-- dump date 20140619_074407 -- class Genbank::misc_feature -- table misc_feature_note -- id note 768486000001 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098 768486000002 active site 768486000003 catalytic site [active] 768486000004 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 768486000005 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 768486000006 non-specific DNA binding site [nucleotide binding]; other site 768486000007 salt bridge; other site 768486000008 sequence-specific DNA binding site [nucleotide binding]; other site 768486000009 Conjugative transposon protein TcpC; Region: TpcC; pfam12642 768486000010 TcpE family; Region: TcpE; pfam12648 768486000011 AAA-like domain; Region: AAA_10; pfam12846 768486000012 Domain of unknown function DUF87; Region: DUF87; pfam01935 768486000013 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; pfam04610 768486000014 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 768486000015 Peptidase family M23; Region: Peptidase_M23; pfam01551 768486000016 DNA polymerase IV; Reviewed; Region: PRK03103 768486000017 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 768486000018 active site 768486000019 DNA binding site [nucleotide binding] 768486000020 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 768486000021 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 768486000022 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 768486000023 P-loop; other site 768486000024 Magnesium ion binding site [ion binding]; other site 768486000025 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 768486000026 Magnesium ion binding site [ion binding]; other site 768486000027 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768486000028 Coenzyme A binding pocket [chemical binding]; other site 768486000029 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 768486000030 non-specific DNA binding site [nucleotide binding]; other site 768486000031 salt bridge; other site 768486000032 sequence-specific DNA binding site [nucleotide binding]; other site 768486000033 Bacterial protein of unknown function (DUF961); Region: DUF961; pfam06125 768486000034 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 768486000035 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 768486000036 non-specific DNA binding site [nucleotide binding]; other site 768486000037 salt bridge; other site 768486000038 sequence-specific DNA binding site [nucleotide binding]; other site 768486000039 Replication initiation factor; Region: Rep_trans; pfam02486 768486000040 Pollen proteins Ole e I like; Region: Pollen_Ole_e_I; pfam01190 768486000041 Mga helix-turn-helix domain; Region: Mga; pfam05043 768486000042 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 768486000043 DNA-binding site [nucleotide binding]; DNA binding site 768486000044 RNA-binding motif; other site 768486000045 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 768486000046 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 768486000047 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 768486000048 Predicted membrane protein [Function unknown]; Region: COG2246 768486000049 GtrA-like protein; Region: GtrA; pfam04138 768486000050 Protein of unknown function (DUF1189); Region: DUF1189; pfam06691 768486000051 Phosphoglycerate Dehydrogenase, 2-hydroxyacid dehydrogenase family; Region: PGDH_1; cd12155 768486000052 glycerate dehydrogenase; Provisional; Region: PRK06932 768486000053 putative ligand binding site [chemical binding]; other site 768486000054 NAD binding site [chemical binding]; other site 768486000055 catalytic site [active] 768486000056 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 768486000057 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 768486000058 TrkA-N domain; Region: TrkA_N; pfam02254 768486000059 TrkA-C domain; Region: TrkA_C; pfam02080 768486000060 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 768486000061 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768486000062 active site 768486000063 phosphorylation site [posttranslational modification] 768486000064 intermolecular recognition site; other site 768486000065 dimerization interface [polypeptide binding]; other site 768486000066 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 768486000067 DNA binding residues [nucleotide binding] 768486000068 dimerization interface [polypeptide binding]; other site 768486000069 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 768486000070 Histidine kinase; Region: HisKA_3; pfam07730 768486000071 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768486000072 ATP binding site [chemical binding]; other site 768486000073 Mg2+ binding site [ion binding]; other site 768486000074 G-X-G motif; other site 768486000075 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 768486000076 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 768486000077 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 768486000078 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 768486000079 YceG-like family; Region: YceG; pfam02618 768486000080 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 768486000081 dimerization interface [polypeptide binding]; other site 768486000082 Beta-lactamase; Region: Beta-lactamase; pfam00144 768486000083 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 768486000084 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768486000085 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 768486000086 NAD(P) binding site [chemical binding]; other site 768486000087 active site 768486000088 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 768486000089 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 768486000090 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196 768486000091 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 768486000092 Probable Catalytic site; other site 768486000093 LicD family; Region: LicD; cl01378 768486000094 O-Antigen ligase; Region: Wzy_C; pfam04932 768486000095 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 768486000096 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 768486000097 active site 768486000098 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768486000099 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 768486000100 NAD(P) binding site [chemical binding]; other site 768486000101 active site 768486000102 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 768486000103 substrate binding site; other site 768486000104 dimer interface; other site 768486000105 AtlA is an autolysin found in Gram-positive lactic acid bacteria that degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. This family includes the AtlA and Aml...; Region: GH25_AtlA-like; cd06522 768486000106 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 768486000107 active site 768486000108 LicD family; Region: LicD; cl01378 768486000109 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 768486000110 active site 768486000111 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 768486000112 Bacterial sugar transferase; Region: Bac_transf; pfam02397 768486000113 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 768486000114 Myxococcus xanthus RfbC like proteins are required for O-antigen biosynthesis; Region: GT2_RfbC_Mx_like; cd04184 768486000115 Probable Catalytic site; other site 768486000116 metal-binding site 768486000117 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 768486000118 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 768486000119 Probable Catalytic site; other site 768486000120 metal-binding site 768486000121 Methyltransferase domain; Region: Methyltransf_23; pfam13489 768486000122 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768486000123 S-adenosylmethionine binding site [chemical binding]; other site 768486000124 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 768486000125 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 768486000126 Walker A/P-loop; other site 768486000127 ATP binding site [chemical binding]; other site 768486000128 Q-loop/lid; other site 768486000129 ABC transporter signature motif; other site 768486000130 Walker B; other site 768486000131 D-loop; other site 768486000132 H-loop/switch region; other site 768486000133 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 768486000134 putative carbohydrate binding site [chemical binding]; other site 768486000135 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 768486000136 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 768486000137 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 768486000138 MULE transposase domain; Region: MULE; pfam10551 768486000139 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 768486000140 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 768486000141 NADP binding site [chemical binding]; other site 768486000142 active site 768486000143 putative substrate binding site [chemical binding]; other site 768486000144 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 768486000145 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 768486000146 NAD binding site [chemical binding]; other site 768486000147 substrate binding site [chemical binding]; other site 768486000148 homodimer interface [polypeptide binding]; other site 768486000149 active site 768486000150 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 768486000151 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 768486000152 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 768486000153 substrate binding site; other site 768486000154 tetramer interface; other site 768486000155 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 768486000156 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196 768486000157 Probable Catalytic site; other site 768486000158 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 768486000159 active site 768486000160 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 768486000161 active site 768486000162 Glycosyltransferase like family; Region: Glyco_tranf_2_5; pfam13712 768486000163 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 768486000164 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 768486000165 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 768486000166 Mg++ binding site [ion binding]; other site 768486000167 putative catalytic motif [active] 768486000168 substrate binding site [chemical binding]; other site 768486000169 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 768486000170 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 768486000171 active site 768486000172 flavodoxin; Validated; Region: PRK07308 768486000173 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 768486000174 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 768486000175 WHG domain; Region: WHG; pfam13305 768486000176 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 768486000177 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 768486000178 Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527 768486000179 Predicted acetyltransferase involved in intracellular survival and related acetyltransferases [General function prediction only]; Region: Eis; COG4552 768486000180 Domain of unknown function (DUF3284); Region: DUF3284; pfam11687 768486000181 Protein of unknown function (DUF3188); Region: DUF3188; pfam11384 768486000182 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 768486000183 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 768486000184 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 768486000185 active site 768486000186 methionine cluster; other site 768486000187 phosphorylation site [posttranslational modification] 768486000188 metal binding site [ion binding]; metal-binding site 768486000189 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 768486000190 active site 768486000191 P-loop; other site 768486000192 phosphorylation site [posttranslational modification] 768486000193 potential frameshift: common BLAST hit: gi|29375591|ref|NP_814745.1| sigma-54 factor interaction domain-containing protein 768486000194 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 768486000195 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 768486000196 ATP binding site [chemical binding]; other site 768486000197 putative Mg++ binding site [ion binding]; other site 768486000198 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 768486000199 nucleotide binding region [chemical binding]; other site 768486000200 ATP-binding site [chemical binding]; other site 768486000201 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 768486000202 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 768486000203 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 768486000204 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 768486000205 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 768486000206 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 768486000207 FeoA domain; Region: FeoA; pfam04023 768486000208 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 768486000209 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 768486000210 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 768486000211 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 768486000212 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 768486000213 active site 768486000214 HIGH motif; other site 768486000215 nucleotide binding site [chemical binding]; other site 768486000216 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 768486000217 active site 768486000218 KMSKS motif; other site 768486000219 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 768486000220 tRNA binding surface [nucleotide binding]; other site 768486000221 anticodon binding site; other site 768486000222 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 768486000223 DivIVA protein; Region: DivIVA; pfam05103 768486000224 DivIVA domain; Region: DivI1A_domain; TIGR03544 768486000225 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 768486000226 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 768486000227 RNA binding surface [nucleotide binding]; other site 768486000228 YGGT family; Region: YGGT; pfam02325 768486000229 Protein of unknown function (DUF552); Region: DUF552; pfam04472 768486000230 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 768486000231 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 768486000232 catalytic residue [active] 768486000233 cell division protein FtsZ; Validated; Region: PRK09330 768486000234 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 768486000235 nucleotide binding site [chemical binding]; other site 768486000236 SulA interaction site; other site 768486000237 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 768486000238 Cell division protein FtsA; Region: FtsA; smart00842 768486000239 Cell division protein FtsA; Region: FtsA; pfam14450 768486000240 Domain of unknown function (DUF3484); Region: DUF3484; pfam11983 768486000241 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 768486000242 Cell division protein FtsQ; Region: FtsQ; pfam03799 768486000243 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 768486000244 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 768486000245 active site 768486000246 homodimer interface [polypeptide binding]; other site 768486000247 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 768486000248 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002 768486000249 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 768486000250 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 768486000251 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 768486000252 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 768486000253 Mg++ binding site [ion binding]; other site 768486000254 putative catalytic motif [active] 768486000255 putative substrate binding site [chemical binding]; other site 768486000256 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 768486000257 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 768486000258 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 768486000259 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 768486000260 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 768486000261 Cell division protein FtsL; Region: FtsL; cl11433 768486000262 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 768486000263 MraW methylase family; Region: Methyltransf_5; pfam01795 768486000264 cell division protein MraZ; Reviewed; Region: PRK00326 768486000265 MraZ protein; Region: MraZ; pfam02381 768486000266 MraZ protein; Region: MraZ; pfam02381 768486000267 Protein of unknown function (DUF3397); Region: DUF3397; pfam11877 768486000268 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 768486000269 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 768486000270 Cl binding site [ion binding]; other site 768486000271 oligomer interface [polypeptide binding]; other site 768486000272 Protein of unknown function (DUF4044); Region: DUF4044; pfam13253 768486000273 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 768486000274 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 768486000275 Walker A/P-loop; other site 768486000276 ATP binding site [chemical binding]; other site 768486000277 Q-loop/lid; other site 768486000278 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 768486000279 ABC transporter signature motif; other site 768486000280 Walker B; other site 768486000281 D-loop; other site 768486000282 H-loop/switch region; other site 768486000283 Arginine repressor [Transcription]; Region: ArgR; COG1438 768486000284 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 768486000285 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 768486000286 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 768486000287 S4 RNA-binding domain; Region: S4; smart00363 768486000288 RNA binding surface [nucleotide binding]; other site 768486000289 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 768486000290 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 768486000291 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 768486000292 substrate binding pocket [chemical binding]; other site 768486000293 chain length determination region; other site 768486000294 substrate-Mg2+ binding site; other site 768486000295 catalytic residues [active] 768486000296 aspartate-rich region 1; other site 768486000297 active site lid residues [active] 768486000298 aspartate-rich region 2; other site 768486000299 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 768486000300 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 768486000301 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 768486000302 generic binding surface II; other site 768486000303 generic binding surface I; other site 768486000304 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 768486000305 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14179 768486000306 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 768486000307 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 768486000308 homodimer interface [polypeptide binding]; other site 768486000309 NADP binding site [chemical binding]; other site 768486000310 substrate binding site [chemical binding]; other site 768486000311 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 768486000312 putative RNA binding site [nucleotide binding]; other site 768486000313 Asp23 family; Region: Asp23; pfam03780 768486000314 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 768486000315 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 768486000316 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 768486000317 active site 768486000318 Predicted membrane protein [Function unknown]; Region: COG2261 768486000319 Domain of unknown function (DUF956); Region: DUF956; pfam06115 768486000320 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 768486000321 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 768486000322 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 768486000323 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 768486000324 active pocket/dimerization site; other site 768486000325 active site 768486000326 phosphorylation site [posttranslational modification] 768486000327 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 768486000328 active site 768486000329 phosphorylation site [posttranslational modification] 768486000330 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 768486000331 active site 768486000332 phosphorylation site [posttranslational modification] 768486000333 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 768486000334 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768486000335 Walker A motif; other site 768486000336 ATP binding site [chemical binding]; other site 768486000337 Walker B motif; other site 768486000338 arginine finger; other site 768486000339 Transcriptional antiterminator [Transcription]; Region: COG3933 768486000340 PRD domain; Region: PRD; pfam00874 768486000341 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 768486000342 active pocket/dimerization site; other site 768486000343 active site 768486000344 phosphorylation site [posttranslational modification] 768486000345 PRD domain; Region: PRD; pfam00874 768486000346 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 768486000347 Acyltransferase family; Region: Acyl_transf_3; pfam01757 768486000348 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 768486000349 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 768486000350 DNA-binding site [nucleotide binding]; DNA binding site 768486000351 RNA-binding motif; other site 768486000352 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 768486000353 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 768486000354 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 768486000355 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 768486000356 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 768486000357 active site 768486000358 Phage holin; Region: Phage_holin_5; pfam06946 768486000359 Domain of unknown function (DUF2479); Region: DUF2479; pfam10651 768486000360 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 768486000361 active site 768486000362 catalytic triad [active] 768486000363 oxyanion hole [active] 768486000364 Prophage endopeptidase tail; Region: Prophage_tail; pfam06605 768486000365 Phage tail protein; Region: Sipho_tail; pfam05709 768486000366 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 768486000367 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 768486000368 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 768486000369 N-acetyl-D-glucosamine binding site [chemical binding]; other site 768486000370 catalytic residue [active] 768486000371 HeH/LEM domain; Region: HeH; pfam12949 768486000372 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 768486000373 HeH/LEM domain; Region: HeH; pfam12949 768486000374 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 768486000375 Phage capsid family; Region: Phage_capsid; pfam05065 768486000376 ATP-dependent Clp protease proteolytic subunit; Provisional; Region: PRK14512 768486000377 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 768486000378 oligomer interface [polypeptide binding]; other site 768486000379 active site residues [active] 768486000380 Phage-related protein [Function unknown]; Region: COG4695 768486000381 Phage portal protein; Region: Phage_portal; pfam04860 768486000382 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 768486000383 Phage terminase, small subunit; Region: Terminase_4; cl01525 768486000384 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 768486000385 active site 768486000386 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 768486000387 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 768486000388 ORF6C domain; Region: ORF6C; pfam10552 768486000389 Protein of unknown function (DUF1642); Region: DUF1642; pfam07852 768486000390 YopX protein; Region: YopX; pfam09643 768486000391 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768486000392 AAA domain; Region: AAA_22; pfam13401 768486000393 Walker A motif; other site 768486000394 ATP binding site [chemical binding]; other site 768486000395 Walker B motif; other site 768486000396 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 768486000397 Helix-turn-helix domain; Region: HTH_36; pfam13730 768486000398 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 768486000399 RecT family; Region: RecT; cl04285 768486000400 YqaJ-like viral recombinase domain; Region: YqaJ; cl09232 768486000401 Uncharacterized protein conserved in bacteria (DUF2321); Region: DUF2321; pfam10083 768486000402 Protein of unknown function (DUF2829); Region: DUF2829; pfam11195 768486000403 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 768486000404 non-specific DNA binding site [nucleotide binding]; other site 768486000405 salt bridge; other site 768486000406 sequence-specific DNA binding site [nucleotide binding]; other site 768486000407 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 768486000408 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 768486000409 non-specific DNA binding site [nucleotide binding]; other site 768486000410 salt bridge; other site 768486000411 sequence-specific DNA binding site [nucleotide binding]; other site 768486000412 Domain of unknown function (DUF955); Region: DUF955; pfam06114 768486000413 DNA polymerase III subunit epsilon; Validated; Region: PRK06195 768486000414 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 768486000415 active site 768486000416 catalytic site [active] 768486000417 substrate binding site [chemical binding]; other site 768486000418 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 768486000419 Dimer interface [polypeptide binding]; other site 768486000420 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 768486000421 integrase; Provisional; Region: PRK09692 768486000422 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 768486000423 Int/Topo IB signature motif; other site 768486000424 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 768486000425 Protein of unknown function (DUF464); Region: DUF464; pfam04327 768486000426 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 768486000427 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 768486000428 active site 768486000429 Fe-S cluster binding site [ion binding]; other site 768486000430 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 768486000431 Sulfate transporter family; Region: Sulfate_transp; pfam00916 768486000432 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 768486000433 Predicted membrane protein [Function unknown]; Region: COG3759 768486000434 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 768486000435 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768486000436 S-adenosylmethionine binding site [chemical binding]; other site 768486000437 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465 768486000438 Catalytic site [active] 768486000439 potential frameshift: common BLAST hit: gi|389867942|ref|YP_006375365.1| TerC family integral membrane protein 768486000440 potential frameshift: common BLAST hit: gi|389867942|ref|YP_006375365.1| TerC family integral membrane protein 768486000441 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 768486000442 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 768486000443 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 768486000444 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 768486000445 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 768486000446 Protein of unknown function (DUF975); Region: DUF975; cl10504 768486000447 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 768486000448 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 768486000449 oligomer interface [polypeptide binding]; other site 768486000450 active site 768486000451 metal binding site [ion binding]; metal-binding site 768486000452 D-alanyl-lipoteichoic acid biosynthesis protein DltD; Region: LTA_DltD; TIGR04092 768486000453 DltD N-terminal region; Region: DltD_N; pfam04915 768486000454 DltD central region; Region: DltD_M; pfam04918 768486000455 DltD C-terminal region; Region: DltD_C; pfam04914 768486000456 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087 768486000457 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091 768486000458 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 768486000459 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 768486000460 acyl-activating enzyme (AAE) consensus motif; other site 768486000461 AMP binding site [chemical binding]; other site 768486000462 D-Ala-teichoic acid biosynthesis protein; Region: DUF3687; pfam12459 768486000463 potential frameshift: common BLAST hit: gi|389867932|ref|YP_006375355.1| ABC superfamily ATP binding cassette transporter, membrane protein 768486000464 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 768486000465 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 768486000466 Walker A/P-loop; other site 768486000467 ATP binding site [chemical binding]; other site 768486000468 Q-loop/lid; other site 768486000469 ABC transporter signature motif; other site 768486000470 Walker B; other site 768486000471 D-loop; other site 768486000472 H-loop/switch region; other site 768486000473 potential frameshift: common BLAST hit: gi|332686125|ref|YP_004455899.1| ribonucleotide reductase of class III (anaerobic), large subunit 768486000474 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804 768486000475 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 768486000476 potential frameshift: common BLAST hit: gi|389867928|ref|YP_006375351.1| DNA-directed DNA polymerase IV 768486000477 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 768486000478 DNA polymerase IV; Validated; Region: PRK02406 768486000479 active site 768486000480 DNA binding site [nucleotide binding] 768486000481 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 768486000482 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 768486000483 CoA binding domain; Region: CoA_binding; pfam02629 768486000484 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 768486000485 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768486000486 Walker A/P-loop; other site 768486000487 ATP binding site [chemical binding]; other site 768486000488 Q-loop/lid; other site 768486000489 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 768486000490 ABC transporter signature motif; other site 768486000491 Walker B; other site 768486000492 D-loop; other site 768486000493 ABC transporter; Region: ABC_tran_2; pfam12848 768486000494 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 768486000495 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 768486000496 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 768486000497 Walker A/P-loop; other site 768486000498 ATP binding site [chemical binding]; other site 768486000499 Q-loop/lid; other site 768486000500 ABC transporter signature motif; other site 768486000501 Walker B; other site 768486000502 D-loop; other site 768486000503 H-loop/switch region; other site 768486000504 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 768486000505 FtsX-like permease family; Region: FtsX; pfam02687 768486000506 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 768486000507 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768486000508 active site 768486000509 phosphorylation site [posttranslational modification] 768486000510 intermolecular recognition site; other site 768486000511 dimerization interface [polypeptide binding]; other site 768486000512 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 768486000513 DNA binding site [nucleotide binding] 768486000514 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768486000515 dimer interface [polypeptide binding]; other site 768486000516 phosphorylation site [posttranslational modification] 768486000517 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 768486000518 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768486000519 ATP binding site [chemical binding]; other site 768486000520 Mg2+ binding site [ion binding]; other site 768486000521 G-X-G motif; other site 768486000522 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 768486000523 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 768486000524 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768486000525 Walker A/P-loop; other site 768486000526 ATP binding site [chemical binding]; other site 768486000527 Q-loop/lid; other site 768486000528 ABC transporter signature motif; other site 768486000529 Walker B; other site 768486000530 D-loop; other site 768486000531 H-loop/switch region; other site 768486000532 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 768486000533 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 768486000534 putative Zn2+ binding site [ion binding]; other site 768486000535 putative DNA binding site [nucleotide binding]; other site 768486000536 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 768486000537 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 768486000538 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 768486000539 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768486000540 dimer interface [polypeptide binding]; other site 768486000541 conserved gate region; other site 768486000542 putative PBP binding loops; other site 768486000543 ABC-ATPase subunit interface; other site 768486000544 2-aminoethylphosphonate transport system permease PhnU; Provisional; Region: PRK15050 768486000545 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768486000546 dimer interface [polypeptide binding]; other site 768486000547 conserved gate region; other site 768486000548 putative PBP binding loops; other site 768486000549 ABC-ATPase subunit interface; other site 768486000550 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 768486000551 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 768486000552 Walker A/P-loop; other site 768486000553 ATP binding site [chemical binding]; other site 768486000554 Q-loop/lid; other site 768486000555 ABC transporter signature motif; other site 768486000556 Walker B; other site 768486000557 D-loop; other site 768486000558 H-loop/switch region; other site 768486000559 TOBE domain; Region: TOBE_2; pfam08402 768486000560 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 768486000561 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 768486000562 non-specific DNA binding site [nucleotide binding]; other site 768486000563 salt bridge; other site 768486000564 sequence-specific DNA binding site [nucleotide binding]; other site 768486000565 Yhdh and yhfp-like putative quinone oxidoreductases; Region: MDR_yhdh_yhfp; cd05280 768486000566 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 768486000567 NADP binding site [chemical binding]; other site 768486000568 dimer interface [polypeptide binding]; other site 768486000569 DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410 768486000570 phosphopantothenoylcysteine decarboxylase; Validated; Region: PRK07313 768486000571 Flavoprotein; Region: Flavoprotein; pfam02441 768486000572 Predicted membrane protein [Function unknown]; Region: COG4684 768486000573 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 768486000574 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 768486000575 NADH(P)-binding; Region: NAD_binding_10; pfam13460 768486000576 NAD(P) binding site [chemical binding]; other site 768486000577 putative active site [active] 768486000578 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 768486000579 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 768486000580 NAD(P) binding site [chemical binding]; other site 768486000581 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1755 768486000582 fumarate reductase flavoprotein subunit; Validated; Region: PRK06481 768486000583 L-aspartate oxidase; Provisional; Region: PRK06175 768486000584 Enterocin A Immunity; Region: EntA_Immun; pfam08951 768486000585 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 768486000586 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768486000587 Coenzyme A binding pocket [chemical binding]; other site 768486000588 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 768486000589 FAD binding domain; Region: FAD_binding_4; pfam01565 768486000590 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 768486000591 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 768486000592 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 768486000593 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 768486000594 active site 768486000595 putative catalytic site [active] 768486000596 DNA binding site [nucleotide binding] 768486000597 putative phosphate binding site [ion binding]; other site 768486000598 metal binding site A [ion binding]; metal-binding site 768486000599 AP binding site [nucleotide binding]; other site 768486000600 metal binding site B [ion binding]; metal-binding site 768486000601 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 768486000602 active site 768486000603 catalytic site [active] 768486000604 substrate binding site [chemical binding]; other site 768486000605 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 768486000606 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768486000607 Coenzyme A binding pocket [chemical binding]; other site 768486000608 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 768486000609 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 768486000610 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 768486000611 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 768486000612 ligand binding site [chemical binding]; other site 768486000613 active site 768486000614 UGI interface [polypeptide binding]; other site 768486000615 catalytic site [active] 768486000616 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 768486000617 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 768486000618 active site 768486000619 motif I; other site 768486000620 motif II; other site 768486000621 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 768486000622 Tubby C 2; Region: Tub_2; cl02043 768486000623 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768486000624 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 768486000625 Coenzyme A binding pocket [chemical binding]; other site 768486000626 cxxc_20_cxxc protein; Region: cxxc_20_cxxc; TIGR04104 768486000627 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 768486000628 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 768486000629 putative metal binding site [ion binding]; other site 768486000630 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 768486000631 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 768486000632 putative substrate binding pocket [chemical binding]; other site 768486000633 AC domain interface; other site 768486000634 catalytic triad [active] 768486000635 AB domain interface; other site 768486000636 interchain disulfide; other site 768486000637 Predicted membrane protein [Function unknown]; Region: COG3817 768486000638 Protein of unknown function (DUF979); Region: DUF979; pfam06166 768486000639 Protein of unknown function (DUF969); Region: DUF969; pfam06149 768486000640 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 768486000641 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 768486000642 NrdI Flavodoxin like; Region: Flavodoxin_NdrI; cl17293 768486000643 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 768486000644 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 768486000645 active site turn [active] 768486000646 phosphorylation site [posttranslational modification] 768486000647 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 768486000648 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 768486000649 HPr interaction site; other site 768486000650 glycerol kinase (GK) interaction site [polypeptide binding]; other site 768486000651 active site 768486000652 phosphorylation site [posttranslational modification] 768486000653 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 768486000654 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 768486000655 putative active site [active] 768486000656 Uncharacterized conserved protein [Function unknown]; Region: COG3589 768486000657 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 768486000658 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 768486000659 catalytic core [active] 768486000660 potential frameshift: common BLAST hit: gi|29377198|ref|NP_816352.1| ABC transporter ATP-binding protein 768486000661 potential frameshift: common BLAST hit: gi|389867836|ref|YP_006375259.1| glycerate kinase 768486000662 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 768486000663 Glycerate kinase family; Region: Gly_kinase; cl00841 768486000664 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 768486000665 glutaminase A; Region: Gln_ase; TIGR03814 768486000666 glutamate:gamma-aminobutyrate antiporter; Region: 2A0307_GadC; TIGR00910 768486000667 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 768486000668 Predicted membrane protein [Function unknown]; Region: COG2364 768486000669 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 768486000670 Domain of unknown function (DUF305); Region: DUF305; cl17794 768486000671 Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553 768486000672 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 768486000673 amidohydrolase; Region: amidohydrolases; TIGR01891 768486000674 metal binding site [ion binding]; metal-binding site 768486000675 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 768486000676 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 768486000677 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768486000678 dimer interface [polypeptide binding]; other site 768486000679 conserved gate region; other site 768486000680 ABC-ATPase subunit interface; other site 768486000681 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 768486000682 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 768486000683 Walker A/P-loop; other site 768486000684 ATP binding site [chemical binding]; other site 768486000685 Q-loop/lid; other site 768486000686 ABC transporter signature motif; other site 768486000687 Walker B; other site 768486000688 D-loop; other site 768486000689 H-loop/switch region; other site 768486000690 NIL domain; Region: NIL; pfam09383 768486000691 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 768486000692 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 768486000693 motif II; other site 768486000694 magnesium-transporting ATPase; Provisional; Region: PRK15122 768486000695 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 768486000696 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 768486000697 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 768486000698 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 768486000699 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 768486000700 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 768486000701 active site 768486000702 multimer interface [polypeptide binding]; other site 768486000703 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 768486000704 non-specific DNA binding site [nucleotide binding]; other site 768486000705 salt bridge; other site 768486000706 sequence-specific DNA binding site [nucleotide binding]; other site 768486000707 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 768486000708 Sulfatase; Region: Sulfatase; pfam00884 768486000709 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 768486000710 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 768486000711 active site 768486000712 metal binding site [ion binding]; metal-binding site 768486000713 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 768486000714 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 768486000715 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 768486000716 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 768486000717 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 768486000718 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 768486000719 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 768486000720 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768486000721 dimer interface [polypeptide binding]; other site 768486000722 conserved gate region; other site 768486000723 putative PBP binding loops; other site 768486000724 ABC-ATPase subunit interface; other site 768486000725 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768486000726 dimer interface [polypeptide binding]; other site 768486000727 conserved gate region; other site 768486000728 putative PBP binding loops; other site 768486000729 ABC-ATPase subunit interface; other site 768486000730 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 768486000731 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 768486000732 Walker A/P-loop; other site 768486000733 ATP binding site [chemical binding]; other site 768486000734 Q-loop/lid; other site 768486000735 ABC transporter signature motif; other site 768486000736 Walker B; other site 768486000737 D-loop; other site 768486000738 H-loop/switch region; other site 768486000739 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 768486000740 beta-galactosidase; Region: BGL; TIGR03356 768486000741 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 768486000742 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 768486000743 Substrate-binding site [chemical binding]; other site 768486000744 Substrate specificity [chemical binding]; other site 768486000745 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014 768486000746 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 768486000747 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 768486000748 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 768486000749 substrate binding site [chemical binding]; other site 768486000750 ATP binding site [chemical binding]; other site 768486000751 conserved hypothetical protein EF_0839/AHA_3917; Region: EF_0839; TIGR03581 768486000752 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 768486000753 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 768486000754 catalytic residue [active] 768486000755 probable amidohydrolase EF_0837/AHA_3915; Region: EF_0837; TIGR03583 768486000756 Metallo-dependent hydrolases, subgroup B is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_B; cd01307 768486000757 active site 768486000758 Uncharacterized conserved protein [Function unknown]; Region: COG3589 768486000759 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 768486000760 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 768486000761 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 768486000762 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 768486000763 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 768486000764 DNA-binding site [nucleotide binding]; DNA binding site 768486000765 UTRA domain; Region: UTRA; pfam07702 768486000766 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 768486000767 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 768486000768 beta-galactosidase; Region: BGL; TIGR03356 768486000769 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 768486000770 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 768486000771 active site turn [active] 768486000772 phosphorylation site [posttranslational modification] 768486000773 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 768486000774 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 768486000775 HPr interaction site; other site 768486000776 glycerol kinase (GK) interaction site [polypeptide binding]; other site 768486000777 active site 768486000778 phosphorylation site [posttranslational modification] 768486000779 transcriptional antiterminator BglG; Provisional; Region: PRK09772 768486000780 CAT RNA binding domain; Region: CAT_RBD; smart01061 768486000781 PRD domain; Region: PRD; pfam00874 768486000782 PRD domain; Region: PRD; pfam00874 768486000783 Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165 768486000784 active site 768486000785 catalytic site [active] 768486000786 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537 768486000787 homodimer interface [polypeptide binding]; other site 768486000788 chemical substrate binding site [chemical binding]; other site 768486000789 oligomer interface [polypeptide binding]; other site 768486000790 metal binding site [ion binding]; metal-binding site 768486000791 benzoate transport; Region: 2A0115; TIGR00895 768486000792 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768486000793 putative substrate translocation pore; other site 768486000794 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 768486000795 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 768486000796 putative active site cavity [active] 768486000797 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 768486000798 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 768486000799 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 768486000800 metal ion-dependent adhesion site (MIDAS); other site 768486000801 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 768486000802 domain interaction interfaces [polypeptide binding]; other site 768486000803 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 768486000804 HTH domain; Region: HTH_11; pfam08279 768486000805 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cd00133 768486000806 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 768486000807 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 768486000808 Walker A/P-loop; other site 768486000809 ATP binding site [chemical binding]; other site 768486000810 Q-loop/lid; other site 768486000811 ABC transporter signature motif; other site 768486000812 Walker B; other site 768486000813 D-loop; other site 768486000814 H-loop/switch region; other site 768486000815 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 768486000816 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 768486000817 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 768486000818 Walker A/P-loop; other site 768486000819 ATP binding site [chemical binding]; other site 768486000820 Q-loop/lid; other site 768486000821 ABC transporter signature motif; other site 768486000822 Walker B; other site 768486000823 D-loop; other site 768486000824 H-loop/switch region; other site 768486000825 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 768486000826 DNA binding residues [nucleotide binding] 768486000827 agmatine deiminase; Provisional; Region: PRK13551 768486000828 agmatine deiminase; Region: agmatine_aguA; TIGR03380 768486000829 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 768486000830 putrescine carbamoyltransferase; Provisional; Region: PRK02255 768486000831 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 768486000832 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 768486000833 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 768486000834 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 768486000835 DNA binding residues [nucleotide binding] 768486000836 dimerization interface [polypeptide binding]; other site 768486000837 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 768486000838 active pocket/dimerization site; other site 768486000839 active site 768486000840 phosphorylation site [posttranslational modification] 768486000841 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 768486000842 PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609 768486000843 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 768486000844 active site 768486000845 phosphorylation site [posttranslational modification] 768486000846 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 768486000847 Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301 768486000848 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 768486000849 tagatose-6-phosphate kinase; Region: lacC; TIGR01231 768486000850 putative substrate binding site [chemical binding]; other site 768486000851 putative ATP binding site [chemical binding]; other site 768486000852 potential frameshift: common BLAST hit: gi|29376351|ref|NP_815505.1| tagatose 1,6-diphosphate aldolase 768486000853 putative sugar isomerase, AgaS family; Region: agaS_fam; TIGR02815 768486000854 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 768486000855 dimer interface [polypeptide binding]; other site 768486000856 active site 768486000857 AgaS-like protein. AgaS contains a SIS (Sugar ISomerase) domain which is found in many phosphosugar isomerases and phosphosugar binding proteins. AgaS is a putative isomerase in Escherichia coli. It is similar to the glucosamine-6-phosphate synthases; Region: SIS_AgaS_like; cd05010 768486000858 putative active site [active] 768486000859 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 768486000860 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 768486000861 DNA-binding site [nucleotide binding]; DNA binding site 768486000862 UTRA domain; Region: UTRA; pfam07702 768486000863 potential frameshift: common BLAST hit: gi|220930091|ref|YP_002507000.1| SMC domain-containing protein 768486000864 sporadically distributed protein, TIGR04141 family; Region: TIGR04141 768486000865 AAA domain; Region: AAA_11; pfam13086 768486000866 Part of AAA domain; Region: AAA_19; pfam13245 768486000867 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 768486000868 AAA domain; Region: AAA_12; pfam13087 768486000869 Protein of unknown function (DUF2726); Region: DUF2726; pfam10881 768486000870 potential frameshift: common BLAST hit: gi|194450167|ref|YP_002045460.1| helicase c2 768486000871 Abortive infection C-terminus; Region: Abi_C; pfam14355 768486000872 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 768486000873 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 768486000874 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 768486000875 non-specific DNA binding site [nucleotide binding]; other site 768486000876 salt bridge; other site 768486000877 sequence-specific DNA binding site [nucleotide binding]; other site 768486000878 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 768486000879 non-specific DNA binding site [nucleotide binding]; other site 768486000880 salt bridge; other site 768486000881 sequence-specific DNA binding site [nucleotide binding]; other site 768486000882 CHC2 zinc finger; Region: zf-CHC2; cl17510 768486000883 Helix-turn-helix domain; Region: HTH_17; pfam12728 768486000884 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 768486000885 non-specific DNA binding site [nucleotide binding]; other site 768486000886 salt bridge; other site 768486000887 sequence-specific DNA binding site [nucleotide binding]; other site 768486000888 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 768486000889 Int/Topo IB signature motif; other site 768486000890 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 768486000891 FeS assembly protein SufB; Region: sufB; TIGR01980 768486000892 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 768486000893 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 768486000894 trimerization site [polypeptide binding]; other site 768486000895 active site 768486000896 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 768486000897 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 768486000898 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 768486000899 catalytic residue [active] 768486000900 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 768486000901 FeS assembly protein SufD; Region: sufD; TIGR01981 768486000902 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 768486000903 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 768486000904 Walker A/P-loop; other site 768486000905 ATP binding site [chemical binding]; other site 768486000906 Q-loop/lid; other site 768486000907 ABC transporter signature motif; other site 768486000908 Walker B; other site 768486000909 D-loop; other site 768486000910 H-loop/switch region; other site 768486000911 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 768486000912 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 768486000913 potential frameshift: common BLAST hit: gi|389867756|ref|YP_006375179.1| metal ion ABC superfamily ATP binding cassette transporter 768486000914 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768486000915 ABC-ATPase subunit interface; other site 768486000916 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 768486000917 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 768486000918 Walker A/P-loop; other site 768486000919 ATP binding site [chemical binding]; other site 768486000920 Q-loop/lid; other site 768486000921 ABC transporter signature motif; other site 768486000922 Walker B; other site 768486000923 D-loop; other site 768486000924 H-loop/switch region; other site 768486000925 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 768486000926 