-- dump date 20140619_075223 -- class Genbank::misc_feature -- table misc_feature_note -- id note 665029000001 Initiator Replication protein; Region: Rep_3; pfam01051 665029000002 global DNA-binding transcriptional dual regulator H-NS; Provisional; Region: PRK10947 665029000003 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 665029000004 Omptin family; Region: Omptin; cl01886 665029000005 Transcriptional regulator [Transcription]; Region: LysR; COG0583 665029000006 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 665029000007 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 665029000008 putative dimerization interface [polypeptide binding]; other site 665029000009 putative succinate semialdehyde dehydrogenase; Provisional; Region: PRK13968 665029000010 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 665029000011 NAD(P) binding site [chemical binding]; other site 665029000012 catalytic residues [active] 665029000013 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 665029000014 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 665029000015 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 665029000016 dimer interface [polypeptide binding]; other site 665029000017 putative CheW interface [polypeptide binding]; other site 665029000018 Uncharacterized conserved protein (DUF2132); Region: DUF2132; pfam09905 665029000019 HipA N-terminal domain; Region: Couple_hipA; pfam13657 665029000020 HipA-like N-terminal domain; Region: HipA_N; pfam07805 665029000021 HipA-like C-terminal domain; Region: HipA_C; pfam07804 665029000022 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 665029000023 thiazole biosynthesis adenylyltransferase ThiF, E. coli subfamily; Region: adenyl_thiF; TIGR02356 665029000024 ATP binding site [chemical binding]; other site 665029000025 substrate interface [chemical binding]; other site 665029000026 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 665029000027 active site residue [active] 665029000028 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 665029000029 ThiS interaction site; other site 665029000030 putative active site [active] 665029000031 tetramer interface [polypeptide binding]; other site 665029000032 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 665029000033 thiS-thiF/thiG interaction site; other site 665029000034 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 665029000035 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 665029000036 PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872 665029000037 putative active site [active] 665029000038 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 665029000039 ParG; Region: ParG; pfam09274 665029000040 ParA-like protein; Provisional; Region: PHA02518 665029000041 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 665029000042 P-loop; other site 665029000043 Magnesium ion binding site [ion binding]; other site 665029000044 multiple promoter invertase; Provisional; Region: mpi; PRK13413 665029000045 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 665029000046 catalytic residues [active] 665029000047 catalytic nucleophile [active] 665029000048 Presynaptic Site I dimer interface [polypeptide binding]; other site 665029000049 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 665029000050 Synaptic Flat tetramer interface [polypeptide binding]; other site 665029000051 Synaptic Site I dimer interface [polypeptide binding]; other site 665029000052 DNA binding site [nucleotide binding] 665029000053 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 665029000054 DNA-binding interface [nucleotide binding]; DNA binding site 665029000055 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 665029000056 S-adenosylmethionine binding site [chemical binding]; other site 665029000057 choline transport protein BetT; Provisional; Region: PRK09928 665029000058 hypothetical protein; Provisional; Region: PRK09956 665029000059 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 665029000060 methionine sulfoxide reductase A; Provisional; Region: PRK14054 665029000061 FMN-binding protein MioC; Provisional; Region: PRK09004 665029000062 DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179 665029000063 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 665029000064 putative DNA binding site [nucleotide binding]; other site 665029000065 putative Zn2+ binding site [ion binding]; other site 665029000066 AsnC family; Region: AsnC_trans_reg; pfam01037 665029000067 5-histidylcysteine sulfoxide synthase; Region: ovoA_Nterm; TIGR04344 665029000068 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 665029000069 Methyltransferase domain; Region: Methyltransf_23; pfam13489 665029000070 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 665029000071 S-adenosylmethionine binding site [chemical binding]; other site 665029000072 hypothetical protein; Provisional; Region: yieM; PRK10997 665029000073 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 665029000074 metal ion-dependent adhesion site (MIDAS); other site 665029000075 regulatory ATPase RavA; Provisional; Region: PRK13531 665029000076 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 665029000077 Walker A motif; other site 665029000078 ATP binding site [chemical binding]; other site 665029000079 Walker B motif; other site 665029000080 arginine finger; other site 665029000081 Protein of unknown function (DUF3763); Region: DUF3763; pfam12592 665029000082 potassium transport protein Kup; Provisional; Region: trkD; PRK10745 665029000083 potassium uptake protein; Region: kup; TIGR00794 665029000084 Periplasmic protein with OB-fold [Function unknown]; Region: COG3111 665029000085 Transcriptional regulator [Transcription]; Region: LysR; COG0583 665029000086 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 665029000087 The C-terminal substrate binding domain of LysR-type transcrptional regulator BudR, which is responsible for activation of the expression of the butanediol operon genes; contains the type 2 periplasmic binding fold; Region: PBP2_BudR; cd08451 665029000088 putative dimerization interface [polypeptide binding]; other site 665029000089 putative substrate binding pocket [chemical binding]; other site 665029000090 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306 665029000091 acetolactate synthase; Reviewed; Region: PRK08617 665029000092 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 665029000093 PYR/PP interface [polypeptide binding]; other site 665029000094 dimer interface [polypeptide binding]; other site 665029000095 TPP binding site [chemical binding]; other site 665029000096 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 665029000097 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 665029000098 TPP-binding site [chemical binding]; other site 665029000099 D-ribose pyranase; Provisional; Region: PRK11797 665029000100 D-ribose transporter ATP binding protein; Provisional; Region: PRK10762 665029000101 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 665029000102 Walker A/P-loop; other site 665029000103 ATP binding site [chemical binding]; other site 665029000104 Q-loop/lid; other site 665029000105 ABC transporter signature motif; other site 665029000106 Walker B; other site 665029000107 D-loop; other site 665029000108 H-loop/switch region; other site 665029000109 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 665029000110 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 665029000111 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 665029000112 TM-ABC transporter signature motif; other site 665029000113 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 665029000114 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 665029000115 ligand binding site [chemical binding]; other site 665029000116 dimerization interface [polypeptide binding]; other site 665029000117 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 665029000118 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 665029000119 substrate binding site [chemical binding]; other site 665029000120 dimer interface [polypeptide binding]; other site 665029000121 ATP binding site [chemical binding]; other site 665029000122 transcriptional repressor RbsR; Provisional; Region: PRK10423 665029000123 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 665029000124 DNA binding site [nucleotide binding] 665029000125 domain linker motif; other site 665029000126 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 665029000127 dimerization interface [polypeptide binding]; other site 665029000128 ligand binding site [chemical binding]; other site 665029000129 putative transporter; Provisional; Region: PRK10504 665029000130 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 665029000131 putative substrate translocation pore; other site 665029000132 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 665029000133 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 665029000134 GTP binding site; other site 665029000135 Protein of unknown function (DUF1040); Region: DUF1040; cl01176 665029000136 serine/threonine protein kinase; Provisional; Region: PRK11768 665029000137 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 665029000138 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 665029000139 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 665029000140 catalytic residues [active] 665029000141 hinge region; other site 665029000142 alpha helical domain; other site 665029000143 DNA polymerase I; Provisional; Region: PRK05755 665029000144 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 665029000145 active site 665029000146 putative 5' ssDNA interaction site; other site 665029000147 metal binding site 3; metal-binding site 665029000148 metal binding site 1 [ion binding]; metal-binding site 665029000149 metal binding site 2 [ion binding]; metal-binding site 665029000150 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 665029000151 putative DNA binding site [nucleotide binding]; other site 665029000152 putative metal binding site [ion binding]; other site 665029000153 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 665029000154 active site 665029000155 catalytic site [active] 665029000156 substrate binding site [chemical binding]; other site 665029000157 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 665029000158 active site 665029000159 DNA binding site [nucleotide binding] 665029000160 catalytic site [active] 665029000161 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 665029000162 G1 box; other site 665029000163 GTP/Mg2+ binding site [chemical binding]; other site 665029000164 Switch I region; other site 665029000165 G2 box; other site 665029000166 G3 box; other site 665029000167 Switch II region; other site 665029000168 G4 box; other site 665029000169 G5 box; other site 665029000170 Der GTPase activator; Provisional; Region: PRK05244 665029000171 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 665029000172 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 665029000173 FeS/SAM binding site; other site 665029000174 HemN C-terminal domain; Region: HemN_C; pfam06969 665029000175 nitrogen regulation protein NR(I); Provisional; Region: glnG; PRK10923 665029000176 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 665029000177 active site 665029000178 phosphorylation site [posttranslational modification] 665029000179 intermolecular recognition site; other site 665029000180 dimerization interface [polypeptide binding]; other site 665029000181 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 665029000182 Walker A motif; other site 665029000183 ATP binding site [chemical binding]; other site 665029000184 Walker B motif; other site 665029000185 arginine finger; other site 665029000186 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 665029000187 nitrogen regulation protein NR(II); Provisional; Region: glnL; PRK11073 665029000188 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 665029000189 dimer interface [polypeptide binding]; other site 665029000190 phosphorylation site [posttranslational modification] 665029000191 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 665029000192 ATP binding site [chemical binding]; other site 665029000193 Mg2+ binding site [ion binding]; other site 665029000194 G-X-G motif; other site 665029000195 glutamine synthetase; Provisional; Region: glnA; PRK09469 665029000196 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 665029000197 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 665029000198 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 665029000199 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 665029000200 G1 box; other site 665029000201 putative GEF interaction site [polypeptide binding]; other site 665029000202 GTP/Mg2+ binding site [chemical binding]; other site 665029000203 Switch I region; other site 665029000204 G2 box; other site 665029000205 G3 box; other site 665029000206 Switch II region; other site 665029000207 G4 box; other site 665029000208 G5 box; other site 665029000209 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 665029000210 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 665029000211 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 665029000212 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 665029000213 motif II; other site 665029000214 hypothetical protein; Reviewed; Region: PRK01637 665029000215 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 665029000216 putative active site [active] 665029000217 dimerization interface [polypeptide binding]; other site 665029000218 putative tRNAtyr binding site [nucleotide binding]; other site 665029000219 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 665029000220 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 665029000221 Coenzyme A binding pocket [chemical binding]; other site 665029000222 Putative thioesterase (yiiD_Cterm); Region: YiiD_Cterm; pfam09500 665029000223 23S rRNA pseudouridine synthase F; Provisional; Region: PRK10475 665029000224 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 665029000225 RNA binding surface [nucleotide binding]; other site 665029000226 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 665029000227 probable active site [active] 665029000228 AsmA family; Region: AsmA; pfam05170 665029000229 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 665029000230 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 665029000231 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 665029000232 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 665029000233 generic binding surface II; other site 665029000234 ssDNA binding site; other site 665029000235 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 665029000236 ATP binding site [chemical binding]; other site 665029000237 putative Mg++ binding site [ion binding]; other site 665029000238 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 665029000239 nucleotide binding region [chemical binding]; other site 665029000240 ATP-binding site [chemical binding]; other site 665029000241 tRNA guanosine-2'-O-methyltransferase; Provisional; Region: PRK11081 665029000242 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 665029000243 SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105 665029000244 bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092 665029000245 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 665029000246 Zn2+ binding site [ion binding]; other site 665029000247 Mg2+ binding site [ion binding]; other site 665029000248 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 665029000249 synthetase active site [active] 665029000250 NTP binding site [chemical binding]; other site 665029000251 metal binding site [ion binding]; metal-binding site 665029000252 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 665029000253 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 665029000254 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 665029000255 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 665029000256 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 665029000257 catalytic site [active] 665029000258 G-X2-G-X-G-K; other site 665029000259 NAD-dependent DNA ligase LigB; Reviewed; Region: ligB; PRK08097 665029000260 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295 665029000261 nucleotide binding pocket [chemical binding]; other site 665029000262 K-X-D-G motif; other site 665029000263 catalytic site [active] 665029000264 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 665029000265 Predicted membrane protein [Function unknown]; Region: COG2860 665029000266 UPF0126 domain; Region: UPF0126; pfam03458 665029000267 UPF0126 domain; Region: UPF0126; pfam03458 665029000268 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 665029000269 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 665029000270 active site 665029000271 phosphorylation site [posttranslational modification] 665029000272 intermolecular recognition site; other site 665029000273 dimerization interface [polypeptide binding]; other site 665029000274 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 665029000275 DNA binding residues [nucleotide binding] 665029000276 dimerization interface [polypeptide binding]; other site 665029000277 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 665029000278 Major Facilitator Superfamily; Region: MFS_1; pfam07690 665029000279 putative substrate translocation pore; other site 665029000280 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 665029000281 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 665029000282 PhnA protein; Region: PhnA; pfam03831 665029000283 RT_Bac_retron_II: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_II; cd03487 665029000284 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 665029000285 putative active site [active] 665029000286 putative NTP binding site [chemical binding]; other site 665029000287 putative nucleic acid binding site [nucleotide binding]; other site 665029000288 sporadically distributed protein, TIGR04141 family; Region: TIGR04141 665029000289 HTH-like domain; Region: HTH_21; pfam13276 665029000290 Integrase core domain; Region: rve; pfam00665 665029000291 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 665029000292 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 665029000293 cofactor binding site; other site 665029000294 DNA binding site [nucleotide binding] 665029000295 substrate interaction site [chemical binding]; other site 665029000296 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 665029000297 Walker A motif; other site 665029000298 ATP binding site [chemical binding]; other site 665029000299 Walker B motif; other site 665029000300 arginine finger; other site 665029000301 potential protein location (hypothetical protein predicted by Glimmer/Critica) that overlaps protein (hypothetical protein predicted by Glimmer/Critica) 665029000302 potential protein location (hypothetical protein predicted by Glimmer/Critica) that overlaps protein (hypothetical protein predicted by Glimmer/Critica) 665029000303 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 665029000304 active site 665029000305 Int/Topo IB signature motif; other site 665029000306 hypothetical protein; Provisional; Region: PRK11820 665029000307 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 665029000308 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 665029000309 Protein of unknown function (DUF3574); Region: DUF3574; pfam12098 665029000310 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 665029000311 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 665029000312 Nucleoside recognition; Region: Gate; pfam07670 665029000313 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 665029000314 ribonuclease PH; Reviewed; Region: rph; PRK00173 665029000315 Ribonuclease PH; Region: RNase_PH_bact; cd11362 665029000316 hexamer interface [polypeptide binding]; other site 665029000317 active site 665029000318 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 665029000319 active site 665029000320 division inhibitor protein; Provisional; Region: slmA; PRK09480 665029000321 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 665029000322 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 665029000323 trimer interface [polypeptide binding]; other site 665029000324 active site 665029000325 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 665029000326 Flavoprotein; Region: Flavoprotein; pfam02441 665029000327 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 665029000328 hypothetical protein; Reviewed; Region: PRK00024 665029000329 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 665029000330 MPN+ (JAMM) motif; other site 665029000331 Zinc-binding site [ion binding]; other site 665029000332 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 665029000333 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 665029000334 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 665029000335 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 665029000336 DNA binding site [nucleotide binding] 665029000337 catalytic residue [active] 665029000338 H2TH interface [polypeptide binding]; other site 665029000339 putative catalytic residues [active] 665029000340 turnover-facilitating residue; other site 665029000341 intercalation triad [nucleotide binding]; other site 665029000342 8OG recognition residue [nucleotide binding]; other site 665029000343 putative reading head residues; other site 665029000344 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 665029000345 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 665029000346 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 665029000347 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 665029000348 active site 665029000349 (T/H)XGH motif; other site 665029000350 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 665029000351 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 665029000352 putative metal binding site; other site 665029000353 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 665029000354 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 665029000355 Glycosyl transferases group 1; Region: Glycos_transf_1; pfam00534 665029000356 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 665029000357 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 665029000358 putative active site [active] 665029000359 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 665029000360 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 665029000361 putative ADP-binding pocket [chemical binding]; other site 665029000362 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 665029000363 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 665029000364 lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK10422 665029000365 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 665029000366 putative active site [active] 665029000367 Putative catalytic domain of lipopolysaccharide biosynthesis protein WalW and its bacterial homologs; Region: CE4_WalW; cd10935 665029000368 putative active site [active] 665029000369 putative catalytic site [active] 665029000370 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 665029000371 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 665029000372 putative active site [active] 665029000373 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 665029000374 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 665029000375 active site 665029000376 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 665029000377 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 665029000378 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 665029000379 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 665029000380 putative active site [active] 665029000381 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 665029000382 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 665029000383 putative active site [active] 665029000384 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 665029000385 ADP-L-glycero-D-mannoheptose-6-epimerase; Provisional; Region: rfaD; PRK11150 665029000386 NADP binding site [chemical binding]; other site 665029000387 homopentamer interface [polypeptide binding]; other site 665029000388 substrate binding site [chemical binding]; other site 665029000389 active site 665029000390 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 665029000391 NodB motif; other site 665029000392 putative active site [active] 665029000393 putative catalytic site [active] 665029000394 Zn binding site [ion binding]; other site 665029000395 AmiB activator; Provisional; Region: PRK11637 665029000396 Peptidase family M23; Region: Peptidase_M23; pfam01551 665029000397 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 665029000398 active site residue [active] 665029000399 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 665029000400 GSH binding site [chemical binding]; other site 665029000401 catalytic residues [active] 665029000402 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557 665029000403 SecA binding site; other site 665029000404 Preprotein binding site; other site 665029000405 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 665029000406 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 665029000407 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 665029000408 serine acetyltransferase; Provisional; Region: cysE; PRK11132 665029000409 Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426 665029000410 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 665029000411 trimer interface [polypeptide binding]; other site 665029000412 active site 665029000413 substrate binding site [chemical binding]; other site 665029000414 CoA binding site [chemical binding]; other site 665029000415 putative rRNA methylase; Provisional; Region: PRK10358 665029000416 two-component sensor protein; Provisional; Region: cpxA; PRK09470 665029000417 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 665029000418 dimerization interface [polypeptide binding]; other site 665029000419 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 665029000420 dimer interface [polypeptide binding]; other site 665029000421 phosphorylation site [posttranslational modification] 665029000422 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 665029000423 ATP binding site [chemical binding]; other site 665029000424 Mg2+ binding site [ion binding]; other site 665029000425 G-X-G motif; other site 665029000426 DNA-binding transcriptional regulator CpxR; Provisional; Region: PRK10955 665029000427 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 665029000428 active site 665029000429 phosphorylation site [posttranslational modification] 665029000430 intermolecular recognition site; other site 665029000431 dimerization interface [polypeptide binding]; other site 665029000432 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 665029000433 DNA binding site [nucleotide binding] 665029000434 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 665029000435 dimer interface [polypeptide binding]; other site 665029000436 ferrous iron efflux protein F; Reviewed; Region: fieF; PRK09509 665029000437 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 665029000438 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 665029000439 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 665029000440 active site 665029000441 ADP/pyrophosphate binding site [chemical binding]; other site 665029000442 dimerization interface [polypeptide binding]; other site 665029000443 allosteric effector site; other site 665029000444 fructose-1,6-bisphosphate binding site; other site 665029000445 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 665029000446 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 665029000447 membrane-bound complex binding site; other site 665029000448 hinge residues; other site 665029000449 CDP-diacylglycerol pyrophosphatase; Provisional; Region: PRK05471 665029000450 inner membrane protein YhjD; Region: TIGR00766 665029000451 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 665029000452 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 665029000453 malate:quinone oxidoreductase; Validated; Region: PRK05257 665029000454 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 665029000455 potential protein location (hypothetical protein predicted by Glimmer/Critica) that overlaps protein (hypothetical protein predicted by Glimmer/Critica) 665029000456 potential protein location (hypothetical protein predicted by Glimmer/Critica) that overlaps protein (hypothetical protein predicted by Glimmer/Critica) 665029000457 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 665029000458 triosephosphate isomerase; Provisional; Region: PRK14567 665029000459 substrate binding site [chemical binding]; other site 665029000460 dimer interface [polypeptide binding]; other site 665029000461 catalytic triad [active] 665029000462 Protein of unknown function (DUF1454); Region: DUF1454; pfam07305 665029000463 Predicted membrane protein [Function unknown]; Region: COG3152 665029000464 ferredoxin-NADP reductase; Provisional; Region: PRK10926 665029000465 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 665029000466 FAD binding pocket [chemical binding]; other site 665029000467 FAD binding motif [chemical binding]; other site 665029000468 phosphate binding motif [ion binding]; other site 665029000469 beta-alpha-beta structure motif; other site 665029000470 NAD binding pocket [chemical binding]; other site 665029000471 DNA topoisomerase II large subunit; Provisional; Region: 39; PHA02569 665029000472 multidrug resistance protein D; Provisional; Region: emrD; PRK11652 665029000473 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 665029000474 putative substrate translocation pore; other site 665029000475 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 665029000476 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 665029000477 putative active site [active] 665029000478 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 665029000479 glycerol kinase; Provisional; Region: glpK; PRK00047 665029000480 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 665029000481 N- and C-terminal domain interface [polypeptide binding]; other site 665029000482 active site 665029000483 MgATP binding site [chemical binding]; other site 665029000484 catalytic site [active] 665029000485 metal binding site [ion binding]; metal-binding site 665029000486 glycerol binding site [chemical binding]; other site 665029000487 homotetramer interface [polypeptide binding]; other site 665029000488 homodimer interface [polypeptide binding]; other site 665029000489 FBP binding site [chemical binding]; other site 665029000490 protein IIAGlc interface [polypeptide binding]; other site 665029000491 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 665029000492 amphipathic channel; other site 665029000493 Asn-Pro-Ala signature motifs; other site 665029000494 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3074 665029000495 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 665029000496 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 665029000497 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 665029000498 Walker A motif; other site 665029000499 ATP binding site [chemical binding]; other site 665029000500 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 665029000501 Walker B motif; other site 665029000502 arginine finger; other site 665029000503 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 665029000504 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 665029000505 active site 665029000506 HslU subunit interaction site [polypeptide binding]; other site 665029000507 essential cell division protein FtsN; Provisional; Region: PRK10927 665029000508 cell division protein FtsN; Provisional; Region: PRK12757 665029000509 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 665029000510 DNA binding site [nucleotide binding] 665029000511 DNA-binding transcriptional regulator CytR; Provisional; Region: PRK11041 665029000512 domain linker motif; other site 665029000513 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 665029000514 dimerization interface [polypeptide binding]; other site 665029000515 ligand binding site [chemical binding]; other site 665029000516 primosome assembly protein PriA; Validated; Region: PRK05580 665029000517 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 665029000518 ATP binding site [chemical binding]; other site 665029000519 putative Mg++ binding site [ion binding]; other site 665029000520 helicase superfamily c-terminal domain; Region: HELICc; smart00490 665029000521 nucleotide binding region [chemical binding]; other site 665029000522 ATP-binding site [chemical binding]; other site 665029000523 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 665029000524 Met Repressor, MetJ. MetJ is a bacterial regulatory protein that uses S-adenosylmethionine (SAM) as a corepressor to regulate the production of Methionine. MetJ binds arrays of two to five adjacent copies of an eight base-pair 'metbox'...; Region: Met_repressor_MetJ; cd00490 665029000525 dimerization interface [polypeptide binding]; other site 665029000526 DNA binding site [nucleotide binding] 665029000527 corepressor binding sites; other site 665029000528 cystathionine gamma-synthase; Provisional; Region: PRK08045 665029000529 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 665029000530 homodimer interface [polypeptide binding]; other site 665029000531 substrate-cofactor binding pocket; other site 665029000532 pyridoxal 5'-phosphate binding site [chemical binding]; other site 665029000533 catalytic residue [active] 665029000534 bifunctional aspartate kinase II/homoserine dehydrogenase II; Provisional; Region: metL; PRK09466 665029000535 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 665029000536 putative catalytic residues [active] 665029000537 putative nucleotide binding site [chemical binding]; other site 665029000538 putative aspartate binding site [chemical binding]; other site 665029000539 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 665029000540 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 665029000541 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 665029000542 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 665029000543 FAD binding site [chemical binding]; other site 665029000544 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 665029000545 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 665029000546 acetylornithine deacetylase; Provisional; Region: PRK05111 665029000547 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 665029000548 metal binding site [ion binding]; metal-binding site 665029000549 putative dimer interface [polypeptide binding]; other site 665029000550 AAK_NAGK-NC: N-Acetyl-L-glutamate kinase - noncyclic (NAGK-NC) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of microbial arginine biosynthesis using the acetylated, noncyclic route of...; Region: AAK_NAGK-NC; cd04249 665029000551 nucleotide binding site [chemical binding]; other site 665029000552 N-acetyl-L-glutamate binding site [chemical binding]; other site 665029000553 argininosuccinate synthase; Provisional; Region: PRK13820 665029000554 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 665029000555 ANP binding site [chemical binding]; other site 665029000556 Substrate Binding Site II [chemical binding]; other site 665029000557 Substrate Binding Site I [chemical binding]; other site 665029000558 argininosuccinate lyase; Provisional; Region: PRK04833 665029000559 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 665029000560 active sites [active] 665029000561 tetramer interface [polypeptide binding]; other site 665029000562 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 665029000563 catalytic triad [active] 665029000564 dimer interface [polypeptide binding]; other site 665029000565 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 665029000566 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 665029000567 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 665029000568 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 665029000569 dimerization interface [polypeptide binding]; other site 665029000570 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 665029000571 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 665029000572 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 665029000573 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 665029000574 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 665029000575 hypothetical protein; Provisional; Region: PRK11056 665029000576 tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031 665029000577 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 665029000578 S-adenosylmethionine binding site [chemical binding]; other site 665029000579 glutamate racemase; Provisional; Region: PRK00865 665029000580 transcriptional regulator HdfR; Provisional; Region: PRK03601 665029000581 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 665029000582 LysR substrate binding domain; Region: LysR_substrate; pfam03466 665029000583 dimerization interface [polypeptide binding]; other site 665029000584 hypothetical protein; Provisional; Region: PRK11027 665029000585 putative ATP-dependent protease; Provisional; Region: PRK09862 665029000586 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 665029000587 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 665029000588 Walker A motif; other site 665029000589 ATP binding site [chemical binding]; other site 665029000590 Walker B motif; other site 665029000591 arginine finger; other site 665029000592 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 665029000593 acetolactate synthase 2 catalytic subunit; Reviewed; Region: PRK08978 665029000594 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 665029000595 PYR/PP interface [polypeptide binding]; other site 665029000596 dimer interface [polypeptide binding]; other site 665029000597 TPP binding site [chemical binding]; other site 665029000598 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 665029000599 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 665029000600 TPP-binding site [chemical binding]; other site 665029000601 dimer interface [polypeptide binding]; other site 665029000602 acetolactate synthase 2 regulatory subunit; Provisional; Region: ilvM; PRK11152 665029000603 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 665029000604 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 665029000605 homodimer interface [polypeptide binding]; other site 665029000606 substrate-cofactor binding pocket; other site 665029000607 catalytic residue [active] 665029000608 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 665029000609 threonine dehydratase; Reviewed; Region: PRK09224 665029000610 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 665029000611 tetramer interface [polypeptide binding]; other site 665029000612 pyridoxal 5'-phosphate binding site [chemical binding]; other site 665029000613 catalytic residue [active] 665029000614 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 665029000615 putative Ile/Val binding site [chemical binding]; other site 665029000616 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 665029000617 putative Ile/Val binding site [chemical binding]; other site 665029000618 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 665029000619 DNA-binding transcriptional regulator IlvY; Provisional; Region: PRK11716 665029000620 The C-terminal substrate binding of LysR-type transcriptional regulator IlvY, which activates the expression of ilvC gene that encoding acetohydroxy acid isomeroreductase for the biosynthesis of branched amino acids; contains the type 2 periplasmic bindin; Region: PBP2_IlvY; cd08430 665029000621 putative dimerization interface [polypeptide binding]; other site 665029000622 ketol-acid reductoisomerase; Validated; Region: PRK05225 665029000623 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 665029000624 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 665029000625 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 665029000626 peptidyl-prolyl cis-trans isomerase C; Provisional; Region: PRK15441 665029000627 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 665029000628 ATP-dependent DNA helicase Rep; Provisional; Region: PRK10919 665029000629 Part of AAA domain; Region: AAA_19; pfam13245 665029000630 Family description; Region: UvrD_C_2; pfam13538 665029000631 guanosine pentaphosphate phosphohydrolase; Provisional; Region: PRK11031 665029000632 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 665029000633 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 665029000634 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 665029000635 ATP binding site [chemical binding]; other site 665029000636 Mg++ binding site [ion binding]; other site 665029000637 motif III; other site 665029000638 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 665029000639 nucleotide binding region [chemical binding]; other site 665029000640 ATP-binding site [chemical binding]; other site 665029000641 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 665029000642 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 665029000643 catalytic residues [active] 665029000644 transcription termination factor Rho; Provisional; Region: rho; PRK09376 665029000645 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 665029000646 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 665029000647 RNA binding site [nucleotide binding]; other site 665029000648 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 665029000649 multimer interface [polypeptide binding]; other site 665029000650 Walker A motif; other site 665029000651 ATP binding site [chemical binding]; other site 665029000652 Walker B motif; other site 665029000653 undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase; Provisional; Region: PRK15119 665029000654 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 665029000655 Mg++ binding site [ion binding]; other site 665029000656 putative catalytic motif [active] 665029000657 substrate binding site [chemical binding]; other site 665029000658 lipopolysaccharide biosynthesis protein WzzE; Provisional; Region: PRK11638 665029000659 Chain length determinant protein; Region: Wzz; pfam02706 665029000660 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 665029000661 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 665029000662 active site 665029000663 homodimer interface [polypeptide binding]; other site 665029000664 UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064 665029000665 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 665029000666 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 665029000667 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 665029000668 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 665029000669 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 665029000670 NAD binding site [chemical binding]; other site 665029000671 substrate binding site [chemical binding]; other site 665029000672 homodimer interface [polypeptide binding]; other site 665029000673 active site 665029000674 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 665029000675 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 665029000676 substrate binding site; other site 665029000677 tetramer interface; other site 665029000678 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 665029000679 Coenzyme A binding pocket [chemical binding]; other site 665029000680 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 665029000681 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 665029000682 inhibitor-cofactor binding pocket; inhibition site 665029000683 pyridoxal 5'-phosphate binding site [chemical binding]; other site 665029000684 catalytic residue [active] 665029000685 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_10; cd13125 665029000686 4-alpha-L-fucosyltransferase; Provisional; Region: PRK02797 665029000687 putative common antigen polymerase; Provisional; Region: PRK02975 665029000688 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 665029000689 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 665029000690 putative protoheme IX biogenesis protein; Provisional; Region: PRK10747 665029000691 HemY protein N-terminus; Region: HemY_N; pfam07219 665029000692 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 665029000693 TPR motif; other site 665029000694 binding surface 665029000695 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 665029000696 Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemX; COG2959 665029000697 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 665029000698 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 665029000699 active site 665029000700 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 665029000701 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 665029000702 domain interfaces; other site 665029000703 active site 665029000704 adenylate cyclase; Provisional; Region: cyaA; PRK09450 665029000705 Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633 665029000706 Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295 665029000707 Prokaryotic lipoprotein-attachment site; Region: LPAM_2; cl02361 665029000708 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 665029000709 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 665029000710 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 665029000711 hypothetical protein; Provisional; Region: PRK10963 665029000712 Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973 665029000713 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 665029000714 active site 665029000715 DNA binding site [nucleotide binding] 665029000716 Int/Topo IB signature motif; other site 665029000717 flavin mononucleotide phosphatase; Provisional; Region: PRK10748 665029000718 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 665029000719 motif II; other site 665029000720 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 665029000721 Part of AAA domain; Region: AAA_19; pfam13245 665029000722 Family description; Region: UvrD_C_2; pfam13538 665029000723 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 665029000724 Escherichia coli Mg2+ transporter CorA_like subgroup; Region: EcCorA-like_1; cd12835 665029000725 Cl binding site [ion binding]; other site 665029000726 oligomer interface [polypeptide binding]; other site 665029000727 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 665029000728 CoenzymeA binding site [chemical binding]; other site 665029000729 subunit interaction site [polypeptide binding]; other site 665029000730 PHB binding site; other site 665029000731 The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541 665029000732 dimerization interface [polypeptide binding]; other site 665029000733 substrate binding site [chemical binding]; other site 665029000734 active site 665029000735 calcium binding site [ion binding]; other site 665029000736 ATP-dependent DNA helicase RecQ; Provisional; Region: PRK11057 665029000737 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 665029000738 ATP binding site [chemical binding]; other site 665029000739 putative Mg++ binding site [ion binding]; other site 665029000740 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 665029000741 nucleotide binding region [chemical binding]; other site 665029000742 ATP-binding site [chemical binding]; other site 665029000743 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 665029000744 Helicase and RNase D C-terminal; Region: HRDC; smart00341 665029000745 homoserine/homoserine lactone efflux protein; Provisional; Region: rhtB; PRK10520 665029000746 lysophospholipase L2; Provisional; Region: PRK10749 665029000747 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 665029000748 putative hydrolase; Provisional; Region: PRK10976 665029000749 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 665029000750 active site 665029000751 motif I; other site 665029000752 motif II; other site 665029000753 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 665029000754 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 665029000755 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 665029000756 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 665029000757 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807 665029000758 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 665029000759 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 665029000760 DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421 665029000761 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 665029000762 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 665029000763 putative dimerization interface [polypeptide binding]; other site 665029000764 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 665029000765 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 665029000766 THF binding site; other site 665029000767 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 665029000768 substrate binding site [chemical binding]; other site 665029000769 THF binding site; other site 665029000770 zinc-binding site [ion binding]; other site 665029000771 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 665029000772 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 665029000773 uridine phosphorylase; Provisional; Region: PRK11178 665029000774 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 665029000775 RmuC family; Region: RmuC; pfam02646 665029000776 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 665029000777 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 665029000778 S-adenosylmethionine binding site [chemical binding]; other site 665029000779 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 665029000780 SCP-2 sterol transfer family; Region: SCP2; pfam02036 665029000781 putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750 665029000782 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 665029000783 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 665029000784 sec-independent translocase; Provisional; Region: PRK01770 665029000785 twin-arginine protein translocation system subunit TatC; Provisional; Region: PRK10921 665029000786 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 665029000787 active site 665029000788 transcriptional activator RfaH; Provisional; Region: rfaH; PRK09014 665029000789 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), RfaH; Region: NGN_SP_RfaH; cd09892 665029000790 KOW: an acronym for the authors' surnames (Kyrpides, Ouzounis and Woese); Region: KOW; cl00354 665029000791 3-octaprenyl-4-hydroxybenzoate decarboxylase; Provisional; Region: PRK10922 665029000792 FMN reductase; Validated; Region: fre; PRK08051 665029000793 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 665029000794 FAD binding pocket [chemical binding]; other site 665029000795 FAD binding motif [chemical binding]; other site 665029000796 phosphate binding motif [ion binding]; other site 665029000797 beta-alpha-beta structure motif; other site 665029000798 NAD binding pocket [chemical binding]; other site 665029000799 3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947 665029000800 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 665029000801 dimer interface [polypeptide binding]; other site 665029000802 active site 665029000803 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 665029000804 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 665029000805 substrate binding site [chemical binding]; other site 665029000806 oxyanion hole (OAH) forming residues; other site 665029000807 trimer interface [polypeptide binding]; other site 665029000808 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 665029000809 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 665029000810 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 665029000811 proline dipeptidase; Provisional; Region: PRK13607 665029000812 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 665029000813 active site 665029000814 hypothetical protein; Provisional; Region: PRK11568 665029000815 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 665029000816 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 665029000817 potassium transporter; Provisional; Region: PRK10750 665029000818 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 665029000819 protoporphyrinogen oxidase; Provisional; Region: hemG; PRK11104 665029000820 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 665029000821 FAD binding domain; Region: FAD_binding_4; pfam01565 665029000822 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 665029000823 Biotin operon repressor [Transcription]; Region: BirA; COG1654 665029000824 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 665029000825 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 665029000826 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 665029000827 pantothenate kinase; Provisional; Region: PRK05439 665029000828 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 665029000829 ATP-binding site [chemical binding]; other site 665029000830 CoA-binding site [chemical binding]; other site 665029000831 Mg2+-binding site [ion binding]; other site 665029000832 elongation factor Tu; Reviewed; Region: PRK00049 665029000833 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 665029000834 G1 box; other site 665029000835 GEF interaction site [polypeptide binding]; other site 665029000836 GTP/Mg2+ binding site [chemical binding]; other site 665029000837 Switch I region; other site 665029000838 G2 box; other site 665029000839 G3 box; other site 665029000840 Switch II region; other site 665029000841 G4 box; other site 665029000842 G5 box; other site 665029000843 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 665029000844 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 665029000845 Antibiotic Binding Site [chemical binding]; other site 665029000846 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 665029000847 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 665029000848 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 665029000849 putative homodimer interface [polypeptide binding]; other site 665029000850 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 665029000851 heterodimer interface [polypeptide binding]; other site 665029000852 homodimer interface [polypeptide binding]; other site 665029000853 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 665029000854 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 665029000855 23S rRNA interface [nucleotide binding]; other site 665029000856 L7/L12 interface [polypeptide binding]; other site 665029000857 putative thiostrepton binding site; other site 665029000858 L25 interface [polypeptide binding]; other site 665029000859 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 665029000860 mRNA/rRNA interface [nucleotide binding]; other site 665029000861 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 665029000862 23S rRNA interface [nucleotide binding]; other site 665029000863 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 665029000864 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 665029000865 core dimer interface [polypeptide binding]; other site 665029000866 peripheral dimer interface [polypeptide binding]; other site 665029000867 L10 interface [polypeptide binding]; other site 665029000868 L11 interface [polypeptide binding]; other site 665029000869 putative EF-Tu interaction site [polypeptide binding]; other site 665029000870 putative EF-G interaction site [polypeptide binding]; other site 665029000871 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 665029000872 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 665029000873 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 665029000874 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 665029000875 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 665029000876 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 665029000877 RPB3 interaction site [polypeptide binding]; other site 665029000878 RPB1 interaction site [polypeptide binding]; other site 665029000879 RPB11 interaction site [polypeptide binding]; other site 665029000880 RPB10 interaction site [polypeptide binding]; other site 665029000881 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 665029000882 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 665029000883 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 665029000884 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 665029000885 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 665029000886 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 665029000887 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 665029000888 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 665029000889 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 665029000890 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 665029000891 DNA binding site [nucleotide binding] 665029000892 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 665029000893 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 665029000894 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 665029000895 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 665029000896 fimbrial protein PefA; Provisional; Region: PRK15214 665029000897 fimbrial outer membrane usher protein PefC; Provisional; Region: PRK15213 665029000898 PapC N-terminal domain; Region: PapC_N; pfam13954 665029000899 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 665029000900 fimbrial chaperone protein PefD; Provisional; Region: PRK15211 665029000901 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 665029000902 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 665029000903 Fimbrial, major and minor subunit; Region: Fimbrial_K88; pfam02432 665029000904 Fimbrial, major and minor subunit; Region: Fimbrial_K88; pfam02432 665029000905 Fimbrial, major and minor subunit; Region: Fimbrial_K88; pfam02432 665029000906 outer membrane protease; Reviewed; Region: PRK10993 665029000907 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 665029000908 thiamine phosphate binding site [chemical binding]; other site 665029000909 active site 665029000910 pyrophosphate binding site [ion binding]; other site 665029000911 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 665029000912 ThiC-associated domain; Region: ThiC-associated; pfam13667 665029000913 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 665029000914 anti-RNA polymerase sigma 70 factor; Provisional; Region: PRK11718 665029000915 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 665029000916 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 665029000917 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 665029000918 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 665029000919 putative NADH binding site [chemical binding]; other site 665029000920 putative active site [active] 665029000921 nudix motif; other site 665029000922 putative metal binding site [ion binding]; other site 665029000923 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 665029000924 substrate binding site [chemical binding]; other site 665029000925 active site 665029000926 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 665029000927 Active_site [active] 665029000928 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3068 665029000929 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 665029000930 IHF dimer interface [polypeptide binding]; other site 665029000931 IHF - DNA interface [nucleotide binding]; other site 665029000932 Protein of unknown function (DUF1481); Region: DUF1481; pfam07356 665029000933 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 665029000934 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 665029000935 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 665029000936 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 665029000937 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 665029000938 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 665029000939 purine monophosphate binding site [chemical binding]; other site 665029000940 dimer interface [polypeptide binding]; other site 665029000941 putative catalytic residues [active] 665029000942 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 665029000943 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 665029000944 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 665029000945 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 665029000946 Walker A/P-loop; other site 665029000947 ATP binding site [chemical binding]; other site 665029000948 Q-loop/lid; other site 665029000949 ABC transporter signature motif; other site 665029000950 Walker B; other site 665029000951 D-loop; other site 665029000952 H-loop/switch region; other site 665029000953 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 665029000954 dimer interface [polypeptide binding]; other site 665029000955 conserved gate region; other site 665029000956 putative PBP binding loops; other site 665029000957 ABC-ATPase subunit interface; other site 665029000958 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597 665029000959 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 665029000960 conserved gate region; other site 665029000961 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 665029000962 dimer interface [polypeptide binding]; other site 665029000963 conserved gate region; other site 665029000964 putative PBP binding loops; other site 665029000965 ABC-ATPase subunit interface; other site 665029000966 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 665029000967 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 665029000968 substrate binding pocket [chemical binding]; other site 665029000969 membrane-bound complex binding site; other site 665029000970 hinge residues; other site 665029000971 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 665029000972 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 665029000973 putative acyl-acceptor binding pocket; other site 665029000974 Factor for inversion stimulation Fis, transcriptional activator [Transcription / DNA replication, recombination, and repair]; Region: Fis; COG2901 665029000975 global DNA-binding transcriptional dual regulator Fis; Provisional; Region: fis; PRK00430 665029000976 tRNA-dihydrouridine synthase B; Provisional; Region: PRK10415 665029000977 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 665029000978 FMN binding site [chemical binding]; other site 665029000979 active site 665029000980 catalytic residues [active] 665029000981 substrate binding site [chemical binding]; other site 665029000982 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 665029000983 Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; Region: SLC5sbd_PanF; cd10327 665029000984 Na binding site [ion binding]; other site 665029000985 hypothetical protein; Provisional; Region: PRK10633 665029000986 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 665029000987 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 665029000988 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 665029000989 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 665029000990 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 665029000991 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 665029000992 carboxyltransferase (CT) interaction site; other site 665029000993 biotinylation site [posttranslational modification]; other site 665029000994 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 665029000995 Dehydroquinase class II; Region: DHquinase_II; pfam01220 665029000996 active site 665029000997 trimer interface [polypeptide binding]; other site 665029000998 dimer interface [polypeptide binding]; other site 665029000999 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 665029001000 TMAO/DMSO reductase; Reviewed; Region: PRK05363 665029001001 YedY_like molybdopterin cofactor (Moco) binding domain, a subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. Escherichia coli YedY has been propsed to form a heterodimer, consisting of a soluble catalytic subunit termed YedY; Region: YedY_like_Moco; cd02107 665029001002 Moco binding site; other site 665029001003 metal coordination site [ion binding]; other site 665029001004 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 665029001005 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 665029001006 NADP binding site [chemical binding]; other site 665029001007 dimer interface [polypeptide binding]; other site 665029001008 regulatory protein CsrD; Provisional; Region: PRK11059 665029001009 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 665029001010 metal binding site [ion binding]; metal-binding site 665029001011 active site 665029001012 I-site; other site 665029001013 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 665029001014 rod shape-determining protein MreB; Provisional; Region: PRK13927 665029001015 MreB and similar proteins; Region: MreB_like; cd10225 665029001016 nucleotide binding site [chemical binding]; other site 665029001017 Mg binding site [ion binding]; other site 665029001018 putative protofilament interaction site [polypeptide binding]; other site 665029001019 RodZ interaction site [polypeptide binding]; other site 665029001020 rod shape-determining protein MreC; Region: mreC; TIGR00219 665029001021 rod shape-determining protein MreC; Region: MreC; pfam04085 665029001022 rod shape-determining protein MreD; Provisional; Region: PRK11060 665029001023 Maf-like protein; Region: Maf; pfam02545 665029001024 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 665029001025 active site 665029001026 dimer interface [polypeptide binding]; other site 665029001027 ribonuclease G; Provisional; Region: PRK11712 665029001028 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 665029001029 homodimer interface [polypeptide binding]; other site 665029001030 oligonucleotide binding site [chemical binding]; other site 665029001031 hypothetical protein; Provisional; Region: PRK10899 665029001032 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 665029001033 protease TldD; Provisional; Region: tldD; PRK10735 665029001034 transcriptional regulator; Provisional; Region: PRK10632 665029001035 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 665029001036 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 665029001037 putative effector binding pocket; other site 665029001038 dimerization interface [polypeptide binding]; other site 665029001039 efflux system membrane protein; Provisional; Region: PRK11594 665029001040 p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559 665029001041 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 665029001042 HlyD family secretion protein; Region: HlyD_3; pfam13437 665029001043 p-hydroxybenzoic acid efflux subunit AaeB; Provisional; Region: PRK10631 665029001044 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 665029001045 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 665029001046 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 665029001047 arginine repressor; Provisional; Region: PRK05066 665029001048 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 665029001049 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 665029001050 malate dehydrogenase; Provisional; Region: PRK05086 665029001051 Glyoxysomal and mitochondrial malate dehydrogenases; Region: MDH_glyoxysomal_mitochondrial; cd01337 665029001052 NAD binding site [chemical binding]; other site 665029001053 dimerization interface [polypeptide binding]; other site 665029001054 Substrate binding site [chemical binding]; other site 665029001055 serine endoprotease; Provisional; Region: PRK10898 665029001056 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 665029001057 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 665029001058 protein binding site [polypeptide binding]; other site 665029001059 serine endoprotease; Provisional; Region: PRK10139 665029001060 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 665029001061 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 665029001062 protein binding site [polypeptide binding]; other site 665029001063 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 665029001064 protein binding site [polypeptide binding]; other site 665029001065 hypothetical protein; Provisional; Region: PRK11677 665029001066 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3105 665029001067 Predicted ATPase [General function prediction only]; Region: COG1485 665029001068 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 665029001069 23S rRNA interface [nucleotide binding]; other site 665029001070 L3 interface [polypeptide binding]; other site 665029001071 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 665029001072 stringent starvation protein A; Provisional; Region: sspA; PRK09481 665029001073 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 665029001074 C-terminal domain interface [polypeptide binding]; other site 665029001075 putative GSH binding site (G-site) [chemical binding]; other site 665029001076 dimer interface [polypeptide binding]; other site 665029001077 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 665029001078 dimer interface [polypeptide binding]; other site 665029001079 N-terminal domain interface [polypeptide binding]; other site 665029001080 ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798 665029001081 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 665029001082 Flavodoxin; Region: Flavodoxin_1; pfam00258 665029001083 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 665029001084 FAD binding pocket [chemical binding]; other site 665029001085 FAD binding motif [chemical binding]; other site 665029001086 catalytic residues [active] 665029001087 NAD binding pocket [chemical binding]; other site 665029001088 phosphate binding motif [ion binding]; other site 665029001089 beta-alpha-beta structure motif; other site 665029001090 Glutamate synthase domain 1 [Amino acid transport and metabolism]; Region: GltB; COG0067 665029001091 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 665029001092 active site 665029001093 dimer interface [polypeptide binding]; other site 665029001094 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 665029001095 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 665029001096 active site 665029001097 FMN binding site [chemical binding]; other site 665029001098 substrate binding site [chemical binding]; other site 665029001099 3Fe-4S cluster binding site [ion binding]; other site 665029001100 GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS), in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cl00239 665029001101 domain_subunit interface; other site 665029001102 aerobic respiration control sensor protein ArcB; Provisional; Region: PRK11091 665029001103 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 665029001104 putative active site [active] 665029001105 heme pocket [chemical binding]; other site 665029001106 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 665029001107 dimer interface [polypeptide binding]; other site 665029001108 phosphorylation site [posttranslational modification] 665029001109 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 665029001110 ATP binding site [chemical binding]; other site 665029001111 Mg2+ binding site [ion binding]; other site 665029001112 G-X-G motif; other site 665029001113 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 665029001114 active site 665029001115 phosphorylation site [posttranslational modification] 665029001116 intermolecular recognition site; other site 665029001117 dimerization interface [polypeptide binding]; other site 665029001118 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 665029001119 putative binding surface; other site 665029001120 active site 665029001121 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 665029001122 Transglycosylase; Region: Transgly; cl17702 665029001123 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 665029001124 dimerization domain swap beta strand [polypeptide binding]; other site 665029001125 regulatory protein interface [polypeptide binding]; other site 665029001126 active site 665029001127 regulatory phosphorylation site [posttranslational modification]; other site 665029001128 P-loop ATPase protein family; Region: ATP_bind_2; cl15794 665029001129 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 665029001130 active site 665029001131 phosphorylation site [posttranslational modification] 665029001132 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 665029001133 30S subunit binding site; other site 665029001134 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 665029001135 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 665029001136 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 665029001137 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 665029001138 lipopolysaccharide ABC transporter ATP-binding protein; Provisional; Region: PRK10895 665029001139 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 665029001140 Walker A/P-loop; other site 665029001141 ATP binding site [chemical binding]; other site 665029001142 Q-loop/lid; other site 665029001143 ABC transporter signature motif; other site 665029001144 Walker B; other site 665029001145 D-loop; other site 665029001146 H-loop/switch region; other site 665029001147 lipopolysaccharide transport periplasmic protein LptA; Provisional; Region: PRK10894 665029001148 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 665029001149 lipopolysaccharide exporter periplasmic protein; Provisional; Region: PRK10893 665029001150 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 665029001151 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase; Provisional; Region: PRK09484 665029001152 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 665029001153 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 665029001154 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 665029001155 putative active site [active] 665029001156 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 665029001157 putative calcium/sodium:proton antiporter; Provisional; Region: PRK10734 665029001158 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 665029001159 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 665029001160 putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831 665029001161 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 665029001162 Walker A/P-loop; other site 665029001163 ATP binding site [chemical binding]; other site 665029001164 Q-loop/lid; other site 665029001165 ABC transporter signature motif; other site 665029001166 Walker B; other site 665029001167 D-loop; other site 665029001168 H-loop/switch region; other site 665029001169 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 665029001170 conserved hypothetical integral membrane protein; Region: TIGR00056 665029001171 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 665029001172 mce related protein; Region: MCE; pfam02470 665029001173 ABC transporter periplasmic binding protein MlaC; Provisional; Region: PRK15117 665029001174 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 665029001175 anti sigma factor interaction site; other site 665029001176 regulatory phosphorylation site [posttranslational modification]; other site 665029001177 Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007 665029001178 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 665029001179 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 665029001180 hinge; other site 665029001181 active site 665029001182 Winged helix-turn-helix DNA-binding; Region: HTH_35; pfam13693 665029001183 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 665029001184 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 665029001185 substrate binding pocket [chemical binding]; other site 665029001186 chain length determination region; other site 665029001187 substrate-Mg2+ binding site; other site 665029001188 catalytic residues [active] 665029001189 aspartate-rich region 1; other site 665029001190 active site lid residues [active] 665029001191 aspartate-rich region 2; other site 665029001192 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 665029001193 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 665029001194 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 665029001195 GTPase CgtA; Reviewed; Region: obgE; PRK12298 665029001196 GTP1/OBG; Region: GTP1_OBG; pfam01018 665029001197 Obg GTPase; Region: Obg; cd01898 665029001198 G1 box; other site 665029001199 GTP/Mg2+ binding site [chemical binding]; other site 665029001200 Switch I region; other site 665029001201 G2 box; other site 665029001202 G3 box; other site 665029001203 Switch II region; other site 665029001204 G4 box; other site 665029001205 G5 box; other site 665029001206 sensor protein BasS/PmrB; Provisional; Region: PRK10755 665029001207 HAMP domain; Region: HAMP; pfam00672 665029001208 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 665029001209 dimer interface [polypeptide binding]; other site 665029001210 phosphorylation site [posttranslational modification] 665029001211 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 665029001212 ATP binding site [chemical binding]; other site 665029001213 Mg2+ binding site [ion binding]; other site 665029001214 G-X-G motif; other site 665029001215 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 665029001216 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 665029001217 active site 665029001218 phosphorylation site [posttranslational modification] 665029001219 intermolecular recognition site; other site 665029001220 dimerization interface [polypeptide binding]; other site 665029001221 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 665029001222 DNA binding site [nucleotide binding] 665029001223 D-alanyl-D-alanine carboxypeptidase/endopeptidase; Provisional; Region: PRK11113 665029001224 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 665029001225 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 665029001226 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 665029001227 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 665029001228 RNA-binding protein YhbY; Provisional; Region: PRK10343 665029001229 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 665029001230 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 665029001231 S-adenosylmethionine binding site [chemical binding]; other site 665029001232 ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733 665029001233 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 665029001234 Walker A motif; other site 665029001235 ATP binding site [chemical binding]; other site 665029001236 Walker B motif; other site 665029001237 arginine finger; other site 665029001238 Peptidase family M41; Region: Peptidase_M41; pfam01434 665029001239 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 665029001240 dihydropteroate synthase; Region: DHPS; TIGR01496 665029001241 substrate binding pocket [chemical binding]; other site 665029001242 dimer interface [polypeptide binding]; other site 665029001243 inhibitor binding site; inhibition site 665029001244 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 665029001245 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 665029001246 active site 665029001247 substrate binding site [chemical binding]; other site 665029001248 metal binding site [ion binding]; metal-binding site 665029001249 Preprotein translocase SecG subunit; Region: SecG; pfam03840 665029001250 ribosome maturation protein RimP; Reviewed; Region: PRK00092 665029001251 Sm and related proteins; Region: Sm_like; cl00259 665029001252 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 665029001253 putative oligomer interface [polypeptide binding]; other site 665029001254 putative RNA binding site [nucleotide binding]; other site 665029001255 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 665029001256 NusA N-terminal domain; Region: NusA_N; pfam08529 665029001257 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 665029001258 RNA binding site [nucleotide binding]; other site 665029001259 homodimer interface [polypeptide binding]; other site 665029001260 NusA-like KH domain; Region: KH_5; pfam13184 665029001261 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 665029001262 G-X-X-G motif; other site 665029001263 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 665029001264 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 665029001265 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 665029001266 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 665029001267 translation initiation factor IF-2; Region: IF-2; TIGR00487 665029001268 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 665029001269 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 665029001270 G1 box; other site 665029001271 putative GEF interaction site [polypeptide binding]; other site 665029001272 GTP/Mg2+ binding site [chemical binding]; other site 665029001273 Switch I region; other site 665029001274 G2 box; other site 665029001275 G3 box; other site 665029001276 Switch II region; other site 665029001277 G4 box; other site 665029001278 G5 box; other site 665029001279 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 665029001280 Translation-initiation factor 2; Region: IF-2; pfam11987 665029001281 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 665029001282 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 665029001283 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 665029001284 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 665029001285 RNA binding site [nucleotide binding]; other site 665029001286 active site 665029001287 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 665029001288 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 665029001289 16S/18S rRNA binding site [nucleotide binding]; other site 665029001290 S13e-L30e interaction site [polypeptide binding]; other site 665029001291 25S rRNA binding site [nucleotide binding]; other site 665029001292 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 665029001293 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 665029001294 RNase E interface [polypeptide binding]; other site 665029001295 trimer interface [polypeptide binding]; other site 665029001296 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 665029001297 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 665029001298 RNase E interface [polypeptide binding]; other site 665029001299 trimer interface [polypeptide binding]; other site 665029001300 active site 665029001301 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 665029001302 RNA binding site [nucleotide binding]; other site 665029001303 domain interface; other site 665029001304 lipoprotein NlpI; Provisional; Region: PRK11189 665029001305 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 665029001306 binding surface 665029001307 TPR motif; other site 665029001308 ATP-dependent RNA helicase DeaD; Provisional; Region: PRK11634 665029001309 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 665029001310 ATP binding site [chemical binding]; other site 665029001311 Mg++ binding site [ion binding]; other site 665029001312 motif III; other site 665029001313 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 665029001314 nucleotide binding region [chemical binding]; other site 665029001315 ATP-binding site [chemical binding]; other site 665029001316 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 665029001317 putative RNA binding site [nucleotide binding]; other site 665029001318 hypothetical protein; Provisional; Region: PRK10508 665029001319 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 665029001320 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 665029001321 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 665029001322 Coenzyme A binding pocket [chemical binding]; other site 665029001323 Predicted membrane protein [Function unknown]; Region: COG3766 665029001324 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 665029001325 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 665029001326 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 665029001327 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 665029001328 FeS/SAM binding site; other site 665029001329 anaerobic ribonucleoside-triphosphate reductase; Region: NrdD; TIGR02487 665029001330 Class III ribonucleotide reductase; Region: RNR_III; cd01675 665029001331 effector binding site; other site 665029001332 active site 665029001333 Zn binding site [ion binding]; other site 665029001334 glycine loop; other site 665029001335 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 665029001336 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 665029001337 ATP binding site [chemical binding]; other site 665029001338 putative Mg++ binding site [ion binding]; other site 665029001339 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 665029001340 nucleotide binding region [chemical binding]; other site 665029001341 ATP-binding site [chemical binding]; other site 665029001342 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 665029001343 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 665029001344 Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides; Region: GH20_hexosaminidase; cl02948 665029001345 active site 665029001346 Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides; Region: GH20_hexosaminidase; cl02948 665029001347 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 665029001348 homotrimer interaction site [polypeptide binding]; other site 665029001349 putative active site [active] 665029001350 aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893 665029001351 Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948 665029001352 Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748 665029001353 Aspartate carbamoyltransferase, catalytic chain [Nucleotide transport and metabolism]; Region: PyrB; COG0540 665029001354 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 665029001355 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 665029001356 ornithine carbamoyltransferase subunit I; Provisional; Region: PRK03515 665029001357 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 665029001358 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 665029001359 RNase E inhibitor protein; Provisional; Region: PRK11191 665029001360 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 665029001361 Coenzyme A binding pocket [chemical binding]; other site 665029001362 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 665029001363 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 665029001364 active site 665029001365 regulatory protein UhpC; Provisional; Region: PRK11663 665029001366 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 665029001367 putative substrate translocation pore; other site 665029001368 PAS fold; Region: PAS_4; pfam08448 665029001369 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 665029001370 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 665029001371 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 665029001372 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 665029001373 HIGH motif; other site 665029001374 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 665029001375 active site 665029001376 KMSKS motif; other site 665029001377 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 665029001378 tRNA binding surface [nucleotide binding]; other site 665029001379 anticodon binding site; other site 665029001380 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 665029001381 DNA polymerase III subunit chi; Validated; Region: PRK05728 665029001382 multifunctional aminopeptidase A; Provisional; Region: PRK00913 665029001383 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 665029001384 interface (dimer of trimers) [polypeptide binding]; other site 665029001385 Substrate-binding/catalytic site; other site 665029001386 Zn-binding sites [ion binding]; other site 665029001387 lipopolysaccharide ABC transporter permease LptF; Provisional; Region: PRK15120 665029001388 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 665029001389 lipopolysaccharide ABC transporter permease; Provisional; Region: PRK15071 665029001390 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 665029001391 Predicted membrane protein [Function unknown]; Region: COG2733 665029001392 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 665029001393 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 665029001394 Walker A motif; other site 665029001395 ATP binding site [chemical binding]; other site 665029001396 hypothetical protein; Provisional; Region: PRK11667 665029001397 integrase; Provisional; Region: PRK09692 665029001398 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 665029001399 active site 665029001400 Int/Topo IB signature motif; other site 665029001401 DNA phosphorothioation-dependent restriction protein DptF; Region: dnd_assoc_3; TIGR03238 665029001402 DNA phosphorothioation-dependent restriction protein DptG; Region: dnd_assoc_1; TIGR03236 665029001403 DNA phosphorothioation-dependent restriction protein DptH; Region: dnd_assoc_2; TIGR03237 665029001404 DNA phosphorothioation-dependent restriction protein DptH; Region: dnd_assoc_2; TIGR03237 665029001405 AAA-like domain; Region: AAA_10; pfam12846 665029001406 Restriction endonuclease; Region: Mrr_cat; pfam04471 665029001407 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 665029001408 Methyltransferase domain; Region: Methyltransf_23; pfam13489 665029001409 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 665029001410 S-adenosylmethionine binding site [chemical binding]; other site 665029001411 DNA sulfur modification protein DndD; Region: DNA_S_dndD; TIGR03185 665029001412 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 665029001413 Walker A/P-loop; other site 665029001414 ATP binding site [chemical binding]; other site 665029001415 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 665029001416 ABC transporter signature motif; other site 665029001417 Walker B; other site 665029001418 D-loop; other site 665029001419 H-loop/switch region; other site 665029001420 hypothetical protein; Provisional; Region: PRK06850 665029001421 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 665029001422 Active Sites [active] 665029001423 DNA-sulfur modification-associated; Region: DndB; pfam14072 665029001424 DGQHR domain; Region: DGQHR; TIGR03187 665029001425 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 665029001426 Domain of unknown function (DUF932); Region: DUF932; cl12129 665029001427 Domain of unknown function (DUF932); Region: DUF932; cl12129 665029001428 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 665029001429 MPN+ (JAMM) motif; other site 665029001430 Zinc-binding site [ion binding]; other site 665029001431 YagB/YeeU/YfjZ family; Region: YagB_YeeU_YfjZ; pfam06154 665029001432 Protein of unknown function (DUF1219); Region: DUF1219; pfam06755 665029001433 Methyltransferase domain; Region: Methyltransf_27; pfam13708 665029001434 Predicted transcriptional regulator [Transcription]; Region: COG3905 665029001435 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 665029001436 Transposase; Region: HTH_Tnp_1; pfam01527 665029001437 Integrase core domain; Region: rve_3; cl15866 665029001438 Part of AAA domain; Region: AAA_19; pfam13245 665029001439 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 665029001440 AAA domain; Region: AAA_12; pfam13087 665029001441 hypothetical protein; Provisional; Region: PRK10396 665029001442 yecA family protein; Region: ygfB_yecA; TIGR02292 665029001443 NLPA lipoprotein; Region: Lipoprotein_9; cl17547 665029001444 cytoplasmic membrane lipoprotein-28; Provisional; Region: PRK09861 665029001445 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 665029001446 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 665029001447 non-specific DNA binding site [nucleotide binding]; other site 665029001448 salt bridge; other site 665029001449 sequence-specific DNA binding site [nucleotide binding]; other site 665029001450 Winged helix-turn-helix DNA-binding; Region: HTH_35; pfam13693 665029001451 beta-lactam binding protein AmpH; Provisional; Region: PRK10662 665029001452 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 665029001453 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 665029001454 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 665029001455 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 665029001456 active site 665029001457 SUMO-1 interface [polypeptide binding]; other site 665029001458 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 665029001459 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 665029001460 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 665029001461 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 665029001462 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 665029001463 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 665029001464 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 665029001465 DNA binding residues [nucleotide binding] 665029001466 DNA primase; Validated; Region: dnaG; PRK05667 665029001467 CHC2 zinc finger; Region: zf-CHC2; pfam01807 665029001468 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 665029001469 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 665029001470 active site 665029001471 metal binding site [ion binding]; metal-binding site 665029001472 interdomain interaction site; other site 665029001473 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 665029001474 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278 665029001475 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 665029001476 UGMP family protein; Validated; Region: PRK09604 665029001477 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 665029001478 Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf...; Region: RNase_T2; cl00208 665029001479 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 665029001480 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 665029001481 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 665029001482 Poly A polymerase head domain; Region: PolyA_pol; pfam01743 665029001483 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 665029001484 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 665029001485 Zn2+ binding site [ion binding]; other site 665029001486 Mg2+ binding site [ion binding]; other site 665029001487 SH3 domain-containing protein; Provisional; Region: PRK10884 665029001488 Bacterial SH3 domain homologues; Region: SH3b; smart00287 665029001489 Uncharacterized conserved protein [Function unknown]; Region: COG3025 665029001490 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 665029001491 putative active site [active] 665029001492 putative metal binding residues [ion binding]; other site 665029001493 signature motif; other site 665029001494 putative triphosphate binding site [ion binding]; other site 665029001495 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 665029001496 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 665029001497 metal binding triad; other site 665029001498 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 665029001499 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 665029001500 metal binding triad; other site 665029001501 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 665029001502 bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316 665029001503 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 665029001504 putative ribose interaction site [chemical binding]; other site 665029001505 putative ADP binding site [chemical binding]; other site 665029001506 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 665029001507 active site 665029001508 nucleotide binding site [chemical binding]; other site 665029001509 HIGH motif; other site 665029001510 KMSKS motif; other site 665029001511 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2960 665029001512 3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353 665029001513 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 665029001514 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 665029001515 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 665029001516 putative active site [active] 665029001517 metal binding site [ion binding]; metal-binding site 665029001518 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 665029001519 hypothetical protein; Provisional; Region: PRK11653 665029001520 outer membrane channel protein; Reviewed; Region: tolC; PRK09465 665029001521 ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729 665029001522 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 665029001523 dimer interface [polypeptide binding]; other site 665029001524 ADP-ribose binding site [chemical binding]; other site 665029001525 active site 665029001526 nudix motif; other site 665029001527 metal binding site [ion binding]; metal-binding site 665029001528 putative dehydrogenase; Provisional; Region: PRK11039 665029001529 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 665029001530 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 665029001531 active site 665029001532 metal binding site [ion binding]; metal-binding site 665029001533 hexamer interface [polypeptide binding]; other site 665029001534 esterase YqiA; Provisional; Region: PRK11071 665029001535 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 665029001536 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 665029001537 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 665029001538 ATP binding site [chemical binding]; other site 665029001539 Mg2+ binding site [ion binding]; other site 665029001540 G-X-G motif; other site 665029001541 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 665029001542 anchoring element; other site 665029001543 dimer interface [polypeptide binding]; other site 665029001544 ATP binding site [chemical binding]; other site 665029001545 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 665029001546 active site 665029001547 metal binding site [ion binding]; metal-binding site 665029001548 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 665029001549 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 665029001550 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 665029001551 Protein of unknown function (DUF1062); Region: DUF1062; pfam06353 665029001552 Creatinine amidohydrolase; Region: Creatininase; pfam02633 665029001553 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 665029001554 Dihydroorotate dehydrogenase (DHOD) and Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the...; Region: DHOD_DHPD_FMN; cd02810 665029001555 active site 665029001556 FMN binding site [chemical binding]; other site 665029001557 substrate binding site [chemical binding]; other site 665029001558 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; cl17818 665029001559 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 665029001560 Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001 665029001561 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 665029001562 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 665029001563 catalytic residue [active] 665029001564 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 665029001565 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 665029001566 active site 665029001567 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 665029001568 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 665029001569 active site 665029001570 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 665029001571 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 665029001572 NAD(P) binding site [chemical binding]; other site 665029001573 active site 665029001574 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 665029001575 Condensation domain; Region: Condensation; pfam00668 665029001576 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 665029001577 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 665029001578 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 665029001579 acyl-activating enzyme (AAE) consensus motif; other site 665029001580 AMP binding site [chemical binding]; other site 665029001581 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 665029001582 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 665029001583 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 665029001584 active site 665029001585 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 665029001586 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 665029001587 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 665029001588 KR domain; Region: KR; pfam08659 665029001589 putative NADP binding site [chemical binding]; other site 665029001590 active site 665029001591 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 665029001592 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 665029001593 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 665029001594 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 665029001595 active site 665029001596 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 665029001597 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 665029001598 KR domain; Region: KR; pfam08659 665029001599 NAD(P) binding site [chemical binding]; other site 665029001600 active site 665029001601 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 665029001602 peptide synthase; Validated; Region: PRK05691 665029001603 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 665029001604 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 665029001605 putative substrate translocation pore; other site 665029001606 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 665029001607 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 665029001608 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 665029001609 substrate binding pocket [chemical binding]; other site 665029001610 membrane-bound complex binding site; other site 665029001611 hinge residues; other site 665029001612 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 665029001613 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 665029001614 CAP-like domain; other site 665029001615 active site 665029001616 primary dimer interface [polypeptide binding]; other site 665029001617 1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional; Region: PRK15018 665029001618 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 665029001619 putative acyl-acceptor binding pocket; other site 665029001620 FtsI repressor; Provisional; Region: PRK10883 665029001621 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 665029001622 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 665029001623 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 665029001624 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 665029001625 active site 665029001626 catalytic tetrad [active] 665029001627 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 665029001628 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 665029001629 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 665029001630 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 665029001631 diaminobutyrate--2-oxoglutarate aminotransferase; Provisional; Region: PRK06931 665029001632 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 665029001633 inhibitor-cofactor binding pocket; inhibition site 665029001634 pyridoxal 5'-phosphate binding site [chemical binding]; other site 665029001635 catalytic residue [active] 665029001636 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 665029001637 pyridoxal 5'-phosphate binding site [chemical binding]; other site 665029001638 catalytic residue [active] 665029001639 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 665029001640 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 665029001641 cystathionine beta-lyase; Provisional; Region: PRK08114 665029001642 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 665029001643 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 665029001644 catalytic residue [active] 665029001645 biopolymer transport protein ExbB; Provisional; Region: PRK10414 665029001646 biopolymer transport protein ExbD; Provisional; Region: PRK11267 665029001647 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 665029001648 citrate-proton symporter; Provisional; Region: PRK15075 665029001649 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 665029001650 putative substrate translocation pore; other site 665029001651 oxidoreductase; Provisional; Region: PRK07985 665029001652 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 665029001653 NAD(P) binding site [chemical binding]; other site 665029001654 active site 665029001655 Spore Coat Protein U domain; Region: SCPU; pfam05229 665029001656 Spore Coat Protein U domain; Region: SCPU; pfam05229 665029001657 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 665029001658 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 665029001659 PapC C-terminal domain; Region: PapC_C; pfam13953 665029001660 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 665029001661 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 665029001662 Spore Coat Protein U domain; Region: SCPU; pfam05229 665029001663 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 665029001664 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 665029001665 DNA-binding site [nucleotide binding]; DNA binding site 665029001666 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 665029001667 pyridoxal 5'-phosphate binding site [chemical binding]; other site 665029001668 homodimer interface [polypeptide binding]; other site 665029001669 catalytic residue [active] 665029001670 sigma70 family sigma factor YlaC; Region: YlaC; pfam10777 665029001671 Uncharacterized protein conserved in bacteria, putative lipoprotein [Function unknown]; Region: LprI; COG4461 665029001672 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 665029001673 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 665029001674 DNA binding site [nucleotide binding] 665029001675 PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397 665029001676 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 665029001677 active site 665029001678 ferrichrome/ferrioxamine B periplasmic transporter; Provisional; Region: PRK14048 665029001679 Periplasmic binding protein TroA_f. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_f; cd01139 665029001680 putative ligand binding residues [chemical binding]; other site 665029001681 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 665029001682 Ferritin-like domain; Region: Ferritin; pfam00210 665029001683 ferroxidase diiron center [ion binding]; other site 665029001684 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 665029001685 H-loop/switch region; other site 665029001686 Phytochelatin synthase; Region: Phytochelatin; pfam05023 665029001687 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 665029001688 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 665029001689 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 665029001690 beta-galactosidase; Region: BGL; TIGR03356 665029001691 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 665029001692 beta-galactosidase; Region: BGL; TIGR03356 665029001693 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 665029001694 methionine cluster; other site 665029001695 active site 665029001696 phosphorylation site [posttranslational modification] 665029001697 metal binding site [ion binding]; metal-binding site 665029001698 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 665029001699 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 665029001700 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 665029001701 active site 665029001702 P-loop; other site 665029001703 phosphorylation site [posttranslational modification] 665029001704 Transcriptional regulators [Transcription]; Region: PurR; COG1609 665029001705 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 665029001706 DNA binding site [nucleotide binding] 665029001707 domain linker motif; other site 665029001708 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 665029001709 dimerization interface (closed form) [polypeptide binding]; other site 665029001710 ligand binding site [chemical binding]; other site 665029001711 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 665029001712 Na binding site [ion binding]; other site 665029001713 PAS fold; Region: PAS_4; pfam08448 665029001714 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 665029001715 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 665029001716 DNA binding residues [nucleotide binding] 665029001717 dimerization interface [polypeptide binding]; other site 665029001718 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 665029001719 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 665029001720 dimerization interface [polypeptide binding]; other site 665029001721 putative Zn2+ binding site [ion binding]; other site 665029001722 putative DNA binding site [nucleotide binding]; other site 665029001723 AsnC family; Region: AsnC_trans_reg; pfam01037 665029001724 aromatic amino acid exporter; Provisional; Region: PRK11689 665029001725 multidrug efflux system protein MdtI; Provisional; Region: PRK10650 665029001726 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 665029001727 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 665029001728 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 665029001729 GAF domain; Region: GAF; pfam01590 665029001730 Histidine kinase; Region: His_kinase; pfam06580 665029001731 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 665029001732 ATP binding site [chemical binding]; other site 665029001733 Mg2+ binding site [ion binding]; other site 665029001734 G-X-G motif; other site 665029001735 putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697 665029001736 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 665029001737 active site 665029001738 phosphorylation site [posttranslational modification] 665029001739 intermolecular recognition site; other site 665029001740 dimerization interface [polypeptide binding]; other site 665029001741 LytTr DNA-binding domain; Region: LytTR; pfam04397 665029001742 Protein of unknown function (DUF466); Region: DUF466; pfam04328 665029001743 carbon starvation protein A; Provisional; Region: PRK15015 665029001744 Carbon starvation protein CstA; Region: CstA; pfam02554 665029001745 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 665029001746 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 665029001747 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 665029001748 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 665029001749 dimerization interface [polypeptide binding]; other site 665029001750 beta-lactamase/D-alanine carboxypeptidase; Provisional; Region: ampC; PRK11289 665029001751 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 665029001752 C-lysozyme inhibitor; Provisional; Region: PRK09993 665029001753 VirK protein; Region: VirK; pfam06903 665029001754 Amidinotransferase; Region: Amidinotransf; cl12043 665029001755 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 665029001756 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 665029001757 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 665029001758 active site 665029001759 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 665029001760 Coenzyme A binding pocket [chemical binding]; other site 665029001761 type III secretion protein, YscU/HrpY family; Region: FlhB_rel_III; TIGR01404 665029001762 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 665029001763 Bacterial export proteins, family 1; Region: Bac_export_1; pfam01311 665029001764 type III secretion protein, HrpO family; Region: fliQ_rel_III; TIGR01403 665029001765 type III secretion apparatus protein, YscR/HrcR family; Region: yscR; TIGR01102 665029001766 type III secretion system apparatus protein YscQ/HrcQ; Region: SpaO_YscQ; TIGR02551 665029001767 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 665029001768 type III secretion apparatus H+-transporting two-sector ATPase; Region: III_secr_ATP; TIGR02546 665029001769 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 665029001770 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 665029001771 Walker A motif; other site 665029001772 ATP binding site [chemical binding]; other site 665029001773 Walker B motif; other site 665029001774 FHA domain; Region: FHA; pfam00498 665029001775 type III secretion apparatus protein, YscD/HrpQ family; Region: type_III_yscD; TIGR02500 665029001776 type III secretion protein, HrcV family; Region: hrcV; TIGR01399 665029001777 FHIPEP family; Region: FHIPEP; pfam00771 665029001778 HrpJ-like domain; Region: HrpJ; pfam07201 665029001779 TyeA; Region: TyeA; cl07611 665029001780 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 665029001781 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 665029001782 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 665029001783 DNA binding residues [nucleotide binding] 665029001784 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 665029001785 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 665029001786 putative active site [active] 665029001787 heme pocket [chemical binding]; other site 665029001788 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 665029001789 putative active site [active] 665029001790 heme pocket [chemical binding]; other site 665029001791 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 665029001792 Histidine kinase; Region: HisKA_3; pfam07730 665029001793 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 665029001794 ATP binding site [chemical binding]; other site 665029001795 Mg2+ binding site [ion binding]; other site 665029001796 G-X-G motif; other site 665029001797 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 665029001798 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 665029001799 active site 665029001800 phosphorylation site [posttranslational modification] 665029001801 intermolecular recognition site; other site 665029001802 dimerization interface [polypeptide binding]; other site 665029001803 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 665029001804 DNA binding residues [nucleotide binding] 665029001805 dimerization interface [polypeptide binding]; other site 665029001806 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 665029001807 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 665029001808 Walker A motif; other site 665029001809 ATP binding site [chemical binding]; other site 665029001810 Walker B motif; other site 665029001811 arginine finger; other site 665029001812 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 665029001813 Protein of unknown function DUF45; Region: DUF45; cl00636 665029001814 Type III secretion needle MxiH like; Region: MxiH; pfam09392 665029001815 type III secretion apparatus lipoprotein, YscJ/HrcJ family; Region: III_secr_YscJ; TIGR02544 665029001816 HrpE/YscL/FliH and V-type ATPase subunit E; Region: HrpE; pfam06188 665029001817 HrpF protein; Region: HrpF; pfam06266 665029001818 type III secretion outer membrane pore, YscC/HrcC family; Region: type_III_yscC; TIGR02516 665029001819 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 665029001820 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 665029001821 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 665029001822 HrpZ; Region: Hairpins; pfam04877 665029001823 Tir chaperone protein (CesT) family; Region: CesT; pfam05932 665029001824 YopJ Serine/Threonine acetyltransferase; Region: YopJ; cl07849 665029001825 Pectate lyase; Region: Pectate_lyase; pfam03211 665029001826 Pathogenicity factor; Region: AvrE; pfam11725 665029001827 Tir chaperone protein (CesT) family; Region: CesT; pfam05932 665029001828 Transcriptional regulator [Transcription]; Region: LysR; COG0583 665029001829 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 665029001830 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 665029001831 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 665029001832 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733 665029001833 Protein of unknown function (DUF3828); Region: DUF3828; pfam12883 665029001834 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 665029001835 catalytic residue [active] 665029001836 PAAR motif; Region: PAAR_motif; pfam05488 665029001837 GIY-YIG catalytic domain; Region: GIY-YIG; pfam01541 665029001838 GIY-YIG motif/motif A; other site 665029001839 active site 665029001840 catalytic site [active] 665029001841 Protein of unknown function (DUF1525); Region: DUF1525; pfam07511 665029001842 integrating conjugative element protein, PFL_4710 family; Region: conj_TIGR03756 665029001843 integrating conjugative element protein, PFL_4711 family; Region: conj_TIGR03755 665029001844 integrating conjugative element relaxase, PFL_4751 family; Region: ICE_TraI_Pfluor; TIGR03760 665029001845 Protein of unknown function (DUF1528); Region: DUF1528; pfam07515 665029001846 potential frameshift: common BLAST hit: gi|153949143|ref|YP_001402640.1| phage integrase 665029001847 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 665029001848 active site 665029001849 catalytic residues [active] 665029001850 DNA binding site [nucleotide binding] 665029001851 Int/Topo IB signature motif; other site 665029001852 ornithine decarboxylase; Provisional; Region: PRK13578 665029001853 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 665029001854 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 665029001855 homodimer interface [polypeptide binding]; other site 665029001856 pyridoxal 5'-phosphate binding site [chemical binding]; other site 665029001857 catalytic residue [active] 665029001858 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 665029001859 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 665029001860 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 665029001861 murein transglycosylase C; Provisional; Region: mltC; PRK11671 665029001862 Domain of unknown function (DUF3393); Region: DUF3393; pfam11873 665029001863 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 665029001864 N-acetyl-D-glucosamine binding site [chemical binding]; other site 665029001865 catalytic residue [active] 665029001866 oxidative damage protection protein; Provisional; Region: PRK05408 665029001867 adenine DNA glycosylase; Provisional; Region: PRK10880 665029001868 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 665029001869 minor groove reading motif; other site 665029001870 helix-hairpin-helix signature motif; other site 665029001871 substrate binding pocket [chemical binding]; other site 665029001872 active site 665029001873 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 665029001874 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 665029001875 DNA binding and oxoG recognition site [nucleotide binding] 665029001876 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 665029001877 hypothetical protein; Provisional; Region: PRK11702 665029001878 hypothetical protein; Provisional; Region: PRK10626 665029001879 Protein of unknown function (DUF2884); Region: DUF2884; pfam11101 665029001880 HemN family oxidoreductase; Provisional; Region: PRK05660 665029001881 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 665029001882 FeS/SAM binding site; other site 665029001883 HemN C-terminal domain; Region: HemN_C; pfam06969 665029001884 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 665029001885 active site 665029001886 dimerization interface [polypeptide binding]; other site 665029001887 YGGT family; Region: YGGT; pfam02325 665029001888 YGGT family; Region: YGGT; pfam02325 665029001889 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 665029001890 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 665029001891 catalytic residue [active] 665029001892 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 665029001893 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 665029001894 Walker A motif; other site 665029001895 ATP binding site [chemical binding]; other site 665029001896 Walker B motif; other site 665029001897 RNA polymerase sigma factor; Provisional; Region: PRK12512 665029001898 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 665029001899 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 665029001900 DNA binding residues [nucleotide binding] 665029001901 Thiol:disulfide interchange protein [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4232 665029001902 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 665029001903 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 665029001904 DsbD alpha interface [polypeptide binding]; other site 665029001905 catalytic residues [active] 665029001906 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 665029001907 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 665029001908 catalytic triad [active] 665029001909 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 665029001910 hypothetical protein; Validated; Region: PRK00228 665029001911 glutathione synthetase; Provisional; Region: PRK05246 665029001912 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 665029001913 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 665029001914 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 665029001915 RNA methyltransferase, RsmE family; Region: TIGR00046 665029001916 DNA-specific endonuclease I; Provisional; Region: PRK15137 665029001917 Endonuclease I [DNA replication, recombination, and repair]; Region: EndA; COG2356 665029001918 hypothetical protein; Provisional; Region: PRK04860 665029001919 Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091 665029001920 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 665029001921 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 665029001922 putative substrate translocation pore; other site 665029001923 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 665029001924 S-adenosylmethionine synthetase; Validated; Region: PRK05250 665029001925 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 665029001926 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 665029001927 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 665029001928 arginine decarboxylase; Provisional; Region: PRK05354 665029001929 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 665029001930 dimer interface [polypeptide binding]; other site 665029001931 active site 665029001932 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 665029001933 catalytic residues [active] 665029001934 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 665029001935 Bacterial protein of unknown function (DUF937); Region: DUF937; cl01528 665029001936 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 665029001937 agmatinase; Region: agmatinase; TIGR01230 665029001938 oligomer interface [polypeptide binding]; other site 665029001939 putative active site [active] 665029001940 Mn binding site [ion binding]; other site 665029001941 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 665029001942 putative active site [active] 665029001943 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 665029001944 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 665029001945 dimer interface [polypeptide binding]; other site 665029001946 ligand binding site [chemical binding]; other site 665029001947 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 665029001948 dimerization interface [polypeptide binding]; other site 665029001949 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 665029001950 dimer interface [polypeptide binding]; other site 665029001951 putative CheW interface [polypeptide binding]; other site 665029001952 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 665029001953 transketolase; Reviewed; Region: PRK12753 665029001954 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 665029001955 TPP-binding site [chemical binding]; other site 665029001956 dimer interface [polypeptide binding]; other site 665029001957 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 665029001958 PYR/PP interface [polypeptide binding]; other site 665029001959 dimer interface [polypeptide binding]; other site 665029001960 TPP binding site [chemical binding]; other site 665029001961 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 665029001962 erythrose 4-phosphate dehydrogenase; Provisional; Region: PRK13535 665029001963 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 665029001964 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 665029001965 phosphoglycerate kinase; Provisional; Region: pgk; PRK00073 665029001966 Phosphoglycerate kinase; Region: PGK; pfam00162 665029001967 substrate binding site [chemical binding]; other site 665029001968 hinge regions; other site 665029001969 ADP binding site [chemical binding]; other site 665029001970 catalytic site [active] 665029001971 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 665029001972 Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946 665029001973 active site 665029001974 intersubunit interface [polypeptide binding]; other site 665029001975 zinc binding site [ion binding]; other site 665029001976 Na+ binding site [ion binding]; other site 665029001977 mechanosensitive channel MscS; Provisional; Region: PRK10334 665029001978 Mechanosensitive ion channel; Region: MS_channel; pfam00924 665029001979 LysE type translocator; Region: LysE; cl00565 665029001980 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 665029001981 putative trimer interface [polypeptide binding]; other site 665029001982 putative CoA binding site [chemical binding]; other site 665029001983 Flavin-binding monooxygenase-like; Region: FMO-like; pfam00743 665029001984 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 665029001985 Uncharacterized conserved protein [Function unknown]; Region: COG4095 665029001986 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 665029001987 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 665029001988 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 665029001989 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 665029001990 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 665029001991 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 665029001992 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 665029001993 inhibitor-cofactor binding pocket; inhibition site 665029001994 pyridoxal 5'-phosphate binding site [chemical binding]; other site 665029001995 catalytic residue [active] 665029001996 LysE type translocator; Region: LysE; cl00565 665029001997 Uncharacterized conserved protein [Function unknown]; Region: COG2968 665029001998 oxidative stress defense protein; Provisional; Region: PRK11087 665029001999 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 665029002000 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 665029002001 The C-terminal substrate binding domain of LysR-type transcriptional regulator, ArgP (IciA), for arginine exporter (ArgO); contains the type 2 periplasmic binding fold; Region: PBP2_IciA_ArgP; cd08428 665029002002 putative dimerization interface [polypeptide binding]; other site 665029002003 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 665029002004 tetramer (dimer of dimers) interface [polypeptide binding]; other site 665029002005 active site 665029002006 dimer interface [polypeptide binding]; other site 665029002007 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 665029002008 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 665029002009 ligand binding site [chemical binding]; other site 665029002010 NAD binding site [chemical binding]; other site 665029002011 tetramer interface [polypeptide binding]; other site 665029002012 catalytic site [active] 665029002013 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 665029002014 L-serine binding site [chemical binding]; other site 665029002015 ACT domain interface; other site 665029002016 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360 665029002017 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 665029002018 Z-ring-associated protein; Provisional; Region: PRK10972 665029002019 hypothetical protein; Reviewed; Region: PRK01736 665029002020 proline aminopeptidase P II; Provisional; Region: PRK10879 665029002021 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 665029002022 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 665029002023 active site 665029002024 2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK05732 665029002025 2-polyprenyl-6-methoxyphenol 4-hydroxylase; Region: UbiH; TIGR01984 665029002026 oxidoreductase; Provisional; Region: PRK08013 665029002027 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 665029002028 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 665029002029 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 665029002030 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 665029002031 lipoyl attachment site [posttranslational modification]; other site 665029002032 glycine dehydrogenase; Provisional; Region: PRK05367 665029002033 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 665029002034 tetramer interface [polypeptide binding]; other site 665029002035 pyridoxal 5'-phosphate binding site [chemical binding]; other site 665029002036 catalytic residue [active] 665029002037 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 665029002038 tetramer interface [polypeptide binding]; other site 665029002039 pyridoxal 5'-phosphate binding site [chemical binding]; other site 665029002040 catalytic residue [active] 665029002041 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase; Provisional; Region: benD; PRK12823 665029002042 classical (c) SDRs; Region: SDR_c; cd05233 665029002043 NAD(P) binding site [chemical binding]; other site 665029002044 active site 665029002045 HD domain; Region: HD_3; pfam13023 665029002046 hemolysin; Provisional; Region: PRK15087 665029002047 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 665029002048 putative global regulator; Reviewed; Region: PRK09559 665029002049 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 665029002050 hypothetical protein; Provisional; Region: PRK10878 665029002051 Protein of unknown function (DUF1434); Region: DUF1434; pfam07254 665029002052 flavodoxin FldB; Provisional; Region: PRK12359 665029002053 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 665029002054 EamA-like transporter family; Region: EamA; pfam00892 665029002055 Pectate lyase; Region: Pec_lyase_C; cl01593 665029002056 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 665029002057 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 665029002058 active site 665029002059 Int/Topo IB signature motif; other site 665029002060 protein disulfide isomerase II DsbC; Provisional; Region: PRK10877 665029002061 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 665029002062 dimerization domain [polypeptide binding]; other site 665029002063 dimer interface [polypeptide binding]; other site 665029002064 catalytic residues [active] 665029002065 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 665029002066 DHH family; Region: DHH; pfam01368 665029002067 DHHA1 domain; Region: DHHA1; pfam02272 665029002068 peptide chain release factor 2; Validated; Region: prfB; PRK00578 665029002069 This domain is found in peptide chain release factors; Region: PCRF; smart00937 665029002070 RF-1 domain; Region: RF-1; pfam00472 665029002071 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 665029002072 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 665029002073 dimer interface [polypeptide binding]; other site 665029002074 putative anticodon binding site; other site 665029002075 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 665029002076 motif 1; other site 665029002077 active site 665029002078 motif 2; other site 665029002079 motif 3; other site 665029002080 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 665029002081 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 665029002082 Major Facilitator Superfamily; Region: MFS_1; pfam07690 665029002083 putative substrate translocation pore; other site 665029002084 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 665029002085 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 665029002086 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 665029002087 dimerization interface [polypeptide binding]; other site 665029002088 diaminopimelate decarboxylase; Provisional; Region: PRK11165 665029002089 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 665029002090 active site 665029002091 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 665029002092 substrate binding site [chemical binding]; other site 665029002093 catalytic residues [active] 665029002094 dimer interface [polypeptide binding]; other site 665029002095 DNA-binding transcriptional regulator GalR; Provisional; Region: PRK10727 665029002096 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 665029002097 DNA binding site [nucleotide binding] 665029002098 domain linker motif; other site 665029002099 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 665029002100 dimerization interface (closed form) [polypeptide binding]; other site 665029002101 ligand binding site [chemical binding]; other site 665029002102 potential frameshift: common BLAST hit: gi|259909544|ref|YP_002649900.1| molybdopterin oxidoreductase 665029002103 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 665029002104 molybdopterin cofactor binding site; other site 665029002105 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 665029002106 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 665029002107 molybdopterin cofactor binding site; other site 665029002108 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 665029002109 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 665029002110 Toxin SymE, type I toxin-antitoxin system; Region: SymE_toxin; pfam08845 665029002111 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 665029002112 Pre-toxin domain with VENN motif; Region: PT-VENN; pfam04829 665029002113 Cytotoxic; Region: Cytotoxic; pfam09000 665029002114 Toxin SymE, type I toxin-antitoxin system; Region: SymE_toxin; pfam08845 665029002115 A pre-toxin domain with the TG motif; Region: PT-TG; pfam14449 665029002116 Domain of unknown function (DUF4258); Region: DUF4258; pfam14076 665029002117 potential frameshift: common BLAST hit: gi|259909516|ref|YP_002649872.1| adhesin/hemagglutinin/hemolysin 665029002118 Pre-toxin domain with VENN motif; Region: PT-VENN; pfam04829 665029002119 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 665029002120 Toxin SymE, type I toxin-antitoxin system; Region: SymE_toxin; pfam08845 665029002121 haemagglutination activity domain; Region: Haemagg_act; pfam05860 665029002122 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 665029002123 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 665029002124 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 665029002125 Pre-toxin domain with VENN motif; Region: PT-VENN; pfam04829 665029002126 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 665029002127 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 665029002128 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 665029002129 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 665029002130 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 665029002131 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 665029002132 multidrug efflux system subunit MdtA; Provisional; Region: PRK11556 665029002133 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 665029002134 HlyD family secretion protein; Region: HlyD_3; pfam13437 665029002135 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 665029002136 Protein export membrane protein; Region: SecD_SecF; cl14618 665029002137 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 665029002138 potential frameshift: common BLAST hit: gi|188534891|ref|YP_001908688.1| RND efflux system, outer membrane lipoprotein 665029002139 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 665029002140 potential protein location (hypothetical protein predicted by Glimmer/Critica) that overlaps protein (hypothetical protein predicted by Glimmer/Critica) 665029002141 potential protein location (hypothetical protein predicted by Glimmer/Critica) that overlaps protein (hypothetical protein predicted by Glimmer/Critica) 665029002142 bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase; Validated; Region: PRK08043 665029002143 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 665029002144 putative acyl-acceptor binding pocket; other site 665029002145 C-terminal domain of the acyl-acyl carrier protein synthetase (also called 2-acylglycerophosphoethanolamine acyltransferase, Aas); Region: AAS_C; cd05909 665029002146 acyl-activating enzyme (AAE) consensus motif; other site 665029002147 putative AMP binding site [chemical binding]; other site 665029002148 lysophospholipid transporter LplT; Provisional; Region: PRK11195 665029002149 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 665029002150 putative substrate translocation pore; other site 665029002151 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 665029002152 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 665029002153 active site 665029002154 catalytic tetrad [active] 665029002155 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 665029002156 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 665029002157 MutH is a 28kD endonuclease involved in methyl-directed DNA mismatch repair in gram negative bacteria. MutH is both sequence-specific and methylation-specific, introducing a nick in the unmethylated strand of a hemi-methylated d(GATC) DNA duplex. MutH...; Region: MutH_Sau3AI; cd00583 665029002158 putative DNA-binding cleft [nucleotide binding]; other site 665029002159 putative DNA clevage site; other site 665029002160 molecular lever; other site 665029002161 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 665029002162 putative active site [active] 665029002163 Ap4A binding site [chemical binding]; other site 665029002164 nudix motif; other site 665029002165 putative metal binding site [ion binding]; other site 665029002166 fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain; Provisional; Region: PRK11061 665029002167 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 665029002168 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 665029002169 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 665029002170 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 665029002171 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 665029002172 thymidylate synthase; Reviewed; Region: thyA; PRK01827 665029002173 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 665029002174 dimerization interface [polypeptide binding]; other site 665029002175 active site 665029002176 D-alanyl-D-alanine dipeptidase; Provisional; Region: PRK10178 665029002177 hypothetical protein; Provisional; Region: PRK10506 665029002178 Prokaryotic N-terminal methylation motif; Region: N_methyl; pfam07963 665029002179 hypothetical protein; Provisional; Region: PRK10557 665029002180 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 665029002181 Protein of unknown function (DUF2509); Region: DUF2509; cl11672 665029002182 hypothetical protein; Provisional; Region: PRK10332 665029002183 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 665029002184 Prepilin peptidase dependent protein C term (DUF3728); Region: DUF3728; pfam12528 665029002185 Exonuclease V gamma subunit [DNA replication, recombination, and repair]; Region: RecC; COG1330 665029002186 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 665029002187 protease3; Provisional; Region: PRK15101 665029002188 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 665029002189 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 665029002190 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 665029002191 exonuclease V subunit beta; Provisional; Region: recB; PRK10876 665029002192 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 665029002193 exonuclease V subunit alpha; Provisional; Region: recD; PRK10875 665029002194 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 665029002195 ATP binding site [chemical binding]; other site 665029002196 putative Mg++ binding site [ion binding]; other site 665029002197 Family description; Region: UvrD_C_2; pfam13538 665029002198 Protein of unknown function (DUF1440); Region: DUF1440; cl01380 665029002199 N-acetylglutamate synthase; Validated; Region: PRK05279 665029002200 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 665029002201 putative feedback inhibition sensing region; other site 665029002202 putative nucleotide binding site [chemical binding]; other site 665029002203 putative substrate binding site [chemical binding]; other site 665029002204 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 665029002205 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 665029002206 Coenzyme A binding pocket [chemical binding]; other site 665029002207 AMIN domain; Region: AMIN; pfam11741 665029002208 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 665029002209 active site 665029002210 metal binding site [ion binding]; metal-binding site 665029002211 murein transglycosylase A; Provisional; Region: mltA; PRK11162 665029002212 MltA specific insert domain; Region: MltA; pfam03562 665029002213 3D domain; Region: 3D; pfam06725 665029002214 sulfur acceptor protein CsdL; Provisional; Region: PRK15116 665029002215 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 665029002216 putative ATP binding site [chemical binding]; other site 665029002217 putative substrate interface [chemical binding]; other site 665029002218 Fe-S metabolism associated domain; Region: SufE; cl00951 665029002219 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 665029002220 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 665029002221 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 665029002222 catalytic residue [active] 665029002223 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 665029002224 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 665029002225 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 665029002226 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 665029002227 dimerization interface [polypeptide binding]; other site 665029002228 substrate binding pocket [chemical binding]; other site 665029002229 hypothetical protein; Provisional; Region: PRK10873 665029002230 putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760 665029002231 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 665029002232 flap endonuclease-like protein; Provisional; Region: PRK09482 665029002233 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 665029002234 active site 665029002235 metal binding site 1 [ion binding]; metal-binding site 665029002236 putative 5' ssDNA interaction site; other site 665029002237 metal binding site 3; metal-binding site 665029002238 metal binding site 2 [ion binding]; metal-binding site 665029002239 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 665029002240 putative DNA binding site [nucleotide binding]; other site 665029002241 putative metal binding site [ion binding]; other site 665029002242 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 665029002243 Domain of unknown function (DUF3412); Region: DUF3412; pfam11892 665029002244 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904 665029002245 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 665029002246 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 665029002247 SecY interacting protein Syd; Provisional; Region: PRK04968 665029002248 tRNA pseudouridine synthase C; Region: DUF446; pfam04287 665029002249 tRNA pseudouridine isomerase C; Region: PseudoU_synth_TruC; cd02563 665029002250 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 665029002251 probable active site [active] 665029002252 flavodoxin; Provisional; Region: PRK08105 665029002253 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 665029002254 hybrid sensory histidine kinase BarA; Provisional; Region: PRK11107 665029002255 Uncharacterized signal transduction histidine kinase domain (DUF2222); Region: DUF2222; pfam09984 665029002256 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 665029002257 dimerization interface [polypeptide binding]; other site 665029002258 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 665029002259 dimer interface [polypeptide binding]; other site 665029002260 phosphorylation site [posttranslational modification] 665029002261 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 665029002262 ATP binding site [chemical binding]; other site 665029002263 Mg2+ binding site [ion binding]; other site 665029002264 G-X-G motif; other site 665029002265 Uncharacterized domain of BarA-like signal transduction histidine kinases [Signal transduction mechanisms]; Region: COG4999 665029002266 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 665029002267 active site 665029002268 phosphorylation site [posttranslational modification] 665029002269 intermolecular recognition site; other site 665029002270 dimerization interface [polypeptide binding]; other site 665029002271 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 665029002272 putative binding surface; other site 665029002273 active site 665029002274 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 665029002275 TRAM domain; Region: TRAM; pfam01938 665029002276 (p)ppGpp synthetase I/GTP pyrophosphokinase; Provisional; Region: relA; PRK10872 665029002277 HD domain; Region: HD_4; pfam13328 665029002278 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 665029002279 synthetase active site [active] 665029002280 NTP binding site [chemical binding]; other site 665029002281 metal binding site [ion binding]; metal-binding site 665029002282 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 665029002283 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 665029002284 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 665029002285 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 665029002286 homodimer interface [polypeptide binding]; other site 665029002287 metal binding site [ion binding]; metal-binding site 665029002288 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 665029002289 homodimer interface [polypeptide binding]; other site 665029002290 active site 665029002291 putative chemical substrate binding site [chemical binding]; other site 665029002292 metal binding site [ion binding]; metal-binding site 665029002293 CTP synthetase; Validated; Region: pyrG; PRK05380 665029002294 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 665029002295 Catalytic site [active] 665029002296 active site 665029002297 UTP binding site [chemical binding]; other site 665029002298 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 665029002299 active site 665029002300 putative oxyanion hole; other site 665029002301 catalytic triad [active] 665029002302 enolase; Provisional; Region: eno; PRK00077 665029002303 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 665029002304 dimer interface [polypeptide binding]; other site 665029002305 metal binding site [ion binding]; metal-binding site 665029002306 substrate binding pocket [chemical binding]; other site 665029002307 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 665029002308 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 665029002309 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 665029002310 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 665029002311 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 665029002312 substrate binding pocket [chemical binding]; other site 665029002313 membrane-bound complex binding site; other site 665029002314 hinge residues; other site 665029002315 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 665029002316 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 665029002317 Walker A/P-loop; other site 665029002318 ATP binding site [chemical binding]; other site 665029002319 Q-loop/lid; other site 665029002320 ABC transporter signature motif; other site 665029002321 Walker B; other site 665029002322 D-loop; other site 665029002323 H-loop/switch region; other site 665029002324 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 665029002325 dimer interface [polypeptide binding]; other site 665029002326 conserved gate region; other site 665029002327 putative PBP binding loops; other site 665029002328 ABC-ATPase subunit interface; other site 665029002329 Yersinia/Haemophilus virulence surface antigen; Region: Peptidase_C58; cl04145 665029002330 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 665029002331 active site 665029002332 sulfite reductase subunit alpha; Provisional; Region: cysJ; PRK10953 665029002333 Flavodoxin; Region: Flavodoxin_1; pfam00258 665029002334 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 665029002335 FAD binding pocket [chemical binding]; other site 665029002336 FAD binding motif [chemical binding]; other site 665029002337 catalytic residues [active] 665029002338 NAD binding pocket [chemical binding]; other site 665029002339 phosphate binding motif [ion binding]; other site 665029002340 beta-alpha-beta structure motif; other site 665029002341 sulfite reductase subunit beta; Provisional; Region: PRK13504 665029002342 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 665029002343 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 665029002344 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 665029002345 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 665029002346 Active Sites [active] 665029002347 YCII-related domain; Region: YCII; cl00999 665029002348 siroheme synthase; Provisional; Region: cysG; PRK10637 665029002349 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 665029002350 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 665029002351 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 665029002352 active site 665029002353 SAM binding site [chemical binding]; other site 665029002354 homodimer interface [polypeptide binding]; other site 665029002355 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 665029002356 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 665029002357 Active Sites [active] 665029002358 sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124 665029002359 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 665029002360 CysD dimerization site [polypeptide binding]; other site 665029002361 G1 box; other site 665029002362 putative GEF interaction site [polypeptide binding]; other site 665029002363 GTP/Mg2+ binding site [chemical binding]; other site 665029002364 Switch I region; other site 665029002365 G2 box; other site 665029002366 G3 box; other site 665029002367 Switch II region; other site 665029002368 G4 box; other site 665029002369 G5 box; other site 665029002370 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 665029002371 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 665029002372 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 665029002373 ligand-binding site [chemical binding]; other site 665029002374 hypothetical protein; Provisional; Region: PRK10726 665029002375 cell division protein FtsB; Reviewed; Region: ftsB; PRK00888 665029002376 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 665029002377 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 665029002378 substrate binding site; other site 665029002379 dimer interface; other site 665029002380 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 665029002381 homotrimer interaction site [polypeptide binding]; other site 665029002382 zinc binding site [ion binding]; other site 665029002383 CDP-binding sites; other site 665029002384 tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984 665029002385 Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575 665029002386 Permutation of conserved domain; other site 665029002387 active site 665029002388 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 665029002389 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 665029002390 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 665029002391 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 665029002392 S-adenosylmethionine binding site [chemical binding]; other site 665029002393 lipoprotein NlpD; Provisional; Region: nlpD; PRK10871 665029002394 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 665029002395 Peptidase family M23; Region: Peptidase_M23; pfam01551 665029002396 RNA polymerase sigma factor RpoS; Validated; Region: PRK05657 665029002397 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 665029002398 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 665029002399 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 665029002400 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 665029002401 DNA binding residues [nucleotide binding] 665029002402 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 665029002403 MutS domain I; Region: MutS_I; pfam01624 665029002404 MutS domain II; Region: MutS_II; pfam05188 665029002405 MutS domain III; Region: MutS_III; pfam05192 665029002406 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 665029002407 Walker A/P-loop; other site 665029002408 ATP binding site [chemical binding]; other site 665029002409 Q-loop/lid; other site 665029002410 ABC transporter signature motif; other site 665029002411 Walker B; other site 665029002412 D-loop; other site 665029002413 H-loop/switch region; other site 665029002414 Domain of unknown function (DUF4102); Region: DUF4102; pfam13356 665029002415 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 665029002416 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 665029002417 N-acetyl-D-glucosamine binding site [chemical binding]; other site 665029002418 catalytic residue [active] 665029002419 Bacterial type III secretion apparatus protein (OrgA_MxiK); Region: OrgA_MxiK; cl09716 665029002420 invasion protein OrgA; Provisional; Region: PRK15323 665029002421 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 665029002422 type III secretion system needle complex protein PrgJ; Provisional; Region: PRK15325 665029002423 Type III secretion needle MxiH like; Region: MxiH; cl09641 665029002424 type III secretion system needle complex protein PrgH; Provisional; Region: PRK15327; cl12363 665029002425 Type III secretion system protein PrgH-EprH (PrgH); Region: PrgH; pfam09480 665029002426 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 665029002427 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 665029002428 type III secretion outer membrane pore, YscC/HrcC family; Region: type_III_yscC; TIGR02516 665029002429 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 665029002430 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 665029002431 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 665029002432 HrpJ-like domain; Region: HrpJ; cl15454 665029002433 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; cl07980 665029002434 type III secretion system protein InvA; Provisional; Region: PRK15337 665029002435 Invasion protein B family; Region: Invas_SpaK; cl04129 665029002436 ATP synthase SpaL; Validated; Region: PRK08149 665029002437 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 665029002438 Walker A motif; other site 665029002439 ATP binding site [chemical binding]; other site 665029002440 Walker B motif; other site 665029002441 type III secretion system protein SpaO; Validated; Region: PRK08158 665029002442 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 665029002443 type III secretion system protein SpaP; Provisional; Region: spaP; PRK12796 665029002444 Bacterial export proteins, family 3; Region: Bac_export_3; cl00867 665029002445 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 665029002446 type III secretion system protein SpaS; Validated; Region: PRK08156 665029002447 type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552 665029002448 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 665029002449 binding surface 665029002450 TPR motif; other site 665029002451 Secretion system effector C (SseC) like family; Region: SseC; pfam04888 665029002452 Invasion plasmid antigen IpaD; Region: IpaD; cl05827 665029002453 Phosphopantetheine attachment site; Region: PP-binding; cl09936 665029002454 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 665029002455 DNA binding site [nucleotide binding] 665029002456 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 665029002457 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 665029002458 catalytic residues [active] 665029002459 hinge region; other site 665029002460 alpha helical domain; other site 665029002461 Domain of unknown function (DUF3315); Region: DUF3315; cl02275 665029002462 Transglycosylase SLT domain; Region: SLT_2; pfam13406 665029002463 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 665029002464 N-acetyl-D-glucosamine binding site [chemical binding]; other site 665029002465 catalytic residue [active] 665029002466 hypothetical protein; Validated; Region: PRK03661 665029002467 recombinase A; Provisional; Region: recA; PRK09354 665029002468 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 665029002469 hexamer interface [polypeptide binding]; other site 665029002470 Walker A motif; other site 665029002471 ATP binding site [chemical binding]; other site 665029002472 Walker B motif; other site 665029002473 recombination regulator RecX; Reviewed; Region: recX; PRK00117 665029002474 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 665029002475 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 665029002476 motif 1; other site 665029002477 active site 665029002478 motif 2; other site 665029002479 motif 3; other site 665029002480 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 665029002481 DHHA1 domain; Region: DHHA1; pfam02272 665029002482 carbon storage regulator; Provisional; Region: PRK01712 665029002483 fructose-1-P/6-phosphogluconate phosphatase; Provisional; Region: PRK10725 665029002484 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 665029002485 motif II; other site 665029002486 Predicted membrane protein [Function unknown]; Region: COG1238 665029002487 glutamate--cysteine ligase; Provisional; Region: PRK02107 665029002488 S-ribosylhomocysteinase; Provisional; Region: PRK02260 665029002489 hypothetical protein; Provisional; Region: PRK11573 665029002490 Domain of unknown function DUF21; Region: DUF21; pfam01595 665029002491 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 665029002492 Transporter associated domain; Region: CorC_HlyC; smart01091 665029002493 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4137 665029002494 signal recognition particle protein; Provisional; Region: PRK10867 665029002495 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 665029002496 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 665029002497 P loop; other site 665029002498 GTP binding site [chemical binding]; other site 665029002499 Signal peptide binding domain; Region: SRP_SPB; pfam02978 665029002500 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 665029002501 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 665029002502 RimM N-terminal domain; Region: RimM; pfam01782 665029002503 PRC-barrel domain; Region: PRC; pfam05239 665029002504 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 665029002505 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 665029002506 PPR repeat family; Region: PPR_2; pfam13041 665029002507 PPR repeat; Region: PPR; cl03252 665029002508 potential frameshift: common BLAST hit: gi|259909403|ref|YP_002649759.1| CTP synthase 665029002509 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 665029002510 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 665029002511 conserved cys residue [active] 665029002512 potential frameshift: common BLAST hit: gi|259909402|ref|YP_002649758.1| acetyltransferase 665029002513 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 665029002514 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 665029002515 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 665029002516 bifunctional chorismate mutase/prephenate dehydrogenase; Provisional; Region: tyrA; PRK11199 665029002517 Chorismate mutase type II; Region: CM_2; cl00693 665029002518 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 665029002519 prephenate dehydrogenase; Validated; Region: PRK08507 665029002520 bifunctional chorismate mutase/prephenate dehydratase; Provisional; Region: pheA; PRK10622 665029002521 chorismate mutase domain of proteobacterial P-protein, clade 1; Region: CM_P_1; TIGR01797 665029002522 Prephenate dehydratase; Region: PDT; pfam00800 665029002523 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 665029002524 putative L-Phe binding site [chemical binding]; other site 665029002525 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 665029002526 30S subunit binding site; other site 665029002527 outer membrane biogenesis protein BamD; Provisional; Region: PRK10866 665029002528 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 665029002529 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 665029002530 RNA binding surface [nucleotide binding]; other site 665029002531 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 665029002532 active site 665029002533 hypothetical protein; Provisional; Region: PRK10723 665029002534 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 665029002535 protein disaggregation chaperone; Provisional; Region: PRK10865 665029002536 Clp amino terminal domain; Region: Clp_N; pfam02861 665029002537 Clp amino terminal domain; Region: Clp_N; pfam02861 665029002538 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 665029002539 Walker A motif; other site 665029002540 ATP binding site [chemical binding]; other site 665029002541 Walker B motif; other site 665029002542 arginine finger; other site 665029002543 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 665029002544 Walker A motif; other site 665029002545 ATP binding site [chemical binding]; other site 665029002546 Walker B motif; other site 665029002547 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 665029002548 hypothetical protein; Provisional; Region: PRK05421 665029002549 putative catalytic site [active] 665029002550 putative phosphate binding site [ion binding]; other site 665029002551 putative metal binding site [ion binding]; other site 665029002552 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 665029002553 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 665029002554 N-acetyl-D-glucosamine binding site [chemical binding]; other site 665029002555 catalytic residue [active] 665029002556 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 665029002557 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 665029002558 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 665029002559 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 665029002560 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 665029002561 Methyltransferase domain; Region: Methyltransf_11; pfam08241 665029002562 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 665029002563 RNA/DNA hybrid binding site [nucleotide binding]; other site 665029002564 active site 665029002565 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 665029002566 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 665029002567 active site 665029002568 catalytic site [active] 665029002569 substrate binding site [chemical binding]; other site 665029002570 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily; solute-binding domain; Region: SLC-NCS1sbd_u1; cd11555 665029002571 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 665029002572 Na binding site [ion binding]; other site 665029002573 putative substrate binding site [chemical binding]; other site 665029002574 Transcriptional regulators [Transcription]; Region: GntR; COG1802 665029002575 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 665029002576 DNA-binding site [nucleotide binding]; DNA binding site 665029002577 FCD domain; Region: FCD; pfam07729 665029002578 Hydantoin racemase [Amino acid transport and metabolism]; Region: COG4126 665029002579 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 665029002580 Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977 665029002581 active site 665029002582 catalytic site [active] 665029002583 tetramer interface [polypeptide binding]; other site 665029002584 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 665029002585 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 665029002586 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 665029002587 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 665029002588 DNA methylase; Region: N6_N4_Mtase; pfam01555 665029002589 DNA methylase; Region: N6_N4_Mtase; pfam01555 665029002590 Uncharacterized conserved protein [Function unknown]; Region: COG4127 665029002591 Restriction endonuclease; Region: Mrr_cat; pfam04471 665029002592 Protein of unknown function (DUF3225); Region: DUF3225; pfam11533 665029002593 amidase; Provisional; Region: PRK09201 665029002594 Amidase; Region: Amidase; cl11426 665029002595 Protein of unknown function (DUF4089); Region: DUF4089; pfam13318 665029002596 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 665029002597 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 665029002598 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 665029002599 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 665029002600 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 665029002601 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 665029002602 substrate binding pocket [chemical binding]; other site 665029002603 membrane-bound complex binding site; other site 665029002604 hinge residues; other site 665029002605 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 665029002606 dimer interface [polypeptide binding]; other site 665029002607 conserved gate region; other site 665029002608 putative PBP binding loops; other site 665029002609 ABC-ATPase subunit interface; other site 