|YP_004887862.1| putative transposase for insertion sequence element 333849008897 DDE domain; Region: DDE_Tnp_IS240; pfam13610 333849008898 Integrase core domain; Region: rve; pfam00665 333849008899 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 333849008900 potential frameshift: common BLAST hit: gi|29376763|ref|NP_815917.1| phosphosugar-binding transcriptional regulator 333849008901 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 333849008902 putative active site [active] 333849008903 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 333849008904 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 333849008905 Transposase; Region: DEDD_Tnp_IS110; pfam01548 333849008906 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 333849008907 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 333849008908 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 333849008909 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 333849008910 Transposase, Mutator family; Region: Transposase_mut; pfam00872 333849008911 MULE transposase domain; Region: MULE; pfam10551 333849008912 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 333849008913 catalytic residues [active] 333849008914 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 333849008915 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 333849008916 catalytic residues [active] 333849008917 catalytic nucleophile [active] 333849008918 Presynaptic Site I dimer interface [polypeptide binding]; other site 333849008919 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 333849008920 Synaptic Flat tetramer interface [polypeptide binding]; other site 333849008921 Synaptic Site I dimer interface [polypeptide binding]; other site 333849008922 DNA binding site [nucleotide binding] 333849008923 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 333849008924 DNA-binding interface [nucleotide binding]; DNA binding site 333849008925 PemK-like protein; Region: PemK; pfam02452 333849008926 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 333849008927 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 333849008928 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 333849008929 dimer interface [polypeptide binding]; other site 333849008930 ssDNA binding site [nucleotide binding]; other site 333849008931 tetramer (dimer of dimers) interface [polypeptide binding]; other site 333849008932 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 333849008933 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 333849008934 Transposase IS200 like; Region: Y1_Tnp; pfam01797 333849008935 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 333849008936 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 333849008937 Probable transposase; Region: OrfB_IS605; pfam01385 333849008938 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 333849008939 Domain of unknown function (DUF4349); Region: DUF4349; pfam14257 333849008940 DNA topoisomerase III; Provisional; Region: PRK07726 333849008941 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 333849008942 active site 333849008943 putative interdomain interaction site [polypeptide binding]; other site 333849008944 putative metal-binding site [ion binding]; other site 333849008945 putative nucleotide binding site [chemical binding]; other site 333849008946 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 333849008947 domain I; other site 333849008948 DNA binding groove [nucleotide binding] 333849008949 phosphate binding site [ion binding]; other site 333849008950 domain II; other site 333849008951 domain III; other site 333849008952 nucleotide binding site [chemical binding]; other site 333849008953 catalytic site [active] 333849008954 domain IV; other site