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 768486000927 lipoyl attachment site [posttranslational modification]; other site 768486000928 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 768486000929 ArsC family; Region: ArsC; pfam03960 768486000930 putative ArsC-like catalytic residues; other site 768486000931 putative TRX-like catalytic residues [active] 768486000932 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 768486000933 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768486000934 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768486000935 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 768486000936 dimerization interface [polypeptide binding]; other site 768486000937 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 768486000938 C4-dicarboxylate transporters of the Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_C4-dicarb_trans; cd09325 768486000939 gating phenylalanine in ion channel; other site 768486000940 Predicted membrane protein [Function unknown]; Region: COG2855 768486000941 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 768486000942 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 768486000943 DNA binding site [nucleotide binding] 768486000944 active site 768486000945 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 768486000946 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 768486000947 Ligand binding site; other site 768486000948 Putative Catalytic site; other site 768486000949 DXD motif; other site 768486000950 Mga helix-turn-helix domain; Region: Mga; pfam05043 768486000951 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 768486000952 active site 768486000953 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 768486000954 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 768486000955 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 768486000956 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 768486000957 dimer interface [polypeptide binding]; other site 768486000958 active site 768486000959 glycine-pyridoxal phosphate binding site [chemical binding]; other site 768486000960 folate binding site [chemical binding]; other site 768486000961 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 768486000962 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 768486000963 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 768486000964 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768486000965 S-adenosylmethionine binding site [chemical binding]; other site 768486000966 peptide chain release factor 1; Validated; Region: prfA; PRK00591 768486000967 This domain is found in peptide chain release factors; Region: PCRF; smart00937 768486000968 RF-1 domain; Region: RF-1; pfam00472 768486000969 thymidine kinase; Provisional; Region: PRK04296 768486000970 Methyltransferase domain; Region: Methyltransf_23; pfam13489 768486000971 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768486000972 S-adenosylmethionine binding site [chemical binding]; other site 768486000973 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 768486000974 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 768486000975 Catalytic site [active] 768486000976 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 768486000977 Uncharacterized BCR, COG1636; Region: DUF208; pfam02677 768486000978 potential frameshift: common BLAST hit: gi|29377045|ref|NP_816199.1| cation transporter 768486000979 CAAX protease self-immunity; Region: Abi; pfam02517 768486000980 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 768486000981 non-specific DNA binding site [nucleotide binding]; other site 768486000982 salt bridge; other site 768486000983 sequence-specific DNA binding site [nucleotide binding]; other site 768486000984 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 768486000985 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 768486000986 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 768486000987 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 768486000988 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 768486000989 catalytic triad [active] 768486000990 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 768486000991 Bacteriophage peptidoglycan hydrolase; Region: Amidase_5; pfam05382 768486000992 AAA-like domain; Region: AAA_10; pfam12846 768486000993 PrgI family protein; Region: PrgI; pfam12666 768486000994 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 768486000995 Cna protein B-type domain; Region: Cna_B; pfam05738 768486000996 Cna protein B-type domain; Region: Cna_B; pfam05738 768486000997 Cna protein B-type domain; Region: Cna_B; pfam05738 768486000998 Cna protein B-type domain; Region: Cna_B; pfam05738 768486000999 2-hydroxycarboxylate transporter family; Region: 2HCT; cl01386 768486001000 Sugar transport protein; Region: Sugar_transport; pfam06800 768486001001 D-ribose pyranase; Provisional; Region: PRK11797 768486001002 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 768486001003 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 768486001004 substrate binding site [chemical binding]; other site 768486001005 dimer interface [polypeptide binding]; other site 768486001006 ATP binding site [chemical binding]; other site 768486001007 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 768486001008 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 768486001009 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 768486001010 Beta-lactamase; Region: Beta-lactamase; pfam00144 768486001011 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 768486001012 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 768486001013 active site 768486001014 metal binding site [ion binding]; metal-binding site 768486001015 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 768486001016 active site 768486001017 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 768486001018 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 768486001019 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 768486001020 Walker A/P-loop; other site 768486001021 ATP binding site [chemical binding]; other site 768486001022 Q-loop/lid; other site 768486001023 ABC transporter signature motif; other site 768486001024 Walker B; other site 768486001025 D-loop; other site 768486001026 H-loop/switch region; other site 768486001027 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 768486001028 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 768486001029 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768486001030 Walker A/P-loop; other site 768486001031 ATP binding site [chemical binding]; other site 768486001032 Q-loop/lid; other site 768486001033 ABC transporter signature motif; other site 768486001034 Walker B; other site 768486001035 D-loop; other site 768486001036 H-loop/switch region; other site 768486001037 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 768486001038 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 768486001039 Acyl carrier protein phosphodiesterase [Lipid metabolism]; Region: AcpD; COG1182 768486001040 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 768486001041 Domain of unknown function DUF20; Region: UPF0118; pfam01594 768486001042 PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; cl01516 768486001043 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 768486001044 Sulfatase; Region: Sulfatase; pfam00884 768486001045 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 768486001046 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 768486001047 homodimer interface [polypeptide binding]; other site 768486001048 NAD binding pocket [chemical binding]; other site 768486001049 ATP binding pocket [chemical binding]; other site 768486001050 Mg binding site [ion binding]; other site 768486001051 active-site loop [active] 768486001052 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 768486001053 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 768486001054 active site 768486001055 Domain of unknown function (DUF1827); Region: DUF1827; pfam08860 768486001056 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 768486001057 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 768486001058 DNA binding residues [nucleotide binding] 768486001059 dimer interface [polypeptide binding]; other site 768486001060 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 768486001061 potential frameshift: common BLAST hit: gi|389869533|ref|YP_006376956.1| LacI family transcriptional regulator 768486001062 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 768486001063 Transcriptional regulators [Transcription]; Region: PurR; COG1609 768486001064 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 768486001065 DNA binding site [nucleotide binding] 768486001066 domain linker motif; other site 768486001067 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 768486001068 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 768486001069 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 768486001070 ring oligomerisation interface [polypeptide binding]; other site 768486001071 ATP/Mg binding site [chemical binding]; other site 768486001072 stacking interactions; other site 768486001073 hinge regions; other site 768486001074 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 768486001075 oligomerisation interface [polypeptide binding]; other site 768486001076 mobile loop; other site 768486001077 roof hairpin; other site 768486001078 CAAX protease self-immunity; Region: Abi; pfam02517 768486001079 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 768486001080 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 768486001081 YycH protein; Region: YycI; pfam09648 768486001082 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863 768486001083 YycH protein; Region: YycH; pfam07435 768486001084 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 768486001085 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 768486001086 dimerization interface [polypeptide binding]; other site 768486001087 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 768486001088 putative active site [active] 768486001089 heme pocket [chemical binding]; other site 768486001090 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768486001091 dimer interface [polypeptide binding]; other site 768486001092 phosphorylation site [posttranslational modification] 768486001093 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768486001094 ATP binding site [chemical binding]; other site 768486001095 Mg2+ binding site [ion binding]; other site 768486001096 G-X-G motif; other site 768486001097 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 768486001098 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768486001099 active site 768486001100 phosphorylation site [posttranslational modification] 768486001101 intermolecular recognition site; other site 768486001102 dimerization interface [polypeptide binding]; other site 768486001103 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 768486001104 DNA binding site [nucleotide binding] 768486001105 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 768486001106 EDD domain protein, DegV family; Region: DegV; TIGR00762 768486001107 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 768486001108 Tocopherol cyclase; Region: Tocopherol_cycl; cl14571 768486001109 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 768486001110 potential frameshift: common BLAST hit: gi|29377126|ref|NP_816280.1| glycine betaine/L-proline ABC transporter glycine 768486001111 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 768486001112 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 768486001113 Walker A/P-loop; other site 768486001114 ATP binding site [chemical binding]; other site 768486001115 Q-loop/lid; other site 768486001116 ABC transporter signature motif; other site 768486001117 Walker B; other site 768486001118 D-loop; other site 768486001119 H-loop/switch region; other site 768486001120 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 768486001121 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 768486001122 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 768486001123 DNA-binding site [nucleotide binding]; DNA binding site 768486001124 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 768486001125 TrkA-C domain; Region: TrkA_C; pfam02080 768486001126 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 768486001127 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 768486001128 G1 box; other site 768486001129 GTP/Mg2+ binding site [chemical binding]; other site 768486001130 Switch I region; other site 768486001131 G2 box; other site 768486001132 G3 box; other site 768486001133 Switch II region; other site 768486001134 G4 box; other site 768486001135 G5 box; other site 768486001136 Nucleoside recognition; Region: Gate; pfam07670 768486001137 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 768486001138 Nucleoside recognition; Region: Gate; pfam07670 768486001139 This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899 768486001140 FeoA domain; Region: FeoA; pfam04023 768486001141 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 768486001142 catalytic residues [active] 768486001143 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07306 768486001144 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 768486001145 Class I ribonucleotide reductase; Region: RNR_I; cd01679 768486001146 active site 768486001147 dimer interface [polypeptide binding]; other site 768486001148 catalytic residues [active] 768486001149 effector binding site; other site 768486001150 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 768486001151 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 768486001152 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 768486001153 dimer interface [polypeptide binding]; other site 768486001154 putative radical transfer pathway; other site 768486001155 diiron center [ion binding]; other site 768486001156 tyrosyl radical; other site 768486001157 hypothetical protein; Provisional; Region: PRK02947 768486001158 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 768486001159 putative active site [active] 768486001160 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 768486001161 PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609 768486001162 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 768486001163 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 768486001164 active pocket/dimerization site; other site 768486001165 active site 768486001166 phosphorylation site [posttranslational modification] 768486001167 PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830 768486001168 active site 768486001169 phosphorylation site [posttranslational modification] 768486001170 Alpha-L-fucosidase; Region: Alpha_L_fucos; pfam01120 768486001171 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 768486001172 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 768486001173 nucleotide binding site [chemical binding]; other site 768486001174 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 768486001175 L-fucose isomerase; Provisional; Region: fucI; PRK10991 768486001176 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 768486001177 hexamer (dimer of trimers) interface [polypeptide binding]; other site 768486001178 trimer interface [polypeptide binding]; other site 768486001179 substrate binding site [chemical binding]; other site 768486001180 Mn binding site [ion binding]; other site 768486001181 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 768486001182 intersubunit interface [polypeptide binding]; other site 768486001183 active site 768486001184 Zn2+ binding site [ion binding]; other site 768486001185 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 768486001186 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 768486001187 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 768486001188 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 768486001189 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 768486001190 substrate binding site [chemical binding]; other site 768486001191 hexamer interface [polypeptide binding]; other site 768486001192 metal binding site [ion binding]; metal-binding site 768486001193 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 768486001194 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 768486001195 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 768486001196 active site 768486001197 P-loop; other site 768486001198 phosphorylation site [posttranslational modification] 768486001199 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 768486001200 active site 768486001201 phosphorylation site [posttranslational modification] 768486001202 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 768486001203 active site 768486001204 P-loop; other site 768486001205 phosphorylation site [posttranslational modification] 768486001206 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 768486001207 active site 768486001208 phosphorylation site [posttranslational modification] 768486001209 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 768486001210 HTH domain; Region: HTH_11; pfam08279 768486001211 PRD domain; Region: PRD; pfam00874 768486001212 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 768486001213 active site 768486001214 P-loop; other site 768486001215 phosphorylation site [posttranslational modification] 768486001216 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 768486001217 Domain of unknown function DUF20; Region: UPF0118; pfam01594 768486001218 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 768486001219 MgtC family; Region: MgtC; pfam02308 768486001220 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 768486001221 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 768486001222 active site 768486001223 trimer interface [polypeptide binding]; other site 768486001224 allosteric site; other site 768486001225 active site lid [active] 768486001226 hexamer (dimer of trimers) interface [polypeptide binding]; other site 768486001227 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 768486001228 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768486001229 Walker A/P-loop; other site 768486001230 ATP binding site [chemical binding]; other site 768486001231 Q-loop/lid; other site 768486001232 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 768486001233 ABC transporter signature motif; other site 768486001234 Walker B; other site 768486001235 D-loop; other site 768486001236 ABC transporter; Region: ABC_tran_2; pfam12848 768486001237 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 768486001238 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 768486001239 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768486001240 putative substrate translocation pore; other site 768486001241 Uncharacterized conserved protein [Function unknown]; Region: COG0398 768486001242 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 768486001243 Quinolinate synthetase A protein; Region: NadA; cl00420 768486001244 Abi-like protein; Region: Abi_2; pfam07751 768486001245 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 768486001246 Phage holin; Region: Phage_holin_5; pfam06946 768486001247 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 768486001248 active site 768486001249 catalytic triad [active] 768486001250 oxyanion hole [active] 768486001251 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 768486001252 Phage tail protein; Region: Sipho_tail; cl17486 768486001253 tape measure domain; Region: tape_meas_nterm; TIGR02675 768486001254 Bacteriophage Gp15 protein; Region: Phage_Gp15; pfam06854 768486001255 Minor capsid protein from bacteriophage; Region: Minor_capsid_3; pfam12691 768486001256 Minor capsid protein; Region: Minor_capsid_2; pfam11114 768486001257 Minor capsid protein; Region: Minor_capsid_1; pfam10665 768486001258 Head-Tail Connector Proteins gp6 and gp15, and similar proteins; Region: gp6_gp15_like; cl12049 768486001259 HeH/LEM domain; Region: HeH; pfam12949 768486001260 Phage minor structural protein GP20; Region: Phage_GP20; pfam06810 768486001261 Phage minor capsid protein 2; Region: Phage_min_cap2; pfam06152 768486001262 phage portal protein, putative, A118 family; Region: A118_put_portal; TIGR01542 768486001263 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 768486001264 potential frameshift: common BLAST hit: gi|258508120|ref|YP_003170871.1| phage-related terminase large subunit 768486001265 Uncharacterized conserved protein [Function unknown]; Region: COG5484 768486001266 Homeodomain-like domain; Region: HTH_23; pfam13384 768486001267 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 768486001268 DNA binding residues [nucleotide binding] 768486001269 Protein of unknown function (DUF1642); Region: DUF1642; pfam07852 768486001270 YopX protein; Region: YopX; pfam09643 768486001271 Protein of unknown function (DUF1064); Region: DUF1064; pfam06356 768486001272 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 768486001273 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768486001274 Walker A motif; other site 768486001275 ATP binding site [chemical binding]; other site 768486001276 Walker B motif; other site 768486001277 Helix-turn-helix domain; Region: HTH_36; pfam13730 768486001278 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 768486001279 potential frameshift: common BLAST hit: gi|28211758|ref|NP_782702.1| recT protein 768486001280 YqaJ-like viral recombinase domain; Region: YqaJ; cl09232 768486001281 YqaJ-like viral recombinase domain; Region: YqaJ; cl09232 768486001282 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 768486001283 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 768486001284 salt bridge; other site 768486001285 non-specific DNA binding site [nucleotide binding]; other site 768486001286 sequence-specific DNA binding site [nucleotide binding]; other site 768486001287 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 768486001288 non-specific DNA binding site [nucleotide binding]; other site 768486001289 salt bridge; other site 768486001290 sequence-specific DNA binding site [nucleotide binding]; other site 768486001291 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 768486001292 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 768486001293 non-specific DNA binding site [nucleotide binding]; other site 768486001294 salt bridge; other site 768486001295 sequence-specific DNA binding site [nucleotide binding]; other site 768486001296 Predicted transcriptional regulator [Transcription]; Region: COG2932 768486001297 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 768486001298 Catalytic site [active] 768486001299 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl17483 768486001300 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 768486001301 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 768486001302 Int/Topo IB signature motif; other site 768486001303 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 768486001304 core dimer interface [polypeptide binding]; other site 768486001305 peripheral dimer interface [polypeptide binding]; other site 768486001306 L10 interface [polypeptide binding]; other site 768486001307 L11 interface [polypeptide binding]; other site 768486001308 putative EF-Tu interaction site [polypeptide binding]; other site 768486001309 putative EF-G interaction site [polypeptide binding]; other site 768486001310 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 768486001311 23S rRNA interface [nucleotide binding]; other site 768486001312 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 768486001313 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 768486001314 mRNA/rRNA interface [nucleotide binding]; other site 768486001315 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 768486001316 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 768486001317 23S rRNA interface [nucleotide binding]; other site 768486001318 L7/L12 interface [polypeptide binding]; other site 768486001319 putative thiostrepton binding site; other site 768486001320 L25 interface [polypeptide binding]; other site 768486001321 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 768486001322 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 768486001323 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 768486001324 putative L-serine binding site [chemical binding]; other site 768486001325 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 768486001326 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 768486001327 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 768486001328 PGAP1-like protein; Region: PGAP1; pfam07819 768486001329 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 768486001330 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 768486001331 putative homodimer interface [polypeptide binding]; other site 768486001332 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 768486001333 heterodimer interface [polypeptide binding]; other site 768486001334 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 768486001335 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 768486001336 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 768486001337 QueT transporter; Region: QueT; pfam06177 768486001338 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 768486001339 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 768486001340 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 768486001341 AAA domain; Region: AAA_30; pfam13604 768486001342 Family description; Region: UvrD_C_2; pfam13538 768486001343 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 768486001344 catalytic core [active] 768486001345 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 768486001346 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 768486001347 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 768486001348 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768486001349 S-adenosylmethionine binding site [chemical binding]; other site 768486001350 Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142 768486001351 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 768486001352 MgtE intracellular N domain; Region: MgtE_N; pfam03448 768486001353 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 768486001354 Divalent cation transporter; Region: MgtE; pfam01769 768486001355 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 768486001356 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 768486001357 active site 768486001358 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 768486001359 ATP-NAD kinase; Region: NAD_kinase; pfam01513 768486001360 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 768486001361 synthetase active site [active] 768486001362 NTP binding site [chemical binding]; other site 768486001363 metal binding site [ion binding]; metal-binding site 768486001364 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 768486001365 putative active site [active] 768486001366 putative metal binding residues [ion binding]; other site 768486001367 signature motif; other site 768486001368 putative triphosphate binding site [ion binding]; other site 768486001369 Thioredoxin; Region: Thioredoxin_5; pfam13743 768486001370 intracellular protease, PfpI family; Region: PfpI; TIGR01382 768486001371 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 768486001372 proposed catalytic triad [active] 768486001373 conserved cys residue [active] 768486001374 prephenate dehydratase; Provisional; Region: PRK11898 768486001375 Prephenate dehydratase; Region: PDT; pfam00800 768486001376 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 768486001377 putative L-Phe binding site [chemical binding]; other site 768486001378 shikimate kinase; Reviewed; Region: aroK; PRK00131 768486001379 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 768486001380 ADP binding site [chemical binding]; other site 768486001381 magnesium binding site [ion binding]; other site 768486001382 putative shikimate binding site; other site 768486001383 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 768486001384 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 768486001385 hinge; other site 768486001386 active site 768486001387 potential frameshift: common BLAST hit: gi|389868773|ref|YP_006376196.1| prephenate dehydrogenase 768486001388 prephenate dehydrogenase; Validated; Region: PRK06545 768486001389 prephenate dehydrogenase; Validated; Region: PRK08507 768486001390 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 768486001391 prephenate dehydrogenase; Validated; Region: PRK08507 768486001392 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 768486001393 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 768486001394 Tetramer interface [polypeptide binding]; other site 768486001395 active site 768486001396 FMN-binding site [chemical binding]; other site 768486001397 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 768486001398 active site 768486001399 dimer interface [polypeptide binding]; other site 768486001400 metal binding site [ion binding]; metal-binding site 768486001401 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 768486001402 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 768486001403 Uncharacterized conserved protein [Function unknown]; Region: COG2461 768486001404 Family of unknown function (DUF438); Region: DUF438; pfam04282 768486001405 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 768486001406 Domain of unknown function (DUF1858); Region: DUF1858; pfam08984 768486001407 potential frameshift: common BLAST hit: gi|190606548|ref|YP_001974833.1| putative DNA-directed DNA polymerase 768486001408 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 768486001409 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768486001410 putative substrate translocation pore; other site 768486001411 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 768486001412 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 768486001413 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768486001414 putative substrate translocation pore; other site 768486001415 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 768486001416 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 768486001417 Helix-turn-helix domain; Region: HTH_18; pfam12833 768486001418 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768486001419 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 768486001420 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 768486001421 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 768486001422 PemK-like protein; Region: PemK; pfam02452 768486001423 aromatic amino acid aminotransferase; Validated; Region: PRK07309 768486001424 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 768486001425 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768486001426 homodimer interface [polypeptide binding]; other site 768486001427 catalytic residue [active] 768486001428 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 768486001429 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 768486001430 metal binding site [ion binding]; metal-binding site 768486001431 dimer interface [polypeptide binding]; other site 768486001432 aspartate kinase; Reviewed; Region: PRK09034 768486001433 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 768486001434 nucleotide binding site [chemical binding]; other site 768486001435 substrate binding site [chemical binding]; other site 768486001436 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 768486001437 allosteric regulatory residue; other site 768486001438 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 768486001439 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 768486001440 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 768486001441 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 768486001442 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 768486001443 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 768486001444 putative trimer interface [polypeptide binding]; other site 768486001445 putative CoA binding site [chemical binding]; other site 768486001446 potential frameshift: common BLAST hit: gi|389867662|ref|YP_006375085.1| dihydrodipicolinate reductase 768486001447 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 768486001448 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 768486001449 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 768486001450 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 768486001451 dihydrodipicolinate synthase; Region: dapA; TIGR00674 768486001452 dimer interface [polypeptide binding]; other site 768486001453 active site 768486001454 catalytic residue [active] 768486001455 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 768486001456 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 768486001457 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 768486001458 diaminopimelate decarboxylase; Region: lysA; TIGR01048 768486001459 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 768486001460 active site 768486001461 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 768486001462 substrate binding site [chemical binding]; other site 768486001463 catalytic residues [active] 768486001464 dimer interface [polypeptide binding]; other site 768486001465 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 768486001466 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 768486001467 potential frameshift: common BLAST hit: gi|389868574|ref|YP_006375997.1| sortase 768486001468 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098 768486001469 catalytic site [active] 768486001470 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098 768486001471 active site 768486001472 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 768486001473 Cna protein B-type domain; Region: Cna_B; pfam05738 768486001474 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 768486001475 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 768486001476 Cna protein B-type domain; Region: Cna_B; pfam05738 768486001477 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 768486001478 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 768486001479 metal ion-dependent adhesion site (MIDAS); other site 768486001480 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 768486001481 domain interaction interfaces [polypeptide binding]; other site 768486001482 Cna protein B-type domain; Region: Cna_B; pfam05738 768486001483 Cna protein B-type domain; Region: Cna_B; pfam05738 768486001484 Mga helix-turn-helix domain; Region: Mga; pfam05043 768486001485 elongation factor P; Validated; Region: PRK00529 768486001486 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 768486001487 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 768486001488 RNA binding site [nucleotide binding]; other site 768486001489 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 768486001490 RNA binding site [nucleotide binding]; other site 768486001491 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 768486001492 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 768486001493 dimer interface [polypeptide binding]; other site 768486001494 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768486001495 catalytic residue [active] 768486001496 cystathionine gamma-synthase/cystathionine beta-lyase; Validated; Region: PRK06176 768486001497 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 768486001498 homodimer interface [polypeptide binding]; other site 768486001499 substrate-cofactor binding pocket; other site 768486001500 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768486001501 catalytic residue [active] 768486001502 S-ribosylhomocysteinase; Provisional; Region: PRK02260 768486001503 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 768486001504 catalytic residues [active] 768486001505 dimer interface [polypeptide binding]; other site 768486001506 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 768486001507 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 768486001508 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 768486001509 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 768486001510 ArsC family; Region: ArsC; pfam03960 768486001511 putative catalytic residues [active] 768486001512 thiol/disulfide switch; other site 768486001513 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 768486001514 ArsC family; Region: ArsC; pfam03960 768486001515 putative catalytic residues [active] 768486001516 thiol/disulfide switch; other site 768486001517 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 768486001518 Part of AAA domain; Region: AAA_19; pfam13245 768486001519 Family description; Region: UvrD_C_2; pfam13538 768486001520 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 768486001521 DNA polymerase type-B family catalytic domain. DNA-directed DNA polymerases elongate DNA by adding nucleotide triphosphate (dNTP) residues to the 5'-end of the growing chain of DNA. DNA-directed DNA polymerases are multifunctional with both...; Region: POLBc; cl10023 768486001522 Accessory gene regulator B; Region: AgrB; pfam04647 768486001523 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 768486001524 potential frameshift: common BLAST hit: gi|389867643|ref|YP_006375066.1| accessory gene regulator protein A 768486001525 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 768486001526 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768486001527 active site 768486001528 phosphorylation site [posttranslational modification] 768486001529 intermolecular recognition site; other site 768486001530 dimerization interface [polypeptide binding]; other site 768486001531 LytTr DNA-binding domain; Region: LytTR; cl04498 768486001532 LytTr DNA-binding domain; Region: LytTR; pfam04397 768486001533 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 768486001534 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 768486001535 metal binding site [ion binding]; metal-binding site 768486001536 YodA lipocalin-like domain; Region: YodA; pfam09223 768486001537 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 768486001538 Domain of unknown function DUF20; Region: UPF0118; pfam01594 768486001539 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 768486001540 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 768486001541 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 768486001542 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 768486001543 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 768486001544 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 768486001545 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 768486001546 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 768486001547 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 768486001548 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 768486001549 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 768486001550 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 768486001551 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 768486001552 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 768486001553 Ca binding site [ion binding]; other site 768486001554 active site 768486001555 catalytic site [active] 768486001556 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 768486001557 FtsX-like permease family; Region: FtsX; pfam02687 768486001558 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 768486001559 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 768486001560 FtsX-like permease family; Region: FtsX; pfam02687 768486001561 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 768486001562 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 768486001563 Walker A/P-loop; other site 768486001564 ATP binding site [chemical binding]; other site 768486001565 Q-loop/lid; other site 768486001566 ABC transporter signature motif; other site 768486001567 Walker B; other site 768486001568 D-loop; other site 768486001569 H-loop/switch region; other site 768486001570 Isochorismatase family; Region: Isochorismatase; pfam00857 768486001571 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 768486001572 catalytic triad [active] 768486001573 conserved cis-peptide bond; other site 768486001574 potential frameshift: common BLAST hit: gi|29377426|ref|NP_816580.1| LacI family sugar-binding transcriptional regulator 768486001575 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 768486001576 NlpC/P60 family; Region: NLPC_P60; pfam00877 768486001577 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 768486001578 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 768486001579 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 768486001580 Walker A/P-loop; other site 768486001581 ATP binding site [chemical binding]; other site 768486001582 Q-loop/lid; other site 768486001583 ABC transporter signature motif; other site 768486001584 Walker B; other site 768486001585 D-loop; other site 768486001586 H-loop/switch region; other site 768486001587 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 768486001588 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 768486001589 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_2; cd03402 768486001590 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 768486001591 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 768486001592 Protein of unknown function (DUF1700); Region: DUF1700; pfam08006 768486001593 Predicted transcriptional regulators [Transcription]; Region: COG1695 768486001594 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 768486001595 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 768486001596 TRAM1-like protein; Region: TRAM1; pfam08390 768486001597 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 768486001598 dimerization interface [polypeptide binding]; other site 768486001599 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768486001600 dimer interface [polypeptide binding]; other site 768486001601 phosphorylation site [posttranslational modification] 768486001602 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768486001603 ATP binding site [chemical binding]; other site 768486001604 Mg2+ binding site [ion binding]; other site 768486001605 G-X-G motif; other site 768486001606 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 768486001607 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768486001608 active site 768486001609 phosphorylation site [posttranslational modification] 768486001610 intermolecular recognition site; other site 768486001611 dimerization interface [polypeptide binding]; other site 768486001612 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 768486001613 DNA binding site [nucleotide binding] 768486001614 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 768486001615 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 768486001616 Walker A/P-loop; other site 768486001617 ATP binding site [chemical binding]; other site 768486001618 Q-loop/lid; other site 768486001619 ABC transporter signature motif; other site 768486001620 Walker B; other site 768486001621 D-loop; other site 768486001622 H-loop/switch region; other site 768486001623 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 768486001624 FtsX-like permease family; Region: FtsX; pfam02687 768486001625 RNA polymerase sigma-70 factor, TIGR02954 family; Region: Sig70_famx3 768486001626 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 768486001627 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 768486001628 DNA binding residues [nucleotide binding] 768486001629 Domain of unknown function (DUF1905); Region: DUF1905; pfam08922 768486001630 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768486001631 Major Facilitator Superfamily; Region: MFS_1; pfam07690 768486001632 putative substrate translocation pore; other site 768486001633 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768486001634 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 768486001635 DNA binding residues [nucleotide binding] 768486001636 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 768486001637 putative dimer interface [polypeptide binding]; other site 768486001638 Predicted transcriptional regulators [Transcription]; Region: COG1695 768486001639 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 768486001640 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 768486001641 Phenolic acid decarboxylase (PAD); Region: PA_decarbox; cl01382 768486001642 UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase; Region: Arch_glmU; TIGR03992 768486001643 Streptococcus agalactiae RgfB, part of a putative two component signal transduction system, and related proteins; Region: RgfB-like; cd09079 768486001644 putative catalytic site [active] 768486001645 putative metal binding site [ion binding]; other site 768486001646 putative phosphate binding site [ion binding]; other site 768486001647 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 768486001648 PTS system, IIBC component; Region: PTS-II-BC-unk1; TIGR02003 768486001649 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 768486001650 active site turn [active] 768486001651 phosphorylation site [posttranslational modification] 768486001652 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 768486001653 HPr interaction site; other site 768486001654 glycerol kinase (GK) interaction site [polypeptide binding]; other site 768486001655 active site 768486001656 phosphorylation site [posttranslational modification] 768486001657 maltose phosphorylase; Provisional; Region: PRK13807 768486001658 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 768486001659 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 768486001660 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 768486001661 beta-phosphoglucomutase; Region: bPGM; TIGR01990 768486001662 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 768486001663 motif II; other site 768486001664 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 768486001665 active site 768486001666 catalytic residues [active] 768486001667 Transcriptional regulators [Transcription]; Region: PurR; COG1609 768486001668 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 768486001669 DNA binding site [nucleotide binding] 768486001670 domain linker motif; other site 768486001671 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 768486001672 putative dimerization interface [polypeptide binding]; other site 768486001673 putative ligand binding site [chemical binding]; other site 768486001674 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 768486001675 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 768486001676 tyrosine decarboxylase, Enterococcus type; Region: tyr_de_CO2_Ent; TIGR03811 768486001677 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 768486001678 catalytic residue [active] 768486001679 tyrosyl-tRNA synthetase; Provisional; Region: PRK13354 768486001680 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 768486001681 active site 768486001682 HIGH motif; other site 768486001683 dimer interface [polypeptide binding]; other site 768486001684 KMSKS motif; other site 768486001685 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 768486001686 RNA binding surface [nucleotide binding]; other site 768486001687 Glucose-6-phosphate 1-dehydrogenase (EC 1.1.1.49); Region: G6PD_bact; pfam10786 768486001688 dihydroxyacetone kinase, phosphoprotein-dependent, L subunit; Region: dha_L_ycgS; TIGR02365 768486001689 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 768486001690 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 768486001691 dihydroxyacetone kinase, phosphotransfer subunit; Region: dha_pts; TIGR02364 768486001692 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 768486001693 dipeptidase PepV; Reviewed; Region: PRK07318 768486001694 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 768486001695 active site 768486001696 metal binding site [ion binding]; metal-binding site 768486001697 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 768486001698 putative substrate binding site [chemical binding]; other site 768486001699 putative ATP binding site [chemical binding]; other site 768486001700 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 768486001701 active site 768486001702 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 768486001703 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 768486001704 phospholipase D; Region: PLN02866 768486001705 multiple promoter invertase; Provisional; Region: mpi; PRK13413 768486001706 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 768486001707 catalytic residues [active] 768486001708 catalytic nucleophile [active] 768486001709 Presynaptic Site I dimer interface [polypeptide binding]; other site 768486001710 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 768486001711 Synaptic Flat tetramer interface [polypeptide binding]; other site 768486001712 Synaptic Site I dimer interface [polypeptide binding]; other site 768486001713 DNA binding site [nucleotide binding] 768486001714 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 768486001715 active site 768486001716 DNA binding site [nucleotide binding] 768486001717 Int/Topo IB signature motif; other site 768486001718 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 768486001719 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 768486001720 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 768486001721 Int/Topo IB signature motif; other site 768486001722 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 768486001723 23S rRNA binding site [nucleotide binding]; other site 768486001724 L21 binding site [polypeptide binding]; other site 768486001725 L13 binding site [polypeptide binding]; other site 768486001726 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 768486001727 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 768486001728 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 768486001729 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 768486001730 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 768486001731 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 768486001732 Cl binding site [ion binding]; other site 768486001733 oligomer interface [polypeptide binding]; other site 768486001734 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 768486001735 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 768486001736 Substrate-binding site [chemical binding]; other site 768486001737 Substrate specificity [chemical binding]; other site 768486001738 mevalonate kinase; Region: mevalon_kin; TIGR00549 768486001739 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 768486001740 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 768486001741 diphosphomevalonate decarboxylase; Region: mevDPdecarb; TIGR01240 768486001742 diphosphomevalonate decarboxylase; Region: PLN02407 768486001743 phosphomevalonate kinase, ERG8-type, Gram-positive branch; Region: Pmev_kin_Gr_pos; TIGR01220 768486001744 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 768486001745 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 768486001746 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 768486001747 homotetramer interface [polypeptide binding]; other site 768486001748 FMN binding site [chemical binding]; other site 768486001749 homodimer contacts [polypeptide binding]; other site 768486001750 putative active site [active] 768486001751 putative substrate binding site [chemical binding]; other site 768486001752 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 768486001753 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 768486001754 putative catalytic cysteine [active] 768486001755 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 768486001756 putative active site [active] 768486001757 metal binding site [ion binding]; metal-binding site 768486001758 Preprotein translocase subunit; Region: YajC; cl00806 768486001759 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 768486001760 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 768486001761 Protein of unknown function (DUF975); Region: DUF975; cl10504 768486001762 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 768486001763 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 768486001764 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 768486001765 UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057 768486001766 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 768486001767 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 768486001768 potential frameshift: common BLAST hit: gi|325970217|ref|YP_004246408.1| NAD-dependent epimerase/dehydratase 768486001769 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 768486001770 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 768486001771 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 768486001772 active site 768486001773 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 768486001774 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 768486001775 putative ADP-binding pocket [chemical binding]; other site 768486001776 Bacterial sugar transferase; Region: Bac_transf; pfam02397 768486001777 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 768486001778 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 768486001779 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098 768486001780 active site 768486001781 catalytic site [active] 768486001782 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 768486001783 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 768486001784 Chain length determinant protein; Region: Wzz; cl15801 768486001785 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 768486001786 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 768486001787 choice-of-anchor C domain; Region: choice_anch_C; TIGR04362 768486001788 Viral enhancin protein; Region: Enhancin; pfam03272 768486001789 Peptidase M60-like family; Region: M60-like; pfam13402 768486001790 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 768486001791 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 768486001792 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 768486001793 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 768486001794 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 768486001795 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 768486001796 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 768486001797 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 768486001798 Amino acid permease; Region: AA_permease_2; pfam13520 768486001799 Predicted membrane protein [Function unknown]; Region: COG1511 768486001800 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 768486001801 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 768486001802 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 768486001803 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 768486001804 putative NAD(P) binding site [chemical binding]; other site 768486001805 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 768486001806 PemK-like protein; Region: PemK; pfam02452 768486001807 alanine racemase; Reviewed; Region: alr; PRK00053 768486001808 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 768486001809 active site 768486001810 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 768486001811 dimer interface [polypeptide binding]; other site 768486001812 substrate binding site [chemical binding]; other site 768486001813 catalytic residues [active] 768486001814 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 768486001815 DEAD-like helicases superfamily; Region: DEXDc; smart00487 768486001816 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 768486001817 ATP binding site [chemical binding]; other site 768486001818 Mg++ binding site [ion binding]; other site 768486001819 motif III; other site 768486001820 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 768486001821 nucleotide binding region [chemical binding]; other site 768486001822 ATP-binding site [chemical binding]; other site 768486001823 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 768486001824 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 768486001825 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 768486001826 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 768486001827 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 768486001828 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 768486001829 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 768486001830 Protein of unknown function (DUF2512); Region: DUF2512; pfam10710 768486001831 Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; cl00727 768486001832 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768486001833 Coenzyme A binding pocket [chemical binding]; other site 768486001834 Uncharacterized conserved protein [Function unknown]; Region: COG0398 768486001835 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 