665029002610 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 665029002611 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 665029002612 dimer interface [polypeptide binding]; other site 665029002613 conserved gate region; other site 665029002614 putative PBP binding loops; other site 665029002615 ABC-ATPase subunit interface; other site 665029002616 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 665029002617 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 665029002618 Walker A/P-loop; other site 665029002619 ATP binding site [chemical binding]; other site 665029002620 Q-loop/lid; other site 665029002621 ABC transporter signature motif; other site 665029002622 Walker B; other site 665029002623 D-loop; other site 665029002624 H-loop/switch region; other site 665029002625 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 665029002626 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 665029002627 catalytic residue [active] 665029002628 allantoate amidohydrolase; Reviewed; Region: PRK09290 665029002629 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 665029002630 active site 665029002631 metal binding site [ion binding]; metal-binding site 665029002632 dimer interface [polypeptide binding]; other site 665029002633 OHCU decarboxylase; Region: UraD_2; TIGR03180 665029002634 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 665029002635 active site 665029002636 homotetramer interface [polypeptide binding]; other site 665029002637 xanthine permease; Region: pbuX; TIGR03173 665029002638 C-N hydrolase family amidase; Provisional; Region: PRK10438 665029002639 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 665029002640 active site 665029002641 catalytic triad [active] 665029002642 dimer interface [polypeptide binding]; other site 665029002643 methionine aminotransferase; Validated; Region: PRK09082 665029002644 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 665029002645 pyridoxal 5'-phosphate binding site [chemical binding]; other site 665029002646 homodimer interface [polypeptide binding]; other site 665029002647 catalytic residue [active] 665029002648 Toxin YafO, type II toxin-antitoxin system; Region: YafO_toxin; cl08066 665029002649 methylthioribulose-1-phosphate dehydratase; Provisional; Region: PRK09220 665029002650 intersubunit interface [polypeptide binding]; other site 665029002651 active site 665029002652 Zn2+ binding site [ion binding]; other site 665029002653 2,3-diketo-5-methylthio-1-phosphopentane phosphatase; Region: enolase-ppase; TIGR01691 665029002654 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 665029002655 motif II; other site 665029002656 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791 665029002657 Cupin domain; Region: Cupin_2; cl17218 665029002658 S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512 665029002659 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 665029002660 methylthioribose kinase; Reviewed; Region: mtnK; PRK09550 665029002661 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 665029002662 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 665029002663 active site 665029002664 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 665029002665 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 665029002666 dimer interface [polypeptide binding]; other site 665029002667 active site 665029002668 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 665029002669 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 665029002670 putative active site [active] 665029002671 putative dimer interface [polypeptide binding]; other site 665029002672 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 665029002673 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 665029002674 active site 665029002675 DNA polymerase IV; Validated; Region: PRK02406 665029002676 DNA binding site [nucleotide binding] 665029002677 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 665029002678 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 665029002679 metal binding site [ion binding]; metal-binding site 665029002680 dimer interface [polypeptide binding]; other site 665029002681 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 665029002682 active site 665029002683 fermentation/respiration switch protein; Reviewed; Region: frsA; PRK05077 665029002684 DNA-binding transcriptional regulator Crl; Provisional; Region: PRK10984 665029002685 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 665029002686 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 665029002687 eyelet of channel; other site 665029002688 trimer interface [polypeptide binding]; other site 665029002689 gamma-glutamyl kinase; Provisional; Region: PRK05429 665029002690 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 665029002691 nucleotide binding site [chemical binding]; other site 665029002692 homotetrameric interface [polypeptide binding]; other site 665029002693 putative phosphate binding site [ion binding]; other site 665029002694 putative allosteric binding site; other site 665029002695 PUA domain; Region: PUA; pfam01472 665029002696 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 665029002697 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 665029002698 putative catalytic cysteine [active] 665029002699 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832 665029002700 chromosome condensation membrane protein; Provisional; Region: PRK14196 665029002701 anti-RssB factor; Provisional; Region: PRK10244 665029002702 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 665029002703 S-adenosylmethionine binding site [chemical binding]; other site 665029002704 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 665029002705 Acyltransferase family; Region: Acyl_transf_3; pfam01757 665029002706 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 665029002707 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 665029002708 Walker A/P-loop; other site 665029002709 ATP binding site [chemical binding]; other site 665029002710 Q-loop/lid; other site 665029002711 ABC transporter signature motif; other site 665029002712 Walker B; other site 665029002713 D-loop; other site 665029002714 H-loop/switch region; other site 665029002715 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 665029002716 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 665029002717 Walker A/P-loop; other site 665029002718 ATP binding site [chemical binding]; other site 665029002719 Q-loop/lid; other site 665029002720 ABC transporter signature motif; other site 665029002721 Walker B; other site 665029002722 D-loop; other site 665029002723 H-loop/switch region; other site 665029002724 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 665029002725 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 665029002726 dimer interface [polypeptide binding]; other site 665029002727 conserved gate region; other site 665029002728 ABC-ATPase subunit interface; other site 665029002729 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 665029002730 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 665029002731 dimer interface [polypeptide binding]; other site 665029002732 conserved gate region; other site 665029002733 putative PBP binding loops; other site 665029002734 ABC-ATPase subunit interface; other site 665029002735 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 665029002736 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 665029002737 CAAX protease self-immunity; Region: Abi; pfam02517 665029002738 Peptidase inhibitor I78 family; Region: Inhibitor_I78; pfam11720 665029002739 Biofilm development protein YmgB/AriR; Region: YmgB; pfam10798 665029002740 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 665029002741 DNA-binding site [nucleotide binding]; DNA binding site 665029002742 RNA-binding motif; other site 665029002743 beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525 665029002744 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 665029002745 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 665029002746 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 665029002747 Beta galactosidase small chain; Region: Bgal_small_N; smart01038 665029002748 psiF repeat; Region: PsiF_repeat; pfam07769 665029002749 psiF repeat; Region: PsiF_repeat; pfam07769 665029002750 Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases [Posttranslational modification, protein turnover, chaperones]; Region: COG3555 665029002751 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 665029002752 pyrroline-5-carboxylate reductase; Region: PLN02688 665029002753 hypothetical protein; Validated; Region: PRK00124 665029002754 Uncharacterized protein conserved in bacteria (DUF2076); Region: DUF2076; pfam09849 665029002755 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 665029002756 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 665029002757 ADP binding site [chemical binding]; other site 665029002758 magnesium binding site [ion binding]; other site 665029002759 putative shikimate binding site; other site 665029002760 hypothetical protein; Provisional; Region: PRK10380 665029002761 Transcriptional regulator [Transcription]; Region: IclR; COG1414 665029002762 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 665029002763 putative DNA binding site [nucleotide binding]; other site 665029002764 putative Zn2+ binding site [ion binding]; other site 665029002765 Bacterial transcriptional regulator; Region: IclR; pfam01614 665029002766 OPT oligopeptide transporter protein; Region: OPT; cl14607 665029002767 Protein of unknown function (DUF1177); Region: DUF1177; pfam06675 665029002768 hypothetical protein; Provisional; Region: PRK10481 665029002769 hypothetical protein; Provisional; Region: PRK10579 665029002770 recombination associated protein; Reviewed; Region: rdgC; PRK00321 665029002771 ethanolamine permease; Region: 2A0305; TIGR00908 665029002772 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 665029002773 active site 665029002774 substrate binding site [chemical binding]; other site 665029002775 Phosphotransferase enzyme family; Region: APH; pfam01636 665029002776 ATP binding site [chemical binding]; other site 665029002777 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 665029002778 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 665029002779 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 665029002780 TolA C-terminal; Region: TolA; pfam06519 665029002781 Curli production assembly/transport component CsgG; Region: CsgG; pfam03783 665029002782 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4259 665029002783 Putative bacterial lipoprotein (DUF799); Region: DUF799; cl01813 665029002784 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 665029002785 Walker A/P-loop; other site 665029002786 ATP binding site [chemical binding]; other site 665029002787 Q-loop/lid; other site 665029002788 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 665029002789 ABC transporter signature motif; other site 665029002790 Walker B; other site 665029002791 D-loop; other site 665029002792 H-loop/switch region; other site 665029002793 exonuclease subunit SbcD; Provisional; Region: PRK10966 665029002794 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 665029002795 active site 665029002796 metal binding site [ion binding]; metal-binding site 665029002797 DNA binding site [nucleotide binding] 665029002798 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 665029002799 transcriptional regulator PhoB; Provisional; Region: PRK10161 665029002800 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 665029002801 active site 665029002802 phosphorylation site [posttranslational modification] 665029002803 intermolecular recognition site; other site 665029002804 dimerization interface [polypeptide binding]; other site 665029002805 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 665029002806 DNA binding site [nucleotide binding] 665029002807 phosphate regulon sensor protein; Provisional; Region: phoR; PRK11006 665029002808 Domain of unknown function (DUF3329); Region: DUF3329; pfam11808 665029002809 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 665029002810 putative active site [active] 665029002811 heme pocket [chemical binding]; other site 665029002812 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 665029002813 dimer interface [polypeptide binding]; other site 665029002814 phosphorylation site [posttranslational modification] 665029002815 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 665029002816 ATP binding site [chemical binding]; other site 665029002817 Mg2+ binding site [ion binding]; other site 665029002818 G-X-G motif; other site 665029002819 PBP superfamily domain; Region: PBP_like_2; cl17296 665029002820 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 665029002821 substrate binding site [chemical binding]; other site 665029002822 THF binding site; other site 665029002823 zinc-binding site [ion binding]; other site 665029002824 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 665029002825 putative proline-specific permease; Provisional; Region: proY; PRK10580 665029002826 peroxidase; Provisional; Region: PRK15000 665029002827 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 665029002828 dimer interface [polypeptide binding]; other site 665029002829 decamer (pentamer of dimers) interface [polypeptide binding]; other site 665029002830 catalytic triad [active] 665029002831 peroxidatic and resolving cysteines [active] 665029002832 Protein of unknown function, DUF479; Region: DUF479; cl01203 665029002833 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 665029002834 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 665029002835 Glucosyl transferase GtrII; Region: Glucos_trans_II; cl10304 665029002836 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 665029002837 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 665029002838 Ligand binding site; other site 665029002839 Putative Catalytic site; other site 665029002840 DXD motif; other site 665029002841 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 665029002842 tRNA-guanine family transglycosylase; Region: tgt_general; TIGR00449 665029002843 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 665029002844 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 665029002845 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 665029002846 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 665029002847 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 665029002848 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 665029002849 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 665029002850 Protein export membrane protein; Region: SecD_SecF; pfam02355 665029002851 hypothetical protein; Provisional; Region: PRK11530 665029002852 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 665029002853 BON domain; Region: BON; pfam04972 665029002854 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 665029002855 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 665029002856 ATP cone domain; Region: ATP-cone; pfam03477 665029002857 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 665029002858 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 665029002859 catalytic motif [active] 665029002860 Zn binding site [ion binding]; other site 665029002861 RibD C-terminal domain; Region: RibD_C; cl17279 665029002862 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 665029002863 homopentamer interface [polypeptide binding]; other site 665029002864 active site 665029002865 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 665029002866 putative RNA binding site [nucleotide binding]; other site 665029002867 thiamine monophosphate kinase; Provisional; Region: PRK05731 665029002868 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 665029002869 ATP binding site [chemical binding]; other site 665029002870 dimerization interface [polypeptide binding]; other site 665029002871 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 665029002872 tetramer interfaces [polypeptide binding]; other site 665029002873 binuclear metal-binding site [ion binding]; other site 665029002874 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 665029002875 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 665029002876 TPP-binding site; other site 665029002877 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 665029002878 PYR/PP interface [polypeptide binding]; other site 665029002879 dimer interface [polypeptide binding]; other site 665029002880 TPP binding site [chemical binding]; other site 665029002881 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 665029002882 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 665029002883 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 665029002884 substrate binding pocket [chemical binding]; other site 665029002885 chain length determination region; other site 665029002886 substrate-Mg2+ binding site; other site 665029002887 catalytic residues [active] 665029002888 aspartate-rich region 1; other site 665029002889 active site lid residues [active] 665029002890 aspartate-rich region 2; other site 665029002891 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 665029002892 tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269 665029002893 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 665029002894 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 665029002895 Ligand Binding Site [chemical binding]; other site 665029002896 thiazole biosynthesis domain; Region: ThiI_C_thiazole; TIGR04271 665029002897 active site residue [active] 665029002898 oxidative-stress-resistance chaperone; Provisional; Region: PRK11574 665029002899 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 665029002900 conserved cys residue [active] 665029002901 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 665029002902 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 665029002903 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 665029002904 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 665029002905 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 665029002906 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 665029002907 Major Facilitator Superfamily; Region: MFS_1; pfam07690 665029002908 putative substrate translocation pore; other site 665029002909 protoheme IX farnesyltransferase; Provisional; Region: PRK13362 665029002910 UbiA prenyltransferase family; Region: UbiA; pfam01040 665029002911 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 665029002912 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 665029002913 Subunit I/III interface [polypeptide binding]; other site 665029002914 Subunit III/IV interface [polypeptide binding]; other site 665029002915 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 665029002916 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 665029002917 D-pathway; other site 665029002918 Putative ubiquinol binding site [chemical binding]; other site 665029002919 Low-spin heme (heme b) binding site [chemical binding]; other site 665029002920 Putative water exit pathway; other site 665029002921 Binuclear center (heme o3/CuB) [ion binding]; other site 665029002922 K-pathway; other site 665029002923 Putative proton exit pathway; other site 665029002924 cytochrome o ubiquinol oxidase subunit II; Provisional; Region: PRK10525 665029002925 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 665029002926 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 665029002927 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 665029002928 putative substrate translocation pore; other site 665029002929 hypothetical protein; Provisional; Region: PRK11627 665029002930 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 665029002931 Uncharacterized lipoprotein; Region: Lipoprotein_16; pfam03923 665029002932 transcriptional regulator BolA; Provisional; Region: PRK11628 665029002933 trigger factor; Provisional; Region: tig; PRK01490 665029002934 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 665029002935 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 665029002936 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 665029002937 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 665029002938 oligomer interface [polypeptide binding]; other site 665029002939 active site residues [active] 665029002940 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 665029002941 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 665029002942 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 665029002943 Walker A motif; other site 665029002944 ATP binding site [chemical binding]; other site 665029002945 Walker B motif; other site 665029002946 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 665029002947 Clp protease; Region: CLP_protease; pfam00574 665029002948 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 665029002949 oligomer interface [polypeptide binding]; other site 665029002950 active site residues [active] 665029002951 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 665029002952 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 665029002953 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 665029002954 Walker A motif; other site 665029002955 ATP binding site [chemical binding]; other site 665029002956 Walker B motif; other site 665029002957 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 665029002958 DNA-binding ATP-dependent protease La; Provisional; Region: PRK10787 665029002959 Found in ATP-dependent protease La (LON); Region: LON; smart00464 665029002960 Found in ATP-dependent protease La (LON); Region: LON; smart00464 665029002961 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 665029002962 Walker A motif; other site 665029002963 ATP binding site [chemical binding]; other site 665029002964 Walker B motif; other site 665029002965 arginine finger; other site 665029002966 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 665029002967 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 665029002968 IHF dimer interface [polypeptide binding]; other site 665029002969 IHF - DNA interface [nucleotide binding]; other site 665029002970 periplasmic folding chaperone; Provisional; Region: PRK10788 665029002971 SurA N-terminal domain; Region: SurA_N_3; cl07813 665029002972 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 665029002973 competence protein ComEA helix-hairpin-helix repeat region; Region: TIGR00426 665029002974 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 665029002975 active site 665029002976 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 665029002977 Ligand Binding Site [chemical binding]; other site 665029002978 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 665029002979 EamA-like transporter family; Region: EamA; pfam00892 665029002980 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 665029002981 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 665029002982 putative DNA binding site [nucleotide binding]; other site 665029002983 putative Zn2+ binding site [ion binding]; other site 665029002984 AsnC family; Region: AsnC_trans_reg; pfam01037 665029002985 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 665029002986 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 665029002987 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 665029002988 Walker A/P-loop; other site 665029002989 ATP binding site [chemical binding]; other site 665029002990 Q-loop/lid; other site 665029002991 ABC transporter signature motif; other site 665029002992 Walker B; other site 665029002993 D-loop; other site 665029002994 H-loop/switch region; other site 665029002995 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10790 665029002996 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 665029002997 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 665029002998 Walker A/P-loop; other site 665029002999 ATP binding site [chemical binding]; other site 665029003000 Q-loop/lid; other site 665029003001 ABC transporter signature motif; other site 665029003002 Walker B; other site 665029003003 D-loop; other site 665029003004 H-loop/switch region; other site 665029003005 nitrogen regulatory protein P-II 2; Provisional; Region: PRK10665 665029003006 Nitrogen regulatory protein P-II; Region: P-II; smart00938 665029003007 ammonium transporter; Provisional; Region: PRK10666 665029003008 acyl-CoA thioesterase II; Provisional; Region: PRK10526 665029003009 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 665029003010 active site 665029003011 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 665029003012 catalytic triad [active] 665029003013 dimer interface [polypeptide binding]; other site 665029003014 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3126 665029003015 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 665029003016 DNA binding site [nucleotide binding] 665029003017 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 665029003018 active site 665029003019 gene expression modulator; Provisional; Region: PRK10945 665029003020 Hha toxicity attenuator; Provisional; Region: PRK10667 665029003021 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 665029003022 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 665029003023 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 665029003024 Protein export membrane protein; Region: SecD_SecF; cl14618 665029003025 Protein export membrane protein; Region: SecD_SecF; cl14618 665029003026 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 665029003027 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 665029003028 HlyD family secretion protein; Region: HlyD_3; pfam13437 665029003029 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 665029003030 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 665029003031 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 665029003032 hypothetical protein; Provisional; Region: PRK11038 665029003033 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 665029003034 Primosomal replication protein priB and priC; Region: priB_priC; cl11483 665029003035 hypothetical protein; Provisional; Region: PRK10527 665029003036 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 665029003037 active site 665029003038 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994 665029003039 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 665029003040 Walker A motif; other site 665029003041 ATP binding site [chemical binding]; other site 665029003042 Walker B motif; other site 665029003043 arginine finger; other site 665029003044 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 665029003045 DNA polymerase III subunits tau domain IV DnaB-binding; Region: DNA_pol3_tau_4; pfam12168 665029003046 DNA polymerase III tau subunit V interacting with alpha; Region: DNA_pol3_tau_5; pfam12170 665029003047 hypothetical protein; Validated; Region: PRK00153 665029003048 recombination protein RecR; Reviewed; Region: recR; PRK00076 665029003049 RecR protein; Region: RecR; pfam02132 665029003050 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 665029003051 putative active site [active] 665029003052 putative metal-binding site [ion binding]; other site 665029003053 tetramer interface [polypeptide binding]; other site 665029003054 heat shock protein 90; Provisional; Region: PRK05218 665029003055 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 665029003056 ATP binding site [chemical binding]; other site 665029003057 Mg2+ binding site [ion binding]; other site 665029003058 G-X-G motif; other site 665029003059 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 665029003060 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 665029003061 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 665029003062 dimerization interface [polypeptide binding]; other site 665029003063 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 665029003064 Ligand Binding Site [chemical binding]; other site 665029003065 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 665029003066 nudix motif; other site 665029003067 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 665029003068 adenylate kinase; Reviewed; Region: adk; PRK00279 665029003069 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 665029003070 AMP-binding site [chemical binding]; other site 665029003071 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 665029003072 ferrochelatase; Reviewed; Region: hemH; PRK00035 665029003073 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 665029003074 C-terminal domain interface [polypeptide binding]; other site 665029003075 active site 665029003076 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 665029003077 active site 665029003078 N-terminal domain interface [polypeptide binding]; other site 665029003079 inosine/guanosine kinase; Provisional; Region: PRK15074 665029003080 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 665029003081 putative cation:proton antiport protein; Provisional; Region: PRK10669 665029003082 Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651 665029003083 TrkA-N domain; Region: TrkA_N; pfam02254 665029003084 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 665029003085 Major Facilitator Superfamily; Region: MFS_1; pfam07690 665029003086 putative substrate translocation pore; other site 665029003087 bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558 665029003088 Escherichia coli UshA and related proteins, N-terminal metallophosphatase domain; Region: MPP_UshA_N; cd07405 665029003089 active site 665029003090 metal binding site [ion binding]; metal-binding site 665029003091 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 665029003092 Predicted membrane protein [Function unknown]; Region: COG4125 665029003093 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 665029003094 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 665029003095 Transcriptional regulator [Transcription]; Region: LysR; COG0583 665029003096 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 665029003097 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 665029003098 dimerization interface [polypeptide binding]; other site 665029003099 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 665029003100 putative deacylase active site [active] 665029003101 TraB family; Region: TraB; cl12050 665029003102 copper exporting ATPase; Provisional; Region: copA; PRK10671 665029003103 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 665029003104 metal-binding site [ion binding] 665029003105 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 665029003106 metal-binding site [ion binding] 665029003107 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 665029003108 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 665029003109 motif II; other site 665029003110 DNA-binding transcriptional regulator CueR; Provisional; Region: PRK10227 665029003111 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 665029003112 DNA binding residues [nucleotide binding] 665029003113 dimer interface [polypeptide binding]; other site 665029003114 copper binding site [ion binding]; other site 665029003115 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 665029003116 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 665029003117 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 665029003118 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 665029003119 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 665029003120 oxidoreductase; Provisional; Region: PRK08017 665029003121 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 665029003122 NADP binding site [chemical binding]; other site 665029003123 active site 665029003124 steroid binding site; other site 665029003125 Colicin pore forming domain; Region: Colicin; pfam01024 665029003126 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 665029003127 active site 665029003128 catalytic triad [active] 665029003129 oxyanion hole [active] 665029003130 switch loop; other site 665029003131 putative ABC transporter ATP-binding protein YbbA; Provisional; Region: PRK10584 665029003132 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 665029003133 Walker A/P-loop; other site 665029003134 ATP binding site [chemical binding]; other site 665029003135 Q-loop/lid; other site 665029003136 ABC transporter signature motif; other site 665029003137 Walker B; other site 665029003138 D-loop; other site 665029003139 H-loop/switch region; other site 665029003140 FtsX-like permease family; Region: FtsX; pfam02687 665029003141 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 665029003142 ATP-grasp domain; Region: ATP-grasp; pfam02222 665029003143 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 665029003144 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 665029003145 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 665029003146 putative active site [active] 665029003147 putative metal binding site [ion binding]; other site 665029003148 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 665029003149 substrate binding site [chemical binding]; other site 665029003150 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 665029003151 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 665029003152 active site 665029003153 HIGH motif; other site 665029003154 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 665029003155 KMSKS motif; other site 665029003156 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 665029003157 tRNA binding surface [nucleotide binding]; other site 665029003158 anticodon binding site; other site 665029003159 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 665029003160 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 665029003161 NAD binding site [chemical binding]; other site 665029003162 substrate binding site [chemical binding]; other site 665029003163 catalytic Zn binding site [ion binding]; other site 665029003164 tetramer interface [polypeptide binding]; other site 665029003165 structural Zn binding site [ion binding]; other site 665029003166 ribosome-associated protein; Provisional; Region: PRK11507 665029003167 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792 665029003168 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 665029003169 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 665029003170 homodimer interface [polypeptide binding]; other site 665029003171 NADP binding site [chemical binding]; other site 665029003172 substrate binding site [chemical binding]; other site 665029003173 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 665029003174 Domain of unknown function (DUF3315); Region: DUF3315; cl02275 665029003175 Homocysteine/selenocysteine methylase (S-methylmethionine-dependent) [Amino acid transport and metabolism]; Region: MHT1; COG2040 665029003176 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 665029003177 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 665029003178 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 665029003179 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 665029003180 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 665029003181 dimer interface [polypeptide binding]; other site 665029003182 conserved gate region; other site 665029003183 putative PBP binding loops; other site 665029003184 ABC-ATPase subunit interface; other site 665029003185 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 665029003186 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 665029003187 dimer interface [polypeptide binding]; other site 665029003188 conserved gate region; other site 665029003189 ABC-ATPase subunit interface; other site 665029003190 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 665029003191 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 665029003192 Walker A/P-loop; other site 665029003193 ATP binding site [chemical binding]; other site 665029003194 Q-loop/lid; other site 665029003195 ABC transporter signature motif; other site 665029003196 Walker B; other site 665029003197 D-loop; other site 665029003198 H-loop/switch region; other site 665029003199 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 665029003200 Walker A/P-loop; other site 665029003201 ATP binding site [chemical binding]; other site 665029003202 Q-loop/lid; other site 665029003203 ABC transporter signature motif; other site 665029003204 Walker B; other site 665029003205 D-loop; other site 665029003206 H-loop/switch region; other site 665029003207 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 665029003208 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 665029003209 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 665029003210 N-terminal plug; other site 665029003211 ligand-binding site [chemical binding]; other site 665029003212 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 665029003213 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 665029003214 Trp docking motif [polypeptide binding]; other site 665029003215 putative active site [active] 665029003216 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 665029003217 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 665029003218 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 665029003219 inhibitor-cofactor binding pocket; inhibition site 665029003220 pyridoxal 5'-phosphate binding site [chemical binding]; other site 665029003221 catalytic residue [active] 665029003222 bifunctional UDP-glucuronic acid decarboxylase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase; Validated; Region: PRK08125 665029003223 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 665029003224 active site 665029003225 substrate binding site [chemical binding]; other site 665029003226 cosubstrate binding site; other site 665029003227 catalytic site [active] 665029003228 C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702 665029003229 active site 665029003230 hexamer interface [polypeptide binding]; other site 665029003231 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 665029003232 NAD binding site [chemical binding]; other site 665029003233 substrate binding site [chemical binding]; other site 665029003234 active site 665029003235 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD; Provisional; Region: PRK15394 665029003236 Catalytic domain of Escherichia coli 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD and other bacterial homologs; Region: CE4_ArnD; cd10939 665029003237 putative active site [active] 665029003238 putative catalytic site [active] 665029003239 putative Zn binding site [ion binding]; other site 665029003240 4-amino-4-deoxy-L-arabinose transferase; Provisional; Region: arnT; PRK13279 665029003241 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 665029003242 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051 665029003243 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971 665029003244 Bacterial protein of unknown function (DUF883); Region: DUF883; pfam05957 665029003245 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 665029003246 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 665029003247 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 665029003248 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 665029003249 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 665029003250 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 665029003251 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 665029003252 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 665029003253 putative aldolase; Validated; Region: PRK08130 665029003254 intersubunit interface [polypeptide binding]; other site 665029003255 active site 665029003256 Zn2+ binding site [ion binding]; other site 665029003257 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 665029003258 fructuronate transporter; Provisional; Region: PRK10034; cl15264 665029003259 fructuronate transporter; Provisional; Region: PRK10034; cl15264 665029003260 phospholipid:lipid A palmitoyltransferase; Provisional; Region: pagP; PRK11045 665029003261 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 665029003262 DNA-binding site [nucleotide binding]; DNA binding site 665029003263 RNA-binding motif; other site 665029003264 Predicted amidohydrolase [General function prediction only]; Region: COG0388 665029003265 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 665029003266 putative active site [active] 665029003267 catalytic triad [active] 665029003268 putative dimer interface [polypeptide binding]; other site 665029003269 twin arginine translocase protein E; Validated; Region: tatE; PRK03625 665029003270 lipoyl synthase; Provisional; Region: PRK05481 665029003271 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 665029003272 FeS/SAM binding site; other site 665029003273 lipoate-protein ligase B; Provisional; Region: PRK14342 665029003274 hypothetical protein; Provisional; Region: PRK04998 665029003275 D-alanyl-D-alanine carboxypeptidase fraction A; Provisional; Region: PRK10793 665029003276 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 665029003277 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 665029003278 rare lipoprotein A; Provisional; Region: PRK10672 665029003279 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 665029003280 Sporulation related domain; Region: SPOR; pfam05036 665029003281 cell wall shape-determining protein; Provisional; Region: PRK10794 665029003282 penicillin-binding protein 2; Provisional; Region: PRK10795 665029003283 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 665029003284 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 665029003285 rRNA large subunit m3Psi methyltransferase RlmH; Region: tRNA_RlmH_YbeA; TIGR00246 665029003286 ribosome-associated protein; Provisional; Region: PRK11538 665029003287 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 665029003288 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 665029003289 active site 665029003290 (T/H)XGH motif; other site 665029003291 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 665029003292 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 665029003293 LPS-assembly lipoprotein RlpB; Provisional; Region: PRK10796 665029003294 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 665029003295 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 665029003296 HIGH motif; other site 665029003297 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 665029003298 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 665029003299 active site 665029003300 KMSKS motif; other site 665029003301 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 665029003302 tRNA binding surface [nucleotide binding]; other site 665029003303 hypothetical protein; Provisional; Region: PRK11032 665029003304 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 665029003305 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 665029003306 Walker A/P-loop; other site 665029003307 ATP binding site [chemical binding]; other site 665029003308 Q-loop/lid; other site 665029003309 ABC transporter signature motif; other site 665029003310 Walker B; other site 665029003311 D-loop; other site 665029003312 H-loop/switch region; other site 665029003313 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 665029003314 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 665029003315 dimer interface [polypeptide binding]; other site 665029003316 conserved gate region; other site 665029003317 putative PBP binding loops; other site 665029003318 ABC-ATPase subunit interface; other site 665029003319 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 665029003320 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 665029003321 dimer interface [polypeptide binding]; other site 665029003322 conserved gate region; other site 665029003323 putative PBP binding loops; other site 665029003324 ABC-ATPase subunit interface; other site 665029003325 glutamate and aspartate transporter subunit; Provisional; Region: PRK10797 665029003326 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 665029003327 substrate binding pocket [chemical binding]; other site 665029003328 membrane-bound complex binding site; other site 665029003329 hinge residues; other site 665029003330 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 665029003331 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 665029003332 putative active site [active] 665029003333 catalytic triad [active] 665029003334 putative dimer interface [polypeptide binding]; other site 665029003335 magnesium/cobalt efflux protein CorC; Provisional; Region: PRK15094 665029003336 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 665029003337 Transporter associated domain; Region: CorC_HlyC; smart01091 665029003338 metal-binding heat shock protein; Provisional; Region: PRK00016 665029003339 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 665029003340 PhoH-like protein; Region: PhoH; pfam02562 665029003341 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 665029003342 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 665029003343 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 665029003344 FeS/SAM binding site; other site 665029003345 TRAM domain; Region: TRAM; pfam01938 665029003346 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Reviewed; Region: ubiF; PRK08020 665029003347 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 665029003348 potential protein location (hypothetical protein predicted by Glimmer/Critica [Erwinia amylovora]) that overlaps RNA (tRNA-Q) 665029003349 asparagine synthetase B; Provisional; Region: asnB; PRK09431 665029003350 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 665029003351 active site 665029003352 dimer interface [polypeptide binding]; other site 665029003353 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 665029003354 Ligand Binding Site [chemical binding]; other site 665029003355 Molecular Tunnel; other site 665029003356 UMP phosphatase; Provisional; Region: PRK10444 665029003357 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 665029003358 active site 665029003359 motif I; other site 665029003360 motif II; other site 665029003361 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 665029003362 MarR family; Region: MarR; pfam01047 665029003363 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 665029003364 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 665029003365 nucleotide binding site [chemical binding]; other site 665029003366 N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221 665029003367 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 665029003368 active site 665029003369 dimer interface [polypeptide binding]; other site 665029003370 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 665029003371 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 665029003372 active site 665029003373 trimer interface [polypeptide binding]; other site 665029003374 allosteric site; other site 665029003375 active site lid [active] 665029003376 hexamer (dimer of trimers) interface [polypeptide binding]; other site 665029003377 PTS system N-acetyl glucosamine specific transporter subunits IIABC; Provisional; Region: PRK10255 665029003378 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 665029003379 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 665029003380 active site turn [active] 665029003381 phosphorylation site [posttranslational modification] 665029003382 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 665029003383 HPr interaction site; other site 665029003384 glycerol kinase (GK) interaction site [polypeptide binding]; other site 665029003385 active site 665029003386 phosphorylation site [posttranslational modification] 665029003387 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 665029003388 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 665029003389 active site 665029003390 HIGH motif; other site 665029003391 nucleotide binding site [chemical binding]; other site 665029003392 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 665029003393 KMSKS motif; other site 665029003394 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 665029003395 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 665029003396 aromatic amino acid transport protein; Region: araaP; TIGR00837 665029003397 ferric uptake regulator; Provisional; Region: fur; PRK09462 665029003398 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 665029003399 metal binding site 2 [ion binding]; metal-binding site 665029003400 putative DNA binding helix; other site 665029003401 metal binding site 1 [ion binding]; metal-binding site 665029003402 dimer interface [polypeptide binding]; other site 665029003403 structural Zn2+ binding site [ion binding]; other site 665029003404 flavodoxin FldA; Validated; Region: PRK09267 665029003405 LexA regulated protein; Provisional; Region: PRK11675 665029003406 acyl-CoA esterase; Provisional; Region: PRK10673 665029003407 PGAP1-like protein; Region: PGAP1; pfam07819 665029003408 replication initiation regulator SeqA; Provisional; Region: PRK11187 665029003409 phosphoglucomutase; Validated; Region: PRK07564 665029003410 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 665029003411 active site 665029003412 substrate binding site [chemical binding]; other site 665029003413 metal binding site [ion binding]; metal-binding site 665029003414 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 665029003415 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 665029003416 active site 665029003417 phosphorylation site [posttranslational modification] 665029003418 intermolecular recognition site; other site 665029003419 dimerization interface [polypeptide binding]; other site 665029003420 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 665029003421 DNA binding site [nucleotide binding] 665029003422 Protein of unknown function (DUF2517); Region: DUF2517; pfam10725 665029003423 Protein of unknown function (DUF523); Region: DUF523; pfam04463 665029003424 Uncharacterized conserved protein [Function unknown]; Region: COG3272 665029003425 Protein of unknown function (DUF1722); Region: DUF1722; cl01284 665029003426 Uncharacterized conserved protein [Function unknown]; Region: COG0327 665029003427 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 665029003428 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 665029003429 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 665029003430 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 665029003431 LamB/YcsF family protein; Provisional; Region: PRK05406 665029003432 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 665029003433 putative substrate binding pocket [chemical binding]; other site 665029003434 AC domain interface; other site 665029003435 catalytic triad [active] 665029003436 AB domain interface; other site 665029003437 interchain disulfide; other site 665029003438 endonuclease VIII; Provisional; Region: PRK10445 665029003439 N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: FpgNei_N; cl03119 665029003440 DNA binding site [nucleotide binding] 665029003441 catalytic residue [active] 665029003442 H2TH interface [polypeptide binding]; other site 665029003443 putative catalytic residues [active] 665029003444 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 665029003445 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 665029003446 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 665029003447 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 665029003448 dimer interface [polypeptide binding]; other site 665029003449 active site 665029003450 citrylCoA binding site [chemical binding]; other site 665029003451 NADH binding [chemical binding]; other site 665029003452 cationic pore residues; other site 665029003453 oxalacetate/citrate binding site [chemical binding]; other site 665029003454 coenzyme A binding site [chemical binding]; other site 665029003455 catalytic triad [active] 665029003456 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 665029003457 Iron-sulfur protein interface; other site 665029003458 proximal quinone binding site [chemical binding]; other site 665029003459 SdhD (CybS) interface [polypeptide binding]; other site 665029003460 proximal heme binding site [chemical binding]; other site 665029003461 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 665029003462 SdhC subunit interface [polypeptide binding]; other site 665029003463 proximal heme binding site [chemical binding]; other site 665029003464 cardiolipin binding site; other site 665029003465 Iron-sulfur protein interface; other site 665029003466 proximal quinone binding site [chemical binding]; other site 665029003467 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08958 665029003468 L-aspartate oxidase; Provisional; Region: PRK06175 665029003469 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 665029003470 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 665029003471 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 665029003472 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 665029003473 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 665029003474 TPP-binding site [chemical binding]; other site 665029003475 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 665029003476 dimer interface [polypeptide binding]; other site 665029003477 PYR/PP interface [polypeptide binding]; other site 665029003478 TPP binding site [chemical binding]; other site 665029003479 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 665029003480 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 665029003481 E3 interaction surface; other site 665029003482 lipoyl attachment site [posttranslational modification]; other site 665029003483 e3 binding domain; Region: E3_binding; pfam02817 665029003484 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 665029003485 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 665029003486 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 665029003487 CoA-ligase; Region: Ligase_CoA; pfam00549 665029003488 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 665029003489 CoA binding domain; Region: CoA_binding; pfam02629 665029003490 CoA-ligase; Region: Ligase_CoA; pfam00549 665029003491 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 665029003492 active site 665029003493 colicin uptake protein TolQ; Provisional; Region: PRK10801 665029003494 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 665029003495 colicin uptake protein TolR; Provisional; Region: PRK11024 665029003496 cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510 665029003497 TolA C-terminal; Region: TolA; pfam06519 665029003498 translocation protein TolB; Provisional; Region: tolB; PRK03629 665029003499 TolB amino-terminal domain; Region: TolB_N; pfam04052 665029003500 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 665029003501 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 665029003502 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 665029003503 peptidoglycan-associated outer membrane lipoprotein; Provisional; Region: PRK10802 665029003504 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 665029003505 ligand binding site [chemical binding]; other site 665029003506 tol-pal system protein YbgF; Provisional; Region: PRK10803 665029003507 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 665029003508 TPR motif; other site 665029003509 binding surface 665029003510 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 665029003511 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 665029003512 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 665029003513 AlkA N-terminal domain; Region: AlkA_N; pfam06029 665029003514 3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308 665029003515 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 665029003516 minor groove reading motif; other site 665029003517 helix-hairpin-helix signature motif; other site 665029003518 substrate binding pocket [chemical binding]; other site 665029003519 active site 665029003520 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 665029003521 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 665029003522 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 665029003523 DNA binding site [nucleotide binding] 665029003524 active site 665029003525 Quinolinate synthetase A protein; Region: NadA; cl00420 665029003526 nicotinamide riboside transporter PnuC; Provisional; Region: PRK15397 665029003527 zinc transporter ZitB; Provisional; Region: PRK03557 665029003528 YbgS-like protein; Region: YbgS; pfam13985 665029003529 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 665029003530 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 665029003531 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 665029003532 RHS Repeat; Region: RHS_repeat; pfam05593 665029003533 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 665029003534 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 665029003535 catalytic core [active] 665029003536 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 665029003537 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 665029003538 active site 665029003539 catalytic residues [active] 665029003540 galactokinase; Provisional; Region: PRK05101 665029003541 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 665029003542 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 665029003543 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720 665029003544 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 665029003545 dimer interface [polypeptide binding]; other site 665029003546 active site 665029003547 putative molybdenum transport ATP-binding protein ModF; Provisional; Region: PRK10938 665029003548 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 665029003549 Walker A/P-loop; other site 665029003550 ATP binding site [chemical binding]; other site 665029003551 ABC transporter signature motif; other site 665029003552 Walker B; other site 665029003553 D-loop; other site 665029003554 H-loop/switch region; other site 665029003555 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 665029003556 Walker A/P-loop; other site 665029003557 ATP binding site [chemical binding]; other site 665029003558 Q-loop/lid; other site 665029003559 ABC transporter signature motif; other site 665029003560 Walker B; other site 665029003561 D-loop; other site 665029003562 H-loop/switch region; other site 665029003563 DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676 665029003564 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 665029003565 molybdenum-pterin binding domain; Region: Mop; TIGR00638 665029003566 Protein of unknown function (DUF2592); Region: DUF2592; pfam10766 665029003567 molybdate transporter periplasmic protein; Provisional; Region: modA; PRK10677 665029003568 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 665029003569 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 665029003570 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 665029003571 dimer interface [polypeptide binding]; other site 665029003572 conserved gate region; other site 665029003573 putative PBP binding loops; other site 665029003574 ABC-ATPase subunit interface; other site 665029003575 molybdate transporter ATP-binding protein; Provisional; Region: modC; PRK11144 665029003576 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 665029003577 Walker A/P-loop; other site 665029003578 ATP binding site [chemical binding]; other site 665029003579 Q-loop/lid; other site 665029003580 ABC transporter signature motif; other site 665029003581 Walker B; other site 665029003582 D-loop; other site 665029003583 H-loop/switch region; other site 665029003584 TOBE domain; Region: TOBE; cl01440 665029003585 pyridoxal phosphate (PLP) phosphatase; Provisional; Region: PRK10530 665029003586 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 665029003587 active site 665029003588 motif I; other site 665029003589 motif II; other site 665029003590 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 665029003591 6-phosphogluconolactonase; Provisional; Region: PRK11028 665029003592 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 665029003593 substrate binding site [chemical binding]; other site 665029003594 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 665029003595 Prostaglandin dehydrogenases; Region: PGDH; cd05288 665029003596 NAD(P) binding site [chemical binding]; other site 665029003597 substrate binding site [chemical binding]; other site 665029003598 dimer interface [polypeptide binding]; other site 665029003599 adenosylmethionine--8-amino-7-oxononanoate transaminase; Validated; Region: PRK07986 665029003600 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 665029003601 inhibitor-cofactor binding pocket; inhibition site 665029003602 pyridoxal 5'-phosphate binding site [chemical binding]; other site 665029003603 catalytic residue [active] 665029003604 biotin synthase; Provisional; Region: PRK15108 665029003605 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 665029003606 FeS/SAM binding site; other site 665029003607 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 665029003608 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 665029003609 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 665029003610 substrate-cofactor binding pocket; other site 665029003611 pyridoxal 5'-phosphate binding site [chemical binding]; other site 665029003612 catalytic residue [active] 665029003613 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 665029003614 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 665029003615 S-adenosylmethionine binding site [chemical binding]; other site 665029003616 AAA domain; Region: AAA_26; pfam13500 665029003617 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 665029003618 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 665029003619 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 665029003620 Walker A/P-loop; other site 665029003621 ATP binding site [chemical binding]; other site 665029003622 Q-loop/lid; other site 665029003623 ABC transporter signature motif; other site 665029003624 Walker B; other site 665029003625 D-loop; other site 665029003626 H-loop/switch region; other site 665029003627 excinuclease ABC subunit B; Provisional; Region: PRK05298 665029003628 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 665029003629 ATP binding site [chemical binding]; other site 665029003630 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 665029003631 nucleotide binding region [chemical binding]; other site 665029003632 ATP-binding site [chemical binding]; other site 665029003633 Ultra-violet resistance protein B; Region: UvrB; pfam12344 665029003634 UvrB/uvrC motif; Region: UVR; pfam02151 665029003635 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 665029003636 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 665029003637 phosphate binding site [ion binding]; other site 665029003638 putative substrate binding pocket [chemical binding]; other site 665029003639 dimer interface [polypeptide binding]; other site 665029003640 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 665029003641 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 665029003642 FeS/SAM binding site; other site 665029003643 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 665029003644 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 665029003645 MPT binding site; other site 665029003646 trimer interface [polypeptide binding]; other site 665029003647 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 665029003648 trimer interface [polypeptide binding]; other site 665029003649 dimer interface [polypeptide binding]; other site 665029003650 putative active site [active] 665029003651 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 665029003652 MoaE interaction surface [polypeptide binding]; other site 665029003653 MoeB interaction surface [polypeptide binding]; other site 665029003654 thiocarboxylated glycine; other site 665029003655 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 665029003656 MoaE homodimer interface [polypeptide binding]; other site 665029003657 MoaD interaction [polypeptide binding]; other site 665029003658 active site residues [active] 665029003659 Protein of unknown function (DUF1615); Region: DUF1615; pfam07759 665029003660 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 665029003661 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 665029003662 Putative inner membrane protein YbhQ; Region: YbhQ; pfam11076 665029003663 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 665029003664 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 665029003665 ATP binding site [chemical binding]; other site 665029003666 Mg++ binding site [ion binding]; other site 665029003667 motif III; other site 665029003668 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 665029003669 nucleotide binding region [chemical binding]; other site 665029003670 ATP-binding site [chemical binding]; other site 665029003671 tRNA-dihydrouridine synthase C; Provisional; Region: PRK10550 665029003672 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 665029003673 FMN binding site [chemical binding]; other site 665029003674 active site 665029003675 catalytic residues [active] 665029003676 substrate binding site [chemical binding]; other site 665029003677 L,D-transpeptidase; Provisional; Region: PRK10260 665029003678 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 665029003679 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 665029003680 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 665029003681 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 665029003682 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 665029003683 Protein of unknown function (DUF1282); Region: DUF1282; pfam06930 665029003684 D-alanyl-D-alanine endopeptidase; Provisional; Region: pbpG; PRK11669 665029003685 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 665029003686 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264 665029003687 Protein of unknown function (DUF3772); Region: DUF3772; pfam12607 665029003688 Mechanosensitive ion channel; Region: MS_channel; pfam00924 665029003689 D-lactate dehydrogenase; Provisional; Region: PRK11183 665029003690 FAD binding domain; Region: FAD_binding_4; pfam01565 665029003691 D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330 665029003692 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 665029003693 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 665029003694 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 665029003695 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 665029003696 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 665029003697 isopentenyl-diphosphate delta-isomerase, type 1; Region: IPP_isom_1; TIGR02150 665029003698 active site 665029003699 metal binding site [ion binding]; metal-binding site 665029003700 nudix motif; other site 665029003701 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 665029003702 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 665029003703 hypothetical protein; Provisional; Region: PRK13681 665029003704 Protein of unknown function (DUF3833); Region: DUF3833; pfam12915 665029003705 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 665029003706 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 665029003707 S-adenosylmethionine binding site [chemical binding]; other site 665029003708 Protein of unknown function (DUF1365); Region: DUF1365; pfam07103 665029003709 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 665029003710 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 665029003711 short chain dehydrogenase; Provisional; Region: PRK06101 665029003712 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 665029003713 NAD(P) binding site [chemical binding]; other site 665029003714 active site 665029003715 SnoaL-like domain; Region: SnoaL_2; pfam12680 665029003716 transcriptional regulator MirA; Provisional; Region: PRK15043 665029003717 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 665029003718 DNA binding residues [nucleotide binding] 665029003719 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 665029003720 Coenzyme A binding pocket [chemical binding]; other site 665029003721 ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747 665029003722 DEAD_2; Region: DEAD_2; pfam06733 665029003723 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 665029003724 glycosyl transferase family protein; Provisional; Region: PRK08136 665029003725 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 665029003726 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 665029003727 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 665029003728 metal binding site [ion binding]; metal-binding site 665029003729 putative dimer interface [polypeptide binding]; other site 665029003730 urocanate hydratase; Provisional; Region: PRK05414 665029003731 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 665029003732 active sites [active] 665029003733 tetramer interface [polypeptide binding]; other site 665029003734 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 665029003735 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 665029003736 DNA-binding site [nucleotide binding]; DNA binding site 665029003737 UTRA domain; Region: UTRA; pfam07702 665029003738 HutD; Region: HutD; cl01532 665029003739 N-formimino-L-glutamate deiminase; Validated; Region: PRK09229 665029003740 Metallo-dependent hydrolases, subgroup D is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_E; cd01313 665029003741 active site 665029003742 imidazolonepropionase; Validated; Region: PRK09356 665029003743 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 665029003744 active site 665029003745 N-formylglutamate amidohydrolase; Region: FGase; cl01522 665029003746 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C); Region: NT5C; cl17836 665029003747 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 665029003748 Aspartyl protease; Region: Asp_protease_2; pfam13650 665029003749 Cellular and retroviral pepsin-like aspartate proteases; Region: pepsin_retropepsin_like; cl11403 665029003750 inhibitor binding site; inhibition site 665029003751 catalytic motif [active] 665029003752 Catalytic residue [active] 665029003753 Active site flap [active] 665029003754 potential frameshift: common BLAST hit: gi|192361456|ref|YP_001980791.1| radical SAM domain protein protein 665029003755 Domain of unknown function (DUF4008); Region: DUF4008; cl14869 665029003756 radical SAM/SPASM domain, FxsB family; Region: SAM_SPASM_FxsB; TIGR04269 665029003757 23S rRNA mA1618 methyltransferase; Provisional; Region: PRK11727 665029003758 Protein of unknown function (DUF890); Region: Methyltransf_10; pfam05971 665029003759 putative mechanosensitive channel protein; Provisional; Region: PRK11465 665029003760 Mechanosensitive ion channel; Region: MS_channel; pfam00924 665029003761 glutamine ABC transporter ATP-binding protein; Reviewed; Region: glnQ; PRK09493 665029003762 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 665029003763 Walker A/P-loop; other site 665029003764 ATP binding site [chemical binding]; other site 665029003765 Q-loop/lid; other site 665029003766 ABC transporter signature motif; other site 665029003767 Walker B; other site 665029003768 D-loop; other site 665029003769 H-loop/switch region; other site 665029003770 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 665029003771 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 665029003772 dimer interface [polypeptide binding]; other site 665029003773 conserved gate region; other site 665029003774 putative PBP binding loops; other site 665029003775 ABC-ATPase subunit interface; other site 665029003776 glutamine ABC transporter periplasmic protein; Reviewed; Region: glnH; PRK09495 665029003777 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 665029003778 substrate binding pocket [chemical binding]; other site 665029003779 membrane-bound complex binding site; other site 665029003780 hinge residues; other site 665029003781 hypothetical protein; Provisional; Region: PRK11019 665029003782 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 665029003783 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 665029003784 dimerization interface [polypeptide binding]; other site 665029003785 DPS ferroxidase diiron center [ion binding]; other site 665029003786 ion pore; other site 665029003787 threonine and homoserine efflux system; Provisional; Region: PRK10532 665029003788 EamA-like transporter family; Region: EamA; pfam00892 665029003789 outer membrane protein X; Provisional; Region: ompX; PRK09408 665029003790 manganese transport regulator MntR; Provisional; Region: PRK11050 665029003791 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 665029003792 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 665029003793 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 665029003794 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 665029003795 HlyD family secretion protein; Region: HlyD_3; pfam13437 665029003796 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 665029003797 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 665029003798 putative substrate translocation pore; other site 665029003799 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 665029003800 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 665029003801 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 665029003802 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 665029003803 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 665029003804 putative substrate translocation pore; other site 665029003805 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 665029003806 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 665029003807 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 665029003808 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 665029003809 Walker A/P-loop; other site 665029003810 ATP binding site [chemical binding]; other site 665029003811 ABC transporter signature motif; other site 665029003812 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 665029003813 Walker B; other site 665029003814 ABC transporter; Region: ABC_tran_2; pfam12848 665029003815 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 665029003816 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 665029003817 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 665029003818 ATP binding site [chemical binding]; other site 665029003819 substrate interface [chemical binding]; other site 665029003820 molybdopterin biosynthesis protein MoeA; Provisional; Region: PRK10680 665029003821 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 665029003822 dimer interface [polypeptide binding]; other site 665029003823 putative functional site; other site 665029003824 putative MPT binding site; other site 665029003825 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 665029003826 catalytic nucleophile [active] 665029003827 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 665029003828 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 665029003829 Walker A/P-loop; other site 665029003830 ATP binding site [chemical binding]; other site 665029003831 Q-loop/lid; other site 665029003832 ABC transporter signature motif; other site 665029003833 Walker B; other site 665029003834 D-loop; other site 665029003835 H-loop/switch region; other site 665029003836 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 665029003837 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 665029003838 Walker A/P-loop; other site 665029003839 ATP binding site [chemical binding]; other site 665029003840 Q-loop/lid; other site 665029003841 ABC transporter signature motif; other site 665029003842 Walker B; other site 665029003843 D-loop; other site 665029003844 H-loop/switch region; other site 665029003845 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 665029003846 glutathione ABC transporter substrate-binding protein GsiB; Provisional; Region: PRK15413 665029003847 The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499 665029003848 glutathione ABC transporter permease GsiC; Provisional; Region: PRK15081 665029003849 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 665029003850 dimer interface [polypeptide binding]; other site 665029003851 conserved gate region; other site 665029003852 putative PBP binding loops; other site 665029003853 ABC-ATPase subunit interface; other site 665029003854 glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082 665029003855 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 665029003856 dimer interface [polypeptide binding]; other site 665029003857 conserved gate region; other site 665029003858 putative PBP binding loops; other site 665029003859 ABC-ATPase subunit interface; other site 665029003860 potential protein location (hypothetical protein predicted by Glimmer/Critica) that overlaps protein (hypothetical protein predicted by Glimmer/Critica) 665029003861 potential protein location (hypothetical protein predicted by Glimmer/Critica) that overlaps protein (hypothetical protein predicted by Glimmer/Critica) 665029003862 D-alanyl-D-alanine carboxypeptidase fraction C; Provisional; Region: PRK10001 665029003863 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 665029003864 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 665029003865 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 665029003866 serine transporter; Region: stp; TIGR00814 665029003867 PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396 665029003868 active site 665029003869 putative transporter; Provisional; Region: PRK04972 665029003870 Predicted Permease Membrane Region; Region: Asp-Al_Ex; cl06061 665029003871 TrkA-C domain; Region: TrkA_C; pfam02080 665029003872 TrkA-C domain; Region: TrkA_C; pfam02080 665029003873 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 665029003874 Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066 665029003875 GSH binding site [chemical binding]; other site 665029003876 catalytic residues [active] 665029003877 hypothetical protein; Provisional; Region: PRK10591 665029003878 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 665029003879 dimer interface [polypeptide binding]; other site 665029003880 FMN binding site [chemical binding]; other site 665029003881 NADPH bind site [chemical binding]; other site 665029003882 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 665029003883 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 665029003884 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 665029003885 putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607 665029003886 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 665029003887 Walker A/P-loop; other site 665029003888 ATP binding site [chemical binding]; other site 665029003889 Q-loop/lid; other site 665029003890 ABC transporter signature motif; other site 665029003891 Walker B; other site 665029003892 D-loop; other site 665029003893 H-loop/switch region; other site 665029003894 TOBE domain; Region: TOBE_2; pfam08402 665029003895 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 665029003896 dimer interface [polypeptide binding]; other site 665029003897 conserved gate region; other site 665029003898 putative PBP binding loops; other site 665029003899 ABC-ATPase subunit interface; other site 665029003900 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 665029003901 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 665029003902 dimer interface [polypeptide binding]; other site 665029003903 conserved gate region; other site 665029003904 putative PBP binding loops; other site 665029003905 ABC-ATPase subunit interface; other site 665029003906 Protein of unknown function (DUF2593); Region: DUF2593; pfam10767 665029003907 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 665029003908 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 665029003909 substrate binding pocket [chemical binding]; other site 665029003910 membrane-bound complex binding site; other site 665029003911 hinge residues; other site 665029003912 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 665029003913 dimer interface [polypeptide binding]; other site 665029003914 conserved gate region; other site 665029003915 putative PBP binding loops; other site 665029003916 ABC-ATPase subunit interface; other site 665029003917 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 665029003918 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 665029003919 dimer interface [polypeptide binding]; other site 665029003920 conserved gate region; other site 665029003921 putative PBP binding loops; other site 665029003922 ABC-ATPase subunit interface; other site 665029003923 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 665029003924 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 665029003925 substrate binding pocket [chemical binding]; other site 665029003926 membrane-bound complex binding site; other site 665029003927 hinge residues; other site 665029003928 arginine transporter ATP-binding subunit; Provisional; Region: artP; PRK11124 665029003929 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 665029003930 Walker A/P-loop; other site 665029003931 ATP binding site [chemical binding]; other site 665029003932 Q-loop/lid; other site 665029003933 ABC transporter signature motif; other site 665029003934 Walker B; other site 665029003935 D-loop; other site 665029003936 H-loop/switch region; other site 665029003937 putative lipoprotein; Provisional; Region: PRK10533 665029003938 hypothetical protein; Provisional; Region: PRK02877 665029003939 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 665029003940 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 665029003941 amidase catalytic site [active] 665029003942 Zn binding residues [ion binding]; other site 665029003943 substrate binding site [chemical binding]; other site 665029003944 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 665029003945 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 665029003946 tetramer interface [polypeptide binding]; other site 665029003947 pyridoxal 5'-phosphate binding site [chemical binding]; other site 665029003948 catalytic residue [active] 665029003949 pyruvate dehydrogenase; Provisional; Region: PRK09124 665029003950 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 665029003951 PYR/PP interface [polypeptide binding]; other site 665029003952 dimer interface [polypeptide binding]; other site 665029003953 tetramer interface [polypeptide binding]; other site 665029003954 TPP binding site [chemical binding]; other site 665029003955 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 665029003956 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 665029003957 TPP-binding site [chemical binding]; other site 665029003958 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 665029003959 Protein of unknown function (DUF2813); Region: DUF2813; pfam11398 665029003960 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 665029003961 putative active site [active] 665029003962 putative metal-binding site [ion binding]; other site 665029003963 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 665029003964 DNA-binding site [nucleotide binding]; DNA binding site 665029003965 RNA-binding