768486001836 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 768486001837 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 768486001838 Sugar specificity; other site 768486001839 Pyrimidine base specificity; other site 768486001840 ATP-binding site [chemical binding]; other site 768486001841 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 768486001842 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 768486001843 motif II; other site 768486001844 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 768486001845 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 768486001846 active site 768486001847 uracil binding [chemical binding]; other site 768486001848 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 768486001849 ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731 768486001850 5S rRNA interface [nucleotide binding]; other site 768486001851 CTC domain interface [polypeptide binding]; other site 768486001852 L16 interface [polypeptide binding]; other site 768486001853 Staphylococcal protein of unknown function (DUF960); Region: DUF960; pfam06124 768486001854 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 768486001855 putative efflux protein, MATE family; Region: matE; TIGR00797 768486001856 Heat induced stress protein YflT; Region: YflT; pfam11181 768486001857 Domain of unknown function (DUF2382); Region: DUF2382; pfam09557 768486001858 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 768486001859 Domain of unknown function DUF21; Region: DUF21; pfam01595 768486001860 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 768486001861 Transporter associated domain; Region: CorC_HlyC; smart01091 768486001862 K+ potassium transporter; Region: K_trans; cl15781 768486001863 Predicted membrane protein [Function unknown]; Region: COG2261 768486001864 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 768486001865 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 768486001866 RNase E interface [polypeptide binding]; other site 768486001867 trimer interface [polypeptide binding]; other site 768486001868 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 768486001869 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 768486001870 RNase E interface [polypeptide binding]; other site 768486001871 trimer interface [polypeptide binding]; other site 768486001872 active site 768486001873 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 768486001874 putative nucleic acid binding region [nucleotide binding]; other site 768486001875 G-X-X-G motif; other site 768486001876 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 768486001877 RNA binding site [nucleotide binding]; other site 768486001878 domain interface; other site 768486001879 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 768486001880 16S/18S rRNA binding site [nucleotide binding]; other site 768486001881 S13e-L30e interaction site [polypeptide binding]; other site 768486001882 25S rRNA binding site [nucleotide binding]; other site 768486001883 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 768486001884 active site 768486001885 catalytic residues [active] 768486001886 metal binding site [ion binding]; metal-binding site 768486001887 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 768486001888 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 768486001889 HTH domain; Region: HTH_11; pfam08279 768486001890 3H domain; Region: 3H; pfam02829 768486001891 maltose O-acetyltransferase; Provisional; Region: PRK10092 768486001892 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 768486001893 active site 768486001894 substrate binding site [chemical binding]; other site 768486001895 trimer interface [polypeptide binding]; other site 768486001896 CoA binding site [chemical binding]; other site 768486001897 hypothetical protein; Provisional; Region: PRK07248 768486001898 NAD-dependent deacetylase; Provisional; Region: PRK00481 768486001899 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 768486001900 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 768486001901 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 768486001902 substrate binding pocket [chemical binding]; other site 768486001903 membrane-bound complex binding site; other site 768486001904 hinge residues; other site 768486001905 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 768486001906 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768486001907 dimer interface [polypeptide binding]; other site 768486001908 conserved gate region; other site 768486001909 putative PBP binding loops; other site 768486001910 ABC-ATPase subunit interface; other site 768486001911 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 768486001912 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 768486001913 Walker A/P-loop; other site 768486001914 ATP binding site [chemical binding]; other site 768486001915 Q-loop/lid; other site 768486001916 ABC transporter signature motif; other site 768486001917 Walker B; other site 768486001918 D-loop; other site 768486001919 H-loop/switch region; other site 768486001920 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 768486001921 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 768486001922 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 768486001923 Low molecular weight phosphatase family; Region: LMWPc; cd00115 768486001924 active site 768486001925 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 768486001926 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 768486001927 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 768486001928 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768486001929 Walker A motif; other site 768486001930 ATP binding site [chemical binding]; other site 768486001931 Walker B motif; other site 768486001932 arginine finger; other site 768486001933 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 768486001934 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 768486001935 RuvA N terminal domain; Region: RuvA_N; pfam01330 768486001936 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 768486001937 methionine sulfoxide reductase B; Provisional; Region: PRK00222 768486001938 SelR domain; Region: SelR; pfam01641 768486001939 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 768486001940 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 768486001941 DNA-binding site [nucleotide binding]; DNA binding site 768486001942 UTRA domain; Region: UTRA; pfam07702 768486001943 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 768486001944 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 768486001945 active site turn [active] 768486001946 phosphorylation site [posttranslational modification] 768486001947 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 768486001948 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 768486001949 HPr interaction site; other site 768486001950 glycerol kinase (GK) interaction site [polypeptide binding]; other site 768486001951 active site 768486001952 phosphorylation site [posttranslational modification] 768486001953 Maf-like protein; Region: Maf; pfam02545 768486001954 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 768486001955 active site 768486001956 dimer interface [polypeptide binding]; other site 768486001957 DNA mismatch repair enzyme (predicted ATPase) [DNA replication, recombination, and repair]; Region: MutL; COG0323 768486001958 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768486001959 ATP binding site [chemical binding]; other site 768486001960 Mg2+ binding site [ion binding]; other site 768486001961 G-X-G motif; other site 768486001962 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 768486001963 ATP binding site [chemical binding]; other site 768486001964 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 768486001965 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 768486001966 MutS domain I; Region: MutS_I; pfam01624 768486001967 MutS domain II; Region: MutS_II; pfam05188 768486001968 MutS domain III; Region: MutS_III; pfam05192 768486001969 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 768486001970 Walker A/P-loop; other site 768486001971 ATP binding site [chemical binding]; other site 768486001972 Q-loop/lid; other site 768486001973 ABC transporter signature motif; other site 768486001974 Walker B; other site 768486001975 D-loop; other site 768486001976 H-loop/switch region; other site 768486001977 Protein of unknown function (DUF964); Region: DUF964; cl01483 768486001978 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 768486001979 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 768486001980 putative active site [active] 768486001981 metal binding site [ion binding]; metal-binding site 768486001982 homodimer binding site [polypeptide binding]; other site 768486001983 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 768486001984 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 768486001985 active site 768486001986 motif I; other site 768486001987 motif II; other site 768486001988 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 768486001989 potential frameshift: common BLAST hit: gi|389867314|ref|YP_006374737.1| DNA alkylation repair protein 768486001990 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 768486001991 A new structural DNA glycosylase; Region: AlkD_like; cl11434 768486001992 active site 768486001993 A new structural DNA glycosylase; Region: AlkD_like; cl11434 768486001994 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 768486001995 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 768486001996 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 768486001997 RNA binding surface [nucleotide binding]; other site 768486001998 BioY family; Region: BioY; pfam02632 768486001999 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 768486002000 QueT transporter; Region: QueT; pfam06177 768486002001 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK06550 768486002002 classical (c) SDRs; Region: SDR_c; cd05233 768486002003 NAD(P) binding site [chemical binding]; other site 768486002004 active site 768486002005 Protein of unknown function (DUF2829); Region: DUF2829; pfam11195 768486002006 Mga helix-turn-helix domain; Region: Mga; pfam05043 768486002007 LrgB-like family; Region: LrgB; pfam04172 768486002008 LrgA family; Region: LrgA; pfam03788 768486002009 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 768486002010 amphipathic channel; other site 768486002011 Asn-Pro-Ala signature motifs; other site 768486002012 putative phosphoesterase; Region: acc_ester; TIGR03729 768486002013 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4918 768486002014 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 768486002015 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 768486002016 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 768486002017 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 768486002018 putative ligand binding residues [chemical binding]; other site 768486002019 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 768486002020 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 768486002021 Walker A/P-loop; other site 768486002022 ATP binding site [chemical binding]; other site 768486002023 Q-loop/lid; other site 768486002024 ABC transporter signature motif; other site 768486002025 Walker B; other site 768486002026 D-loop; other site 768486002027 H-loop/switch region; other site 768486002028 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 768486002029 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 768486002030 ABC-ATPase subunit interface; other site 768486002031 dimer interface [polypeptide binding]; other site 768486002032 putative PBP binding regions; other site 768486002033 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 768486002034 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 768486002035 ABC-ATPase subunit interface; other site 768486002036 dimer interface [polypeptide binding]; other site 768486002037 putative PBP binding regions; other site 768486002038 Protein of unknown function (DUF1694); Region: DUF1694; pfam07997 768486002039 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 768486002040 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 768486002041 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 768486002042 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 768486002043 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 768486002044 bifunctional glutamate--cysteine ligase/glutathione synthetase; Provisional; Region: PRK02471 768486002045 Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352 768486002046 ATP-grasp domain; Region: ATP-grasp_4; cl17255 768486002047 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 768486002048 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 768486002049 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 768486002050 P loop; other site 768486002051 GTP binding site [chemical binding]; other site 768486002052 sugar phosphate phosphatase; Provisional; Region: PRK10513 768486002053 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 768486002054 active site 768486002055 motif I; other site 768486002056 motif II; other site 768486002057 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 768486002058 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 768486002059 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 768486002060 Walker A/P-loop; other site 768486002061 ATP binding site [chemical binding]; other site 768486002062 Q-loop/lid; other site 768486002063 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 768486002064 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 768486002065 ABC transporter signature motif; other site 768486002066 Walker B; other site 768486002067 D-loop; other site 768486002068 H-loop/switch region; other site 768486002069 ribonuclease III; Reviewed; Region: rnc; PRK00102 768486002070 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 768486002071 dimerization interface [polypeptide binding]; other site 768486002072 active site 768486002073 metal binding site [ion binding]; metal-binding site 768486002074 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 768486002075 dsRNA binding site [nucleotide binding]; other site 768486002076 The substrate binding component of an ABC-type lactococcal OppA-like transport system contains; Region: PBP2_Lactococcal_OppA_like; cd08510 768486002077 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 768486002078 peptide binding site [polypeptide binding]; other site 768486002079 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 768486002080 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768486002081 dimer interface [polypeptide binding]; other site 768486002082 conserved gate region; other site 768486002083 putative PBP binding loops; other site 768486002084 ABC-ATPase subunit interface; other site 768486002085 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 768486002086 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768486002087 dimer interface [polypeptide binding]; other site 768486002088 conserved gate region; other site 768486002089 putative PBP binding loops; other site 768486002090 ABC-ATPase subunit interface; other site 768486002091 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 768486002092 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 768486002093 Walker A/P-loop; other site 768486002094 ATP binding site [chemical binding]; other site 768486002095 Q-loop/lid; other site 768486002096 ABC transporter signature motif; other site 768486002097 Walker B; other site 768486002098 D-loop; other site 768486002099 H-loop/switch region; other site 768486002100 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 768486002101 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 768486002102 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 768486002103 Walker A/P-loop; other site 768486002104 ATP binding site [chemical binding]; other site 768486002105 Q-loop/lid; other site 768486002106 ABC transporter signature motif; other site 768486002107 Walker B; other site 768486002108 D-loop; other site 768486002109 H-loop/switch region; other site 768486002110 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 768486002111 acyl carrier protein; Provisional; Region: acpP; PRK00982 768486002112 putative phosphate acyltransferase; Provisional; Region: PRK05331 768486002113 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 768486002114 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 768486002115 generic binding surface II; other site 768486002116 ssDNA binding site; other site 768486002117 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 768486002118 ATP binding site [chemical binding]; other site 768486002119 putative Mg++ binding site [ion binding]; other site 768486002120 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 768486002121 nucleotide binding region [chemical binding]; other site 768486002122 ATP-binding site [chemical binding]; other site 768486002123 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 768486002124 DAK2 domain; Region: Dak2; pfam02734 768486002125 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 768486002126 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 768486002127 potential frameshift: common BLAST hit: gi|332685566|ref|YP_004455340.1| ABC transporter permease 768486002128 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 768486002129 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 768486002130 dimerization interface 3.5A [polypeptide binding]; other site 768486002131 active site 768486002132 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 768486002133 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13634 768486002134 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 768486002135 Walker A/P-loop; other site 768486002136 ATP binding site [chemical binding]; other site 768486002137 Q-loop/lid; other site 768486002138 ABC transporter signature motif; other site 768486002139 Walker B; other site 768486002140 D-loop; other site 768486002141 H-loop/switch region; other site 768486002142 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635 768486002143 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 768486002144 Walker A/P-loop; other site 768486002145 ATP binding site [chemical binding]; other site 768486002146 Q-loop/lid; other site 768486002147 ABC transporter signature motif; other site 768486002148 Walker B; other site 768486002149 D-loop; other site 768486002150 H-loop/switch region; other site 768486002151 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 768486002152 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 768486002153 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 768486002154 alphaNTD homodimer interface [polypeptide binding]; other site 768486002155 alphaNTD - beta interaction site [polypeptide binding]; other site 768486002156 alphaNTD - beta' interaction site [polypeptide binding]; other site 768486002157 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 768486002158 potential frameshift: common BLAST hit: gi|29374877|ref|NP_814030.1| DNA-directed RNA polymerase subunit alpha 768486002159 30S ribosomal protein S11; Validated; Region: PRK05309 768486002160 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 768486002161 30S ribosomal protein S13; Region: bact_S13; TIGR03631 768486002162 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 768486002163 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 768486002164 rRNA binding site [nucleotide binding]; other site 768486002165 predicted 30S ribosome binding site; other site 768486002166 adenylate kinase; Reviewed; Region: adk; PRK00279 768486002167 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 768486002168 AMP-binding site [chemical binding]; other site 768486002169 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 768486002170 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 768486002171 SecY translocase; Region: SecY; pfam00344 768486002172 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 768486002173 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 768486002174 23S rRNA binding site [nucleotide binding]; other site 768486002175 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 768486002176 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 768486002177 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 768486002178 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 768486002179 5S rRNA interface [nucleotide binding]; other site 768486002180 L27 interface [polypeptide binding]; other site 768486002181 23S rRNA interface [nucleotide binding]; other site 768486002182 L5 interface [polypeptide binding]; other site 768486002183 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 768486002184 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 768486002185 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 768486002186 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 768486002187 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 768486002188 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 768486002189 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 768486002190 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 768486002191 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 768486002192 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 768486002193 RNA binding site [nucleotide binding]; other site 768486002194 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 768486002195 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 768486002196 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 768486002197 23S rRNA interface [nucleotide binding]; other site 768486002198 putative translocon interaction site; other site 768486002199 signal recognition particle (SRP54) interaction site; other site 768486002200 L23 interface [polypeptide binding]; other site 768486002201 trigger factor interaction site; other site 768486002202 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 768486002203 23S rRNA interface [nucleotide binding]; other site 768486002204 5S rRNA interface [nucleotide binding]; other site 768486002205 putative antibiotic binding site [chemical binding]; other site 768486002206 L25 interface [polypeptide binding]; other site 768486002207 L27 interface [polypeptide binding]; other site 768486002208 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 768486002209 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 768486002210 G-X-X-G motif; other site 768486002211 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 768486002212 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 768486002213 putative translocon binding site; other site 768486002214 protein-rRNA interface [nucleotide binding]; other site 768486002215 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 768486002216 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 768486002217 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 768486002218 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 768486002219 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 768486002220 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 768486002221 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 768486002222 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 768486002223 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 768486002224 intersubunit interface [polypeptide binding]; other site 768486002225 active site 768486002226 zinc binding site [ion binding]; other site 768486002227 Na+ binding site [ion binding]; other site 768486002228 potential frameshift: common BLAST hit: gi|116873569|ref|YP_850350.1| fructose-bisphosphate aldolase 768486002229 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 768486002230 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 768486002231 active site 768486002232 P-loop; other site 768486002233 phosphorylation site [posttranslational modification] 768486002234 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 768486002235 active site 768486002236 phosphorylation site [posttranslational modification] 768486002237 potential frameshift: common BLAST hit: gi|289435488|ref|YP_003465360.1| DNA-binding/PRD domain protein 768486002238 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 768486002239 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 768486002240 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 768486002241 active site turn [active] 768486002242 phosphorylation site [posttranslational modification] 768486002243 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 768486002244 HPr interaction site; other site 768486002245 glycerol kinase (GK) interaction site [polypeptide binding]; other site 768486002246 active site 768486002247 phosphorylation site [posttranslational modification] 768486002248 transcriptional antiterminator BglG; Provisional; Region: PRK09772 768486002249 CAT RNA binding domain; Region: CAT_RBD; smart01061 768486002250 PRD domain; Region: PRD; pfam00874 768486002251 PRD domain; Region: PRD; pfam00874 768486002252 elongation factor Tu; Reviewed; Region: PRK00049 768486002253 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 768486002254 G1 box; other site 768486002255 GEF interaction site [polypeptide binding]; other site 768486002256 GTP/Mg2+ binding site [chemical binding]; other site 768486002257 Switch I region; other site 768486002258 G2 box; other site 768486002259 G3 box; other site 768486002260 Switch II region; other site 768486002261 G4 box; other site 768486002262 G5 box; other site 768486002263 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 768486002264 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 768486002265 Antibiotic Binding Site [chemical binding]; other site 768486002266 elongation factor G; Reviewed; Region: PRK00007 768486002267 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 768486002268 G1 box; other site 768486002269 putative GEF interaction site [polypeptide binding]; other site 768486002270 GTP/Mg2+ binding site [chemical binding]; other site 768486002271 Switch I region; other site 768486002272 G2 box; other site 768486002273 G3 box; other site 768486002274 Switch II region; other site 768486002275 G4 box; other site 768486002276 G5 box; other site 768486002277 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 768486002278 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 768486002279 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 768486002280 30S ribosomal protein S7; Validated; Region: PRK05302 768486002281 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 768486002282 S17 interaction site [polypeptide binding]; other site 768486002283 S8 interaction site; other site 768486002284 16S rRNA interaction site [nucleotide binding]; other site 768486002285 streptomycin interaction site [chemical binding]; other site 768486002286 23S rRNA interaction site [nucleotide binding]; other site 768486002287 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 768486002288 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 768486002289 tetramer (dimer of dimers) interface [polypeptide binding]; other site 768486002290 active site 768486002291 dimer interface [polypeptide binding]; other site 768486002292 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 768486002293 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 768486002294 catalytic residues [active] 768486002295 catalytic nucleophile [active] 768486002296 Presynaptic Site I dimer interface [polypeptide binding]; other site 768486002297 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 768486002298 Synaptic Flat tetramer interface [polypeptide binding]; other site 768486002299 Synaptic Site I dimer interface [polypeptide binding]; other site 768486002300 DNA binding site [nucleotide binding] 768486002301 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 768486002302 catalytic core [active] 768486002303 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 768486002304 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 768486002305 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 768486002306 purine nucleoside phosphorylase; Provisional; Region: PRK08202 768486002307 phosphopentomutase; Provisional; Region: PRK05362 768486002308 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 768486002309 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 768486002310 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 768486002311 TM-ABC transporter signature motif; other site 768486002312 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 768486002313 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 768486002314 TM-ABC transporter signature motif; other site 768486002315 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 768486002316 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 768486002317 Walker A/P-loop; other site 768486002318 ATP binding site [chemical binding]; other site 768486002319 Q-loop/lid; other site 768486002320 ABC transporter signature motif; other site 768486002321 Walker B; other site 768486002322 D-loop; other site 768486002323 H-loop/switch region; other site 768486002324 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 768486002325 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 768486002326 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 768486002327 ligand binding site [chemical binding]; other site 768486002328 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 768486002329 active site 768486002330 catalytic motif [active] 768486002331 Zn binding site [ion binding]; other site 768486002332 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 768486002333 intersubunit interface [polypeptide binding]; other site 768486002334 active site 768486002335 catalytic residue [active] 768486002336 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 768486002337 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 768486002338 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 768486002339 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 768486002340 Transcriptional regulators [Transcription]; Region: PurR; COG1609 768486002341 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 768486002342 DNA binding site [nucleotide binding] 768486002343 domain linker motif; other site 768486002344 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 768486002345 dimerization interface [polypeptide binding]; other site 768486002346 ligand binding site [chemical binding]; other site 768486002347 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 768486002348 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768486002349 S-adenosylmethionine binding site [chemical binding]; other site 768486002350 pantothenate kinase; Provisional; Region: PRK05439 768486002351 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 768486002352 ATP-binding site [chemical binding]; other site 768486002353 CoA-binding site [chemical binding]; other site 768486002354 Mg2+-binding site [ion binding]; other site 768486002355 GMP synthase; Reviewed; Region: guaA; PRK00074 768486002356 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 768486002357 AMP/PPi binding site [chemical binding]; other site 768486002358 candidate oxyanion hole; other site 768486002359 catalytic triad [active] 768486002360 potential glutamine specificity residues [chemical binding]; other site 768486002361 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 768486002362 ATP Binding subdomain [chemical binding]; other site 768486002363 Dimerization subdomain; other site 768486002364 Mga helix-turn-helix domain; Region: Mga; pfam05043 768486002365 Protein of unknown function (DUF1211); Region: DUF1211; cl01421 768486002366 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 768486002367 ZIP Zinc transporter; Region: Zip; pfam02535 768486002368 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 768486002369 pyruvate oxidase; Region: pyruv_oxi_spxB; TIGR02720 768486002370 PYR/PP interface [polypeptide binding]; other site 768486002371 dimer interface [polypeptide binding]; other site 768486002372 tetramer interface [polypeptide binding]; other site 768486002373 TPP binding site [chemical binding]; other site 768486002374 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 768486002375 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 768486002376 TPP-binding site [chemical binding]; other site 768486002377 Short repeat of unknown function (DUF308); Region: DUF308; cl15828 768486002378 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 768486002379 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768486002380 Walker A/P-loop; other site 768486002381 ATP binding site [chemical binding]; other site 768486002382 Q-loop/lid; other site 768486002383 ABC transporter signature motif; other site 768486002384 Walker B; other site 768486002385 D-loop; other site 768486002386 H-loop/switch region; other site 768486002387 ABC transporter; Region: ABC_tran_2; pfam12848 768486002388 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 768486002389 EDD domain protein, DegV family; Region: DegV; TIGR00762 768486002390 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 768486002391 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 768486002392 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 768486002393 GDP-binding site [chemical binding]; other site 768486002394 ACT binding site; other site 768486002395 IMP binding site; other site 768486002396 replicative DNA helicase; Provisional; Region: PRK05748 768486002397 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 768486002398 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 768486002399 Walker A motif; other site 768486002400 ATP binding site [chemical binding]; other site 768486002401 Walker B motif; other site 768486002402 DNA binding loops [nucleotide binding] 768486002403 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520 768486002404 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 768486002405 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 768486002406 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 768486002407 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 768486002408 DHH family; Region: DHH; pfam01368 768486002409 DHHA1 domain; Region: DHHA1; pfam02272 768486002410 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 768486002411 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 768486002412 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 768486002413 dimer interface [polypeptide binding]; other site 768486002414 ssDNA binding site [nucleotide binding]; other site 768486002415 tetramer (dimer of dimers) interface [polypeptide binding]; other site 768486002416 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 768486002417 DNA gyrase subunit A; Validated; Region: PRK05560 768486002418 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 768486002419 CAP-like domain; other site 768486002420 active site 768486002421 primary dimer interface [polypeptide binding]; other site 768486002422 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 768486002423 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 768486002424 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 768486002425 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 768486002426 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 768486002427 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 768486002428 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768486002429 Mg2+ binding site [ion binding]; other site 768486002430 G-X-G motif; other site 768486002431 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 768486002432 anchoring element; other site 768486002433 dimer interface [polypeptide binding]; other site 768486002434 ATP binding site [chemical binding]; other site 768486002435 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 768486002436 active site 768486002437 putative metal-binding site [ion binding]; other site 768486002438 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 768486002439 S4 domain protein YaaA; Region: YaaA_near_RecF; TIGR02988 768486002440 DNA polymerase III subunit beta; Validated; Region: PRK05643 768486002441 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 768486002442 putative DNA binding surface [nucleotide binding]; other site 768486002443 dimer interface [polypeptide binding]; other site 768486002444 beta-clamp/clamp loader binding surface; other site 768486002445 beta-clamp/translesion DNA polymerase binding surface; other site 768486002446 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 768486002447 DnaA N-terminal domain; Region: DnaA_N; pfam11638 768486002448 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768486002449 Walker A motif; other site 768486002450 ATP binding site [chemical binding]; other site 768486002451 Walker B motif; other site 768486002452 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 768486002453 arginine finger; other site 768486002454 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 768486002455 DnaA box-binding interface [nucleotide binding]; other site 768486002456 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 768486002457 ribonuclease P; Reviewed; Region: rnpA; PRK00499 768486002458 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 768486002459 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 768486002460 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 768486002461 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 768486002462 G-X-X-G motif; other site 768486002463 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 768486002464 RxxxH motif; other site 768486002465 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 768486002466 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 768486002467 trmE is a tRNA modification GTPase; Region: trmE; cd04164 768486002468 G1 box; other site 768486002469 GTP/Mg2+ binding site [chemical binding]; other site 768486002470 Switch I region; other site 768486002471 G2 box; other site 768486002472 Switch II region; other site 768486002473 G3 box; other site 768486002474 G4 box; other site 768486002475 G5 box; other site 768486002476 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 768486002477 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 768486002478 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 768486002479 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 768486002480 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 768486002481 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 768486002482 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 768486002483 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 768486002484 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 768486002485 P-loop; other site 768486002486 Magnesium ion binding site [ion binding]; other site 768486002487 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 768486002488 Magnesium ion binding site [ion binding]; other site 768486002489 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 768486002490 potential frameshift: common BLAST hit: gi|332687255|ref|YP_004457029.1| chromosome (plasmid) partitioning protein ParB/ stage 0 sporulation 768486002491 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 768486002492 GTP-binding protein YchF; Reviewed; Region: PRK09601 768486002493 YchF GTPase; Region: YchF; cd01900 768486002494 G1 box; other site 768486002495 GTP/Mg2+ binding site [chemical binding]; other site 768486002496 Switch I region; other site 768486002497 G2 box; other site 768486002498 Switch II region; other site 768486002499 G3 box; other site 768486002500 G4 box; other site 768486002501 G5 box; other site 768486002502 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 768486002503 Protein of unknown function (DUF1129); Region: DUF1129; pfam06570 768486002504 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 768486002505 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 768486002506 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 768486002507 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 768486002508 active site 768486002509 seryl-tRNA synthetase; Provisional; Region: PRK05431 768486002510 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 768486002511 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 768486002512 dimer interface [polypeptide binding]; other site 768486002513 active site 768486002514 motif 1; other site 768486002515 motif 2; other site 768486002516 motif 3; other site 768486002517 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 768486002518 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768486002519 dimer interface [polypeptide binding]; other site 768486002520 phosphorylation site [posttranslational modification] 768486002521 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768486002522 ATP binding site [chemical binding]; other site 768486002523 Mg2+ binding site [ion binding]; other site 768486002524 G-X-G motif; other site 768486002525 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 768486002526 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768486002527 active site 768486002528 phosphorylation site [posttranslational modification] 768486002529 intermolecular recognition site; other site 768486002530 dimerization interface [polypeptide binding]; other site 768486002531 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 768486002532 DNA binding site [nucleotide binding] 768486002533 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848 768486002534 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 768486002535 Clp amino terminal domain; Region: Clp_N; pfam02861 768486002536 Clp amino terminal domain; Region: Clp_N; pfam02861 768486002537 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768486002538 Walker A motif; other site 768486002539 ATP binding site [chemical binding]; other site 768486002540 Walker B motif; other site 768486002541 arginine finger; other site 768486002542 UvrB/uvrC motif; Region: UVR; pfam02151 768486002543 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768486002544 Walker A motif; other site 768486002545 ATP binding site [chemical binding]; other site 768486002546 Walker B motif; other site 768486002547 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 768486002548 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 768486002549 Peptidase family U32; Region: Peptidase_U32; pfam01136 768486002550 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 768486002551 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 768486002552 Peptidase family U32; Region: Peptidase_U32; pfam01136 768486002553 glutathione reductase; Validated; Region: PRK06116 768486002554 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 768486002555 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 768486002556 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 768486002557 Mga helix-turn-helix domain; Region: Mga; pfam05043 768486002558 Mga helix-turn-helix domain; Region: Mga; pfam05043 768486002559 Type IV secretion-system coupling protein DNA-binding domain; Region: TrwB_AAD_bind; pfam10412 768486002560 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 768486002561 Walker A motif; other site 768486002562 ATP binding site [chemical binding]; other site 768486002563 Walker B motif; other site 768486002564 PrgI family protein; Region: PrgI; pfam12666 768486002565 CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 768486002566 AAA-like domain; Region: AAA_10; pfam12846 768486002567 Domain of unknown function DUF87; Region: DUF87; pfam01935 768486002568 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 768486002569 N-acetyl-D-glucosamine binding site [chemical binding]; other site 768486002570 catalytic residue [active] 768486002571 Uncharacterized protein conserved in bacteria (DUF2272); Region: DUF2272; cl01776 768486002572 1,4-dihydroxy-2-naphthoate octaprenyltransferase [Coenzyme metabolism]; Region: MenA; cl17224 768486002573 UbiA prenyltransferase family; Region: UbiA; pfam01040 768486002574 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 768486002575 ApbE family; Region: ApbE; pfam02424 768486002576 This conserved region includes the FMN-binding site of the NqrC protein as well as the NosR and NirI regulatory proteins; Region: FMN_bind; smart00900 768486002577 This conserved region includes the FMN-binding site of the NqrC protein as well as the NosR and NirI regulatory proteins; Region: FMN_bind; smart00900 768486002578 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 768486002579 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 768486002580 Listerrria innocua Lin0431 is similar to the N-Utilization Substance G (NusG) N terminal (NGN) insert (DII); Region: Lin0431_like; cd09911 768486002581 trimer interface [polypeptide binding]; other site 768486002582 Heptaprenyl diphosphate synthase component I; Region: Hpre_diP_synt_I; pfam07456 768486002583 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 768486002584 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 768486002585 substrate binding pocket [chemical binding]; other site 768486002586 chain length determination region; other site 768486002587 substrate-Mg2+ binding site; other site 768486002588 catalytic residues [active] 768486002589 aspartate-rich region 1; other site 768486002590 active site lid residues [active] 768486002591 aspartate-rich region 2; other site 768486002592 potential frameshift: common BLAST hit: gi|29377684|ref|NP_816838.1| BirA bifunctional protein 768486002593 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 768486002594 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768486002595 Walker A/P-loop; other site 768486002596 ATP binding site [chemical binding]; other site 768486002597 Q-loop/lid; other site 768486002598 ABC transporter signature motif; other site 768486002599 Walker B; other site 768486002600 D-loop; other site 768486002601 H-loop/switch region; other site 768486002602 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 768486002603 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 768486002604 TM-ABC transporter signature motif; other site 768486002605 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 768486002606 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 768486002607 zinc binding site [ion binding]; other site 768486002608 putative ligand binding site [chemical binding]; other site 768486002609 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 768486002610 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 768486002611 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 768486002612 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 768486002613 RPB1 interaction site [polypeptide binding]; other site 768486002614 RPB10 interaction site [polypeptide binding]; other site 768486002615 RPB11 interaction site [polypeptide binding]; other site 768486002616 RPB3 interaction site [polypeptide binding]; other site 768486002617 RPB12 interaction site [polypeptide binding]; other site 768486002618 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 768486002619 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 768486002620 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 768486002621 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 768486002622 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 768486002623 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 768486002624 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 768486002625 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 768486002626 DNA binding site [nucleotide binding] 768486002627 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 768486002628 methionine sulfoxide reductase A; Provisional; Region: PRK14054 768486002629 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 768486002630 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 768486002631 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 768486002632 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 768486002633 N- and C-terminal domain interface [polypeptide binding]; other site 768486002634 active site 768486002635 catalytic site [active] 768486002636 metal binding site [ion binding]; metal-binding site 768486002637 carbohydrate binding site [chemical binding]; other site 768486002638 ATP binding site [chemical binding]; other site 768486002639 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 768486002640 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 768486002641 dimerization interface [polypeptide binding]; other site 768486002642 DPS ferroxidase diiron center [ion binding]; other site 768486002643 ion pore; other site 768486002644 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 768486002645 23S rRNA interface [nucleotide binding]; other site 768486002646 L3 interface [polypeptide binding]; other site 768486002647 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 768486002648 Toxin Fst, type I toxin-antitoxin system; Region: Fst_toxin; pfam13955 768486002649 HTH domain; Region: HTH_11; cl17392 768486002650 PRD domain; Region: PRD; pfam00874 768486002651 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 768486002652 active site 768486002653 P-loop; other site 768486002654 phosphorylation site [posttranslational modification] 768486002655 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 768486002656 active site 768486002657 phosphorylation site [posttranslational modification] 768486002658 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 768486002659 active site 768486002660 phosphorylation site [posttranslational modification] 768486002661 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 768486002662 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 768486002663 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 768486002664 active site 768486002665 P-loop; other site 768486002666 phosphorylation site [posttranslational modification] 768486002667 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 768486002668 intersubunit interface [polypeptide binding]; other site 768486002669 active site 768486002670 zinc binding site [ion binding]; other site 768486002671 Na+ binding site [ion binding]; other site 768486002672 triosephosphate isomerase; Provisional; Region: PRK04302 768486002673 phosphate binding site [ion binding]; other site 768486002674 Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894 768486002675 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 768486002676 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768486002677 active site 768486002678 phosphorylation site [posttranslational modification] 768486002679 intermolecular recognition site; other site 768486002680 dimerization interface [polypeptide binding]; other site 768486002681 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 768486002682 DNA binding residues [nucleotide binding] 768486002683 dimerization interface [polypeptide binding]; other site 768486002684 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 768486002685 Histidine kinase; Region: HisKA_3; pfam07730 768486002686 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768486002687 ATP binding site [chemical binding]; other site 768486002688 Mg2+ binding site [ion binding]; other site 768486002689 G-X-G motif; other site 768486002690 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 768486002691 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 768486002692 Walker A/P-loop; other site 768486002693 ATP binding site [chemical binding]; other site 768486002694 Q-loop/lid; other site 768486002695 ABC transporter signature motif; other site 768486002696 Walker B; other site 768486002697 D-loop; other site 768486002698 H-loop/switch region; other site 768486002699 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 768486002700 beta-galactosidase; Region: BGL; TIGR03356 768486002701 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 768486002702 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768486002703 Walker A/P-loop; other site 768486002704 ATP binding site [chemical binding]; other site 768486002705 Q-loop/lid; other site 768486002706 ABC transporter signature motif; other site 768486002707 Walker B; other site 768486002708 D-loop; other site 768486002709 H-loop/switch region; other site 768486002710 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 768486002711 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 768486002712 Walker A/P-loop; other site 768486002713 ATP binding site [chemical binding]; other site 768486002714 Q-loop/lid; other site 768486002715 ABC transporter signature motif; other site 768486002716 Walker B; other site 768486002717 D-loop; other site 768486002718 H-loop/switch region; other site 768486002719 inner membrane transport permease; Provisional; Region: PRK15066 768486002720 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 768486002721 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768486002722 Coenzyme A binding pocket [chemical binding]; other site 768486002723 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 768486002724 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 768486002725 FMN binding site [chemical binding]; other site 768486002726 active site 768486002727 catalytic residues [active] 768486002728 substrate binding site [chemical binding]; other site 768486002729 phytoene desaturase; Region: crtI_fam; TIGR02734 768486002730 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 768486002731 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 768486002732 active site lid residues [active] 768486002733 substrate binding pocket [chemical binding]; other site 768486002734 catalytic residues [active] 768486002735 substrate-Mg2+ binding site; other site 768486002736 aspartate-rich region 1; other site 768486002737 aspartate-rich region 2; other site 768486002738 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 768486002739 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; cl17489 768486002740 WXG100 protein secretion system (Wss), protein YukC; Region: YukC; cl01868 768486002741 potential frameshift: common BLAST hit: gi|337738916|ref|YP_004638363.1| DNA segregation ATPase 768486002742 Predicted transcriptional regulator [Transcription]; Region: COG1959 768486002743 Transcriptional regulator; Region: Rrf2; pfam02082 768486002744 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 768486002745 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 768486002746 NADP binding site [chemical binding]; other site 768486002747 Predicted transcriptional regulators [Transcription]; Region: COG1695 768486002748 Transcriptional regulator PadR-like family; Region: PadR; cl17335 768486002749 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 768486002750 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768486002751 Major Facilitator Superfamily; Region: MFS_1; pfam07690 768486002752 putative substrate translocation pore; other site 768486002753 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 768486002754 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 768486002755 putative catalytic cysteine [active] 768486002756 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 768486002757 nucleotide binding site [chemical binding]; other site 768486002758 homotetrameric interface [polypeptide binding]; other site 768486002759 putative phosphate binding site [ion binding]; other site 768486002760 putative allosteric binding site; other site 768486002761 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 768486002762 trimer interface [polypeptide binding]; other site 768486002763 active site 768486002764 DNA repair protein RadA; Provisional; Region: PRK11823 768486002765 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 768486002766 Walker A motif/ATP binding site; other site 768486002767 ATP binding site [chemical binding]; other site 768486002768 Walker B motif; other site 768486002769 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 768486002770 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 768486002771 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 768486002772 putative active site [active] 768486002773 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 768486002774 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 768486002775 HIGH motif; other site 768486002776 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 768486002777 active site 768486002778 KMSKS motif; other site 768486002779 serine O-acetyltransferase; Region: cysE; TIGR01172 768486002780 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 768486002781 trimer interface [polypeptide binding]; other site 768486002782 active site 768486002783 substrate binding site [chemical binding]; other site 768486002784 CoA binding site [chemical binding]; other site 768486002785 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 768486002786 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 768486002787 active site 768486002788 HIGH motif; other site 768486002789 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 768486002790 KMSKS motif; other site 768486002791 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 768486002792 tRNA binding surface [nucleotide binding]; other site 768486002793 anticodon binding site; other site 768486002794 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 768486002795 active site 768486002796 metal binding site [ion binding]; metal-binding site 768486002797 dimerization interface [polypeptide binding]; other site 768486002798 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 768486002799 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 768486002800 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 768486002801 YacP-like NYN domain; Region: NYN_YacP; pfam05991 768486002802 RNA polymerase factor sigma-70; Validated; Region: PRK08295 768486002803 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 768486002804 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 768486002805 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 768486002806 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 768486002807 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 768486002808 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 768486002809 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 768486002810 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 768486002811 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 768486002812 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 768486002813 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 768486002814 Helix-turn-helix domain; Region: HTH_25; pfam13413 768486002815 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 768486002816 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Region: pgsA; TIGR00560 768486002817 competence damage-inducible protein A; Provisional; Region: PRK00549 768486002818 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 768486002819 putative MPT binding site; other site 768486002820 Competence-damaged protein; Region: CinA; pfam02464 768486002821 recombinase A; Provisional; Region: recA; PRK09354 768486002822 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 768486002823 hexamer interface [polypeptide binding]; other site 768486002824 Walker A motif; other site 768486002825 ATP binding site [chemical binding]; other site 768486002826 Walker B motif; other site 768486002827 Domain of unknown function (DUF3552); Region: DUF3552; pfam12072 768486002828 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 768486002829 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 768486002830 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 768486002831 Zn2+ binding site [ion binding]; other site 768486002832 Mg2+ binding site [ion binding]; other site 768486002833 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 768486002834 Lanthionine synthetase C-like protein; Region: LANC_like; pfam05147 768486002835 active site 768486002836 zinc binding site [ion binding]; other site 768486002837 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 768486002838 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 768486002839 Predicted integral membrane protein [Function unknown]; Region: COG0392 768486002840 Uncharacterized conserved protein [Function unknown]; Region: COG2898 768486002841 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 768486002842 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 768486002843 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 768486002844 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 768486002845 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 768486002846 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 768486002847 metal binding site [ion binding]; metal-binding site 768486002848 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 768486002849 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 768486002850 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 768486002851 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 768486002852 ABC-ATPase subunit interface; other site 768486002853 dimer interface [polypeptide binding]; other site 768486002854 putative PBP binding regions; other site 768486002855 pur operon repressor; Provisional; Region: PRK09213 768486002856 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 768486002857 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 768486002858 active site 768486002859 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 768486002860 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 768486002861 Substrate binding site; other site 768486002862 Mg++ binding site; other site 768486002863 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 768486002864 active site 768486002865 substrate binding site [chemical binding]; other site 768486002866 CoA binding site [chemical binding]; other site 768486002867 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 768486002868 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 768486002869 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 768486002870 active site 768486002871 Thiamine transporter protein (Thia_YuaJ); Region: Thia_YuaJ; pfam09515 768486002872 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 768486002873 nucleophile elbow; other site 768486002874 Uncharacterized protein conserved in bacteria (DUF2128); Region: DUF2128; pfam09901 768486002875 hypothetical protein; Provisional; Region: PRK11820 768486002876 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 768486002877 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 768486002878 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 768486002879 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 768486002880 catalytic site [active] 768486002881 G-X2-G-X-G-K; other site 768486002882 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 768486002883 primosome assembly protein PriA; Validated; Region: PRK05580 768486002884 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 768486002885 primosomal protein N' Region: priA; TIGR00595 768486002886 ATP binding site [chemical binding]; other site 768486002887 putative Mg++ binding site [ion binding]; other site 768486002888 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 768486002889 nucleotide binding region [chemical binding]; other site 768486002890 ATP-binding site [chemical binding]; other site 768486002891 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 768486002892 active site 768486002893 catalytic residues [active] 768486002894 metal binding site [ion binding]; metal-binding site 768486002895 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 768486002896 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 768486002897 putative active site [active] 768486002898 substrate binding site [chemical binding]; other site 768486002899 putative cosubstrate binding site; other site 768486002900 catalytic site [active] 768486002901 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 768486002902 substrate binding site [chemical binding]; other site 768486002903 16S rRNA methyltransferase B; Provisional; Region: PRK14902 768486002904 NusB family; Region: NusB; pfam01029 768486002905 putative RNA binding site [nucleotide binding]; other site 768486002906 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768486002907 S-adenosylmethionine binding site [chemical binding]; other site 768486002908 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 768486002909 active site 768486002910 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 768486002911 Catalytic domain of Protein Kinases; Region: PKc; cd00180 768486002912 active site 768486002913 ATP binding site [chemical binding]; other site 768486002914 substrate binding site [chemical binding]; other site 768486002915 activation loop (A-loop); other site 768486002916 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 768486002917 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 768486002918 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 768486002919 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 768486002920 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 768486002921 GTPase RsgA; Reviewed; Region: PRK00098 768486002922 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 768486002923 RNA binding site [nucleotide binding]; other site 768486002924 homodimer interface [polypeptide binding]; other site 768486002925 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 768486002926 GTPase/Zn-binding domain interface [polypeptide binding]; other site 768486002927 GTP/Mg2+ binding site [chemical binding]; other site 768486002928 G4 box; other site 768486002929 G5 box; other site 768486002930 G1 box; other site 768486002931 Switch I region; other site 768486002932 G2 box; other site 768486002933 G3 box; other site 768486002934 Switch II region; other site 768486002935 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 768486002936 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 768486002937 substrate binding site [chemical binding]; other site 768486002938 hexamer interface [polypeptide binding]; other site 768486002939 metal binding site [ion binding]; metal-binding site 768486002940 Thiamine pyrophosphokinase; Region: TPK; cd07995 768486002941 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 768486002942 active site 768486002943 dimerization interface [polypeptide binding]; other site 768486002944 thiamine binding site [chemical binding]; other site 768486002945 rod shape-determining protein MreC; Provisional; Region: PRK13922 768486002946 rod shape-determining protein MreC; Region: MreC; pfam04085 768486002947 rod shape-determining protein MreD; Region: MreD; pfam04093 768486002948 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 768486002949 Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; Region: SPEC; cl02488 768486002950 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 768486002951 NlpC/P60 family; Region: NLPC_P60; pfam00877 768486002952 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 768486002953 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_2; cd09607 768486002954 active site 768486002955 Zn binding site [ion binding]; other site 768486002956 Predicted integral membrane protein [Function unknown]; Region: COG5652 768486002957 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 768486002958 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 768486002959 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 768486002960 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 768486002961 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 768486002962 tetramer (dimer of dimers) interface [polypeptide binding]; other site 768486002963 NAD binding site [chemical binding]; other site 768486002964 dimer interface [polypeptide binding]; other site 768486002965 substrate binding site [chemical binding]; other site 768486002966 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 768486002967 putative active site [active] 768486002968 catalytic residue [active] 768486002969 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 768486002970 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 768486002971 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 768486002972 ATP binding site [chemical binding]; other site 768486002973 putative Mg++ binding site [ion binding]; other site 768486002974 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 768486002975 nucleotide binding region [chemical binding]; other site 768486002976 ATP-binding site [chemical binding]; other site 768486002977 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 768486002978 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 768486002979 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 768486002980 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 768486002981 RNA binding surface [nucleotide binding]; other site 768486002982 Septum formation initiator; Region: DivIC; pfam04977 768486002983 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 768486002984 hypothetical protein; Provisional; Region: PRK08582 768486002985 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 768486002986 RNA binding site [nucleotide binding]; other site 768486002987 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 768486002988 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 768486002989 Ligand Binding Site [chemical binding]; other site 768486002990 TilS substrate C-terminal domain; Region: TilS_C; smart00977 768486002991 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 768486002992 active site 768486002993 FtsH Extracellular; Region: FtsH_ext; pfam06480 768486002994 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 768486002995 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768486002996 Walker A motif; other site 768486002997 ATP binding site [chemical binding]; other site 768486002998 Walker B motif; other site 768486002999 arginine finger; other site 768486003000 Peptidase family M41; Region: Peptidase_M41; pfam01434 768486003001 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 768486003002 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 768486003003 dimerization interface [polypeptide binding]; other site 768486003004 domain crossover interface; other site 768486003005 redox-dependent activation switch; other site 768486003006 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 768486003007 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 768486003008 FMN binding site [chemical binding]; other site 768486003009 active site 768486003010 catalytic residues [active] 768486003011 substrate binding site [chemical binding]; other site 768486003012 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 768486003013 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 768486003014 dimer interface [polypeptide binding]; other site 768486003015 putative anticodon binding site; other site 768486003016 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 768486003017 motif 1; other site 768486003018 active site 768486003019 motif 2; other site 768486003020 motif 3; other site 768486003021 S-adenosylmethionine synthetase; Validated; Region: PRK05250 768486003022 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 768486003023 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 768486003024 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 768486003025 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768486003026 putative substrate translocation pore; other site 768486003027 Major Facilitator Superfamily; Region: MFS_1; pfam07690 768486003028 Predicted esterase [General function prediction only]; Region: COG0627 768486003029 S-formylglutathione hydrolase; Region: PLN02442 768486003030 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 768486003031 tetracycline repressor protein TetR; Provisional; Region: PRK13756 768486003032 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 768486003033 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 768486003034 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 768486003035 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 768486003036 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768486003037 Walker A/P-loop; other site 768486003038 ATP binding site [chemical binding]; other site 768486003039 Q-loop/lid; other site 768486003040 ABC transporter signature motif; other site 768486003041 Walker B; other site 768486003042 D-loop; other site 768486003043 H-loop/switch region; other site 768486003044 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 768486003045 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 768486003046 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 768486003047 Walker A/P-loop; other site 768486003048 ATP binding site [chemical binding]; other site 768486003049 Q-loop/lid; other site 768486003050 ABC transporter signature motif; other site 768486003051 Walker B; other site 768486003052 D-loop; other site 768486003053 H-loop/switch region; other site 768486003054 CopC domain; Region: CopC; cl01012 768486003055 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 768486003056 Cna protein B-type domain; Region: Cna_B; pfam05738 768486003057 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 768486003058 active site 768486003059 catalytic site [active] 768486003060 Methyltransferase domain; Region: Methyltransf_31; pfam13847 768486003061 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 768486003062 Putative rRNA methylase; Region: rRNA_methylase; pfam06962 768486003063 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 768486003064 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 768486003065 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 768486003066 active site 768486003067 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 768486003068 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 768486003069 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 768486003070 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 768486003071 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 768486003072 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 768486003073 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 768486003074 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 768486003075 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 768486003076 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 768486003077 HIGH motif; other site 768486003078 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 768486003079 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 768486003080 active site 768486003081 KMSKS motif; other site 768486003082 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 768486003083 tRNA binding surface [nucleotide binding]; other site 768486003084 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 768486003085 active site 768486003086 P-loop; other site 768486003087 phosphorylation site [posttranslational modification] 768486003088 potential frameshift: common BLAST hit: gi|300172920|ref|YP_003772085.1| BglG family transcriptional regulator 768486003089 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 768486003090 methionine cluster; other site 768486003091 active site 768486003092 phosphorylation site [posttranslational modification] 768486003093 metal binding site [ion binding]; metal-binding site 768486003094 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 768486003095 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 768486003096 UDP-N-acetylmuramoylalanyl-D-glutamate--L-lysine ligase; Provisional; Region: PRK14022 768486003097 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 768486003098 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 768486003099 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 768486003100 Uncharacterized conserved protein [Function unknown]; Region: COG1284 768486003101 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 768486003102 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 768486003103 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 768486003104 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 768486003105 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 768486003106 RNA binding surface [nucleotide binding]; other site 768486003107 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 768486003108 active site 768486003109 uracil binding [chemical binding]; other site 768486003110 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 768486003111 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 768486003112 active site 768486003113 P-loop; other site 768486003114 phosphorylation site [posttranslational modification] 768486003115 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 768486003116 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 768486003117 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 768486003118 methionine cluster; other site 768486003119 active site 768486003120 phosphorylation site [posttranslational modification] 768486003121 metal binding site [ion binding]; metal-binding site 768486003122 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 768486003123 nucleotide binding site [chemical binding]; other site 768486003124 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 768486003125 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 768486003126 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 768486003127 putative active site [active] 768486003128 WxL domain surface cell wall-binding; Region: WxL; pfam13731 768486003129 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 768486003130 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 768486003131 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 768486003132 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 768486003133 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 768486003134 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768486003135 dimer interface [polypeptide binding]; other site 768486003136 conserved gate region; other site 768486003137 ABC-ATPase subunit interface; other site 768486003138 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 768486003139 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768486003140 dimer interface [polypeptide binding]; other site 768486003141 conserved gate region; other site 768486003142 putative PBP binding loops; other site 768486003143 ABC-ATPase subunit interface; other site 768486003144 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 768486003145 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 768486003146 Domain of unknown function (DUF3502); Region: DUF3502; pfam12010 768486003147 Protein of unknown function, DUF624; Region: DUF624; cl02369 768486003148 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 768486003149 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 768486003150 Histidine kinase; Region: His_kinase; pfam06580 768486003151 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768486003152 ATP binding site [chemical binding]; other site 768486003153 Mg2+ binding site [ion binding]; other site 768486003154 G-X-G motif; other site 768486003155 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 768486003156 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768486003157 active site 768486003158 phosphorylation site [posttranslational modification] 768486003159 intermolecular recognition site; other site 768486003160 dimerization interface [polypeptide binding]; other site 768486003161 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768486003162 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 768486003163 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 768486003164 dimerization interface 3.5A [polypeptide binding]; other site 768486003165 active site 768486003166 Enterocin A Immunity; Region: EntA_Immun; pfam08951 768486003167 methionine sulfoxide reductase A; Provisional; Region: PRK14054 768486003168 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 768486003169 active site 768486003170 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 768486003171 catalytic tetrad [active] 768486003172 Protein of unknown function (DUF1003); Region: DUF1003; pfam06210 768486003173 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 768486003174 active site 768486003175 P-loop; other site 768486003176 phosphorylation site [posttranslational modification] 768486003177 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 768486003178 active site 768486003179 methionine cluster; other site 768486003180 phosphorylation site [posttranslational modification] 768486003181 metal binding site [ion binding]; metal-binding site 768486003182 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 768486003183 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 768486003184 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768486003185 Coenzyme A binding pocket [chemical binding]; other site 768486003186 YrhK-like protein; Region: YrhK; pfam14145 768486003187 potential frameshift: common BLAST hit: gi|328956501|ref|YP_004373887.1| putative oxidoreductase 768486003188 Streptococcal 67 kDa myosin-cross-reactive antigen like family; Region: Strep_67kDa_ant; cl17487 768486003189 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 768486003190 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 768486003191 CRISPR/Cas system-associated protein Cas1; Region: Cas1_II; cd09720 768486003192 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09638 768486003193 CRISPR/Cas system-associated protein Csn2; Region: Csn2; cd09758 768486003194 CRISPR type II-A/NMEMI-associated protein Csn2; Region: cas_Csn2; TIGR01866 768486003195 tetramer interface [polypeptide binding]; other site 768486003196 putative DNA binding site [nucleotide binding]; other site 768486003197 Ca binding site [ion binding]; other site 768486003198 Ca binding site [ion binding]; other site 768486003199 Protein of unknown function (DUF1622); Region: DUF1622; pfam07784 768486003200 Protein of unknown function (DUF1622); Region: DUF1622; pfam07784 768486003201 potential frameshift: common BLAST hit: gi|383327657|ref|YP_005353541.1| M protein trans-acting positive regulator 768486003202 M protein trans-acting positive regulator (MGA) HTH domain; Region: HTH_Mga; pfam08280 768486003203 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 768486003204 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 768486003205 catalytic residue [active] 768486003206 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 768486003207 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 768486003208 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 768486003209 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 768486003210 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 768486003211 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 768486003212 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 768486003213 Soluble P-type ATPase [General function prediction only]; Region: COG4087 768486003214 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 768486003215 M protein trans-acting positive regulator (MGA) HTH domain; Region: HTH_Mga; pfam08280 768486003216 Mga helix-turn-helix domain; Region: Mga; pfam05043 768486003217 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 768486003218 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 768486003219 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 768486003220 nudix motif; other site 768486003221 MarR family; Region: MarR; pfam01047 768486003222 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 768486003223 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768486003224 Coenzyme A binding pocket [chemical binding]; other site 768486003225 Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382 768486003226 B3/4 domain; Region: B3_4; pfam03483 768486003227 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 768486003228 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 768486003229 active site 768486003230 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 768486003231 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 768486003232 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 768486003233 Ca binding site [ion binding]; other site 768486003234 active site 768486003235 catalytic site [active] 768486003236 LytTr DNA-binding domain; Region: LytTR; smart00850 768486003237 Protein of unknown function (DUF3021); Region: DUF3021; pfam11457 768486003238 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 768486003239 MarR family; Region: MarR; pfam01047 768486003240 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 768486003241 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 768486003242 putative active site [active] 768486003243 putative FMN binding site [chemical binding]; other site 768486003244 putative substrate binding site [chemical binding]; other site 768486003245 putative catalytic residue [active] 768486003246 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 768486003247 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 768486003248 potential catalytic triad [active] 768486003249 conserved cys residue [active] 768486003250 type I restriction enzyme EcoKI subunit R; Provisional; Region: hsdR; PRK11448 768486003251 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 768486003252 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 768486003253 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 768486003254 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 768486003255 potential frameshift: common BLAST hit: gi|281491766|ref|YP_003353746.1| trans-acting positive regulator 768486003256 potential frameshift: common BLAST hit: gi|15673228|ref|NP_267402.1| glycerol kinase 768486003257 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 768486003258 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 768486003259 amphipathic channel; other site 768486003260 Asn-Pro-Ala signature motifs; other site 768486003261 MutS domain III; Region: MutS_III; pfam05192 768486003262 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768486003263 Walker A/P-loop; other site 768486003264 ATP binding site [chemical binding]; other site 768486003265 Q-loop/lid; other site 768486003266 ABC transporter signature motif; other site 768486003267 Walker B; other site 768486003268 D-loop; other site 768486003269 H-loop/switch region; other site 768486003270 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 768486003271 DsrE/DsrF-like family; Region: DrsE; cl00672 768486003272 Uncharacterized protein YrkD from Bacillus subtilis and related domains; this domain superfamily was previously known as part of DUF156; Region: BsYrkD-like_DUF156; cd10155 768486003273 putative homodimer interface [polypeptide binding]; other site 768486003274 putative homotetramer interface [polypeptide binding]; other site 768486003275 putative metal binding site [ion binding]; other site 768486003276 putative homodimer-homodimer interface [polypeptide binding]; other site 768486003277 putative allosteric switch controlling residues; other site 768486003278 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 768486003279 active site residue [active] 768486003280 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 768486003281 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 768486003282 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 768486003283 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 768486003284 Member of the Rhodanese Homology Domain superfamily. Included in this CD are the Lactococcus lactis NADH oxidase, Bacillus cereus NADH dehydrogenase, and Bacteroides thetaiotaomicron pyridine nucleotide-disulphide oxidoreductase, and similar...; Region: RHOD_Pyr_redox; cd01524 768486003285 active site residue [active] 768486003286 Part of AAA domain; Region: AAA_19; pfam13245 768486003287 Family description; Region: UvrD_C_2; pfam13538 768486003288 potential frameshift: common BLAST hit: gi|15672858|ref|NP_267032.1| glycosyl transferase 768486003289 Cellulose synthase-like protein; Region: PLN02893 768486003290 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 768486003291 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 768486003292 DXD motif; other site 768486003293 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 768486003294 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 768486003295 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 768486003296 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 768486003297 tetramerization interface [polypeptide binding]; other site 768486003298 NAD(P) binding site [chemical binding]; other site 768486003299 catalytic residues [active] 768486003300 glycosyltransferase, TIGR04182 family; Region: glyco_TIGR04182 768486003301 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 768486003302 Ligand binding site; other site 768486003303 Putative Catalytic site; other site 768486003304 DXD motif; other site 768486003305 Predicted small secreted protein [Function unknown]; Region: COG5584 768486003306 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 768486003307 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 768486003308 oligomer interface [polypeptide binding]; other site 768486003309 active site 768486003310 metal binding site [ion binding]; metal-binding site 768486003311 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 768486003312 catalytic residues [active] 768486003313 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 768486003314 Ligand Binding Site [chemical binding]; other site 768486003315 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 768486003316 putative tRNA-binding site [nucleotide binding]; other site 768486003317 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 768486003318 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 768486003319 protein binding site [polypeptide binding]; other site 768486003320 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 768486003321 GIY-YIG domain of uncharacterized proteins from bacteria and their eukaryotic homologs; Region: GIY-YIG_COG3680; cd10440 768486003322 GIY-YIG motif/motif A; other site 768486003323 putative active site [active] 768486003324 putative metal binding site [ion binding]; other site 768486003325 6-pyruvoyl-tetrahydropterin synthase related domain; membrane protein; Region: PTPS_related; pfam10131 768486003326 6-pyruvoyl-tetrahydropterin synthase related domain; membrane protein; Region: PTPS_related; pfam10131 768486003327 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 768486003328 active site 768486003329 P-loop; other site 768486003330 phosphorylation site [posttranslational modification] 768486003331 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 768486003332 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 768486003333 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 768486003334 methionine cluster; other site 768486003335 active site 768486003336 phosphorylation site [posttranslational modification] 768486003337 metal binding site [ion binding]; metal-binding site 768486003338 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 768486003339 beta-galactosidase; Region: BGL; TIGR03356 768486003340 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 768486003341 HTH domain; Region: HTH_11; pfam08279 768486003342 Mga helix-turn-helix domain; Region: Mga; pfam05043 768486003343 PRD domain; Region: PRD; pfam00874 768486003344 PRD domain; Region: PRD; pfam00874 768486003345 Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2; Region: PTS_EIIA_2; pfam00359 768486003346 active site 768486003347 phosphorylation site [posttranslational modification] 768486003348 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 768486003349 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 768486003350 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 768486003351 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 768486003352 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 768486003353 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 768486003354 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 768486003355 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 768486003356 DNA-binding site [nucleotide binding]; DNA binding site 768486003357 Transcriptional regulators [Transcription]; Region: PurR; COG1609 768486003358 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 768486003359 ligand binding site [chemical binding]; other site 768486003360 dimerization interface [polypeptide binding]; other site 768486003361 Uncharacterized conserved protein [Function unknown]; Region: COG3538 768486003362 Protein of unknown function (DUF1237); Region: DUF1237; pfam06824 768486003363 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 768486003364 N-terminal catalytic domain of SPGH38, a putative alpha-mannosidase of Streptococcus pyogenes, and its prokaryotic homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_SpGH38_like; cd10814 768486003365 active site 768486003366 metal binding site [ion binding]; metal-binding site 768486003367 homodimer interface [polypeptide binding]; other site 768486003368 catalytic site [active] 768486003369 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 768486003370 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 768486003371 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 768486003372 nucleotide binding site [chemical binding]; other site 768486003373 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 768486003374 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 768486003375 active site 768486003376 Transglycosylase; Region: Transgly; pfam00912 768486003377 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 768486003378 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 768486003379 hypothetical protein; Provisional; Region: PRK13676 768486003380 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 768486003381 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 768486003382 active site 768486003383 metal binding site [ion binding]; metal-binding site 768486003384 DNA binding site [nucleotide binding] 768486003385 AAA domain; Region: AAA_23; pfam13476 768486003386 P-loop containing region of AAA domain; Region: AAA_29; cl17516 768486003387 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 768486003388 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 768486003389 generic binding surface II; other site 768486003390 generic binding surface I; other site 768486003391 integrating conjugative element relaxase, PFL_4751 family; Region: ICE_TraI_Pfluor; TIGR03760 768486003392 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 768486003393 Zn2+ binding site [ion binding]; other site 768486003394 Mg2+ binding site [ion binding]; other site 768486003395 foldase protein PrsA; Reviewed; Region: prsA; PRK01326 768486003396 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 768486003397 YtxH-like protein; Region: YtxH; pfam12732 768486003398 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 768486003399 HIT family signature motif; other site 768486003400 catalytic residue [active] 768486003401 potential frameshift: common BLAST hit: gi|29375285|ref|NP_814438.1| ABC transporter ATP-binding protein 768486003402 Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975 768486003403 Phosphotransferase enzyme family; Region: APH; pfam01636 768486003404 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 768486003405 active site 768486003406 substrate binding site [chemical binding]; other site 768486003407 ATP binding site [chemical binding]; other site 768486003408 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768486003409 S-adenosylmethionine binding site [chemical binding]; other site 768486003410 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 768486003411 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 768486003412 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 768486003413 active site 768486003414 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 768486003415 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 768486003416 Walker A motif; other site 768486003417 ATP binding site [chemical binding]; other site 768486003418 Walker B motif; other site 768486003419 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 768486003420 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 768486003421 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 768486003422 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 768486003423 Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940 768486003424 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 768486003425 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768486003426 S-adenosylmethionine binding site [chemical binding]; other site 768486003427 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 768486003428 propionate/acetate kinase; Provisional; Region: PRK12379 768486003429 nucleotide binding site [chemical binding]; other site 768486003430 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 768486003431 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 768486003432 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 768486003433 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 768486003434 Ligand Binding Site [chemical binding]; other site 768486003435 recombination factor protein RarA; Reviewed; Region: PRK13342 768486003436 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768486003437 Walker A motif; other site 768486003438 ATP binding site [chemical binding]; other site 768486003439 Walker B motif; other site 768486003440 arginine finger; other site 768486003441 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 768486003442 DinB superfamily; Region: DinB_2; pfam12867 768486003443 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 768486003444 active site 768486003445 DNA binding site [nucleotide binding] 768486003446 Protein of unknown function (DUF3013); Region: DUF3013; pfam11217 768486003447 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 768486003448 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768486003449 S-adenosylmethionine binding site [chemical binding]; other site 768486003450 Ribosomal protein L11 methylase [Translation, ribosomal structure and biogenesis]; Region: PrmA; COG2264 768486003451 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 768486003452 RNA methyltransferase, RsmE family; Region: TIGR00046 768486003453 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 768486003454 HD domain; Region: HD_4; pfam13328 768486003455 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 768486003456 synthetase active site [active] 768486003457 NTP binding site [chemical binding]; other site 768486003458 metal binding site [ion binding]; metal-binding site 768486003459 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 768486003460 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 768486003461 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 768486003462 putative active site [active] 768486003463 dimerization interface [polypeptide binding]; other site 768486003464 putative tRNAtyr binding site [nucleotide binding]; other site 768486003465 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 768486003466 Cytochrome P450; Region: p450; cl12078 768486003467 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 768486003468 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 768486003469 active site 768486003470 catalytic tetrad [active] 768486003471 histidyl-tRNA synthetase; Region: hisS; TIGR00442 768486003472 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 768486003473 dimer interface [polypeptide binding]; other site 768486003474 motif 1; other site 768486003475 active site 768486003476 motif 2; other site 768486003477 motif 3; other site 768486003478 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 768486003479 anticodon binding site; other site 768486003480 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 768486003481 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 768486003482 dimer interface [polypeptide binding]; other site 768486003483 anticodon binding site; other site 768486003484 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 768486003485 homodimer interface [polypeptide binding]; other site 768486003486 motif 1; other site 768486003487 active site 768486003488 motif 2; other site 768486003489 GAD domain; Region: GAD; pfam02938 768486003490 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 768486003491 motif 3; other site 768486003492 Uncharacterized conserved protein [Function unknown]; Region: COG1284 768486003493 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 768486003494 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 768486003495 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 768486003496 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 768486003497 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 768486003498 catalytic triad [active] 768486003499 catalytic triad [active] 768486003500 oxyanion hole [active] 768486003501 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 768486003502 GIY-YIG motif/motif A; other site 768486003503 putative active site [active] 768486003504 putative metal binding site [ion binding]; other site 768486003505 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 768486003506 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768486003507 S-adenosylmethionine binding site [chemical binding]; other site 768486003508 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 768486003509 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 768486003510 putative acyl-acceptor binding pocket; other site 768486003511 potential frameshift: common BLAST hit: gi|389869611|ref|YP_006377034.1| exonuclease SbcD 768486003512 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 768486003513 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 768486003514 active site 768486003515 metal binding site [ion binding]; metal-binding site 768486003516 DNA binding site [nucleotide binding] 768486003517 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 768486003518 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 768486003519 AAA domain; Region: AAA_23; pfam13476 768486003520 Walker A/P-loop; other site 768486003521 ATP binding site [chemical binding]; other site 768486003522 Q-loop/lid; other site 768486003523 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768486003524 ABC transporter signature motif; other site 768486003525 Walker B; other site 768486003526 D-loop; other site 768486003527 H-loop/switch region; other site 768486003528 SWIM zinc finger; Region: SWIM; pfam04434 768486003529 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 768486003530 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 768486003531 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 768486003532 ATP binding site [chemical binding]; other site 768486003533 putative Mg++ binding site [ion binding]; other site 768486003534 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 768486003535 nucleotide binding region [chemical binding]; other site 768486003536 ATP-binding site [chemical binding]; other site 768486003537 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 768486003538 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 768486003539 motif II; other site 768486003540 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 768486003541 ArsC family; Region: ArsC; pfam03960 768486003542 putative catalytic residues [active] 768486003543 thiol/disulfide switch; other site 768486003544 Negative regulator of genetic competence (MecA); Region: MecA; pfam05389 768486003545 Competence protein CoiA-like family; Region: CoiA; pfam06054 768486003546 Oligoendopeptidase F [Amino acid transport and metabolism]; Region: COG1164 768486003547 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 768486003548 active site 768486003549 Zn binding site [ion binding]; other site 768486003550 galactokinase; Provisional; Region: PRK05322 768486003551 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 768486003552 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 768486003553 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 768486003554 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 768486003555 active site 768486003556 catalytic residues [active] 768486003557 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 768486003558 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 768486003559 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 768486003560 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768486003561 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 768486003562 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768486003563 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 768486003564 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107 768486003565 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 768486003566 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 768486003567 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 768486003568 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 768486003569 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 768486003570 ABC-ATPase subunit interface; other site 768486003571 dimer interface [polypeptide binding]; other site 768486003572 putative PBP binding regions; other site 768486003573 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 768486003574 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 768486003575 metal binding site [ion binding]; metal-binding site 768486003576 epoxyqueuosine reductase; Region: TIGR00276 768486003577 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 768486003578 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 768486003579 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 768486003580 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768486003581 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 768486003582 putative substrate translocation pore; other site 768486003583 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 768486003584 Arginine repressor [Transcription]; Region: ArgR; COG1438 768486003585 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 768486003586 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 768486003587 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 768486003588 active site 768486003589 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 768486003590 substrate binding site [chemical binding]; other site 768486003591 metal binding site [ion binding]; metal-binding site 768486003592 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 768486003593 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 768486003594 dimanganese center [ion binding]; other site 768486003595 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 768486003596 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 768486003597 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 768486003598 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768486003599 dimer interface [polypeptide binding]; other site 768486003600 conserved gate region; other site 768486003601 putative PBP binding loops; other site 768486003602 ABC-ATPase subunit interface; other site 768486003603 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 768486003604 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768486003605 dimer interface [polypeptide binding]; other site 768486003606 conserved gate region; other site 768486003607 putative PBP binding loops; other site 768486003608 ABC-ATPase subunit interface; other site 768486003609 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 768486003610 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768486003611 active site 768486003612 phosphorylation site [posttranslational modification] 768486003613 intermolecular recognition site; other site 768486003614 dimerization interface [polypeptide binding]; other site 768486003615 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 768486003616 DNA binding site [nucleotide binding] 768486003617 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 768486003618 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 768486003619 dimer interface [polypeptide binding]; other site 768486003620 phosphorylation site [posttranslational modification] 768486003621 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768486003622 ATP binding site [chemical binding]; other site 768486003623 Mg2+ binding site [ion binding]; other site 768486003624 G-X-G motif; other site 768486003625 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 768486003626 amino acid transporter; Region: 2A0306; TIGR00909 768486003627 Spore germination protein; Region: Spore_permease; cl17796 768486003628 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 768486003629 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 768486003630 5-bromo-4-chloroindolyl phosphate hydrolysis protein; Region: Halogen_Hydrol; pfam10112 768486003631 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 768486003632 dimer interface [polypeptide binding]; other site 768486003633 ADP-ribose binding site [chemical binding]; other site 768486003634 active site 768486003635 nudix motif; other site 768486003636 metal binding site [ion binding]; metal-binding site 768486003637 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 768486003638 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 768486003639 Isochorismatase family; Region: Isochorismatase; pfam00857 768486003640 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 768486003641 catalytic triad [active] 768486003642 conserved cis-peptide bond; other site 768486003643 BioY family; Region: BioY; pfam02632 768486003644 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 768486003645 AAA domain; Region: AAA_26; pfam13500 768486003646 biotin synthase; Region: bioB; TIGR00433 768486003647 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 768486003648 FeS/SAM binding site; other site 768486003649 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 768486003650 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 768486003651 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 768486003652 active site 768486003653 Zn binding site [ion binding]; other site 768486003654 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 768486003655 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02458 768486003656 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 768486003657 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 768486003658 active site 768486003659 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 768486003660 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 768486003661 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 768486003662 catalytic residue [active] 768486003663 Putative amino acid metabolism; Region: DUF1831; pfam08866 768486003664 Aquifex aeolicus AQ1575 and related proteins, metallophosphatase domain; Region: MPP_AQ1575; cd07390 768486003665 putative active site [active] 768486003666 putative metal binding site [ion binding]; other site 768486003667 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 768486003668 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 768486003669 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 768486003670 transaminase; Validated; Region: PRK07324 768486003671 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 768486003672 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768486003673 homodimer interface [polypeptide binding]; other site 768486003674 catalytic residue [active] 768486003675 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768486003676 Major Facilitator Superfamily; Region: MFS_1; pfam07690 768486003677 putative substrate translocation pore; other site 768486003678 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 768486003679 WHG domain; Region: WHG; pfam13305 768486003680 Protein of unknown function (DUF1033); Region: DUF1033; pfam06279 768486003681 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 768486003682 DNA topoisomerase III; Provisional; Region: PRK07726 768486003683 active site 768486003684 putative metal-binding site [ion binding]; other site 768486003685 putative interdomain interaction site [polypeptide binding]; other site 768486003686 putative nucleotide binding site [chemical binding]; other site 768486003687 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 768486003688 domain I; other site 768486003689 DNA binding groove [nucleotide binding] 768486003690 phosphate binding site [ion binding]; other site 768486003691 domain II; other site 768486003692 domain III; other site 768486003693 nucleotide binding site [chemical binding]; other site 768486003694 catalytic site [active] 768486003695 domain IV; other site 768486003696 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 768486003697 This CD includes bacterial (Agrobacterium tumefaciens and Caulobacter crescentus ProX, and Clostridium sticklandii PrdX) and eukaryotic (Plasmodium falciparum N-terminal ProRS editing domain) sequences. The C. sticklandii PrdX protein, a homolog of the...; Region: PrdX_deacylase; cd04335 768486003698 putative deacylase active site [active] 768486003699 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768486003700 dimer interface [polypeptide binding]; other site 768486003701 conserved gate region; other site 768486003702 putative PBP binding loops; other site 768486003703 ABC-ATPase subunit interface; other site 768486003704 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 768486003705 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768486003706 Walker A/P-loop; other site 768486003707 ATP binding site [chemical binding]; other site 768486003708 Q-loop/lid; other