motif; other site 665029003966 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 665029003967 ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034 665029003968 Clp amino terminal domain; Region: Clp_N; pfam02861 665029003969 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 665029003970 Walker A motif; other site 665029003971 ATP binding site [chemical binding]; other site 665029003972 Walker B motif; other site 665029003973 arginine finger; other site 665029003974 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 665029003975 Walker A motif; other site 665029003976 ATP binding site [chemical binding]; other site 665029003977 Walker B motif; other site 665029003978 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 665029003979 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 665029003980 rRNA binding site [nucleotide binding]; other site 665029003981 predicted 30S ribosome binding site; other site 665029003982 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 665029003983 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160 665029003984 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 665029003985 Walker A/P-loop; other site 665029003986 ATP binding site [chemical binding]; other site 665029003987 Q-loop/lid; other site 665029003988 ABC transporter signature motif; other site 665029003989 Walker B; other site 665029003990 D-loop; other site 665029003991 H-loop/switch region; other site 665029003992 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11174 665029003993 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 665029003994 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 665029003995 Walker A/P-loop; other site 665029003996 ATP binding site [chemical binding]; other site 665029003997 Q-loop/lid; other site 665029003998 ABC transporter signature motif; other site 665029003999 Walker B; other site 665029004000 D-loop; other site 665029004001 H-loop/switch region; other site 665029004002 thioredoxin reductase; Provisional; Region: PRK10262 665029004003 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 665029004004 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 665029004005 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 665029004006 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 665029004007 putative DNA binding site [nucleotide binding]; other site 665029004008 putative Zn2+ binding site [ion binding]; other site 665029004009 AsnC family; Region: AsnC_trans_reg; pfam01037 665029004010 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 665029004011 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 665029004012 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 665029004013 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 665029004014 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 665029004015 recombination factor protein RarA; Reviewed; Region: PRK13342 665029004016 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 665029004017 Walker A motif; other site 665029004018 ATP binding site [chemical binding]; other site 665029004019 Walker B motif; other site 665029004020 arginine finger; other site 665029004021 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 665029004022 seryl-tRNA synthetase; Provisional; Region: PRK05431 665029004023 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 665029004024 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 665029004025 dimer interface [polypeptide binding]; other site 665029004026 active site 665029004027 motif 1; other site 665029004028 motif 2; other site 665029004029 motif 3; other site 665029004030 putative MFS family transporter protein; Provisional; Region: PRK03633 665029004031 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 665029004032 putative substrate translocation pore; other site 665029004033 pyruvate formate lyase-activating enzyme 1; Provisional; Region: pflA; PRK11145 665029004034 uncharacterized domain; Region: TIGR00702 665029004035 YcaO-like family; Region: YcaO; pfam02624 665029004036 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 665029004037 homodimer interface [polypeptide binding]; other site 665029004038 substrate-cofactor binding pocket; other site 665029004039 pyridoxal 5'-phosphate binding site [chemical binding]; other site 665029004040 catalytic residue [active] 665029004041 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 665029004042 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 665029004043 hinge; other site 665029004044 active site 665029004045 cytidylate kinase; Provisional; Region: cmk; PRK00023 665029004046 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 665029004047 CMP-binding site; other site 665029004048 The sites determining sugar specificity; other site 665029004049 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 665029004050 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 665029004051 RNA binding site [nucleotide binding]; other site 665029004052 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 665029004053 RNA binding site [nucleotide binding]; other site 665029004054 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689 665029004055 RNA binding site [nucleotide binding]; other site 665029004056 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 665029004057 RNA binding site [nucleotide binding]; other site 665029004058 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 665029004059 RNA binding site [nucleotide binding]; other site 665029004060 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 665029004061 IHF dimer interface [polypeptide binding]; other site 665029004062 IHF - DNA interface [nucleotide binding]; other site 665029004063 ComEC family competence protein; Provisional; Region: PRK11539 665029004064 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 665029004065 Competence protein; Region: Competence; pfam03772 665029004066 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 665029004067 lipid transporter ATP-binding/permease protein; Provisional; Region: PRK11176 665029004068 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 665029004069 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 665029004070 Walker A/P-loop; other site 665029004071 ATP binding site [chemical binding]; other site 665029004072 Q-loop/lid; other site 665029004073 ABC transporter signature motif; other site 665029004074 Walker B; other site 665029004075 D-loop; other site 665029004076 H-loop/switch region; other site 665029004077 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 665029004078 tetraacyldisaccharide 4'-kinase; Region: lpxK; TIGR00682 665029004079 Trm112p-like protein; Region: Trm112p; cl01066 665029004080 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 665029004081 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 665029004082 Ligand binding site; other site 665029004083 oligomer interface; other site 665029004084 hypothetical protein; Provisional; Region: PRK10593 665029004085 Uncharacterized conserved protein [Function unknown]; Region: COG1434 665029004086 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 665029004087 putative active site [active] 665029004088 Methyltransferase domain; Region: Methyltransf_23; pfam13489 665029004089 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 665029004090 S-adenosylmethionine binding site [chemical binding]; other site 665029004091 condesin subunit F; Provisional; Region: PRK05260 665029004092 condesin subunit E; Provisional; Region: PRK05256 665029004093 cell division protein MukB; Provisional; Region: mukB; PRK04863 665029004094 P-loop containing region of AAA domain; Region: AAA_29; cl17516 665029004095 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 665029004096 murein L,D-transpeptidase; Provisional; Region: PRK10594 665029004097 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 665029004098 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 665029004099 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 665029004100 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 665029004101 Peptidase M15; Region: Peptidase_M15_3; cl01194 665029004102 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 665029004103 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 665029004104 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 665029004105 pyridoxal 5'-phosphate binding site [chemical binding]; other site 665029004106 homodimer interface [polypeptide binding]; other site 665029004107 catalytic residue [active] 665029004108 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 665029004109 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 665029004110 trimer interface [polypeptide binding]; other site 665029004111 eyelet of channel; other site 665029004112 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 665029004113 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 665029004114 putative dimer interface [polypeptide binding]; other site 665029004115 putative anticodon binding site; other site 665029004116 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 665029004117 homodimer interface [polypeptide binding]; other site 665029004118 motif 1; other site 665029004119 motif 2; other site 665029004120 active site 665029004121 motif 3; other site 665029004122 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 665029004123 Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401 665029004124 active site 665029004125 aminopeptidase N; Provisional; Region: pepN; PRK14015 665029004126 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 665029004127 active site 665029004128 Zn binding site [ion binding]; other site 665029004129 aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247 665029004130 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 665029004131 Walker A/P-loop; other site 665029004132 ATP binding site [chemical binding]; other site 665029004133 Q-loop/lid; other site 665029004134 ABC transporter signature motif; other site 665029004135 Walker B; other site 665029004136 D-loop; other site 665029004137 H-loop/switch region; other site 665029004138 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 665029004139 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 665029004140 dimer interface [polypeptide binding]; other site 665029004141 conserved gate region; other site 665029004142 putative PBP binding loops; other site 665029004143 ABC-ATPase subunit interface; other site 665029004144 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 665029004145 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 665029004146 active site 665029004147 dimer interface [polypeptide binding]; other site 665029004148 non-prolyl cis peptide bond; other site 665029004149 insertion regions; other site 665029004150 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 665029004151 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 665029004152 substrate binding pocket [chemical binding]; other site 665029004153 membrane-bound complex binding site; other site 665029004154 hinge residues; other site 665029004155 NAD(P)H-dependent FMN reductase; Provisional; Region: PRK10569 665029004156 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 665029004157 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 665029004158 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 665029004159 quinone interaction residues [chemical binding]; other site 665029004160 active site 665029004161 catalytic residues [active] 665029004162 FMN binding site [chemical binding]; other site 665029004163 substrate binding site [chemical binding]; other site 665029004164 Protein of unknown function (DUF1379); Region: DUF1379; pfam07126 665029004165 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 665029004166 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 665029004167 MOSC domain; Region: MOSC; pfam03473 665029004168 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 665029004169 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 665029004170 catalytic loop [active] 665029004171 iron binding site [ion binding]; other site 665029004172 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 665029004173 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 665029004174 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 665029004175 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 665029004176 S-adenosylmethionine binding site [chemical binding]; other site 665029004177 ABC transporter ATPase component; Reviewed; Region: PRK11147 665029004178 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 665029004179 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 665029004180 ABC transporter; Region: ABC_tran_2; pfam12848 665029004181 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 665029004182 paraquat-inducible membrane protein A; Provisional; Region: PRK15103 665029004183 Paraquat-inducible protein A; Region: PqiA; pfam04403 665029004184 Paraquat-inducible protein A; Region: PqiA; pfam04403 665029004185 paraquat-inducible protein B; Provisional; Region: PRK10807 665029004186 mce related protein; Region: MCE; pfam02470 665029004187 mce related protein; Region: MCE; pfam02470 665029004188 mce related protein; Region: MCE; pfam02470 665029004189 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009 665029004190 Protein of unknown function (DUF330); Region: DUF330; pfam03886 665029004191 Ribosome modulation factor; Region: RMF; pfam04957 665029004192 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 665029004193 active site 1 [active] 665029004194 dimer interface [polypeptide binding]; other site 665029004195 active site 2 [active] 665029004196 Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067 665029004197 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 665029004198 Ter macrodomain organizer matS-binding protein; Provisional; Region: PRK05097 665029004199 outer membrane protein A; Reviewed; Region: PRK10808 665029004200 OmpA-like transmembrane domain; Region: OmpA_membrane; pfam01389 665029004201 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 665029004202 ligand binding site [chemical binding]; other site 665029004203 SOS cell division inhibitor; Provisional; Region: PRK10595 665029004204 TfoX N-terminal domain; Region: TfoX_N; pfam04993 665029004205 TfoX C-terminal domain; Region: TfoX_C; pfam04994 665029004206 TIGR01666 family membrane protein; Region: YCCS 665029004207 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 665029004208 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 665029004209 hypothetical protein; Provisional; Region: PRK11770 665029004210 Domain of unknown function (DUF307); Region: DUF307; pfam03733 665029004211 Domain of unknown function (DUF307); Region: DUF307; pfam03733 665029004212 DNA helicase IV; Provisional; Region: helD; PRK11054 665029004213 DNA helicase IV / RNA helicase N terminal; Region: Nucleolin_N; pfam12462 665029004214 Part of AAA domain; Region: AAA_19; pfam13245 665029004215 Family description; Region: UvrD_C_2; pfam13538 665029004216 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 665029004217 active site 665029004218 dimer interfaces [polypeptide binding]; other site 665029004219 catalytic residues [active] 665029004220 Uncharacterized protein conserved in bacteria (DUF2057); Region: DUF2057; cl11437 665029004221 heat shock protein HspQ; Provisional; Region: PRK14129 665029004222 23S rRNA m(5)C1962 methyltransferase; Provisional; Region: PRK15128 665029004223 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 665029004224 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 665029004225 putative RNA binding site [nucleotide binding]; other site 665029004226 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 665029004227 S-adenosylmethionine binding site [chemical binding]; other site 665029004228 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920 665029004229 sulfur relay protein, TusE/DsrC/DsvC family; Region: dsrC_tusE_dsvC; TIGR03342 665029004230 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 665029004231 YccA-like proteins; Region: YccA_like; cd10433 665029004232 glucose-1-phosphatase/inositol phosphatase; Provisional; Region: PRK10173 665029004233 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 665029004234 catalytic core [active] 665029004235 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 665029004236 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 665029004237 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 665029004238 NAD(P) binding site [chemical binding]; other site 665029004239 catalytic residues [active] 665029004240 hypothetical protein; Provisional; Region: PRK10174 665029004241 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 665029004242 EamA-like transporter family; Region: EamA; pfam00892 665029004243 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 665029004244 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 665029004245 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 665029004246 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 665029004247 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 665029004248 DNA-binding transcriptional activator SdiA; Provisional; Region: PRK10188 665029004249 Autoinducer binding domain; Region: Autoind_bind; pfam03472 665029004250 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 665029004251 DNA binding residues [nucleotide binding] 665029004252 dimerization interface [polypeptide binding]; other site 665029004253 Autoinducer synthetase; Region: Autoind_synth; cl17404 665029004254 GlpM protein; Region: GlpM; pfam06942 665029004255 hypothetical protein; Provisional; Region: PRK10613 665029004256 response regulator; Provisional; Region: PRK09483 665029004257 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 665029004258 active site 665029004259 phosphorylation site [posttranslational modification] 665029004260 intermolecular recognition site; other site 665029004261 dimerization interface [polypeptide binding]; other site 665029004262 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 665029004263 DNA binding residues [nucleotide binding] 665029004264 dimerization interface [polypeptide binding]; other site 665029004265 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 665029004266 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 665029004267 GIY-YIG motif/motif A; other site 665029004268 active site 665029004269 catalytic site [active] 665029004270 putative DNA binding site [nucleotide binding]; other site 665029004271 metal binding site [ion binding]; metal-binding site 665029004272 UvrB/uvrC motif; Region: UVR; pfam02151 665029004273 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 665029004274 phosphatidylglycerophosphate synthetase; Provisional; Region: PRK10832 665029004275 Transposase; Region: HTH_Tnp_1; cl17663 665029004276 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 665029004277 MarR family; Region: MarR; pfam01047 665029004278 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 665029004279 Major Facilitator Superfamily; Region: MFS_1; pfam07690 665029004280 putative substrate translocation pore; other site 665029004281 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 665029004282 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 665029004283 HlyD family secretion protein; Region: HlyD_3; pfam13437 665029004284 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 665029004285 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 665029004286 PLD-like domain; Region: PLDc_2; pfam13091 665029004287 putative active site [active] 665029004288 catalytic site [active] 665029004289 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 665029004290 PLD-like domain; Region: PLDc_2; pfam13091 665029004291 putative active site [active] 665029004292 catalytic site [active] 665029004293 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 665029004294 Acyltransferase family; Region: Acyl_transf_3; pfam01757 665029004295 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 665029004296 Periplasmic glucan biosynthesis protein, MdoG; Region: MdoG; cl15433 665029004297 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 665029004298 Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191 665029004299 Ligand binding site; other site 665029004300 DXD motif; other site 665029004301 lipoprotein; Provisional; Region: PRK10175 665029004302 secY/secA suppressor protein; Provisional; Region: PRK11467 665029004303 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 665029004304 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 665029004305 putative acyl-acceptor binding pocket; other site 665029004306 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 665029004307 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 665029004308 active site residue [active] 665029004309 hypothetical protein; Provisional; Region: PRK03757 665029004310 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 665029004311 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 665029004312 hydroxyglutarate oxidase; Provisional; Region: PRK11728 665029004313 biofilm formation regulatory protein BssS; Reviewed; Region: bssS; PRK12301 665029004314 DNA damage-inducible protein I; Provisional; Region: PRK10597 665029004315 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 665029004316 active site 665029004317 substrate binding pocket [chemical binding]; other site 665029004318 dimer interface [polypeptide binding]; other site 665029004319 lipoprotein; Provisional; Region: PRK10598 665029004320 glutaredoxin 2; Provisional; Region: PRK10387 665029004321 GST_N family, Glutaredoxin 2 (GRX2) subfamily; composed of bacterial proteins similar to E. coli GRX2, an atypical GRX with a molecular mass of about 24kD, compared with other GRXs which are 9-12kD in size. GRX2 adopts a GST fold containing an N-terminal...; Region: GST_N_GRX2; cd03037 665029004322 C-terminal domain interface [polypeptide binding]; other site 665029004323 GSH binding site (G-site) [chemical binding]; other site 665029004324 catalytic residues [active] 665029004325 putative dimer interface [polypeptide binding]; other site 665029004326 C-terminal, alpha helical domain of Glutaredoxin 2; Region: GST_C_GRX2; cd03199 665029004327 N-terminal domain interface [polypeptide binding]; other site 665029004328 ribosomal-protein-S5-alanine N-acetyltransferase; Provisional; Region: PRK10809 665029004329 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 665029004330 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 665029004331 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 665029004332 FlgN protein; Region: FlgN; cl09176 665029004333 anti-sigma28 factor FlgM; Provisional; Region: PRK10810 665029004334 SAF-like; Region: SAF_2; pfam13144 665029004335 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 665029004336 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 665029004337 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 665029004338 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 665029004339 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 665029004340 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 665029004341 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655 665029004342 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 665029004343 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 665029004344 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 665029004345 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 665029004346 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 665029004347 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 665029004348 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640 665029004349 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 665029004350 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 665029004351 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 665029004352 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 665029004353 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 665029004354 Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063 665029004355 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 665029004356 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 665029004357 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 665029004358 flagellar rod assembly protein/muramidase FlgJ; Validated; Region: flgJ; PRK05684 665029004359 Rod binding protein [Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3951 665029004360 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 665029004361 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK08147 665029004362 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 665029004363 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08027 665029004364 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 665029004365 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 665029004366 potential protein location (hypothetical protein predicted by Glimmer/Critica) that overlaps protein (hypothetical protein predicted by Glimmer/Critica) 665029004367 potential protein location (hypothetical protein predicted by Glimmer/Critica) that overlaps protein (hypothetical protein predicted by Glimmer/Critica) 665029004368 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 665029004369 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 665029004370 homodimer interface [polypeptide binding]; other site 665029004371 oligonucleotide binding site [chemical binding]; other site 665029004372 Polyribonucleotide phosphorylase C terminal; Region: PNPase_C; pfam12111 665029004373 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 665029004374 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 665029004375 RNA binding surface [nucleotide binding]; other site 665029004376 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 665029004377 active site 665029004378 Maf-like protein; Region: Maf; pfam02545 665029004379 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 665029004380 active site 665029004381 dimer interface [polypeptide binding]; other site 665029004382 hypothetical protein; Provisional; Region: PRK11193 665029004383 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 665029004384 putative phosphate acyltransferase; Provisional; Region: PRK05331 665029004385 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 665029004386 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 665029004387 dimer interface [polypeptide binding]; other site 665029004388 active site 665029004389 CoA binding pocket [chemical binding]; other site 665029004390 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 665029004391 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 665029004392 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 665029004393 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 665029004394 NAD(P) binding site [chemical binding]; other site 665029004395 homotetramer interface [polypeptide binding]; other site 665029004396 homodimer interface [polypeptide binding]; other site 665029004397 active site 665029004398 acyl carrier protein; Provisional; Region: acpP; PRK00982 665029004399 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 665029004400 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 665029004401 dimer interface [polypeptide binding]; other site 665029004402 active site 665029004403 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 665029004404 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 665029004405 pyridoxal 5'-phosphate binding site [chemical binding]; other site 665029004406 catalytic residue [active] 665029004407 Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559 665029004408 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 665029004409 dimerization interface [polypeptide binding]; other site 665029004410 thymidylate kinase; Validated; Region: tmk; PRK00698 665029004411 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 665029004412 TMP-binding site; other site 665029004413 ATP-binding site [chemical binding]; other site 665029004414 DNA polymerase III subunit delta'; Validated; Region: PRK07993 665029004415 DNA polymerase III subunit delta'; Validated; Region: PRK08485 665029004416 DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115 665029004417 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 665029004418 active site 665029004419 PTS system glucose-specific transporter subunits IIBC; Provisional; Region: PRK11089 665029004420 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 665029004421 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 665029004422 active site turn [active] 665029004423 phosphorylation site [posttranslational modification] 665029004424 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 665029004425 nucleotide binding site/active site [active] 665029004426 HIT family signature motif; other site 665029004427 catalytic residue [active] 665029004428 Predicted periplasmic lipoprotein [General function prediction only]; Region: COG5633 665029004429 Putative periplasmic lipoprotein; Region: DUF1425; cd09030 665029004430 putative dimer interface [polypeptide binding]; other site 665029004431 Collagen-binding surface adhesin SpaP (antigen I/II family) [General function prediction only]; Region: FlgN; COG3417 665029004432 thiamine kinase; Region: ycfN_thiK; TIGR02721 665029004433 active site 665029004434 substrate binding site [chemical binding]; other site 665029004435 ATP binding site [chemical binding]; other site 665029004436 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 665029004437 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 665029004438 beta-hexosaminidase; Provisional; Region: PRK05337 665029004439 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2828 665029004440 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 665029004441 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 665029004442 hypothetical protein; Provisional; Region: PRK11280 665029004443 transcription-repair coupling factor; Provisional; Region: PRK10689 665029004444 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 665029004445 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 665029004446 ATP binding site [chemical binding]; other site 665029004447 putative Mg++ binding site [ion binding]; other site 665029004448 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 665029004449 nucleotide binding region [chemical binding]; other site 665029004450 ATP-binding site [chemical binding]; other site 665029004451 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 665029004452 putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915 665029004453 mannosyl-3-phosphoglycerate phosphatase; Reviewed; Region: PRK03669 665029004454 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 665029004455 active site 665029004456 motif I; other site 665029004457 motif II; other site 665029004458 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 665029004459 Proteolipid membrane potential modulator; Region: Pmp3; pfam01679 665029004460 colanic acid capsular biosynthesis activation protein A; Provisional; Region: rcsA; PRK15411 665029004461 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 665029004462 DNA binding residues [nucleotide binding] 665029004463 dimerization interface [polypeptide binding]; other site 665029004464 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 665029004465 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 665029004466 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 665029004467 flagellar biosynthesis protein FliO; Provisional; Region: PRK11486 665029004468 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 665029004469 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 665029004470 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 665029004471 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07021 665029004472 Flagellar hook-length control protein FliK; Region: Flg_hook; cl17777 665029004473 Flagellar hook-length control protein [Cell motility and secretion]; Region: FliK; COG3144 665029004474 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689 665029004475 Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882 665029004476 flagellum-specific ATP synthase; Validated; Region: fliI; PRK07960 665029004477 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 665029004478 Walker A motif/ATP binding site; other site 665029004479 Walker B motif; other site 665029004480 flagellar assembly protein H; Validated; Region: fliH; PRK05687 665029004481 Flagellar assembly protein FliH; Region: FliH; pfam02108 665029004482 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 665029004483 FliG C-terminal domain; Region: FliG_C; pfam01706 665029004484 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 665029004485 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514 665029004486 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 665029004487 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00253 665029004488 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 665029004489 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 665029004490 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 665029004491 active site 665029004492 phosphorylation site [posttranslational modification] 665029004493 intermolecular recognition site; other site 665029004494 dimerization interface [polypeptide binding]; other site 665029004495 Phage antitermination protein Q; Region: Phage_antitermQ; pfam06530 665029004496 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 665029004497 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 665029004498 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 665029004499 metal binding site [ion binding]; metal-binding site 665029004500 active site 665029004501 I-site; other site 665029004502 outer membrane-specific lipoprotein transporter subunit LolC; Provisional; Region: PRK10814 665029004503 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 665029004504 FtsX-like permease family; Region: FtsX; pfam02687 665029004505 lipoprotein transporter ATP-binding subunit; Provisional; Region: lolD; PRK11629 665029004506 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 665029004507 Walker A/P-loop; other site 665029004508 ATP binding site [chemical binding]; other site 665029004509 Q-loop/lid; other site 665029004510 ABC transporter signature motif; other site 665029004511 Walker B; other site 665029004512 D-loop; other site 665029004513 H-loop/switch region; other site 665029004514 outer membrane-specific lipoprotein transporter subunit LolE; Provisional; Region: PRK11146 665029004515 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 665029004516 FtsX-like permease family; Region: FtsX; pfam02687 665029004517 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 665029004518 NAD-dependent deacetylase; Provisional; Region: PRK00481 665029004519 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 665029004520 NAD+ binding site [chemical binding]; other site 665029004521 substrate binding site [chemical binding]; other site 665029004522 Zn binding site [ion binding]; other site 665029004523 benzoate transporter; Region: benE; TIGR00843 665029004524 Benzoate membrane transport protein; Region: BenE; pfam03594 665029004525 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 665029004526 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 665029004527 non-specific DNA binding site [nucleotide binding]; other site 665029004528 salt bridge; other site 665029004529 sequence-specific DNA binding site [nucleotide binding]; other site 665029004530 Cupin domain; Region: Cupin_2; pfam07883 665029004531 Uncharacterized conserved protein [Function unknown]; Region: COG2850 665029004532 Cupin-like domain; Region: Cupin_8; pfam13621 665029004533 sensor protein PhoQ; Provisional; Region: PRK10815 665029004534 PhoQ Sensor; Region: PhoQ_Sensor; pfam08918 665029004535 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 665029004536 dimer interface [polypeptide binding]; other site 665029004537 phosphorylation site [posttranslational modification] 665029004538 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 665029004539 ATP binding site [chemical binding]; other site 665029004540 Mg2+ binding site [ion binding]; other site 665029004541 G-X-G motif; other site 665029004542 DNA-binding transcriptional regulator PhoP; Provisional; Region: PRK10816 665029004543 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 665029004544 active site 665029004545 phosphorylation site [posttranslational modification] 665029004546 intermolecular recognition site; other site 665029004547 dimerization interface [polypeptide binding]; other site 665029004548 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 665029004549 DNA binding site [nucleotide binding] 665029004550 adenylosuccinate lyase; Provisional; Region: PRK09285 665029004551 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 665029004552 tetramer interface [polypeptide binding]; other site 665029004553 active site 665029004554 putative lysogenization regulator; Reviewed; Region: PRK00218 665029004555 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 665029004556 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Region: trmU; TIGR00420 665029004557 Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675 665029004558 nudix motif; other site 665029004559 23S rRNA pseudouridine synthase E; Provisional; Region: PRK11394 665029004560 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 665029004561 active site 665029004562 isocitrate dehydrogenase; Validated; Region: PRK07362 665029004563 isocitrate dehydrogenase; Reviewed; Region: PRK07006 665029004564 ADP-heptose:LPS heptosyl transferase I; Provisional; Region: PRK10964; cl15782 665029004565 Mig-14; Region: Mig-14; pfam07395 665029004566 Protein of unknown function (DUF754); Region: DUF754; pfam05449 665029004567 DinI-like family; Region: DinI; cl11630 665029004568 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 665029004569 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 665029004570 dimer interface [polypeptide binding]; other site 665029004571 catalytic triad [active] 665029004572 lytic murein endotransglycosylase E; Provisional; Region: emtA; PRK15470 665029004573 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 665029004574 N-acetyl-D-glucosamine binding site [chemical binding]; other site 665029004575 catalytic residue [active] 665029004576 hypothetical protein; Provisional; Region: PRK10457 665029004577 Trehalase; Region: Trehalase; cl17346 665029004578 Neutral trehalase [Carbohydrate transport and metabolism]; Region: TreA; COG1626 665029004579 N-acetyl-gamma-glutamyl-phosphate reductase; Provisional; Region: PRK11863 665029004580 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 665029004581 Protein of unknown function (DUF3142); Region: DUF3142; pfam11340 665029004582 Protein of unknown function (DUF3142); Region: DUF3142; pfam11340 665029004583 fumarate hydratase; Provisional; Region: PRK15389 665029004584 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 665029004585 Fumarase C-terminus; Region: Fumerase_C; pfam05683 665029004586 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 665029004587 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 665029004588 transmembrane helices; other site 665029004589 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 665029004590 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 665029004591 putative active site [active] 665029004592 putative FMN binding site [chemical binding]; other site 665029004593 putative substrate binding site [chemical binding]; other site 665029004594 putative catalytic residue [active] 665029004595 FMN-binding domain; Region: FMN_bind; cl01081 665029004596 fumarate reductase flavoprotein subunit; Validated; Region: PRK06481 665029004597 L-aspartate oxidase; Provisional; Region: PRK06175 665029004598 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 665029004599 ApbE family; Region: ApbE; pfam02424 665029004600 DNA-binding transcriptional activator DcuR; Provisional; Region: PRK10430 665029004601 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 665029004602 active site 665029004603 phosphorylation site [posttranslational modification] 665029004604 intermolecular recognition site; other site 665029004605 dimerization interface [polypeptide binding]; other site 665029004606 sensory histidine kinase DcuS; Provisional; Region: PRK11086 665029004607 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 665029004608 ATP binding site [chemical binding]; other site 665029004609 Mg2+ binding site [ion binding]; other site 665029004610 G-X-G motif; other site 665029004611 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 665029004612 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 665029004613 Biofilm development protein YmgB/AriR; Region: YmgB; pfam10798 665029004614 DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710 665029004615 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 665029004616 DNA binding site [nucleotide binding] 665029004617 Bacterial type III secretion apparatus protein (OrgA_MxiK); Region: OrgA_MxiK; cl09716 665029004618 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 665029004619 type III secretion system needle complex protein PrgJ; Provisional; Region: PRK15325 665029004620 Type III secretion system protein PrgH-EprH (PrgH); Region: PrgH; pfam09480 665029004621 type III secretion system needle complex protein PrgH; Provisional; Region: PRK15327; cl12363 665029004622 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 665029004623 type III secretion outer membrane pore, YscC/HrcC family; Region: type_III_yscC; TIGR02516 665029004624 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 665029004625 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 665029004626 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 665029004627 HrpJ-like domain; Region: HrpJ; pfam07201 665029004628 type III secretion system regulator InvE; Provisional; Region: PRK15338 665029004629 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; cl07980 665029004630 type III secretion system protein InvA; Provisional; Region: PRK15337 665029004631 Invasion protein B family; Region: Invas_SpaK; cl04129 665029004632 ATP synthase SpaL; Validated; Region: PRK08149 665029004633 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 665029004634 Walker A motif; other site 665029004635 ATP binding site [chemical binding]; other site 665029004636 Walker B motif; other site 665029004637 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 665029004638 type III secretion system protein SpaP; Provisional; Region: spaP; PRK12796 665029004639 Type III secretory pathway, component EscS [Intracellular trafficking and secretion]; Region: EscS; COG4794 665029004640 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 665029004641 type III secretion system protein SpaS; Validated; Region: PRK08156 665029004642 chaperone protein SicA; Provisional; Region: PRK15331 665029004643 Tetratricopeptide repeat; Region: TPR_3; pfam07720 665029004644 Tetratricopeptide repeat; Region: TPR_3; pfam07720 665029004645 Secretion system effector C (SseC) like family; Region: SseC; pfam04888 665029004646 Protein of unknown function (DUF1120); Region: DUF1120; cl05856 665029004647 Invasion plasmid antigen IpaD; Region: IpaD; cl05827 665029004648 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 665029004649 GTP-binding protein YchF; Reviewed; Region: PRK09601 665029004650 YchF GTPase; Region: YchF; cd01900 665029004651 G1 box; other site 665029004652 GTP/Mg2+ binding site [chemical binding]; other site 665029004653 Switch I region; other site 665029004654 G2 box; other site 665029004655 Switch II region; other site 665029004656 G3 box; other site 665029004657 G4 box; other site 665029004658 G5 box; other site 665029004659 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 665029004660 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 665029004661 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 665029004662 Sulfate transporter family; Region: Sulfate_transp; pfam00916 665029004663 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 665029004664 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 665029004665 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290 665029004666 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 665029004667 putative active site [active] 665029004668 catalytic residue [active] 665029004669 hypothetical protein; Provisional; Region: PRK10692 665029004670 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 665029004671 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 665029004672 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 665029004673 active site 665029004674 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 665029004675 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 665029004676 outer membrane lipoprotein LolB; Provisional; Region: lolB; PRK00022 665029004677 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 665029004678 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 665029004679 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 665029004680 tRNA; other site 665029004681 putative tRNA binding site [nucleotide binding]; other site 665029004682 putative NADP binding site [chemical binding]; other site 665029004683 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 665029004684 peptide chain release factor 1; Validated; Region: prfA; PRK00591 665029004685 This domain is found in peptide chain release factors; Region: PCRF; smart00937 665029004686 RF-1 domain; Region: RF-1; pfam00472 665029004687 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 665029004688 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 665029004689 S-adenosylmethionine binding site [chemical binding]; other site 665029004690 Invasion gene expression up-regulator, SirB; Region: SirB; cl01184 665029004691 hypothetical protein; Provisional; Region: PRK10941 665029004692 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 665029004693 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 665029004694 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 665029004695 META domain; Region: META; cl01245 665029004696 calcium/sodium:proton antiporter; Provisional; Region: PRK10599 665029004697 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 665029004698 D-fructose-responsive transcription factor; Region: fruct_sucro_rep; TIGR02417 665029004699 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 665029004700 DNA binding site [nucleotide binding] 665029004701 domain linker motif; other site 665029004702 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 665029004703 dimerization interface [polypeptide binding]; other site 665029004704 ligand binding site [chemical binding]; other site 665029004705 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 665029004706 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 665029004707 substrate binding [chemical binding]; other site 665029004708 active site 665029004709 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 665029004710 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 665029004711 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 665029004712 active site turn [active] 665029004713 phosphorylation site [posttranslational modification] 665029004714 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 665029004715 Maltoporin periplasmic N-terminal extension; Region: Sugarporin_N; pfam11471 665029004716 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 665029004717 trimer interface; other site 665029004718 sugar binding site [chemical binding]; other site 665029004719 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 665029004720 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 665029004721 putative substrate binding site [chemical binding]; other site 665029004722 putative ATP binding site [chemical binding]; other site 665029004723 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 665029004724 putative active site pocket [active] 665029004725 dimerization interface [polypeptide binding]; other site 665029004726 putative catalytic residue [active] 665029004727 type VI secretion system FHA domain protein; Region: VI_FHA; TIGR03354 665029004728 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 665029004729 phosphopeptide binding site; other site 665029004730 Uncharacterized protein conserved in bacteria (DUF2094); Region: DUF2094; pfam09867 665029004731 ImcF-related N-terminal domain; Region: ImcF-related_N; pfam14331 665029004732 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 665029004733 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850 665029004734 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 665029004735 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 665029004736 ligand binding site [chemical binding]; other site 665029004737 putative invasin; Provisional; Region: PRK10177 665029004738 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 665029004739 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 665029004740 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 665029004741 trimer interface [polypeptide binding]; other site 665029004742 eyelet of channel; other site 665029004743 bifunctional succinylornithine transaminase/acetylornithine transaminase; Provisional; Region: PRK12381 665029004744 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 665029004745 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 665029004746 catalytic residue [active] 665029004747 arginine succinyltransferase; Provisional; Region: PRK10456 665029004748 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 665029004749 succinylglutamic semialdehyde dehydrogenase; Reviewed; Region: astD; PRK09457 665029004750 N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095 665029004751 NAD(P) binding site [chemical binding]; other site 665029004752 catalytic residues [active] 665029004753 succinylarginine dihydrolase; Provisional; Region: PRK13281 665029004754 succinylglutamate desuccinylase; Provisional; Region: PRK05324 665029004755 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 665029004756 active site 665029004757 Zn binding site [ion binding]; other site 665029004758 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 665029004759 dimer interface [polypeptide binding]; other site 665029004760 nucleotide excision repair endonuclease; Provisional; Region: PRK10545 665029004761 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 665029004762 GIY-YIG motif/motif A; other site 665029004763 active site 665029004764 catalytic site [active] 665029004765 putative DNA binding site [nucleotide binding]; other site 665029004766 metal binding site [ion binding]; metal-binding site 665029004767 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 665029004768 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 665029004769 homodimer interface [polypeptide binding]; other site 665029004770 NAD binding pocket [chemical binding]; other site 665029004771 ATP binding pocket [chemical binding]; other site 665029004772 Mg binding site [ion binding]; other site 665029004773 active-site loop [active] 665029004774 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 665029004775 DNA-binding transcriptional activator OsmE; Provisional; Region: PRK11251 665029004776 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 665029004777 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 665029004778 inner membrane protein; Provisional; Region: PRK11648 665029004779 2-deoxyglucose-6-phosphatase; Provisional; Region: PRK10826 665029004780 YniB-like protein; Region: YniB; pfam14002 665029004781 Phosphotransferase enzyme family; Region: APH; pfam01636 665029004782 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 665029004783 active site 665029004784 ATP binding site [chemical binding]; other site 665029004785 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 665029004786 Protein of unknown function (DUF2622); Region: DUF2622; pfam11080 665029004787 Protein of unknown function, DUF481; Region: DUF481; cl01213 665029004788 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 665029004789 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 665029004790 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 665029004791 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 665029004792 active site 665029004793 dimer interface [polypeptide binding]; other site 665029004794 motif 1; other site 665029004795 motif 2; other site 665029004796 motif 3; other site 665029004797 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 665029004798 anticodon binding site; other site 665029004799 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 665029004800 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 665029004801 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 665029004802 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 665029004803 23S rRNA binding site [nucleotide binding]; other site 665029004804 L21 binding site [polypeptide binding]; other site 665029004805 L13 binding site [polypeptide binding]; other site 665029004806 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 665029004807 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 665029004808 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 665029004809 dimer interface [polypeptide binding]; other site 665029004810 motif 1; other site 665029004811 active site 665029004812 motif 2; other site 665029004813 motif 3; other site 665029004814 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 665029004815 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 665029004816 putative tRNA-binding site [nucleotide binding]; other site 665029004817 B3/4 domain; Region: B3_4; pfam03483 665029004818 tRNA synthetase B5 domain; Region: B5; smart00874 665029004819 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 665029004820 dimer interface [polypeptide binding]; other site 665029004821 motif 1; other site 665029004822 motif 3; other site 665029004823 motif 2; other site 665029004824 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 665029004825 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 665029004826 IHF dimer interface [polypeptide binding]; other site 665029004827 IHF - DNA interface [nucleotide binding]; other site 665029004828 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 665029004829 catalytic residues [active] 665029004830 dimer interface [polypeptide binding]; other site 665029004831 outer membrane lipoprotein; Provisional; Region: spr; PRK10838 665029004832 NlpC/P60 family; Region: NLPC_P60; pfam00877 665029004833 potential protein location (hypothetical protein predicted by Glimmer/Critica) that overlaps protein (hypothetical protein predicted by Glimmer/Critica) 665029004834 potential protein location (hypothetical protein predicted by Glimmer/Critica) that overlaps protein (hypothetical protein predicted by Glimmer/Critica) 665029004835 Uncharacterized conserved protein [Function unknown]; Region: COG0397 665029004836 hypothetical protein; Validated; Region: PRK00029 665029004837 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 665029004838 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 665029004839 Walker A/P-loop; other site 665029004840 ATP binding site [chemical binding]; other site 665029004841 Q-loop/lid; other site 665029004842 ABC transporter signature motif; other site 665029004843 Walker B; other site 665029004844 D-loop; other site 665029004845 H-loop/switch region; other site 665029004846 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 665029004847 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 665029004848 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 665029004849 ABC-ATPase subunit interface; other site 665029004850 dimer interface [polypeptide binding]; other site 665029004851 putative PBP binding regions; other site 665029004852 Hemin binding protein HutB. These proteins have been shown to function as initial receptors in ABC transport of hemin and hemoproteins in many eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a...; Region: HutB; cd01149 665029004853 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 665029004854 putative hemin binding site; other site 665029004855 Putative heme degradation protein [Inorganic ion transport and metabolism]; Region: HemS; COG3720 665029004856 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 665029004857 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 665029004858 potential protein location (hypothetical protein predicted by Glimmer/Critica) that overlaps protein (hypothetical protein predicted by Glimmer/Critica) 665029004859 potential protein location (hypothetical protein predicted by Glimmer/Critica) that overlaps protein (hypothetical protein predicted by Glimmer/Critica) 665029004860 PEP synthetase regulatory protein; Provisional; Region: PRK05339 665029004861 phosphoenolpyruvate synthase; Validated; Region: PRK06464 665029004862 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 665029004863 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 665029004864 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 665029004865 putative inner membrane protein; Provisional; Region: PRK10983 665029004866 Domain of unknown function DUF20; Region: UPF0118; pfam01594 665029004867 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 665029004868 FAD binding domain; Region: FAD_binding_4; pfam01565 665029004869 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 665029004870 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 665029004871 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 665029004872 putative ABC transporter; Region: ycf24; CHL00085 665029004873 cysteine desulfurase ATPase component; Reviewed; Region: sufC; PRK09580 665029004874 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 665029004875 Walker A/P-loop; other site 665029004876 ATP binding site [chemical binding]; other site 665029004877 Q-loop/lid; other site 665029004878 ABC transporter signature motif; other site 665029004879 Walker B; other site 665029004880 D-loop; other site 665029004881 H-loop/switch region; other site 665029004882 cysteine desulfurase activator complex subunit SufD; Provisional; Region: PRK10948 665029004883 FeS assembly protein SufD; Region: sufD; TIGR01981 665029004884 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 665029004885 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 665029004886 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 665029004887 catalytic residue [active] 665029004888 cysteine desufuration protein SufE; Provisional; Region: PRK09296 665029004889 murein lipoprotein; Provisional; Region: PRK15396 665029004890 pyruvate kinase; Provisional; Region: PRK09206 665029004891 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 665029004892 domain interfaces; other site 665029004893 active site 665029004894 potential protein location (hypothetical protein predicted by Glimmer/Critica [Erwinia amylovora]) that overlaps RNA (tRNA-V) 665029004895 multidrug efflux protein; Reviewed; Region: PRK01766 665029004896 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 665029004897 cation binding site [ion binding]; other site 665029004898 riboflavin synthase subunit alpha; Provisional; Region: PRK13020 665029004899 Lumazine binding domain; Region: Lum_binding; pfam00677 665029004900 Lumazine binding domain; Region: Lum_binding; pfam00677 665029004901 cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705 665029004902 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 665029004903 S-adenosylmethionine binding site [chemical binding]; other site 665029004904 putative transporter; Provisional; Region: PRK11043 665029004905 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 665029004906 putative substrate translocation pore; other site 665029004907 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 665029004908 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 665029004909 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 665029004910 dimerization interface [polypeptide binding]; other site 665029004911 DNA-binding transcriptional repressor PurR; Provisional; Region: PRK10703 665029004912 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 665029004913 DNA binding site [nucleotide binding] 665029004914 domain linker motif; other site 665029004915 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 665029004916 dimerization interface [polypeptide binding]; other site 665029004917 ligand binding site [chemical binding]; other site 665029004918 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 665029004919 NlpC/P60 family; Region: NLPC_P60; pfam00877 665029004920 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 665029004921 putative GSH binding site [chemical binding]; other site 665029004922 catalytic residues [active] 665029004923 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 665029004924 DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134 665029004925 dimer interface [polypeptide binding]; other site 665029004926 catalytic site [active] 665029004927 putative active site [active] 665029004928 putative substrate binding site [chemical binding]; other site 665029004929 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 665029004930 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 665029004931 dimer interface [polypeptide binding]; other site 665029004932 active site 665029004933 metal binding site [ion binding]; metal-binding site 665029004934 glutathione binding site [chemical binding]; other site 665029004935 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 665029004936 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 665029004937 FMN binding site [chemical binding]; other site 665029004938 active site 665029004939 substrate binding site [chemical binding]; other site 665029004940 catalytic residue [active] 665029004941 putative metal dependent hydrolase; Provisional; Region: PRK11598 665029004942 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 665029004943 Sulfatase; Region: Sulfatase; pfam00884 665029004944 Protein of unknown function (DUF1289); Region: DUF1289; cl01304 665029004945 Apolipoprotein A1/A4/E domain; Region: Apolipoprotein; pfam01442 665029004946 transcriptional regulator SlyA; Provisional; Region: PRK03573 665029004947 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 665029004948 Outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: SlyB; COG3133 665029004949 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 665029004950 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 665029004951 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 665029004952 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 665029004953 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 665029004954 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 665029004955 active site 665029004956 HIGH motif; other site 665029004957 dimer interface [polypeptide binding]; other site 665029004958 KMSKS motif; other site 665029004959 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 665029004960 RNA binding surface [nucleotide binding]; other site 665029004961 potential frameshift: common BLAST hit: gi|259908528|ref|YP_002648884.1| Pyridoxamine kinase 665029004962 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 665029004963 dimer interface [polypeptide binding]; other site 665029004964 pyridoxal binding site [chemical binding]; other site 665029004965 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 665029004966 ATP binding site [chemical binding]; other site 665029004967 substrate binding site [chemical binding]; other site 665029004968 glutathionine S-transferase; Provisional; Region: PRK10542 665029004969 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 665029004970 C-terminal domain interface [polypeptide binding]; other site 665029004971 GSH binding site (G-site) [chemical binding]; other site 665029004972 dimer interface [polypeptide binding]; other site 665029004973 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 665029004974 dimer interface [polypeptide binding]; other site 665029004975 N-terminal domain interface [polypeptide binding]; other site 665029004976 substrate binding pocket (H-site) [chemical binding]; other site 665029004977 dipeptide/tripeptide permease B; Provisional; Region: PRK10207 665029004978 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 665029004979 putative substrate translocation pore; other site 665029004980 POT family; Region: PTR2; pfam00854 665029004981 transcriptional regulator BetI; Validated; Region: PRK00767 665029004982 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 665029004983 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 665029004984 betaine aldehyde dehydrogenase; Provisional; Region: PRK13252 665029004985 NAD+-dependent 4-trimethylaminobutyraldehyde dehydrogenase, ALDH family 9A1; Region: ALDH_F9_TMBADH; cd07090 665029004986 tetrameric interface [polypeptide binding]; other site 665029004987 NAD binding site [chemical binding]; other site 665029004988 catalytic residues [active] 665029004989 choline dehydrogenase; Validated; Region: PRK02106 665029004990 lycopene cyclase; Region: lycopene_cycl; TIGR01789 665029004991 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 665029004992 endonuclease III; Provisional; Region: PRK10702 665029004993 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 665029004994 minor groove reading motif; other site 665029004995 helix-hairpin-helix signature motif; other site 665029004996 substrate binding pocket [chemical binding]; other site 665029004997 active site 665029004998 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 665029004999 electron transport complex RsxE subunit; Provisional; Region: PRK12405 665029005000 electron transport complex protein RnfG; Validated; Region: PRK01908 665029005001 electron transport complex protein RnfD; Reviewed; Region: rnfD; PRK00816 665029005002 electron transport complex, RnfABCDGE type, C subunit; Region: rnfC; TIGR01945 665029005003 SLBB domain; Region: SLBB; pfam10531 665029005004 electron transport complex protein RnfB; Provisional; Region: PRK05113 665029005005 Putative Fe-S cluster; Region: FeS; cl17515 665029005006 4Fe-4S binding domain; Region: Fer4; cl02805 665029005007 electron transport complex protein RsxA; Provisional; Region: PRK05151 665029005008 Protein of unknown function (DUF2569); Region: DUF2569; pfam10754 665029005009 L-arabinose isomerase; Provisional; Region: PRK02929 665029005010 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 665029005011 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 665029005012 trimer interface [polypeptide binding]; other site 665029005013 putative substrate binding site [chemical binding]; other site 665029005014 putative metal binding site [ion binding]; other site 665029005015 ribulokinase; Provisional; Region: PRK04123 665029005016 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 665029005017 N- and C-terminal domain interface [polypeptide binding]; other site 665029005018 active site 665029005019 MgATP binding site [chemical binding]; other site 665029005020 catalytic site [active] 665029005021 metal binding site [ion binding]; metal-binding site 665029005022 carbohydrate binding site [chemical binding]; other site 665029005023 homodimer interface [polypeptide binding]; other site 665029005024 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 665029005025 Periplasmic L-arabinose-binding protein (ABP), a member of a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein superfamily; Region: PBP1_arabinose_binding; cd01540 665029005026 ligand binding site [chemical binding]; other site 665029005027 L-arabinose transporter ATP-binding protein; Provisional; Region: araG; PRK11288 665029005028 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 665029005029 Walker A/P-loop; other site 665029005030 ATP binding site [chemical binding]; other site 665029005031 Q-loop/lid; other site 665029005032 ABC transporter signature motif; other site 665029005033 Walker B; other site 665029005034 D-loop; other site 665029005035 H-loop/switch region; other site 665029005036 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 665029005037 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 665029005038 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 665029005039 TM-ABC transporter signature motif; other site 665029005040 DNA-binding transcriptional regulator AraC; Provisional; Region: PRK10572 665029005041 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 665029005042 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 665029005043 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 665029005044 putative oxidoreductase; Provisional; Region: PRK11579 665029005045 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 665029005046 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 665029005047 adenosine deaminase; Provisional; Region: PRK09358 665029005048 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 665029005049 active site 665029005050 Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097 665029005051 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339 665029005052 fumarate hydratase; Reviewed; Region: fumC; PRK00485 665029005053 Class II fumarases; Region: Fumarase_classII; cd01362 665029005054 active site 665029005055 tetramer interface [polypeptide binding]; other site 665029005056 DNA replication terminus site-binding protein; Provisional; Region: PRK02951 665029005057 Protein of unknown function (DUF1460); Region: DUF1460; pfam07313 665029005058 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 665029005059 Major Facilitator Superfamily; Region: MFS_1; pfam07690 665029005060 putative substrate translocation pore; other site 665029005061 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 665029005062 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 665029005063 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 665029005064 dimerization interface [polypeptide binding]; other site 665029005065 substrate binding pocket [chemical binding]; other site 665029005066 MarR family; Region: MarR_2; cl17246 665029005067 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 665029005068 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 665029005069 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 665029005070 AAA domain; Region: AAA_26; pfam13500 665029005071 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 665029005072 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 665029005073 putative substrate translocation pore; other site 665029005074 Protein of unknown function (DUF1161); Region: DUF1161; pfam06649 665029005075 hypothetical protein; Provisional; Region: PRK13659 665029005076 malonic semialdehyde reductase; Provisional; Region: PRK10538 665029005077 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 665029005078 putative NAD(P) binding site [chemical binding]; other site 665029005079 homodimer interface [polypeptide binding]; other site 665029005080 homotetramer interface [polypeptide binding]; other site 665029005081 active site 665029005082 guanine deaminase; Provisional; Region: PRK09228 665029005083 Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303 665029005084 active site 665029005085 dipeptidyl carboxypeptidase II; Provisional; Region: PRK10280 665029005086 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 665029005087 active site 665029005088 Zn binding site [ion binding]; other site 665029005089 hypothetical protein; Provisional; Region: PRK06847 665029005090 hypothetical protein; Provisional; Region: PRK07236 665029005091 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 665029005092 Predicted membrane protein [Function unknown]; Region: COG2707 665029005093 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 665029005094 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 665029005095 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 665029005096 NAD(P) binding site [chemical binding]; other site 665029005097 trans-2-enoyl-CoA reductase; Provisional; Region: PRK13656 665029005098 NAD(P)H binding domain of trans-2-enoyl-CoA reductase; Region: Eno-Rase_NADH_b; pfam12242 665029005099 Trans-2-enoyl-CoA reductase catalytic region; Region: Enoyl_reductase; pfam12241 665029005100 Enoyl reductase FAD binding domain; Region: Eno-Rase_FAD_bd; pfam07055 665029005101 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 665029005102 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 665029005103 N-terminal plug; other site 665029005104 ligand-binding site [chemical binding]; other site 665029005105 Rdx family; Region: Rdx; cl01407 665029005106 Protein of unknown function (DUF1345); Region: DUF1345; pfam07077 665029005107 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 665029005108 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 665029005109 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 665029005110 Protein of unknown function (DUF3313); Region: DUF3313; pfam11769 665029005111 Catalytic domain of Bacillus cereus phosphatidylinositol-specific phospholipases C and similar proteins; Region: PI-PLCc_BcPLC_like; cd08586 665029005112 active site 665029005113 catalytic site [active] 665029005114 putative metal binding site [ion binding]; other site 665029005115 lipoprotein; Provisional; Region: PRK10540 665029005116 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 665029005117 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 665029005118 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 665029005119 Coenzyme A binding pocket [chemical binding]; other site 665029005120 HAD superfamily, subfamily IIIB (Acid phosphatase); Region: Acid_phosphat_B; cl17236 665029005121 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 665029005122 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 665029005123 tetramer interface [polypeptide binding]; other site 665029005124 heme binding pocket [chemical binding]; other site 665029005125 NADPH binding site [chemical binding]; other site 665029005126 Antitoxin of toxin-antitoxin stability system N-terminal; Region: RelB_N; pfam12910 665029005127 Fic/DOC family; Region: Fic; cl00960 665029005128 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 665029005129 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 665029005130 dimer interface [polypeptide binding]; other site 665029005131 putative CheW interface [polypeptide binding]; other site 665029005132 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 665029005133 active site clefts [active] 665029005134 zinc binding site [ion binding]; other site 665029005135 dimer interface [polypeptide binding]; other site 665029005136 Domain of unknown function (DUF4385); Region: DUF4385; pfam14328 665029005137 malate:quinone oxidoreductase; Validated; Region: PRK05257 665029005138 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 665029005139 Virulence factor SrfB; Region: SrfB; pfam07520 665029005140 Putative bacterial virulence factor; Region: Virul_Fac; pfam10139 665029005141 hypothetical protein; Provisional; Region: PRK07190 665029005142 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 665029005143 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 665029005144 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 665029005145 substrate binding pocket [chemical binding]; other site 665029005146 active site 665029005147 iron coordination sites [ion binding]; other site 665029005148 Pyoverdine/dityrosine biosynthesis protein; Region: DIT1_PvcA; pfam05141 665029005149 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it thus inhibiting its potentially lethal RNase activity inside the cell; Region: Barstar; cd05142 665029005150 RNAase interaction site [polypeptide binding]; other site 665029005151 microbial_RNases. Ribonucleases (RNAses) cleave phosphodiester bonds in RNA and are essential for both non-specific RNA degradation and for numerous forms of RNA processing. The alignment contains fungal RNases (U2, T1, F1, Th, Pb, N1, and Ms) and...; Region: microbial_RNases; cl00212 665029005152 active site 665029005153 Domain of unknown function DUF20; Region: UPF0118; pfam01594 665029005154 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 665029005155 Rrf2 family protein; Region: rrf2_super; TIGR00738 665029005156 Transcriptional regulator; Region: Rrf2; pfam02082 665029005157 Transcriptional regulator; Region: Rrf2; cl17282 665029005158 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 665029005159 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 665029005160 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 665029005161 glutaminase; Provisional; Region: PRK00971 665029005162 putative arabinose transporter; Provisional; Region: PRK03545 665029005163 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 665029005164 putative substrate translocation pore; other site 665029005165 Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163 665029005166 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 665029005167 Flavin binding site [chemical binding]; other site 665029005168 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 665029005169 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 665029005170 active site 665029005171 non-prolyl cis peptide bond; other site 665029005172 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 665029005173 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 665029005174 dimethyl sulfone monooxygenase SfnG; Region: LLM_DMSO2_sfnG; TIGR04021 665029005175 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 665029005176 active site 665029005177 dimer interface [polypeptide binding]; other site 665029005178 non-prolyl cis peptide bond; other site 665029005179 insertion regions; other site 665029005180 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 665029005181 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 665029005182 active site 665029005183 dimer interface [polypeptide binding]; other site 665029005184 non-prolyl cis peptide bond; other site 665029005185 insertion regions; other site 665029005186 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cd00368 665029005187 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 665029005188 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 665029005189 Walker A motif; other site 665029005190 ATP binding site [chemical binding]; other site 665029005191 Walker B motif; other site 665029005192 arginine finger; other site 665029005193 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 665029005194 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 665029005195 substrate binding pocket [chemical binding]; other site 665029005196 membrane-bound complex binding site; other site 665029005197 hinge residues; other site 665029005198 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 665029005199 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 665029005200 peptide binding site [polypeptide binding]; other site 665029005201 Protein of unknown function, DUF594; Region: DUF594; pfam04578 665029005202 Di- and tripeptidases [Amino acid transport and metabolism]; Region: PepD; COG2195 665029005203 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 665029005204 metal binding site [ion binding]; metal-binding site 665029005205 dimer interface [polypeptide binding]; other site 665029005206 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 665029005207 dimerization interface [polypeptide binding]; other site 665029005208 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 665029005209 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 665029005210 dimer interface [polypeptide binding]; other site 665029005211 putative CheW interface [polypeptide binding]; other site 665029005212 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 665029005213 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 665029005214 substrate binding pocket [chemical binding]; other site 665029005215 catalytic triad [active] 665029005216 benzoate transport; Region: 2A0115; TIGR00895 665029005217 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 665029005218 putative substrate translocation pore; other site 665029005219 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 665029005220 putative substrate translocation pore; other site 665029005221 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 665029005222 Acyltransferase family; Region: Acyl_transf_3; pfam01757 665029005223 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 665029005224 Smr domain; Region: Smr; pfam01713 665029005225 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 665029005226 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 665029005227 ligand binding site [chemical binding]; other site 665029005228 flexible hinge region; other site 665029005229 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 665029005230 putative switch regulator; other site 665029005231 non-specific DNA interactions [nucleotide binding]; other site 665029005232 DNA binding site [nucleotide binding] 665029005233 sequence specific DNA binding site [nucleotide binding]; other site 665029005234 putative cAMP binding site [chemical binding]; other site 665029005235 universal stress protein UspE; Provisional; Region: PRK11175 665029005236 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 665029005237 Ligand Binding Site [chemical binding]; other site 665029005238 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 665029005239 Ligand Binding Site [chemical binding]; other site 665029005240 Protein of unknown function (DUF2946); Region: DUF2946; pfam11162 665029005241 TonB-dependent copper receptor; Region: TonB-copper; TIGR01778 665029005242 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 665029005243 N-terminal plug; other site 665029005244 ligand-binding site [chemical binding]; other site 665029005245 Protein of unknown function (DUF2534); Region: DUF2534; pfam10749 665029005246 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 665029005247 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 665029005248 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 665029005249 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 665029005250 DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701 665029005251 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 665029005252 active site 665029005253 phosphorylation site [posttranslational modification] 665029005254 intermolecular recognition site; other site 665029005255 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 665029005256 DNA binding site [nucleotide binding] 665029005257 YcfA-like protein; Region: YcfA; pfam07927 665029005258 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 665029005259 Acyltransferase family; Region: Acyl_transf_3; pfam01757 665029005260 B12 binding domain; Region: B12-binding_2; cl03653 665029005261 Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675 665029005262 Protein of unknown function (DUF2612); Region: DUF2612; pfam11041 665029005263 