site 768486003709 ABC transporter signature motif; other site 768486003710 Walker B; other site 768486003711 D-loop; other site 768486003712 H-loop/switch region; other site 768486003713 potential frameshift: common BLAST hit: gi|389869459|ref|YP_006376882.1| amino acid ABC superfamily ATP binding cassette transporter 768486003714 lipoprotein involved with copper homeostasis and adhesion; Provisional; Region: PRK10523 768486003715 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 768486003716 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 768486003717 substrate binding pocket [chemical binding]; other site 768486003718 membrane-bound complex binding site; other site 768486003719 hinge residues; other site 768486003720 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 768486003721 beta-galactosidase; Region: BGL; TIGR03356 768486003722 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 768486003723 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 768486003724 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 768486003725 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 768486003726 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 768486003727 FeS/SAM binding site; other site 768486003728 putative acetyltransferase; Provisional; Region: PRK03624 768486003729 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768486003730 Coenzyme A binding pocket [chemical binding]; other site 768486003731 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 768486003732 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 768486003733 peptide binding site [polypeptide binding]; other site 768486003734 Domain of unknown function (DUF3899); Region: DUF3899; pfam13038 768486003735 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 768486003736 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768486003737 dimer interface [polypeptide binding]; other site 768486003738 conserved gate region; other site 768486003739 putative PBP binding loops; other site 768486003740 ABC-ATPase subunit interface; other site 768486003741 dipeptide transporter; Provisional; Region: PRK10913 768486003742 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 768486003743 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768486003744 dimer interface [polypeptide binding]; other site 768486003745 conserved gate region; other site 768486003746 putative PBP binding loops; other site 768486003747 ABC-ATPase subunit interface; other site 768486003748 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 768486003749 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 768486003750 Walker A/P-loop; other site 768486003751 ATP binding site [chemical binding]; other site 768486003752 Q-loop/lid; other site 768486003753 ABC transporter signature motif; other site 768486003754 Walker B; other site 768486003755 D-loop; other site 768486003756 H-loop/switch region; other site 768486003757 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 768486003758 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 768486003759 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 768486003760 Walker A/P-loop; other site 768486003761 ATP binding site [chemical binding]; other site 768486003762 Q-loop/lid; other site 768486003763 ABC transporter signature motif; other site 768486003764 Walker B; other site 768486003765 D-loop; other site 768486003766 H-loop/switch region; other site 768486003767 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 768486003768 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 768486003769 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 768486003770 Probable transposase; Region: OrfB_IS605; pfam01385 768486003771 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 768486003772 nudix motif; other site 768486003773 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 768486003774 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 768486003775 active site 768486003776 HIGH motif; other site 768486003777 KMSKS motif; other site 768486003778 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 768486003779 tRNA binding surface [nucleotide binding]; other site 768486003780 anticodon binding site; other site 768486003781 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 768486003782 dimer interface [polypeptide binding]; other site 768486003783 putative tRNA-binding site [nucleotide binding]; other site 768486003784 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 768486003785 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 768486003786 KAP family P-loop domain; Region: KAP_NTPase; pfam07693 768486003787 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 768486003788 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 768486003789 non-specific DNA binding site [nucleotide binding]; other site 768486003790 salt bridge; other site 768486003791 sequence-specific DNA binding site [nucleotide binding]; other site 768486003792 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 768486003793 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 768486003794 catalytic motif [active] 768486003795 Zn binding site [ion binding]; other site 768486003796 RibD C-terminal domain; Region: RibD_C; cl17279 768486003797 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 768486003798 Lumazine binding domain; Region: Lum_binding; pfam00677 768486003799 Lumazine binding domain; Region: Lum_binding; pfam00677 768486003800 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 768486003801 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 768486003802 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 768486003803 dimerization interface [polypeptide binding]; other site 768486003804 active site 768486003805 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 768486003806 homopentamer interface [polypeptide binding]; other site 768486003807 active site 768486003808 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 768486003809 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 768486003810 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 768486003811 active site 768486003812 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 768486003813 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 768486003814 putative active site [active] 768486003815 putative metal binding site [ion binding]; other site 768486003816 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 768486003817 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 768486003818 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768486003819 S-adenosylmethionine binding site [chemical binding]; other site 768486003820 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 768486003821 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 768486003822 Walker A/P-loop; other site 768486003823 ATP binding site [chemical binding]; other site 768486003824 Q-loop/lid; other site 768486003825 ABC transporter signature motif; other site 768486003826 Walker B; other site 768486003827 D-loop; other site 768486003828 H-loop/switch region; other site 768486003829 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 768486003830 active site 768486003831 dimer interfaces [polypeptide binding]; other site 768486003832 catalytic residues [active] 768486003833 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl17272 768486003834 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 768486003835 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 768486003836 catalytic residues [active] 768486003837 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 768486003838 non-specific DNA binding site [nucleotide binding]; other site 768486003839 salt bridge; other site 768486003840 sequence-specific DNA binding site [nucleotide binding]; other site 768486003841 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 768486003842 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 768486003843 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 768486003844 Walker A/P-loop; other site 768486003845 ATP binding site [chemical binding]; other site 768486003846 Q-loop/lid; other site 768486003847 ABC transporter signature motif; other site 768486003848 Walker B; other site 768486003849 D-loop; other site 768486003850 H-loop/switch region; other site 768486003851 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 768486003852 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 768486003853 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768486003854 Walker A/P-loop; other site 768486003855 ATP binding site [chemical binding]; other site 768486003856 Q-loop/lid; other site 768486003857 ABC transporter signature motif; other site 768486003858 Walker B; other site 768486003859 D-loop; other site 768486003860 H-loop/switch region; other site 768486003861 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 768486003862 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768486003863 Walker A motif; other site 768486003864 ATP binding site [chemical binding]; other site 768486003865 Walker B motif; other site 768486003866 arginine finger; other site 768486003867 Transcriptional antiterminator [Transcription]; Region: COG3933 768486003868 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 768486003869 active pocket/dimerization site; other site 768486003870 active site 768486003871 phosphorylation site [posttranslational modification] 768486003872 PRD domain; Region: PRD; pfam00874 768486003873 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 768486003874 active pocket/dimerization site; other site 768486003875 active site 768486003876 phosphorylation site [posttranslational modification] 768486003877 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 768486003878 active site 768486003879 phosphorylation site [posttranslational modification] 768486003880 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 768486003881 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 768486003882 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 768486003883 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 768486003884 dimer interface [polypeptide binding]; other site 768486003885 active site 768486003886 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 768486003887 dimer interface [polypeptide binding]; other site 768486003888 active site 768486003889 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 768486003890 A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710 768486003891 putative active site [active] 768486003892 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 768486003893 Chitin binding domain; Region: Chitin_bind_3; pfam03067 768486003894 Chitin binding domain; Region: Chitin_bind_3; pfam03067 768486003895 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 768486003896 non-specific DNA binding site [nucleotide binding]; other site 768486003897 salt bridge; other site 768486003898 sequence-specific DNA binding site [nucleotide binding]; other site 768486003899 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 768486003900 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 768486003901 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 768486003902 active site 768486003903 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 768486003904 Interdomain contacts; other site 768486003905 Cytokine receptor motif; other site 768486003906 Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979 768486003907 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 768486003908 Interdomain contacts; other site 768486003909 Cytokine receptor motif; other site 768486003910 chitin-binding domain of Chi A1-like proteins; Region: ChiA1_BD; cd12214 768486003911 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 768486003912 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 768486003913 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 768486003914 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 768486003915 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 768486003916 active site 768486003917 tetramer interface; other site 768486003918 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 768486003919 Predicted membrane protein [Function unknown]; Region: COG1288; cl17886 768486003920 hypothetical protein; Provisional; Region: PRK11588 768486003921 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 768486003922 isoaspartyl dipeptidase; Provisional; Region: PRK10657 768486003923 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 768486003924 active site 768486003925 CsbD-like; Region: CsbD; cl17424 768486003926 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 768486003927 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 768486003928 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 768486003929 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 768486003930 putative deacylase active site [active] 768486003931 metal-dependent hydrolase; Provisional; Region: PRK00685 768486003932 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 768486003933 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 768486003934 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 768486003935 DNA-binding site [nucleotide binding]; DNA binding site 768486003936 DRTGG domain; Region: DRTGG; pfam07085 768486003937 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 768486003938 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 768486003939 active site 2 [active] 768486003940 active site 1 [active] 768486003941 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 768486003942 DHH family; Region: DHH; pfam01368 768486003943 DHHA1 domain; Region: DHHA1; pfam02272 768486003944 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 768486003945 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 768486003946 PhnA protein; Region: PhnA; pfam03831 768486003947 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298 768486003948 potential frameshift: common BLAST hit: gi|383329554|ref|YP_005355438.1| M protein trans-acting positive regulator 768486003949 Mga helix-turn-helix domain; Region: Mga; pfam05043 768486003950 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 768486003951 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 768486003952 nucleoside/Zn binding site; other site 768486003953 dimer interface [polypeptide binding]; other site 768486003954 catalytic motif [active] 768486003955 Holin family; Region: Phage_holin_4; cl01989 768486003956 Bacteriophage peptidoglycan hydrolase; Region: Amidase_5; pfam05382 768486003957 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 768486003958 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 768486003959 active site 768486003960 metal binding site [ion binding]; metal-binding site 768486003961 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 768486003962 Protein of unknown function (DUF1027); Region: DUF1027; pfam06265 768486003963 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 768486003964 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 768486003965 active site 768486003966 motif I; other site 768486003967 motif II; other site 768486003968 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 768486003969 Protein of unknown function (DUF1461); Region: DUF1461; pfam07314 768486003970 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 768486003971 tetramer interfaces [polypeptide binding]; other site 768486003972 binuclear metal-binding site [ion binding]; other site 768486003973 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 768486003974 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 768486003975 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 768486003976 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 768486003977 active site 768486003978 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 768486003979 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 768486003980 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768486003981 homodimer interface [polypeptide binding]; other site 768486003982 catalytic residue [active] 768486003983 Predicted RNA binding protein (contains ribosomal protein S1 domain) [Translation, ribosomal structure and biogenesis]; Region: VacB; COG1098 768486003984 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 768486003985 RNA binding site [nucleotide binding]; other site 768486003986 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4918 768486003987 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 768486003988 trimer interface [polypeptide binding]; other site 768486003989 active site 768486003990 G bulge; other site 768486003991 Phosphotransferase enzyme family; Region: APH; pfam01636 768486003992 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 768486003993 active site 768486003994 ATP binding site [chemical binding]; other site 768486003995 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 768486003996 substrate binding site [chemical binding]; other site 768486003997 Acyl-ACP thioesterase; Region: Acyl-ACP_TE; pfam01643 768486003998 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 768486003999 active site 768486004000 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 768486004001 active site 768486004002 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 768486004003 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 768486004004 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 768486004005 active site 768486004006 homotetramer interface [polypeptide binding]; other site 768486004007 homodimer interface [polypeptide binding]; other site 768486004008 Protein of unknown function DUF72; Region: DUF72; pfam01904 768486004009 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 768486004010 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 768486004011 active site 768486004012 motif I; other site 768486004013 motif II; other site 768486004014 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 768486004015 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4696 768486004016 metal binding site [ion binding]; metal-binding site 768486004017 Septation ring formation regulator, EzrA; Region: EzrA; pfam06160 768486004018 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 768486004019 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 768486004020 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 768486004021 catalytic residue [active] 768486004022 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 768486004023 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 768486004024 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 768486004025 Ligand Binding Site [chemical binding]; other site 768486004026 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 768486004027 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 768486004028 CoA binding domain; Region: CoA_binding; pfam02629 768486004029 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 768486004030 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 768486004031 active site 768486004032 HIGH motif; other site 768486004033 nucleotide binding site [chemical binding]; other site 768486004034 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 768486004035 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 768486004036 active site 768486004037 KMSKS motif; other site 768486004038 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 768486004039 tRNA binding surface [nucleotide binding]; other site 768486004040 anticodon binding site; other site 768486004041 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 768486004042 folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499 768486004043 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 768486004044 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 768486004045 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 768486004046 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 768486004047 motif II; other site 768486004048 hypothetical protein; Reviewed; Region: PRK00024 768486004049 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 768486004050 MPN+ (JAMM) motif; other site 768486004051 Zinc-binding site [ion binding]; other site 768486004052 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 768486004053 DNA-binding site [nucleotide binding]; DNA binding site 768486004054 RNA-binding motif; other site 768486004055 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 768486004056 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 768486004057 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 768486004058 Protein of unknown function (DUF1447); Region: DUF1447; pfam07288 768486004059 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 768486004060 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 768486004061 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768486004062 Walker A/P-loop; other site 768486004063 ATP binding site [chemical binding]; other site 768486004064 Q-loop/lid; other site 768486004065 ABC transporter signature motif; other site 768486004066 Walker B; other site 768486004067 D-loop; other site 768486004068 H-loop/switch region; other site 768486004069 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 768486004070 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 768486004071 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 768486004072 Walker A/P-loop; other site 768486004073 ATP binding site [chemical binding]; other site 768486004074 Q-loop/lid; other site 768486004075 ABC transporter signature motif; other site 768486004076 Walker B; other site 768486004077 D-loop; other site 768486004078 H-loop/switch region; other site 768486004079 legume lectins; Region: lectin_L-type; cl14058 768486004080 homotetramer interaction site [polypeptide binding]; other site 768486004081 homodimer interaction site [polypeptide binding]; other site 768486004082 carbohydrate binding site [chemical binding]; other site 768486004083 metal binding site [ion binding]; metal-binding site 768486004084 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 768486004085 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 768486004086 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 768486004087 trimer interface [polypeptide binding]; other site 768486004088 putative metal binding site [ion binding]; other site 768486004089 Clp protease; Region: CLP_protease; pfam00574 768486004090 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 768486004091 oligomer interface [polypeptide binding]; other site 768486004092 active site residues [active] 768486004093 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 768486004094 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 768486004095 active site 768486004096 catalytic site [active] 768486004097 metal binding site [ion binding]; metal-binding site 768486004098 dimer interface [polypeptide binding]; other site 768486004099 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 768486004100 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 768486004101 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 768486004102 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 768486004103 HflX GTPase family; Region: HflX; cd01878 768486004104 G1 box; other site 768486004105 GTP/Mg2+ binding site [chemical binding]; other site 768486004106 Switch I region; other site 768486004107 G2 box; other site 768486004108 G3 box; other site 768486004109 Switch II region; other site 768486004110 G4 box; other site 768486004111 G5 box; other site 768486004112 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 768486004113 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 768486004114 DNA binding residues [nucleotide binding] 768486004115 putative dimer interface [polypeptide binding]; other site 768486004116 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 768486004117 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 768486004118 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 768486004119 CTP synthetase; Validated; Region: pyrG; PRK05380 768486004120 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 768486004121 Catalytic site [active] 768486004122 active site 768486004123 UTP binding site [chemical binding]; other site 768486004124 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 768486004125 active site 768486004126 putative oxyanion hole; other site 768486004127 catalytic triad [active] 768486004128 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 768486004129 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 768486004130 intersubunit interface [polypeptide binding]; other site 768486004131 active site 768486004132 zinc binding site [ion binding]; other site 768486004133 Na+ binding site [ion binding]; other site 768486004134 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 768486004135 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 768486004136 hinge; other site 768486004137 active site 768486004138 transcription termination factor Rho; Provisional; Region: rho; PRK09376 768486004139 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 768486004140 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 768486004141 RNA binding site [nucleotide binding]; other site 768486004142 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 768486004143 Walker A motif; other site 768486004144 ATP binding site [chemical binding]; other site 768486004145 Walker B motif; other site 768486004146 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 768486004147 4-hydroxyphenylpyruvate dioxygenase; Region: PLN02875 768486004148 Peptidase M60-like family; Region: M60-like; pfam13402 768486004149 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 768486004150 aromatic chitin/cellulose binding site residues [chemical binding]; other site 768486004151 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 768486004152 active site 768486004153 phosphorylation site [posttranslational modification] 768486004154 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 768486004155 active site 768486004156 P-loop; other site 768486004157 phosphorylation site [posttranslational modification] 768486004158 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 768486004159 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 768486004160 intersubunit interface [polypeptide binding]; other site 768486004161 active site 768486004162 zinc binding site [ion binding]; other site 768486004163 Na+ binding site [ion binding]; other site 768486004164 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 768486004165 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 768486004166 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 768486004167 Endo-beta-N-acetylglucosaminidase D [Carbohydrate transport and metabolism]; Region: COG4724 768486004168 Endo-beta-N-acetylglucosaminidase (ENGase) hydrolyzes the N-N'-diacetylchitobiosyl core of N-glycosylproteins. The beta-1,4-glycosyl bond located between two N-acetylglucosamine residues is hydrolyzed such that N-acetylglucosamine 1 remains with...; Region: GH85_ENGase; cd06547 768486004169 putative active site [active] 768486004170 FOG: PKD repeat [General function prediction only]; Region: COG3291 768486004171 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 768486004172 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 768486004173 sugar binding site [chemical binding]; other site 768486004174 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768486004175 Major Facilitator Superfamily; Region: MFS_1; pfam07690 768486004176 putative substrate translocation pore; other site 768486004177 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 768486004178 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 768486004179 ligand binding site [chemical binding]; other site 768486004180 flexible hinge region; other site 768486004181 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 768486004182 non-specific DNA interactions [nucleotide binding]; other site 768486004183 DNA binding site [nucleotide binding] 768486004184 sequence specific DNA binding site [nucleotide binding]; other site 768486004185 putative cAMP binding site [chemical binding]; other site 768486004186 Repair protein; Region: Repair_PSII; pfam04536 768486004187 Membrane protease subunit, stomatin/prohibitin family [Amino acid transport and metabolism]; Region: COG4260 768486004188 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_5; cd03408 768486004189 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 768486004190 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 768486004191 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768486004192 Walker A motif; other site 768486004193 ATP binding site [chemical binding]; other site 768486004194 Walker B motif; other site 768486004195 arginine finger; other site 768486004196 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 768486004197 hypothetical protein; Validated; Region: PRK00153 768486004198 recombination protein RecR; Reviewed; Region: recR; PRK00076 768486004199 RecR protein; Region: RecR; pfam02132 768486004200 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 768486004201 putative active site [active] 768486004202 putative metal-binding site [ion binding]; other site 768486004203 tetramer interface [polypeptide binding]; other site 768486004204 thymidylate kinase; Validated; Region: tmk; PRK00698 768486004205 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 768486004206 TMP-binding site; other site 768486004207 ATP-binding site [chemical binding]; other site 768486004208 Protein of unknown function (DUF970); Region: DUF970; cl17525 768486004209 DNA polymerase III subunit delta'; Validated; Region: PRK08058 768486004210 DNA polymerase III subunit delta'; Validated; Region: PRK08485 768486004211 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 768486004212 Protein of unknown function (DUF972); Region: DUF972; pfam06156 768486004213 Predicted methyltransferases [General function prediction only]; Region: COG0313 768486004214 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 768486004215 putative SAM binding site [chemical binding]; other site 768486004216 putative homodimer interface [polypeptide binding]; other site 768486004217 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 768486004218 catalytic residues [active] 768486004219 Predicted permeases [General function prediction only]; Region: COG0701 768486004220 Predicted membrane protein [Function unknown]; Region: COG3689 768486004221 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 768486004222 Uncharacterized conserved protein [Function unknown]; Region: COG2966 768486004223 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 768486004224 potential protein location (hypothetical protein EHR_08035 [Enterococcus hirae ATCC 9790]) that overlaps RNA (tRNA-G) 768486004225 potential frameshift: common BLAST hit: gi|258539355|ref|YP_003173854.1| DNA-entry nuclease 768486004226 hypothetical protein; Provisional; Region: PRK05473 768486004227 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 768486004228 hypothetical protein; Provisional; Region: PRK13678 768486004229 RNA polymerase sigma factor, SigM family; Region: SigM_subfam; TIGR02950 768486004230 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 768486004231 DNA binding residues [nucleotide binding] 768486004232 Sigma factor regulator N-terminal; Region: Sigma_reg_N; pfam13800 768486004233 Sigma factor regulator C-terminal; Region: Sigma_reg_C; pfam13791 768486004234 SEFIR domain; Region: SEFIR; pfam08357 768486004235 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768486004236 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 768486004237 Coenzyme A binding pocket [chemical binding]; other site 768486004238 malate dehydrogenase; Provisional; Region: PRK13529 768486004239 Malic enzyme, N-terminal domain; Region: malic; pfam00390 768486004240 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 768486004241 NAD(P) binding site [chemical binding]; other site 768486004242 2-hydroxycarboxylate transporter family; Region: 2HCT; pfam03390 768486004243 Protein of unknown function (DUF1310); Region: DUF1310; pfam07006 768486004244 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 768486004245 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 768486004246 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 768486004247 DNA-binding site [nucleotide binding]; DNA binding site 768486004248 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 768486004249 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768486004250 homodimer interface [polypeptide binding]; other site 768486004251 catalytic residue [active] 768486004252 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 768486004253 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 768486004254 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 768486004255 L-lactate oxidase; Region: L_lactate_ox; TIGR02708 768486004256 L-Lactate oxidase (LOX) FMN-binding domain. LOX is a member of the family of FMN-containing alpha-hydroxyacid oxidases and catalyzes the oxidation of l-lactate using molecular oxygen to generate pyruvate and H2O2. This family occurs in both prokaryotes...; Region: LOX_like_FMN; cd04737 768486004257 teramer interface [polypeptide binding]; other site 768486004258 active site 768486004259 FMN binding site [chemical binding]; other site 768486004260 catalytic residues [active] 768486004261 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 768486004262 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 768486004263 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 768486004264 Walker A/P-loop; other site 768486004265 ATP binding site [chemical binding]; other site 768486004266 ABC transporter; Region: ABC_tran; pfam00005 768486004267 Q-loop/lid; other site 768486004268 ABC transporter signature motif; other site 768486004269 Walker B; other site 768486004270 D-loop; other site 768486004271 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 768486004272 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 768486004273 potential frameshift: common BLAST hit: gi|217965793|ref|YP_002351471.1| chitinase B 768486004274 ribonuclease HIII; Provisional; Region: PRK00996 768486004275 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 768486004276 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 768486004277 RNA/DNA hybrid binding site [nucleotide binding]; other site 768486004278 active site 768486004279 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 768486004280 Colicin V production protein; Region: Colicin_V; pfam02674 768486004281 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 768486004282 MutS domain III; Region: MutS_III; pfam05192 768486004283 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768486004284 Walker A/P-loop; other site 768486004285 ATP binding site [chemical binding]; other site 768486004286 Q-loop/lid; other site 768486004287 ABC transporter signature motif; other site 768486004288 Walker B; other site 768486004289 D-loop; other site 768486004290 H-loop/switch region; other site 768486004291 Smr domain; Region: Smr; pfam01713 768486004292 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 768486004293 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 768486004294 catalytic residues [active] 768486004295 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 768486004296 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 768486004297 GIY-YIG motif/motif A; other site 768486004298 active site 768486004299 catalytic site [active] 768486004300 putative DNA binding site [nucleotide binding]; other site 768486004301 metal binding site [ion binding]; metal-binding site 768486004302 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 768486004303 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 768486004304 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 768486004305 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768486004306 Walker A/P-loop; other site 768486004307 ATP binding site [chemical binding]; other site 768486004308 Q-loop/lid; other site 768486004309 ABC transporter signature motif; other site 768486004310 Walker B; other site 768486004311 D-loop; other site 768486004312 H-loop/switch region; other site 768486004313 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 768486004314 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 768486004315 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 768486004316 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 768486004317 catalytic triad [active] 768486004318 V-type ATPase 116kDa subunit family; Region: V_ATPase_I; pfam01496 768486004319 V-type ATP synthase subunit K; Validated; Region: PRK06558 768486004320 ATP synthase subunit C; Region: ATP-synt_C; pfam00137 768486004321 ATP synthase subunit C; Region: ATP-synt_C; pfam00137 768486004322 Archaeal/vacuolar-type H+-ATPase subunit E [Energy production and conversion]; Region: NtpE; COG1390 768486004323 Archaeal/vacuolar-type H+-ATPase subunit C [Energy production and conversion]; Region: NtpC; COG1527 768486004324 V-type ATP synthase subunit C; Provisional; Region: PRK01198; cl00660 768486004325 V-type ATP synthase subunit F; Provisional; Region: PRK01395 768486004326 V-type ATP synthase subunit A; Provisional; Region: PRK04192 768486004327 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 768486004328 V/A-type ATP synthase catalytic subunit A. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_A; cd01134 768486004329 Walker A motif/ATP binding site; other site 768486004330 Walker B motif; other site 768486004331 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 768486004332 V-type ATP synthase subunit B; Provisional; Region: PRK04196 768486004333 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 768486004334 V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_B; cd01135 768486004335 Walker A motif homologous position; other site 768486004336 Walker B motif; other site 768486004337 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 768486004338 V-type ATP synthase subunit D; Reviewed; Region: PRK00373 768486004339 Cation transport protein; Region: TrkH; cl17365 768486004340 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 768486004341 Cation transport protein; Region: TrkH; pfam02386 768486004342 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 768486004343 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 768486004344 dimer interface [polypeptide binding]; other site 768486004345 active site 768486004346 metal binding site [ion binding]; metal-binding site 768486004347 glutathione binding site [chemical binding]; other site 768486004348 Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684 768486004349 nudix motif; other site 768486004350 sugar phosphate phosphatase; Provisional; Region: PRK10513 768486004351 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 768486004352 active site 768486004353 motif I; other site 768486004354 motif II; other site 768486004355 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 768486004356 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 768486004357 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 768486004358 Zn2+ binding site [ion binding]; other site 768486004359 Mg2+ binding site [ion binding]; other site 768486004360 potential frameshift: common BLAST hit: gi|389869260|ref|YP_006376683.1| lipoate--protein ligase A 768486004361 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 768486004362 Domain of unknown function (DUF1934); Region: DUF1934; pfam09148 768486004363 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066 768486004364 RNA polymerase sigma-70 factor, TIGR02954 family; Region: Sig70_famx3 768486004365 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 768486004366 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 768486004367 DNA binding residues [nucleotide binding] 768486004368 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 768486004369 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 768486004370 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 768486004371 DNA-binding site [nucleotide binding]; DNA binding site 768486004372 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 768486004373 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 768486004374 dipeptidase, putative; Region: dipeptidaselike; TIGR01887 768486004375 active site 768486004376 metal binding site [ion binding]; metal-binding site 768486004377 Glycosylasparaginase catalyzes the hydrolysis of the glycosylamide bond of asparagine-linked glycoproteins. This enzyme is an amidase located inside lysosomes. Mutation of this gene in humans causes a genetic disorder known as aspartylglycosaminuria (AGU)...; Region: Glycosylasparaginase; cd04513 768486004378 active site 768486004379 dimer interface [polypeptide binding]; other site 768486004380 catalytic nucleophile [active] 768486004381 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 768486004382 active site 768486004383 P-loop; other site 768486004384 phosphorylation site [posttranslational modification] 768486004385 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 768486004386 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 768486004387 glycine reductase, selenoprotein B; Region: gly_red_sel_B; TIGR01917 768486004388 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 768486004389 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 768486004390 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 768486004391 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 768486004392 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 768486004393 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 768486004394 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 768486004395 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 768486004396 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 768486004397 Phosphoglycerate kinase; Region: PGK; pfam00162 768486004398 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 768486004399 substrate binding site [chemical binding]; other site 768486004400 hinge regions; other site 768486004401 ADP binding site [chemical binding]; other site 768486004402 catalytic site [active] 768486004403 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 768486004404 triosephosphate isomerase; Provisional; Region: PRK14565 768486004405 substrate binding site [chemical binding]; other site 768486004406 dimer interface [polypeptide binding]; other site 768486004407 catalytic triad [active] 768486004408 enolase; Provisional; Region: eno; PRK00077 768486004409 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 768486004410 dimer interface [polypeptide binding]; other site 768486004411 metal binding site [ion binding]; metal-binding site 768486004412 substrate binding pocket [chemical binding]; other site 768486004413 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 768486004414 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 768486004415 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588 768486004416 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 768486004417 metal binding site [ion binding]; metal-binding site 768486004418 dimer interface [polypeptide binding]; other site 768486004419 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 768486004420 NH_3: A subgroup of nucleoside hydrolases. This group contains eukaryotic and bacterial proteins similar to nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes...; Region: nuc_hydro_3; cd02653 768486004421 active site 768486004422 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 768486004423 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 768486004424 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768486004425 Coenzyme A binding pocket [chemical binding]; other site 768486004426 Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314 768486004427 Esterase/lipase [General function prediction only]; Region: COG1647 768486004428 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 768486004429 ribonuclease R; Region: RNase_R; TIGR02063 768486004430 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 768486004431 RNB domain; Region: RNB; pfam00773 768486004432 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 768486004433 RNA binding site [nucleotide binding]; other site 768486004434 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 768486004435 SmpB-tmRNA interface; other site 768486004436 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 768486004437 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 768486004438 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 768486004439 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 768486004440 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 768486004441 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 768486004442 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 768486004443 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 768486004444 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 768486004445 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 768486004446 beta subunit interaction interface [polypeptide binding]; other site 768486004447 Walker A motif; other site 768486004448 ATP binding site [chemical binding]; other site 768486004449 Walker B motif; other site 768486004450 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 768486004451 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 768486004452 core domain interface [polypeptide binding]; other site 768486004453 delta subunit interface [polypeptide binding]; other site 768486004454 epsilon subunit interface [polypeptide binding]; other site 768486004455 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 768486004456 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 768486004457 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 768486004458 alpha subunit interaction interface [polypeptide binding]; other site 768486004459 Walker A motif; other site 768486004460 ATP binding site [chemical binding]; other site 768486004461 Walker B motif; other site 768486004462 inhibitor binding site; inhibition site 768486004463 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 768486004464 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 768486004465 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 768486004466 gamma subunit interface [polypeptide binding]; other site 768486004467 epsilon subunit interface [polypeptide binding]; other site 768486004468 LBP interface [polypeptide binding]; other site 768486004469 transport-energizing ATPase, TRC40/GET3/ArsA family; Region: GET3_arsA_TRC40; TIGR00345 768486004470 Protein of unknown function (DUF1146); Region: DUF1146; cl11486 768486004471 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 768486004472 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 768486004473 hinge; other site 768486004474 active site 768486004475 DNA-directed RNA polymerase subunit beta; Region: EpuA; pfam11772 768486004476 Haemolytic domain; Region: Haemolytic; pfam01809 768486004477 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768486004478 Coenzyme A binding pocket [chemical binding]; other site 768486004479 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 768486004480 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 768486004481 nucleotide binding site [chemical binding]; other site 768486004482 Protein of unknown function (DUF2969); Region: DUF2969; pfam11184 768486004483 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 768486004484 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 768486004485 DNA-binding site [nucleotide binding]; DNA binding site 768486004486 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 768486004487 Uncharacterized conserved protein [Function unknown]; Region: COG1739 768486004488 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 768486004489 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 768486004490 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 768486004491 active site 768486004492 P-loop; other site 768486004493 phosphorylation site [posttranslational modification] 768486004494 potential frameshift: common BLAST hit: gi|332686409|ref|YP_004456183.1| DNA transporter ATPase 768486004495 comF family protein; Region: comF; TIGR00201 768486004496 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 768486004497 active site 768486004498 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 768486004499 30S subunit binding site; other site 768486004500 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 768486004501 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 768486004502 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 768486004503 nucleotide binding region [chemical binding]; other site 768486004504 ATP-binding site [chemical binding]; other site 768486004505 SEC-C motif; Region: SEC-C; pfam02810 768486004506 peptide chain release factor 2; Provisional; Region: PRK05589 768486004507 This domain is found in peptide chain release factors; Region: PCRF; smart00937 768486004508 RF-1 domain; Region: RF-1; pfam00472 768486004509 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 768486004510 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768486004511 Walker A/P-loop; other site 768486004512 ATP binding site [chemical binding]; other site 768486004513 Q-loop/lid; other site 768486004514 ABC transporter signature motif; other site 768486004515 Walker B; other site 768486004516 D-loop; other site 768486004517 H-loop/switch region; other site 768486004518 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 768486004519 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 768486004520 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 768486004521 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 768486004522 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 768486004523 putative active site [active] 768486004524 catalytic site [active] 768486004525 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 768486004526 putative active site [active] 768486004527 catalytic site [active] 768486004528 phosphate binding protein; Region: ptsS_2; TIGR02136 768486004529 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 768486004530 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 768486004531 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768486004532 dimer interface [polypeptide binding]; other site 768486004533 conserved gate region; other site 768486004534 putative PBP binding loops; other site 768486004535 ABC-ATPase subunit interface; other site 768486004536 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 768486004537 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768486004538 dimer interface [polypeptide binding]; other site 768486004539 conserved gate region; other site 768486004540 putative PBP binding loops; other site 768486004541 ABC-ATPase subunit interface; other site 768486004542 phosphate transporter ATP-binding protein; Provisional; Region: PRK14237 768486004543 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 768486004544 Walker A/P-loop; other site 768486004545 ATP binding site [chemical binding]; other site 768486004546 Q-loop/lid; other site 768486004547 ABC transporter signature motif; other site 768486004548 Walker B; other site 768486004549 D-loop; other site 768486004550 H-loop/switch region; other site 768486004551 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 768486004552 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 768486004553 Walker A/P-loop; other site 768486004554 ATP binding site [chemical binding]; other site 768486004555 Q-loop/lid; other site 768486004556 ABC transporter signature motif; other site 768486004557 Walker B; other site 768486004558 D-loop; other site 768486004559 H-loop/switch region; other site 768486004560 potential frameshift: common BLAST hit: gi|29376303|ref|NP_815457.1| PhoU family protein 768486004561 Uncharacterized conserved protein [Function unknown]; Region: COG3595 768486004562 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 768486004563 PspC domain; Region: PspC; pfam04024 768486004564 Membrane protein of unknown function; Region: DUF360; pfam04020 768486004565 HPr kinase/phosphorylase; Provisional; Region: PRK05428 768486004566 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 768486004567 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 768486004568 Hpr binding site; other site 768486004569 active site 768486004570 homohexamer subunit interaction site [polypeptide binding]; other site 768486004571 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 768486004572 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 768486004573 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 768486004574 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 768486004575 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 768486004576 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 768486004577 active site 768486004578 tetramer interface; other site 768486004579 Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768 768486004580 YtxH-like protein; Region: YtxH; pfam12732 768486004581 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 768486004582 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 768486004583 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 768486004584 active site 768486004585 catabolite control protein A; Region: ccpA; TIGR01481 768486004586 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 768486004587 DNA binding site [nucleotide binding] 768486004588 domain linker motif; other site 768486004589 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 768486004590 dimerization interface [polypeptide binding]; other site 768486004591 effector binding site; other site 768486004592 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 768486004593 Transglycosylase; Region: Transgly; pfam00912 768486004594 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 768486004595 endonuclease IV; Provisional; Region: PRK01060 768486004596 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 768486004597 AP (apurinic/apyrimidinic) site pocket; other site 768486004598 DNA interaction; other site 768486004599 Metal-binding active site; metal-binding site 768486004600 manganese transport protein MntH; Reviewed; Region: PRK00701 768486004601 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 768486004602 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3763 768486004603 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 768486004604 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 768486004605 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768486004606 Walker A/P-loop; other site 768486004607 ATP binding site [chemical binding]; other site 768486004608 Q-loop/lid; other site 768486004609 ABC transporter signature motif; other site 768486004610 Walker B; other site 768486004611 D-loop; other site 768486004612 H-loop/switch region; other site 768486004613 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 768486004614 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 768486004615 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768486004616 Walker A/P-loop; other site 768486004617 ATP binding site [chemical binding]; other site 768486004618 Q-loop/lid; other site 768486004619 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 768486004620 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 768486004621 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 768486004622 putative active site [active] 768486004623 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 768486004624 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 768486004625 NAD binding site [chemical binding]; other site 768486004626 sugar binding site [chemical binding]; other site 768486004627 divalent metal binding site [ion binding]; other site 768486004628 tetramer (dimer of dimers) interface [polypeptide binding]; other site 768486004629 dimer interface [polypeptide binding]; other site 768486004630 6-phospho-beta-glucosidase; Reviewed; Region: arb; PRK09593 768486004631 beta-galactosidase; Region: BGL; TIGR03356 768486004632 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 768486004633 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 768486004634 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 768486004635 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 768486004636 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 768486004637 active site 768486004638 substrate binding site [chemical binding]; other site 768486004639 metal binding site [ion binding]; metal-binding site 768486004640 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 768486004641 dimerization interface [polypeptide binding]; other site 768486004642 putative DNA binding site [nucleotide binding]; other site 768486004643 putative Zn2+ binding site [ion binding]; other site 768486004644 Kinase/pyrophosphorylase; Region: Kinase-PPPase; pfam03618 768486004645 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 768486004646 metal binding site 2 [ion binding]; metal-binding site 768486004647 putative DNA binding helix; other site 768486004648 metal binding site 1 [ion binding]; metal-binding site 768486004649 dimer interface [polypeptide binding]; other site 768486004650 structural Zn2+ binding site [ion binding]; other site 768486004651 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 768486004652 Yqey-like protein; Region: YqeY; pfam09424 768486004653 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 768486004654 PhoH-like protein; Region: PhoH; pfam02562 768486004655 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 768486004656 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768486004657 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 768486004658 Zn2+ binding site [ion binding]; other site 768486004659 Mg2+ binding site [ion binding]; other site 768486004660 metal-binding heat shock protein; Provisional; Region: PRK00016 768486004661 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 768486004662 GTPase Era; Reviewed; Region: era; PRK00089 768486004663 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 768486004664 G1 box; other site 768486004665 GTP/Mg2+ binding site [chemical binding]; other site 768486004666 Switch I region; other site 768486004667 G2 box; other site 768486004668 Switch II region; other site 768486004669 G3 box; other site 768486004670 G4 box; other site 768486004671 G5 box; other site 768486004672 KH domain; Region: KH_2; pfam07650 768486004673 Recombination protein O N terminal; Region: RecO_N; pfam11967 768486004674 DNA repair protein RecO; Region: reco; TIGR00613 768486004675 Recombination protein O C terminal; Region: RecO_C; pfam02565 768486004676 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 768486004677 dimer interface [polypeptide binding]; other site 768486004678 motif 1; other site 768486004679 active site 768486004680 motif 2; other site 768486004681 motif 3; other site 768486004682 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 768486004683 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 768486004684 Chain length determinant protein; Region: Wzz; cl15801 768486004685 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 768486004686 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 768486004687 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 768486004688 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 768486004689 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 768486004690 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 768486004691 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 768486004692 NAD(P) binding site [chemical binding]; other site 768486004693 homodimer interface [polypeptide binding]; other site 768486004694 substrate binding site [chemical binding]; other site 768486004695 active site 768486004696 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 768486004697 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 768486004698 putative trimer interface [polypeptide binding]; other site 768486004699 putative CoA binding site [chemical binding]; other site 768486004700 aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181 768486004701 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 768486004702 inhibitor-cofactor binding pocket; inhibition site 768486004703 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768486004704 catalytic residue [active] 768486004705 Bacterial sugar transferase; Region: Bac_transf; pfam02397 768486004706 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 768486004707 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 768486004708 putative ADP-binding pocket [chemical binding]; other site 768486004709 UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057 768486004710 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 768486004711 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 768486004712 potential frameshift: common BLAST hit: gi|328957721|ref|YP_004375107.1| putative teichoic acid/polysaccharide export protein 768486004713 OxaA-like protein precursor; Provisional; Region: PRK02463 768486004714 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 768486004715 Acylphosphatases [Energy production and conversion]; Region: AcyP; COG1254 768486004716 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 768486004717 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 768486004718 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 768486004719 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 768486004720 Zn2+ binding site [ion binding]; other site 768486004721 Mg2+ binding site [ion binding]; other site 768486004722 Fibronectin-binding protein (FBP); Region: FBP; pfam07299 768486004723 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 768486004724 ClC sycA-like chloride channel proteins. This ClC family presents in bacteria, where it facilitates acid resistance in acidic soil. Mutation of this gene (sycA) in Rhizobium tropici CIAT899 causes serious deficiencies in nodule development, nodulation...; Region: ClC_sycA_like; cd03682 768486004725 putative Cl- selectivity filter; other site 768486004726 putative pore gating glutamate residue; other site 768486004727 Uncharacterized conserved protein [Function unknown]; Region: COG1434 768486004728 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 768486004729 putative active site [active] 768486004730 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 768486004731 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 768486004732 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 768486004733 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 768486004734 DNA-binding site [nucleotide binding]; DNA binding site 768486004735 RNA-binding motif; other site 768486004736 potential frameshift: common BLAST hit: gi|29376872|ref|NP_816026.1| DNA polymerase III, epsilon subunit/ATP-dependent helicase DinG 768486004737 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 768486004738 aspartate aminotransferase; Provisional; Region: PRK05764 768486004739 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 768486004740 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768486004741 homodimer interface [polypeptide binding]; other site 768486004742 catalytic residue [active] 768486004743 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 768486004744 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 768486004745 putative dimer interface [polypeptide binding]; other site 768486004746 putative anticodon binding site; other site 768486004747 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 768486004748 homodimer interface [polypeptide binding]; other site 768486004749 motif 1; other site 768486004750 motif 2; other site 768486004751 active site 768486004752 motif 3; other site 768486004753 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 768486004754 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 768486004755 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 768486004756 metal-binding site [ion binding] 768486004757 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 768486004758 Soluble P-type ATPase [General function prediction only]; Region: COG4087 768486004759 Amino acid permease; Region: AA_permease_2; pfam13520 768486004760 topology modulation protein; Reviewed; Region: PRK08118 768486004761 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cd02019 768486004762 active site 768486004763 copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698 768486004764 Penicillinase repressor; Region: Pencillinase_R; pfam03965 768486004765 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 768486004766 metal-binding site [ion binding] 768486004767 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 768486004768 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 768486004769 metal-binding site [ion binding] 768486004770 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 768486004771 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 768486004772 motif II; other site 768486004773 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 768486004774 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 768486004775 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 768486004776 motif II; other site 768486004777 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 768486004778 PBP superfamily domain; Region: PBP_like_2; cl17296 768486004779 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 768486004780 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 768486004781 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 768486004782 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 768486004783 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 768486004784 motif II; other site 768486004785 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 768486004786 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 768486004787 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 768486004788 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 768486004789 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768486004790 dimer interface [polypeptide binding]; other site 768486004791 phosphorylation site [posttranslational modification] 768486004792 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768486004793 ATP binding site [chemical binding]; other site 768486004794 Mg2+ binding site [ion binding]; other site 768486004795 G-X-G motif; other site 768486004796 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 768486004797 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768486004798 active site 768486004799 phosphorylation site [posttranslational modification] 768486004800 intermolecular recognition site; other site 768486004801 dimerization interface [polypeptide binding]; other site 768486004802 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 768486004803 DNA binding site [nucleotide binding] 768486004804 Protein of unknown function (DUF523); Region: DUF523; pfam04463 768486004805 putative DNA-binding protein; Validated; Region: PRK00118 768486004806 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 768486004807 signal recognition particle protein; Provisional; Region: PRK10867 768486004808 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 768486004809 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 768486004810 P loop; other site 768486004811 GTP binding site [chemical binding]; other site 768486004812 Signal peptide binding domain; Region: SRP_SPB; pfam02978 768486004813 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 768486004814 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 768486004815 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl17426 768486004816 NADP+ binding site [chemical binding]; other site 768486004817 Predicted flavoprotein [General function prediction only]; Region: COG0431 768486004818 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 768486004819 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 768486004820 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 768486004821 Walker A/P-loop; other site 768486004822 ATP binding site [chemical binding]; other site 768486004823 Q-loop/lid; other site 768486004824 ABC transporter signature motif; other site 768486004825 Walker B; other site 768486004826 D-loop; other site 768486004827 H-loop/switch region; other site 768486004828 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 768486004829 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 768486004830 KH domain; Region: KH_4; pfam13083 768486004831 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 768486004832 RimM N-terminal domain; Region: RimM; pfam01782 768486004833 PRC-barrel domain; Region: PRC; pfam05239 768486004834 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 768486004835 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 768486004836 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 768486004837 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 768486004838 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 768486004839 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 768486004840 DNA-binding site [nucleotide binding]; DNA binding site 768486004841 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 768486004842 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 768486004843 beta-galactosidase; Region: BGL; TIGR03356 768486004844 Histidine kinase-like ATPases; Region: HATPase_c; smart00387 768486004845 G-X-G motif; other site 768486004846 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 768486004847 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768486004848 active site 768486004849 phosphorylation site [posttranslational modification] 768486004850 intermolecular recognition site; other site 768486004851 dimerization interface [polypeptide binding]; other site 768486004852 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 768486004853 DNA binding site [nucleotide binding] 768486004854 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 768486004855 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 768486004856 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 768486004857 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 768486004858 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 768486004859 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 768486004860 potential frameshift: common BLAST hit: gi|281491818|ref|YP_003353798.1| PepP/PepQ-like peptidase 768486004861 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 768486004862 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 768486004863 DNA binding residues [nucleotide binding] 768486004864 putative dimer interface [polypeptide binding]; other site 768486004865 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 768486004866 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 768486004867 homodimer interface [polypeptide binding]; other site 768486004868 substrate-cofactor binding pocket; other site 768486004869 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768486004870 catalytic residue [active] 768486004871 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 768486004872 homotrimer interaction site [polypeptide binding]; other site 768486004873 putative active site [active] 768486004874 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 768486004875 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 768486004876 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 768486004877 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 768486004878 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 768486004879 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 768486004880 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 768486004881 YheO-like PAS domain; Region: PAS_6; pfam08348 768486004882 HTH domain; Region: HTH_22; pfam13309 768486004883 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 768486004884 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768486004885 Coenzyme A binding pocket [chemical binding]; other site 768486004886 potential frameshift: common BLAST hit: gi|29375786|ref|NP_814940.1| acetolactate synthase 768486004887 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306 768486004888 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 768486004889 potential frameshift: common BLAST hit: gi|383329203|ref|YP_005355087.1| IS1251-like transposase 768486004890 Transposase; Region: DDE_Tnp_ISL3; pfam01610 768486004891 Transcriptional regulators [Transcription]; Region: MarR; COG1846 768486004892 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 768486004893 putative DNA binding site [nucleotide binding]; other site 768486004894 putative Zn2+ binding site [ion binding]; other site 768486004895 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 768486004896 dimer interface [polypeptide binding]; other site 768486004897 FMN binding site [chemical binding]; other site 768486004898 Uncharacterized conserved protein [Function unknown]; Region: COG1359 768486004899 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 768486004900 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 768486004901 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 768486004902 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 768486004903 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915 768486004904 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 768486004905 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 768486004906 Int/Topo IB signature motif; other site 768486004907 Predicted membrane protein [Function unknown]; Region: XynA; COG2314 768486004908 Domain of unknown function (DUF955); Region: DUF955; pfam06114 768486004909 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 768486004910 non-specific DNA binding site [nucleotide binding]; other site 768486004911 salt bridge; other site 768486004912 sequence-specific DNA binding site [nucleotide binding]; other site 768486004913 Helix-turn-helix domain; Region: HTH_17; cl17695 768486004914 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 768486004915 ORF6C domain; Region: ORF6C; pfam10552 768486004916 Protein of unknown function (DUF1071); Region: DUF1071; pfam06378 768486004917 Protein of unknown function (DUF968); Region: DUF968; pfam06147 768486004918 N-terminal phage replisome organiser (Phage_rep_org_N); Region: Phage_rep_org_N; pfam09681 768486004919 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768486004920 Walker A motif; other site 768486004921 ATP binding site [chemical binding]; other site 768486004922 Walker B motif; other site 768486004923 arginine finger; other site 768486004924 Protein of unknown function (DUF1064); Region: DUF1064; pfam06356 768486004925 Protein of unknown function (DUF1140); Region: DUF1140; pfam06600 768486004926 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u3; cd11540 768486004927 putative metal binding site [ion binding]; other site 768486004928 DNA repair and recombination protein RadA; Validated; Region: radA; PRK04301 768486004929 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 768486004930 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 768486004931 active site 768486004932 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 768486004933 Phage portal protein; Region: Phage_portal; pfam04860 768486004934 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 768486004935 oligomer interface [polypeptide binding]; other site 768486004936 active site residues [active] 768486004937 Phage capsid family; Region: Phage_capsid; pfam05065 768486004938 Phage-related minor tail protein [Function unknown]; Region: COG5280 768486004939 membrane protein P6; Region: PHA01399 768486004940 Phage-related protein [Function unknown]; Region: COG4722 768486004941 Phage tail protein; Region: Sipho_tail; cl17486 768486004942 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 768486004943 Hepatic lectin, N-terminal domain; Region: Lectin_N; pfam03954 768486004944 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 768486004945 amidase catalytic site [active] 768486004946 Zn binding residues [ion binding]; other site 768486004947 substrate binding site [chemical binding]; other site 768486004948 Abi-like protein; Region: Abi_2; cl01988 768486004949 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 768486004950 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 768486004951 SdpI/YhfL protein family; Region: SdpI; pfam13630 768486004952 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 768486004953 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768486004954 active site 768486004955 phosphorylation site [posttranslational modification] 768486004956 intermolecular recognition site; other site 768486004957 dimerization interface [polypeptide binding]; other site 768486004958 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 768486004959 DNA binding site [nucleotide binding] 768486004960 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 768486004961 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 768486004962 dimerization interface [polypeptide binding]; other site 768486004963 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768486004964 dimer interface [polypeptide binding]; other site 768486004965 phosphorylation site [posttranslational modification] 768486004966 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768486004967 ATP binding site [chemical binding]; other site 768486004968 Mg2+ binding site [ion binding]; other site 768486004969 G-X-G motif; other site 768486004970 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 768486004971 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 768486004972 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 768486004973 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 768486004974 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 768486004975 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 768486004976 Sulfatase; Region: Sulfatase; pfam00884 768486004977 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 768486004978 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 768486004979 putative RNA binding site [nucleotide binding]; other site 768486004980 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768486004981 S-adenosylmethionine binding site [chemical binding]; other site 768486004982 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 768486004983 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 768486004984 active site 768486004985 catalytic residue [active] 768486004986 dimer interface [polypeptide binding]; other site 768486004987 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 768486004988 putative deacylase active site [active] 768486004989 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 768486004990 HI0933-like protein; Region: HI0933_like; pfam03486 768486004991 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 768486004992 potential frameshift: common BLAST hit: gi|29375982|ref|NP_815136.1| glutamate dehydrogenase 768486004993 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 768486004994 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 768486004995 active site 768486004996 dimer interface [polypeptide binding]; other site 768486004997 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 768486004998 dimer interface [polypeptide binding]; other site 768486004999 active site 768486005000 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 768486005001 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 768486005002 Int/Topo IB signature motif; other site 768486005003 SIR2-like domain; Region: SIR2_2; pfam13289 768486005004 Short C-terminal domain; Region: SHOCT; pfam09851 768486005005 Domain of unknown function (DUF955); Region: DUF955; pfam06114 768486005006 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 768486005007 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 768486005008 non-specific DNA binding site [nucleotide binding]; other site 768486005009 salt bridge; other site 768486005010 sequence-specific DNA binding site [nucleotide binding]; other site 768486005011 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 768486005012 non-specific DNA binding site [nucleotide binding]; other site 768486005013 salt bridge; other site 768486005014 sequence-specific DNA binding site [nucleotide binding]; other site 768486005015 Protein of unknown function (Hypoth_ymh); Region: Hypoth_Ymh; pfam09509 768486005016 Protein of unknown function (DUF1064); Region: DUF1064; pfam06356 768486005017 Protein of unknown function (DUF3955); Region: DUF3955; pfam13127 768486005018 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 768486005019 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 768486005020 Domain of unknown function (DUF2479); Region: DUF2479; pfam10651 768486005021 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 768486005022 amidase catalytic site [active] 768486005023 Zn binding residues [ion binding]; other site 768486005024 substrate binding site [chemical binding]; other site 768486005025 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 768486005026 DNA-binding site [nucleotide binding]; DNA binding site 768486005027 RNA-binding motif; other site 768486005028 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 768486005029 Glycerophosphodiester phosphodiesterase domain of Agrobacterium tumefaciens and similar proteins; Region: GDPD_AtGDE_like; cd08566 768486005030 putative active site [active] 768486005031 catalytic site [active] 768486005032 putative metal binding site [ion binding]; other site 768486005033 oligomer interface [polypeptide binding]; other site 768486005034 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 768486005035 amidase catalytic site [active] 768486005036 Zn binding residues [ion binding]; other site 768486005037 substrate binding site [chemical binding]; other site 768486005038 Protein of unknown function (DUF4231); Region: DUF4231; pfam14015 768486005039 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 768486005040 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 768486005041 active site 768486005042 Uncharacterized conserved protein [Function unknown]; Region: COG1359 768486005043 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 768486005044 Protein of unknown function (DUF4231); Region: DUF4231; pfam14015 768486005045 potential frameshift: common BLAST hit: gi|29376432|ref|NP_815586.1| glycerophosphoryl diester phosphodiesterase family protein 768486005046 potential frameshift: common BLAST hit: gi|29376432|ref|NP_815586.1| glycerophosphoryl diester phosphodiesterase family protein 768486005047 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 768486005048 Uncharacterized conserved protein [Function unknown]; Region: COG0398 768486005049 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 768486005050 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 768486005051 WHG domain; Region: WHG; pfam13305 768486005052 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 768486005053 Putative Catalytic site; other site 768486005054 DXD motif; other site 768486005055 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 768486005056 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 768486005057 active site 768486005058 dimer interface [polypeptide binding]; other site 768486005059 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 768486005060 Ligand Binding Site [chemical binding]; other site 768486005061 Molecular Tunnel; other site 768486005062 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4876 768486005063 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 768486005064 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 768486005065 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 768486005066 folate binding site [chemical binding]; other site 768486005067 NADP+ binding site [chemical binding]; other site 768486005068 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 768486005069 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 768486005070 putative ligand binding residues [chemical binding]; other site 768486005071 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 768486005072 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 768486005073 Walker A/P-loop; other site 768486005074 ATP binding site [chemical binding]; other site 768486005075 Q-loop/lid; other site 768486005076 ABC transporter signature motif; other site 768486005077 Walker B; other site 768486005078 D-loop; other site 768486005079 H-loop/switch region; other site 768486005080 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 768486005081 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 768486005082 ABC-ATPase subunit interface; other site 768486005083 dimer interface [polypeptide binding]; other site 768486005084 putative PBP binding regions; other site 768486005085 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 768486005086 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 768486005087 ABC-ATPase subunit interface; other site 768486005088 dimer interface [polypeptide binding]; other site 768486005089 putative PBP binding regions; other site 768486005090 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 768486005091 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 768486005092 Rhomboid family; Region: Rhomboid; pfam01694 768486005093 Bacterial protein of unknown function (DUF910); Region: DUF910; pfam06014 768486005094 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 768486005095 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 768486005096 nucleotide binding site [chemical binding]; other site 768486005097 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 768486005098 active site residue [active] 768486005099 Uncharacterized conserved protein [Function unknown]; Region: COG3189 768486005100 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 768486005101 Protein of unknown function (DUF3042); Region: DUF3042; pfam11240 768486005102 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 768486005103 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 768486005104 NAD binding site [chemical binding]; other site 768486005105 homodimer interface [polypeptide binding]; other site 768486005106 active site 768486005107 substrate binding site [chemical binding]; other site 768486005108 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 768486005109 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 768486005110 Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744 768486005111 Transcriptional regulators [Transcription]; Region: PurR; COG1609 768486005112 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 768486005113 DNA binding site [nucleotide binding] 768486005114 domain linker motif; other site 768486005115 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 768486005116 putative dimerization interface [polypeptide binding]; other site 768486005117 putative ligand binding site [chemical binding]; other site 768486005118 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 768486005119 Glycoprotease family; Region: Peptidase_M22; pfam00814 768486005120 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 768486005121 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768486005122 Coenzyme A binding pocket [chemical binding]; other site 768486005123 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 768486005124 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768486005125 Coenzyme A binding pocket [chemical binding]; other site 768486005126 UGMP family protein; Validated; Region: PRK09604 768486005127 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 768486005128 nucleotide binding site [chemical binding]; other site 768486005129 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098 768486005130 active site 768486005131 catalytic site [active] 768486005132 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 768486005133 Chain length determinant protein; Region: Wzz; cl15801 768486005134 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 768486005135 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 768486005136 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 768486005137 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 768486005138 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 768486005139 NAD(P) binding site [chemical binding]; other site 768486005140 homodimer interface [polypeptide binding]; other site 768486005141 substrate binding site [chemical binding]; other site 768486005142 active site 768486005143 O-Antigen ligase; Region: Wzy_C; pfam04932 768486005144 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 768486005145 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 768486005146 active site 768486005147 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 768486005148 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 768486005149 ligand binding site [chemical binding]; other site 768486005150 flexible hinge region; other site 768486005151 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 768486005152 arginine deiminase; Provisional; Region: PRK01388 768486005153 ornithine carbamoyltransferase; Validated; Region: PRK02102 768486005154 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 768486005155 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 768486005156 carbamate kinase; Reviewed; Region: PRK12686 768486005157 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 768486005158 putative substrate binding site [chemical binding]; other site 768486005159 nucleotide binding site [chemical binding]; other site 768486005160 nucleotide binding site [chemical binding]; other site 768486005161 homodimer interface [polypeptide binding]; other site 768486005162 arginyl-tRNA synthetase; Reviewed; Region: PRK12451 768486005163 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 768486005164 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 768486005165 active site 768486005166 HIGH motif; other site 768486005167 KMSK motif region; other site 768486005168 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 768486005169 tRNA binding surface [nucleotide binding]; other site 768486005170 anticodon binding site; other site 768486005171 Arginine repressor [Transcription]; Region: ArgR; COG1438 768486005172 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 768486005173 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 768486005174 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 768486005175 rRNA interaction site [nucleotide binding]; other site 768486005176 S8 interaction site; other site 768486005177 putative laminin-1 binding site; other site 768486005178 elongation factor Ts; Provisional; Region: tsf; PRK09377 768486005179 UBA/TS-N domain; Region: UBA; pfam00627 768486005180 Elongation factor TS; Region: EF_TS; pfam00889 768486005181 Elongation factor TS; Region: EF_TS; pfam00889 768486005182 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 768486005183 putative nucleotide binding site [chemical binding]; other site 768486005184 uridine monophosphate binding site [chemical binding]; other site 768486005185 homohexameric interface [polypeptide binding]; other site 768486005186 ribosome recycling factor; Reviewed; Region: frr; PRK00083 768486005187 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 768486005188 hinge region; other site 768486005189 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 768486005190 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 768486005191 catalytic residue [active] 768486005192 putative FPP diphosphate binding site; other site 768486005193 putative FPP binding hydrophobic cleft; other site 768486005194 dimer interface [polypeptide binding]; other site 768486005195 putative IPP diphosphate binding site; other site 768486005196 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 768486005197 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 768486005198 RIP metalloprotease RseP; Region: TIGR00054 768486005199 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 768486005200 active site 768486005201 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 768486005202 protein binding site [polypeptide binding]; other site 768486005203 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 768486005204 putative substrate binding region [chemical binding]; other site 768486005205 prolyl-tRNA synthetase; Provisional; Region: PRK09194 768486005206 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 768486005207 dimer interface [polypeptide binding]; other site 768486005208 motif 1; other site 768486005209 active site 768486005210 motif 2; other site 768486005211 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 768486005212 putative deacylase active site [active] 768486005213 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 768486005214 active site 768486005215 motif 3; other site 768486005216 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 768486005217 anticodon binding site; other site 768486005218 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 768486005219 classical (c) SDRs; Region: SDR_c; cd05233 768486005220 NAD(P) binding site [chemical binding]; other site 768486005221 active site 768486005222 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 768486005223 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 768486005224 active site 768486005225 catalytic tetrad [active] 768486005226 Predicted transcriptional regulators [Transcription]; Region: COG1733 768486005227 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 768486005228 dimerization interface [polypeptide binding]; other site 768486005229 putative Zn2+ binding site [ion binding]; other site 768486005230 putative DNA binding site [nucleotide binding]; other site 768486005231 potential frameshift: common BLAST hit: gi|29376875|ref|NP_816029.1| DNA polymerase III PolC 768486005232 ribosome maturation protein RimP; Reviewed; Region: PRK00092 768486005233 Sm and related proteins; Region: Sm_like; cl00259 768486005234 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 768486005235 putative oligomer interface [polypeptide binding]; other site 768486005236 putative RNA binding site [nucleotide binding]; other site 768486005237 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 768486005238 NusA N-terminal domain; Region: NusA_N; pfam08529 768486005239 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 768486005240 RNA binding site [nucleotide binding]; other site 768486005241 homodimer interface [polypeptide binding]; other site 768486005242 NusA-like KH domain; Region: KH_5; pfam13184 768486005243 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 768486005244 G-X-X-G motif; other site 768486005245 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 768486005246 putative RNA binding cleft [nucleotide binding]; other site 768486005247 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 768486005248 potential frameshift: common BLAST hit: gi|29375843|ref|NP_814997.1| translation initiation factor IF-2 768486005249 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 768486005250 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01550 768486005251 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 768486005252 RNA binding site [nucleotide binding]; other site 768486005253 active site 768486005254 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 768486005255 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 768486005256 active site 768486005257 Riboflavin kinase; Region: Flavokinase; pfam01687 768486005258 glucose-1-dehydrogenase; Provisional; Region: PRK08936 768486005259 glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358 768486005260 NAD binding site [chemical binding]; other site 768486005261 homodimer interface [polypeptide binding]; other site 768486005262 active site 768486005263 Helix-turn-helix domain; Region: HTH_17; pfam12728 768486005264 putative heme d1 biosynthesis radical SAM protein NirJ2; Region: rSAM_NirJ2; TIGR04055 768486005265 putative heme d1 biosynthesis radical SAM protein NirJ2; Region: rSAM_NirJ2; TIGR04055 768486005266 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 768486005267 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 768486005268 WxL domain surface cell wall-binding; Region: WxL; pfam13731 768486005269 WxL domain surface cell wall-binding; Region: WxL; pfam13731 768486005270 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 768486005271 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 768486005272 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 768486005273 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 768486005274 LytTr DNA-binding domain; Region: LytTR; pfam04397 768486005275 Histidine kinase; Region: His_kinase; pfam06580 768486005276 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 768486005277 Mg2+ binding site [ion binding]; other site 768486005278 G-X-G motif; other site 768486005279 Response regulator receiver domain; Region: Response_reg; pfam00072 768486005280 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768486005281 active site 768486005282 phosphorylation site [posttranslational modification] 768486005283 intermolecular recognition site; other site 768486005284 dimerization interface [polypeptide binding]; other site 768486005285 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 768486005286 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768486005287 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 768486005288 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768486005289 dimer interface [polypeptide binding]; other site 768486005290 conserved gate region; other site 768486005291 ABC-ATPase subunit interface; other site 768486005292 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 768486005293 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768486005294 dimer interface [polypeptide binding]; other site 768486005295 conserved gate region; other site 768486005296 putative PBP binding loops; other site 768486005297 ABC-ATPase subunit interface; other site 768486005298 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 768486005299 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 768486005300 Domain of unknown function (DUF3502); Region: DUF3502; pfam12010 768486005301 N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789 768486005302 active site 768486005303 catalytic site [active] 768486005304 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; pfam09261 768486005305 Glycosyl hydrolases family 38 C-terminal domain; Region: Glyco_hydro_38C; pfam07748 768486005306 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 768486005307 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 768486005308 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 768486005309 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 768486005310 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 768486005311 Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119 768486005312 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 768486005313 Glycosyl hydrolase family 20 (GH20) catalytic domain of dispersin B (DspB), lacto-N-biosidase (LnbB) and related proteins. Dispersin B is a soluble beta-N-acetylglucosamidase found in bacteria that hydrolyzes the beta-1,6-linkages of PGA (poly-beta-(1,6)...; Region: GH20_DspB_LnbB-like; cd06564 768486005314 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 768486005315 active site 768486005316 hypothetical protein; Provisional; Region: PRK11770 768486005317 Domain of unknown function (DUF307); Region: DUF307; pfam03733 768486005318 Predicted transcriptional regulators [Transcription]; Region: COG1695 768486005319 Transcriptional regulator PadR-like family; Region: PadR; cl17335 768486005320 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768486005321 Major Facilitator Superfamily; Region: MFS_1; pfam07690 768486005322 putative substrate translocation pore; other site 768486005323 Restriction endonuclease; Region: Mrr_cat; pfam04471 768486005324 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 768486005325 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 768486005326 FeS/SAM binding site; other site 768486005327 HemN C-terminal domain; Region: HemN_C; pfam06969 768486005328 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 768486005329 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 768486005330 GrpE; Region: GrpE; pfam01025 768486005331 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 768486005332 dimer interface [polypeptide binding]; other site 768486005333 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 768486005334 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 768486005335 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 768486005336 nucleotide binding site [chemical binding]; other site 768486005337 NEF interaction site [polypeptide binding]; other site 768486005338 SBD interface [polypeptide binding]; other site 768486005339 chaperone protein DnaJ; Provisional; Region: PRK14276 768486005340 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 768486005341 HSP70 interaction site [polypeptide binding]; other site 768486005342 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 768486005343 substrate binding site [polypeptide binding]; other site 768486005344 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 768486005345 Zn binding sites [ion binding]; other site 768486005346 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 768486005347 dimer interface [polypeptide binding]; other site 768486005348 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 768486005349 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 768486005350 Walker A/P-loop; other site 768486005351 ATP binding site [chemical binding]; other site 768486005352 Q-loop/lid; other site 768486005353 ABC transporter signature motif; other site 768486005354 Walker B; other site 768486005355 D-loop; other site 768486005356 H-loop/switch region; other site 768486005357 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 768486005358 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 768486005359 substrate binding pocket [chemical binding]; other site 768486005360 membrane-bound complex binding site; other site 768486005361 hinge residues; other site 768486005362 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768486005363 dimer interface [polypeptide binding]; other site 768486005364 conserved gate region; other site 768486005365 ABC-ATPase subunit interface; other site 768486005366 excinuclease ABC subunit B; Provisional; Region: PRK05298 768486005367 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 768486005368 ATP binding site [chemical binding]; other site 768486005369 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 768486005370 nucleotide binding region [chemical binding]; other site 768486005371 ATP-binding site [chemical binding]; other site 768486005372 Ultra-violet resistance protein B; Region: UvrB; pfam12344 768486005373 UvrB/uvrC motif; Region: UVR; pfam02151 768486005374 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 768486005375 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 768486005376 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 768486005377 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 768486005378 Predicted ATP-grasp enzyme [General function prediction only]; Region: COG3919 768486005379 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 768486005380 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 768486005381 aspartate racemase; Region: asp_race; TIGR00035 768486005382 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 768486005383 AAA domain; Region: AAA_18; pfam13238 768486005384 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 768486005385 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 768486005386 phosphate binding site [ion binding]; other site 768486005387 putative substrate binding pocket [chemical binding]; other site 768486005388 dimer interface [polypeptide binding]; other site 768486005389 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 768486005390 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 768486005391 Thioredoxin; Region: Thioredoxin_4; pfam13462 768486005392 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 768486005393 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 768486005394 dimer interface [polypeptide binding]; other site 768486005395 PYR/PP interface [polypeptide binding]; other site 768486005396 TPP binding site [chemical binding]; other site 768486005397 substrate binding site [chemical binding]; other site 768486005398 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 768486005399 Domain of unknown function; Region: EKR; pfam10371 768486005400 4Fe-4S binding domain; Region: Fer4_6; pfam12837 768486005401 4Fe-4S binding domain; Region: Fer4; pfam00037 768486005402 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 768486005403 TPP-binding site [chemical binding]; other site 768486005404 dimer interface [polypeptide binding]; other site 768486005405 Uncharacterized conserved protein [Function unknown]; Region: COG1624 768486005406 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 768486005407 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 768486005408 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 768486005409 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 768486005410 active site 768486005411 substrate binding site [chemical binding]; other site 768486005412 metal binding site [ion binding]; metal-binding site 768486005413 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 768486005414 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 768486005415 Interdomain contacts; other site 768486005416 Cytokine receptor motif; other site 768486005417 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 768486005418 Interdomain contacts; other site 768486005419 Cytokine receptor motif; other site 768486005420 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 768486005421 Interdomain contacts; other site 768486005422 Cytokine receptor motif; other site 768486005423 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 768486005424 Interdomain contacts; other site 768486005425 Cytokine receptor motif; other site 768486005426 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 768486005427 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 768486005428 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 768486005429 glutaminase active site [active] 768486005430 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 768486005431 dimer interface [polypeptide binding]; other site 768486005432 active site 768486005433 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 768486005434 dimer interface [polypeptide binding]; other site 768486005435 active site 768486005436 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 768486005437 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 768486005438 tandem repeat interface [polypeptide binding]; other site 768486005439 oligomer interface [polypeptide binding]; other site 768486005440 active site residues [active] 768486005441 RDD family; Region: RDD; pfam06271 768486005442 trigger factor; Provisional; Region: tig; PRK01490 768486005443 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 768486005444 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 768486005445 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 768486005446 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 768486005447 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768486005448 Walker A motif; other site 768486005449 ATP binding site [chemical binding]; other site 768486005450 Walker B motif; other site 768486005451 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 768486005452 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 768486005453 G1 box; other site 768486005454 GTP/Mg2+ binding site [chemical binding]; other site 768486005455 Switch I region; other site 768486005456 G2 box; other site 768486005457 G3 box; other site 768486005458 Switch II region; other site 768486005459 G4 box; other site 768486005460 G5 box; other site 768486005461 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 768486005462 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 768486005463 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 768486005464 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 768486005465 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 768486005466 putative substrate binding site [chemical binding]; other site 768486005467 putative ATP binding site [chemical binding]; other site 768486005468 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 768486005469 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 768486005470 active site 768486005471 phosphorylation site [posttranslational modification] 768486005472 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 768486005473 active site 768486005474 P-loop; other site 768486005475 phosphorylation site [posttranslational modification] 768486005476 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 768486005477 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 768486005478 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 768486005479 Cl- selectivity filter; other site 768486005480 Cl- binding residues [ion binding]; other site 768486005481 pore gating glutamate residue; other site 768486005482 dimer interface [polypeptide binding]; other site 768486005483 H+/Cl- coupling transport residue; other site 768486005484 TrkA-C domain; Region: TrkA_C; pfam02080 768486005485 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 768486005486 Part of AAA domain; Region: AAA_19; pfam13245 768486005487 Family description; Region: UvrD_C_2; pfam13538 768486005488 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 768486005489 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 768486005490 nucleotide binding pocket [chemical binding]; other site 768486005491 K-X-D-G motif; other site 768486005492 catalytic site [active] 768486005493 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 768486005494 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 768486005495 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 768486005496 Dimer interface [polypeptide binding]; other site 768486005497 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 768486005498 potential frameshift: common BLAST hit: gi|29375321|ref|NP_814475.1| glutamyl-tRNA(Gln) amidotransferase, A subunit 768486005499 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 768486005500 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 768486005501 GatB domain; Region: GatB_Yqey; smart00845 768486005502 putative lipid kinase; Reviewed; Region: PRK13055 768486005503 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 768486005504 TRAM domain; Region: TRAM; cl01282 768486005505 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 768486005506 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768486005507 S-adenosylmethionine binding site [chemical binding]; other site 768486005508 Mga helix-turn-helix domain; Region: Mga; pfam05043 768486005509 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 768486005510 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 768486005511 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 768486005512 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 768486005513 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 768486005514 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 768486005515 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 768486005516 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 768486005517 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 768486005518 potential frameshift: common BLAST hit: gi|389869712|ref|YP_006377135.1| glycosyl hydrolase 768486005519 BNR repeat-like domain; Region: BNR_2; pfam13088 768486005520 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 768486005521 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 768486005522 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768486005523 Walker A/P-loop; other site 768486005524 ATP binding site [chemical binding]; other site 768486005525 Q-loop/lid; other site 768486005526 ABC transporter signature motif; other site 768486005527 Walker B; other site 768486005528 D-loop; other site 768486005529 H-loop/switch region; other site 768486005530 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 768486005531 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 768486005532 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768486005533 Walker A/P-loop; other site 768486005534 ATP binding site [chemical binding]; other site 768486005535 Q-loop/lid; other site 768486005536 ABC transporter signature motif; other site 768486005537 Walker B; other site 768486005538 D-loop; other site 768486005539 H-loop/switch region; other site 768486005540 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 768486005541 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 768486005542 DNA binding residues [nucleotide binding] 768486005543 dimer interface [polypeptide binding]; other site 768486005544 Transcriptional regulators [Transcription]; Region: PurR; COG1609 768486005545 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 768486005546 DNA binding site [nucleotide binding] 768486005547 domain linker motif; other site 768486005548 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 768486005549 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 768486005550 Melibiase; Region: Melibiase; pfam02065 768486005551 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 768486005552 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 768486005553 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 768486005554 potential frameshift: common BLAST