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 665029005264 phiCTX phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various phage and bacterial integrases, including those similar to phage integrases: Bordetella and...; Region: INT_phiCTX_C; cd01191 665029005265 Int/Topo IB signature motif; other site 665029005266 sensor protein RstB; Provisional; Region: PRK10604 665029005267 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 665029005268 dimerization interface [polypeptide binding]; other site 665029005269 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 665029005270 dimer interface [polypeptide binding]; other site 665029005271 phosphorylation site [posttranslational modification] 665029005272 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 665029005273 ATP binding site [chemical binding]; other site 665029005274 Mg2+ binding site [ion binding]; other site 665029005275 G-X-G motif; other site 665029005276 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 665029005277 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 665029005278 active site 665029005279 Zn binding site [ion binding]; other site 665029005280 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 665029005281 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 665029005282 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 665029005283 amidase catalytic site [active] 665029005284 Zn binding residues [ion binding]; other site 665029005285 substrate binding site [chemical binding]; other site 665029005286 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 665029005287 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 665029005288 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 665029005289 ATP binding site [chemical binding]; other site 665029005290 putative Mg++ binding site [ion binding]; other site 665029005291 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 665029005292 nucleotide binding region [chemical binding]; other site 665029005293 ATP-binding site [chemical binding]; other site 665029005294 Helicase associated domain (HA2); Region: HA2; pfam04408 665029005295 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 665029005296 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 665029005297 azoreductase; Reviewed; Region: PRK00170 665029005298 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 665029005299 short chain dehydrogenase; Provisional; Region: PRK09291 665029005300 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 665029005301 NAD(P) binding site [chemical binding]; other site 665029005302 active site 665029005303 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3784 665029005304 YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617 665029005305 hypothetical protein; Provisional; Region: PRK10695 665029005306 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 665029005307 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 665029005308 putative ligand binding site [chemical binding]; other site 665029005309 putative NAD binding site [chemical binding]; other site 665029005310 catalytic site [active] 665029005311 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 665029005312 Domain of unknown function (DUF333); Region: DUF333; pfam03891 665029005313 Uncharacterized conserved protein [Function unknown]; Region: COG1359 665029005314 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 665029005315 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 665029005316 ATP binding site [chemical binding]; other site 665029005317 Mg++ binding site [ion binding]; other site 665029005318 motif III; other site 665029005319 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 665029005320 nucleotide binding region [chemical binding]; other site 665029005321 ATP-binding site [chemical binding]; other site 665029005322 RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501 665029005323 putative RNA binding site [nucleotide binding]; other site 665029005324 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 665029005325 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 665029005326 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 665029005327 Ligand Binding Site [chemical binding]; other site 665029005328 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 665029005329 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 665029005330 Ca binding site [ion binding]; other site 665029005331 active site 665029005332 catalytic site [active] 665029005333 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 665029005334 Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; Region: ZntB-like_1; cd12833 665029005335 Cl binding site [ion binding]; other site 665029005336 oligomer interface [polypeptide binding]; other site 665029005337 Protein of unknown function (DUF1120); Region: DUF1120; cl05856 665029005338 putative fimbrial chaperone protein; Provisional; Region: PRK09918 665029005339 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 665029005340 putative fimbrial outer membrane usher protein; Provisional; Region: PRK15304 665029005341 PapC N-terminal domain; Region: PapC_N; pfam13954 665029005342 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 665029005343 PapC C-terminal domain; Region: PapC_C; pfam13953 665029005344 hypothetical protein; Provisional; Region: PRK15301 665029005345 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 665029005346 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 665029005347 peptide binding site [polypeptide binding]; other site 665029005348 L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129 665029005349 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 665029005350 active site 665029005351 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 665029005352 dimer interface [polypeptide binding]; other site 665029005353 catalytic triad [active] 665029005354 peroxidatic and resolving cysteines [active] 665029005355 DNA-binding transcriptional regulator TyrR; Provisional; Region: PRK10820 665029005356 N-terminal ACT domain of the TyrR protein; Region: ACT_TyrR; cd04877 665029005357 putative aromatic amino acid binding site; other site 665029005358 PAS domain; Region: PAS; smart00091 665029005359 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 665029005360 Walker A motif; other site 665029005361 ATP binding site [chemical binding]; other site 665029005362 Walker B motif; other site 665029005363 arginine finger; other site 665029005364 hypothetical protein; Provisional; Region: PRK05415 665029005365 Domain of unknown function (DUF697); Region: DUF697; cl12064 665029005366 Predicted ATPase [General function prediction only]; Region: COG3106 665029005367 peripheral inner membrane phage-shock protein; Provisional; Region: PRK10497 665029005368 DNA-binding transcriptional activator PspC; Provisional; Region: PRK10697 665029005369 phage shock protein C; Region: phageshock_pspC; TIGR02978 665029005370 phage shock protein B; Provisional; Region: pspB; PRK09458 665029005371 phage shock protein PspA; Provisional; Region: PRK10698 665029005372 phage shock protein operon transcriptional activator; Provisional; Region: pspF; PRK11608 665029005373 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 665029005374 Walker A motif; other site 665029005375 ATP binding site [chemical binding]; other site 665029005376 Walker B motif; other site 665029005377 arginine finger; other site 665029005378 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 665029005379 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 665029005380 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 665029005381 peptide binding site [polypeptide binding]; other site 665029005382 antimicrobial peptide ABC transporter permease SapB; Provisional; Region: PRK15110 665029005383 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 665029005384 dimer interface [polypeptide binding]; other site 665029005385 conserved gate region; other site 665029005386 putative PBP binding loops; other site 665029005387 ABC-ATPase subunit interface; other site 665029005388 antimicrobial peptide ABC transporter permease SapC; Provisional; Region: PRK15111 665029005389 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 665029005390 dimer interface [polypeptide binding]; other site 665029005391 conserved gate region; other site 665029005392 putative PBP binding loops; other site 665029005393 ABC-ATPase subunit interface; other site 665029005394 antimicrobial peptide ABC transporter ATP-binding protein; Provisional; Region: PRK15093 665029005395 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 665029005396 Walker A/P-loop; other site 665029005397 ATP binding site [chemical binding]; other site 665029005398 Q-loop/lid; other site 665029005399 ABC transporter signature motif; other site 665029005400 Walker B; other site 665029005401 D-loop; other site 665029005402 H-loop/switch region; other site 665029005403 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 665029005404 antimicrobial peptide ABC system ATP-binding protein SapF; Provisional; Region: PRK15112 665029005405 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 665029005406 Walker A/P-loop; other site 665029005407 ATP binding site [chemical binding]; other site 665029005408 Q-loop/lid; other site 665029005409 ABC transporter signature motif; other site 665029005410 Walker B; other site 665029005411 D-loop; other site 665029005412 H-loop/switch region; other site 665029005413 hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203 665029005414 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950; cl17731 665029005415 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 665029005416 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 665029005417 Transcriptional regulator [Transcription]; Region: LysR; COG0583 665029005418 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 665029005419 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 665029005420 dimerization interface [polypeptide binding]; other site 665029005421 PAAR motif; Region: PAAR_motif; pfam05488 665029005422 Uncharacterized conserved protein (DUF2235); Region: DUF2235; cl01480 665029005423 Protein of unknown function (DUF2931); Region: DUF2931; pfam11153 665029005424 Protein of unknown function (DUF2931); Region: DUF2931; pfam11153 665029005425 Protein of unknown function (DUF2931); Region: DUF2931; pfam11153 665029005426 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 665029005427 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 665029005428 putative molybdopterin cofactor binding site [chemical binding]; other site 665029005429 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 665029005430 putative molybdopterin cofactor binding site; other site 665029005431 exoribonuclease II; Provisional; Region: PRK05054 665029005432 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 665029005433 RNB domain; Region: RNB; pfam00773 665029005434 S1 RNA binding domain; Region: S1; pfam00575 665029005435 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 665029005436 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 665029005437 intersubunit interface [polypeptide binding]; other site 665029005438 active site 665029005439 Zn2+ binding site [ion binding]; other site 665029005440 lipoprotein; Provisional; Region: PRK10540 665029005441 translation initiation factor Sui1; Validated; Region: PRK06824 665029005442 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 665029005443 putative rRNA binding site [nucleotide binding]; other site 665029005444 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 665029005445 active site 665029005446 dimer interface [polypeptide binding]; other site 665029005447 tetratricopeptide repeat protein; Provisional; Region: PRK11788 665029005448 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 665029005449 TPR motif; other site 665029005450 binding surface 665029005451 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 665029005452 binding surface 665029005453 TPR motif; other site 665029005454 Predicted membrane protein [Function unknown]; Region: COG3771 665029005455 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 665029005456 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 665029005457 active site 665029005458 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 665029005459 dimerization interface [polypeptide binding]; other site 665029005460 active site 665029005461 aconitate hydratase; Validated; Region: PRK09277 665029005462 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 665029005463 substrate binding site [chemical binding]; other site 665029005464 ligand binding site [chemical binding]; other site 665029005465 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 665029005466 substrate binding site [chemical binding]; other site 665029005467 transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681 665029005468 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 665029005469 The C-terminal substrate domain of LysR-type transcriptional regulator CysB contains type 2 periplasmic binding fold; Region: PBP2_CysB; cd08443 665029005470 substrate binding site [chemical binding]; other site 665029005471 putative dimerization interface [polypeptide binding]; other site 665029005472 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 665029005473 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 665029005474 active site 665029005475 interdomain interaction site; other site 665029005476 putative metal-binding site [ion binding]; other site 665029005477 nucleotide binding site [chemical binding]; other site 665029005478 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 665029005479 domain I; other site 665029005480 DNA binding groove [nucleotide binding] 665029005481 phosphate binding site [ion binding]; other site 665029005482 domain II; other site 665029005483 domain III; other site 665029005484 nucleotide binding site [chemical binding]; other site 665029005485 catalytic site [active] 665029005486 domain IV; other site 665029005487 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 665029005488 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 665029005489 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 665029005490 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 665029005491 Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496 665029005492 putative inner membrane peptidase; Provisional; Region: PRK11778 665029005493 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 665029005494 tandem repeat interface [polypeptide binding]; other site 665029005495 oligomer interface [polypeptide binding]; other site 665029005496 active site residues [active] 665029005497 putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945 665029005498 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 665029005499 NAD(P) binding site [chemical binding]; other site 665029005500 active site 665029005501 23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700 665029005502 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 665029005503 RNA binding surface [nucleotide binding]; other site 665029005504 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 665029005505 probable active site [active] 665029005506 hypothetical protein; Provisional; Region: PRK11630 665029005507 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 665029005508 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 665029005509 active site 665029005510 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 665029005511 anthranilate synthase component I; Provisional; Region: PRK13564 665029005512 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 665029005513 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 665029005514 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 665029005515 Glutamine amidotransferase class-I; Region: GATase; pfam00117 665029005516 glutamine binding [chemical binding]; other site 665029005517 catalytic triad [active] 665029005518 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 665029005519 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 665029005520 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 665029005521 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427 665029005522 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 665029005523 active site 665029005524 ribulose/triose binding site [chemical binding]; other site 665029005525 phosphate binding site [ion binding]; other site 665029005526 substrate (anthranilate) binding pocket [chemical binding]; other site 665029005527 product (indole) binding pocket [chemical binding]; other site 665029005528 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 665029005529 active site 665029005530 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 665029005531 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 665029005532 pyridoxal 5'-phosphate binding site [chemical binding]; other site 665029005533 catalytic residue [active] 665029005534 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 665029005535 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 665029005536 substrate binding site [chemical binding]; other site 665029005537 active site 665029005538 catalytic residues [active] 665029005539 heterodimer interface [polypeptide binding]; other site 665029005540 BON domain; Region: BON; pfam04972 665029005541 outer membrane protein W; Provisional; Region: PRK10959 665029005542 hypothetical protein; Provisional; Region: PRK02868 665029005543 intracellular septation protein A; Reviewed; Region: PRK00259 665029005544 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 665029005545 transport protein TonB; Provisional; Region: PRK10819 665029005546 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 665029005547 YciI-like protein; Reviewed; Region: PRK11370 665029005548 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 665029005549 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 665029005550 Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152 665029005551 putative active site [active] 665029005552 catalytic site [active] 665029005553 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158 665029005554 putative active site [active] 665029005555 catalytic site [active] 665029005556 dsDNA-mimic protein; Reviewed; Region: PRK05094 665029005557 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 665029005558 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 665029005559 Walker A/P-loop; other site 665029005560 ATP binding site [chemical binding]; other site 665029005561 Q-loop/lid; other site 665029005562 ABC transporter signature motif; other site 665029005563 Walker B; other site 665029005564 D-loop; other site 665029005565 H-loop/switch region; other site 665029005566 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 665029005567 oligopeptide transporter ATP-binding component; Provisional; Region: oppD; PRK09473 665029005568 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 665029005569 Walker A/P-loop; other site 665029005570 ATP binding site [chemical binding]; other site 665029005571 Q-loop/lid; other site 665029005572 ABC transporter signature motif; other site 665029005573 Walker B; other site 665029005574 D-loop; other site 665029005575 H-loop/switch region; other site 665029005576 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 665029005577 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 665029005578 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 665029005579 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 665029005580 dimer interface [polypeptide binding]; other site 665029005581 conserved gate region; other site 665029005582 putative PBP binding loops; other site 665029005583 ABC-ATPase subunit interface; other site 665029005584 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 665029005585 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; cl01074 665029005586 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 665029005587 dimer interface [polypeptide binding]; other site 665029005588 conserved gate region; other site 665029005589 putative PBP binding loops; other site 665029005590 ABC-ATPase subunit interface; other site 665029005591 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 665029005592 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 665029005593 peptide binding site [polypeptide binding]; other site 665029005594 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 665029005595 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 665029005596 peptide binding site [polypeptide binding]; other site 665029005597 hypothetical protein; Provisional; Region: PRK11111 665029005598 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 665029005599 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 665029005600 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 665029005601 NAD(P) binding site [chemical binding]; other site 665029005602 catalytic residues [active] 665029005603 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 665029005604 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 665029005605 putative active site [active] 665029005606 metal binding site [ion binding]; metal-binding site 665029005607 benzoate transport; Region: 2A0115; TIGR00895 665029005608 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 665029005609 putative substrate translocation pore; other site 665029005610 protocatechuate 4,5-dioxygenase; Provisional; Region: PRK13367 665029005611 The N-terminal domain of the Class III extradiol dioxygenase, Gallate Dioxygenase, which catalyzes the oxidization and subsequent ring-opening of gallate; Region: Gallate_Doxase_N; cd07950 665029005612 putative active site [active] 665029005613 Fe(II) binding site [ion binding]; other site 665029005614 putative dimer interface [polypeptide binding]; other site 665029005615 The C-terminal domain of Gallate Dioxygenase, which catalyzes the oxidization and subsequent ring-opening of gallate; Region: Gallate_dioxygenase_C; cd07923 665029005616 putative dimer interface [polypeptide binding]; other site 665029005617 putative N- and C-terminal domain interface [polypeptide binding]; other site 665029005618 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 665029005619 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 665029005620 active site 665029005621 Dehydroquinase class II; Region: DHquinase_II; pfam01220 665029005622 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 665029005623 trimer interface [polypeptide binding]; other site 665029005624 active site 665029005625 dimer interface [polypeptide binding]; other site 665029005626 Transcriptional regulator [Transcription]; Region: LysR; COG0583 665029005627 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 665029005628 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 665029005629 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 665029005630 The C-terminal substrate binding domain of galactose-binding protein regulator contains the type 2 periplasmic binding fold; Region: PBP2_GbpR; cd08435 665029005631 putative dimerization interface [polypeptide binding]; other site 665029005632 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 665029005633 hypothetical protein; Provisional; Region: PRK09262 665029005634 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2828 665029005635 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 665029005636 Domain of unknown function (DUF1932); Region: DUF1932; pfam09130 665029005637 Domain of unknown function (DUF336); Region: DUF336; pfam03928 665029005638 Membrane bound FAD containing D-sorbitol dehydrogenase; Region: FAD-SLDH; pfam12318 665029005639 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 665029005640 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 665029005641 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 665029005642 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 665029005643 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 665029005644 thymidine kinase; Provisional; Region: PRK04296 665029005645 global DNA-binding transcriptional dual regulator H-NS; Provisional; Region: PRK10947 665029005646 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 665029005647 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 665029005648 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 665029005649 putative NAD(P) binding site [chemical binding]; other site 665029005650 active site 665029005651 putative substrate binding site [chemical binding]; other site 665029005652 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 665029005653 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 665029005654 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 665029005655 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 665029005656 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 665029005657 active site 665029005658 tetramer interface; other site 665029005659 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 665029005660 active site 665029005661 response regulator of RpoS; Provisional; Region: PRK10693 665029005662 phosphorylation site [posttranslational modification] 665029005663 intermolecular recognition site; other site 665029005664 dimerization interface [polypeptide binding]; other site 665029005665 SEC-C motif; Region: SEC-C; pfam02810 665029005666 hypothetical protein; Provisional; Region: PRK04233 665029005667 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 665029005668 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 665029005669 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 665029005670 putative active site [active] 665029005671 putative substrate binding site [chemical binding]; other site 665029005672 putative cosubstrate binding site; other site 665029005673 catalytic site [active] 665029005674 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 665029005675 putative catalytic site [active] 665029005676 putative phosphate binding site [ion binding]; other site 665029005677 active site 665029005678 metal binding site A [ion binding]; metal-binding site 665029005679 DNA binding site [nucleotide binding] 665029005680 putative AP binding site [nucleotide binding]; other site 665029005681 putative metal binding site B [ion binding]; other site 665029005682 Protein of unknown function (DUF1496); Region: DUF1496; pfam07383 665029005683 DNA topoisomerase III; Provisional; Region: PRK07726 665029005684 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 665029005685 active site 665029005686 putative interdomain interaction site [polypeptide binding]; other site 665029005687 putative metal-binding site [ion binding]; other site 665029005688 putative nucleotide binding site [chemical binding]; other site 665029005689 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 665029005690 domain I; other site 665029005691 DNA binding groove [nucleotide binding] 665029005692 phosphate binding site [ion binding]; other site 665029005693 domain II; other site 665029005694 domain III; other site 665029005695 nucleotide binding site [chemical binding]; other site 665029005696 catalytic site [active] 665029005697 domain IV; other site 665029005698 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 665029005699 putative FMN binding site [chemical binding]; other site 665029005700 protease 4; Provisional; Region: PRK10949 665029005701 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 665029005702 tandem repeat interface [polypeptide binding]; other site 665029005703 oligomer interface [polypeptide binding]; other site 665029005704 active site residues [active] 665029005705 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 665029005706 tandem repeat interface [polypeptide binding]; other site 665029005707 oligomer interface [polypeptide binding]; other site 665029005708 active site residues [active] 665029005709 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 665029005710 active site 665029005711 homodimer interface [polypeptide binding]; other site 665029005712 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 665029005713 Isochorismatase family; Region: Isochorismatase; pfam00857 665029005714 catalytic triad [active] 665029005715 metal binding site [ion binding]; metal-binding site 665029005716 conserved cis-peptide bond; other site 665029005717 Protein of unknown function (DUF1315); Region: DUF1315; cl01215 665029005718 methionine sulfoxide reductase B; Provisional; Region: PRK00222 665029005719 SelR domain; Region: SelR; pfam01641 665029005720 glyceraldehyde-3-phosphate dehydrogenase A; Provisional; Region: gapA; PRK15425 665029005721 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 665029005722 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 665029005723 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 665029005724 active site 665029005725 phosphate binding residues; other site 665029005726 catalytic residues [active] 665029005727 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 665029005728 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 665029005729 active site 665029005730 catalytic tetrad [active] 665029005731 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 665029005732 PrkA family serine protein kinase; Provisional; Region: PRK15455 665029005733 AAA ATPase domain; Region: AAA_16; pfam13191 665029005734 Walker A motif; other site 665029005735 ATP binding site [chemical binding]; other site 665029005736 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 665029005737 hypothetical protein; Provisional; Region: PRK05325 665029005738 NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain [Inorganic ion transport and metabolism]; Region: COG3263 665029005739 TrkA-C domain; Region: TrkA_C; pfam02080 665029005740 Transporter associated domain; Region: CorC_HlyC; smart01091 665029005741 undecaprenyl-phosphate galactose phosphotransferase; Provisional; Region: PRK15204 665029005742 Bacterial sugar transferase; Region: Bac_transf; pfam02397 665029005743 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 665029005744 putative substrate translocation pore; other site 665029005745 Major Facilitator Superfamily; Region: MFS_1; pfam07690 665029005746 alanine racemase; Reviewed; Region: dadX; PRK03646 665029005747 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 665029005748 active site 665029005749 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 665029005750 substrate binding site [chemical binding]; other site 665029005751 catalytic residues [active] 665029005752 dimer interface [polypeptide binding]; other site 665029005753 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 665029005754 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 665029005755 hydroxyglutarate oxidase; Provisional; Region: PRK11728 665029005756 SpoVR family protein; Provisional; Region: PRK11767 665029005757 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 665029005758 fatty acid metabolism regulator; Provisional; Region: PRK04984 665029005759 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 665029005760 DNA-binding site [nucleotide binding]; DNA binding site 665029005761 FadR C-terminal domain; Region: FadR_C; pfam07840 665029005762 disulfide bond formation protein B; Provisional; Region: PRK01749 665029005763 hypothetical protein; Provisional; Region: PRK05170 665029005764 hypothetical protein; Provisional; Region: PRK10691 665029005765 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 665029005766 potential protein location (hypothetical protein predicted by Glimmer/Critica) that overlaps protein (hypothetical protein predicted by Glimmer/Critica) 665029005767 potential protein location (hypothetical protein predicted by Glimmer/Critica) that overlaps protein (hypothetical protein predicted by Glimmer/Critica) 665029005768 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3100 665029005769 septum formation inhibitor; Reviewed; Region: minC; PRK03511 665029005770 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 665029005771 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 665029005772 cell division inhibitor MinD; Provisional; Region: PRK10818 665029005773 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 665029005774 Switch I; other site 665029005775 Switch II; other site 665029005776 cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296 665029005777 ribonuclease D; Provisional; Region: PRK10829 665029005778 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 665029005779 catalytic site [active] 665029005780 putative active site [active] 665029005781 putative substrate binding site [chemical binding]; other site 665029005782 Helicase and RNase D C-terminal; Region: HRDC; smart00341 665029005783 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974 665029005784 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 665029005785 acyl-activating enzyme (AAE) consensus motif; other site 665029005786 putative AMP binding site [chemical binding]; other site 665029005787 putative active site [active] 665029005788 putative CoA binding site [chemical binding]; other site 665029005789 Outer membrane lipoprotein Slp family; Region: Slp; cl01164 665029005790 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 665029005791 Glycoprotease family; Region: Peptidase_M22; pfam00814 665029005792 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 665029005793 DEAD/DEAH box helicase; Region: DEAD; pfam00270 665029005794 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 665029005795 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 665029005796 homotrimer interaction site [polypeptide binding]; other site 665029005797 putative active site [active] 665029005798 hypothetical protein; Provisional; Region: PRK05114 665029005799 aminodeoxychorismate synthase subunit I; Provisional; Region: pabB; PRK15465 665029005800 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 665029005801 chorismate binding enzyme; Region: Chorismate_bind; cl10555 665029005802 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 665029005803 putative active site [active] 665029005804 putative CoA binding site [chemical binding]; other site 665029005805 nudix motif; other site 665029005806 metal binding site [ion binding]; metal-binding site 665029005807 L-serine deaminase; Provisional; Region: PRK15023 665029005808 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 665029005809 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 665029005810 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 665029005811 FOG: CBS domain [General function prediction only]; Region: COG0517 665029005812 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 665029005813 Transporter associated domain; Region: CorC_HlyC; smart01091 665029005814 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 665029005815 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 665029005816 S-adenosylmethionine binding site [chemical binding]; other site 665029005817 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 665029005818 DNA-binding site [nucleotide binding]; DNA binding site 665029005819 RNA-binding motif; other site 665029005820 Protein of unknown function (DUF2627); Region: DUF2527; pfam10736 665029005821 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 665029005822 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 665029005823 YebO-like protein; Region: YebO; pfam13974 665029005824 YobH-like protein; Region: YobH; pfam13996 665029005825 heat shock protein HtpX; Provisional; Region: PRK05457 665029005826 carboxy-terminal protease; Provisional; Region: PRK11186 665029005827 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 665029005828 protein binding site [polypeptide binding]; other site 665029005829 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 665029005830 Catalytic dyad [active] 665029005831 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 665029005832 ProP expression regulator; Provisional; Region: PRK04950 665029005833 ProQ/FINO family; Region: ProQ; pfam04352 665029005834 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 665029005835 GAF domain; Region: GAF_2; pfam13185 665029005836 Uncharacterized paraquat-inducible protein A [Function unknown]; Region: PqiA; COG2995 665029005837 Paraquat-inducible protein A; Region: PqiA; pfam04403 665029005838 Paraquat-inducible protein A; Region: PqiA; pfam04403 665029005839 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 665029005840 mce related protein; Region: MCE; pfam02470 665029005841 mce related protein; Region: MCE; pfam02470 665029005842 mce related protein; Region: MCE; pfam02470 665029005843 mce related protein; Region: MCE; pfam02470 665029005844 mce related protein; Region: MCE; pfam02470 665029005845 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 665029005846 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 665029005847 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 665029005848 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 665029005849 Domain of unknown function DUF20; Region: UPF0118; pfam01594 665029005850 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 665029005851 Membrane protein of unknown function (DUF340); Region: DUF340; pfam03956 665029005852 Biofilm formation and stress response factor; Region: BsmA; pfam10014 665029005853 putative membrane protein, TIGR04086 family; Region: TIGR04086_membr 665029005854 Protein of unknown function (DUF2511); Region: DUF2511; pfam10709 665029005855 DNA polymerase III subunit theta; Reviewed; Region: PRK10969 665029005856 exodeoxyribonuclease X; Provisional; Region: PRK07983 665029005857 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 665029005858 active site 665029005859 catalytic site [active] 665029005860 substrate binding site [chemical binding]; other site 665029005861 protease 2; Provisional; Region: PRK10115 665029005862 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 665029005863 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 665029005864 YebG protein; Region: YebG; pfam07130 665029005865 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 665029005866 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 665029005867 ATP-grasp domain; Region: ATP-grasp; pfam02222 665029005868 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 665029005869 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 665029005870 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 665029005871 pyruvate kinase; Provisional; Region: PRK05826 665029005872 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 665029005873 domain interfaces; other site 665029005874 active site 665029005875 multidrug efflux system translocase MdfA; Provisional; Region: PRK15402 665029005876 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 665029005877 putative substrate translocation pore; other site 665029005878 Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; cl01974 665029005879 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 665029005880 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 665029005881 putative acyl-acceptor binding pocket; other site 665029005882 putative peptidase; Provisional; Region: PRK11649 665029005883 Opacity-associated protein A N-terminal motif; Region: OapA_N; pfam08525 665029005884 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 665029005885 Peptidase family M23; Region: Peptidase_M23; pfam01551 665029005886 high-affinity zinc transporter periplasmic component; Reviewed; Region: znuA; PRK09545 665029005887 Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019 665029005888 metal binding site [ion binding]; metal-binding site 665029005889 high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544 665029005890 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 665029005891 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 665029005892 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 665029005893 ABC-ATPase subunit interface; other site 665029005894 dimer interface [polypeptide binding]; other site 665029005895 putative PBP binding regions; other site 665029005896 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 665029005897 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 665029005898 Walker A motif; other site 665029005899 ATP binding site [chemical binding]; other site 665029005900 Walker B motif; other site 665029005901 arginine finger; other site 665029005902 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 665029005903 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 665029005904 RuvA N terminal domain; Region: RuvA_N; pfam01330 665029005905 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 665029005906 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 665029005907 active site 665029005908 putative DNA-binding cleft [nucleotide binding]; other site 665029005909 dimer interface [polypeptide binding]; other site 665029005910 hypothetical protein; Validated; Region: PRK00110 665029005911 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 665029005912 nudix motif; other site 665029005913 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 665029005914 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 665029005915 dimer interface [polypeptide binding]; other site 665029005916 anticodon binding site; other site 665029005917 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 665029005918 homodimer interface [polypeptide binding]; other site 665029005919 motif 1; other site 665029005920 active site 665029005921 motif 2; other site 665029005922 GAD domain; Region: GAD; pfam02938 665029005923 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 665029005924 active site 665029005925 motif 3; other site 665029005926 hypothetical protein; Provisional; Region: PRK10302 665029005927 Uncharacterized relative of glutathione S-transferase, MAPEG superfamily [General function prediction only]; Region: COG3788 665029005928 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 665029005929 S-adenosylmethionine binding site [chemical binding]; other site 665029005930 Methyltransferase domain; Region: Methyltransf_31; pfam13847 665029005931 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 665029005932 S-adenosylmethionine binding site [chemical binding]; other site 665029005933 copper homeostasis protein CutC; Provisional; Region: PRK11572 665029005934 putative C-S lyase; Region: C_S_lyase_PatB; TIGR04350 665029005935 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 665029005936 pyridoxal 5'-phosphate binding site [chemical binding]; other site 665029005937 homodimer interface [polypeptide binding]; other site 665029005938 catalytic residue [active] 665029005939 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_4; cd07268 665029005940 putative metal binding site [ion binding]; other site 665029005941 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 665029005942 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 665029005943 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 665029005944 active site 665029005945 HIGH motif; other site 665029005946 KMSK motif region; other site 665029005947 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 665029005948 tRNA binding surface [nucleotide binding]; other site 665029005949 anticodon binding site; other site 665029005950 Flagellar protein FlhE; Region: FlhE; pfam06366 665029005951 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 665029005952 FHIPEP family; Region: FHIPEP; pfam00771 665029005953 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK12468 665029005954 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 665029005955 chemotaxis regulator CheZ; Provisional; Region: PRK11166 665029005956 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 665029005957 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 665029005958 active site 665029005959 phosphorylation site [posttranslational modification] 665029005960 intermolecular recognition site; other site 665029005961 dimerization interface [polypeptide binding]; other site 665029005962 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 665029005963 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 665029005964 active site 665029005965 phosphorylation site [posttranslational modification] 665029005966 intermolecular recognition site; other site 665029005967 dimerization interface [polypeptide binding]; other site 665029005968 CheB methylesterase; Region: CheB_methylest; pfam01339 665029005969 chemotaxis methyltransferase CheR; Provisional; Region: PRK10611 665029005970 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 665029005971 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 665029005972 S-adenosylmethionine binding site [chemical binding]; other site 665029005973 methyl-accepting protein IV; Provisional; Region: PRK09793 665029005974 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 665029005975 dimer interface [polypeptide binding]; other site 665029005976 ligand binding site [chemical binding]; other site 665029005977 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 665029005978 dimerization interface [polypeptide binding]; other site 665029005979 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 665029005980 dimer interface [polypeptide binding]; other site 665029005981 putative CheW interface [polypeptide binding]; other site 665029005982 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 665029005983 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 665029005984 dimer interface [polypeptide binding]; other site 665029005985 ligand binding site [chemical binding]; other site 665029005986 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 665029005987 dimerization interface [polypeptide binding]; other site 665029005988 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 665029005989 dimer interface [polypeptide binding]; other site 665029005990 putative CheW interface [polypeptide binding]; other site 665029005991 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 665029005992 putative CheA interaction surface; other site 665029005993 chemotaxis protein CheA; Provisional; Region: PRK10547 665029005994 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 665029005995 putative binding surface; other site 665029005996 active site 665029005997 CheY binding; Region: CheY-binding; pfam09078 665029005998 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 665029005999 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 665029006000 ATP binding site [chemical binding]; other site 665029006001 Mg2+ binding site [ion binding]; other site 665029006002 G-X-G motif; other site 665029006003 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 665029006004 flagellar motor protein MotB; Validated; Region: motB; PRK09041 665029006005 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 665029006006 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 665029006007 ligand binding site [chemical binding]; other site 665029006008 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 665029006009 flagellar motor protein MotA; Validated; Region: PRK09110 665029006010 transcriptional activator FlhC; Provisional; Region: PRK12722 665029006011 transcriptional activator FlhD; Provisional; Region: PRK02909 665029006012 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 665029006013 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 665029006014 active site 665029006015 homotetramer interface [polypeptide binding]; other site 665029006016 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 665029006017 Trehalose-phosphatase; Region: Trehalose_PPase; pfam02358 665029006018 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 665029006019 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 665029006020 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 665029006021 Catalytic site [active] 665029006022 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 665029006023 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 665029006024 active site 665029006025 DNA binding site [nucleotide binding] 665029006026 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 665029006027 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 665029006028 dimer interface [polypeptide binding]; other site 665029006029 active site 665029006030 Schiff base residues; other site 665029006031 Predicted flavoprotein [General function prediction only]; Region: COG0431 665029006032 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 665029006033 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 665029006034 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 665029006035 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 665029006036 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 665029006037 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 665029006038 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 665029006039 active site 665029006040 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 665029006041 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 665029006042 Na binding site [ion binding]; other site 665029006043 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 665029006044 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 665029006045 NAD(P) binding site [chemical binding]; other site 665029006046 catalytic residues [active] 665029006047 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 665029006048 EamA-like transporter family; Region: EamA; pfam00892 665029006049 EamA-like transporter family; Region: EamA; pfam00892 665029006050 Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381 665029006051 alkaline phosphatase; Provisional; Region: PRK10518 665029006052 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 665029006053 dimer interface [polypeptide binding]; other site 665029006054 active site 665029006055 potential frameshift: common BLAST hit: gi|259908167|ref|YP_002648523.1| Probable nitroreductase 665029006056 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 665029006057 FMN binding site [chemical binding]; other site 665029006058 potential frameshift: common BLAST hit: gi|188533578|ref|YP_001907375.1| Probable nitroreductase 665029006059 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 665029006060 hypothetical protein; Provisional; Region: PRK10536 665029006061 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 665029006062 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 665029006063 formate dehydrogenase region TAT target; Region: formate_TAT; TIGR02811 665029006064 Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837 665029006065 inactive ferrous ion transporter periplasmic protein EfeO; Provisional; Region: PRK10378 665029006066 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 665029006067 Imelysin; Region: Peptidase_M75; pfam09375 665029006068 Iron permease FTR1 family; Region: FTR1; cl00475 665029006069 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 665029006070 Na binding site [ion binding]; other site 665029006071 trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: putA; PRK11809 665029006072 Predicted transcriptional regulator [Transcription]; Region: COG3905 665029006073 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 665029006074 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 665029006075 Glutamate binding site [chemical binding]; other site 665029006076 NAD binding site [chemical binding]; other site 665029006077 catalytic residues [active] 665029006078 Predicted membrane protein [Function unknown]; Region: COG4763 665029006079 Acyltransferase family; Region: Acyl_transf_3; pfam01757 665029006080 potential frameshift: common BLAST hit: gi|218548544|ref|YP_002382335.1| D-cysteine desulfhydrase 665029006081 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 665029006082 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 665029006083 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 665029006084 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 665029006085 flagella biosynthesis protein FliZ; Provisional; Region: PRK11582 665029006086 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 665029006087 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 665029006088 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 665029006089 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 665029006090 DNA binding residues [nucleotide binding] 665029006091 HNH endonuclease; Region: HNH_2; pfam13391 665029006092 flagellin; Provisional; Region: PRK12802 665029006093 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 665029006094 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 665029006095 flagellar capping protein; Reviewed; Region: fliD; PRK08032 665029006096 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 665029006097 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 665029006098 flagellar protein FliS; Validated; Region: fliS; PRK05685 665029006099 flagellar biosynthesis protein FliT; Provisional; Region: PRK10548 665029006100 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 665029006101 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 665029006102 active site 665029006103 Na/Ca binding site [ion binding]; other site 665029006104 catalytic site [active] 665029006105 Domain of unknown function (DUF1939); Region: DUF1939; pfam09154 665029006106 lipoprotein; Provisional; Region: PRK10397 665029006107 hypothetical protein; Provisional; Region: PRK10062 665029006108 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 665029006109 additional DNA contacts [nucleotide binding]; other site 665029006110 mismatch recognition site; other site 665029006111 active site 665029006112 zinc binding site [ion binding]; other site 665029006113 DNA intercalation site [nucleotide binding]; other site 665029006114 DNA cytosine methylase; Provisional; Region: PRK10458 665029006115 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 665029006116 cofactor binding site; other site 665029006117 DNA binding site [nucleotide binding] 665029006118 substrate interaction site [chemical binding]; other site 665029006119 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1636 665029006120 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 665029006121 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 665029006122 Zn2+ binding site [ion binding]; other site 665029006123 Mg2+ binding site [ion binding]; other site 665029006124 ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020 665029006125 DgsA anti-repressor MtfA; Provisional; Region: PRK15410 665029006126 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 665029006127 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 665029006128 heme binding site [chemical binding]; other site 665029006129 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 665029006130 heme binding site [chemical binding]; other site 665029006131 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 665029006132 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 665029006133 metal binding site [ion binding]; metal-binding site 665029006134 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 665029006135 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 665029006136 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 665029006137 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 665029006138 ABC-ATPase subunit interface; other site 665029006139 dimer interface [polypeptide binding]; other site 665029006140 putative PBP binding regions; other site 665029006141 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 665029006142 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 665029006143 ABC-ATPase subunit interface; other site 665029006144 dimer interface [polypeptide binding]; other site 665029006145 putative PBP binding regions; other site 665029006146 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 665029006147 active site 665029006148 ATP binding site [chemical binding]; other site 665029006149 substrate binding site [chemical binding]; other site 665029006150 hypothetical protein; Provisional; Region: PRK06185 665029006151 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 665029006152 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 665029006153 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 665029006154 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 665029006155 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 665029006156 intersubunit interface [polypeptide binding]; other site 665029006157 microcin C ABC transporter ATP-binding protein YejF; Provisional; Region: PRK15134 665029006158 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 665029006159 Walker A/P-loop; other site 665029006160 ATP binding site [chemical binding]; other site 665029006161 Q-loop/lid; other site 665029006162 ABC transporter signature motif; other site 665029006163 Walker B; other site 665029006164 D-loop; other site 665029006165 H-loop/switch region; other site 665029006166 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 665029006167 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 665029006168 Walker A/P-loop; other site 665029006169 ATP binding site [chemical binding]; other site 665029006170 Q-loop/lid; other site 665029006171 ABC transporter signature motif; other site 665029006172 Walker B; other site 665029006173 D-loop; other site 665029006174 H-loop/switch region; other site 665029006175 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 665029006176 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 665029006177 dimer interface [polypeptide binding]; other site 665029006178 conserved gate region; other site 665029006179 putative PBP binding loops; other site 665029006180 ABC-ATPase subunit interface; other site 665029006181 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 665029006182 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 665029006183 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 665029006184 ABC-ATPase subunit interface; other site 665029006185 putative PBP binding loops; other site 665029006186 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 665029006187 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_3; cd08490 665029006188 Glycogenin belongs the GT 8 family and initiates the biosynthesis of glycogen; Region: GT8_Glycogenin; cd02537 665029006189 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 665029006190 substrate binding site; other site 665029006191 Manganese binding site; other site 665029006192 dimer interface; other site 665029006193 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 665029006194 potential frameshift: common BLAST hit: gi|259908122|ref|YP_002648478.1| GCN5-related N-acetyltransferase 665029006195 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 665029006196 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 665029006197 transcriptional regulator Cbl; Reviewed; Region: cbl; PRK12679 665029006198 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 665029006199 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 665029006200 dimerization interface [polypeptide binding]; other site 665029006201 nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233 665029006202 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 665029006203 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 665029006204 putative dimerization interface [polypeptide binding]; other site 665029006205 potential protein location (hypothetical protein predicted by Glimmer/Critica) that overlaps protein (Protein ea31) 665029006206 AAA domain; Region: AAA_21; pfam13304 665029006207 V-type ATP synthase subunit E; Provisional; Region: PRK02292 665029006208 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 665029006209 Predicted membrane protein [Function unknown]; Region: COG2323 665029006210 AMP nucleosidase; Provisional; Region: PRK08292 665029006211 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 665029006212 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 665029006213 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 665029006214 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 665029006215 putative NAD(P) binding site [chemical binding]; other site 665029006216 catalytic Zn binding site [ion binding]; other site 665029006217 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 665029006218 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 665029006219 Walker A motif; other site 665029006220 ATP binding site [chemical binding]; other site 665029006221 Walker B motif; other site 665029006222 arginine finger; other site 665029006223 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 665029006224 DNA-binding interface [nucleotide binding]; DNA binding site 665029006225 potential protein location (hypothetical protein predicted by Glimmer/Critica) that overlaps protein (hypothetical protein predicted by Glimmer/Critica) 665029006226 potential protein location (hypothetical protein predicted by Glimmer/Critica) that overlaps protein (hypothetical protein predicted by Glimmer/Critica) 665029006227 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 665029006228 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 665029006229 dimerization interface [polypeptide binding]; other site 665029006230 putative DNA binding site [nucleotide binding]; other site 665029006231 putative Zn2+ binding site [ion binding]; other site 665029006232 AsnC family; Region: AsnC_trans_reg; pfam01037 665029006233 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 665029006234 Protein of unknown function (DUF2000); Region: DUF2000; cl02074 665029006235 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 665029006236 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 665029006237 acyl-activating enzyme (AAE) consensus motif; other site 665029006238 AMP binding site [chemical binding]; other site 665029006239 active site 665029006240 CoA binding site [chemical binding]; other site 665029006241 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 665029006242 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 665029006243 homodimer interface [polypeptide binding]; other site 665029006244 substrate-cofactor binding pocket; other site 665029006245 pyridoxal 5'-phosphate binding site [chemical binding]; other site 665029006246 catalytic residue [active] 665029006247 PBP superfamily domain; Region: PBP_like; cl17867 665029006248 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 665029006249 Uncharacterized conserved protein [Function unknown]; Region: COG2128 665029006250 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 665029006251 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 665029006252 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 665029006253 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 665029006254 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 665029006255 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 665029006256 active site 665029006257 FMN binding site [chemical binding]; other site 665029006258 substrate binding site [chemical binding]; other site 665029006259 homotetramer interface [polypeptide binding]; other site 665029006260 catalytic residue [active] 665029006261 MATE family multidrug exporter; Provisional; Region: PRK10189 665029006262 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 665029006263 hypothetical protein; Provisional; Region: PRK05423 665029006264 Predicted membrane protein [Function unknown]; Region: COG1289 665029006265 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 665029006266 exonuclease I; Provisional; Region: sbcB; PRK11779 665029006267 N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138 665029006268 active site 665029006269 catalytic site [active] 665029006270 substrate binding site [chemical binding]; other site 665029006271 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 665029006272 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 665029006273 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 665029006274 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 665029006275 putative NAD(P) binding site [chemical binding]; other site 665029006276 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 665029006277 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 665029006278 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 665029006279 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 665029006280 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 665029006281 NAD binding site [chemical binding]; other site 665029006282 dimerization interface [polypeptide binding]; other site 665029006283 product binding site; other site 665029006284 substrate binding site [chemical binding]; other site 665029006285 zinc binding site [ion binding]; other site 665029006286 catalytic residues [active] 665029006287 histidinol-phosphate aminotransferase; Provisional; Region: PRK01688 665029006288 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 665029006289 pyridoxal 5'-phosphate binding site [chemical binding]; other site 665029006290 homodimer interface [polypeptide binding]; other site 665029006291 catalytic residue [active] 665029006292 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446 665029006293 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 665029006294 active site 665029006295 motif I; other site 665029006296 motif II; other site 665029006297 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 665029006298 putative active site pocket [active] 665029006299 4-fold oligomerization interface [polypeptide binding]; other site 665029006300 metal binding residues [ion binding]; metal-binding site 665029006301 3-fold/trimer interface [polypeptide binding]; other site 665029006302 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13170 665029006303 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 665029006304 putative active site [active] 665029006305 oxyanion strand; other site 665029006306 catalytic triad [active] 665029006307 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 665029006308 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 665029006309 catalytic residues [active] 665029006310 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 665029006311 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 665029006312 substrate binding site [chemical binding]; other site 665029006313 glutamase interaction surface [polypeptide binding]; other site 665029006314 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 665029006315 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 665029006316 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 665029006317 metal binding site [ion binding]; metal-binding site 665029006318 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 665029006319 putative deacylase active site [active] 665029006320 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 665029006321 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 665029006322 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 665029006323 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 665029006324 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 665029006325 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 665029006326 putative ADP-binding pocket [chemical binding]; other site 665029006327 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 665029006328 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 665029006329 active site 665029006330 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 665029006331 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 665029006332 UDP-galactopyranose mutase; Region: GLF; pfam03275 665029006333 Domain of unknown function (DUF4422); Region: DUF4422; pfam14393 665029006334 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 665029006335 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 665029006336 Ligand binding site; other site 665029006337 metal-binding site 665029006338 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 665029006339 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 665029006340 Walker A/P-loop; other site 665029006341 ATP binding site [chemical binding]; other site 665029006342 Q-loop/lid; other site 665029006343 ABC transporter signature motif; other site 665029006344 Walker B; other site 665029006345 D-loop; other site 665029006346 H-loop/switch region; other site 665029006347 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 665029006348 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 665029006349 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 665029006350 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 665029006351 NAD(P) binding site [chemical binding]; other site 665029006352 active site 665029006353 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 665029006354 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 665029006355 substrate binding site; other site 665029006356 tetramer interface; other site 665029006357 dTDP-glucose 4,6 dehydratase; Provisional; Region: PRK10084 665029006358 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 665029006359 NAD binding site [chemical binding]; other site 665029006360 substrate binding site [chemical binding]; other site 665029006361 homodimer interface [polypeptide binding]; other site 665029006362 active site 665029006363 UDP-glucose 4-epimerase; Region: PLN02240 665029006364 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 665029006365 NAD binding site [chemical binding]; other site 665029006366 homodimer interface [polypeptide binding]; other site 665029006367 active site 665029006368 substrate binding site [chemical binding]; other site 665029006369 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 665029006370 active site 665029006371 tetramer interface; other site 665029006372 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 665029006373 colanic acid biosynthesis glycosyltransferase WcaL; Provisional; Region: PRK15427 665029006374 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 665029006375 putative ADP-binding pocket [chemical binding]; other site 665029006376 colanic acid biosynthesis protein; Provisional; Region: PRK10017 665029006377 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327 665029006378 Head binding; Region: Head_binding; pfam09008 665029006379 GT2_AmsE_like is involved in exopolysaccharide amylovora biosynthesis; Region: GT2_AmsE_like; cd04195 665029006380 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 665029006381 This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820 665029006382 putative ADP-binding pocket [chemical binding]; other site 665029006383 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 665029006384 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 665029006385 active site 665029006386 tyrosine kinase; Provisional; Region: PRK11519 665029006387 Chain length determinant protein; Region: Wzz; pfam02706 665029006388 Chain length determinant protein; Region: Wzz; cl15801 665029006389 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 665029006390 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 665029006391 P loop; other site 665029006392 Nucleotide binding site [chemical binding]; other site 665029006393 DTAP/Switch II; other site 665029006394 Switch I; other site 665029006395 Low molecular weight phosphatase family; Region: LMWPc; cd00115 665029006396 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 665029006397 active site 665029006398 polysaccharide export protein Wza; Provisional; Region: PRK15078 665029006399 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 665029006400 SLBB domain; Region: SLBB; pfam10531 665029006401 SLBB domain; Region: SLBB; pfam10531 665029006402 undecaprenyl-phosphate galactose phosphotransferase; Provisional; Region: PRK15204 665029006403 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 665029006404 Bacterial sugar transferase; Region: Bac_transf; pfam02397 665029006405 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 665029006406 FOG: CBS domain [General function prediction only]; Region: COG0517 665029006407 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 665029006408 Transporter associated domain; Region: CorC_HlyC; smart01091 665029006409 putative assembly protein; Provisional; Region: PRK10833 665029006410 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 665029006411 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 665029006412 trimer interface [polypeptide binding]; other site 665029006413 active site 665029006414 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 665029006415 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 665029006416 ATP-binding site [chemical binding]; other site 665029006417 Sugar specificity; other site 665029006418 Pyrimidine base specificity; other site 665029006419 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 665029006420 active site 665029006421 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 665029006422 Predicted integral membrane sensor domain [Signal transduction mechanisms]; Region: COG3447 665029006423 PAS domain S-box; Region: sensory_box; TIGR00229 665029006424 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 665029006425 putative active site [active] 665029006426 heme pocket [chemical binding]; other site 665029006427 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 665029006428 PAS fold; Region: PAS_3; pfam08447 665029006429 putative active site [active] 665029006430 heme pocket [chemical binding]; other site 665029006431 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 665029006432 PAS domain; Region: PAS_9; pfam13426 665029006433 putative active site [active] 665029006434 heme pocket [chemical binding]; other site 665029006435 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 665029006436 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 665029006437 metal binding site [ion binding]; metal-binding site 665029006438 active site 665029006439 I-site; other site 665029006440 putative chaperone; Provisional; Region: PRK11678 665029006441 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 665029006442 nucleotide binding site [chemical binding]; other site 665029006443 putative NEF/HSP70 interaction site [polypeptide binding]; other site 665029006444 SBD interface [polypeptide binding]; other site 665029006445 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 665029006446 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 665029006447 active site 665029006448 catalytic tetrad [active] 665029006449 multidrug efflux system subunit MdtA; Provisional; Region: PRK11556 665029006450 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 665029006451 HlyD family secretion protein; Region: HlyD_3; pfam13437 665029006452 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 665029006453 Protein export membrane protein; Region: SecD_SecF; cl14618 665029006454 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 665029006455 signal transduction histidine-protein kinase BaeS; Provisional; Region: PRK10549 665029006456 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 665029006457 dimerization interface [polypeptide binding]; other site 665029006458 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 665029006459 dimer interface [polypeptide binding]; other site 665029006460 phosphorylation site [posttranslational modification] 665029006461 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 665029006462 ATP binding site [chemical binding]; other site 665029006463 Mg2+ binding site [ion binding]; other site 665029006464 G-X-G motif; other site 665029006465 DNA-binding transcriptional regulator BaeR; Provisional; Region: PRK10710 665029006466 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 665029006467 active site 665029006468 phosphorylation site [posttranslational modification] 665029006469 intermolecular recognition site; other site 665029006470 dimerization interface [polypeptide binding]; other site 665029006471 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 665029006472 DNA binding site [nucleotide binding] 665029006473 putative protease; Provisional; Region: PRK15452 665029006474 putative protease; Provisional; Region: PRK15452 665029006475 Tir chaperone protein (CesT) family; Region: CesT; cl08444 665029006476 lipid kinase; Reviewed; Region: PRK13054 665029006477 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 665029006478 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 665029006479 dimer interface [polypeptide binding]; other site 665029006480 substrate binding site [chemical binding]; other site 665029006481 ATP binding site [chemical binding]; other site 665029006482 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 665029006483 substrate binding site [chemical binding]; other site 665029006484 multimerization interface [polypeptide binding]; other site 665029006485 ATP binding site [chemical binding]; other site 665029006486 chorismate mutase; Provisional; Region: PRK08055 665029006487 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 665029006488 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 665029006489 Coenzyme A binding pocket [chemical binding]; other site 665029006490 antiporter inner membrane protein; Provisional; Region: PRK11670 665029006491 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 665029006492 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 665029006493 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 665029006494 active site 665029006495 HIGH motif; other site 665029006496 KMSKS motif; other site 665029006497 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 665029006498 tRNA binding surface [nucleotide binding]; other site 665029006499 anticodon binding site; other site 665029006500 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 665029006501 dimer interface [polypeptide binding]; other site 665029006502 putative tRNA-binding site [nucleotide binding]; other site 665029006503 hypothetical protein; Provisional; Region: PRK01821 665029006504 potential frameshift: common BLAST hit: gi|259908019|ref|YP_002648375.1| transmembrane protein YohK 665029006505 LrgB-like family; Region: LrgB; cl00596 665029006506 LrgB-like family; Region: LrgB; cl00596 665029006507 cytidine deaminase; Provisional; Region: PRK09027 665029006508 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 665029006509 active site 665029006510 catalytic motif [active] 665029006511 Zn binding site [ion binding]; other site 665029006512 Cytidine and deoxycytidylate deaminase zinc-binding region; Region: dCMP_cyt_deam_2; pfam08211 665029006513 malate dehydrogenase; Provisional; Region: PRK13529 665029006514 Malic enzyme, N-terminal domain; Region: malic; pfam00390 665029006515 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 665029006516 NAD(P) binding site [chemical binding]; other site 665029006517 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 665029006518 putative active site [active] 665029006519 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 665029006520 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 665029006521 TM-ABC transporter signature motif; other site 665029006522 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 665029006523 galactose/methyl galaxtoside transporter ATP-binding protein; Provisional; Region: PRK10982 665029006524 Walker A/P-loop; other site 665029006525 ATP binding site [chemical binding]; other site 665029006526 Q-loop/lid; other site 665029006527 ABC transporter signature motif; other site 665029006528 Walker B; other site 665029006529 D-loop; other site 665029006530 H-loop/switch region; other site 665029006531 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 665029006532 methyl-galactoside ABC transporter galactose-binding periplasmic protein MglB; Provisional; Region: PRK15395 665029006533 Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539 665029006534 ligand binding site [chemical binding]; other site 665029006535 calcium binding site [ion binding]; other site 665029006536 DNA-binding transcriptional regulator GalS; Provisional; Region: PRK10401 665029006537 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 665029006538 DNA binding site [nucleotide binding] 665029006539 domain linker motif; other site 665029006540 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 665029006541 dimerization interface (closed form) [polypeptide binding]; other site 665029006542 ligand binding site [chemical binding]; other site 665029006543 Predicted membrane protein [Function unknown]; Region: COG2311 665029006544 hypothetical protein; Provisional; Region: PRK10835 665029006545 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 665029006546 homodecamer interface [polypeptide binding]; other site 665029006547 GTP cyclohydrolase I; Provisional; Region: PLN03044 665029006548 active site 665029006549 putative catalytic site residues [active] 665029006550 zinc binding site [ion binding]; other site 665029006551 GTP-CH-I/GFRP interaction surface; other site 665029006552 Transcriptional regulator [Transcription]; Region: LysR; COG0583 665029006553 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 665029006554 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 665029006555 putative dimerization interface [polypeptide binding]; other site 665029006556 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 665029006557 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 665029006558 substrate binding site [chemical binding]; other site 665029006559 catalytic Zn binding site [ion binding]; other site 665029006560 NAD binding site [chemical binding]; other site 665029006561 structural Zn binding site [ion binding]; other site 665029006562 dimer interface [polypeptide binding]; other site 665029006563 S-formylglutathione hydrolase; Region: PLN02442 665029006564 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 665029006565 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 665029006566 Peptidase S8 family domain, uncharacterized subfamily 11; Region: Peptidases_S8_11; cd04843 665029006567 putative active site [active] 665029006568 putative catalytic triad [active] 665029006569 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 665029006570 aromatic chitin/cellulose binding site residues [chemical binding]; other site 665029006571 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 665029006572 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 665029006573 Walker A/P-loop; other site 665029006574 ATP binding site [chemical binding]; other site 665029006575 Q-loop/lid; other site 665029006576 ABC transporter signature motif; other site 665029006577 Walker B; other site 665029006578 D-loop; other site 665029006579 H-loop/switch region; other site 665029006580 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 665029006581 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 665029006582 dimer interface [polypeptide binding]; other site 665029006583 putative PBP binding regions; other site 665029006584 ABC-ATPase subunit interface; other site 665029006585 lysine transporter; Provisional; Region: PRK10836 665029006586 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 665029006587 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 665029006588 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 