hit: gi|338203848|ref|YP_004649993.1| beta-galactosidase small subunit 768486005555 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 768486005556 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 768486005557 Histidine kinase; Region: His_kinase; pfam06580 768486005558 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 768486005559 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 768486005560 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768486005561 active site 768486005562 phosphorylation site [posttranslational modification] 768486005563 intermolecular recognition site; other site 768486005564 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768486005565 potential frameshift: common BLAST hit: gi|332686484|ref|YP_004456258.1| alpha-arabinosides ABC transporter permease AraN 768486005566 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768486005567 dimer interface [polypeptide binding]; other site 768486005568 conserved gate region; other site 768486005569 putative PBP binding loops; other site 768486005570 ABC-ATPase subunit interface; other site 768486005571 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 768486005572 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768486005573 dimer interface [polypeptide binding]; other site 768486005574 conserved gate region; other site 768486005575 putative PBP binding loops; other site 768486005576 ABC-ATPase subunit interface; other site 768486005577 Viral enhancin protein; Region: Enhancin; pfam03272 768486005578 Peptidase M60-like family; Region: M60-like; pfam13402 768486005579 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 768486005580 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 768486005581 YSIRK-targeted surface antigen transcriptional regulator; Region: adjacent_YSIRK; TIGR04094 768486005582 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 768486005583 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 768486005584 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 768486005585 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 768486005586 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 768486005587 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 768486005588 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 768486005589 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 768486005590 beta-galactosidase; Region: BGL; TIGR03356 768486005591 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 768486005592 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 768486005593 Domain of unknown function (DUF4091); Region: DUF4091; pfam13320 768486005594 Protein of unknown function (DUF1538); Region: DUF1538; pfam07556 768486005595 Protein of unknown function (DUF1538); Region: DUF1538; pfam07556 768486005596 Nitrogen regulatory protein P-II; Region: P-II; smart00938 768486005597 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 768486005598 catalytic core [active] 768486005599 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 768486005600 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 768486005601 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 768486005602 motif II; other site 768486005603 Protein of unknown function (DUF1149); Region: DUF1149; cl11551 768486005604 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 768486005605 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 768486005606 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 768486005607 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 768486005608 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 768486005609 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 768486005610 active site residue [active] 768486005611 Protein of unknown function (DUF3650); Region: DUF3650; pfam12368 768486005612 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 768486005613 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 768486005614 active site 768486005615 metal binding site [ion binding]; metal-binding site 768486005616 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 768486005617 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 768486005618 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 768486005619 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 768486005620 RNA binding site [nucleotide binding]; other site 768486005621 SprT homologues; Region: SprT; cl01182 768486005622 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 768486005623 putative active site [active] 768486005624 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 768486005625 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 768486005626 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 768486005627 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 768486005628 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 768486005629 active site 2 [active] 768486005630 active site 1 [active] 768486005631 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 768486005632 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 768486005633 potential frameshift: common BLAST hit: gi|29375463|ref|NP_814617.1| DNA polymerase I 768486005634 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 768486005635 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 768486005636 DNA binding site [nucleotide binding] 768486005637 catalytic residue [active] 768486005638 H2TH interface [polypeptide binding]; other site 768486005639 putative catalytic residues [active] 768486005640 turnover-facilitating residue; other site 768486005641 intercalation triad [nucleotide binding]; other site 768486005642 8OG recognition residue [nucleotide binding]; other site 768486005643 putative reading head residues; other site 768486005644 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 768486005645 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 768486005646 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 768486005647 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 768486005648 CoA-binding site [chemical binding]; other site 768486005649 ATP-binding [chemical binding]; other site 768486005650 potential frameshift: common BLAST hit: gi|29375466|ref|NP_814620.1| transcriptional regulator NrdR 768486005651 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 768486005652 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 768486005653 potential frameshift: common BLAST hit: gi|29375468|ref|NP_814622.1| primosomal protein DnaI 768486005654 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 768486005655 Family of unknown function (DUF633); Region: DUF633; pfam04816 768486005656 Uncharacterized conserved protein [Function unknown]; Region: COG0327 768486005657 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 768486005658 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 768486005659 Uncharacterized conserved protein [Function unknown]; Region: COG0327 768486005660 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 768486005661 peptidase T; Region: peptidase-T; TIGR01882 768486005662 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 768486005663 metal binding site [ion binding]; metal-binding site 768486005664 dimer interface [polypeptide binding]; other site 768486005665 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 768486005666 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 768486005667 Protein of unknown function (DUF1294); Region: DUF1294; pfam06961 768486005668 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 768486005669 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 768486005670 Clp amino terminal domain; Region: Clp_N; pfam02861 768486005671 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768486005672 Walker A motif; other site 768486005673 ATP binding site [chemical binding]; other site 768486005674 Walker B motif; other site 768486005675 arginine finger; other site 768486005676 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768486005677 Walker A motif; other site 768486005678 ATP binding site [chemical binding]; other site 768486005679 Walker B motif; other site 768486005680 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 768486005681 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014 768486005682 hypothetical protein; Provisional; Region: PRK01346 768486005683 Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527 768486005684 Sterol carrier protein domain; Region: SCP2_2; pfam13530 768486005685 GTP-binding protein LepA; Provisional; Region: PRK05433 768486005686 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 768486005687 G1 box; other site 768486005688 putative GEF interaction site [polypeptide binding]; other site 768486005689 GTP/Mg2+ binding site [chemical binding]; other site 768486005690 Switch I region; other site 768486005691 G2 box; other site 768486005692 G3 box; other site 768486005693 Switch II region; other site 768486005694 G4 box; other site 768486005695 G5 box; other site 768486005696 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 768486005697 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 768486005698 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 768486005699 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 768486005700 DNA-binding site [nucleotide binding]; DNA binding site 768486005701 RNA-binding motif; other site 768486005702 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 768486005703 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768486005704 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 768486005705 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 768486005706 Uncharacterized conserved protein [Function unknown]; Region: COG3589 768486005707 Uncharacterized conserved protein [Function unknown]; Region: COG3589 768486005708 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 768486005709 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 768486005710 nucleotide binding site [chemical binding]; other site 768486005711 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 768486005712 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 768486005713 S-formylglutathione hydrolase; Region: PLN02442 768486005714 Putative esterase; Region: Esterase; pfam00756 768486005715 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 768486005716 beta-galactosidase; Region: BGL; TIGR03356 768486005717 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 768486005718 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 768486005719 nucleotide binding site [chemical binding]; other site 768486005720 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 768486005721 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 768486005722 DNA-binding site [nucleotide binding]; DNA binding site 768486005723 RNA-binding motif; other site 768486005724 conserved hypothetical protein; Region: TIGR02328 768486005725 Pyrimidine dimer DNA glycosylase; Region: Pyr_excise; pfam03013 768486005726 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 768486005727 sequence-specific DNA binding site [nucleotide binding]; other site 768486005728 salt bridge; other site 768486005729 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 768486005730 catalytic triad [active] 768486005731 conserved cis-peptide bond; other site 768486005732 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 768486005733 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 768486005734 active site 768486005735 motif I; other site 768486005736 motif II; other site 768486005737 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 768486005738 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 768486005739 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 768486005740 Ligand binding site; other site 768486005741 metal-binding site 768486005742 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 768486005743 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 768486005744 Ligand binding site; other site 768486005745 metal-binding site 768486005746 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 768486005747 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 768486005748 Cl binding site [ion binding]; other site 768486005749 oligomer interface [polypeptide binding]; other site 768486005750 oxidoreductase; Provisional; Region: PRK07985 768486005751 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768486005752 NAD(P) binding site [chemical binding]; other site 768486005753 active site 768486005754 Small integral membrane protein (DUF2273); Region: DUF2273; cl11575 768486005755 Asp23 family; Region: Asp23; pfam03780 768486005756 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 768486005757 Rib/alpha-like repeat; Region: Rib; cl07159 768486005758 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 768486005759 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 768486005760 salt bridge; other site 768486005761 non-specific DNA binding site [nucleotide binding]; other site 768486005762 sequence-specific DNA binding site [nucleotide binding]; other site 768486005763 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 768486005764 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 768486005765 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 768486005766 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768486005767 active site 768486005768 phosphorylation site [posttranslational modification] 768486005769 intermolecular recognition site; other site 768486005770 dimerization interface [polypeptide binding]; other site 768486005771 LytTr DNA-binding domain; Region: LytTR; pfam04397 768486005772 Accessory gene regulator B; Region: AgrB; pfam04647 768486005773 Staphylococcal AgrD protein; Region: AgrD; cl05477 768486005774 Small integral membrane protein (DUF2273); Region: DUF2273; cl11575 768486005775 Asp23 family; Region: Asp23; pfam03780 768486005776 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 768486005777 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 768486005778 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 768486005779 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 768486005780 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 768486005781 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK12315 768486005782 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 768486005783 TPP-binding site; other site 768486005784 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 768486005785 PYR/PP interface [polypeptide binding]; other site 768486005786 dimer interface [polypeptide binding]; other site 768486005787 TPP binding site [chemical binding]; other site 768486005788 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 768486005789 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 768486005790 putative deacylase active site [active] 768486005791 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 768486005792 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 768486005793 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 768486005794 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 768486005795 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 768486005796 Cell cycle protein; Region: FTSW_RODA_SPOVE; pfam01098 768486005797 Transcriptional regulator [Transcription]; Region: LytR; COG1316 768486005798 Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976 768486005799 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 768486005800 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 768486005801 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 768486005802 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768486005803 Major Facilitator Superfamily; Region: MFS_1; pfam07690 768486005804 putative substrate translocation pore; other site 768486005805 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 768486005806 MarR family; Region: MarR; pfam01047 768486005807 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 768486005808 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 768486005809 Short repeat of unknown function (DUF308); Region: DUF308; pfam03729 768486005810 Uncharacterized protein conserved in bacteria (DUF2200); Region: DUF2200; pfam09966 768486005811 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 768486005812 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 768486005813 catalytic residue [active] 768486005814 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 768486005815 catalytic residues [active] 768486005816 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 768486005817 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 768486005818 peroxiredoxin; Region: AhpC; TIGR03137 768486005819 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 768486005820 dimer interface [polypeptide binding]; other site 768486005821 decamer (pentamer of dimers) interface [polypeptide binding]; other site 768486005822 catalytic triad [active] 768486005823 peroxidatic and resolving cysteines [active] 768486005824 potential frameshift: common BLAST hit: gi|389868630|ref|YP_006376053.1| transcriptional regulator 768486005825 Protein of unknown function (DUF2552); Region: DUF2552; pfam10827 768486005826 Mga helix-turn-helix domain; Region: Mga; pfam05043 768486005827 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 768486005828 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 768486005829 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 768486005830 active site 768486005831 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 768486005832 MarR family; Region: MarR; pfam01047 768486005833 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 768486005834 Uncharacterized conserved protein [Function unknown]; Region: COG1284 768486005835 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 768486005836 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 768486005837 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 768486005838 CoenzymeA binding site [chemical binding]; other site 768486005839 subunit interaction site [polypeptide binding]; other site 768486005840 PHB binding site; other site 768486005841 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 768486005842 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 768486005843 substrate binding site [chemical binding]; other site 768486005844 oxyanion hole (OAH) forming residues; other site 768486005845 trimer interface [polypeptide binding]; other site 768486005846 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK03640 768486005847 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 768486005848 acyl-activating enzyme (AAE) consensus motif; other site 768486005849 putative AMP binding site [chemical binding]; other site 768486005850 putative active site [active] 768486005851 putative CoA binding site [chemical binding]; other site 768486005852 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 768486005853 chorismate binding enzyme; Region: Chorismate_bind; cl10555 768486005854 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 768486005855 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 768486005856 dimer interface [polypeptide binding]; other site 768486005857 tetramer interface [polypeptide binding]; other site 768486005858 PYR/PP interface [polypeptide binding]; other site 768486005859 TPP binding site [chemical binding]; other site 768486005860 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 768486005861 TPP-binding site; other site 768486005862 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 768486005863 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 768486005864 N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317 768486005865 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 768486005866 active site 768486005867 octamer interface [polypeptide binding]; other site 768486005868 maltodextrin glucosidase; Provisional; Region: PRK10785 768486005869 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 768486005870 homodimer interface [polypeptide binding]; other site 768486005871 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 768486005872 active site 768486005873 homodimer interface [polypeptide binding]; other site 768486005874 catalytic site [active] 768486005875 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 768486005876 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 768486005877 potential frameshift: common BLAST hit: gi|116873560|ref|YP_850341.1| maltose/maltodextrin ABC transporter, permease protein 768486005878 potential frameshift: common BLAST hit: gi|328957685|ref|YP_004375071.1| maltodextrin ABC transport system 768486005879 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 768486005880 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768486005881 dimer interface [polypeptide binding]; other site 768486005882 conserved gate region; other site 768486005883 putative PBP binding loops; other site 768486005884 ABC-ATPase subunit interface; other site 768486005885 Predicted integral membrane protein [Function unknown]; Region: COG5521 768486005886 Predicted integral membrane protein [Function unknown]; Region: COG5521 768486005887 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 768486005888 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768486005889 S-adenosylmethionine binding site [chemical binding]; other site 768486005890 RnfC Barrel sandwich hybrid domain; Region: RnfC_N; pfam13375 768486005891 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 768486005892 SLBB domain; Region: SLBB; pfam10531 768486005893 Glycine/sarcosine/betaine reductase component B subunits; Region: Gly_reductase; pfam09338 768486005894 potential frameshift: common BLAST hit: gi|260688442|ref|YP_003219576.1| proline reductase 768486005895 Glycine/sarcosine/betaine reductase component B subunits; Region: Gly_reductase; pfam09338 768486005896 proline racemase; Provisional; Region: PRK13969 768486005897 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 768486005898 selenium donor protein; Region: selD; TIGR00476 768486005899 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 768486005900 dimerization interface [polypeptide binding]; other site 768486005901 putative ATP binding site [chemical binding]; other site 768486005902 SirA_like_N, a protein of unknown function with an N-terminal SirA-like domain. The SirA, YedF, YeeD protein family is present in bacteria as well as archaea. SirA (also known as UvrY, and YhhP) belongs to a family of a two-component response...; Region: SirA_like_N; cd03421 768486005903 selenium metabolism protein YedF; Region: selenium_YedF; TIGR03527 768486005904 CPxP motif; other site 768486005905 DsrE/DsrF-like family; Region: DrsE; pfam02635 768486005906 Protein of unknown function (DUF3343); Region: DUF3343; pfam11823 768486005907 Selenocysteine-specific translation elongation factor [Translation, ribosomal structure and biogenesis]; Region: SelB; COG3276 768486005908 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 768486005909 G1 box; other site 768486005910 putative GEF interaction site [polypeptide binding]; other site 768486005911 GTP/Mg2+ binding site [chemical binding]; other site 768486005912 Switch I region; other site 768486005913 G2 box; other site 768486005914 G3 box; other site 768486005915 Switch II region; other site 768486005916 G4 box; other site 768486005917 G5 box; other site 768486005918 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 768486005919 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094 768486005920 Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106 768486005921 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 768486005922 potential frameshift: common BLAST hit: gi|260687733|ref|YP_003218867.1| selenocysteine-specific elongation factor 768486005923 potential frameshift: common BLAST hit: gi|260687733|ref|YP_003218867.1| selenocysteine-specific elongation factor 768486005924 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 768486005925 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 768486005926 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 768486005927 catalytic residue [active] 768486005928 selenocysteine synthase; Provisional; Region: PRK04311 768486005929 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390 768486005930 Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921 768486005931 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 768486005932 catalytic residue [active] 768486005933 seryl-tRNA(sec) selenium transferase; Region: selA; TIGR00474 768486005934 Protein of unknown function (DUF523); Region: DUF523; cl00733 768486005935 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 768486005936 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768486005937 Walker A/P-loop; other site 768486005938 ATP binding site [chemical binding]; other site 768486005939 Q-loop/lid; other site 768486005940 ABC transporter signature motif; other site 768486005941 Walker B; other site 768486005942 D-loop; other site 768486005943 H-loop/switch region; other site 768486005944 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768486005945 dimer interface [polypeptide binding]; other site 768486005946 conserved gate region; other site 768486005947 putative PBP binding loops; other site 768486005948 ABC-ATPase subunit interface; other site 768486005949 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 768486005950 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 768486005951 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 768486005952 Predicted membrane protein [Function unknown]; Region: COG3212 768486005953 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 768486005954 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 768486005955 Dihydroorotate dehydrogenase (DHOD) class 1A FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1A_like; cd04741 768486005956 active site 768486005957 FMN binding site [chemical binding]; other site 768486005958 substrate binding site [chemical binding]; other site 768486005959 catalytic residues [active] 768486005960 homodimer interface [polypeptide binding]; other site 768486005961 amidase; Provisional; Region: PRK06529 768486005962 Amidase; Region: Amidase; cl11426 768486005963 Guanylate kinase; Region: Guanylate_kin; pfam00625 768486005964 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 768486005965 catalytic site [active] 768486005966 G-X2-G-X-G-K; other site 768486005967 potential frameshift: common BLAST hit: gi|389868606|ref|YP_006376029.1| CNT family concentrative nucleoside transporter 768486005968 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 768486005969 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 768486005970 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4868 768486005971 Domain of unknown function (DUF1846); Region: DUF1846; pfam08903 768486005972 phage lysis regulatory protein, LysB family; Region: phage_LysB; TIGR03495 768486005973 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 768486005974 Cation efflux family; Region: Cation_efflux; pfam01545 768486005975 AzlC protein; Region: AzlC; pfam03591 768486005976 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 768486005977 stage V sporulation protein B; Region: spore_V_B; TIGR02900 768486005978 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 768486005979 EDD domain protein, DegV family; Region: DegV; TIGR00762 768486005980 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 768486005981 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 768486005982 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 768486005983 metal ion-dependent adhesion site (MIDAS); other site 768486005984 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 768486005985 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 768486005986 Ca binding site [ion binding]; other site 768486005987 active site 768486005988 catalytic site [active] 768486005989 Protein of unknown function (DUF436); Region: DUF436; pfam04260 768486005990 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; pfam07155 768486005991 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 768486005992 dimer interface [polypeptide binding]; other site 768486005993 substrate binding site [chemical binding]; other site 768486005994 ATP binding site [chemical binding]; other site 768486005995 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 768486005996 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 768486005997 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 768486005998 acyl-activating enzyme (AAE) consensus motif; other site 768486005999 acyl-activating enzyme (AAE) consensus motif; other site 768486006000 AMP binding site [chemical binding]; other site 768486006001 active site 768486006002 CoA binding site [chemical binding]; other site 768486006003 site-specific tyrosine recombinase XerS; Reviewed; Region: xerS; PRK05084 768486006004 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 768486006005 DNA binding site [nucleotide binding] 768486006006 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 768486006007 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 768486006008 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 768486006009 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 768486006010 Walker A/P-loop; other site 768486006011 ATP binding site [chemical binding]; other site 768486006012 Q-loop/lid; other site 768486006013 ABC transporter signature motif; other site 768486006014 Walker B; other site 768486006015 D-loop; other site 768486006016 H-loop/switch region; other site 768486006017 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 768486006018 GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472 768486006019 active site 768486006020 catalytic triad [active] 768486006021 oxyanion hole [active] 768486006022 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 768486006023 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 768486006024 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 768486006025 putative active site [active] 768486006026 putative oxidoreductase; Provisional; Region: PRK10206 768486006027 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 768486006028 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 768486006029 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 768486006030 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 768486006031 tetramer (dimer of dimers) interface [polypeptide binding]; other site 768486006032 NAD binding site [chemical binding]; other site 768486006033 dimer interface [polypeptide binding]; other site 768486006034 substrate binding site [chemical binding]; other site 768486006035 DNA topoisomerase III; Provisional; Region: PRK07726 768486006036 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 768486006037 active site 768486006038 putative interdomain interaction site [polypeptide binding]; other site 768486006039 putative metal-binding site [ion binding]; other site 768486006040 putative nucleotide binding site [chemical binding]; other site 768486006041 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 768486006042 domain I; other site 768486006043 DNA binding groove [nucleotide binding] 768486006044 phosphate binding site [ion binding]; other site 768486006045 domain II; other site 768486006046 domain III; other site 768486006047 nucleotide binding site [chemical binding]; other site 768486006048 catalytic site [active] 768486006049 domain IV; other site 768486006050 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 768486006051 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816 768486006052 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 768486006053 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 768486006054 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 768486006055 shikimate binding site; other site 768486006056 NAD(P) binding site [chemical binding]; other site 768486006057 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 768486006058 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768486006059 Walker A/P-loop; other site 768486006060 ATP binding site [chemical binding]; other site 768486006061 Q-loop/lid; other site 768486006062 ABC transporter signature motif; other site 768486006063 Walker B; other site 768486006064 D-loop; other site 768486006065 H-loop/switch region; other site 768486006066 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 768486006067 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 768486006068 TM-ABC transporter signature motif; other site 768486006069 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 768486006070 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 768486006071 zinc binding site [ion binding]; other site 768486006072 putative ligand binding site [chemical binding]; other site 768486006073 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 768486006074 Domain of unknown function (DUF814); Region: DUF814; pfam05670 768486006075 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 768486006076 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 768486006077 ABC-type metal ion transport system, permease component [Inorganic ion transport and metabolism]; Region: AbcD; COG2011 768486006078 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768486006079 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 768486006080 Walker A/P-loop; other site 768486006081 ATP binding site [chemical binding]; other site 768486006082 Q-loop/lid; other site 768486006083 ABC transporter signature motif; other site 768486006084 Walker B; other site 768486006085 D-loop; other site 768486006086 H-loop/switch region; other site 768486006087 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 768486006088 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768486006089 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768486006090 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 768486006091 dimerization interface [polypeptide binding]; other site 768486006092 potential frameshift: common BLAST hit: gi|29376263|ref|NP_815417.1| carbonic anhydrase 768486006093 HD domain; Region: HD_3; cl17350 768486006094 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 768486006095 active site 768486006096 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 768486006097 active site 768486006098 dimer interface [polypeptide binding]; other site 768486006099 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 768486006100 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 768486006101 heterodimer interface [polypeptide binding]; other site 768486006102 active site 768486006103 FMN binding site [chemical binding]; other site 768486006104 homodimer interface [polypeptide binding]; other site 768486006105 substrate binding site [chemical binding]; other site 768486006106 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 768486006107 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 768486006108 FAD binding pocket [chemical binding]; other site 768486006109 FAD binding motif [chemical binding]; other site 768486006110 phosphate binding motif [ion binding]; other site 768486006111 beta-alpha-beta structure motif; other site 768486006112 NAD binding pocket [chemical binding]; other site 768486006113 Iron coordination center [ion binding]; other site 768486006114 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 768486006115 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 768486006116 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 768486006117 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 768486006118 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 768486006119 ATP-grasp domain; Region: ATP-grasp_4; cl17255 768486006120 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 768486006121 IMP binding site; other site 768486006122 dimer interface [polypeptide binding]; other site 768486006123 interdomain contacts; other site 768486006124 partial ornithine binding site; other site 768486006125 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 768486006126 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 768486006127 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 768486006128 catalytic site [active] 768486006129 subunit interface [polypeptide binding]; other site 768486006130 dihydroorotase; Validated; Region: pyrC; PRK09357 768486006131 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 768486006132 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 768486006133 active site 768486006134 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 768486006135 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 768486006136 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 768486006137 uracil transporter; Provisional; Region: PRK10720 768486006138 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 768486006139 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 768486006140 active site 768486006141 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 768486006142 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 768486006143 RNA binding surface [nucleotide binding]; other site 768486006144 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 768486006145 active site 768486006146 lipoprotein signal peptidase; Provisional; Region: PRK14797 768486006147 lipoprotein signal peptidase; Provisional; Region: PRK14787 768486006148 Predicted transcriptional regulator with C-terminal CBS domains [Transcription]; Region: COG3620 768486006149 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 768486006150 CAAX protease self-immunity; Region: Abi; pfam02517 768486006151 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 768486006152 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 768486006153 Potassium binding sites [ion binding]; other site 768486006154 Cesium cation binding sites [ion binding]; other site 768486006155 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 768486006156 DNA-binding site [nucleotide binding]; DNA binding site 768486006157 RNA-binding motif; other site 768486006158 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 768486006159 RNA/DNA hybrid binding site [nucleotide binding]; other site 768486006160 active site 768486006161 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 768486006162 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 768486006163 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 768486006164 Predicted membrane protein [Function unknown]; Region: COG4684 768486006165 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 768486006166 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 768486006167 motif 1; other site 768486006168 active site 768486006169 motif 2; other site 768486006170 motif 3; other site 768486006171 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 768486006172 DHHA1 domain; Region: DHHA1; pfam02272 768486006173 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 768486006174 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768486006175 Coenzyme A binding pocket [chemical binding]; other site 768486006176 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 768486006177 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 768486006178 ATP binding site [chemical binding]; other site 768486006179 Mg++ binding site [ion binding]; other site 768486006180 motif III; other site 768486006181 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 768486006182 nucleotide binding region [chemical binding]; other site 768486006183 ATP-binding site [chemical binding]; other site 768486006184 potential frameshift: common BLAST hit: gi|389868517|ref|YP_006375940.1| VanZ/RDD domain protein 768486006185 VanZ like family; Region: VanZ; pfam04892 768486006186 RDD family; Region: RDD; pfam06271 768486006187 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 768486006188 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 768486006189 L-threonine dehydrogenase, extended (e) SDRs; Region: TDH_SDR_e; cd05272 768486006190 NAD binding site [chemical binding]; other site 768486006191 homodimer interface [polypeptide binding]; other site 768486006192 active site 768486006193 putative substrate binding site [chemical binding]; other site 768486006194 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 768486006195 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 768486006196 substrate-cofactor binding pocket; other site 768486006197 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768486006198 catalytic residue [active] 768486006199 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 768486006200 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 768486006201 Zn2+ binding site [ion binding]; other site 768486006202 Mg2+ binding site [ion binding]; other site 768486006203 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 768486006204 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 768486006205 active site 768486006206 Zn binding site [ion binding]; other site 768486006207 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 768486006208 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 768486006209 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 768486006210 cell division protein GpsB; Provisional; Region: PRK14127 768486006211 DivIVA domain; Region: DivI1A_domain; TIGR03544 768486006212 hypothetical protein; Provisional; Region: PRK13660 768486006213 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 768486006214 Transglycosylase; Region: Transgly; pfam00912 768486006215 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 768486006216 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 768486006217 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 768486006218 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 768486006219 minor groove reading motif; other site 768486006220 helix-hairpin-helix signature motif; other site 768486006221 substrate binding pocket [chemical binding]; other site 768486006222 active site 768486006223 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 768486006224 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 768486006225 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 768486006226 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 768486006227 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 768486006228 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 768486006229 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 768486006230 metal binding site 2 [ion binding]; metal-binding site 768486006231 putative DNA binding helix; other site 768486006232 metal binding site 1 [ion binding]; metal-binding site 768486006233 dimer interface [polypeptide binding]; other site 768486006234 structural Zn2+ binding site [ion binding]; other site 768486006235 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 768486006236 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 768486006237 dimer interface [polypeptide binding]; other site 768486006238 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768486006239 catalytic residue [active] 768486006240 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 768486006241 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 768486006242 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 768486006243 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 768486006244 TPP-binding site [chemical binding]; other site 768486006245 dimer interface [polypeptide binding]; other site 768486006246 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 768486006247 PYR/PP interface [polypeptide binding]; other site 768486006248 dimer interface [polypeptide binding]; other site 768486006249 TPP binding site [chemical binding]; other site 768486006250 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 768486006251 hypothetical protein; Provisional; Region: PRK02539 768486006252 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 768486006253 putative DNA binding site [nucleotide binding]; other site 768486006254 LexA repressor; Validated; Region: PRK00215 768486006255 putative Zn2+ binding site [ion binding]; other site 768486006256 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 768486006257 Catalytic site [active] 768486006258 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 768486006259 active site 768486006260 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 768486006261 DHH family; Region: DHH; pfam01368 768486006262 DHHA1 domain; Region: DHHA1; pfam02272 768486006263 Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; cl11538 768486006264 Protein of unknown function (DUF1049); Region: DUF1049; cl01539 768486006265 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768486006266 NAD(P) binding site [chemical binding]; other site 768486006267 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 768486006268 active site 768486006269 ribonuclease Z; Region: RNase_Z; TIGR02651 768486006270 GTPase CgtA; Reviewed; Region: obgE; PRK12297 768486006271 GTP1/OBG; Region: GTP1_OBG; pfam01018 768486006272 Obg GTPase; Region: Obg; cd01898 768486006273 G1 box; other site 768486006274 GTP/Mg2+ binding site [chemical binding]; other site 768486006275 Switch I region; other site 768486006276 G2 box; other site 768486006277 G3 box; other site 768486006278 Switch II region; other site 768486006279 G4 box; other site 768486006280 G5 box; other site 768486006281 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 768486006282 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 768486006283 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 768486006284 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 768486006285 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 768486006286 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 768486006287 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 768486006288 Uncharacterized conserved protein [Function unknown]; Region: COG3589 768486006289 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 768486006290 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 768486006291 active site 768486006292 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 768486006293 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK06079 768486006294 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 768486006295 NAD binding site [chemical binding]; other site 768486006296 homotetramer interface [polypeptide binding]; other site 768486006297 homodimer interface [polypeptide binding]; other site 768486006298 substrate binding site [chemical binding]; other site 768486006299 active site 768486006300 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 768486006301 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 768486006302 homodimer interface [polypeptide binding]; other site 768486006303 substrate-cofactor binding pocket; other site 768486006304 catalytic residue [active] 768486006305 potential frameshift: common BLAST hit: gi|389868476|ref|YP_006375899.1| MscS family small conductance mechanosenstive ion channel protein 768486006306 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 768486006307 Mechanosensitive ion channel; Region: MS_channel; pfam00924 768486006308 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 768486006309 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 768486006310 active site 768486006311 metal binding site [ion binding]; metal-binding site 768486006312 homotetramer interface [polypeptide binding]; other site 768486006313 ribonuclease PH; Reviewed; Region: rph; PRK00173 768486006314 Ribonuclease PH; Region: RNase_PH_bact; cd11362 768486006315 hexamer interface [polypeptide binding]; other site 768486006316 active site 768486006317 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 768486006318 active site 768486006319 dimerization interface [polypeptide binding]; other site 768486006320 glutamate racemase; Provisional; Region: PRK00865 768486006321 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 768486006322 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08115 768486006323 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 768486006324 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 768486006325 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 768486006326 active site 768486006327 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 768486006328 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768486006329 dimer interface [polypeptide binding]; other site 768486006330 conserved gate region; other site 768486006331 putative PBP binding loops; other site 768486006332 ABC-ATPase subunit interface; other site 768486006333 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 768486006334 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768486006335 dimer interface [polypeptide binding]; other site 768486006336 conserved gate region; other site 768486006337 putative PBP binding loops; other site 768486006338 ABC-ATPase subunit interface; other site 768486006339 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 768486006340 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 768486006341 substrate binding pocket [chemical binding]; other site 768486006342 membrane-bound complex binding site; other site 768486006343 hinge residues; other site 768486006344 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 768486006345 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 768486006346 Walker A/P-loop; other site 768486006347 ATP binding site [chemical binding]; other site 768486006348 Q-loop/lid; other site 768486006349 ABC transporter signature motif; other site 768486006350 Walker B; other site 768486006351 D-loop; other site 768486006352 H-loop/switch region; other site 768486006353 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 768486006354 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 768486006355 active site 768486006356 HIGH motif; other site 768486006357 dimer interface [polypeptide binding]; other site 768486006358 KMSKS motif; other site 768486006359 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 768486006360 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 768486006361 putative tRNA-binding site [nucleotide binding]; other site 768486006362 B3/4 domain; Region: B3_4; pfam03483 768486006363 tRNA synthetase B5 domain; Region: B5; smart00874 768486006364 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 768486006365 dimer interface [polypeptide binding]; other site 768486006366 motif 1; other site 768486006367 motif 3; other site 768486006368 motif 2; other site 768486006369 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 768486006370 potential frameshift: common BLAST hit: gi|383328358|ref|YP_005354242.1| phenylalanyl-tRNA synthetase subunit alpha 768486006371 phenylalanyl-tRNA synthetase, alpha subunit; Region: pheS; TIGR00468 768486006372 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 768486006373 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 768486006374 dimer interface [polypeptide binding]; other site 768486006375 motif 1; other site 768486006376 active site 768486006377 motif 2; other site 768486006378 motif 3; other site 768486006379 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 768486006380 Predicted transcriptional regulators [Transcription]; Region: COG1733 768486006381 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 768486006382 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 768486006383 Part of AAA domain; Region: AAA_19; pfam13245 768486006384 Family description; Region: UvrD_C_2; pfam13538 768486006385 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 768486006386 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 768486006387 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 768486006388 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768486006389 putative substrate translocation pore; other site 768486006390 POT family; Region: PTR2; cl17359 768486006391 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 768486006392 dimer interface [polypeptide binding]; other site 768486006393 FMN binding site [chemical binding]; other site 768486006394 potential frameshift: common BLAST hit: gi|269202982|ref|YP_003282251.1| fmtC protein 768486006395 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 768486006396 putative active site [active] 768486006397 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 768486006398 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 768486006399 Ligand Binding Site [chemical binding]; other site 768486006400 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 768486006401 Protein of unknown function (DUF1706); Region: DUF1706; cl01748 768486006402 Protein of unknown function (DUF1706); Region: DUF1706; cl01748 768486006403 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768486006404 S-adenosylmethionine binding site [chemical binding]; other site 768486006405 Protein of unknown function (DUF2089); Region: DUF2089; pfam09862 768486006406 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 768486006407 Uncharacterized conserved protein [Function unknown]; Region: COG1284 768486006408 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 768486006409 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 768486006410 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 768486006411 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 768486006412 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 768486006413 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 768486006414 DEAD/DEAH box helicase; Region: DEAD; pfam00270 768486006415 DEAD_2; Region: DEAD_2; pfam06733 768486006416 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 768486006417 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 768486006418 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 768486006419 catalytic core [active] 768486006420 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 768486006421 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 768486006422 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 768486006423 Soluble P-type ATPase [General function prediction only]; Region: COG4087 768486006424 Protein of unknown function (DUF441); Region: DUF441; pfam04284 768486006425 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 768486006426 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 768486006427 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 768486006428 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 768486006429 Competence protein; Region: Competence; pfam03772 768486006430 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 768486006431 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 768486006432 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 768486006433 catalytic motif [active] 768486006434 Zn binding site [ion binding]; other site 768486006435 SLBB domain; Region: SLBB; pfam10531 768486006436 comEA protein; Region: comE; TIGR01259 768486006437 Helix-hairpin-helix motif; Region: HHH; pfam00633 768486006438 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 768486006439 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 768486006440 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 768486006441 protein binding site [polypeptide binding]; other site 768486006442 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 768486006443 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 768486006444 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 768486006445 active site 768486006446 (T/H)XGH motif; other site 768486006447 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 768486006448 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768486006449 S-adenosylmethionine binding site [chemical binding]; other site 768486006450 Uncharacterized protein conserved in bacteria (DUF2129); Region: DUF2129; pfam09902 768486006451 Protein of unknown function (DUF964); Region: DUF964; pfam06133 768486006452 pyruvate carboxylase; Reviewed; Region: PRK12999 768486006453 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 768486006454 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 768486006455 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 768486006456 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 768486006457 active site 768486006458 catalytic residues [active] 768486006459 metal binding site [ion binding]; metal-binding site 768486006460 homodimer binding site [polypeptide binding]; other site 768486006461 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 768486006462 carboxyltransferase (CT) interaction site; other site 768486006463 biotinylation site [posttranslational modification]; other site 768486006464 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 768486006465 Protein of unknown function (DUF1507); Region: DUF1507; cl11487 768486006466 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 768486006467 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 768486006468 ATP binding site [chemical binding]; other site 768486006469 putative Mg++ binding site [ion binding]; other site 768486006470 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 768486006471 nucleotide