665029006589 putative dimerization interface [polypeptide binding]; other site 665029006590 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 665029006591 endonuclease IV; Provisional; Region: PRK01060 665029006592 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 665029006593 AP (apurinic/apyrimidinic) site pocket; other site 665029006594 DNA interaction; other site 665029006595 Metal-binding active site; metal-binding site 665029006596 PTS system fructose-specific transporter subunits IIBC; Provisional; Region: PRK10712 665029006597 N-terminal domain of the phosphotransferase system fructose-specific component IIB [Carbohydrate transport and metabolism]; Region: COG3925 665029006598 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 665029006599 active site 665029006600 P-loop; other site 665029006601 phosphorylation site [posttranslational modification] 665029006602 PTS system, fructose subfamily, IIC component; Region: PTS_IIC_fructo; TIGR01427 665029006603 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 665029006604 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 665029006605 putative substrate binding site [chemical binding]; other site 665029006606 putative ATP binding site [chemical binding]; other site 665029006607 bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional; Region: PRK11109 665029006608 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 665029006609 active site 665029006610 phosphorylation site [posttranslational modification] 665029006611 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 665029006612 dimerization domain swap beta strand [polypeptide binding]; other site 665029006613 regulatory protein interface [polypeptide binding]; other site 665029006614 active site 665029006615 regulatory phosphorylation site [posttranslational modification]; other site 665029006616 Flagellin N-methylase; Region: FliB; cl00497 665029006617 elongation factor P; Provisional; Region: PRK04542 665029006618 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 665029006619 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 665029006620 RNA binding site [nucleotide binding]; other site 665029006621 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 665029006622 RNA binding site [nucleotide binding]; other site 665029006623 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 665029006624 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 665029006625 active site 665029006626 outer membrane lipoprotein; Provisional; Region: spr; PRK10838 665029006627 NlpC/P60 family; Region: NLPC_P60; pfam00877 665029006628 phage resistance protein; Provisional; Region: PRK10551 665029006629 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 665029006630 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 665029006631 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 665029006632 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 665029006633 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 665029006634 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 665029006635 dimer interface [polypeptide binding]; other site 665029006636 conserved gate region; other site 665029006637 putative PBP binding loops; other site 665029006638 ABC-ATPase subunit interface; other site 665029006639 microcin C ABC transporter permease; Provisional; Region: PRK15021 665029006640 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 665029006641 dimer interface [polypeptide binding]; other site 665029006642 conserved gate region; other site 665029006643 ABC-ATPase subunit interface; other site 665029006644 microcin C ABC transporter ATP-binding protein YejF; Provisional; Region: PRK15134 665029006645 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 665029006646 Walker A/P-loop; other site 665029006647 ATP binding site [chemical binding]; other site 665029006648 Q-loop/lid; other site 665029006649 ABC transporter signature motif; other site 665029006650 Walker B; other site 665029006651 D-loop; other site 665029006652 H-loop/switch region; other site 665029006653 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 665029006654 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 665029006655 Walker A/P-loop; other site 665029006656 ATP binding site [chemical binding]; other site 665029006657 Q-loop/lid; other site 665029006658 ABC transporter signature motif; other site 665029006659 Walker B; other site 665029006660 D-loop; other site 665029006661 H-loop/switch region; other site 665029006662 hypothetical protein; Provisional; Region: PRK11835 665029006663 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 665029006664 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 665029006665 putative substrate translocation pore; other site 665029006666 16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839 665029006667 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 665029006668 RNA binding surface [nucleotide binding]; other site 665029006669 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 665029006670 active site 665029006671 uracil binding [chemical binding]; other site 665029006672 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 665029006673 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 665029006674 ATP binding site [chemical binding]; other site 665029006675 putative Mg++ binding site [ion binding]; other site 665029006676 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 665029006677 nucleotide binding region [chemical binding]; other site 665029006678 ATP-binding site [chemical binding]; other site 665029006679 Ribosomal L40e family; Region: Ribosomal_L40e; cl00671 665029006680 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 665029006681 5S rRNA interface [nucleotide binding]; other site 665029006682 CTC domain interface [polypeptide binding]; other site 665029006683 L16 interface [polypeptide binding]; other site 665029006684 Nucleoid-associated protein [General function prediction only]; Region: COG3081 665029006685 nucleoid-associated protein NdpA; Validated; Region: PRK00378 665029006686 hypothetical protein; Provisional; Region: PRK13689 665029006687 Predicted hydrolase of alkaline phosphatase superfamily [General function prediction only]; Region: COG3083 665029006688 Domain of unknown function (DUF3413); Region: DUF3413; pfam11893 665029006689 Sulfatase; Region: Sulfatase; cl17466 665029006690 Protein of unknown function (DUF4011); Region: DUF4011; pfam13195 665029006691 Part of AAA domain; Region: AAA_19; pfam13245 665029006692 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 665029006693 AAA domain; Region: AAA_12; pfam13087 665029006694 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 665029006695 putative active site [active] 665029006696 Protein of unknown function (DUF3320); Region: DUF3320; pfam11784 665029006697 Restriction endonuclease; Region: Mrr_cat; pfam04471 665029006698 Acyltransferase family; Region: Acyl_transf_3; pfam01757 665029006699 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 665029006700 Integrase core domain; Region: rve; pfam00665 665029006701 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 665029006702 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 665029006703 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 665029006704 ABC transporter signature motif; other site 665029006705 Walker B; other site 665029006706 D-loop; other site 665029006707 H-loop/switch region; other site 665029006708 multidrug transporter membrane component/ATP-binding component; Provisional; Region: PRK10522 665029006709 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 665029006710 Walker A/P-loop; other site 665029006711 ATP binding site [chemical binding]; other site 665029006712 alpha-ketoglutarate-dependent dioxygenase AlkB; Provisional; Region: PRK15401 665029006713 ApbE family; Region: ApbE; pfam02424 665029006714 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 665029006715 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 665029006716 trimer interface [polypeptide binding]; other site 665029006717 eyelet of channel; other site 665029006718 phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional; Region: PRK10618 665029006719 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 665029006720 ATP binding site [chemical binding]; other site 665029006721 Mg2+ binding site [ion binding]; other site 665029006722 G-X-G motif; other site 665029006723 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 665029006724 putative binding surface; other site 665029006725 active site 665029006726 transcriptional regulator RcsB; Provisional; Region: PRK10840 665029006727 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 665029006728 active site 665029006729 phosphorylation site [posttranslational modification] 665029006730 intermolecular recognition site; other site 665029006731 dimerization interface [polypeptide binding]; other site 665029006732 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 665029006733 DNA binding residues [nucleotide binding] 665029006734 dimerization interface [polypeptide binding]; other site 665029006735 hybrid sensory kinase in two-component regulatory system with RcsB and YojN; Provisional; Region: PRK10841 665029006736 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 665029006737 dimer interface [polypeptide binding]; other site 665029006738 phosphorylation site [posttranslational modification] 665029006739 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 665029006740 ATP binding site [chemical binding]; other site 665029006741 Mg2+ binding site [ion binding]; other site 665029006742 G-X-G motif; other site 665029006743 RcsC Alpha-Beta-Loop (ABL); Region: RcsC; pfam09456 665029006744 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 665029006745 active site 665029006746 phosphorylation site [posttranslational modification] 665029006747 intermolecular recognition site; other site 665029006748 dimerization interface [polypeptide binding]; other site 665029006749 DNA gyrase subunit A; Validated; Region: PRK05560 665029006750 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 665029006751 CAP-like domain; other site 665029006752 active site 665029006753 primary dimer interface [polypeptide binding]; other site 665029006754 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 665029006755 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 665029006756 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 665029006757 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 665029006758 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 665029006759 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 665029006760 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 665029006761 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 665029006762 S-adenosylmethionine binding site [chemical binding]; other site 665029006763 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09103 665029006764 ATP cone domain; Region: ATP-cone; pfam03477 665029006765 Class I ribonucleotide reductase; Region: RNR_I; cd01679 665029006766 active site 665029006767 dimer interface [polypeptide binding]; other site 665029006768 catalytic residues [active] 665029006769 effector binding site; other site 665029006770 R2 peptide binding site; other site 665029006771 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 665029006772 dimer interface [polypeptide binding]; other site 665029006773 putative radical transfer pathway; other site 665029006774 diiron center [ion binding]; other site 665029006775 tyrosyl radical; other site 665029006776 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 665029006777 catalytic loop [active] 665029006778 iron binding site [ion binding]; other site 665029006779 hypothetical protein; Provisional; Region: PRK03673 665029006780 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 665029006781 putative MPT binding site; other site 665029006782 Competence-damaged protein; Region: CinA; cl00666 665029006783 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 665029006784 putative catalytic site [active] 665029006785 putative metal binding site [ion binding]; other site 665029006786 putative phosphate binding site [ion binding]; other site 665029006787 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 665029006788 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 665029006789 active site 665029006790 homotetramer interface [polypeptide binding]; other site 665029006791 potassium transport protein Kup; Provisional; Region: trkD; PRK10745 665029006792 potassium uptake protein; Region: kup; TIGR00794 665029006793 hypothetical protein; Provisional; Region: PRK10404 665029006794 Periplasmic glucans biosynthesis protein [Inorganic ion transport and metabolism]; Region: MdoG; COG3131 665029006795 glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273 665029006796 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 665029006797 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 665029006798 Coenzyme A binding pocket [chemical binding]; other site 665029006799 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 665029006800 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 665029006801 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 665029006802 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 665029006803 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 665029006804 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 665029006805 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 665029006806 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 665029006807 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 665029006808 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 665029006809 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 665029006810 4Fe-4S binding domain; Region: Fer4; pfam00037 665029006811 4Fe-4S binding domain; Region: Fer4; pfam00037 665029006812 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 665029006813 NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) [Energy production and conversion]; Region: NuoG; COG1034 665029006814 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 665029006815 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 665029006816 [4Fe-4S] binding site [ion binding]; other site 665029006817 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 665029006818 NADH dehydrogenase I subunit F; Provisional; Region: PRK11278 665029006819 SLBB domain; Region: SLBB; pfam10531 665029006820 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 665029006821 NADH dehydrogenase subunit E; Validated; Region: PRK07539 665029006822 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 665029006823 putative dimer interface [polypeptide binding]; other site 665029006824 [2Fe-2S] cluster binding site [ion binding]; other site 665029006825 bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742 665029006826 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 665029006827 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 665029006828 NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases [Energy production and conversion]; Region: NuoB; COG0377 665029006829 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 665029006830 DNA-binding transcriptional repressor LrhA; Provisional; Region: PRK15092 665029006831 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 665029006832 The C-terminal substrate domain of LysR-like regulator LrhA (LysR homologue A) and that of closely related homologs, contains the type 2 periplasmic binding fold; Region: PBP2_LrhA_like; cd08439 665029006833 putative dimerization interface [polypeptide binding]; other site 665029006834 aminotransferase AlaT; Validated; Region: PRK09265 665029006835 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 665029006836 pyridoxal 5'-phosphate binding site [chemical binding]; other site 665029006837 homodimer interface [polypeptide binding]; other site 665029006838 catalytic residue [active] 665029006839 5'-nucleotidase; Provisional; Region: PRK03826 665029006840 VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of...; Region: VIP2; cl00173 665029006841 active site 665029006842 conformational flexibility of ligand binding pocket; other site 665029006843 ADP-ribosylating toxin turn-turn motif; other site 665029006844 VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of...; Region: VIP2; cl00173 665029006845 active site 665029006846 conformational flexibility of ligand binding pocket; other site 665029006847 ADP-ribosylating toxin turn-turn motif; other site 665029006848 putative phosphatase; Provisional; Region: PRK11587 665029006849 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 665029006850 motif II; other site 665029006851 hypothetical protein; Provisional; Region: PRK01816 665029006852 propionate/acetate kinase; Provisional; Region: PRK12379 665029006853 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 665029006854 phosphate acetyltransferase; Reviewed; Region: PRK05632 665029006855 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 665029006856 DRTGG domain; Region: DRTGG; pfam07085 665029006857 phosphate acetyltransferase; Region: pta; TIGR00651 665029006858 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 665029006859 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 665029006860 Walker A/P-loop; other site 665029006861 ATP binding site [chemical binding]; other site 665029006862 Q-loop/lid; other site 665029006863 ABC transporter signature motif; other site 665029006864 Walker B; other site 665029006865 D-loop; other site 665029006866 H-loop/switch region; other site 665029006867 TOBE domain; Region: TOBE_2; pfam08402 665029006868 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 665029006869 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 665029006870 DNA-binding site [nucleotide binding]; DNA binding site 665029006871 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 665029006872 pyridoxal 5'-phosphate binding site [chemical binding]; other site 665029006873 homodimer interface [polypeptide binding]; other site 665029006874 catalytic residue [active] 665029006875 4-aminobutyrate aminotransferase; Provisional; Region: PRK06777 665029006876 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 665029006877 inhibitor-cofactor binding pocket; inhibition site 665029006878 pyridoxal 5'-phosphate binding site [chemical binding]; other site 665029006879 catalytic residue [active] 665029006880 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 665029006881 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 665029006882 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 665029006883 dimer interface [polypeptide binding]; other site 665029006884 conserved gate region; other site 665029006885 putative PBP binding loops; other site 665029006886 ABC-ATPase subunit interface; other site 665029006887 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 665029006888 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 665029006889 dimer interface [polypeptide binding]; other site 665029006890 conserved gate region; other site 665029006891 putative PBP binding loops; other site 665029006892 ABC-ATPase subunit interface; other site 665029006893 NUDIX hydrolase YfcD; Provisional; Region: PRK15393 665029006894 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 665029006895 nudix motif; other site 665029006896 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 665029006897 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 665029006898 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 665029006899 putative NAD(P) binding site [chemical binding]; other site 665029006900 putative active site [active] 665029006901 histidine/lysine/arginine/ornithine transporter subunit; Provisional; Region: PRK10619 665029006902 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 665029006903 Walker A/P-loop; other site 665029006904 ATP binding site [chemical binding]; other site 665029006905 Q-loop/lid; other site 665029006906 ABC transporter signature motif; other site 665029006907 Walker B; other site 665029006908 D-loop; other site 665029006909 H-loop/switch region; other site 665029006910 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 665029006911 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 665029006912 dimer interface [polypeptide binding]; other site 665029006913 conserved gate region; other site 665029006914 putative PBP binding loops; other site 665029006915 ABC-ATPase subunit interface; other site 665029006916 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 665029006917 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 665029006918 dimer interface [polypeptide binding]; other site 665029006919 conserved gate region; other site 665029006920 putative PBP binding loops; other site 665029006921 ABC-ATPase subunit interface; other site 665029006922 histidine ABC transporter substrate-binding protein HisJ; Provisional; Region: PRK15437 665029006923 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 665029006924 substrate binding pocket [chemical binding]; other site 665029006925 membrane-bound complex binding site; other site 665029006926 hinge residues; other site 665029006927 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 665029006928 Flavoprotein; Region: Flavoprotein; pfam02441 665029006929 amidophosphoribosyltransferase; Provisional; Region: PRK09246 665029006930 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 665029006931 active site 665029006932 tetramer interface [polypeptide binding]; other site 665029006933 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 665029006934 active site 665029006935 colicin V production protein; Provisional; Region: PRK10845 665029006936 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 665029006937 cell division protein DedD; Provisional; Region: PRK11633 665029006938 Sporulation related domain; Region: SPOR; pfam05036 665029006939 bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846 665029006940 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 665029006941 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 665029006942 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 665029006943 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 665029006944 hypothetical protein; Provisional; Region: PRK10847 665029006945 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 665029006946 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 665029006947 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 665029006948 dimerization interface 3.5A [polypeptide binding]; other site 665029006949 active site 665029006950 putative semialdehyde dehydrogenase; Provisional; Region: PRK08040 665029006951 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 665029006952 erythronate-4-phosphate dehydrogenase PdxB; Provisional; Region: PRK15438 665029006953 D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158 665029006954 ligand binding site [chemical binding]; other site 665029006955 NAD binding site [chemical binding]; other site 665029006956 catalytic site [active] 665029006957 homodimer interface [polypeptide binding]; other site 665029006958 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 665029006959 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 665029006960 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 665029006961 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 665029006962 EamA-like transporter family; Region: EamA; pfam00892 665029006963 EamA-like transporter family; Region: EamA; pfam00892 665029006964 flagella biosynthesis regulator; Provisional; Region: flk; PRK10715 665029006965 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 665029006966 active site residue [active] 665029006967 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 665029006968 DNA-binding site [nucleotide binding]; DNA binding site 665029006969 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 665029006970 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 665029006971 pyridoxal 5'-phosphate binding site [chemical binding]; other site 665029006972 homodimer interface [polypeptide binding]; other site 665029006973 catalytic residue [active] 665029006974 potential frameshift: common BLAST hit: gi|259907885|ref|YP_002648241.1| L-2,4-diaminobutyrate decarboxylase 665029006975 potential frameshift: common BLAST hit: gi|259907885|ref|YP_002648241.1| L-2,4-diaminobutyrate decarboxylase 665029006976 potential frameshift: common BLAST hit: gi|259907885|ref|YP_002648241.1| L-2,4-diaminobutyrate decarboxylase 665029006977 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 665029006978 catalytic residue [active] 665029006979 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 665029006980 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 665029006981 dimer interface [polypeptide binding]; other site 665029006982 active site 665029006983 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 665029006984 Uncharacterized conserved protein [Function unknown]; Region: COG4121 665029006985 YfcL protein; Region: YfcL; pfam08891 665029006986 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3101 665029006987 hypothetical protein; Provisional; Region: PRK10621 665029006988 Predicted permeases [General function prediction only]; Region: COG0730 665029006989 penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429 665029006990 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 665029006991 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 665029006992 Tetramer interface [polypeptide binding]; other site 665029006993 active site 665029006994 FMN-binding site [chemical binding]; other site 665029006995 HemK family putative methylases; Region: hemK_fam; TIGR00536 665029006996 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 665029006997 S-adenosylmethionine binding site [chemical binding]; other site 665029006998 hypothetical protein; Provisional; Region: PRK04946 665029006999 Smr domain; Region: Smr; pfam01713 665029007000 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 665029007001 catalytic core [active] 665029007002 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 665029007003 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 665029007004 substrate binding site [chemical binding]; other site 665029007005 oxyanion hole (OAH) forming residues; other site 665029007006 trimer interface [polypeptide binding]; other site 665029007007 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 665029007008 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 665029007009 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 665029007010 3-ketoacyl-CoA thiolase; Reviewed; Region: fadI; PRK08963 665029007011 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 665029007012 dimer interface [polypeptide binding]; other site 665029007013 active site 665029007014 long-chain fatty acid outer membrane transporter; Provisional; Region: PRK10716 665029007015 ABC transporter outer membrane lipoprotein; Provisional; Region: PRK15091 665029007016 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235 665029007017 cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142 665029007018 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 665029007019 binding surface 665029007020 TPR motif; other site 665029007021 Cytochrome C biogenesis protein; Region: CcmH; pfam03918 665029007022 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 665029007023 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 665029007024 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138 665029007025 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13165 665029007026 Heme exporter protein D [Intracellular trafficking and secretion]; Region: CcmD; COG3114 665029007027 heme exporter protein CcmC; Region: ccmC; TIGR01191 665029007028 heme exporter protein CcmB; Region: ccmB; TIGR01190 665029007029 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538 665029007030 Cytochrome c biogenesis ATP-binding export protein; Region: ABC_CcmA_heme_exporter; cd03231 665029007031 Walker A/P-loop; other site 665029007032 ATP binding site [chemical binding]; other site 665029007033 Q-loop/lid; other site 665029007034 ABC transporter signature motif; other site 665029007035 Walker B; other site 665029007036 D-loop; other site 665029007037 H-loop/switch region; other site 665029007038 BetR domain; Region: BetR; pfam08667 665029007039 Response regulator receiver domain; Region: Response_reg; pfam00072 665029007040 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 665029007041 active site 665029007042 phosphorylation site [posttranslational modification] 665029007043 intermolecular recognition site; other site 665029007044 dimerization interface [polypeptide binding]; other site 665029007045 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 665029007046 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 665029007047 Coenzyme A binding pocket [chemical binding]; other site 665029007048 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 665029007049 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 665029007050 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 665029007051 ATP binding site [chemical binding]; other site 665029007052 Mg2+ binding site [ion binding]; other site 665029007053 G-X-G motif; other site 665029007054 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 665029007055 Mechanosensitive ion channel; Region: MS_channel; pfam00924 665029007056 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 665029007057 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 665029007058 Outer membrane lipoprotein Slp family; Region: Slp; cl01164 665029007059 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 665029007060 Ligand Binding Site [chemical binding]; other site 665029007061 SopA-like central domain; Region: SopA; pfam13981 665029007062 SopA-like catalytic domain; Region: SopA_C; pfam13979 665029007063 aminotransferase; Validated; Region: PRK08175 665029007064 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 665029007065 pyridoxal 5'-phosphate binding site [chemical binding]; other site 665029007066 homodimer interface [polypeptide binding]; other site 665029007067 catalytic residue [active] 665029007068 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 665029007069 glucokinase; Provisional; Region: glk; PRK00292 665029007070 glucokinase, proteobacterial type; Region: glk; TIGR00749 665029007071 indolepyruvate decarboxylase, Erwinia family; Region: indolpyr_decarb; TIGR03393 665029007072 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 665029007073 dimer interface [polypeptide binding]; other site 665029007074 PYR/PP interface [polypeptide binding]; other site 665029007075 TPP binding site [chemical binding]; other site 665029007076 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 665029007077 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 665029007078 TPP-binding site [chemical binding]; other site 665029007079 dimer interface [polypeptide binding]; other site 665029007080 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 665029007081 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 665029007082 active site 665029007083 catalytic tetrad [active] 665029007084 manganese transport protein MntH; Reviewed; Region: PRK00701 665029007085 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 665029007086 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 665029007087 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 665029007088 Nucleoside recognition; Region: Gate; pfam07670 665029007089 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 665029007090 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 665029007091 Putative transcription regulator (DUF1323); Region: DUF1323; pfam07037 665029007092 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 665029007093 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 665029007094 active site 665029007095 HIGH motif; other site 665029007096 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 665029007097 active site 665029007098 KMSKS motif; other site 665029007099 Transcriptional regulator [Transcription]; Region: LysR; COG0583 665029007100 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 665029007101 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 665029007102 putative dimerization interface [polypeptide binding]; other site 665029007103 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 665029007104 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 665029007105 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3530 665029007106 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 665029007107 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 665029007108 nucleotide binding pocket [chemical binding]; other site 665029007109 K-X-D-G motif; other site 665029007110 catalytic site [active] 665029007111 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 665029007112 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 665029007113 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 665029007114 Dimer interface [polypeptide binding]; other site 665029007115 BRCT sequence motif; other site 665029007116 cell division protein ZipA; Provisional; Region: PRK03427 665029007117 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cd00231 665029007118 FtsZ protein binding site [polypeptide binding]; other site 665029007119 putative sulfate transport protein CysZ; Validated; Region: PRK04949 665029007120 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 665029007121 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 665029007122 dimer interface [polypeptide binding]; other site 665029007123 pyridoxal 5'-phosphate binding site [chemical binding]; other site 665029007124 catalytic residue [active] 665029007125 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 665029007126 dimerization domain swap beta strand [polypeptide binding]; other site 665029007127 regulatory protein interface [polypeptide binding]; other site 665029007128 active site 665029007129 regulatory phosphorylation site [posttranslational modification]; other site 665029007130 phosphoenolpyruvate-protein phosphotransferase; Provisional; Region: PRK11177 665029007131 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 665029007132 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 665029007133 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 665029007134 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 665029007135 HPr interaction site; other site 665029007136 glycerol kinase (GK) interaction site [polypeptide binding]; other site 665029007137 active site 665029007138 phosphorylation site [posttranslational modification] 665029007139 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 665029007140 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 665029007141 dimerization interface [polypeptide binding]; other site 665029007142 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 665029007143 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 665029007144 dimer interface [polypeptide binding]; other site 665029007145 phosphorylation site [posttranslational modification] 665029007146 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 665029007147 ATP binding site [chemical binding]; other site 665029007148 Mg2+ binding site [ion binding]; other site 665029007149 G-X-G motif; other site 665029007150 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 665029007151 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 665029007152 active site 665029007153 phosphorylation site [posttranslational modification] 665029007154 intermolecular recognition site; other site 665029007155 dimerization interface [polypeptide binding]; other site 665029007156 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 665029007157 DNA binding site [nucleotide binding] 665029007158 cysteine synthase B; Region: cysM; TIGR01138 665029007159 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 665029007160 dimer interface [polypeptide binding]; other site 665029007161 pyridoxal 5'-phosphate binding site [chemical binding]; other site 665029007162 catalytic residue [active] 665029007163 sulfate/thiosulfate transporter subunit; Provisional; Region: PRK10851 665029007164 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 665029007165 Walker A/P-loop; other site 665029007166 ATP binding site [chemical binding]; other site 665029007167 Q-loop/lid; other site 665029007168 ABC transporter signature motif; other site 665029007169 Walker B; other site 665029007170 D-loop; other site 665029007171 H-loop/switch region; other site 665029007172 sulfate transport protein; Provisional; Region: cysT; CHL00187 665029007173 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 665029007174 dimer interface [polypeptide binding]; other site 665029007175 conserved gate region; other site 665029007176 putative PBP binding loops; other site 665029007177 ABC-ATPase subunit interface; other site 665029007178 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 665029007179 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 665029007180 dimer interface [polypeptide binding]; other site 665029007181 conserved gate region; other site 665029007182 putative PBP binding loops; other site 665029007183 ABC-ATPase subunit interface; other site 665029007184 thiosulfate transporter subunit; Provisional; Region: PRK10852 665029007185 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 665029007186 RpoE-regulated lipoprotein; Provisional; Region: PRK10718 665029007187 Protein of unknown function (DUF1131); Region: DUF1131; pfam06572 665029007188 Protein of unknown function (DUF2919); Region: DUF2919; pfam11143 665029007189 putative acetyltransferase; Provisional; Region: PRK03624 665029007190 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 665029007191 Coenzyme A binding pocket [chemical binding]; other site 665029007192 N-acetylmuramoyl-l-alanine amidase I; Provisional; Region: PRK10319 665029007193 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 665029007194 active site 665029007195 metal binding site [ion binding]; metal-binding site 665029007196 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 665029007197 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 665029007198 transaldolase-like protein; Provisional; Region: PTZ00411 665029007199 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 665029007200 active site 665029007201 dimer interface [polypeptide binding]; other site 665029007202 catalytic residue [active] 665029007203 transketolase; Reviewed; Region: PRK12753 665029007204 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 665029007205 TPP-binding site [chemical binding]; other site 665029007206 dimer interface [polypeptide binding]; other site 665029007207 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 665029007208 PYR/PP interface [polypeptide binding]; other site 665029007209 dimer interface [polypeptide binding]; other site 665029007210 TPP binding site [chemical binding]; other site 665029007211 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 665029007212 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 665029007213 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 665029007214 dimer interface [polypeptide binding]; other site 665029007215 ADP-ribose binding site [chemical binding]; other site 665029007216 active site 665029007217 nudix motif; other site 665029007218 metal binding site [ion binding]; metal-binding site 665029007219 L-asparagine permease; Provisional; Region: PRK15049 665029007220 nitrate/nitrite sensor protein NarQ; Provisional; Region: PRK10935 665029007221 Histidine kinase; Region: HisKA_3; pfam07730 665029007222 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 665029007223 ATP binding site [chemical binding]; other site 665029007224 Mg2+ binding site [ion binding]; other site 665029007225 G-X-G motif; other site 665029007226 transcriptional regulator NarP; Provisional; Region: PRK10403 665029007227 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 665029007228 active site 665029007229 phosphorylation site [posttranslational modification] 665029007230 intermolecular recognition site; other site 665029007231 dimerization interface [polypeptide binding]; other site 665029007232 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 665029007233 DNA binding residues [nucleotide binding] 665029007234 dimerization interface [polypeptide binding]; other site 665029007235 aminoglycoside/multidrug efflux system; Provisional; Region: PRK10555 665029007236 Protein export membrane protein; Region: SecD_SecF; cl14618 665029007237 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 665029007238 ArsC family; Region: ArsC; pfam03960 665029007239 putative catalytic residues [active] 665029007240 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 665029007241 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 665029007242 metal binding site [ion binding]; metal-binding site 665029007243 dimer interface [polypeptide binding]; other site 665029007244 hypothetical protein; Provisional; Region: PRK13664 665029007245 Condensation domain; Region: Condensation; pfam00668 665029007246 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 665029007247 C-terminal subdomain of the Formyltransferase-like domain found in OzmH-like proteins; Region: FMT_C_OzmH_like; cd08700 665029007248 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 665029007249 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 665029007250 acyl-activating enzyme (AAE) consensus motif; other site 665029007251 AMP binding site [chemical binding]; other site 665029007252 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 665029007253 Condensation domain; Region: Condensation; pfam00668 665029007254 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 665029007255 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 665029007256 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 665029007257 acyl-activating enzyme (AAE) consensus motif; other site 665029007258 AMP binding site [chemical binding]; other site 665029007259 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 665029007260 Condensation domain; Region: Condensation; pfam00668 665029007261 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 665029007262 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 665029007263 acyl-activating enzyme (AAE) consensus motif; other site 665029007264 AMP binding site [chemical binding]; other site 665029007265 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 665029007266 Condensation domain; Region: Condensation; pfam00668 665029007267 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 665029007268 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 665029007269 acyl-activating enzyme (AAE) consensus motif; other site 665029007270 AMP binding site [chemical binding]; other site 665029007271 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 665029007272 Condensation domain; Region: Condensation; pfam00668 665029007273 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 665029007274 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 665029007275 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 665029007276 acyl-activating enzyme (AAE) consensus motif; other site 665029007277 AMP binding site [chemical binding]; other site 665029007278 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 665029007279 Condensation domain; Region: Condensation; pfam00668 665029007280 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 665029007281 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 665029007282 acyl-activating enzyme (AAE) consensus motif; other site 665029007283 AMP binding site [chemical binding]; other site 665029007284 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 665029007285 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 665029007286 Domain of unknown function (DUF1795); Region: DUF1795; pfam08786 665029007287 PAAR motif; Region: PAAR_motif; pfam05488 665029007288 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 665029007289 RHS Repeat; Region: RHS_repeat; cl11982 665029007290 RHS Repeat; Region: RHS_repeat; pfam05593 665029007291 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 665029007292 RHS Repeat; Region: RHS_repeat; pfam05593 665029007293 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 665029007294 RHS Repeat; Region: RHS_repeat; cl11982 665029007295 RHS protein; Region: RHS; pfam03527 665029007296 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 665029007297 DNase/tRNase domain of colicin-like bacteriocin; Region: Colicin-DNase; pfam12639 665029007298 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 665029007299 RHS protein; Region: RHS; pfam03527 665029007300 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 665029007301 Toxin SymE, type I toxin-antitoxin system; Region: SymE_toxin; cl07446 665029007302 Predicted P-loop ATPase fused to an acetyltransferase [General function prediction only]; Region: COG1444 665029007303 Domain of unknown function (DUF1726); Region: DUF1726; pfam08351 665029007304 Helicase; Region: Helicase_RecD; pfam05127 665029007305 GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718 665029007306 Possible tRNA binding domain; Region: tRNA_bind_2; pfam13725 665029007307 Predicted metalloprotease [General function prediction only]; Region: COG2321 665029007308 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 665029007309 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 665029007310 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 665029007311 ATP binding site [chemical binding]; other site 665029007312 active site 665029007313 substrate binding site [chemical binding]; other site 665029007314 lipoprotein; Provisional; Region: PRK11679 665029007315 NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804 665029007316 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 665029007317 dihydrodipicolinate synthase; Region: dapA; TIGR00674 665029007318 dimer interface [polypeptide binding]; other site 665029007319 active site 665029007320 catalytic residue [active] 665029007321 glycine cleavage system transcriptional repressor; Provisional; Region: gcvR; PRK11589 665029007322 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_1; cd04893 665029007323 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 665029007324 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 665029007325 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 665029007326 catalytic triad [active] 665029007327 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 665029007328 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 665029007329 metal binding site [ion binding]; metal-binding site 665029007330 active site 665029007331 I-site; other site 665029007332 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 665029007333 Peptidase family M48; Region: Peptidase_M48; pfam01435 665029007334 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 665029007335 DNA replication initiation factor; Provisional; Region: PRK08084 665029007336 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 665029007337 uracil transporter; Provisional; Region: PRK10720 665029007338 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 665029007339 active site 665029007340 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 665029007341 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 665029007342 dimerization interface [polypeptide binding]; other site 665029007343 putative ATP binding site [chemical binding]; other site 665029007344 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 665029007345 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 665029007346 active site 665029007347 substrate binding site [chemical binding]; other site 665029007348 cosubstrate binding site; other site 665029007349 catalytic site [active] 665029007350 phosphate transporter ATP-binding protein; Provisional; Region: PRK14236 665029007351 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 665029007352 Walker A/P-loop; other site 665029007353 ATP binding site [chemical binding]; other site 665029007354 Q-loop/lid; other site 665029007355 ABC transporter signature motif; other site 665029007356 Walker B; other site 665029007357 D-loop; other site 665029007358 H-loop/switch region; other site 665029007359 ABC-type phosphate transport system, auxiliary component [Inorganic ion transport and metabolism]; Region: COG4985 665029007360 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 665029007361 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 665029007362 dimer interface [polypeptide binding]; other site 665029007363 conserved gate region; other site 665029007364 putative PBP binding loops; other site 665029007365 ABC-ATPase subunit interface; other site 665029007366 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4590 665029007367 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 665029007368 conserved gate region; other site 665029007369 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 665029007370 ABC-ATPase subunit interface; other site 665029007371 polyphosphate kinase; Provisional; Region: PRK05443 665029007372 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 665029007373 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 665029007374 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 665029007375 putative active site [active] 665029007376 catalytic site [active] 665029007377 Catalytic C-terminal domain, second repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C2_like; cd09167 665029007378 domain interface [polypeptide binding]; other site 665029007379 active site 665029007380 catalytic site [active] 665029007381 exopolyphosphatase; Provisional; Region: PRK10854 665029007382 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 665029007383 nucleotide binding site [chemical binding]; other site 665029007384 tellurite resistance protein TehB; Provisional; Region: PRK11207 665029007385 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 665029007386 S-adenosylmethionine binding site [chemical binding]; other site 665029007387 MASE1; Region: MASE1; cl17823 665029007388 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 665029007389 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 665029007390 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 665029007391 MgtE intracellular N domain; Region: MgtE_N; smart00924 665029007392 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 665029007393 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 665029007394 D-galactonate transporter; Region: 2A0114; TIGR00893 665029007395 putative substrate translocation pore; other site 665029007396 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 665029007397 Escherichia coli Gne (a nucleoside-diphosphate-sugar 4-epimerase)-like, extended (e) SDRs; Region: Gne_like_SDR_e; cd05238 665029007398 putative NAD(P) binding site [chemical binding]; other site 665029007399 active site 665029007400 putative substrate binding site [chemical binding]; other site 665029007401 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 665029007402 DNA-binding site [nucleotide binding]; DNA binding site 665029007403 RNA-binding motif; other site 665029007404 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 665029007405 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 665029007406 active site 665029007407 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3122 665029007408 HTH-like domain; Region: HTH_21; pfam13276 665029007409 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 665029007410 Integrase core domain; Region: rve; pfam00665 665029007411 Integrase core domain; Region: rve_3; pfam13683 665029007412 potential frameshift: common BLAST hit: gi|110642153|ref|YP_669883.1| IS1400 transposase A 665029007413 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 665029007414 DNA-binding interface [nucleotide binding]; DNA binding site 665029007415 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 665029007416 Integrase core domain; Region: rve_3; pfam13683 665029007417 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 665029007418 Domain of unknown function (DUF4102); Region: DUF4102; pfam13356 665029007419 GMP synthase; Reviewed; Region: guaA; PRK00074 665029007420 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 665029007421 AMP/PPi binding site [chemical binding]; other site 665029007422 candidate oxyanion hole; other site 665029007423 catalytic triad [active] 665029007424 potential glutamine specificity residues [chemical binding]; other site 665029007425 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 665029007426 ATP Binding subdomain [chemical binding]; other site 665029007427 Ligand Binding sites [chemical binding]; other site 665029007428 Dimerization subdomain; other site 665029007429 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 665029007430 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 665029007431 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 665029007432 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 665029007433 active site 665029007434 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 665029007435 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 665029007436 generic binding surface II; other site 665029007437 generic binding surface I; other site 665029007438 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 665029007439 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 665029007440 active site 665029007441 Zn binding site [ion binding]; other site 665029007442 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 665029007443 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 665029007444 Trp docking motif [polypeptide binding]; other site 665029007445 putative active site [active] 665029007446 Streptomycin adenylyltransferase; Region: Adenyl_transf; pfam04439 665029007447 GTP-binding protein Der; Reviewed; Region: PRK00093 665029007448 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 665029007449 G1 box; other site 665029007450 GTP/Mg2+ binding site [chemical binding]; other site 665029007451 Switch I region; other site 665029007452 G2 box; other site 665029007453 Switch II region; other site 665029007454 G3 box; other site 665029007455 G4 box; other site 665029007456 G5 box; other site 665029007457 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 665029007458 G1 box; other site 665029007459 GTP/Mg2+ binding site [chemical binding]; other site 665029007460 Switch I region; other site 665029007461 G2 box; other site 665029007462 G3 box; other site 665029007463 Switch II region; other site 665029007464 G4 box; other site 665029007465 G5 box; other site 665029007466 outer membrane biogenesis protein BamB; Provisional; Region: PRK11138 665029007467 Beta-barrel assembly machinery (Bam) complex component B and related proteins; Region: BamB_YfgL; cd10276 665029007468 Trp docking motif [polypeptide binding]; other site 665029007469 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 665029007470 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 665029007471 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 665029007472 dimer interface [polypeptide binding]; other site 665029007473 motif 1; other site 665029007474 active site 665029007475 motif 2; other site 665029007476 motif 3; other site 665029007477 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 665029007478 anticodon binding site; other site 665029007479 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 665029007480 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 665029007481 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 665029007482 cytoskeletal protein RodZ; Provisional; Region: PRK10856 665029007483 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 665029007484 non-specific DNA binding site [nucleotide binding]; other site 665029007485 salt bridge; other site 665029007486 sequence-specific DNA binding site [nucleotide binding]; other site 665029007487 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 665029007488 type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521 665029007489 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 665029007490 binding surface 665029007491 TPR motif; other site 665029007492 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 665029007493 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 665029007494 FeS/SAM binding site; other site 665029007495 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 665029007496 active site 665029007497 multimer interface [polypeptide binding]; other site 665029007498 3-mercaptopyruvate sulfurtransferase; Provisional; Region: sseA; PRK11493 665029007499 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 665029007500 active site residue [active] 665029007501 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 665029007502 active site residue [active] 665029007503 Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055 665029007504 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 665029007505 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 665029007506 dimer interface [polypeptide binding]; other site 665029007507 NADP binding site [chemical binding]; other site 665029007508 catalytic residues [active] 665029007509 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 665029007510 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 665029007511 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 665029007512 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 665029007513 hydroxyproline-2-epimerase; Provisional; Region: PRK13970 665029007514 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 665029007515 Transcriptional regulators [Transcription]; Region: GntR; COG1802 665029007516 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 665029007517 DNA-binding site [nucleotide binding]; DNA binding site 665029007518 FCD domain; Region: FCD; pfam07729 665029007519 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 665029007520 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 665029007521 inhibitor site; inhibition site 665029007522 active site 665029007523 dimer interface [polypeptide binding]; other site 665029007524 catalytic residue [active] 665029007525 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 665029007526 enhanced serine sensitivity protein SseB; Provisional; Region: PRK11611 665029007527 aminopeptidase B; Provisional; Region: PRK05015 665029007528 Peptidase; Region: DUF3663; pfam12404 665029007529 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 665029007530 interface (dimer of trimers) [polypeptide binding]; other site 665029007531 Substrate-binding/catalytic site; other site 665029007532 Zn-binding sites [ion binding]; other site 665029007533 cysteine desulfurase; Provisional; Region: PRK14012 665029007534 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 665029007535 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 665029007536 catalytic residue [active] 665029007537 DNA-binding transcriptional regulator IscR; Provisional; Region: PRK10857 665029007538 Rrf2 family protein; Region: rrf2_super; TIGR00738 665029007539 tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ; Provisional; Region: PRK15114 665029007540 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 665029007541 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 665029007542 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 665029007543 active site 665029007544 dimerization interface [polypeptide binding]; other site 665029007545 stationary phase inducible protein CsiE; Provisional; Region: PRK11564 665029007546 PRD domain; Region: PRD; pfam00874 665029007547 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 665029007548 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 665029007549 dimer interface [polypeptide binding]; other site 665029007550 active site 665029007551 glycine-pyridoxal phosphate binding site [chemical binding]; other site 665029007552 folate binding site [chemical binding]; other site 665029007553 nitrogen regulatory protein P-II 1; Provisional; Region: PRK10858 665029007554 Nitrogen regulatory protein P-II; Region: P-II; smart00938 665029007555 response regulator GlrR; Provisional; Region: PRK15115 665029007556 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 665029007557 active site 665029007558 phosphorylation site [posttranslational modification] 665029007559 intermolecular recognition site; other site 665029007560 dimerization interface [polypeptide binding]; other site 665029007561 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 665029007562 Walker A motif; other site 665029007563 ATP binding site [chemical binding]; other site 665029007564 Walker B motif; other site 665029007565 arginine finger; other site 665029007566 hypothetical protein; Provisional; Region: PRK10722 665029007567 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 665029007568 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 665029007569 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 665029007570 dimer interface [polypeptide binding]; other site 665029007571 phosphorylation site [posttranslational modification] 665029007572 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 665029007573 ATP binding site [chemical binding]; other site 665029007574 Mg2+ binding site [ion binding]; other site 665029007575 G-X-G motif; other site 665029007576 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 665029007577 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 665029007578 dimerization interface [polypeptide binding]; other site 665029007579 ATP binding site [chemical binding]; other site 665029007580 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 665029007581 dimerization interface [polypeptide binding]; other site 665029007582 ATP binding site [chemical binding]; other site 665029007583 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 665029007584 putative active site [active] 665029007585 catalytic triad [active] 665029007586 membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859 665029007587 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 665029007588 substrate binding pocket [chemical binding]; other site 665029007589 membrane-bound complex binding site; other site 665029007590 hinge residues; other site 665029007591 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 665029007592 N-acetyl-D-glucosamine binding site [chemical binding]; other site 665029007593 catalytic residue [active] 665029007594 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 665029007595 nucleoside/Zn binding site; other site 665029007596 dimer interface [polypeptide binding]; other site 665029007597 catalytic motif [active] 665029007598 hypothetical protein; Provisional; Region: PRK11590 665029007599 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 665029007600 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 665029007601 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 665029007602 putative active site [active] 665029007603 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 665029007604 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11557 665029007605 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 665029007606 putative active site [active] 665029007607 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 665029007608 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 665029007609 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 665029007610 active site 665029007611 hydrophilic channel; other site 665029007612 dimerization interface [polypeptide binding]; other site 665029007613 catalytic residues [active] 665029007614 active site lid [active] 665029007615 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 665029007616 Recombination protein O N terminal; Region: RecO_N; pfam11967 665029007617 Recombination protein O C terminal; Region: RecO_C; pfam02565 665029007618 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 665029007619 GTPase Era; Reviewed; Region: era; PRK00089 665029007620 G1 box; other site 665029007621 GTP/Mg2+ binding site [chemical binding]; other site 665029007622 Switch I region; other site 665029007623 G2 box; other site 665029007624 Switch II region; other site 665029007625 G3 box; other site 665029007626 G4 box; other site 665029007627 G5 box; other site 665029007628 KH domain; Region: KH_2; pfam07650 665029007629 ribonuclease III; Reviewed; Region: rnc; PRK00102 665029007630 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 665029007631 dimerization interface [polypeptide binding]; other site 665029007632 active site 665029007633 metal binding site [ion binding]; metal-binding site 665029007634 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 665029007635 dsRNA binding site [nucleotide binding]; other site 665029007636 signal peptidase I; Provisional; Region: PRK10861 665029007637 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 665029007638 Catalytic site [active] 665029007639 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 665029007640 GTP-binding protein LepA; Provisional; Region: PRK05433 665029007641 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 665029007642 G1 box; other site 665029007643 putative GEF interaction site [polypeptide binding]; other site 665029007644 GTP/Mg2+ binding site [chemical binding]; other site 665029007645 Switch I region; other site 665029007646 G2 box; other site 665029007647 G3 box; other site 665029007648 Switch II region; other site 665029007649 G4 box; other site 665029007650 G5 box; other site 665029007651 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 665029007652 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 665029007653 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 665029007654 Antitermination protein; Region: Antiterm; pfam03589 665029007655 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 665029007656 SoxR reducing system protein RseC; Provisional; Region: PRK10862 665029007657 anti-sigma E factor; Provisional; Region: rseB; PRK09455 665029007658 Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026 665029007659 anti-RNA polymerase sigma factor SigE; Provisional; Region: PRK10863 665029007660 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 665029007661 Anti sigma-E protein RseA, C-terminal domain; Region: RseA_C; pfam03873 665029007662 RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939 665029007663 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 665029007664 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 665029007665 DNA binding residues [nucleotide binding] 665029007666 L-aspartate oxidase; Provisional; Region: PRK06175 665029007667 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 665029007668 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 665029007669 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 665029007670 S-adenosylmethionine binding site [chemical binding]; other site 665029007671 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 665029007672 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 665029007673 ATP binding site [chemical binding]; other site 665029007674 Mg++ binding site [ion binding]; other site 665029007675 motif III; other site 665029007676 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 665029007677 nucleotide binding region [chemical binding]; other site 665029007678 ATP-binding site [chemical binding]; other site 665029007679 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 665029007680 ligand binding site [chemical binding]; other site 665029007681 active site 665029007682 UGI interface [polypeptide binding]; other site 665029007683 catalytic site [active] 665029007684 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 665029007685 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 665029007686 dimer interface [polypeptide binding]; other site 665029007687 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 665029007688 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03378 665029007689 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 665029007690 recombination and repair protein; Provisional; Region: PRK10869 665029007691 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 665029007692 Walker A/P-loop; other site 665029007693 ATP binding site [chemical binding]; other site 665029007694 Q-loop/lid; other site 665029007695 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 665029007696 ABC transporter signature motif; other site 665029007697 Walker B; other site 665029007698 D-loop; other site 665029007699 H-loop/switch region; other site 665029007700 outer membrane biogenesis protein BamE; Provisional; Region: PRK11548 665029007701 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 665029007702 hypothetical protein; Validated; Region: PRK01777 665029007703 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 665029007704 putative coenzyme Q binding site [chemical binding]; other site 665029007705 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 665029007706 SmpB-tmRNA interface; other site 665029007707 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 665029007708 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsC; COG3563 665029007709 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 665029007710 putative CheA interaction surface; other site 665029007711 chemotaxis protein CheA; Provisional; Region: PRK10547 665029007712 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 665029007713 putative binding surface; other site 665029007714 active site 665029007715 CheY binding; Region: CheY-binding; pfam09078 665029007716 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 665029007717 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 665029007718 ATP binding site [chemical binding]; other site 665029007719 Mg2+ binding site [ion binding]; other site 665029007720 G-X-G motif; other site 665029007721 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 665029007722 flagellar motor protein MotB; Validated; Region: motB; PRK09041 665029007723 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 665029007724 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 665029007725 ligand binding site [chemical binding]; other site 665029007726 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 665029007727 flagellar motor protein MotA; Validated; Region: PRK09110 665029007728 transcriptional activator FlhC; Provisional; Region: PRK12722 665029007729 transcriptional activator FlhD; Provisional; Region: PRK02909 665029007730 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 665029007731 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 665029007732 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 665029007733 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 665029007734 DNA binding residues [nucleotide binding] 665029007735 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 665029007736 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 665029007737 dimerization interface [polypeptide binding]; other site 665029007738 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 665029007739 dimer interface [polypeptide binding]; other site 665029007740 putative CheW interface [polypeptide binding]; other site 665029007741 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08027 665029007742 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 665029007743 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK08147 665029007744 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 665029007745 flagellar rod assembly protein/muramidase FlgJ; Validated; Region: flgJ; PRK05684 665029007746 Rod binding protein [Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3951 665029007747 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 665029007748 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 665029007749 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 665029007750 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 665029007751 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK12696 665029007752 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 665029007753 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 665029007754 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 665029007755 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640 665029007756 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 665029007757 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 665029007758 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 665029007759 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 665029007760 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 665029007761 Flagellar hook capping protein [Cell motility and secretion]; Region: FlgD; COG1843 665029007762 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 665029007763 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 665029007764 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 665029007765 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 665029007766 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 665029007767 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 665029007768 SAF-like; Region: SAF_2; pfam13144 665029007769 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 665029007770 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 665029007771 flagellar biosynthesis anti-sigma factor FlgM; Region: FlgM_jcvi; TIGR03824 665029007772 FlgN protein; Region: FlgN; cl09176 665029007773 Flagellar protein FliT; Region: FliT; pfam05400 665029007774 Flagellar protein FliS; Region: FliS; cl00654 665029007775 flagellar capping protein; Reviewed; Region: fliD; PRK08032 665029007776 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 665029007777 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 665029007778 flagellin; Validated; Region: PRK08026 665029007779 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 665029007780 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 665029007781 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 665029007782 DNA binding site [nucleotide binding] 665029007783 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 665029007784 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 665029007785 putative CoA binding site [chemical binding]; other site 665029007786 putative trimer interface [polypeptide binding]; other site 665029007787 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 665029007788 trimer interface [polypeptide binding]; other site 665029007789 active site 665029007790 substrate binding site [chemical binding]; other site 665029007791 CoA binding site [chemical binding]; other site 665029007792 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 665029007793 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 665029007794 inhibitor-cofactor binding pocket; inhibition site 665029007795 pyridoxal 5'-phosphate binding site [chemical binding]; other site 665029007796 catalytic residue [active] 665029007797 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 665029007798 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 665029007799 S-adenosylmethionine binding site [chemical binding]; other site 665029007800 Predicted methyltransferase regulatory domain; Region: MethyTransf_Reg; pfam10119 665029007801 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 665029007802 TPR motif; other site 665029007803 binding surface 665029007804 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 665029007805 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 665029007806 Bacterial export proteins, family 3; Region: Bac_export_3; cl00867 665029007807 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 665029007808 Flagellar biosynthesis protein, FliO; Region: FliO; cl01247 665029007809 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 665029007810 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 665029007811 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 665029007812 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07021 665029007813 Flagellar hook-length control protein FliK; Region: Flg_hook; cl17777 665029007814 Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882 665029007815 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689 665029007816 flagellum-specific ATP synthase; Validated; Region: fliI; PRK07960 665029007817 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 665029007818 Walker A motif/ATP binding site; other site 665029007819 Walker B motif; other site 665029007820 flagellar assembly protein H; Validated; Region: fliH; PRK05687 665029007821 Essential protein Yae1, N terminal; Region: Yae1_N; pfam09811 665029007822 Flagellar assembly protein FliH; Region: FliH; pfam02108 665029007823 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 665029007824 FliG C-terminal domain; Region: FliG_C; pfam01706 665029007825 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 665029007826 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514 665029007827 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 665029007828 Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139 665029007829 chemotaxis methyltransferase CheR; Provisional; Region: PRK10611 665029007830 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 665029007831 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 665029007832 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 665029007833 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 665029007834 active site 665029007835 phosphorylation site [posttranslational modification] 665029007836 intermolecular recognition site; other site 665029007837 dimerization interface [polypeptide binding]; other site 665029007838 CheB methylesterase; Region: CheB_methylest; pfam01339 665029007839 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 665029007840 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 665029007841 active site 665029007842 phosphorylation site [posttranslational modification] 665029007843 intermolecular recognition site; other site 665029007844 dimerization interface [polypeptide binding]; other site 665029007845 Chemotaxis phosphatase, CheZ; Region: CheZ; cl01219 665029007846 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 665029007847 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 665029007848 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 665029007849 FHIPEP family; Region: FHIPEP; pfam00771 665029007850 Flagellar protein FlhE; Region: FlhE; pfam06366 665029007851 nucleoside-specific channel-forming protein Tsx; Provisional; Region: PRK15106 665029007852 spermidine N1-acetyltransferase; Provisional; Region: PRK15130 665029007853 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 665029007854 Coenzyme A binding pocket [chemical binding]; other site 665029007855 hypothetical protein; Provisional; Region: PRK10556 665029007856 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 665029007857 catalytic residues [active] 665029007858 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 665029007859 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 665029007860 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 665029007861 Class I ribonucleotide reductase; Region: RNR_I; cd01679 665029007862 active site 665029007863 dimer interface [polypeptide binding]; other site 665029007864 catalytic residues [active] 665029007865 effector binding site; other site 665029007866 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 665029007867 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 665029007868 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 665029007869 dimer interface [polypeptide binding]; other site 665029007870 putative radical transfer pathway; other site 665029007871 diiron center [ion binding]; other site 665029007872 tyrosyl radical; other site 665029007873 glycine betaine transporter ATP-binding subunit; Provisional; Region: PRK10070 665029007874 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 665029007875 Walker A/P-loop; other site 665029007876 ATP binding site [chemical binding]; other site 665029007877 Q-loop/lid; other site 665029007878 ABC transporter signature motif; other site 665029007879 Walker B; other site 665029007880 D-loop; other site 665029007881 H-loop/switch region; other site 665029007882 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 665029007883 glycine betaine transporter membrane protein; Provisional; Region: PRK10952 665029007884 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 665029007885 dimer interface [polypeptide binding]; other site 665029007886 conserved gate region; other site 665029007887 putative PBP binding loops; other site 665029007888 ABC-ATPase subunit interface; other site 665029007889 glycine betaine transporter periplasmic subunit; Provisional; Region: proX; PRK11119 665029007890 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 665029007891 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 665029007892 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 665029007893 transcriptional repressor MprA; Provisional; Region: PRK10870 665029007894 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 665029007895 multidrug efflux system protein EmrA; Provisional; Region: PRK15136 665029007896 ATP P2X receptor; Region: P2X_receptor; cl02993 665029007897 HlyD family secretion protein; Region: HlyD_3; pfam13437 665029007898 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 665029007899 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 665029007900 putative substrate translocation pore; other site 665029007901 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 665029007902 putative methyltransferase; Provisional; Region: PRK10864 665029007903 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 665029007904 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 665029007905 thioredoxin 2; Provisional; Region: PRK10996 665029007906 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 665029007907 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 665029007908 catalytic residues [active] 665029007909 Uncharacterized conserved protein [Function unknown]; Region: COG3148 665029007910 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 665029007911 CoA binding domain; Region: CoA_binding_2; pfam13380 665029007912 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 665029007913 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 665029007914 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 665029007915 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 665029007916 phosphatidylserine synthase; Provisional; Region: pssA; PRK09428 665029007917 Catalytic domain, repeat 1, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_1; cd09134 665029007918 domain interface [polypeptide binding]; other site 665029007919 putative active site [active] 665029007920 catalytic site [active] 665029007921 Catalytic domain, repeat 2, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_2; cd09136 665029007922 domain interface [polypeptide binding]; other site 665029007923 putative active site [active] 665029007924 