binding region [chemical binding]; other site 768486006472 ATP-binding site [chemical binding]; other site 768486006473 RQC domain; Region: RQC; pfam09382 768486006474 HRDC domain; Region: HRDC; pfam00570 768486006475 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 768486006476 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 768486006477 G1 box; other site 768486006478 putative GEF interaction site [polypeptide binding]; other site 768486006479 GTP/Mg2+ binding site [chemical binding]; other site 768486006480 Switch I region; other site 768486006481 G2 box; other site 768486006482 G3 box; other site 768486006483 Switch II region; other site 768486006484 G4 box; other site 768486006485 G5 box; other site 768486006486 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 768486006487 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 768486006488 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 768486006489 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 768486006490 active site 768486006491 Uncharacterized protein family (UPF0223); Region: UPF0223; cl11484 768486006492 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 768486006493 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 768486006494 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 768486006495 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 768486006496 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 768486006497 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 768486006498 E3 interaction surface; other site 768486006499 lipoyl attachment site [posttranslational modification]; other site 768486006500 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 768486006501 E3 interaction surface; other site 768486006502 lipoyl attachment site [posttranslational modification]; other site 768486006503 e3 binding domain; Region: E3_binding; pfam02817 768486006504 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 768486006505 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 768486006506 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 768486006507 alpha subunit interface [polypeptide binding]; other site 768486006508 TPP binding site [chemical binding]; other site 768486006509 heterodimer interface [polypeptide binding]; other site 768486006510 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 768486006511 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 768486006512 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 768486006513 tetramer interface [polypeptide binding]; other site 768486006514 TPP-binding site [chemical binding]; other site 768486006515 heterodimer interface [polypeptide binding]; other site 768486006516 phosphorylation loop region [posttranslational modification] 768486006517 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 768486006518 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 768486006519 DNA-binding site [nucleotide binding]; DNA binding site 768486006520 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 768486006521 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768486006522 homodimer interface [polypeptide binding]; other site 768486006523 catalytic residue [active] 768486006524 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 768486006525 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 768486006526 active site 768486006527 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 768486006528 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 768486006529 active site 768486006530 catalytic tetrad [active] 768486006531 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 768486006532 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 768486006533 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 768486006534 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 768486006535 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 768486006536 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 768486006537 dimer interface [polypeptide binding]; other site 768486006538 putative catalytic residues [active] 768486006539 purine monophosphate binding site [chemical binding]; other site 768486006540 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 768486006541 MGS-like domain. This domain composes the whole protein of methylglyoxal synthetase, which catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The family also includes the C-terminal domain in carbamoyl phosphate...; Region: MGS-like; cl00245 768486006542 substrate binding site [chemical binding]; other site 768486006543 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 768486006544 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 768486006545 active site 768486006546 substrate binding site [chemical binding]; other site 768486006547 cosubstrate binding site; other site 768486006548 catalytic site [active] 768486006549 potential frameshift: common BLAST hit: gi|389868394|ref|YP_006375817.1| phosphoribosylformylglycinamidine cyclo-ligase 768486006550 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 768486006551 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 768486006552 dimerization interface [polypeptide binding]; other site 768486006553 putative ATP binding site [chemical binding]; other site 768486006554 Phosphoribosylaminoimidazole (AIR) synthetase [Nucleotide transport and metabolism]; Region: PurM; COG0150 768486006555 amidophosphoribosyltransferase; Provisional; Region: PRK07272 768486006556 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 768486006557 active site 768486006558 tetramer interface [polypeptide binding]; other site 768486006559 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 768486006560 active site 768486006561 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 768486006562 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 768486006563 dimerization interface [polypeptide binding]; other site 768486006564 ATP binding site [chemical binding]; other site 768486006565 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 768486006566 dimerization interface [polypeptide binding]; other site 768486006567 ATP binding site [chemical binding]; other site 768486006568 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 768486006569 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 768486006570 putative active site [active] 768486006571 catalytic triad [active] 768486006572 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700 768486006573 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 768486006574 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 768486006575 ATP binding site [chemical binding]; other site 768486006576 active site 768486006577 substrate binding site [chemical binding]; other site 768486006578 adenylosuccinate lyase; Provisional; Region: PRK07492 768486006579 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 768486006580 tetramer interface [polypeptide binding]; other site 768486006581 active site 768486006582 potential frameshift: common BLAST hit: gi|332686826|ref|YP_004456600.1| phosphoribosylaminoimidazole carboxylase ATPase subunit 768486006583 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 768486006584 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 768486006585 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 768486006586 xanthine permease; Region: pbuX; TIGR03173 768486006587 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 768486006588 active site 768486006589 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 768486006590 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 768486006591 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 768486006592 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 768486006593 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 768486006594 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 768486006595 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 768486006596 Predicted membrane protein [Function unknown]; Region: COG4129 768486006597 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 768486006598 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 768486006599 Predicted membrane protein [Function unknown]; Region: COG4129 768486006600 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 768486006601 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 768486006602 prohibitin homologues; Region: PHB; smart00244 768486006603 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 768486006604 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 768486006605 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 768486006606 motif II; other site 768486006607 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 768486006608 potential frameshift: common BLAST hit: gi|283787031|ref|YP_003366896.1| cation-transporting P-type ATPase 768486006609 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 768486006610 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 768486006611 DNA binding residues [nucleotide binding] 768486006612 dimer interface [polypeptide binding]; other site 768486006613 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 768486006614 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 768486006615 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 768486006616 intersubunit interface [polypeptide binding]; other site 768486006617 active site 768486006618 Zn2+ binding site [ion binding]; other site 768486006619 potential frameshift: common BLAST hit: gi|389868210|ref|YP_006375633.1| hexulose-6-phosphate isomerase 768486006620 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 768486006621 Metal-binding active site; metal-binding site 768486006622 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 768486006623 AP (apurinic/apyrimidinic) site pocket; other site 768486006624 DNA interaction; other site 768486006625 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 768486006626 active site 768486006627 dimer interface [polypeptide binding]; other site 768486006628 magnesium binding site [ion binding]; other site 768486006629 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 768486006630 active site 768486006631 P-loop; other site 768486006632 phosphorylation site [posttranslational modification] 768486006633 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: PRK12997 768486006634 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 768486006635 active site 768486006636 phosphorylation site [posttranslational modification] 768486006637 putative L-ascorbate 6-phosphate lactonase; Provisional; Region: PRK11709 768486006638 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 768486006639 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 768486006640 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 768486006641 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 768486006642 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 768486006643 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 768486006644 active site 768486006645 dimer interface [polypeptide binding]; other site 768486006646 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 768486006647 non-specific DNA binding site [nucleotide binding]; other site 768486006648 salt bridge; other site 768486006649 sequence-specific DNA binding site [nucleotide binding]; other site 768486006650 aminotransferase AlaT; Validated; Region: PRK09265 768486006651 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 768486006652 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768486006653 homodimer interface [polypeptide binding]; other site 768486006654 catalytic residue [active] 768486006655 Domain of unknown function (DUF378); Region: DUF378; pfam04070 768486006656 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 768486006657 Plasmid recombination enzyme; Region: Mob_Pre; pfam01076 768486006658 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 768486006659 M protein trans-acting positive regulator (MGA) HTH domain; Region: HTH_Mga; pfam08280 768486006660 Mga helix-turn-helix domain; Region: Mga; pfam05043 768486006661 Mga helix-turn-helix domain; Region: Mga; pfam05043 768486006662 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 768486006663 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 768486006664 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 768486006665 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 768486006666 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 768486006667 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768486006668 Walker A/P-loop; other site 768486006669 ATP binding site [chemical binding]; other site 768486006670 Q-loop/lid; other site 768486006671 ABC transporter signature motif; other site 768486006672 Walker B; other site 768486006673 D-loop; other site 768486006674 H-loop/switch region; other site 768486006675 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768486006676 dimer interface [polypeptide binding]; other site 768486006677 conserved gate region; other site 768486006678 ABC-ATPase subunit interface; other site 768486006679 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 768486006680 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 768486006681 Uncharacterized conserved protein [Function unknown]; Region: COG1284 768486006682 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 768486006683 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 768486006684 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 768486006685 putative NAD(P) binding site [chemical binding]; other site 768486006686 dimer interface [polypeptide binding]; other site 768486006687 Transcriptional regulators [Transcription]; Region: PurR; COG1609 768486006688 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 768486006689 DNA binding site [nucleotide binding] 768486006690 domain linker motif; other site 768486006691 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 768486006692 ligand binding site [chemical binding]; other site 768486006693 dimerization interface [polypeptide binding]; other site 768486006694 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 768486006695 Domain of unknown function (DUF1803); Region: DUF1803; pfam08820 768486006696 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 768486006697 DHH family; Region: DHH; pfam01368 768486006698 DHHA2 domain; Region: DHHA2; pfam02833 768486006699 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 768486006700 beta-galactosidase; Region: BGL; TIGR03356 768486006701 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 768486006702 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 768486006703 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 768486006704 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 768486006705 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768486006706 dimer interface [polypeptide binding]; other site 768486006707 conserved gate region; other site 768486006708 putative PBP binding loops; other site 768486006709 ABC-ATPase subunit interface; other site 768486006710 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 768486006711 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768486006712 dimer interface [polypeptide binding]; other site 768486006713 conserved gate region; other site 768486006714 ABC-ATPase subunit interface; other site 768486006715 Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119 768486006716 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 768486006717 Protein of unknown function, DUF624; Region: DUF624; cl02369 768486006718 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 768486006719 Glycosyl hydrolase family 20 (GH20) catalytic domain of N-acetyl-beta-D-glucosaminidase (GcnA, also known as BhsA) and related proteins. GcnA is an exoglucosidase which cleaves N-acetyl-beta-D-galactosamine (NAG) and N-acetyl-beta-D-galactosamine...; Region: GH20_GcnA-like; cd06565 768486006720 putative active site [active] 768486006721 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 768486006722 Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119 768486006723 potential frameshift: common BLAST hit: gi|251795515|ref|YP_003010246.1| AraC family transcriptional regulator 768486006724 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 768486006725 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 768486006726 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 768486006727 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 768486006728 FeS/SAM binding site; other site 768486006729 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 768486006730 Pyruvate formate lyase 1; Region: PFL1; cd01678 768486006731 coenzyme A binding site [chemical binding]; other site 768486006732 active site 768486006733 catalytic residues [active] 768486006734 glycine loop; other site 768486006735 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 768486006736 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 768486006737 CAP-like domain; other site 768486006738 active site 768486006739 primary dimer interface [polypeptide binding]; other site 768486006740 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 768486006741 potential frameshift: common BLAST hit: gi|29376174|ref|NP_815328.1| DNA topoisomerase IV subunit B 768486006742 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 768486006743 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 768486006744 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 768486006745 active site 768486006746 catalytic residues [active] 768486006747 transcriptional repressor CodY; Validated; Region: PRK04158 768486006748 CodY GAF-like domain; Region: CodY; pfam06018 768486006749 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 768486006750 putative DNA binding site [nucleotide binding]; other site 768486006751 putative Zn2+ binding site [ion binding]; other site 768486006752 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 768486006753 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 768486006754 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768486006755 Walker A motif; other site 768486006756 ATP binding site [chemical binding]; other site 768486006757 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 768486006758 Walker B motif; other site 768486006759 arginine finger; other site 768486006760 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 768486006761 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 768486006762 active site 768486006763 HslU subunit interaction site [polypeptide binding]; other site 768486006764 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 768486006765 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 768486006766 active site 768486006767 Int/Topo IB signature motif; other site 768486006768 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 768486006769 Glucose inhibited division protein A; Region: GIDA; pfam01134 768486006770 DNA topoisomerase I; Validated; Region: PRK05582 768486006771 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 768486006772 active site 768486006773 interdomain interaction site; other site 768486006774 putative metal-binding site [ion binding]; other site 768486006775 nucleotide binding site [chemical binding]; other site 768486006776 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 768486006777 domain I; other site 768486006778 DNA binding groove [nucleotide binding] 768486006779 phosphate binding site [ion binding]; other site 768486006780 domain II; other site 768486006781 domain III; other site 768486006782 nucleotide binding site [chemical binding]; other site 768486006783 catalytic site [active] 768486006784 domain IV; other site 768486006785 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 768486006786 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 768486006787 DNA protecting protein DprA; Region: dprA; TIGR00732 768486006788 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 768486006789 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 768486006790 RNA/DNA hybrid binding site [nucleotide binding]; other site 768486006791 active site 768486006792 ribosome biogenesis GTP-binding protein YlqF; Region: GTPase_YlqF; TIGR03596 768486006793 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 768486006794 GTP/Mg2+ binding site [chemical binding]; other site 768486006795 G4 box; other site 768486006796 G5 box; other site 768486006797 G1 box; other site 768486006798 Switch I region; other site 768486006799 G2 box; other site 768486006800 G3 box; other site 768486006801 Switch II region; other site 768486006802 LytTr DNA-binding domain; Region: LytTR; pfam04397 768486006803 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 768486006804 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 768486006805 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 768486006806 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 768486006807 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 768486006808 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 768486006809 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462 768486006810 Catalytic site [active] 768486006811 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 768486006812 hypothetical protein; Provisional; Region: PRK13672 768486006813 methionine sulfoxide reductase A; Provisional; Region: PRK14054 768486006814 Uncharacterized protein conserved in bacteria (DUF2140); Region: DUF2140; pfam09911 768486006815 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 768486006816 active site 768486006817 catalytic triad [active] 768486006818 oxyanion hole [active] 768486006819 EDD domain protein, DegV family; Region: DegV; TIGR00762 768486006820 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 768486006821 thymidylate synthase; Region: thym_sym; TIGR03284 768486006822 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 768486006823 dimerization interface [polypeptide binding]; other site 768486006824 active site 768486006825 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 768486006826 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 768486006827 folate binding site [chemical binding]; other site 768486006828 NADP+ binding site [chemical binding]; other site 768486006829 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 768486006830 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768486006831 Walker A/P-loop; other site 768486006832 ATP binding site [chemical binding]; other site 768486006833 Q-loop/lid; other site 768486006834 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 768486006835 ABC transporter signature motif; other site 768486006836 Walker B; other site 768486006837 D-loop; other site 768486006838 ABC transporter; Region: ABC_tran_2; pfam12848 768486006839 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 768486006840 Putative cyclase; Region: Cyclase; pfam04199 768486006841 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 768486006842 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 768486006843 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 768486006844 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 768486006845 ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell; Region: ADP_ribosyl; cl00283 768486006846 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 768486006847 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 768486006848 active site 768486006849 NTP binding site [chemical binding]; other site 768486006850 metal binding triad [ion binding]; metal-binding site 768486006851 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 768486006852 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 768486006853 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531 768486006854 homodimer interface [polypeptide binding]; other site 768486006855 metal binding site [ion binding]; metal-binding site 768486006856 Uncharacterized conserved protein [Function unknown]; Region: COG1284 768486006857 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 768486006858 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 768486006859 UPF0302 domain; Region: UPF0302; pfam08864 768486006860 IDEAL domain; Region: IDEAL; pfam08858 768486006861 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 768486006862 TPR motif; other site 768486006863 binding surface 768486006864 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 768486006865 binding surface 768486006866 TPR motif; other site 768486006867 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 768486006868 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 768486006869 IHF dimer interface [polypeptide binding]; other site 768486006870 IHF - DNA interface [nucleotide binding]; other site 768486006871 GTP-binding protein Der; Reviewed; Region: PRK00093 768486006872 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 768486006873 G1 box; other site 768486006874 GTP/Mg2+ binding site [chemical binding]; other site 768486006875 Switch I region; other site 768486006876 G2 box; other site 768486006877 Switch II region; other site 768486006878 G3 box; other site 768486006879 G4 box; other site 768486006880 G5 box; other site 768486006881 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 768486006882 G1 box; other site 768486006883 GTP/Mg2+ binding site [chemical binding]; other site 768486006884 Switch I region; other site 768486006885 G2 box; other site 768486006886 G3 box; other site 768486006887 Switch II region; other site 768486006888 G4 box; other site 768486006889 G5 box; other site 768486006890 Transcriptional regulators [Transcription]; Region: PurR; COG1609 768486006891 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 768486006892 DNA binding site [nucleotide binding] 768486006893 domain linker motif; other site 768486006894 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 768486006895 dimerization interface [polypeptide binding]; other site 768486006896 ligand binding site [chemical binding]; other site 768486006897 sodium binding site [ion binding]; other site 768486006898 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 768486006899 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 768486006900 substrate binding [chemical binding]; other site 768486006901 active site 768486006902 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 768486006903 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 768486006904 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 768486006905 active site turn [active] 768486006906 phosphorylation site [posttranslational modification] 768486006907 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 768486006908 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 768486006909 HPr interaction site; other site 768486006910 glycerol kinase (GK) interaction site [polypeptide binding]; other site 768486006911 active site 768486006912 phosphorylation site [posttranslational modification] 768486006913 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 768486006914 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 768486006915 nucleotide binding site [chemical binding]; other site 768486006916 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 768486006917 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 768486006918 RNA binding site [nucleotide binding]; other site 768486006919 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 768486006920 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 768486006921 RNA binding site [nucleotide binding]; other site 768486006922 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 768486006923 RNA binding site [nucleotide binding]; other site 768486006924 cytidylate kinase; Provisional; Region: cmk; PRK00023 768486006925 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 768486006926 CMP-binding site; other site 768486006927 The sites determining sugar specificity; other site 768486006928 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 768486006929 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 768486006930 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 768486006931 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 768486006932 ATP binding site [chemical binding]; other site 768486006933 putative Mg++ binding site [ion binding]; other site 768486006934 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 768486006935 nucleotide binding region [chemical binding]; other site 768486006936 ATP-binding site [chemical binding]; other site 768486006937 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 768486006938 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 768486006939 4Fe-4S single cluster domain; Region: Fer4_13; pfam13370 768486006940 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 768486006941 hypothetical protein; Provisional; Region: PRK07205 768486006942 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 768486006943 active site 768486006944 metal binding site [ion binding]; metal-binding site 768486006945 Predicted membrane protein [Function unknown]; Region: COG1288 768486006946 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 768486006947 Predicted membrane protein [Function unknown]; Region: COG3601 768486006948 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 768486006949 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 768486006950 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 768486006951 RNA binding surface [nucleotide binding]; other site 768486006952 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 768486006953 active site 768486006954 Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612 768486006955 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 768486006956 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 768486006957 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 768486006958 active site 768486006959 Int/Topo IB signature motif; other site 768486006960 ferric uptake regulator; Provisional; Region: fur; PRK09462 768486006961 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 768486006962 metal binding site 2 [ion binding]; metal-binding site 768486006963 putative DNA binding helix; other site 768486006964 metal binding site 1 [ion binding]; metal-binding site 768486006965 dimer interface [polypeptide binding]; other site 768486006966 structural Zn2+ binding site [ion binding]; other site 768486006967 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 768486006968 S1 domain; Region: S1_2; pfam13509 768486006969 TFIIB zinc-binding; Region: TF_Zn_Ribbon; pfam08271 768486006970 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 768486006971 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 768486006972 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 768486006973 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 768486006974 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 768486006975 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 768486006976 DNA binding residues [nucleotide binding] 768486006977 DNA primase; Validated; Region: dnaG; PRK05667 768486006978 CHC2 zinc finger; Region: zf-CHC2; pfam01807 768486006979 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 768486006980 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 768486006981 active site 768486006982 metal binding site [ion binding]; metal-binding site 768486006983 interdomain interaction site; other site 768486006984 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 768486006985 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 768486006986 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 768486006987 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 768486006988 motif II; other site 768486006989 Domain of unknown function (DUF368); Region: DUF368; cl00893 768486006990 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 768486006991 N-acetyl-D-glucosamine binding site [chemical binding]; other site 768486006992 catalytic residue [active] 768486006993 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 768486006994 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 768486006995 Serine hydrolase (FSH1); Region: FSH1; pfam03959 768486006996 Predicted integral membrane protein [Function unknown]; Region: COG0392 768486006997 Uncharacterized conserved protein [Function unknown]; Region: COG2898 768486006998 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 768486006999 elongation factor Tu; Reviewed; Region: PRK00049 768486007000 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 768486007001 G1 box; other site 768486007002 GEF interaction site [polypeptide binding]; other site 768486007003 GTP/Mg2+ binding site [chemical binding]; other site 768486007004 Switch I region; other site 768486007005 G2 box; other site 768486007006 G3 box; other site 768486007007 Switch II region; other site 768486007008 G4 box; other site 768486007009 G5 box; other site 768486007010 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 768486007011 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 768486007012 Antibiotic Binding Site [chemical binding]; other site 768486007013 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 768486007014 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768486007015 Coenzyme A binding pocket [chemical binding]; other site 768486007016 GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718 768486007017 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_3; cd07241 768486007018 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 768486007019 putative metal binding site [ion binding]; other site 768486007020 37-kD nucleoid-associated bacterial protein; Region: NA37; cl15473 768486007021 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 768486007022 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 768486007023 active site 768486007024 catalytic tetrad [active] 768486007025 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 768486007026 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 768486007027 active site 768486007028 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 768486007029 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 768486007030 homodimer interface [polypeptide binding]; other site 768486007031 catalytic residues [active] 768486007032 NAD binding site [chemical binding]; other site 768486007033 substrate binding pocket [chemical binding]; other site 768486007034 flexible flap; other site 768486007035 putative acyltransferase; Provisional; Region: PRK05790 768486007036 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 768486007037 dimer interface [polypeptide binding]; other site 768486007038 active site 768486007039 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 768486007040 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835 768486007041 dimer interface [polypeptide binding]; other site 768486007042 active site 768486007043 Viral enhancin protein; Region: Enhancin; pfam03272 768486007044 Peptidase M60-like family; Region: M60-like; pfam13402 768486007045 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768486007046 S-adenosylmethionine binding site [chemical binding]; other site 768486007047 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 768486007048 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 768486007049 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 768486007050 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 768486007051 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 768486007052 motif II; other site 768486007053 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 768486007054 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 768486007055 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 768486007056 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 768486007057 putative active site [active] 768486007058 catalytic site [active] 768486007059 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 768486007060 putative active site [active] 768486007061 catalytic site [active] 768486007062 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 768486007063 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 768486007064 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 768486007065 WxL domain surface cell wall-binding; Region: WxL; pfam13731 768486007066 WxL domain surface cell wall-binding; Region: WxL; pfam13731 768486007067 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 768486007068 Class I aldolases; Region: Aldolase_Class_I; cl17187 768486007069 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 768486007070 active site 768486007071 phosphorylation site [posttranslational modification] 768486007072 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 768486007073 active site 768486007074 P-loop; other site 768486007075 phosphorylation site [posttranslational modification] 768486007076 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 768486007077 potential frameshift: common BLAST hit: gi|29375290|ref|NP_814443.1| 1-phosphofructokinase 768486007078 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 768486007079 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 768486007080 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 768486007081 putative active site [active] 768486007082 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 768486007083 dimer interface [polypeptide binding]; other site 768486007084 substrate binding site [chemical binding]; other site 768486007085 ATP binding site [chemical binding]; other site 768486007086 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 768486007087 Ligand Binding Site [chemical binding]; other site 768486007088 potential frameshift: common BLAST hit: gi|317131824|ref|YP_004091138.1| 6-phospho-beta-glucosidase 768486007089 potential frameshift: common BLAST hit: gi|383328570|ref|YP_005354454.1| PTS system lactose/cellobiose-specific transporter subunit IIC 768486007090 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 768486007091 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 768486007092 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 768486007093 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 768486007094 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 768486007095 DNA-binding site [nucleotide binding]; DNA binding site 768486007096 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 768486007097 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 768486007098 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 768486007099 Zn binding site [ion binding]; other site 768486007100 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 768486007101 Zn binding site [ion binding]; other site 768486007102 Predicted esterase [General function prediction only]; Region: COG0400 768486007103 WxL domain surface cell wall-binding; Region: WxL; pfam13731 768486007104 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 768486007105 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 768486007106 PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; pfam03829 768486007107 Predicted homoserine dehydrogenase [Amino acid transport and metabolism]; Region: COG4091 768486007108 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 768486007109 SAF domain of putative dehydrogenases or oxidoreductases; Region: SAF_DH_OX_like; cd11616 768486007110 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_10; cd12171 768486007111 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 768486007112 putative ligand binding site [chemical binding]; other site 768486007113 putative NAD binding site [chemical binding]; other site 768486007114 catalytic site [active] 768486007115 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 768486007116 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 768486007117 NAD(P) binding site [chemical binding]; other site 768486007118 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 768486007119 Phosphotransferase system sorbitol-specific component IIBC [Carbohydrate transport and metabolism]; Region: SrlE; COG3732 768486007120 Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663 768486007121 PTS system enzyme II sorbitol-specific factor; Region: EII-GUT; cl01515 768486007122 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 768486007123 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 768486007124 DNA binding residues [nucleotide binding] 768486007125 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 768486007126 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 768486007127 dimer interface [polypeptide binding]; other site 768486007128 substrate binding site [chemical binding]; other site 768486007129 ATP binding site [chemical binding]; other site 768486007130 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 768486007131 substrate binding site [chemical binding]; other site 768486007132 multimerization interface [polypeptide binding]; other site 768486007133 ATP binding site [chemical binding]; other site 768486007134 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 768486007135 thiamine phosphate binding site [chemical binding]; other site 768486007136 active site 768486007137 pyrophosphate binding site [ion binding]; other site 768486007138 Putative transcription activator [Transcription]; Region: TenA; COG0819 768486007139 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 768486007140 Zn2+ binding site [ion binding]; other site 768486007141 Mg2+ binding site [ion binding]; other site 768486007142 potential protein location (hypothetical protein EHR_13975 [Enterococcus hirae ATCC 9790]) that overlaps RNA (tRNA-H) 768486007143 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 768486007144 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 768486007145 dimerization interface [polypeptide binding]; other site 768486007146 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768486007147 dimer interface [polypeptide binding]; other site 768486007148 phosphorylation site [posttranslational modification] 768486007149 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768486007150 ATP binding site [chemical binding]; other site 768486007151 Mg2+ binding site [ion binding]; other site 768486007152 G-X-G motif; other site 768486007153 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 768486007154 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768486007155 active site 768486007156 phosphorylation site [posttranslational modification] 768486007157 intermolecular recognition site; other site 768486007158 dimerization interface [polypeptide binding]; other site 768486007159 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 768486007160 DNA binding site [nucleotide binding] 768486007161 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 768486007162 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 768486007163 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 768486007164 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 768486007165 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 768486007166 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768486007167 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768486007168 The substrate binding domain of LysR-type transcriptional regulator MleR which required for malolactic fermentation, contains type 2 periplasmic binidning fold; Region: PBP2_MleR; cd08437 768486007169 putative dimerization interface [polypeptide binding]; other site 768486007170 pyruvate kinase; Provisional; Region: PRK06354 768486007171 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 768486007172 active site 768486007173 domain interfaces; other site 768486007174 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 768486007175 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 768486007176 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 768486007177 active site 768486007178 ADP/pyrophosphate binding site [chemical binding]; other site 768486007179 dimerization interface [polypeptide binding]; other site 768486007180 allosteric effector site; other site 768486007181 fructose-1,6-bisphosphate binding site; other site 768486007182 potential frameshift: common BLAST hit: gi|29375623|ref|NP_814777.1| DNA polymerase III, alpha subunit 768486007183 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 768486007184 drug efflux system protein MdtG; Provisional; Region: PRK09874 768486007185 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768486007186 putative substrate translocation pore; other site 768486007187 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768486007188 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 768486007189 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 768486007190 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 768486007191 active site 768486007192 motif I; other site 768486007193 motif II; other site 768486007194 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 768486007195 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 768486007196 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 768486007197 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 768486007198 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 768486007199 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 768486007200 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 768486007201 putative active site [active] 768486007202 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 768486007203 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 768486007204 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 768486007205 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 768486007206 active site 768486007207 dimer interface [polypeptide binding]; other site 768486007208 motif 1; other site 768486007209 motif 2; other site 768486007210 motif 3; other site 768486007211 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 768486007212 anticodon binding site; other site 768486007213 4-oxalocrotonate tautomerase; Provisional; Region: PRK02220 768486007214 active site 1 [active] 768486007215 dimer interface [polypeptide binding]; other site 768486007216 hexamer interface [polypeptide binding]; other site 768486007217 active site 2 [active] 768486007218 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 768486007219 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 768486007220 Soluble P-type ATPase [General function prediction only]; Region: COG4087 768486007221 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 768486007222 Part of AAA domain; Region: AAA_19; pfam13245 768486007223 Family description; Region: UvrD_C_2; pfam13538 768486007224 hypothetical protein; Provisional; Region: PRK12378 768486007225 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673 768486007226 hypothetical protein; Provisional; Region: PRK13670 768486007227 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768486007228 S-adenosylmethionine binding site [chemical binding]; other site 768486007229 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 768486007230 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 768486007231 Zn2+ binding site [ion binding]; other site 768486007232 Mg2+ binding site [ion binding]; other site 768486007233 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 768486007234 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 768486007235 active site 768486007236 (T/H)XGH motif; other site 768486007237 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 768486007238 GTPase YqeH; Provisional; Region: PRK13796 768486007239 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 768486007240 GTP/Mg2+ binding site [chemical binding]; other site 768486007241 G4 box; other site 768486007242 G5 box; other site 768486007243 G1 box; other site 768486007244 Switch I region; other site 768486007245 G2 box; other site 768486007246 G3 box; other site 768486007247 Switch II region; other site 768486007248 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 768486007249 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 768486007250 active site 768486007251 motif I; other site 768486007252 motif II; other site 768486007253 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 768486007254 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 768486007255 Walker A/P-loop; other site 768486007256 ATP binding site [chemical binding]; other site 768486007257 Q-loop/lid; other site 768486007258 ABC transporter signature motif; other site 768486007259 Walker B; other site 768486007260 D-loop; other site 768486007261 H-loop/switch region; other site 768486007262 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 768486007263 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768486007264 dimer interface [polypeptide binding]; other site 768486007265 conserved gate region; other site 768486007266 putative PBP binding loops; other site 768486007267 ABC-ATPase subunit interface; other site 768486007268 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 768486007269 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 768486007270 substrate binding pocket [chemical binding]; other site 768486007271 membrane-bound complex binding site; other site 768486007272 hinge residues; other site 768486007273 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 768486007274 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 768486007275 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 768486007276 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 768486007277 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 768486007278 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 768486007279 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 768486007280 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 768486007281 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 768486007282 potential frameshift: common BLAST hit: gi|29377343|ref|NP_816497.1| acetyl-CoA carboxylase biotin carboxylase subunit 768486007283 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 768486007284 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 768486007285 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 768486007286 carboxyltransferase (CT) interaction site; other site 768486007287 biotinylation site [posttranslational modification]; other site 768486007288 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 768486007289 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 768486007290 dimer interface [polypeptide binding]; other site 768486007291 active site 768486007292 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 768486007293 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 768486007294 NAD(P) binding site [chemical binding]; other site 768486007295 homotetramer interface [polypeptide binding]; other site 768486007296 homodimer interface [polypeptide binding]; other site 768486007297 active site 768486007298 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 768486007299 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 768486007300 acyl carrier protein; Provisional; Region: acpP; PRK00982 768486007301 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 768486007302 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 768486007303 dimer interface [polypeptide binding]; other site 768486007304 active site 768486007305 CoA binding pocket [chemical binding]; other site 768486007306 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 768486007307 MarR family; Region: MarR_2; pfam12802 768486007308 Nuclease subunit of the excinuclease complex [DNA replication, recombination, and repair]; Region: UvrC; COG0322 768486007309 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 768486007310 GIY-YIG motif/motif A; other site 768486007311 active site 768486007312 catalytic site [active] 768486007313 putative DNA binding site [nucleotide binding]; other site 768486007314 metal binding site [ion binding]; metal-binding site 768486007315 Protein of unknown function (DUF1797); Region: DUF1797; pfam08796 768486007316 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 768486007317 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 768486007318 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 768486007319 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 768486007320 putative ADP-binding pocket [chemical binding]; other site 768486007321 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 768486007322 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 768486007323 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 768486007324 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 768486007325 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 768486007326 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 768486007327 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 768486007328 dimerization domain swap beta strand [polypeptide binding]; other site 768486007329 regulatory protein interface [polypeptide binding]; other site 768486007330 active site 768486007331 regulatory phosphorylation site [posttranslational modification]; other site 768486007332 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768486007333 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 768486007334 Walker A motif; other site 768486007335 ATP binding site [chemical binding]; other site 768486007336 Walker B motif; other site 768486007337 arginine finger; other site 768486007338 UvrB/uvrC motif; Region: UVR; pfam02151 768486007339 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768486007340 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 768486007341 Walker A motif; other site 768486007342 ATP binding site [chemical binding]; other site 768486007343 Walker B motif; other site 768486007344 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 768486007345 Domain of unknown function (DUF1827); Region: DUF1827; pfam08860 768486007346 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 768486007347 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 768486007348 active site 768486007349 homodimer interface [polypeptide binding]; other site 768486007350 potential frameshift: common BLAST hit: gi|29375298|ref|NP_814452.1| peptide chain release factor 3 768486007351 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 768486007352 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 768486007353 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 768486007354 Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues; Region: GAG_Lyase; cd01083 768486007355 substrate binding site [chemical binding]; other site 768486007356 catalytic residues [active] 768486007357 CAMP factor (Cfa); Region: CAMP_factor; pfam07373 768486007358 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 768486007359 Domain of unknown function DUF21; Region: DUF21; pfam01595 768486007360 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 768486007361 Transporter associated domain; Region: CorC_HlyC; pfam03471 768486007362 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 768486007363 Domain of unknown function DUF20; Region: UPF0118; pfam01594 768486007364 Autoinducer synthetase; Region: Autoind_synth; cl17404 768486007365 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 768486007366 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768486007367 Coenzyme A binding pocket [chemical binding]; other site 768486007368 hypothetical protein; Provisional; Region: PRK13662 768486007369 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 768486007370 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 768486007371 minor groove reading motif; other site 768486007372 helix-hairpin-helix signature motif; other site 768486007373 substrate binding pocket [chemical binding]; other site 768486007374 active site 768486007375 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 768486007376 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 768486007377 DNA binding and oxoG recognition site [nucleotide binding] 768486007378 RecX family; Region: RecX; cl00936 768486007379 TRAM domain; Region: TRAM; pfam01938 768486007380 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 768486007381 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768486007382 S-adenosylmethionine binding site [chemical binding]; other site 768486007383 Uncharacterized protein/domain associated with GTPases [Function unknown]; Region: COG3597 768486007384 Chitin binding domain; Region: Chitin_bind_3; pfam03067 768486007385 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 768486007386 active site 768486007387 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 768486007388 Interdomain contacts; other site 768486007389 Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979 768486007390 Cytokine receptor motif; other site 768486007391 chitin-binding domain of Chi A1-like proteins; Region: ChiA1_BD; cd12214 768486007392 TspO/MBR family; Region: TspO_MBR; pfam03073 768486007393 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 768486007394 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 768486007395 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245