catalytic site [active] 665029007925 lipoprotein; Provisional; Region: PRK10759 665029007926 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 665029007927 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 665029007928 putative substrate translocation pore; other site 665029007929 D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942 665029007930 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 665029007931 active site 665029007932 motif I; other site 665029007933 motif II; other site 665029007934 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 665029007935 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 665029007936 Walker A/P-loop; other site 665029007937 ATP binding site [chemical binding]; other site 665029007938 Q-loop/lid; other site 665029007939 ABC transporter signature motif; other site 665029007940 Walker B; other site 665029007941 D-loop; other site 665029007942 H-loop/switch region; other site 665029007943 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 665029007944 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 665029007945 dimer interface [polypeptide binding]; other site 665029007946 conserved gate region; other site 665029007947 ABC-ATPase subunit interface; other site 665029007948 DL-methionine transporter substrate-binding subunit; Provisional; Region: metQ; PRK11063 665029007949 lipoprotein, YaeC family; Region: TIGR00363 665029007950 outer membrane lipoprotein; Reviewed; Region: rcsF; PRK10781 665029007951 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 665029007952 homodimer interaction site [polypeptide binding]; other site 665029007953 cofactor binding site; other site 665029007954 prolyl-tRNA synthetase; Provisional; Region: PRK09194 665029007955 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 665029007956 dimer interface [polypeptide binding]; other site 665029007957 motif 1; other site 665029007958 active site 665029007959 motif 2; other site 665029007960 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 665029007961 putative deacylase active site [active] 665029007962 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 665029007963 active site 665029007964 motif 3; other site 665029007965 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 665029007966 anticodon binding site; other site 665029007967 hypothetical protein; Provisional; Region: PRK09256 665029007968 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 665029007969 YaeQ protein; Region: YaeQ; pfam07152 665029007970 Modulator of Rho-dependent transcription termination (ROF); Region: ROF; cl09210 665029007971 tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660 665029007972 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 665029007973 Ligand Binding Site [chemical binding]; other site 665029007974 TilS substrate binding domain; Region: TilS; pfam09179 665029007975 TilS substrate C-terminal domain; Region: TilS_C; pfam11734 665029007976 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 665029007977 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 665029007978 putative metal binding site [ion binding]; other site 665029007979 lysine decarboxylase LdcC; Provisional; Region: PRK15399 665029007980 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 665029007981 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 665029007982 homodimer interface [polypeptide binding]; other site 665029007983 pyridoxal 5'-phosphate binding site [chemical binding]; other site 665029007984 catalytic residue [active] 665029007985 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 665029007986 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 665029007987 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 665029007988 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 665029007989 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 665029007990 putative active site [active] 665029007991 putative PHP Thumb interface [polypeptide binding]; other site 665029007992 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 665029007993 generic binding surface II; other site 665029007994 generic binding surface I; other site 665029007995 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 665029007996 RNA/DNA hybrid binding site [nucleotide binding]; other site 665029007997 active site 665029007998 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 665029007999 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 665029008000 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 665029008001 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 665029008002 active site 665029008003 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 665029008004 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 665029008005 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 665029008006 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 665029008007 trimer interface [polypeptide binding]; other site 665029008008 active site 665029008009 UDP-GlcNAc binding site [chemical binding]; other site 665029008010 lipid binding site [chemical binding]; lipid-binding site 665029008011 periplasmic chaperone; Provisional; Region: PRK10780 665029008012 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 665029008013 outer membrane protein assembly factor YaeT; Provisional; Region: PRK11067 665029008014 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 665029008015 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 665029008016 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 665029008017 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 665029008018 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 665029008019 Surface antigen; Region: Bac_surface_Ag; pfam01103 665029008020 zinc metallopeptidase RseP; Provisional; Region: PRK10779 665029008021 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 665029008022 active site 665029008023 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 665029008024 protein binding site [polypeptide binding]; other site 665029008025 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 665029008026 protein binding site [polypeptide binding]; other site 665029008027 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 665029008028 putative substrate binding region [chemical binding]; other site 665029008029 CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624 665029008030 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 665029008031 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 665029008032 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 665029008033 catalytic residue [active] 665029008034 putative FPP diphosphate binding site; other site 665029008035 putative FPP binding hydrophobic cleft; other site 665029008036 dimer interface [polypeptide binding]; other site 665029008037 putative IPP diphosphate binding site; other site 665029008038 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 665029008039 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 665029008040 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 665029008041 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 665029008042 ribosome recycling factor; Reviewed; Region: frr; PRK00083 665029008043 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 665029008044 hinge region; other site 665029008045 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 665029008046 putative nucleotide binding site [chemical binding]; other site 665029008047 uridine monophosphate binding site [chemical binding]; other site 665029008048 homohexameric interface [polypeptide binding]; other site 665029008049 elongation factor Ts; Provisional; Region: tsf; PRK09377 665029008050 UBA/TS-N domain; Region: UBA; pfam00627 665029008051 Elongation factor TS; Region: EF_TS; pfam00889 665029008052 Elongation factor TS; Region: EF_TS; pfam00889 665029008053 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 665029008054 rRNA interaction site [nucleotide binding]; other site 665029008055 S8 interaction site; other site 665029008056 putative laminin-1 binding site; other site 665029008057 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 665029008058 active site 665029008059 PII uridylyl-transferase; Provisional; Region: PRK05007 665029008060 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 665029008061 metal binding triad; other site 665029008062 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 665029008063 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 665029008064 Zn2+ binding site [ion binding]; other site 665029008065 Mg2+ binding site [ion binding]; other site 665029008066 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 665029008067 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 665029008068 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 665029008069 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 665029008070 trimer interface [polypeptide binding]; other site 665029008071 active site 665029008072 substrate binding site [chemical binding]; other site 665029008073 CoA binding site [chemical binding]; other site 665029008074 hypothetical protein; Provisional; Region: PRK13677 665029008075 serine endoprotease; Provisional; Region: PRK10942 665029008076 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 665029008077 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 665029008078 protein binding site [polypeptide binding]; other site 665029008079 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 665029008080 deoxyguanosinetriphosphate triphosphohydrolase; Provisional; Region: dgt; PRK04926 665029008081 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 665029008082 Zn2+ binding site [ion binding]; other site 665029008083 Mg2+ binding site [ion binding]; other site 665029008084 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 665029008085 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 665029008086 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 665029008087 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 665029008088 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 665029008089 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 665029008090 inhibitor-cofactor binding pocket; inhibition site 665029008091 pyridoxal 5'-phosphate binding site [chemical binding]; other site 665029008092 catalytic residue [active] 665029008093 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 665029008094 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 665029008095 ABC-ATPase subunit interface; other site 665029008096 dimer interface [polypeptide binding]; other site 665029008097 putative PBP binding regions; other site 665029008098 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 665029008099 ABC-ATPase subunit interface; other site 665029008100 dimer interface [polypeptide binding]; other site 665029008101 putative PBP binding regions; other site 665029008102 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 665029008103 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 665029008104 siderophore binding site; other site 665029008105 iron-hydroxamate transporter ATP-binding subunit; Provisional; Region: PRK10575 665029008106 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 665029008107 Walker A/P-loop; other site 665029008108 ATP binding site [chemical binding]; other site 665029008109 Q-loop/lid; other site 665029008110 ABC transporter signature motif; other site 665029008111 Walker B; other site 665029008112 D-loop; other site 665029008113 H-loop/switch region; other site 665029008114 potential frameshift: common BLAST hit: gi|188533022|ref|YP_001906819.1| ferrichrome outer membrane transporter 665029008115 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 665029008116 potential frameshift: common BLAST hit: gi|188533022|ref|YP_001906819.1| ferrichrome outer membrane transporter 665029008117 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 665029008118 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 665029008119 N-terminal plug; other site 665029008120 ligand-binding site [chemical binding]; other site 665029008121 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl17483 665029008122 bifunctional antitoxin/transcriptional repressor RelB; Provisional; Region: PRK11235 665029008123 Toxin SymE, type I toxin-antitoxin system; Region: SymE_toxin; cl07446 665029008124 PAAR motif; Region: PAAR_motif; pfam05488 665029008125 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 665029008126 RHS Repeat; Region: RHS_repeat; cl11982 665029008127 RHS Repeat; Region: RHS_repeat; pfam05593 665029008128 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 665029008129 RHS Repeat; Region: RHS_repeat; pfam05593 665029008130 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 665029008131 RHS Repeat; Region: RHS_repeat; cl11982 665029008132 RHS protein; Region: RHS; pfam03527 665029008133 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 665029008134 Domain of unknown function (DUF1795); Region: DUF1795; pfam08786 665029008135 bifunctional glycosyl transferase/transpeptidase; Reviewed; Region: mrcB; PRK09506 665029008136 Transglycosylase; Region: Transgly; pfam00912 665029008137 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 665029008138 ATP-dependent RNA helicase HrpB; Provisional; Region: PRK11664 665029008139 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 665029008140 ATP binding site [chemical binding]; other site 665029008141 putative Mg++ binding site [ion binding]; other site 665029008142 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 665029008143 nucleotide binding region [chemical binding]; other site 665029008144 ATP-binding site [chemical binding]; other site 665029008145 Helicase associated domain (HA2) Add an annotation; Region: HA2; smart00847 665029008146 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 665029008147 2'-5' RNA ligase; Provisional; Region: PRK15124 665029008148 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 665029008149 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 665029008150 RNA polymerase-binding transcription factor; Provisional; Region: dksA; PRK10778 665029008151 Glutamyl- and glutaminyl-tRNA synthetases [Translation, ribosomal structure and biogenesis]; Region: GlnS; COG0008 665029008152 glutamyl-queuosine tRNA(Asp) synthetase; Region: queuosine_YadB; TIGR03838 665029008153 active site 665029008154 nucleotide binding site [chemical binding]; other site 665029008155 HIGH motif; other site 665029008156 KMSKS motif; other site 665029008157 poly(A) polymerase I; Provisional; Region: pcnB; PRK11623 665029008158 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 665029008159 active site 665029008160 NTP binding site [chemical binding]; other site 665029008161 metal binding triad [ion binding]; metal-binding site 665029008162 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 665029008163 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 665029008164 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 665029008165 catalytic center binding site [active] 665029008166 ATP binding site [chemical binding]; other site 665029008167 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 665029008168 oligomerization interface [polypeptide binding]; other site 665029008169 active site 665029008170 metal binding site [ion binding]; metal-binding site 665029008171 Pantoate-beta-alanine ligase; Region: PanC; cd00560 665029008172 pantoate--beta-alanine ligase; Region: panC; TIGR00018 665029008173 active site 665029008174 ATP-binding site [chemical binding]; other site 665029008175 pantoate-binding site; other site 665029008176 HXXH motif; other site 665029008177 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 665029008178 tetramerization interface [polypeptide binding]; other site 665029008179 active site 665029008180 inner membrane transport permease; Provisional; Region: PRK15066 665029008181 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 665029008182 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 665029008183 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 665029008184 Walker A/P-loop; other site 665029008185 ATP binding site [chemical binding]; other site 665029008186 Q-loop/lid; other site 665029008187 ABC transporter signature motif; other site 665029008188 Walker B; other site 665029008189 D-loop; other site 665029008190 H-loop/switch region; other site 665029008191 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 665029008192 active site clefts [active] 665029008193 zinc binding site [ion binding]; other site 665029008194 dimer interface [polypeptide binding]; other site 665029008195 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 665029008196 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 665029008197 active site 665029008198 methionine gamma-lyase; Validated; Region: PRK07049 665029008199 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 665029008200 homodimer interface [polypeptide binding]; other site 665029008201 substrate-cofactor binding pocket; other site 665029008202 pyridoxal 5'-phosphate binding site [chemical binding]; other site 665029008203 catalytic residue [active] 665029008204 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 665029008205 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 665029008206 DNA binding residues [nucleotide binding] 665029008207 dimerization interface [polypeptide binding]; other site 665029008208 multicopper oxidase; Provisional; Region: PRK10965 665029008209 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 665029008210 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 665029008211 Bacterial chaperone lipoprotein (PulS_OutS); Region: PulS_OutS; cl09898 665029008212 spermidine synthase; Provisional; Region: PRK00811 665029008213 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 665029008214 S-adenosylmethionine binding site [chemical binding]; other site 665029008215 S-adenosylmethionine decarboxylase; Provisional; Region: PRK05462 665029008216 hypothetical protein; Provisional; Region: PRK05248 665029008217 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 665029008218 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 665029008219 substrate binding site [chemical binding]; other site 665029008220 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 665029008221 substrate binding site [chemical binding]; other site 665029008222 ligand binding site [chemical binding]; other site 665029008223 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 665029008224 DNA binding site [nucleotide binding] 665029008225 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I-E; cd09648 665029008226 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-E; cd09719 665029008227 CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cd09727 665029008228 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 665029008229 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cd09645 665029008230 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-E; cl09608 665029008231 CRISPR/Cas system-associated protein Cse2; Region: Cse2_I-E; cd09670 665029008232 Cascade antiviral complex protein; Validated; Region: PRK09693 665029008233 helicase Cas3; Provisional; Region: PRK09694 665029008234 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 665029008235 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 665029008236 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 665029008237 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 665029008238 active site 665029008239 iron coordination sites [ion binding]; other site 665029008240 substrate binding pocket [chemical binding]; other site 665029008241 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 665029008242 Coenzyme A binding pocket [chemical binding]; other site 665029008243 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 665029008244 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 665029008245 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 665029008246 substrate binding site [chemical binding]; other site 665029008247 oxyanion hole (OAH) forming residues; other site 665029008248 trimer interface [polypeptide binding]; other site 665029008249 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 665029008250 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 665029008251 dimer interface [polypeptide binding]; other site 665029008252 active site 665029008253 acyl-CoA synthetase; Validated; Region: PRK07638 665029008254 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 665029008255 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 665029008256 acyl-activating enzyme (AAE) consensus motif; other site 665029008257 acyl-activating enzyme (AAE) consensus motif; other site 665029008258 AMP binding site [chemical binding]; other site 665029008259 active site 665029008260 CoA binding site [chemical binding]; other site 665029008261 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 665029008262 active site 665029008263 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 665029008264 2-enoyl thioester reductase-like; Region: ETR_like; cd05282 665029008265 NADP binding site [chemical binding]; other site 665029008266 dimer interface [polypeptide binding]; other site 665029008267 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 665029008268 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 665029008269 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 665029008270 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 665029008271 Walker A/P-loop; other site 665029008272 ATP binding site [chemical binding]; other site 665029008273 Q-loop/lid; other site 665029008274 ABC transporter signature motif; other site 665029008275 Walker B; other site 665029008276 D-loop; other site 665029008277 H-loop/switch region; other site 665029008278 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 665029008279 classical (c) SDRs; Region: SDR_c; cd05233 665029008280 NAD(P) binding site [chemical binding]; other site 665029008281 active site 665029008282 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 665029008283 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 665029008284 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 665029008285 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 665029008286 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 665029008287 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 665029008288 E3 interaction surface; other site 665029008289 lipoyl attachment site [posttranslational modification]; other site 665029008290 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 665029008291 E3 interaction surface; other site 665029008292 lipoyl attachment site [posttranslational modification]; other site 665029008293 e3 binding domain; Region: E3_binding; pfam02817 665029008294 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 665029008295 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 665029008296 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 665029008297 dimer interface [polypeptide binding]; other site 665029008298 TPP-binding site [chemical binding]; other site 665029008299 transcriptional regulator PdhR; Reviewed; Region: pdhR; PRK09464 665029008300 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 665029008301 DNA-binding site [nucleotide binding]; DNA binding site 665029008302 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 665029008303 aromatic amino acid transporter; Provisional; Region: PRK10238 665029008304 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 665029008305 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 665029008306 putative substrate translocation pore; other site 665029008307 Glycosyl hydrolase family 43; Region: GH43_1; cd08980 665029008308 active site 665029008309 outer membrane protease; Reviewed; Region: PRK10993 665029008310 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 665029008311 outer membrane protease; Reviewed; Region: PRK10993 665029008312 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 665029008313 regulatory protein AmpE; Provisional; Region: PRK10987 665029008314 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 665029008315 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 665029008316 amidase catalytic site [active] 665029008317 Zn binding residues [ion binding]; other site 665029008318 substrate binding site [chemical binding]; other site 665029008319 putative major pilin subunit; Provisional; Region: PRK10574 665029008320 hypothetical protein; Provisional; Region: PRK10436 665029008321 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 665029008322 Walker A motif; other site 665029008323 ATP binding site [chemical binding]; other site 665029008324 Walker B motif; other site 665029008325 type IV pilin biogenesis protein; Provisional; Region: PRK10573 665029008326 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 665029008327 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 665029008328 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05096 665029008329 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 665029008330 active site 665029008331 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 665029008332 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 665029008333 CoA-binding site [chemical binding]; other site 665029008334 ATP-binding [chemical binding]; other site 665029008335 hypothetical protein; Provisional; Region: PRK05287 665029008336 Domain of unknown function (DUF329); Region: DUF329; cl01144 665029008337 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 665029008338 active site 665029008339 8-oxo-dGMP binding site [chemical binding]; other site 665029008340 nudix motif; other site 665029008341 metal binding site [ion binding]; metal-binding site 665029008342 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 665029008343 Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356 665029008344 type II secretion system protein D; Region: type_II_gspD; TIGR02517 665029008345 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 665029008346 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 665029008347 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 665029008348 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 665029008349 type II secretion system protein E; Region: type_II_gspE; TIGR02533 665029008350 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 665029008351 Walker A motif; other site 665029008352 ATP binding site [chemical binding]; other site 665029008353 Walker B motif; other site 665029008354 type II secretion system protein F; Region: GspF; TIGR02120 665029008355 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 665029008356 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 665029008357 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 665029008358 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 665029008359 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 665029008360 type II secretion system protein I; Region: gspI; TIGR01707 665029008361 Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501 665029008362 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 665029008363 type II secretion system protein J; Region: gspJ; TIGR01711 665029008364 Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612 665029008365 Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934 665029008366 Type II secretion system (T2SS), protein L; Region: T2SL; pfam05134 665029008367 GspL periplasmic domain; Region: GspL_C; cl14909 665029008368 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 665029008369 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 665029008370 Bacterial chaperone lipoprotein (PulS_OutS); Region: PulS_OutS; cl09898 665029008371 N-acetylglucosamine-binding protein A; Reviewed; Region: PRK13211 665029008372 Chitin binding domain; Region: Chitin_bind_3; pfam03067 665029008373 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 665029008374 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 665029008375 SEC-C motif; Region: SEC-C; pfam02810 665029008376 SecA regulator SecM; Provisional; Region: PRK02943 665029008377 Protein of unknown function (DUF721); Region: DUF721; cl02324 665029008378 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 665029008379 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 665029008380 cell division protein FtsZ; Validated; Region: PRK09330 665029008381 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 665029008382 nucleotide binding site [chemical binding]; other site 665029008383 SulA interaction site; other site 665029008384 cell division protein FtsA; Reviewed; Region: ftsA; PRK09472 665029008385 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 665029008386 Cell division protein FtsA; Region: FtsA; pfam14450 665029008387 cell division protein FtsQ; Provisional; Region: PRK10775 665029008388 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 665029008389 Cell division protein FtsQ; Region: FtsQ; pfam03799 665029008390 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 665029008391 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 665029008392 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 665029008393 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 665029008394 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 665029008395 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 665029008396 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 665029008397 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 665029008398 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 665029008399 active site 665029008400 homodimer interface [polypeptide binding]; other site 665029008401 cell division protein FtsW; Provisional; Region: PRK10774 665029008402 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03806 665029008403 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 665029008404 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 665029008405 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 665029008406 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 665029008407 Mg++ binding site [ion binding]; other site 665029008408 putative catalytic motif [active] 665029008409 putative substrate binding site [chemical binding]; other site 665029008410 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed; Region: murF; PRK10773 665029008411 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 665029008412 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 665029008413 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 665029008414 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 665029008415 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 665029008416 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 665029008417 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 665029008418 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 665029008419 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 665029008420 cell division protein FtsL; Provisional; Region: PRK10772 665029008421 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 665029008422 MraW methylase family; Region: Methyltransf_5; pfam01795 665029008423 cell division protein MraZ; Reviewed; Region: PRK00326 665029008424 MraZ protein; Region: MraZ; pfam02381 665029008425 MraZ protein; Region: MraZ; pfam02381 665029008426 DNA-binding transcriptional regulator FruR; Provisional; Region: PRK11303 665029008427 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 665029008428 DNA binding site [nucleotide binding] 665029008429 domain linker motif; other site 665029008430 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 665029008431 dimerization interface [polypeptide binding]; other site 665029008432 ligand binding site [chemical binding]; other site 665029008433 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 665029008434 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 665029008435 putative valine binding site [chemical binding]; other site 665029008436 dimer interface [polypeptide binding]; other site 665029008437 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 665029008438 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK07979 665029008439 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 665029008440 PYR/PP interface [polypeptide binding]; other site 665029008441 dimer interface [polypeptide binding]; other site 665029008442 TPP binding site [chemical binding]; other site 665029008443 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 665029008444 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 665029008445 TPP-binding site [chemical binding]; other site 665029008446 dimer interface [polypeptide binding]; other site 665029008447 2-isopropylmalate synthase; Validated; Region: PRK00915 665029008448 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 665029008449 active site 665029008450 catalytic residues [active] 665029008451 metal binding site [ion binding]; metal-binding site 665029008452 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 665029008453 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 665029008454 tartrate dehydrogenase; Provisional; Region: PRK08194 665029008455 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 665029008456 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 665029008457 substrate binding site [chemical binding]; other site 665029008458 ligand binding site [chemical binding]; other site 665029008459 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 665029008460 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 665029008461 substrate binding site [chemical binding]; other site 665029008462 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 665029008463 sugar efflux transporter; Region: 2A0120; TIGR00899 665029008464 putative substrate translocation pore; other site 665029008465 transcriptional regulator SgrR; Provisional; Region: PRK13626 665029008466 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 665029008467 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 665029008468 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 665029008469 thiamine transporter substrate binding subunit; Provisional; Region: tbpA; PRK11205 665029008470 thiamine transporter membrane protein; Reviewed; Region: thiP; PRK09433 665029008471 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 665029008472 dimer interface [polypeptide binding]; other site 665029008473 conserved gate region; other site 665029008474 putative PBP binding loops; other site 665029008475 ABC-ATPase subunit interface; other site 665029008476 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 665029008477 dimer interface [polypeptide binding]; other site 665029008478 conserved gate region; other site 665029008479 putative PBP binding loops; other site 665029008480 ABC-ATPase subunit interface; other site 665029008481 thiamine transporter ATP-binding subunit; Provisional; Region: thiQ; PRK10771 665029008482 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 665029008483 Walker A/P-loop; other site 665029008484 ATP binding site [chemical binding]; other site 665029008485 Q-loop/lid; other site 665029008486 ABC transporter signature motif; other site 665029008487 Walker B; other site 665029008488 D-loop; other site 665029008489 H-loop/switch region; other site 665029008490 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 665029008491 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 665029008492 DNA polymerase II; Reviewed; Region: PRK05762 665029008493 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase II and similar bacterial family-B DNA polymerases; Region: DNA_polB_II_exo; cd05784 665029008494 active site 665029008495 catalytic site [active] 665029008496 substrate binding site [chemical binding]; other site 665029008497 DNA polymerase type-II subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II; cd05537 665029008498 active site 665029008499 metal-binding site 665029008500 ATP-dependent helicase HepA; Validated; Region: PRK04914 665029008501 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 665029008502 ATP binding site [chemical binding]; other site 665029008503 putative Mg++ binding site [ion binding]; other site 665029008504 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 665029008505 nucleotide binding region [chemical binding]; other site 665029008506 ATP-binding site [chemical binding]; other site 665029008507 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 665029008508 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 665029008509 active site 665029008510 Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430 665029008511 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 665029008512 putative metal binding site [ion binding]; other site 665029008513 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 665029008514 HSP70 interaction site [polypeptide binding]; other site 665029008515 LPS assembly outer membrane complex protein LptD; Provisional; Region: PRK03761 665029008516 OstA-like protein; Region: OstA; pfam03968 665029008517 Organic solvent tolerance protein; Region: OstA_C; pfam04453 665029008518 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 665029008519 SurA N-terminal domain; Region: SurA_N; pfam09312 665029008520 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 665029008521 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 665029008522 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 665029008523 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 665029008524 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 665029008525 S-adenosylmethionine binding site [chemical binding]; other site 665029008526 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 665029008527 diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166 665029008528 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 665029008529 active site 665029008530 metal binding site [ion binding]; metal-binding site 665029008531 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 665029008532 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 665029008533 folate binding site [chemical binding]; other site 665029008534 NADP+ binding site [chemical binding]; other site 665029008535 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 665029008536 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 665029008537 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 665029008538 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 665029008539 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 665029008540 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 665029008541 ATP-grasp domain; Region: ATP-grasp_4; cl17255 665029008542 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 665029008543 IMP binding site; other site 665029008544 dimer interface [polypeptide binding]; other site 665029008545 interdomain contacts; other site 665029008546 partial ornithine binding site; other site 665029008547 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 665029008548 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 665029008549 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 665029008550 catalytic site [active] 665029008551 subunit interface [polypeptide binding]; other site 665029008552 dihydrodipicolinate reductase; Provisional; Region: PRK00048 665029008553 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 665029008554 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 665029008555 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 665029008556 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 665029008557 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 665029008558 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 665029008559 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 665029008560 lipoprotein signal peptidase; Provisional; Region: PRK14787 665029008561 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 665029008562 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 665029008563 active site 665029008564 HIGH motif; other site 665029008565 nucleotide binding site [chemical binding]; other site 665029008566 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 665029008567 active site 665029008568 KMSKS motif; other site 665029008569 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 665029008570 tRNA binding surface [nucleotide binding]; other site 665029008571 anticodon binding site; other site 665029008572 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 665029008573 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 665029008574 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 665029008575 active site 665029008576 Riboflavin kinase; Region: Flavokinase; smart00904 665029008577 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 665029008578 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09561 665029008579 chaperone protein DnaJ; Provisional; Region: PRK10767 665029008580 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 665029008581 HSP70 interaction site [polypeptide binding]; other site 665029008582 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 665029008583 substrate binding site [polypeptide binding]; other site 665029008584 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 665029008585 Zn binding sites [ion binding]; other site 665029008586 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 665029008587 dimer interface [polypeptide binding]; other site 665029008588 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 665029008589 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 665029008590 nucleotide binding site [chemical binding]; other site 665029008591 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 665029008592 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 665029008593 MPT binding site; other site 665029008594 trimer interface [polypeptide binding]; other site 665029008595 transaldolase-like protein; Provisional; Region: PTZ00411 665029008596 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 665029008597 active site 665029008598 dimer interface [polypeptide binding]; other site 665029008599 catalytic residue [active] 665029008600 hypothetical protein; Validated; Region: PRK02101 665029008601 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 665029008602 threonine synthase; Validated; Region: PRK09225 665029008603 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 665029008604 catalytic residue [active] 665029008605 homoserine kinase; Provisional; Region: PRK01212 665029008606 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 665029008607 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 665029008608 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 665029008609 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 665029008610 putative aspartate binding site [chemical binding]; other site 665029008611 putative catalytic residues [active] 665029008612 putative nucleotide binding site [chemical binding]; other site 665029008613 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 665029008614 dimer interface [polypeptide binding]; other site 665029008615 putative threonine allosteric regulatory site; other site 665029008616 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922 665029008617 putative threonine allosteric regulatory site; other site 665029008618 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 665029008619 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 665029008620 two-component response regulator; Provisional; Region: PRK11173 665029008621 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 665029008622 active site 665029008623 phosphorylation site [posttranslational modification] 665029008624 intermolecular recognition site; other site 665029008625 dimerization interface [polypeptide binding]; other site 665029008626 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 665029008627 DNA binding site [nucleotide binding] 665029008628 hypothetical protein; Provisional; Region: PRK10756 665029008629 CreA protein; Region: CreA; pfam05981 665029008630 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 665029008631 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 665029008632 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 665029008633 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 665029008634 catalytic core [active] 665029008635 inosine/xanthosine triphosphatase; Reviewed; Region: PRK05074 665029008636 Trp operon repressor; Provisional; Region: PRK01381 665029008637 lytic murein transglycosylase; Provisional; Region: PRK11619 665029008638 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 665029008639 N-acetyl-D-glucosamine binding site [chemical binding]; other site 665029008640 catalytic residue [active] 665029008641 DNA-binding transcriptional repressor DeoR; Provisional; Region: PRK10681 665029008642 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 665029008643 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 665029008644 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 665029008645 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 665029008646 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 665029008647 ABC transporter; Region: ABC_tran_2; pfam12848 665029008648 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 665029008649 Transcriptional regulator [Transcription]; Region: LysR; COG0583 665029008650 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 665029008651 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 665029008652 putative effector binding pocket; other site 665029008653 dimerization interface [polypeptide binding]; other site 665029008654 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 665029008655 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 665029008656 putative NAD(P) binding site [chemical binding]; other site 665029008657 dimer interface [polypeptide binding]; other site 665029008658 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 665029008659 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 665029008660 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 665029008661 non-specific DNA binding site [nucleotide binding]; other site 665029008662 salt bridge; other site 665029008663 bifunctional DNA-binding transcriptional repressor/ NMN adenylyltransferase; Provisional; Region: PRK08099 665029008664 sequence-specific DNA binding site [nucleotide binding]; other site 665029008665 Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional NadR-like proteins; Region: NMNAT_NadR; cd02167 665029008666 active site 665029008667 (T/H)XGH motif; other site 665029008668 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 665029008669 DNA repair protein RadA; Region: sms; TIGR00416 665029008670 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 665029008671 Walker A motif/ATP binding site; other site 665029008672 ATP binding site [chemical binding]; other site 665029008673 Walker B motif; other site 665029008674 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 665029008675 phosphoserine phosphatase; Provisional; Region: serB; PRK11133 665029008676 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 665029008677 motif II; other site 665029008678 hypothetical protein; Provisional; Region: PRK11246 665029008679 putative DNA-binding transcriptional regulator; Provisional; Region: PRK09775 665029008680 HipA-like C-terminal domain; Region: HipA_C; pfam07804 665029008681 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 665029008682 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 665029008683 phosphopentomutase; Provisional; Region: PRK05362 665029008684 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 665029008685 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 665029008686 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 665029008687 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 665029008688 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; cl06734 665029008689 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 665029008690 intersubunit interface [polypeptide binding]; other site 665029008691 active site 665029008692 catalytic residue [active] 665029008693 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 665029008694 active site 665029008695 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 665029008696 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 665029008697 active site 665029008698 nucleophile elbow; other site 665029008699 periplasmic protein; Provisional; Region: PRK10568 665029008700 BON domain; Region: BON; pfam04972 665029008701 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 665029008702 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 665029008703 G1 box; other site 665029008704 putative GEF interaction site [polypeptide binding]; other site 665029008705 GTP/Mg2+ binding site [chemical binding]; other site 665029008706 Switch I region; other site 665029008707 G2 box; other site 665029008708 G3 box; other site 665029008709 Switch II region; other site 665029008710 G4 box; other site 665029008711 G5 box; other site 665029008712 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 665029008713 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 665029008714 potential protein location (hypothetical protein predicted by Glimmer/Critica) that overlaps protein ( O-acetyltransferase SAV0974 )) 665029008715 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 665029008716 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 665029008717 C-terminal region of Pasteurella multocida toxin residues 569-1285; Region: PMT_C; pfam11647 665029008718 potential frameshift: common BLAST hit: gi|162419214|ref|YP_001604818.1| TonB-dependent siderophore receptor 665029008719 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 665029008720 potential frameshift: common BLAST hit: gi|186896703|ref|YP_001873815.1| TonB-dependent siderophore receptor 665029008721 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 665029008722 PAAR motif; Region: PAAR_motif; pfam05488 665029008723 RHS Repeat; Region: RHS_repeat; pfam05593 665029008724 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 665029008725 RHS Repeat; Region: RHS_repeat; pfam05593 665029008726 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 665029008727 RHS Repeat; Region: RHS_repeat; cl11982 665029008728 RHS Repeat; Region: RHS_repeat; pfam05593 665029008729 RHS Repeat; Region: RHS_repeat; cl11982 665029008730 RHS Repeat; Region: RHS_repeat; cl11982 665029008731 RHS protein; Region: RHS; pfam03527 665029008732 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 665029008733 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 665029008734 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 665029008735 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 665029008736 PAAR motif; Region: PAAR_motif; pfam05488 665029008737 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 665029008738 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 665029008739 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 665029008740 Protein kinase domain; Region: Pkinase; pfam00069 665029008741 Catalytic domain of Protein Kinases; Region: PKc; cd00180 665029008742 active site 665029008743 ATP binding site [chemical binding]; other site 665029008744 substrate binding site [chemical binding]; other site 665029008745 activation loop (A-loop); other site 665029008746 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 665029008747 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 665029008748 Walker A motif; other site 665029008749 ATP binding site [chemical binding]; other site 665029008750 Walker B motif; other site 665029008751 arginine finger; other site 665029008752 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 665029008753 Walker A motif; other site 665029008754 ATP binding site [chemical binding]; other site 665029008755 Walker B motif; other site 665029008756 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 665029008757 Protein of unknown function (DUF1305); Region: DUF1305; pfam06996 665029008758 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 665029008759 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 665029008760 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 665029008761 Protein of avirulence locus involved in temperature-dependent protein secretion [General function prediction only]; Region: ImpE; COG4455 665029008762 ImpE protein; Region: ImpE; pfam07024 665029008763 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 665029008764 active site 665029008765 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 665029008766 phosphopeptide binding site; other site 665029008767 type VI secretion system FHA domain protein; Region: VI_FHA; TIGR03354 665029008768 Protein of unknown function (DUF1311); Region: DUF1311; cl01530 665029008769 Domain of unknown function (DUF4285); Region: DUF4285; pfam14113 665029008770 Protein of unknown function (DUF796); Region: DUF796; pfam05638 665029008771 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517 665029008772 Protein of unknown function (DUF877); Region: DUF877; pfam05943 665029008773 Protein of unknown function (DUF770); Region: DUF770; pfam05591 665029008774 type VI secretion-associated protein, ImpA family; Region: VI_chp_8; TIGR03363 665029008775 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 665029008776 Uncharacterized protein conserved in bacteria (DUF2094); Region: DUF2094; pfam09867 665029008777 type VI secretion protein IcmF; Region: VI_IcmF; TIGR03348 665029008778 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 665029008779 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 665029008780 hypothetical protein; Provisional; Region: PRK07033 665029008781 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850 665029008782 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 665029008783 ligand binding site [chemical binding]; other site 665029008784 type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353 665029008785 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 665029008786 Type VI secretion lipoprotein; Region: T6SS-SciN; pfam12790 665029008787 dUMP phosphatase; Provisional; Region: PRK09449 665029008788 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 665029008789 motif II; other site 665029008790 ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491 665029008791 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 665029008792 DNA polymerase III subunit psi; Validated; Region: PRK06856 665029008793 16S ribosomal RNA m2G1207 methyltransferase; Provisional; Region: rsmC; PRK09489 665029008794 Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468 665029008795 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 665029008796 S-adenosylmethionine binding site [chemical binding]; other site 665029008797 Protein of unknown function (DUF1435); Region: DUF1435; pfam07256 665029008798 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 665029008799 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 665029008800 metal binding site [ion binding]; metal-binding site 665029008801 active site 665029008802 I-site; other site 665029008803 putative sialic acid transporter; Region: 2A0112; TIGR00891 665029008804 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 665029008805 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 665029008806 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cd00455 665029008807 active site 665029008808 Transcriptional regulators [Transcription]; Region: PurR; COG1609 665029008809 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 665029008810 DNA binding site [nucleotide binding] 665029008811 domain linker motif; other site 665029008812 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 665029008813 dimerization interface [polypeptide binding]; other site 665029008814 ligand binding site [chemical binding]; other site 665029008815 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 665029008816 metabolite-proton symporter; Region: 2A0106; TIGR00883 665029008817 putative substrate translocation pore; other site 665029008818 Protein of unknown function (DUF2931); Region: DUF2931; pfam11153 665029008819 Protein of unknown function (DUF2931); Region: DUF2931; pfam11153 665029008820 Protein of unknown function (DUF2931); Region: DUF2931; pfam11153 665029008821 Protein of unknown function (DUF2931); Region: DUF2931; pfam11153 665029008822 PAAR motif; Region: PAAR_motif; pfam05488 665029008823 Uncharacterized conserved protein (DUF2235); Region: DUF2235; cl01480 665029008824 Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606 665029008825 Catalytic domain of EDTA-resistant nuclease Nuc from Salmonella typhimurium and similar proteins; Region: PLDc_Nuc; cd09170 665029008826 PLD-like domain; Region: PLDc_2; pfam13091 665029008827 putative active site [active] 665029008828 catalytic site [active] 665029008829 Predicted transcriptional regulator [Transcription]; Region: COG2932 665029008830 Bacteriophage CI repressor helix-turn-helix domain; Region: Phage_CI_repr; pfam07022 665029008831 D-arabinose 5-phosphate isomerase; Provisional; Region: gutQ; PRK11543 665029008832 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 665029008833 putative active site [active] 665029008834 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 665029008835 DNA-bindng transcriptional repressor SrlR; Provisional; Region: srlR; PRK10434 665029008836 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 665029008837 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 665029008838 DNA-binding transcriptional activator GutM; Provisional; Region: PRK10234 665029008839 sorbitol-6-phosphate dehydrogenase; Provisional; Region: PRK12384 665029008840 Sorbitol 6-phosphate dehydrogenase (SDH), classical (c) SDRs; Region: SDH_SDR_c_like; cd05322 665029008841 putative NAD(P) binding site [chemical binding]; other site 665029008842 active site 665029008843 PTS system, glucitol/sorbitol-specific IIA component; Region: gutA; TIGR00849 665029008844 PTS system, glucitol/sorbitol-specific, IIBC component; Region: EIIBC-GUT; TIGR00825 665029008845 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 665029008846 Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663 665029008847 PTS system, glucitol/sorbitol-specific, IIC component; Region: EII-GUT; TIGR00821 665029008848 coenzyme PQQ biosynthesis probable peptidase PqqF; Region: PQQ_syn_pqqF; TIGR02110 665029008849 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 665029008850 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 665029008851 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 665029008852 pyrroloquinoline quinone biosynthesis protein PqqE; Provisional; Region: PRK05301 665029008853 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 665029008854 FeS/SAM binding site; other site 665029008855 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 665029008856 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 665029008857 pyrroloquinoline quinone biosynthesis protein PqqC; Provisional; Region: PRK05157 665029008858 pyrroloquinoline quinone biosynthesis protein PqqB; Provisional; Region: PRK05184 665029008859 coenzyme PQQ biosynthesis protein B; Region: PQQ_syn_pqqB; TIGR02108 665029008860 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 665029008861 active site 665029008862 dimer interface [polypeptide binding]; other site 665029008863 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 665029008864 high affinity sulphate transporter 1; Region: sulP; TIGR00815 665029008865 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 665029008866 Sulfate transporter family; Region: Sulfate_transp; pfam00916 665029008867 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 665029008868 active site clefts [active] 665029008869 zinc binding site [ion binding]; other site 665029008870 dimer interface [polypeptide binding]; other site 665029008871 potential protein location (hypothetical protein predicted by Glimmer/Critica) that overlaps protein (hypothetical protein predicted by Glimmer/Critica) 665029008872 potential protein location (hypothetical protein predicted by Glimmer/Critica) that overlaps protein (hypothetical protein predicted by Glimmer/Critica) 665029008873 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 665029008874 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 665029008875 active site 665029008876 FMN binding site [chemical binding]; other site 665029008877 2,4-decadienoyl-CoA binding site; other site 665029008878 catalytic residue [active] 665029008879 4Fe-4S cluster binding site [ion binding]; other site 665029008880 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 665029008881 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 665029008882 SAM-dependent 23S ribosomal RNA mG1835 methyltransferase; Provisional; Region: PRK15001 665029008883 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 665029008884 S-adenosylmethionine binding site [chemical binding]; other site 665029008885 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451 665029008886 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 665029008887 Major Facilitator Superfamily; Region: MFS_1; pfam07690 665029008888 putative substrate translocation pore; other site 665029008889 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 665029008890 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 665029008891 active site 665029008892 motif I; other site 665029008893 motif II; other site 665029008894 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 665029008895 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 665029008896 NAD(P) binding site [chemical binding]; other site 665029008897 putative voltage-gated ClC-type chloride channel ClcB; Provisional; Region: PRK01862 665029008898 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 665029008899 Cl- selectivity filter; other site 665029008900 Cl- binding residues [ion binding]; other site 665029008901 pore gating glutamate residue; other site 665029008902 dimer interface [polypeptide binding]; other site 665029008903 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 665029008904 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 665029008905 serine/threonine transporter SstT; Provisional; Region: PRK13628 665029008906 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 665029008907 small toxic polypeptide; Provisional; Region: PRK09738 665029008908 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 665029008909 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 665029008910 EnvZ/OmpR regulon moderator; Provisional; Region: PRK10629 665029008911 Protein of unknown function (DUF1090); Region: DUF1090; pfam06476 665029008912 Uncharacterized conserved protein [Function unknown]; Region: ElaB; COG4575 665029008913 Predicted membrane protein [Function unknown]; Region: COG5393 665029008914 YqjK-like protein; Region: YqjK; pfam13997 665029008915 Predicted membrane protein [Function unknown]; Region: COG2259 665029008916 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 665029008917 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 665029008918 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 665029008919 dimerization interface [polypeptide binding]; other site 665029008920 Pirin-related protein [General function prediction only]; Region: COG1741 665029008921 Pirin; Region: Pirin; pfam02678 665029008922 SAM-dependent 16S ribosomal RNA C1402 ribose 2'-O-methyltransferase; Provisional; Region: PRK14994 665029008923 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 665029008924 putative SAM binding site [chemical binding]; other site 665029008925 putative homodimer interface [polypeptide binding]; other site 665029008926 Putative lipoprotein [General function prediction only]; Region: LppC; COG3107 665029008927 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 665029008928 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 665029008929 putative ligand binding site [chemical binding]; other site 665029008930 hypothetical protein; Reviewed; Region: PRK12497 665029008931 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 665029008932 dimer interface [polypeptide binding]; other site 665029008933 active site 665029008934 outer membrane lipoprotein; Provisional; Region: PRK11023 665029008935 BON domain; Region: BON; pfam04972 665029008936 BON domain; Region: BON; pfam04972 665029008937 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 665029008938 HTH domain; Region: HTH_11; pfam08279 665029008939 Mga helix-turn-helix domain; Region: Mga; pfam05043 665029008940 PRD domain; Region: PRD; pfam00874 665029008941 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 665029008942 active site 665029008943 P-loop; other site 665029008944 phosphorylation site [posttranslational modification] 665029008945 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 665029008946 active site 665029008947 phosphorylation site [posttranslational modification] 665029008948 conserved hypothetical protein EF_0839/AHA_3917; Region: EF_0839; TIGR03581 665029008949 uncharacterized pyridoxal phosphate-dependent enzyme; Region: selA_rel; TIGR01437 665029008950 catalytic residue [active] 665029008951 dihydroorotase; Provisional; Region: PRK09237 665029008952 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 665029008953 active site 665029008954 conserved hypothetical protein EF_0833/AHA_3914; Region: EF_0833; TIGR03579 665029008955 conserved hypothetical protein EF_0832/AHA_3913; Region: EF_0832; TIGR03580 665029008956 Domain of unknown function (DUF4312); Region: DUF4312; pfam14189 665029008957 Glycine-rich SFCGS; Region: Gly_rich_SFCGS; pfam14272 665029008958 PRD domain protein EF_0829/AHA_3910; Region: EF_0829; TIGR03582 665029008959 peptidase PmbA; Provisional; Region: PRK11040 665029008960 hypothetical protein; Provisional; Region: PRK05255 665029008961 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 665029008962 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 665029008963 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 665029008964 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 665029008965 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 665029008966 AMP binding site [chemical binding]; other site 665029008967 metal binding site [ion binding]; metal-binding site 665029008968 active site 665029008969 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 665029008970 dimer interface [polypeptide binding]; other site 665029008971 ligand binding site [chemical binding]; other site 665029008972 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 665029008973 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 665029008974 dimerization interface [polypeptide binding]; other site 665029008975 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 665029008976 dimer interface [polypeptide binding]; other site 665029008977 putative CheW interface [polypeptide binding]; other site 665029008978 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 665029008979 dimer interface [polypeptide binding]; other site 665029008980 substrate binding site [chemical binding]; other site 665029008981 metal binding sites [ion binding]; metal-binding site 665029008982 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 665029008983 putative active site pocket [active] 665029008984 dimerization interface [polypeptide binding]; other site 665029008985 putative catalytic residue [active] 665029008986 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 665029008987 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 665029008988 Family of unknown function (DUF490); Region: DUF490; pfam04357 665029008989 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 665029008990 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 665029008991 Surface antigen; Region: Bac_surface_Ag; pfam01103 665029008992 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 665029008993 Domain of unknown function DUF21; Region: DUF21; pfam01595 665029008994 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 665029008995 Transporter associated domain; Region: CorC_HlyC; smart01091 665029008996 Protein of unknown function (DUF1107); Region: DUF1107; pfam06526 665029008997 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 665029008998 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 665029008999 active site 665029009000 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420 665029009001 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 665029009002 active site 665029009003 metal binding site [ion binding]; metal-binding site 665029009004 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 665029009005 peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK11570 665029009006 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 665029009007 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 665029009008 Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225 665029009009 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 665029009010 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 665029009011 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 665029009012 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 665029009013 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 665029009014 dimer interface [polypeptide binding]; other site 665029009015 ssDNA binding site [nucleotide binding]; other site 665029009016 tetramer (dimer of dimers) interface [polypeptide binding]; other site 665029009017 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 665029009018 esterase; Provisional; Region: PRK10566 665029009019 Bacterial sugar transferase; Region: Bac_transf; cl00939 665029009020 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 665029009021 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 665029009022 dimerization interface [polypeptide binding]; other site 665029009023 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 665029009024 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 665029009025 dimer interface [polypeptide binding]; other site 665029009026 putative CheW interface [polypeptide binding]; other site 665029009027 putative biofilm stress and motility protein A; Provisional; Region: PRK14864 665029009028 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 665029009029 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 665029009030 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 665029009031 exoribonuclease R; Provisional; Region: PRK11642 665029009032 Ribonuclease R winged-helix domain; Region: HTH_12; pfam08461 665029009033 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 665029009034 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 665029009035 RNB domain; Region: RNB; pfam00773 665029009036 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 665029009037 RNA binding site [nucleotide binding]; other site 665029009038 Transcriptional regulator; Region: Rrf2; cl17282 665029009039 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 665029009040 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 665029009041 GDP-binding site [chemical binding]; other site 665029009042 ACT binding site; other site 665029009043 IMP binding site; other site 665029009044 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3242 665029009045 FtsH protease regulator HflC; Provisional; Region: PRK11029 665029009046 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 665029009047 FtsH protease regulator HflK; Provisional; Region: PRK10930 665029009048 Bacterial membrane protein N terminal; Region: HflK_N; pfam12221 665029009049 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 665029009050 GTPase HflX; Provisional; Region: PRK11058 665029009051 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 665029009052 HflX GTPase family; Region: HflX; cd01878 665029009053 G1 box; other site 665029009054 GTP/Mg2+ binding site [chemical binding]; other site 665029009055 Switch I region; other site 665029009056 G2 box; other site 665029009057 G3 box; other site 665029009058 Switch II region; other site 665029009059 G4 box; other site 665029009060 G5 box; other site 665029009061 bacterial Hfq-like; Region: Hfq; cd01716 665029009062 hexamer interface [polypeptide binding]; other site 665029009063 Sm1 motif; other site 665029009064 RNA binding site [nucleotide binding]; other site 665029009065 Sm2 motif; other site 665029009066 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 665029009067 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 665029009068 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 665029009069 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 665029009070 ATP binding site [chemical binding]; other site 665029009071 Mg2+ binding site [ion binding]; other site 665029009072 G-X-G motif; other site 665029009073 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 665029009074 ATP binding site [chemical binding]; other site 665029009075 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 665029009076 N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431 665029009077 AMIN domain; Region: AMIN; pfam11741 665029009078 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 665029009079 active site 665029009080 metal binding site [ion binding]; metal-binding site 665029009081 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 665029009082 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 665029009083 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 665029009084 ADP-binding protein; Provisional; Region: PRK10646 665029009085 putative carbohydrate kinase; Provisional; Region: PRK10565 665029009086 Uncharacterized conserved protein [Function unknown]; Region: COG0062 665029009087 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 665029009088 putative substrate binding site [chemical binding]; other site 665029009089 putative ATP binding site [chemical binding]; other site 665029009090 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 665029009091 catalytic site [active] 665029009092 putative active site [active] 665029009093 putative substrate binding site [chemical binding]; other site 665029009094 dimer interface [polypeptide binding]; other site 665029009095 GTPase RsgA; Reviewed; Region: PRK12288 665029009096 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 665029009097 RNA binding site [nucleotide binding]; other site 665029009098 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 665029009099 GTPase/Zn-binding domain interface [polypeptide binding]; other site 665029009100 GTP/Mg2+ binding site [chemical binding]; other site 665029009101 G4 box; other site 665029009102 G5 box; other site 665029009103 G1 box; other site 665029009104 Switch I region; other site 665029009105 G2 box; other site 665029009106 G3 box; other site 665029009107 Switch II region; other site 665029009108 phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044 665029009109 putative mechanosensitive channel protein; Provisional; Region: PRK10929 665029009110 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 665029009111 Mechanosensitive ion channel; Region: MS_channel; pfam00924 665029009112 poxB regulator PoxA; Provisional; Region: PRK09350 665029009113 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 665029009114 motif 1; other site 665029009115 dimer interface [polypeptide binding]; other site 665029009116 active site 665029009117 motif 2; other site 665029009118 motif 3; other site 665029009119 outer membrane lipoprotein Blc; Provisional; Region: PRK10477 665029009120 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 665029009121 Predicted small secreted protein [Function unknown]; Region: COG5510 665029009122 Papain-like cysteine protease AvrRpt2; Region: Peptidase_C70; pfam12385 665029009123 elongation factor P; Validated; Region: PRK00529 665029009124 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 665029009125 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 665029009126 RNA binding site [nucleotide binding]; other site 665029009127 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 665029009128 RNA binding site [nucleotide binding]; other site 665029009129 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 665029009130 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 665029009131 FeS/SAM binding site; other site 665029009132 Domain of unknown function (DUF4156); Region: DUF4156; pfam13698 665029009133 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 665029009134 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 665029009135 ring oligomerisation interface [polypeptide binding]; other site 665029009136 ATP/Mg binding site [chemical binding]; other site 665029009137 stacking interactions; other site 665029009138 hinge regions; other site 665029009139 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 665029009140 oligomerisation interface [polypeptide binding]; other site 665029009141 mobile loop; other site 665029009142 roof hairpin; other site 665029009143 Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030 665029009144 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 665029009145 Aspartase; Region: Aspartase; cd01357 665029009146 active sites [active] 665029009147 tetramer interface [polypeptide binding]; other site 665029009148 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 665029009149 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 665029009150 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 665029009151 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 665029009152 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 665029009153 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 665029009154 DsbD alpha interface [polypeptide binding]; other site 665029009155 catalytic residues [active] 665029009156 putative transcriptional regulator; Provisional; Region: PRK11640 665029009157 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 665029009158 Major Facilitator Superfamily; Region: MFS_1; pfam07690 665029009159 Major Facilitator Superfamily; Region: MFS_1; pfam07690 665029009160 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 665029009161 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 665029009162 active site 665029009163 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 665029009164 dimer interface [polypeptide binding]; other site 665029009165 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 665029009166 Ligand Binding Site [chemical binding]; other site 665029009167 Molecular Tunnel; other site 665029009168 pantoate--beta-alanine ligase; Reviewed; Region: panC; PRK00380 665029009169 active site 665029009170 nucleotide binding site [chemical binding]; other site 665029009171 HIGH motif; other site 665029009172 KMSKS motif; other site 665029009173 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 665029009174 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 665029009175 ATP-grasp domain; Region: ATP-grasp_4; cl17255 665029009176 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 665029009177 histidyl-tRNA synthetase; Region: hisS; TIGR00442 665029009178 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 665029009179 dimer interface [polypeptide binding]; other site 665029009180 motif 1; other site 665029009181 active site 665029009182 motif 2; other site 665029009183 motif 3; other site 665029009184 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 665029009185 anticodon binding site; other site 665029009186 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 665029009187 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 665029009188 histidyl-tRNA synthetase; Region: hisS; TIGR00442 665029009189 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 665029009190 motif 1; other site 665029009191 dimer interface [polypeptide binding]; other site 665029009192 active site 665029009193 motif 2; other site 665029009194 Methyltransferase domain; Region: Methyltransf_31; pfam13847 665029009195 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 665029009196 S-adenosylmethionine binding site [chemical binding]; other site 665029009197 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 665029009198 conjugative transfer ATPase, PFL_4706 family; Region: traC_PFL_4706; TIGR03744 665029009199 potential frameshift: common BLAST hit: gi|157372320|ref|YP_001480309.1| plasmid-related protein 665029009200 F pilus assembly Type-IV secretion system for plasmid transfer; Region: TraC_F_IV; pfam11130 665029009201 F pilus assembly Type-IV secretion system for plasmid transfer; Region: TraC_F_IV; pfam11130 665029009202 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3515 665029009203 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 665029009204 ImpA domain protein; Region: DUF3702; pfam12486 665029009205 type VI secretion system lysozyme-like protein; Region: VI_zyme; TIGR03357 665029009206 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 665029009207 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733 665029009208 Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501 665029009209 Type VI secretion lipoprotein; Region: T6SS-SciN; pfam12790 665029009210 Domain of unknown function (DUF4123); Region: DUF4123; pfam13503 665029009211 Rhs element Vgr protein; Region: vgr_GE; TIGR01646 665029009212 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 665029009213 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 665029009214 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 665029009215 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106 665029009216 Type VI secretion lipoprotein; Region: T6SS-SciN; pfam12790 665029009217 Protein of unknown function (DUF1305); Region: DUF1305; pfam06996 665029009218 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 665029009219 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 665029009220 type VI secretion-associated protein, VC_A0119 family; Region: VI_chp_7; TIGR03362 665029009221 Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and vesicular transport]; Region: IcmF; COG3523 665029009222 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 665029009223 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 665029009224 PAAR motif; Region: PAAR_motif; pfam05488 665029009225 Rhs element Vgr protein; Region: vgr_GE; TIGR01646 665029009226 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 665029009227 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 665029009228 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 665029009229 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106 665029009230 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 665029009231 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 665029009232 Walker A motif; other site 665029009233 ATP binding site [chemical binding]; other site 665029009234 Walker B motif; other site 665029009235 arginine finger; other site 665029009236 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 665029009237 Walker A motif; other site 665029009238 ATP binding site [chemical binding]; other site 665029009239 Walker B motif; other site 665029009240 arginine finger; other site 665029009241 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 665029009242 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 665029009243 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 665029009244 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 665029009245 ligand binding site [chemical binding]; other site 665029009246 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850 665029009247 type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353 665029009248 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 665029009249 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517; cl05484 665029009250 Protein of unknown function (DUF877); Region: DUF877; pfam05943 665029009251 Protein of unknown function (DUF770); Region: DUF770; pfam05591 665029009252 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 665029009253 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 665029009254 Clostridium P-47 protein; Region: Clostridium_P47; pfam06597 665029009255 Clostridium P-47 protein; Region: Clostridium_P47; pfam06597 665029009256 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 665029009257 pyridoxal 5'-phosphate binding site [chemical binding]; other site 665029009258 catalytic residue [active] 665029009259 Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486 665029009260 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 665029009261 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 665029009262 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 665029009263 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 665029009264 IucA / IucC family; Region: IucA_IucC; pfam04183 665029009265 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 665029009266 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 665029009267 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 665029009268 N-terminal plug; other site 665029009269 ligand-binding site [chemical binding]; other site 665029009270 Domain of unknown function (DUF4354); Region: DUF4354; pfam14263 665029009271 glucose-1-dehydrogenase; Provisional; Region: PRK08936 665029009272 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 665029009273 NAD(P) binding site [chemical binding]; other site 665029009274 active site 665029009275 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 665029009276 dimerization interface [polypeptide binding]; other site 665029009277 putative DNA binding site [nucleotide binding]; other site 665029009278 putative Zn2+ binding site [ion binding]; other site 665029009279 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 665029009280 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 665029009281 FMN binding site [chemical binding]; other site 665029009282 active site 665029009283 substrate binding site [chemical binding]; other site 665029009284 catalytic residue [active] 665029009285 chaperone protein HchA; Provisional; Region: PRK04155 665029009286 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 665029009287 conserved cys residue [active] 665029009288 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 665029009289 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 665029009290 active site 665029009291 motif I; other site 665029009292 motif II; other site 665029009293 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 665029009294 Domain of unknown function (DUF1338); Region: DUF1338; pfam07063 665029009295 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 665029009296 N-terminal Early set domain associated with the catalytic domain of putative esterases; Region: E_set_Esterase_like_N; cd11294 665029009297 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 665029009298 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 665029009299 trehalase; Provisional; Region: treF; PRK13270 665029009300 Trehalase; Region: Trehalase; cl17346 665029009301 LysE type translocator; Region: LysE; cl00565 665029009302 Transcriptional regulator [Transcription]; Region: LysR; COG0583 665029009303 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 665029009304 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 665029009305 putative effector binding pocket; other site 665029009306 dimerization interface [polypeptide binding]; other site 665029009307 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 665029009308 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 665029009309 progesterone 5-beta-reductase-like proteins (5beta-POR), atypical (a) SDRs; Region: 5beta-POR_like_SDR_a; cd08948 665029009310 NAD(P) binding site [chemical binding]; other site 665029009311 active site 665029009312 Transcriptional regulator [Transcription]; Region: LysR; COG0583 665029009313 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 665029009314 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_6; cd08475 665029009315 putative effector binding pocket; other site 665029009316 putative dimerization interface [polypeptide binding]; other site 665029009317 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 665029009318 Acyltransferase family; Region: Acyl_transf_3; pfam01757 665029009319 PTS system arbutin-specific transporter subunit IIB; Provisional; Region: PRK09702 665029009320 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 665029009321 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 665029009322 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 665029009323 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 665029009324 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 665029009325 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 665029009326 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 665029009327 putative active site [active] 665029009328 cyclic-di-GMP phosphodiesterase; Provisional; Region: PRK11359 665029009329 heme pocket [chemical binding]; other site 665029009330 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 665029009331 putative active site [active] 665029009332 heme pocket [chemical binding]; other site 665029009333 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 665029009334 putative active site [active] 665029009335 heme pocket [chemical binding]; other site 665029009336 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 665029009337 metal binding site [ion binding]; metal-binding site 665029009338 active site 665029009339 I-site; other site 665029009340 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 665029009341 microcin B17 transporter; Reviewed; Region: PRK11098 665029009342 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cl00723 665029009343 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 665029009344 PAS domain; Region: PAS_9; pfam13426 665029009345 putative active site [active] 665029009346 heme pocket [chemical binding]; other site 665029009347 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 665029009348 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 665029009349 dimer interface [polypeptide binding]; other site 665029009350 putative CheW interface [polypeptide binding]; other site 665029009351 glutamate/aspartate:proton symporter; Provisional; Region: gltP; PRK11283 665029009352 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 665029009353 acetyl-CoA synthetase; Provisional; Region: PRK00174 665029009354 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 665029009355 active site 665029009356 CoA binding site [chemical binding]; other site 665029009357 acyl-activating enzyme (AAE) consensus motif; other site 665029009358 AMP binding site [chemical binding]; other site 665029009359 acetate binding site [chemical binding]; other site 665029009360 Predicted membrane protein [Function unknown]; Region: COG3162 665029009361 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 665029009362 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 665029009363 Na binding site [ion binding]; other site 665029009364 YfaZ precursor; Region: YfaZ; pfam07437 665029009365 outer membrane protein; Region: OMP_w_GlyGly; TIGR04219 665029009366 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 665029009367 Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380 665029009368 Transcriptional regulator [Transcription]; Region: LysR; COG0583 665029009369 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 665029009370 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 665029009371 putative dimerization interface [polypeptide binding]; other site 665029009372 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 665029009373 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 665029009374 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 665029009375 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 665029009376 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 665029009377 putative C-terminal domain interface [polypeptide binding]; other site 665029009378 putative GSH binding site (G-site) [chemical binding]; other site 665029009379 putative dimer interface [polypeptide binding]; other site 665029009380 C-terminal, alpha helical domain of GTT1-like Glutathione S-transferases; Region: GST_C_GTT1_like; cd03189 665029009381 putative N-terminal domain interface [polypeptide binding]; other site 665029009382 putative dimer interface [polypeptide binding]; other site 665029009383 putative substrate binding pocket (H-site) [chemical binding]; other site 665029009384 redox-sensitivie transcriptional activator SoxR; Provisional; Region: PRK15002 665029009385 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 665029009386 DNA binding residues [nucleotide binding] 665029009387 dimer interface [polypeptide binding]; other site 665029009388 [2Fe-2S] cluster binding site [ion binding]; other site 665029009389 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 665029009390 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 665029009391 Transposase; Region: HTH_Tnp_1; pfam01527 665029009392 Protein of unknown function (DUF3828); Region: DUF3828; pfam12883 665029009393 D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330 665029009394 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 665029009395 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 665029009396 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 665029009397 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 665029009398 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 665029009399 dimer interface [polypeptide binding]; other site 665029009400 ssDNA binding site [nucleotide binding]; other site 665029009401 tetramer (dimer of dimers) interface [polypeptide binding]; other site 665029009402 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 665029009403 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 665029009404 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 665029009405 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 665029009406 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 665029009407 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 665029009408 putative NAD(P) binding site [chemical binding]; other site 665029009409 putative substrate binding site [chemical binding]; other site 665029009410 catalytic Zn binding site [ion binding]; other site 665029009411 structural Zn binding site [ion binding]; other site 665029009412 dimer interface [polypeptide binding]; other site 665029009413 LysM domain; Region: LysM; pfam01476 665029009414 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 665029009415 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 665029009416 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 665029009417 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 665029009418 Uncharacterized conserved protein [Function unknown]; Region: COG0432 665029009419 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 665029009420 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 665029009421 pyridoxal 5'-phosphate binding site [chemical binding]; other site 665029009422 homodimer interface [polypeptide binding]; other site 665029009423 catalytic residue [active] 665029009424 Uncharacterized conserved protein [Function unknown]; Region: COG1284 665029009425 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 665029009426 replicative DNA helicase; Provisional; Region: PRK08006 665029009427 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 665029009428 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 665029009429 Walker A motif; other site 665029009430 ATP binding site [chemical binding]; other site 665029009431 Walker B motif; other site 665029009432 DNA binding loops [nucleotide binding] 665029009433 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 665029009434 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 665029009435 NADP binding site [chemical binding]; other site 665029009436 dimer interface [polypeptide binding]; other site 665029009437 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 665029009438 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 665029009439 FMN binding site [chemical binding]; other site 665029009440 active site 665029009441 catalytic residues [active] 665029009442 substrate binding site [chemical binding]; other site 665029009443 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 665029009444 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 665029009445 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 665029009446 Ligand binding site; other site 665029009447 Putative Catalytic site; other site 665029009448 DXD motif; other site 665029009449 Glucosyl transferase GtrII; Region: Glucos_trans_II; pfam14264 665029009450 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 665029009451 Phage holin family (Lysis protein S); Region: Phage_holin_3; cl04938 665029009452 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 665029009453 DNA methylase; Region: N6_N4_Mtase; pfam01555 665029009454 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 665029009455 Phage antitermination protein Q; Region: Phage_antitermQ; pfam06530 665029009456 Protein of unknown function (DUF968); Region: DUF968; pfam06147 665029009457 F plasmid transfer operon, TraF, protein; Region: TraF_2; pfam13729 665029009458 ferric uptake regulator; Provisional; Region: fur; PRK09462 665029009459 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 665029009460 metal binding site 2 [ion binding]; metal-binding site 665029009461 putative DNA binding helix; other site 665029009462 metal binding site 1 [ion binding]; metal-binding site 665029009463 dimer interface [polypeptide binding]; other site 665029009464 structural Zn2+ binding site [ion binding]; other site 665029009465 hypothetical protein; Provisional; Region: PRK10428 665029009466 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 665029009467 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 665029009468 LexA repressor; Validated; Region: PRK00215 665029009469 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 665029009470 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 665029009471 Catalytic site [active] 665029009472 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 665029009473 glycerol-3-phosphate O-acyltransferase; Region: plsB; TIGR03703 665029009474 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 665029009475 putative acyl-acceptor binding pocket; other site 665029009476 4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848 665029009477 UbiA prenyltransferase family; Region: UbiA; pfam01040 665029009478 chorismate pyruvate lyase; Provisional; Region: ubiC; PRK11655 665029009479 phosphate-starvation-inducible protein PsiE; Provisional; Region: PRK02833 665029009480 Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082 665029009481 Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251 665029009482 Protein of unknown function (DUF2886); Region: DUF2886; pfam11102 665029009483 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 665029009484 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 665029009485 active site 665029009486 dimer interface [polypeptide binding]; other site 665029009487 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 665029009488 dimer interface [polypeptide binding]; other site 665029009489 active site 665029009490 aspartate kinase III; Validated; Region: PRK09084 665029009491 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 665029009492 nucleotide binding site [chemical binding]; other site 665029009493 substrate binding site [chemical binding]; other site 665029009494 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 665029009495 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_2; cd04917 665029009496 dimer interface [polypeptide binding]; other site 665029009497 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 665029009498 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 665029009499 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 665029009500 PhoU domain; Region: PhoU; pfam01895 665029009501 homoserine O-succinyltransferase; Provisional; Region: PRK05368 665029009502 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 665029009503 proposed active site lysine [active] 665029009504 conserved cys residue [active] 665029009505 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 665029009506 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 665029009507 trimer interface [polypeptide binding]; other site 665029009508 putative metal binding site [ion binding]; other site 665029009509 Protein of unknown function (DUF1488); Region: DUF1488; pfam07369 665029009510 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 665029009511 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 665029009512 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 665029009513 shikimate binding site; other site 665029009514 NAD(P) binding site [chemical binding]; other site 665029009515 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 665029009516 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 665029009517 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 665029009518 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 665029009519 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 665029009520 hypothetical protein; Validated; Region: PRK03430 665029009521 hypothetical protein; Provisional; Region: PRK10736 665029009522 DNA protecting protein DprA; Region: dprA; TIGR00732 665029009523 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 665029009524 active site 665029009525 catalytic residues [active] 665029009526 metal binding site [ion binding]; metal-binding site 665029009527 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 665029009528 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 665029009529 putative active site [active] 665029009530 substrate binding site [chemical binding]; other site 665029009531 putative cosubstrate binding site; other site 665029009532 catalytic site [active] 665029009533 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 665029009534 substrate binding site [chemical binding]; other site 665029009535 16S rRNA methyltransferase B; Provisional; Region: PRK10901 665029009536 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 665029009537 putative RNA binding site [nucleotide binding]; other site 665029009538 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 665029009539 S-adenosylmethionine binding site [chemical binding]; other site 665029009540 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 665029009541 TrkA-N domain; Region: TrkA_N; pfam02254 665029009542 TrkA-C domain; Region: TrkA_C; pfam02080 665029009543 TrkA-N domain; Region: TrkA_N; pfam02254 665029009544 TrkA-C domain; Region: TrkA_C; pfam02080 665029009545 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 665029009546 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 665029009547 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3036 665029009548 zinc-responsive transcriptional regulator; Provisional; Region: zntR; PRK09514 665029009549 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 665029009550 DNA binding residues [nucleotide binding] 665029009551 dimer interface [polypeptide binding]; other site 665029009552 metal binding site [ion binding]; metal-binding site 665029009553 hypothetical protein; Provisional; Region: PRK10203 665029009554 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 665029009555 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 665029009556 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 665029009557 alphaNTD homodimer interface [polypeptide binding]; other site 665029009558 alphaNTD - beta interaction site [polypeptide binding]; other site 665029009559 alphaNTD - beta' interaction site [polypeptide binding]; other site 665029009560 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 665029009561 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 665029009562 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 665029009563 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 665029009564 RNA binding surface [nucleotide binding]; other site 665029009565 30S ribosomal protein S11; Validated; Region: PRK05309 665029009566 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 665029009567 30S ribosomal protein S13; Region: bact_S13; TIGR03631 665029009568 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 665029009569 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 665029009570 SecY translocase; Region: SecY; pfam00344 665029009571 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 665029009572 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 665029009573 23S rRNA binding site [nucleotide binding]; other site 665029009574 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 665029009575 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 665029009576 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 665029009577 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 665029009578 23S rRNA interface [nucleotide binding]; other site 665029009579 5S rRNA interface [nucleotide binding]; other site 665029009580 L27 interface [polypeptide binding]; other site 665029009581 L5 interface [polypeptide binding]; other site 665029009582 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 665029009583 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 665029009584 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 665029009585 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 665029009586 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 665029009587 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 665029009588 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 665029009589 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 665029009590 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 665029009591 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 665029009592 RNA binding site [nucleotide binding]; other site 665029009593 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 665029009594 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 665029009595 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 665029009596 23S rRNA interface [nucleotide binding]; other site 665029009597 putative translocon interaction site; other site 665029009598 signal recognition particle (SRP54) interaction site; other site 665029009599 L23 interface [polypeptide binding]; other site 665029009600 trigger factor interaction site; other site 665029009601 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 665029009602 23S rRNA interface [nucleotide binding]; other site 665029009603 5S rRNA interface [nucleotide binding]; other site 665029009604 putative antibiotic binding site [chemical binding]; other site 665029009605 L25 interface [polypeptide binding]; other site 665029009606 L27 interface [polypeptide binding]; other site 665029009607 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 665029009608 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 665029009609 G-X-X-G motif; other site 665029009610 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 665029009611 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 665029009612 protein-rRNA interface [nucleotide binding]; other site 665029009613 putative translocon binding site; other site 665029009614 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 665029009615 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 665029009616 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 665029009617 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 665029009618 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 665029009619 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 665029009620 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 665029009621 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 665029009622 elongation factor Tu; Reviewed; Region: PRK00049 665029009623 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 665029009624 G1 box; other site 665029009625 GEF interaction site [polypeptide binding]; other site 665029009626 GTP/Mg2+ binding site [chemical binding]; other site 665029009627 Switch I region; other site 665029009628 G2 box; other site 665029009629 G3 box; other site 665029009630 Switch II region; other site 665029009631 G4 box; other site 665029009632 G5 box; other site 665029009633 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 665029009634 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 665029009635 Antibiotic Binding Site [chemical binding]; other site 665029009636 elongation factor G; Reviewed; Region: PRK00007 665029009637 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 665029009638 G1 box; other site 665029009639 putative GEF interaction site [polypeptide binding]; other site 665029009640 GTP/Mg2+ binding site [chemical binding]; other site 665029009641 Switch I region; other site 665029009642 G2 box; other site 665029009643 G3 box; other site 665029009644 Switch II region; other site 665029009645 G4 box; other site 665029009646 G5 box; other site 665029009647 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 665029009648 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 665029009649 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 665029009650 30S ribosomal protein S7; Validated; Region: PRK05302 665029009651 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 665029009652 S17 interaction site [polypeptide binding]; other site 665029009653 S8 interaction site; other site 665029009654 16S rRNA interaction site [nucleotide binding]; other site 665029009655 streptomycin interaction site [chemical binding]; other site 665029009656 23S rRNA interaction site [nucleotide binding]; other site 665029009657 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 665029009658 sulfur transfer complex subunit TusB; Provisional; Region: PRK13510 665029009659 sulfur relay protein TusC; Validated; Region: PRK00211 665029009660 sulfur transfer complex subunit TusD; Validated; Region: PRK00207 665029009661 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 665029009662 YheO-like PAS domain; Region: PAS_6; pfam08348 665029009663 HTH domain; Region: HTH_22; pfam13309 665029009664 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK10902 665029009665 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 665029009666 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 665029009667 phi X174 lysis protein; Provisional; Region: PRK02793 665029009668 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 665029009669 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 665029009670 Predicted nucleic-acid-binding protein containing a Zn-ribbon domain [General function prediction only]; Region: COG3529 665029009671 glutathione-regulated potassium-efflux system protein KefB; Provisional; Region: PRK03659 665029009672 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 665029009673 TrkA-N domain; Region: TrkA_N; pfam02254 665029009674 glutathione-regulated potassium-efflux system ancillary protein KefG; Provisional; Region: PRK04930 665029009675 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 665029009676 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 665029009677 Walker A/P-loop; other site 665029009678 ATP binding site [chemical binding]; other site 665029009679 Q-loop/lid; other site 665029009680 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 665029009681 ABC transporter; Region: ABC_tran_2; pfam12848 665029009682 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 665029009683 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 665029009684 taurine dioxygenase; Reviewed; Region: tauD; PRK09553 665029009685 active site 665029009686 iron coordination sites [ion binding]; other site 665029009687 substrate binding pocket [chemical binding]; other site 665029009688 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 665029009689 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 665029009690 dimer interface [polypeptide binding]; other site 665029009691 conserved gate region; other site 665029009692 putative PBP binding loops; other site 665029009693 ABC-ATPase subunit interface; other site 665029009694 taurine transporter ATP-binding subunit; Provisional; Region: tauB; PRK11248 665029009695 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 665029009696 Walker A/P-loop; other site 665029009697 ATP binding site [chemical binding]; other site 665029009698 Q-loop/lid; other site 665029009699 ABC transporter signature motif; other site 665029009700 Walker B; other site 665029009701 D-loop; other site 665029009702 H-loop/switch region; other site 665029009703 ABC-type taurine transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: TauA; COG4521 665029009704 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 665029009705 substrate binding pocket [chemical binding]; other site 665029009706 membrane-bound complex binding site; other site 665029009707 hinge residues; other site 665029009708 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 665029009709 putative hydrolase; Provisional; Region: PRK10985 665029009710 hypothetical protein; Provisional; Region: PRK04966 665029009711 phosphoribulokinase; Provisional; Region: PRK15453 665029009712 active site 665029009713 hypothetical protein; Provisional; Region: PRK10738 665029009714 DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753 665029009715 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 665029009716 ligand binding site [chemical binding]; other site 665029009717 flexible hinge region; other site 665029009718 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 665029009719 putative switch regulator; other site 665029009720 non-specific DNA interactions [nucleotide binding]; other site 665029009721 DNA binding site [nucleotide binding] 665029009722 sequence specific DNA binding site [nucleotide binding]; other site 665029009723 putative cAMP binding site [chemical binding]; other site 665029009724 integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667 665029009725 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 665029009726 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 665029009727 bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093 665029009728 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 665029009729 inhibitor-cofactor binding pocket; inhibition site 665029009730 pyridoxal 5'-phosphate binding site [chemical binding]; other site 665029009731 catalytic residue [active] 665029009732 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 665029009733 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 665029009734 glutamine binding [chemical binding]; other site 665029009735 catalytic triad [active] 665029009736 peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903 665029009737 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 665029009738 substrate binding site [chemical binding]; other site 665029009739 putative transporter; Provisional; Region: PRK03699 665029009740 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 665029009741 putative substrate translocation pore; other site 665029009742 cytosine deaminase; Provisional; Region: PRK09230 665029009743 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 665029009744 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 665029009745 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 665029009746 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 665029009747 active site 665029009748 HIGH motif; other site 665029009749 dimer interface [polypeptide binding]; other site 665029009750 KMSKS motif; other site 665029009751 phosphoglycolate phosphatase; Provisional; Region: PRK13222 665029009752 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 665029009753 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 665029009754 motif II; other site 665029009755 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 665029009756 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 665029009757 substrate binding site [chemical binding]; other site 665029009758 hexamer interface [polypeptide binding]; other site 665029009759 metal binding site [ion binding]; metal-binding site 665029009760 DNA adenine methylase; Provisional; Region: PRK10904 665029009761 hypothetical protein; Reviewed; Region: PRK11901 665029009762 cell division protein DamX; Validated; Region: PRK10905 665029009763 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 665029009764 active site 665029009765 dimer interface [polypeptide binding]; other site 665029009766 metal binding site [ion binding]; metal-binding site 665029009767 shikimate kinase; Reviewed; Region: aroK; PRK00131 665029009768 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 665029009769 ADP binding site [chemical binding]; other site 665029009770 magnesium binding site [ion binding]; other site 665029009771 putative shikimate binding site; other site 665029009772 putative outer membrane porin HofQ; Provisional; Region: hofQ; PRK13568 665029009773 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 665029009774 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 665029009775 Protein of unknown function (DUF2531); Region: DUF2531; pfam10748 665029009776 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 665029009777 Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972 665029009778 penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636 665029009779 Transglycosylase; Region: Transgly; pfam00912 665029009780 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 665029009781 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 665029009782 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 665029009783 ADP-ribose binding site [chemical binding]; other site 665029009784 dimer interface [polypeptide binding]; other site 665029009785 active site 665029009786 nudix motif; other site 665029009787 metal binding site [ion binding]; metal-binding site 665029009788 Intracellular growth attenuator protein IgaA; Region: IgaA; pfam07095 665029009789 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 665029009790 RNA binding surface [nucleotide binding]; other site 665029009791 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 665029009792 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 665029009793 dimerization interface [polypeptide binding]; other site 665029009794 domain crossover interface; other site 665029009795 redox-dependent activation switch; other site 665029009796 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 665029009797 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 665029009798 active site 665029009799 substrate-binding site [chemical binding]; other site 665029009800 metal-binding site [ion binding] 665029009801 ATP binding site [chemical binding]; other site 665029009802 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 665029009803 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 665029009804 dimerization interface [polypeptide binding]; other site 665029009805 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 665029009806 dimer interface [polypeptide binding]; other site 665029009807 phosphorylation site [posttranslational modification] 665029009808 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 665029009809 ATP binding site [chemical binding]; other site 665029009810 Mg2+ binding site [ion binding]; other site 665029009811 G-X-G motif; other site 665029009812 osmolarity response regulator; Provisional; Region: ompR; PRK09468 665029009813 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 665029009814 active site 665029009815 phosphorylation site [posttranslational modification] 665029009816 intermolecular recognition site; other site 665029009817 dimerization interface [polypeptide binding]; other site 665029009818 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 665029009819 DNA binding site [nucleotide binding] 665029009820 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 665029009821 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 665029009822 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 665029009823 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 665029009824 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 665029009825 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 665029009826 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 665029009827 RNA binding site [nucleotide binding]; other site 665029009828 Alpha amylase catalytic domain found in sucrose phosphorylase-like proteins (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase-like_1; cd11356 665029009829 sucrose phosphorylase; Provisional; Region: PRK13840 665029009830 active site 665029009831 homodimer interface [polypeptide binding]; other site 665029009832 catalytic site [active] 665029009833 carboxylesterase BioH; Provisional; Region: PRK10349 665029009834 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 665029009835 DNA utilization protein GntX; Provisional; Region: PRK11595 665029009836 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 665029009837 active site 665029009838 Fe/S biogenesis protein NfuA; Provisional; Region: PRK11190 665029009839 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 665029009840 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 665029009841 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 665029009842 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 665029009843 maltodextrin phosphorylase; Provisional; Region: PRK14985 665029009844 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 665029009845 active site pocket [active] 665029009846 DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906 665029009847 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 665029009848 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 665029009849 intramembrane serine protease GlpG; Provisional; Region: PRK10907 665029009850 Protein of unknown function (DUF3582); Region: DUF3582; pfam12122 665029009851 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 665029009852 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 665029009853 active site residue [active] 665029009854 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 665029009855 potential protein location (hypothetical protein predicted by Glimmer/Critica) that overlaps protein (hypothetical protein predicted by Glimmer/Critica) 665029009856 potential protein location (hypothetical protein predicted by Glimmer/Critica) that overlaps protein (hypothetical protein predicted by Glimmer/Critica) 665029009857 glycogen phosphorylase; Provisional; Region: PRK14986 665029009858 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 665029009859 homodimer interface [polypeptide binding]; other site 665029009860 active site pocket [active] 665029009861 glycogen synthase; Provisional; Region: glgA; PRK00654 665029009862 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 665029009863 ADP-binding pocket [chemical binding]; other site 665029009864 homodimer interface [polypeptide binding]; other site 665029009865 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 665029009866 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 665029009867 ligand binding site; other site 665029009868 oligomer interface; other site 665029009869 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 665029009870 dimer interface [polypeptide binding]; other site 665029009871 N-terminal domain interface [polypeptide binding]; other site 665029009872 sulfate 1 binding site; other site 665029009873 glycogen debranching enzyme; Provisional; Region: PRK03705 665029009874 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 665029009875 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 665029009876 active site 665029009877 catalytic site [active] 665029009878 glycogen branching enzyme; Provisional; Region: PRK05402 665029009879 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 665029009880 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 665029009881 active site 665029009882 catalytic site [active] 665029009883 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 665029009884 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 665029009885 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 665029009886 low affinity gluconate transporter; Provisional; Region: PRK10472 665029009887 gluconate transporter; Region: gntP; TIGR00791 665029009888 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 665029009889 ATP-binding site [chemical binding]; other site 665029009890 Gluconate-6-phosphate binding site [chemical binding]; other site 665029009891 Shikimate kinase; Region: SKI; pfam01202 665029009892 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 665029009893 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 665029009894 DNA binding site [nucleotide binding] 665029009895 domain linker motif; other site 665029009896 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 665029009897 putative ligand binding site [chemical binding]; other site 665029009898 putative dimerization interface [polypeptide binding]; other site 665029009899 Pirin-related protein [General function prediction only]; Region: COG1741 665029009900 Pirin; Region: Pirin; pfam02678 665029009901 putative acetyltransferase YhhY; Provisional; Region: PRK10140 665029009902 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 665029009903 Coenzyme A binding pocket [chemical binding]; other site 665029009904 gamma-glutamyltranspeptidase; Reviewed; Region: ggt; PRK09615 665029009905 gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066 665029009906 cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454 665029009907 Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562 665029009908 putative active site [active] 665029009909 catalytic site [active] 665029009910 putative metal binding site [ion binding]; other site 665029009911 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 665029009912 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 665029009913 Walker A/P-loop; other site 665029009914 ATP binding site [chemical binding]; other site 665029009915 Q-loop/lid; other site 665029009916 ABC transporter signature motif; other site 665029009917 Walker B; other site 665029009918 D-loop; other site 665029009919 H-loop/switch region; other site 665029009920 TOBE domain; Region: TOBE_2; pfam08402 665029009921 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 665029009922 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 665029009923 dimer interface [polypeptide binding]; other site 665029009924 conserved gate region; other site 665029009925 putative PBP binding loops; other site 665029009926 ABC-ATPase subunit interface; other site 665029009927 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 665029009928 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 665029009929 dimer interface [polypeptide binding]; other site 665029009930 conserved gate region; other site 665029009931 putative PBP binding loops; other site 665029009932 ABC-ATPase subunit interface; other site 665029009933 glycerol-3-phosphate transporter periplasmic binding protein; Provisional; Region: PRK10974 665029009934 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 665029009935 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livF; PRK11614 665029009936 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 665029009937 Walker A/P-loop; other site 665029009938 ATP binding site [chemical binding]; other site 665029009939 Q-loop/lid; other site 665029009940 ABC transporter signature motif; other site 665029009941 Walker B; other site 665029009942 D-loop; other site 665029009943 H-loop/switch region; other site 665029009944 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 665029009945 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 665029009946 Walker A/P-loop; other site 665029009947 ATP binding site [chemical binding]; other site 665029009948 Q-loop/lid; other site 665029009949 ABC transporter signature motif; other site 665029009950 Walker B; other site 665029009951 D-loop; other site 665029009952 H-loop/switch region; other site 665029009953 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 665029009954 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 665029009955 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 665029009956 TM-ABC transporter signature motif; other site 665029009957 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 665029009958 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 665029009959 TM-ABC transporter signature motif; other site 665029009960 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 665029009961 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 665029009962 dimerization interface [polypeptide binding]; other site 665029009963 ligand binding site [chemical binding]; other site 665029009964 Acetyltransferase (GNAT) domain; Region: DUF3749; pfam12568 665029009965 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 665029009966 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 665029009967 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 665029009968 DNA binding residues [nucleotide binding] 665029009969 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 665029009970 putative protein insertion permease FtsX; Region: ftsX; TIGR00439 665029009971 cell division protein FtsE; Provisional; Region: PRK10908 665029009972 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 665029009973 Walker A/P-loop; other site 665029009974 ATP binding site [chemical binding]; other site 665029009975 Q-loop/lid; other site 665029009976 ABC transporter signature motif; other site 665029009977 Walker B; other site 665029009978 D-loop; other site 665029009979 H-loop/switch region; other site 665029009980 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 665029009981 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 665029009982 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 665029009983 P loop; other site 665029009984 GTP binding site [chemical binding]; other site 665029009985 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 665029009986 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 665029009987 S-adenosylmethionine binding site [chemical binding]; other site 665029009988 hypothetical protein; Provisional; Region: PRK10910 665029009989 Predicted membrane protein [Function unknown]; Region: COG3714 665029009990 zinc/cadmium/mercury/lead-transporting ATPase; Provisional; Region: zntA; PRK11033 665029009991 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 665029009992 metal-binding site [ion binding] 665029009993 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 665029009994 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 665029009995 SirA (also known as UvrY, and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A...; Region: SirA; cd03423 665029009996 CPxP motif; other site 665029009997 hypothetical protein; Provisional; Region: PRK11212 665029009998 hypothetical protein; Provisional; Region: PRK11615 665029009999 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 665029010000 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 665029010001 Metal-binding active site; metal-binding site 665029010002 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 665029010003 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 665029010004 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 665029010005 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 665029010006 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 665029010007 PYR/PP interface [polypeptide binding]; other site 665029010008 dimer interface [polypeptide binding]; other site 665029010009 TPP binding site [chemical binding]; other site 665029010010 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 665029010011 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 665029010012 TPP-binding site; other site 665029010013 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 665029010014 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 665029010015 substrate binding site [chemical binding]; other site 665029010016 ATP binding site [chemical binding]; other site 665029010017 Uncharacterized protein conserved in bacteria (DUF2090); Region: DUF2090; pfam09863 665029010018 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3892 665029010019 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 665029010020 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 665029010021 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 665029010022 putative active site [active] 665029010023 Uncharacterized enzyme involved in inositol metabolism [Carbohydrate transport and metabolism]; Region: IolB; COG3718 665029010024 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 665029010025 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 665029010026 tetrameric interface [polypeptide binding]; other site 665029010027 NAD binding site [chemical binding]; other site 665029010028 catalytic residues [active] 665029010029 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 665029010030 Domain of unknown function DUF20; Region: UPF0118; pfam01594 665029010031 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 665029010032 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 665029010033 proline/glycine betaine transporter; Provisional; Region: PRK10642 665029010034 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 665029010035 putative substrate translocation pore; other site 665029010036 Osmosensory transporter coiled coil; Region: Osmo_CC; pfam08946 665029010037 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 665029010038 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 665029010039 putative NAD(P) binding site [chemical binding]; other site 665029010040 putative substrate binding site [chemical binding]; other site 665029010041 catalytic Zn binding site [ion binding]; other site 665029010042 structural Zn binding site [ion binding]; other site 665029010043 dimer interface [polypeptide binding]; other site 665029010044 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 665029010045 DNA binding residues [nucleotide binding] 665029010046 dimerization interface [polypeptide binding]; other site 665029010047 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 665029010048 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 665029010049 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 665029010050 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154 665029010051 homotrimer interaction site [polypeptide binding]; other site 665029010052 putative active site [active] 665029010053 ornithine cyclodeaminase; Validated; Region: PRK06199 665029010054 Ornithine cyclodeaminase/mu-crystallin family; Region: OCD_Mu_crystall; pfam02423 665029010055 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 665029010056 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 665029010057 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 665029010058 Predicted flavoproteins [General function prediction only]; Region: COG2081 665029010059 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 665029010060 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 665029010061 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 665029010062 universal stress protein UspB; Provisional; Region: PRK04960 665029010063 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 665029010064 Ligand Binding Site [chemical binding]; other site 665029010065 putative methyltransferase; Provisional; Region: PRK10742 665029010066 oligopeptidase A; Provisional; Region: PRK10911 665029010067 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 665029010068 active site 665029010069 Zn binding site [ion binding]; other site 665029010070 CAAX protease self-immunity; Region: Abi; pfam02517 665029010071 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 665029010072 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 665029010073 glutathione reductase; Validated; Region: PRK06116 665029010074 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 665029010075 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 665029010076 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 665029010077 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 665029010078 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 665029010079 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 665029010080 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 665029010081 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 665029010082 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 665029010083 FMN-binding pocket [chemical binding]; other site 665029010084 flavin binding motif; other site 665029010085 phosphate binding motif [ion binding]; other site 665029010086 beta-alpha-beta structure motif; other site 665029010087 NAD binding pocket [chemical binding]; other site 665029010088 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 665029010089 catalytic loop [active] 665029010090 iron binding site [ion binding]; other site 665029010091 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 665029010092 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 665029010093 [2Fe-2S] cluster binding site [ion binding]; other site 665029010094 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 665029010095 hydrophobic ligand binding site; other site 665029010096 Transcriptional regulator [Transcription]; Region: LysR; COG0583 665029010097 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 665029010098 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 665029010099 dimerization interface [polypeptide binding]; other site 665029010100 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 665029010101 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 665029010102 hypothetical protein; Provisional; Region: PRK05208 665029010103 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 665029010104 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 665029010105 potential protein location (hypothetical protein predicted by Glimmer/Critica) that overlaps protein (hypothetical protein predicted by Glimmer/Critica) 665029010106 potential protein location (hypothetical protein predicted by Glimmer/Critica) that overlaps protein (hypothetical protein predicted by Glimmer/Critica) 665029010107 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 665029010108 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 665029010109 Transcriptional regulator [Transcription]; Region: LysR; COG0583 665029010110 The C-terminal substrate binding domain of LysR-type transcriptional regulators that are involved in the catabolism of dinitrotoluene, naphthalene and gamma-hexachlorohexane; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_NahR_LinR_like; cd08459 665029010111 dimerization interface [polypeptide binding]; other site 665029010112 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 665029010113 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 665029010114 FAD binding pocket [chemical binding]; other site 665029010115 FAD binding motif [chemical binding]; other site 665029010116 phosphate binding motif [ion binding]; other site 665029010117 NAD binding pocket [chemical binding]; other site 665029010118 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 665029010119 Protein of unknown function, DUF482; Region: DUF482; pfam04339 665029010120 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 665029010121 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 665029010122 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 665029010123 Walker A/P-loop; other site 665029010124 ATP binding site [chemical binding]; other site 665029010125 Q-loop/lid; other site 665029010126 ABC transporter signature motif; other site 665029010127 Walker B; other site 665029010128 D-loop; other site 665029010129 H-loop/switch region; other site 665029010130 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 665029010131 dimer interface [polypeptide binding]; other site 665029010132 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 665029010133 putative CheW interface [polypeptide binding]; other site 665029010134 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 665029010135 Strictosidine synthase; Region: Str_synth; pfam03088 665029010136 sensor protein KdpD; Provisional; Region: PRK10490 665029010137 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 665029010138 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 665029010139 Ligand Binding Site [chemical binding]; other site 665029010140 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 665029010141 GAF domain; Region: GAF_3; pfam13492 665029010142 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 665029010143 dimer interface [polypeptide binding]; other site 665029010144 phosphorylation site [posttranslational modification] 665029010145 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 665029010146 ATP binding site [chemical binding]; other site 665029010147 Mg2+ binding site [ion binding]; other site 665029010148 G-X-G motif; other site 665029010149 potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315 665029010150 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 665029010151 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 665029010152 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 665029010153 Inosine-uridine preferring nucleoside hydrolase; Region: IU_nuc_hydro; pfam01156 665029010154 active site 665029010155 Protein of unknown function (DUF1471); Region: DUF1471; cl11507 665029010156 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 665029010157 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 665029010158 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 665029010159 HlyD family secretion protein; Region: HlyD_3; pfam13437 665029010160 ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618 665029010161 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 665029010162 ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246 665029010163 Walker A/P-loop; other site 665029010164 ATP binding site [chemical binding]; other site 665029010165 Q-loop/lid; other site 665029010166 ABC transporter signature motif; other site 665029010167 Walker B; other site 665029010168 D-loop; other site 665029010169 Protease inhibitor Inh; Region: Inh; pfam02974 665029010170 Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases are important virulence factors in pathogenic bacteria. They may be secreted into the medium via a mechanism found in gram-negative bacteria, that does not...; Region: ZnMc_serralysin_like; cd04277 665029010171 active site 665029010172 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 665029010173 potential frameshift: common BLAST hit: gi|188535484|ref|YP_001909281.1| Oxidoreductase 665029010174 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 665029010175 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 665029010176 Domain of unknown function DUF; Region: DUF204; pfam02659 665029010177 Domain of unknown function DUF; Region: DUF204; pfam02659 665029010178 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 665029010179 M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885 665029010180 metal binding site [ion binding]; metal-binding site 665029010181 dimer interface [polypeptide binding]; other site 665029010182 Protein of unknown function (DUF1158); Region: DUF1158; pfam06643 665029010183 magnesium-transporting ATPase; Provisional; Region: PRK15122 665029010184 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 665029010185 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 665029010186 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 665029010187 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 665029010188 motif II; other site 665029010189 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 665029010190 MgtC family; Region: MgtC; pfam02308 665029010191 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 665029010192 metabolite-proton symporter; Region: 2A0106; TIGR00883 665029010193 putative substrate translocation pore; other site 665029010194 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 665029010195 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 665029010196 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 665029010197 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 665029010198 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 665029010199 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 665029010200 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 665029010201 putative diguanylate cyclase; Provisional; Region: PRK13561 665029010202 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 665029010203 metal binding site [ion binding]; metal-binding site 665029010204 active site 665029010205 I-site; other site 665029010206 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 665029010207 Protein of unknown function (DUF2819); Region: DUF2819; pfam10995 665029010208 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 665029010209 Cellulose synthase subunit D; Region: Cellsynth_D; pfam03500 665029010210 Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420 665029010211 cellulose synthase regulator protein; Provisional; Region: PRK11114 665029010212 cellulose synthase catalytic subunit (UDP-forming); Region: CelA; TIGR03030 665029010213 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 665029010214 DXD motif; other site 665029010215 PilZ domain; Region: PilZ; pfam07238 665029010216 cellulose synthase operon protein YhjQ; Region: cellulose_yhjQ; TIGR03371 665029010217 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 665029010218 P-loop; other site 665029010219 Magnesium ion binding site [ion binding]; other site 665029010220 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 665029010221 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 665029010222 Walker A/P-loop; other site 665029010223 ATP binding site [chemical binding]; other site 665029010224 Q-loop/lid; other site 665029010225 ABC transporter signature motif; other site 665029010226 Walker B; other site 665029010227 D-loop; other site 665029010228 H-loop/switch region; other site 665029010229 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 665029010230 dipeptide transporter ATP-binding subunit; Provisional; Region: dppD; PRK11022 665029010231 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 665029010232 Walker A/P-loop; other site 665029010233 ATP binding site [chemical binding]; other site 665029010234 Q-loop/lid; other site 665029010235 ABC transporter signature motif; other site 665029010236 Walker B; other site 665029010237 D-loop; other site 665029010238 H-loop/switch region; other site 665029010239 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 665029010240 dipeptide transporter; Provisional; Region: PRK10913 665029010241 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 665029010242 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 665029010243 dimer interface [polypeptide binding]; other site 665029010244 conserved gate region; other site 665029010245 putative PBP binding loops; other site 665029010246 ABC-ATPase subunit interface; other site 665029010247 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 665029010248 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 665029010249 dimer interface [polypeptide binding]; other site 665029010250 conserved gate region; other site 665029010251 putative PBP binding loops; other site 665029010252 ABC-ATPase subunit interface; other site 665029010253 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 665029010254 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 665029010255 peptide binding site [polypeptide binding]; other site 665029010256 phosphoethanolamine transferase; Provisional; Region: PRK11560 665029010257 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 665029010258 Sulfatase; Region: Sulfatase; pfam00884 665029010259 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 665029010260 Transcriptional regulators [Transcription]; Region: MarR; COG1846 665029010261 MarR family; Region: MarR; pfam01047 665029010262 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 665029010263 HD domain; Region: HD_4; pfam13328 665029010264 Predicted amidohydrolase [General function prediction only]; Region: COG0388 665029010265 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 665029010266 active site 665029010267 catalytic triad [active] 665029010268 dimer interface [polypeptide binding]; other site 665029010269 HNH endonuclease; Region: HNH_2; pfam13391 665029010270 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG3392 665029010271 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 665029010272 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 665029010273 potential protein location (hypothetical protein predicted by Glimmer/Critica) that overlaps protein (adenine-specific methyltransferase) 665029010274 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 665029010275 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 665029010276 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 665029010277 Uncharacterized conserved protein [Function unknown]; Region: COG4095 665029010278 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 665029010279 Acyltransferase family; Region: Acyl_transf_3; pfam01757 665029010280 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 665029010281 dimer interface [polypeptide binding]; other site 665029010282 motif 1; other site 665029010283 active site 665029010284 motif 2; other site 665029010285 motif 3; other site 665029010286 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 665029010287 DALR anticodon binding domain; Region: DALR_1; pfam05746 665029010288 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 665029010289 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 665029010290 putative NAD(P) binding site [chemical binding]; other site 665029010291 putative substrate binding site [chemical binding]; other site 665029010292 catalytic Zn binding site [ion binding]; other site 665029010293 structural Zn binding site [ion binding]; other site 665029010294 dimer interface [polypeptide binding]; other site 665029010295 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 665029010296 non-specific DNA binding site [nucleotide binding]; other site 665029010297 salt bridge; other site 665029010298 sequence-specific DNA binding site [nucleotide binding]; other site 665029010299 Protein of unknown function (DUF3053); Region: DUF3053; pfam11254 665029010300 PTS system mannitol-specific transporter subunit IICBA; Provisional; Region: PRK15083 665029010301 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 665029010302 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 665029010303 active site 665029010304 P-loop; other site 665029010305 phosphorylation site [posttranslational modification] 665029010306 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 665029010307 active site 665029010308 phosphorylation site [posttranslational modification] 665029010309 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 665029010310 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 665029010311 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 665029010312 Transcriptional regulator [Transcription]; Region: MtlR; COG3722 665029010313 mannitol repressor protein; Provisional; Region: mtlR; PRK11001 665029010314 hypothetical protein; Provisional; Region: PRK11020 665029010315 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 665029010316 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 665029010317 DNA binding residues [nucleotide binding] 665029010318 dimerization interface [polypeptide binding]; other site 665029010319 FaeA-like protein; Region: FaeA; pfam04703 665029010320 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 665029010321 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 665029010322 DNA binding site [nucleotide binding] 665029010323 Methylthioribose-binding protein-like of ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_methylthioribose_binding_like; cd06305 665029010324 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 665029010325 putative ligand binding site [chemical binding]; other site 665029010326 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 665029010327 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 665029010328 TM-ABC transporter signature motif; other site 665029010329 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 665029010330 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 665029010331 Walker A/P-loop; other site 665029010332 ATP binding site [chemical binding]; other site 665029010333 Q-loop/lid; other site 665029010334 ABC transporter signature motif; other site 665029010335 Walker B; other site 665029010336 D-loop; other site 665029010337 H-loop/switch region; other site 665029010338 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 665029010339 superoxide dismutase; Provisional; Region: PRK10925 665029010340 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 665029010341 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 665029010342 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 665029010343 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 665029010344 inhibitor-cofactor binding pocket; inhibition site 665029010345 pyridoxal 5'-phosphate binding site [chemical binding]; other site 665029010346 catalytic residue [active] 665029010347 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 665029010348 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 665029010349 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 665029010350 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 665029010351 formate dehydrogenase accessory protein FdhE; Provisional; Region: PRK03564 665029010352 formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562 665029010353 putative glutathione S-transferase; Provisional; Region: PRK10357 665029010354 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 665029010355 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 665029010356 dimer interface [polypeptide binding]; other site 665029010357 N-terminal domain interface [polypeptide binding]; other site 665029010358 putative substrate binding pocket (H-site) [chemical binding]; other site 665029010359 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 665029010360 putative outer membrane lipoprotein; Provisional; Region: PRK10510 665029010361 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 665029010362 ligand binding site [chemical binding]; other site 665029010363 Transcriptional regulators [Transcription]; Region: PurR; COG1609 665029010364 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 665029010365 DNA binding site [nucleotide binding] 665029010366 domain linker motif; other site 665029010367 Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283 665029010368 putative dimerization interface [polypeptide binding]; other site 665029010369 putative ligand binding site [chemical binding]; other site 665029010370 Protein-tyrosine phosphatase; Region: Y_phosphatase; pfam00102 665029010371 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cd00047 665029010372 active site 665029010373 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 665029010374 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 665029010375 substrate binding site [chemical binding]; other site 665029010376 ATP binding site [chemical binding]; other site 665029010377 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 665029010378 D-galactonate transporter; Region: 2A0114; TIGR00893 665029010379 putative substrate translocation pore; other site 665029010380 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 665029010381 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 665029010382 dimerization interface [polypeptide binding]; other site 665029010383 ligand binding site [chemical binding]; other site 665029010384 NADP binding site [chemical binding]; other site 665029010385 catalytic site [active] 665029010386 Aldose 1-epimerase, similar to Escherichia coli c4013; Region: Aldose_epim_Ec_c4013; cd09023 665029010387 active site 665029010388 catalytic residues [active] 665029010389 valine--pyruvate transaminase; Provisional; Region: avtA; PRK09440 665029010390 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 665029010391 pyridoxal 5'-phosphate binding site [chemical binding]; other site 665029010392 homodimer interface [polypeptide binding]; other site 665029010393 catalytic residue [active] 665029010394 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 665029010395 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 665029010396 putative dimer interface [polypeptide binding]; other site 665029010397 Protein of unknown function (DUF1375); Region: DUF1375; cl11456 665029010398 Protein of unknown function (DUF3748); Region: DUF3748; pfam12566 665029010399 sugar phosphate phosphatase; Provisional; Region: PRK10513 665029010400 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 665029010401 active site 665029010402 motif I; other site 665029010403 motif II; other site 665029010404 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 665029010405 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 665029010406 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 665029010407 ATP binding site [chemical binding]; other site 665029010408 Mg2+ binding site [ion binding]; other site 665029010409 G-X-G motif; other site 665029010410 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 665029010411 anchoring element; other site 665029010412 dimer interface [polypeptide binding]; other site 665029010413 ATP binding site [chemical binding]; other site 665029010414 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 665029010415 active site 665029010416 putative metal-binding site [ion binding]; other site 665029010417 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 665029010418 recF protein; Region: recf; TIGR00611 665029010419 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 665029010420 Walker A/P-loop; other site 665029010421 ATP binding site [chemical binding]; other site 665029010422 Q-loop/lid; other site 665029010423 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 665029010424 ABC transporter signature motif; other site 665029010425 Walker B; other site 665029010426 D-loop; other site 665029010427 H-loop/switch region; other site 665029010428 DNA polymerase III subunit beta; Validated; Region: PRK05643 665029010429 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 665029010430 putative DNA binding surface [nucleotide binding]; other site 665029010431 dimer interface [polypeptide binding]; other site 665029010432 beta-clamp/clamp loader binding surface; other site 665029010433 beta-clamp/translesion DNA polymerase binding surface; other site 665029010434 DnaA N-terminal domain; Region: DnaA_N; pfam11638 665029010435 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 665029010436 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 665029010437 Walker A motif; other site 665029010438 ATP binding site [chemical binding]; other site 665029010439 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 665029010440 Walker B motif; other site 665029010441 arginine finger; other site 665029010442 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 665029010443 DnaA box-binding interface [nucleotide binding]; other site 665029010444 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 665029010445 ribonuclease P; Reviewed; Region: rnpA; PRK01732 665029010446 hypothetical protein; Validated; Region: PRK00041 665029010447 membrane protein insertase; Provisional; Region: PRK01318 665029010448 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 665029010449 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 665029010450 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 665029010451 trmE is a tRNA modification GTPase; Region: trmE; cd04164 665029010452 G1 box; other site 665029010453 GTP/Mg2+ binding site [chemical binding]; other site 665029010454 Switch I region; other site 665029010455 G2 box; other site 665029010456 Switch II region; other site 665029010457 G3 box; other site 665029010458 G4 box; other site 665029010459 G5 box; other site 665029010460 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 665029010461 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 665029010462 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 665029010463 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 665029010464 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 665029010465 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 665029010466 non-specific DNA interactions [nucleotide binding]; other site 665029010467 DNA binding site [nucleotide binding] 665029010468 sequence specific DNA binding site [nucleotide binding]; other site 665029010469 putative cAMP binding site [chemical binding]; other site 665029010470 benzoate transport; Region: 2A0115; TIGR00895 665029010471 transcriptional regulator PhoU; Provisional; Region: PRK11115 665029010472 PhoU domain; Region: PhoU; pfam01895 665029010473 PhoU domain; Region: PhoU; pfam01895 665029010474 phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744 665029010475 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 665029010476 Walker A/P-loop; other site 665029010477 ATP binding site [chemical binding]; other site 665029010478 Q-loop/lid; other site 665029010479 ABC transporter signature motif; other site 665029010480 Walker B; other site 665029010481 D-loop; other site 665029010482 H-loop/switch region; other site 665029010483 phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268 665029010484 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 665029010485 dimer interface [polypeptide binding]; other site 665029010486 conserved gate region; other site 665029010487 putative PBP binding loops; other site 665029010488 ABC-ATPase subunit interface; other site 665029010489 phosphate transporter permease subunit PstC; Provisional; Region: pstC; PRK11275 665029010490 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 665029010491 dimer interface [polypeptide binding]; other site 665029010492 conserved gate region; other site 665029010493 putative PBP binding loops; other site 665029010494 ABC-ATPase subunit interface; other site 665029010495 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 665029010496 substrate binding pocket [chemical binding]; other site 665029010497 membrane-bound complex binding site; other site 665029010498 hinge residues; other site 665029010499 Glycosyl hydrolase family 68, includes levansucrase, beta-fructofuranosidase and inulosucrase; Region: GH68; cd08997 665029010500 active site 665029010501 Phage holin family (Lysis protein S); Region: Phage_holin_3; pfam05106 665029010502 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 665029010503 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 665029010504 glutaminase active site [active] 665029010505 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 665029010506 dimer interface [polypeptide binding]; other site 665029010507 active site 665029010508 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 665029010509 dimer interface [polypeptide binding]; other site 665029010510 active site 665029010511 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK09451 665029010512 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 665029010513 Substrate binding site; other site 665029010514 Mg++ binding site; other site 665029010515 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 665029010516 active site 665029010517 substrate binding site [chemical binding]; other site 665029010518 CoA binding site [chemical binding]; other site 665029010519 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 665029010520 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 665029010521 gamma subunit interface [polypeptide binding]; other site 665029010522 epsilon subunit interface [polypeptide binding]; other site 665029010523 LBP interface [polypeptide binding]; other site 665029010524 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 665029010525 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 665029010526 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 665029010527 alpha subunit interaction interface [polypeptide binding]; other site 665029010528 Walker A motif; other site 665029010529 ATP binding site [chemical binding]; other site 665029010530 Walker B motif; other site 665029010531 inhibitor binding site; inhibition site 665029010532 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 665029010533 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 665029010534 core domain interface [polypeptide binding]; other site 665029010535 delta subunit interface [polypeptide binding]; other site 665029010536 epsilon subunit interface [polypeptide binding]; other site 665029010537 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 665029010538 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 665029010539 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 665029010540 beta subunit interaction interface [polypeptide binding]; other site 665029010541 Walker A motif; other site 665029010542 ATP binding site [chemical binding]; other site 665029010543 Walker B motif; other site 665029010544 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 665029010545 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 665029010546 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 665029010547 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 665029010548 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 665029010549 ATP synthase, F0 subunit c; Region: ATP_synt_c; TIGR01260 665029010550 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 665029010551 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 665029010552 F0F1 ATP synthase subunit I; Validated; Region: PRK08049 665029010553 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 665029010554 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 665029010555 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 665029010556 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 665029010557 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932